CN112219118B - Blood sampling container - Google Patents

Abstract

The present invention provides a blood collection container that can prevent cracks or cracks on the bottom surface even when the blood collection container is exposed to a low temperature environment after blood collection. The blood collection container of the present invention includes a blood collection container main body and a plug body. The blood collection container main body has an open end, a side part and a bottom part. The plug body is inserted into the open end. The thickness of the bottom end of the bottom part is equal to the thickness of the bottom part. The ratio of the average thickness of the side portion is 1.25 or more and 1.75 or less, and the material of the blood collection container body contains polyethylene terephthalate with an intrinsic viscosity of 0.75 dL/g or more and 0.79 dL/g or less.

Description

blood collection container

Technical field

The present invention relates to blood collection containers.

Background technique

In clinical examinations, blood collection containers such as blood collection tubes are widely used to collect blood. Furthermore, serum or plasma can be separated from collected blood (whole blood) by using a blood collection container containing a serum or plasma separation composition inside.

As an example of a blood collection container, the following Patent Document 1 discloses a blood collection container including a tube main body having an open first end, a sheet, and a hemostatic valve. The first end engages and blocks the opening, and the hemostatic valve can open in the length direction of the tube body through elastic deformation. The hemostatic valve is arranged in the tube body so as to separate the first end side and the opposite side with respect to the longitudinal direction of the tube body.

existing technical documents

patent documents

Patent Document 1: Japanese Patent Application Publication No. 2010-154909

Contents of the invention

The technical problem solved by the invention

The blood collection container after blood collection may be in a low-temperature environment (for example, -20°C or lower) by placing dry ice or the like on the upper part of the blood collection container after performing centrifugal separation to separate serum or plasma from blood. ) for storage or transportation. In this case, the blood-derived sample such as serum or plasma located above the blood collection container is frozen due to the influence of dry ice or the like.

Since blood-derived samples such as serum and plasma contain a large amount of water, when the blood-derived samples are frozen, the volume increases compared to before freezing. Therefore, when a blood collection container or the like is stored by the above method, the blood-derived sample located above the blood collection container is first frozen, thereby suppressing the freezing expansion of the blood-derived sample located below the blood collection container, and a force is applied to the bottom surface of the blood collection container department.

In the conventional blood collection container described in Patent Document 1, the strength of the bottom portion of the blood collection container body is low, and when frozen by the above method, the sample derived from blood may expand due to freezing. This causes cracks or cracks to occur on the bottom surface.

An object of the present invention is to provide a blood collection container that can prevent cracks or cracks on the bottom surface even when the blood collection container is exposed to a low temperature environment after blood collection.

Technical means to solve problems

According to a broad aspect of the present invention, a blood collection container is provided, which is provided with a blood collection container main body and a plug body. The blood collection container main body has an open end, a side part, and a bottom part. The plug body is inserted into the open end, and the bottom part is The ratio of the thickness of the bottom end to the average thickness of the side portion is 1.25 or more and 1.75 or less, and the material of the blood collection container body contains polyethylene terephthalate with an intrinsic viscosity of 0.75 dL/g or more and 0.79 dL/g or less.

In a specific aspect of the blood collection container of the present invention, the thickness of the bottom end of the bottom portion is 1.25 mm or more and 1.75 mm or less.

In another specific aspect of the blood collection container of the present invention, the blood collection container is provided with a serum or plasma separation composition, and the serum or plasma separation composition is accommodated in the blood collection container main body.

In another specific aspect of the blood collection container of the present invention, the blood collection container is provided with a blood clot stripping agent, and the blood clot stripping agent is attached to the inner wall surface of the blood collection container main body.

Invention effect

The blood collection container of the present invention includes a blood collection container main body having an open end, a side surface and a bottom surface, and a plug body inserted into the open end. In the blood collection container of the present invention, the ratio of the thickness of the bottom end of the bottom portion to the average thickness of the side portion is 1.25 or more and 1.75 or less. In the case of the blood collection container of the present invention, the material of the blood collection container body contains polyethylene terephthalate with an intrinsic viscosity of 0.75 dL/g or more and 0.79 dL/g or less. In the case of the blood collection container of the present invention, since it has the above-mentioned structure, even when the blood collection container is exposed to a low-temperature environment after blood collection, it is possible to prevent cracks or cracks on the bottom surface.

Description of the drawings

FIG. 1 is a front cross-sectional view of the main body of the blood collection container according to one embodiment of the present invention.

