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CN112168696A - Preparation process of moxifloxacin hydrochloride sodium chloride injection - Google Patents

Preparation process of moxifloxacin hydrochloride sodium chloride injection Download PDF

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Publication number
CN112168696A
CN112168696A CN202011041644.7A CN202011041644A CN112168696A CN 112168696 A CN112168696 A CN 112168696A CN 202011041644 A CN202011041644 A CN 202011041644A CN 112168696 A CN112168696 A CN 112168696A
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sieve plate
filter box
plate
fixed frame
fixedly connected
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Granted
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CN112168696B (en
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龚文卿
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Huaxiashengsheng Pharmaceutical Beijing Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D33/00—Filters with filtering elements which move during the filtering operation
    • B01D33/01—Filters with filtering elements which move during the filtering operation with translationally moving filtering elements, e.g. pistons
    • B01D33/03—Filters with filtering elements which move during the filtering operation with translationally moving filtering elements, e.g. pistons with vibrating filter elements
    • B01D33/0346—Filters with filtering elements which move during the filtering operation with translationally moving filtering elements, e.g. pistons with vibrating filter elements with flat filtering elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D33/00—Filters with filtering elements which move during the filtering operation
    • B01D33/35—Filters with filtering elements which move during the filtering operation with multiple filtering elements characterised by their mutual disposition
    • B01D33/41—Filters with filtering elements which move during the filtering operation with multiple filtering elements characterised by their mutual disposition in series connection
    • B01D33/42—Filters with filtering elements which move during the filtering operation with multiple filtering elements characterised by their mutual disposition in series connection concentrically or coaxially
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D33/00—Filters with filtering elements which move during the filtering operation
    • B01D33/44—Regenerating the filter material in the filter
    • B01D33/48—Regenerating the filter material in the filter by flushing, e.g. counter-current air-bumps
    • B01D33/50—Regenerating the filter material in the filter by flushing, e.g. counter-current air-bumps with backwash arms, shoes or nozzles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2200/00—General characteristics or adaptations
    • A61J2200/40—Heating or cooling means; Combinations thereof
    • A61J2200/42—Heating means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2200/00—General characteristics or adaptations
    • A61J2200/40—Heating or cooling means; Combinations thereof
    • A61J2200/44—Cooling means

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Water Treatment By Sorption (AREA)

Abstract

The invention belongs to the technical field of preparation processes of moxifloxacin hydrochloride and sodium chloride injection, and particularly relates to a preparation process of moxifloxacin hydrochloride and sodium chloride injection, which comprises the following steps: s1: adding sodium hydroxide powder into a stirring tank after sterilization and disinfection, then adding 50% volume of injection water into the stirring tank, and fully stirring to fully dissolve the sodium hydroxide powder to form a uniform solution; s2: heating the temperature in the stirring tank to 90 ℃, then adding moxifloxacin hydrochloride, and uniformly stirring; the invention can accelerate the filtration of the solution containing the active carbon powder, thereby saving the filtration time, improving the filtration efficiency, and controlling the solution adsorbed in the medicinal active carbon powder, thereby improving the generation rate of the solution; meanwhile, the coarse sieve plate and the fine sieve plate can be cleaned conveniently, and the coarse sieve plate and the fine sieve plate can be beaten by the beating mechanism during cleaning, so that particles clamped in the pores of the coarse sieve plate and the fine sieve plate are shaken out, and the cleaning is more thorough.

Description

Preparation process of moxifloxacin hydrochloride sodium chloride injection
Technical Field
The invention belongs to the technical field of a preparation process of moxifloxacin hydrochloride sodium chloride injection, and particularly relates to a preparation process of moxifloxacin hydrochloride sodium chloride injection.
