CN112198326A - Liquid detection adapter - Google Patents
Liquid detection adapter Download PDFInfo
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- CN112198326A CN112198326A CN201910612164.2A CN201910612164A CN112198326A CN 112198326 A CN112198326 A CN 112198326A CN 201910612164 A CN201910612164 A CN 201910612164A CN 112198326 A CN112198326 A CN 112198326A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
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- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
本发明提供一种液体检测转接装置，至少包括：储液装置连接板，所述储液装置连接板上设有储液装置液流接口，所述储液装置液流接口与所述储液装置连接的一侧设有密封圈；检测装置连接板，所述检测装置连接板上设有检测装置液流接口和检测装置排液接口，所述检测装置液流接口和检测装置排液接口的与所述检测装置连接的一侧分别设有密封圈；输液流道，用于连通储液装置液流接口和检测装置液流接口。本发明所述的液体检测转接装置，可以使储液装置不直接与检测装置相连，实现快速的接驳与插拔，同时规整流道，大大降低了对管道的用量，提高了设备整体的稳定性。The present invention provides a liquid detection switching device, comprising at least: a liquid storage device connecting plate, the liquid storage device connecting plate is provided with a liquid storage device liquid flow interface, the liquid storage device liquid flow interface and the liquid storage device The side where the device is connected is provided with a sealing ring; the detection device connection plate is provided with a detection device liquid flow interface and a detection device liquid discharge interface, and the detection device liquid flow interface and the detection device liquid discharge interface are provided. The side connected with the detection device is respectively provided with a sealing ring; the infusion flow channel is used for connecting the liquid flow interface of the liquid storage device and the liquid flow interface of the detection device. The liquid detection switching device of the present invention can make the liquid storage device not directly connected with the detection device, realize fast connection and plugging, and regulate the flow channel at the same time, which greatly reduces the consumption of pipelines and improves the overall equipment efficiency. stability.
Description
Technical Field
The invention relates to the field of fluid treatment, in particular to a liquid detection switching device.
Background
The microfluid detection chip can integrate basic operation units of sample preparation, reaction, separation, detection and the like in the processes of biological, chemical and medical analysis on a micron-scale chip, and automatically complete the whole analysis process. Due to its great potential in the fields of biology, chemistry, medicine and the like, the method has been developed into a new research field crossing the disciplines of biology, chemistry, medicine, fluid, electronics, materials, machinery and the like.
In need carrying the preparation in the medicament bag and the liquid stream sample to detecting the chip, all adopt medicament bag or the direct mode that links to each other with detecting the chip of medicament bottle at present, can influence the liquid stream that directly influences in detecting the chip when changing the medicament bag, poor stability. The design difficulty of the detection chip is high, and from the aspect of processing, the processing tolerance is increased.
Disclosure of Invention
In view of the above-mentioned drawbacks of the prior art, it is an object of the present invention to provide a liquid detection switching apparatus.
To achieve the above and other related objects, a first aspect of the present invention provides a liquid detection adapter, including at least:
the liquid storage device comprises a liquid storage device connecting plate, wherein a liquid storage device liquid flow interface is arranged on the liquid storage device connecting plate, and a sealing ring is arranged on one side of the liquid storage device liquid flow interface, which is connected with the liquid storage device;
the detection device comprises a detection device connecting plate, a detection device liquid flow interface and a detection device liquid drainage interface are arranged on the detection device connecting plate, and sealing rings are respectively arranged on one sides of the detection device liquid flow interface and the detection device liquid drainage interface, which are connected with the detection device;
and the infusion flow channel is used for communicating the liquid flow interface of the liquid storage device with the liquid flow interface of the detection device.
The second aspect of the invention provides the application of the liquid detection adapter device in the field of connection of liquid detection devices.
The third aspect of the present invention provides a liquid detection apparatus and a method of mounting a liquid storage apparatus, including the steps of:
butting a liquid flow outlet of a liquid storage device with a liquid storage device liquid flow interface of the liquid detection adapter device;
and butting a liquid flow inlet of the liquid detection device with a liquid flow interface of the detection device of the liquid detection switching device.
As described above, the liquid detection adapter device of the present invention has the following beneficial effects:
the liquid detection switching device can ensure that the liquid storage device is not directly connected with the detection device, realizes quick connection and plug-in and plug-out, meets the plug-and-play function of the medicament bag, and can also facilitate the replacement of different detection chips below. Meanwhile, the flow channels are structured, the use amount of the pipelines is greatly reduced, the design difficulty of a detection chip is reduced, the machining tolerance is reduced, and the overall stability of the equipment is improved.