2(a) and (b) are a front view and a front cross-sectional view of the plug body according to one embodiment of the present invention.

3 is a front cross-sectional view of the blood collection container according to one embodiment of the present invention.

Detailed ways

Hereinafter, the present invention will be described in detail.

The blood collection container of the present invention includes a blood collection container main body having an open end, a side surface and a bottom surface, and a plug body inserted into the open end. In the blood collection container of the present invention, the ratio of the thickness of the bottom end of the bottom portion to the average thickness of the side portion is 1.25 or more and 1.75 or less. In the case of the blood collection container of the present invention, the material of the blood collection container body contains polyethylene terephthalate with an intrinsic viscosity of 0.75 dL/g or more and 0.79 dL/g or less.

In the case of the blood collection container of the present invention, since it has the above-mentioned structure, even when the blood collection container is exposed to a low-temperature environment after blood collection, it is possible to prevent cracks or cracks on the bottom surface.

In addition, in the case of the blood collection container of the present invention, it is possible to prevent cracks or cracks in the side portion.

Generally, the bottom portion of the blood collection container body has a circular shape. For example, the shape of the bottom portion of the blood collection container is a circular arc shape or an elliptical arc shape when the blood collection container body is viewed from the front. In the case of conventional blood collection containers, in order to improve the formability of the blood collection container body, a resin with a low intrinsic viscosity (for example, polyethylene terephthalate with an intrinsic viscosity of about 0.6 dL/g) is used as the blood collection container. The material of the subject. In addition, in the case of the conventional blood collection container, the thickness of the side portion of the blood collection container body is substantially the same as the thickness of the bottom portion. Therefore, in the case of conventional blood collection containers, the strength of the bottom portion of the blood collection container body is low, and cracks or cracks may occur in the bottom portion due to freezing expansion of the blood-derived sample.

In contrast, in the case of the blood collection container of the present invention, a material containing polyethylene terephthalate having a specific intrinsic viscosity is used as the material of the blood collection container body, and the blood collection container body has a specific shape. , therefore, the strength of the bottom portion can be improved. Therefore, even when dry ice or the like is placed on the upper part of a blood collection container that has been centrifuged to separate serum or plasma from blood and the blood collection container is exposed to a low temperature environment (for example, -20° C. or lower), it is possible to prevent the bottom surface from being Internal cracks or cracks.

In the present invention, in order to improve the strength of the bottom portion of the blood collection container body, the thickness of the blood collection container body (thickness of the side portion and the thickness of the bottom portion) is not increased as a whole, but the ratio of the thickness of the bottom portion to the thickness of the side portion is relatively increased. Therefore, it can be used in a transport device of a commonly used automatic analyzer, and the manufacturing cost can be reduced compared to a blood collection container in which the thickness of the entire blood collection container body is increased.

Hereinafter, specific embodiments of the present invention will be described with reference to the drawings.

FIG. 1 is a front cross-sectional view of the main body of the blood collection container according to one embodiment of the present invention.

The blood collection container main body 1 has an open end 1a, a side surface 1b, and a bottom surface 1c. One end of the blood collection container body 1 is open, and the other end opposite to this end is closed. The side part 1b is connected to the bottom part 1c. The blood collection container main body 1 has an open end 1a at one end and a bottom end 11c with a bottom surface 1c at the other end.

The bottom portion 1c has a circular shape. The outer shape of the bottom portion 1 c is in the shape of a circular arc or an elliptical arc when the blood collection container body 1 is viewed from the front. The outer shape of the side portion 1 b is not in the shape of a circular arc or an elliptical arc when the blood collection container body 1 is viewed from the front. By observing the outer shape of the bottom portion and the outer shape of the side portion, the bottom portion and the side portion can be distinguished.

The ratio of the thickness of the bottom end 11c of the bottom portion 1c of the blood collection container body 1 to the average thickness of the side portion 1b (thickness of the bottom end 11c of the bottom portion 1c/average thickness of the side portion 1b) is 1.25 or more and 1.75 or less. When the ratio (thickness of the bottom end 11c of the bottom portion 1c/average thickness of the side portion 1b) is less than 1.25, the strength of the bottom portion may be poor, and when the blood collection container is exposed to a low temperature environment after blood collection, it may cause Cracks or cracks on the underside. When the ratio (thickness of bottom end 11c of bottom portion 1c/average thickness of side portion 1b) is greater than 1.75, dents may be generated during molding.