Background
Moxifloxacin hydrochloride is a new broad-spectrum efficient fourth-generation fluoroquinolone antibacterial drug, and a 2005 moxifloxacin hydrochloride sodium chloride injection is marketed in China, and the trade name is as follows: baifule. From the chemical structure, the substituent group at the 7-position of the moxifloxacin is diazabicyclo, so that the drug resistance caused by active discharge of microorganisms can be reduced (which is a main mechanism of cross drug resistance of quinolone drugs), the advantage of low drug resistance is ensured, and the methoxy group is introduced at the 8-position, so that the product retains the original antibacterial activity of the quinolone drugs on gram-negative bacteria, and simultaneously enhances the antibacterial action on gram-positive bacteria, atypical pathogenic bacteria and anaerobic bacteria. Except that the antibacterial activity of the moxifloxacin on pseudomonas aeruginosa is weaker than that of the levofloxacin, the moxifloxacin is stronger than that of the levofloxacin on atypical pathogenic bacteria such as streptococcus pneumoniae, chlamydia, legionella, anaerobic bacteria with spores and without spores and the like. Is clinically used for treating upper respiratory tract and lower respiratory tract infection of adults (more than or equal to 18 years old), such as: acute sinusitis, acute episodes of chronic bronchitis, community-acquired pneumonia, and skin and soft tissue infections. Complex abdominal infections include mixed bacterial infections such as abscesses and the like.
When carrying out the preparation of moxifloxacin hydrochloride sodium chloride injection, there is a must step and just filters the solution that has the active carbon powder to mixing, because active carbon itself belongs to loose porous structure, this will lead to partial solution to remain and go out in the hole of active carbon, solution also can adsorb between the active carbon granule simultaneously, and then the output rate that leads to the solution is lower, and can lead to filtration efficiency lower through the mode of relying on solution gravity whereabouts to filter, can still have partial active carbon granule to remain in the hole of screen cloth after filtering simultaneously, make the washing of screen cloth inconvenient.
Therefore, the invention provides a preparation process of moxifloxacin hydrochloride sodium chloride injection to solve the problems.
Disclosure of Invention
In order to make up for the defects of the prior art, solve the problems that the solution is remained in the pores of the activated carbon and can not be absorbed among the activated carbon particles, so that the yield of the solution is low, and part of the activated carbon particles are remained in the pores of the screen after filtration, so that the screen is inconvenient to clean.
The technical scheme adopted by the invention for solving the technical problems is as follows: the invention relates to a preparation process of moxifloxacin hydrochloride sodium chloride injection, which comprises the following steps:
s1: adding sodium hydroxide powder into a stirring tank after sterilization and disinfection, then adding 50% volume of injection water into the stirring tank, and fully stirring to fully dissolve the sodium hydroxide powder to form a uniform solution;
s2: heating the temperature in the stirring tank to 90 ℃, adding the moxifloxacin hydrochloride with the formula amount, and uniformly stirring;
s3: adding water for injection into the stirring tank until the tank is full, and adjusting the pH to 6.5-7.0 by using 1mol/L hydrochloric acid;
s4: adding medicinal active carbon powder into the stirring tank, controlling the temperature in the stirring tank at 67-85 deg.C, stirring for 25-35min, and cooling to room temperature;
s5: pouring the cooled solution in the step S4 into the filter box from the top of the filter device, then covering a sealing top cover, intermittently extruding a pressing plate above the sealing top cover to enable the solution to rapidly filter the medicinal activated carbon powder through a coarse sieve plate and a fine sieve plate in the filter box, wherein the aperture of the coarse sieve plate is 0.45 mu m, the aperture of the fine sieve plate is 0.22 mu m, the filtered solution is filled into a reagent bottle through a feeding pipe and a liquid outlet pipe at the bottom of the filter box, and then the reagent bottle is sealed;
s6: placing the reagent bottle into a sterilization box for sterilization for 15-20min, wherein the temperature in the sterilization box is 121 ℃;