Drawings
Fig. 1 is a structural diagram of a liquid detection adapter according to an embodiment of the invention.
Fig. 2 is a front view of a detection device connection plate of the liquid detection adapter according to an embodiment of the present invention.
Fig. 3 is an exploded view of a liquid detection adapter according to an embodiment of the present invention.
Fig. 4 is a structural view of a liquid detection adapter according to another embodiment of the invention.
FIG. 5 is a bottom view of the liquid detecting adapter according to another embodiment of the present invention.
Description of the element reference numerals
1 connecting plate of liquid storage device
11 liquid flow interface of liquid storage device
2 detection device connecting plate
21 detection device liquid flow interface
22 detection device drainage interface
23 hatching cavity arrangement hole
24 detection cavity arrangement hole
25 discharge port
3 transfusion flow passage
4 sample interface
Detailed Description
The following description of the embodiments of the present invention is provided for illustrative purposes, and other advantages and effects of the present invention will become apparent to those skilled in the art from the present disclosure.
Please refer to fig. 1 to 5. It should be understood that the structures, ratios, sizes, and the like shown in the drawings and described in the specification are only used for matching with the disclosure of the specification, so as to be understood and read by those skilled in the art, and are not used to limit the conditions under which the present invention can be implemented, so that the present invention has no technical significance, and any structural modification, ratio relationship change, or size adjustment should still fall within the scope of the present invention without affecting the efficacy and the achievable purpose of the present invention. In addition, the terms "upper", "lower", "left", "right", "middle" and "one" used in the present specification are for clarity of description, and are not intended to limit the scope of the present invention, and the relative relationship between the terms and the terms is not to be construed as a scope of the present invention.
The liquid detection switching device system is a microfluid detection switching device. Specifically, the liquid detection is microfluidic detection, and the total volume of the applicable detection reaction system is not more than 1 ml. The total volume of the detection reaction system is the total volume of the reaction mixture of the sample and the detection preparation. The liquid detection device of the present invention may be a microfluidic detection chip.
As shown in fig. 1, 3 and 4, the liquid detection adapter device of the present invention at least includes:
the liquid storage device comprises a liquid storage device connecting plate 1, wherein a liquid storage device liquid flow interface 11 is arranged on the liquid storage device connecting plate 1, and a sealing ring is arranged on one side, connected with the liquid storage device, of the liquid storage device liquid flow interface 11;
the detection device comprises a detection device connecting plate 2, wherein a detection device liquid flow interface 21 and a detection device liquid drainage interface 22 are arranged on the detection device connecting plate 2, and sealing rings are respectively arranged on one sides, connected with the detection device, of the detection device liquid flow interface 21 and the detection device liquid drainage interface 22;
as shown in fig. 3 and 4, the infusion channel 3 is used for communicating the liquid flow interface 11 of the liquid storage device with the liquid flow interface 21 of the detection device.
The liquid storage device connecting plate is used for being in butt joint with an external liquid storage device. The liquid flow interface of the liquid storage device is used for being in butt joint with a liquid flow outlet on the liquid storage device. The reservoir interface may be adapted to receive a test agent or a sample to be tested. Or may be used only to receive the agent for detection. And the sample to be tested is accessed into the testing device through the sample interface 4, as shown in fig. 2.
The detection device connecting plate is used for being in butt joint with an external detection device. The detection device liquid flow interface is used for being in butt joint with a liquid inlet on the detection device. And (3) the liquid medicine or the sample to be detected is connected into a detection device. The detection device liquid discharge interface is used for being in butt joint with a liquid discharge port of the detection device and receiving liquid discharged from the detection device.
In one embodiment, the detection device connection plate is further provided with a discharge port 25, which is in communication with the detection device liquid discharge port for discharging liquid from the detection device.
In one embodiment, the number of the reservoir fluidic interfaces (11) and the detection device fluidic interfaces (21) is greater than 1. A plurality of liquid storage devices can be connected simultaneously. The centers of the flow ports 11 of the liquid storage devices are on the same straight line. A plurality of liquid storage devices can be inserted simultaneously, and the efficiency is improved.
In one embodiment, the infusion flow passages (3) are not communicated with each other. Prevent the liquid flow in the flow channel from being disordered or preventing the early reaction from influencing the measurement result.
In one embodiment, the liquid storage device flow interface (11) is an outward convex and/or inward concave through hole, and/or the detection device flow interface (21) is an outward convex and/or inward concave through hole. The design can play a limiting role and is convenient to butt joint.