The ratio of the thickness of the bottom end 11c of the bottom portion 1c to the average thickness of the side portion 1b (thickness of the bottom end 11c of the bottom portion 1c/average thickness of the side portion 1b) is preferably 1.3 or more, and preferably 1.6 or less. When the ratio (thickness of the bottom end 11c of the bottom portion 1c/average thickness of the side portion 1b) is more than the lower limit, the strength of the bottom portion can be further improved even when the blood collection container after blood collection is exposed to a low temperature environment. It can also further effectively prevent cracks or cracks on the bottom surface. When the ratio (thickness of the bottom end 11c of the bottom portion 1c/average thickness of the side portion 1b) is equal to or less than the upper limit, molding defects can be reduced.

The average thickness of the side portion is determined by determining the thickness of the side portion at five or more locations selected at 10 mm intervals from the opening end of the blood collection container body 10 mm lower than the bottom portion, and then the thickness at each location is calculated. Obtained by averaging.

The average thickness of the side part 1b is preferably 0.8 mm or more, more preferably 0.9 mm or more, preferably 1.5 mm or less, more preferably 1.3 mm or less. When the average thickness of the side portion 1 b is not less than the lower limit and not more than the upper limit, the strength of the blood collection container body can be further improved.

The thickness of the bottom end 11c of the bottom portion 1c is preferably 1.25 mm or more, more preferably 1.3 mm or more, preferably 1.75 mm or less, and more preferably 1.6 mm or less. When the thickness of the bottom end 11c of the bottom portion 1c is more than the lower limit and less than the upper limit, the strength of the bottom portion can be further improved, and even when the blood collection container after blood collection is exposed to a low temperature environment, it can be more effectively Prevent cracks or cracks on the bottom surface.

The side portion 1b may or may not be inclined inward from the opening end side to the bottom portion side.

The material of the blood collection container main body 1 includes polyethylene terephthalate with an intrinsic viscosity of not less than 0.75 dL/g and not more than 0.79 dL/g. When the intrinsic viscosity is less than 0.75 dL/g or greater than 0.79 dL/g, the blood collection container body has poor formability and may not be able to be formed into a bottom portion with a specific shape. It should be noted that only one type of material may be used for the blood collection container main body 1, or two or more types may be used in combination.

The intrinsic viscosity of the polyethylene terephthalate is preferably 0.76 dL/g or more, and more preferably 0.78 dL/g or less. When the intrinsic viscosity of the polyethylene terephthalate is not less than the lower limit and not more than the upper limit, the formability can be further improved, and the bottom portion can be formed more favorably.

The intrinsic viscosity is determined based on JIS K7390:2003.

The material of the blood collection container main body 1 may include, for example, polyester other than polyethylene terephthalate having the intrinsic viscosity of 0.75 dL/g or more and 0.79 dL/g or less.

In 100% by weight of the material of the main body of the blood collection container, the content of polyethylene terephthalate with an intrinsic viscosity of 0.75 dL/g or more and 0.79 dL/g or less is preferably 85% by weight or more, and more preferably 90% by weight. % or more, more preferably 95 wt% or more, particularly preferably 99 wt% or more, most preferably 100 wt% (total). Therefore, the material of the main body of the blood collection container is most preferably polyethylene terephthalate having an intrinsic viscosity of 0.75 dL/g or more and 0.79 dL/g or less.

Fig. 2(a) is a front view of the plug body according to one embodiment of the present invention. Fig. 2(b) is a front cross-sectional view of the plug body according to one embodiment of the present invention.

The plug body 2 includes a cover member 21 and a plug main body 22 . The cover member 21 is externally installed so as to cover the outer surface of the plug main body 22 . The outer surface of the plug body 22 is in contact with the inner surface of the cover member 21 .

The cover member 21 has a plurality of protruding ribs 21a on the outer side in the diameter direction of the cover member. The cover member may or may not have ribs. It is preferable that the cover member has ribs from the viewpoint of improving the operability of the cover member, the stopper body, and the blood collection container, such as making it easy to remove the embolus body from the blood collection container body after blood collection or preventing the cover member, the embolus body, and the blood collection container from rolling.

The plug main body 22 has a large diameter part on the upper end side and a small diameter part on the lower end side. The plug main body 22 forms a step by a large diameter part and a small diameter part.