the filtering device in the S5 comprises a filtering box, a sealing top cover, a discharging pipe, a coarse sieve plate and a fine sieve plate; a sealing top cover is detachably arranged at the top of the filter box; the top of the sealing top cover is fixedly connected with the bottom end of the first spring compression pipe, and the top end of the first spring compression pipe is fixedly connected with the bottom of the pressing plate; a spring for connecting the pressing plate and the sealing top cover is arranged in the first spring compression pipe; a sealing plug is embedded in a liquid feeding port arranged at the top of the first spring compression pipe on the pressing plate; the area, positioned inside the first spring compression pipe, of the top of the sealing top cover is uniformly provided with fluid inlets; a discharging pipe is detachably arranged at the bottom end of the filter box; a liquid outlet pipe is fixedly arranged at the bottom of the blanking pipe; a coarse sieve plate and a fine sieve plate are arranged inside the filter box; the coarse sieve plate is positioned above the fine sieve plate; the outer edges of the coarse sieve plate and the fine sieve plate are both fixedly provided with fixed frames; the outer wall of the fixed frame is provided with a clamping mechanism for clamping the fixed frame on the inner wall of the filter box; a disc-shaped sliding groove is formed in the wall of the filter box at a position corresponding to the fixed frame; a hollow disc is movably arranged in the disc-shaped sliding groove; the outer side surface of the hollow disc is fixedly connected with the inner side end of the rotating handle, and the outer side end of the rotating handle extends out of the outer side wall of the filter box; a first airflow channel is formed in the wall of the filter box above the disc-shaped sliding groove, and a second airflow channel is formed in the wall of the filter box below the disc-shaped sliding groove; a hydrophobic breathable membrane is fixedly arranged inside the lower port of the second airflow channel; the first air flow channel and the second air flow channel are communicated with the interior of the disc-shaped sliding chute; the outer edge of the hollow disc is provided with a group of air inlets; the sizes of the air inlet hole, the first air flow channel and the second air flow channel are matched; the number of the disc-shaped sliding grooves is two, and the disc-shaped sliding grooves are distributed on two opposite side walls of the filter box; the bottom of the fixed frame is provided with a flapping mechanism for flapping the coarse sieve plate and the fine sieve plate;
when the device works, the filtering of the solution containing the medicinal activated carbon powder can be accelerated, so that the filtering time is saved, the filtering efficiency is improved, the solution adsorbed in the medicinal activated carbon powder can be controlled, and the generation rate of the solution is improved; in the actual operation, the solution with the medicinal activated carbon powder is poured into the filter box, then the sealing top cover is covered at the top of the filter box, the pressing plate is repeatedly pressed downwards, the pressing plate can extrude the first spring compression pipe at the bottom of the pressing plate, the gas in the first spring compression pipe enters the filter box through the fluid inlet at the top of the sealing top cover after being compressed, the top of the filter box is pressurized, the solution on the upper surfaces of the coarse sieve plate and the fine sieve plate can be quickly blown down, the filtering efficiency is improved, and in the process of repeated compression and extension of the first spring compression pipe, the flapping mechanism at the bottom of the fixed frame can flap the coarse sieve plate and the fine sieve plate, so that the filtering efficiency of the solution is further improved; meanwhile, the invention is convenient to clean the coarse sieve plate and the fine sieve plate, in actual operation, after solution filtration is finished, a blanking pipe at the bottom of the filter box and a sealing top cover at the top of the filter box can be disassembled, then the sealing top cover is installed at the bottom of the filter box, the filter box is inverted, then a sealing plug on the pressing plate is opened to add injection water into the first spring compression pipe, at the moment, the pressing plate can be pressed intermittently, and then the water in the pressing plate is extruded and sprayed out from the top of the sealing top cover, so that the medicinal activated carbon on the coarse sieve plate and the fine sieve plate is back washed, the cleaning is more efficient, meanwhile, the coarse sieve plate and the fine sieve plate can be beaten by a beating mechanism, particles clamped in the pores of the coarse sieve plate and the fine sieve plate are shaken out, and the cleaning is more thorough.