In one embodiment, in the liquid detection and conversion device, only a through hole and a sealing ring arranged at the through hole are arranged at the liquid storage device flow interface (11) and/or the detection device flow interface (21).
In one embodiment, the reservoir flow port (11) is adapted to mate with a reservoir flow outlet and/or the test device flow port (21) is adapted to mate with a test device flow inlet.
Make things convenient for stock solution device flow interface and the direct butt joint of outside stock solution device flow outlet, stock solution device flow outlet sets up in stock solution device flow interface assorted recess or arch, through the direct butt joint of the two to and through the fastening of sealing washer, make the fluid flow in liquid detection switching device, convenient and fast from stock solution device. The liquid flow interface of the detection device is directly butted with the liquid flow inlet of the external liquid detection device. The liquid flow entrance of the liquid detection device is provided with a groove or a bulge matched with the liquid flow interface of the detection device, and the liquid flows into the liquid detection device from the liquid detection switching device through direct butt joint of the groove and the bulge and fastening of the sealing ring, so that convenience and rapidness are realized.
In one embodiment, as shown in fig. 1, the liquid storage device connecting plate 1 and the detection device connecting plate 2 are attached to each other.
In one embodiment, as shown in fig. 1, the reservoir connection plate 1 and the detection device connection plate 2 are thermally compression bonded or glued. Preventing the liquid from leaking.
In one embodiment, as shown in fig. 3, the infusion flow path 3 is provided on the liquid storage device connecting plate 1 or the detection device connecting plate 2.
In one embodiment, as shown in fig. 3, the infusion flow channel is carved on the liquid storage device connecting plate 1 or the detection device connecting plate 2. The engraving design can reduce the inner diameter of the transfusion flow channel to the maximum extent, so that the fine design of the size of the flow channel meets the technical requirements of microfluid.
The inner diameters of through holes on the liquid flow interface 11 of the liquid storage device and the liquid flow interface 21 of the detection device are equal to or smaller than the inner diameter of the infusion flow channel, and a straight line where the circle center of the through hole which is not on the same connecting plate with the infusion flow channel is located is intersected with the central axis of the infusion flow channel, namely the through hole is over against the liquid flow channel, so that liquid in the through hole directly enters the liquid flow channel, and the liquid is prevented from leaking outside.
In one embodiment, the inner diameter of the liquid feeding channel 3 is 0.1 to 1.0 mm. Can be 0.1-0.3mm, 0.3-0.6mm, 0.6-1.0 mm.
In one embodiment, as shown in fig. 4 and 5, the reservoir attachment plate 1 is not directly connected to the test device attachment plate 2.
In one embodiment, as shown in fig. 4 and 5, the connecting plate 1 of the liquid storage device and the connecting plate 2 of the detection device are connected through a transfusion channel 3, and the transfusion channel 3 is a transfusion tube.
In one embodiment, as shown in fig. 4 and 5, the infusion flow channel 3 is communicated with the liquid flow interface 11 of the liquid storage device through an inverted cone connector; and/or the infusion flow channel 3 is communicated with the detection device liquid flow interface 21 through an inverted cone connector.
In one embodiment, the seal ring is a flexible O-ring.
In one embodiment, the sealing ring is selected from one or more of a silicone O-ring, a polytetrafluoroethylene O-ring, a nitrile O-ring, a polyurethane O-ring, or a fluoroelastomer O-ring.
In one embodiment, as shown in fig. 3, 4 and 5, the connection plate of the detection device is provided with an incubation cavity arrangement hole 23 and/or a detection cavity arrangement hole 24; the hatching cavity arrangement hole 23 is matched with a hatching cavity on the detection device, and the detection cavity arrangement hole 24 is matched with a detection cavity on the detection device.
The matching of the hatching cavity arrangement hole 23 and the hatching cavity on the detection device means that the hatching cavity arrangement hole 23 corresponds to the hatching cavity on the detection device in position and devices can be arranged in the hatching cavity through the hatching cavity arrangement hole or the devices above the hatching cavity can extend out through the switching device.
The matching of the detection cavity arrangement hole 24 and the detection cavity on the detection device means that the detection cavity arrangement hole corresponds to the position of the detection cavity on the detection device and can arrange a device such as an optical element to the detection cavity through the detection cavity arrangement hole. Or a device, such as a light element, above the detection chamber may be made to protrude through the adapter means.
In one embodiment, as shown in fig. 1, when the connecting plate 1 of the liquid storage device and the connecting plate 2 of the detection device are engaged with each other, a through hole corresponding to the hole 23 for arranging the hatching chamber and/or the hole 24 for arranging the detection chamber is formed on the connecting plate of the liquid storage device.