Preferably, the material of the plug body 22 is elastomer. Only one type of material may be used for the plug main body 22, or two or more types may be used in combination.

Examples of the elastomer include thermosetting elastomers, thermoplastic elastomers, and the like. Examples of the thermosetting elastomer include isoprene rubber, butyl rubber, butadiene rubber, styrene-butadiene copolymer rubber, and the like. Examples of the thermoplastic elastomer include styrenic elastomers.

When the material of the plug body 22 is the elastomer, the plug body 22 is a rubber plug. Preferably, the plug body 22 is a rubber plug. When the plug body is a rubber plug, since the plug body can be deformed well, the plug body can be effectively suppressed from falling off the cover member.

From the viewpoint that the cap member can be used regardless of the size of the blood collection container, the maximum inner diameter of the cap member 21 is preferably 12 mm or more, more preferably 13 mm or more, preferably 18 mm or less, and more preferably 17 mm or less.

From the viewpoint of improving the operability of the cover member, the length of the cover member 21 is preferably 11 mm or more, more preferably 15 mm or more, preferably 25 mm or less, and more preferably 20 mm or less.

3 is a front cross-sectional view of the blood collection container according to one embodiment of the present invention.

The blood collection container 4 includes the blood collection container main body 1 shown in FIG. 1 , the embolus 2 shown in FIG. 2 , and the serum or plasma separation composition 3 . The plug body 2 is inserted into the open end 1a of the blood collection container body 1. The small diameter portion of the stopper main body 22 is inserted into the blood collection container main body 1 . The step portion of the plug body 22 is connected to the upper end of the blood collection container body 1 . The serum or plasma separation composition 3 is accommodated in the blood collection container main body 1 .

The blood collection container of the present invention preferably includes a serum or plasma separation composition.

The composition for separating serum or plasma is used to separate serum or plasma from blood.

When serum is separated from blood, blood is collected into a blood collection container containing serum or a plasma separation composition, and then centrifugally separated using a centrifugal separation device. By centrifugation, cellular components and blood coagulation components in the blood are precipitated below (blood clot), and the serum is separated into the supernatant. At this time, the serum or plasma separation composition is located in the middle layer, forming a partition wall that isolates the blood clot and serum.

As the serum or plasma separation composition, conventionally known serum or plasma separation compositions can be used. Examples of the serum or plasma separation composition include the serum or plasma separation composition described in WO2011/105151A1 and the like.

The blood collection container of the present invention preferably includes a blood clot removing agent. When the blood collection container 4 is equipped with a blood clot release agent, it is preferable that the blood clot release agent adheres to the inner wall surface of the blood collection container body 1 . By equipping the blood collection container 4 with the blood clot release agent, it is possible to prevent the blood clot from adhering to the inner wall surface of the blood collection container body 1 after blood coagulation, and to effectively separate the blood clot and serum.

As the blood clot-releasing agent, conventionally known blood clot-releasing agents can be used. Examples of the blood clot releasing agent include those described in Japanese Patent Application Publication No. 2008-304207 and Japanese Patent Application Publication No. 5-10095, etc.

Other details of the blood collection container will be described below.

The internal pressure of the blood collection container is not particularly limited. The blood collection container may be a vacuum blood collection container (vacuum blood collection tube) that is sealed by the plug body after the interior is exhausted. When the blood collection container is a vacuum blood collection tube, a certain amount of blood can be easily collected regardless of the skill difference of the blood collector.

From the viewpoint of preventing bacterial infection, it is preferable that the inside of the blood collection container is sterilized in accordance with standards described in ISO and JIS.

The blood collection container may be equipped with a blood coagulant, or may be further equipped with blood accelerators such as silica and thrombin, and anticoagulants such as heparin, ethylenediaminetetraacetic acid (EDTA), and citric acid for purposes such as anti-blood coagulation. and other well-known pharmaceuticals. For example, the medicament can be attached to the inner wall of the main body of the blood collection container.

The blood collection container main body can be prepared by injecting the material of the blood collection container main body into a metal mold corresponding to the shape of the blood collection container main body, and shaping the material. If necessary, a blood clot stripping agent can be adhered to the inner wall surface of the obtained blood collection container body, the serum or plasma separation composition is accommodated in the obtained blood collection container body, and the plug is inserted into the opening of the blood collection container body. Put it in the middle and prepare the blood collection container.