Preferably, the clamping mechanism comprises a sliding groove, an inserting rod, a cylindrical barrel and a push plate; one end of the cylindrical barrel is fixedly arranged on the outer side wall of the fixed frame; a push plate is movably arranged in the cylindrical barrel; one side of the push plate, which is close to the fixed frame, is fixedly connected with the outer wall of the fixed frame through a spring, and one side of the push plate, which is far away from the fixed frame, is fixedly connected with one end of the insertion rod; the free end of the insertion rod is inserted into the clamping groove in the inner wall of the filter box; the top of the push plate is fixedly connected with the bottom end of the push rod; the push rod is positioned in a sliding groove at the edge of the top of the cylindrical barrel; the top end of the push rod extends out of the top edge of the cylindrical barrel; the during operation, when the installation of coarse sieve board and fine sieve board needs to be carried out, can stir the push pedal to the direction that is close to fixed frame through the push rod earlier, make the peg graft pole shrink in the inside of a cylinder section of thick bamboo, can pack fixed frame into the inside of rose box this moment and make the peg graft pole corresponding with the draw-in groove of rose box inner wall, loosen the push rod that links firmly with the push pedal this moment, under the effort of the spring that links firmly with the push pedal, the peg graft pole inserts the inside of draw-in groove, and then fix the position of fixed frame, thereby fix the position of coarse sieve board and fine sieve board, during the dismantlement, can directly promote the direction that will be close to fixed frame through the push rod, make the peg graft pole shrink in the inside of a cylinder section of thick bamboo, and.
Preferably, a sealing air bag is fixedly arranged at the outer edge of the fixed frame; the sealing air bag bypasses the surface of the cylindrical barrel and is fixedly connected with the surface of the cylindrical barrel; a sealed air cavity is formed inside the sealed air bag; the bottom of the clamping groove is fixedly provided with a compression plate through a spring; the compression plate is fixedly connected with the bottom of the clamping groove through a second spring compression pipe; an air guide channel communicated with the inside of the second spring compression pipe is formed in the insertion rod; the compression plate is provided with a circular through groove for communicating the air guide channel with the interior of the second spring compression pipe; one end of the air guide channel, which is close to the push plate, is communicated with an air cavity in the sealed air bag through a connecting hose; when the sealing device works, when the inserting rod is clamped with the clamping groove, the inserting rod can extrude the compression plate at the bottom of the clamping groove, the compression plate extrudes the second spring compression pipe, gas in the second spring compression pipe is compressed and then enters the gas guide channel in the inserting rod through the circular through groove in the compression plate, and finally enters the sealing air bag through the connecting hose, so that the sealing air bag expands, the sealing performance between the fixed frame and the inner wall of the filter box is better, and the clamping between the fixed frame and the filter box is firmer; because fixed frame is not when installing the inner wall at the rose box through chucking mechanism, when sealed gasbag was in the shriveled state, there was the space between fixed frame of fixed frame and the rose box this moment, consequently is convenient for fixed frame's installation.