In one embodiment, the number of the detection device drain ports 22 is 1.
When in use, the liquid storage device is butted with a liquid storage device liquid flow interface of the liquid detection adapter device; and butting the liquid detection device with a detection device liquid flow interface of the liquid detection switching device. And then carrying out subsequent operations such as detection and the like.
The invention also provides application of the liquid detection adapter device in the field of connection of liquid detection devices. Can be used to connect the microfluidic detection chip with the reservoir device.
The invention provides a liquid detection device and a mounting method of a liquid storage device, comprising the following steps:
butting a liquid flow outlet of a liquid storage device with a liquid storage device liquid flow interface of the liquid detection adapter device;
and butting a liquid flow inlet of the liquid detection device with a liquid flow interface of the detection device of the liquid detection switching device.
Further, the sealing ring of the liquid flow interface of the liquid storage device is pressed on the liquid flow outlet of the liquid storage device, and the sealing ring of the liquid flow interface of the detection device is pressed on the liquid flow inlet of the liquid detection device. The liquid flow outlet of the liquid storage device is arranged in a groove or a bulge matched with the liquid flow interface of the liquid storage device, and fluid flows into the liquid detection switching device from the liquid storage device through direct butt joint of the liquid storage device and the bulge and fastening of the sealing ring. The liquid flow inlet of the liquid detection device is provided with a groove or a bulge matched with the liquid flow interface of the detection device, and the liquid flows into the liquid detection device from the liquid detection switching device through direct butt joint of the groove and the bulge and fastening of the sealing ring.
The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.
Claims (14)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910612164.2A CN112198326A (en) | 2019-07-08 | 2019-07-08 | Liquid detection adapter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910612164.2A CN112198326A (en) | 2019-07-08 | 2019-07-08 | Liquid detection adapter |
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| Publication Number | Publication Date |
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| CN112198326A true CN112198326A (en) | 2021-01-08 |
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| CN201910612164.2A Pending CN112198326A (en) | 2019-07-08 | 2019-07-08 | Liquid detection adapter |
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Citations (7)
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| CN105170206A (en) * | 2015-09-24 | 2015-12-23 | 基蛋生物科技股份有限公司 | Micro-fluidic chip achieving multi-index detection |
| CN105214745A (en) * | 2015-10-26 | 2016-01-06 | 深圳华迈兴微医疗科技有限公司 | A kind of micro-fluidic chip |
| CN106198363A (en) * | 2016-09-13 | 2016-12-07 | 江苏卓微生物科技有限公司 | A kind of FCM analysis chip |
| CN106824006A (en) * | 2017-02-16 | 2017-06-13 | 中国科学院半导体研究所 | A kind of many reagent order feeding devices for preventing cross pollution |
| CN107225006A (en) * | 2017-07-03 | 2017-10-03 | 苏州岚轩生物科技有限公司 | The many flux micro-fluidic chips flowed based on active control liquid |
| CN207507497U (en) * | 2017-09-21 | 2018-06-19 | 深圳市海拓华擎生物科技有限公司 | A kind of micro-fluidic chip |
| CN210894384U (en) * | 2019-07-08 | 2020-06-30 | 上海观流智能科技有限公司 | Liquid detection switching device |
-
2019
- 2019-07-08 CN CN201910612164.2A patent/CN112198326A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105170206A (en) * | 2015-09-24 | 2015-12-23 | 基蛋生物科技股份有限公司 | Micro-fluidic chip achieving multi-index detection |
| CN105214745A (en) * | 2015-10-26 | 2016-01-06 | 深圳华迈兴微医疗科技有限公司 | A kind of micro-fluidic chip |
| CN106198363A (en) * | 2016-09-13 | 2016-12-07 | 江苏卓微生物科技有限公司 | A kind of FCM analysis chip |
| CN106824006A (en) * | 2017-02-16 | 2017-06-13 | 中国科学院半导体研究所 | A kind of many reagent order feeding devices for preventing cross pollution |
| CN107225006A (en) * | 2017-07-03 | 2017-10-03 | 苏州岚轩生物科技有限公司 | The many flux micro-fluidic chips flowed based on active control liquid |
| CN207507497U (en) * | 2017-09-21 | 2018-06-19 | 深圳市海拓华擎生物科技有限公司 | A kind of micro-fluidic chip |
| CN210894384U (en) * | 2019-07-08 | 2020-06-30 | 上海观流智能科技有限公司 | Liquid detection switching device |
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