When blood is collected into the blood collection container, the blood collection container and the blood collection rack equipped with the blood collection needle are prepared, and the following steps 1) to 3) are performed. Step 1) Insert the tip of one end of the blood collection needle into the blood vessel. Step 2) Insert the blood collection container into the blood collection rack such that the tip of the other end of the blood collection needle penetrates the plug body of the blood collection container. Step 3) Since the inside of the blood collection container is depressurized, blood is sucked into the blood collection container through the blood collection needle.

Hereinafter, an Example is given and this invention is demonstrated in more detail. The present invention is not limited to the following examples.

Prepare the following plug body.

A plug body having the shape shown in Figure 2

Plug body: rubber plug (material: butyl rubber)

Cover part: length 20mm, maximum inner diameter 14mm, material: polyethylene

A composition for serum or plasma separation is prepared in the following manner.

Cyclopentadiene oligomer (manufactured by EXXON MOBIL, trade name: ESCOREZ5690) and trimellitate (manufactured by Dainippon Ink Chemical Industries, Ltd., trade name: MONOCIZER W700) were dissolved at 130°C to prepare a liquid Resin composition. Polypropylene glycol (manufactured by NOF, trade name: UNIOL D700) as polyalkylene glycol was dissolved in the liquid resin component and cooled to about 30°C. Next, as inorganic powders, hydrophilic silica fine powder (manufactured by NIPPON AEROSIL Co., Ltd., trade name: AEROSIL 200CF) and hydrophobic silica fine powder (manufactured by NIPPON AEROSIL Co., Ltd., trade name: AEROSIL R974) were added to the liquid resin. Ingredients are stirred with a planetary mixer and dispersed at the same time. Thus, a composition for serum or plasma separation is prepared. In addition, the mixing ratio of each component was 52.3 weight% of cyclopentadiene oligomer and 44.2 weight% of trimellitic acid ester based on 100 weight% of the obtained serum or plasma separation composition. %, polypropylene glycol 0.8% by weight, hydrophilic silica powder 1.0% by weight, and hydrophobic silica powder 1.7% by weight. The obtained serum or plasma separation composition had a specific gravity of 1.05 at 25°C. It should be noted that the specific gravity is measured by the flotation method.

A blood clot peeling agent containing silica (coagulant) was prepared in the following manner.

To methanol, add methanol-modified silicone oil obtained by introducing hydroxyl groups into polydimethylsiloxane, polyvinylpyrrolidone and silica fine powder (average particle size 40 μm, linseed oil absorption capacity 30ml/100g, BET specific surface area 12000cm ² /g, resistivity 26Ω·cm). Thus, a silica-containing blood clot release agent was prepared. In addition, the mixing ratio of each component was 0.1 wt% of methanol-modified silicone oil, 0.1 wt% of polyvinylpyrrolidone, and 0.1 wt% of polyvinyl pyrrolidone, based on 100 wt% of the obtained silica-containing blood clot release agent. Silica fine powder 1.0% by weight.

(Example 1)

Preparation of the main body of the blood collection container:

As a material for the main body of the blood collection container, polyethylene terephthalate with an intrinsic viscosity of 0.77 dL/g was prepared. The polyethylene terephthalate was injected into a metal mold and molded at a heating temperature of 300° C. to prepare a blood collection container main body having the shape shown in Figure 1 . The dimensions of the resulting blood collection container body are as follows. In addition, the intrinsic viscosity of polyethylene terephthalate was determined based on JIS K7390:2003. In addition, the average thickness of the side portion was determined by determining the thickness of the side portion of the blood collection container body at five or more locations selected at intervals of 10 mm from the opening end to the bottom portion 10 mm, and then the thickness at each location was calculated. Obtained by averaging. In addition, in the obtained blood collection container main body, the thickness of the portion other than the bottom end of the bottom portion is also greater than the average thickness of the side portion.

Average thickness of side parts: 1.0mm, length of side parts: 93mm

The thickness of the bottom of the bottom part: 1.25mm, the length of the bottom part: 7mm

Inner diameter of open end: 11mm

Length of main body of blood collection container: 100mm

Preparation of blood collection containers:

The obtained blood clot stripping agent containing silica is sprayed on the inner wall surface of the blood collection container body and air-dried. Next, 0.9 g of the obtained serum or plasma separation composition was placed in the main body of the blood collection container, the pressure inside the blood collection container was reduced to 12 kPa, and the blood collection container was sealed with a plug to prepare a blood collection container. In addition, 10 blood collection containers were prepared.

(Example 2)

A blood collection container body and a blood collection container were prepared in the same manner as in Example 1 except that the size of the metal mold was changed and the thickness of the bottom end of the bottom portion of the blood collection container body was 1.5 mm.

(Example 3)

A blood collection container body and a blood collection container were prepared in the same manner as in Example 1 except that the size of the metal mold was changed and the thickness of the bottom end of the bottom portion of the blood collection container body was set to 1.75 mm.

(Comparative example 1)

Polyethylene terephthalate with an intrinsic viscosity of 0.61 dL/g was used as the material of the blood collection container body, and the size of the metal mold was changed so that the thickness of the bottom end of the bottom portion of the blood collection container body was 1.0 mm. In addition, In the same manner as in Example 1, a blood collection container main body and a blood collection container were prepared. In addition, in the obtained blood collection container main body, the thickness of the part other than the bottom end of the bottom part was the same as the average thickness of the side part.

(evaluate)

<Cracks or cracks on the bottom surface in low temperature environments>

After injecting 0.9 g of salt water adjusted to a specific gravity of 1.080 at 25° C. into the obtained blood collection container, centrifugation was performed at 1700 G for 5 minutes. The serum or plasma separation composition and saline are separated by performing a centrifugation operation so that the serum or plasma separation composition (specific gravity at 25°C: 1.05) is located above and the saline is located below. Next, 2.5 mL of water for injection with a specific gravity of 1.000 at 25°C was injected. Thus, a blood collection container is prepared in which saline solution, a composition for separating serum or plasma, and water for injection are arranged in this order from the bottom surface side toward the open end side of the blood collection container.

Next, the blood collection container is placed on a test tube rack with the bottom of the blood collection container body downward, dry ice is placed on the upper end (stopper) of the blood collection container, and the container is stored in an expanded polystyrene box. Let it stand for 24 hours while keeping the temperature in the expanded polystyrene box below -40°C.

After standing, place the blood collection container at room temperature to thaw. Then, observe the bottom surface of the blood collection container body with the naked eye. Find the number of cracks or cracks on the bottom surface of 10 blood collection containers.

The structure and results of the blood collection container are shown in Table 1 below.

Symbol Description

1…blood collection container body

1a…open end

1b…Side face

1c…bottom surface

2…bolt body

3...Compositions for separation of serum or plasma

4…blood collection container

11c…bottom

21…Cover parts

21a…rib

22…bolt body

Claims (9)

1. A blood collection container, which is provided with a blood collection container main body and a plug body, the blood collection container main body has an open end, a side part and a bottom part, and the plug body is inserted into the open end, wherein, The ratio of the thickness of the bottom end of the bottom portion to the average thickness of the side portion is 1.25 or more and 1.75 or less, The material of the main body of the blood collection container includes polyethylene terephthalate with an intrinsic viscosity of 0.75dL/g or more and 0.79dL/g or less, In 100% by weight of the material of the main body of the blood collection container, the content of polyethylene terephthalate with an intrinsic viscosity of 0.75 dL/g or more and 0.79 dL/g or less is 95% by weight or more. 2. The blood collection container according to claim 1, wherein, The thickness of the bottom end of the bottom portion is 1.25 mm or more and 1.75 mm or less. 3. The blood collection container according to claim 1 or 2, wherein, The average thickness of the side portion is 0.8 mm or more and 1.5 mm or less. 4. The blood collection container according to claim 1 or 2, wherein, The plug body includes a cover member and a plug main body. 5. The blood collection container according to claim 4, wherein, The maximum inner diameter of the cover member is 12 mm or more and 18 mm or less. 6. The blood collection container according to claim 4, wherein, The length of the cover member is not less than 11 mm and not more than 25 mm. 7. The blood collection container according to claim 4, wherein, The material of the plug body is thermosetting elastomer or thermoplastic elastomer, The thermosetting elastomer is isoprene rubber, butyl rubber, butadiene rubber, or styrene-butadiene co-overlapping rubber, The thermoplastic elastomer is a styrenic elastomer. 8. The blood collection container according to claim 1 or 2, which is provided with a serum or plasma separation composition, wherein: The serum or plasma separation composition is contained in the main body of the blood collection container. 9. The blood collection container according to any one of claims 1 or 2, which is provided with a blood clot stripping agent, wherein: The blood clot stripping agent is attached to the inner wall surface of the main body of the blood collection container.