Preferably, the flapping mechanism comprises a flapping rod, a spherical air bag and a vertical mounting plate; the top end of the vertical mounting plate is fixedly connected to the bottom of the fixed frame, the bottom end of the vertical mounting plate is movably hinged with one end of the patting rod through a torsion spring, and when the torsion spring is in a natural state, the two groups of patting rods are respectively contacted with the bottoms of the coarse sieve plate and the fine sieve plate; a spherical air bag is fixedly arranged at the position, close to a hinge point, of the top edge of the beating rod, and the spherical air bag is fixedly connected with the bottoms of the coarse sieve plate and the fine sieve plate respectively; the spherical air bag is communicated with the inside of the hollow disc through a connecting hose; an extrusion block is arranged above the connecting hose for connecting the spherical air bag and the hollow disc; the top of the extrusion block is fixedly connected with a second horizontal mounting rod on the inner wall of the filter box through a spring; the connecting hose for connecting the spherical air bag and the hollow disc can be detached; when the filter box is in operation, when the sealing top cover is positioned at the top of the filter box, the repeated compression of the first spring compression pipe plays a role in blowing air to the top of the filter box to promote the filtration of solution; when the first spring compression pipe is compressed intermittently, a part of gas in the first spring compression pipe enters the hollow disc through the first gas flow channel and the gas inlet on the hollow disc, then enters the spherical air bag through the connecting hose, so that the spherical air bag expands, the patting rod moves towards the direction far away from the bottom of the fixed frame, and when the first spring compression pipe is in an extending state, the gas in the spherical air bag is pumped out again, the spherical air bag is in a collapsing state, and the patting rod is contacted with the bottoms of the coarse sieve plate and the fine sieve plate again under the action force of the torsion spring, so that the effects of patting the bottoms of the coarse sieve plate and the fine sieve plate are achieved, and the solution flowing downwards is promoted; when the sealing top cover is positioned at the bottom of the filter box, the repeated compression of the first spring compression pipe plays a role in spraying water to back flush the coarse sieve plate and the fine sieve plate, the handle is rotated at the moment to enable the air inlet hole on the hollow disc to be communicated with the second airflow channel, at the moment, when the first spring compression pipe is compressed intermittently again, partial gas in the first spring compression pipe enters the inside of the second airflow channel through the hydrophobic breathable membrane at the bottom of the second airflow channel and enters the inside of the hollow disc through the air inlet hole, and finally enters the inside of the spherical air bag through the connecting hose to enable the spherical air bag to expand, the patting rod moves towards the direction far away from the coarse sieve plate and the fine sieve plate, and when the first spring compression pipe is in an extending state, the patting rod patts the coarse sieve plate and the fine sieve plate to enable the coarse sieve plate and the fine sieve plate to vibrate, so that medicinal active carbon powder on the coarse sieve plate and the fine sieve plate, meanwhile, the particles embedded in the pores of the coarse sieve plate and the fine sieve plate quickly fall down;
meanwhile, an extrusion block is arranged above the connecting hose for connecting the spherical air bag and the hollow disc; the top of the extrusion block is fixedly connected with a second horizontal mounting rod of the inner wall of the filter box through a spring, and further when the hollow disc needs to be rotated again through a rotating handle (the length of the connecting hose used for connecting the spherical air bag and the hollow disc is enough to complete the operation), the connecting hose drawn into the disc-shaped chute at the moment can be uniformly drawn out under the action of the extrusion block, and the connecting hose used for connecting the spherical air bag and the hollow disc can be split, so that when the coarse sieve plate and the fine sieve plate need to be disassembled from the inside of the filter box, the connecting hose used for connecting the spherical air bag and the hollow disc can be split to realize the operation.
Preferably, a circular sleeve is movably sleeved on the outer side of the beating rod; a circular gear ring is fixedly arranged at the edge of the outer side end of the circular sleeve; the circular gear ring and the arc gear plate are in meshed transmission with each other; the bottom end of the arc gear plate is fixedly connected to the upper surface of a first horizontal mounting rod on the inner wall of the filter box; the arc gear plate is made of a tough material; when the beating rod swings up and down and beats the coarse sieve plate and the fine sieve plate, the circular gear ring arranged at the end part of the circular sleeve outside the beating rod can be meshed with the second spring compression pipe for transmission, and then the circular sleeve is driven to rotate, so that the surface of the circular sleeve can be cleaned when the coarse sieve plate and the fine sieve plate are backwashed, and the cleaning dead angle is avoided.
Preferably, an indicating needle is fixedly arranged on the rotating handle and positioned on the outer side of the filter box; the outer wall of the filter box is provided with a scale groove at the position corresponding to the central axis of the first airflow channel and the central axis of the second airflow channel; in the process of rotating the rotating handle, the indicating needle can be superposed with the scale groove; when the air inlet device works, the air inlet hole in the hollow disc is controlled to be aligned with the first air flow channel or the second air flow channel through the rotation of the rotating handle, and whether the air inlet hole in the hollow disc corresponds to the port of the first air flow channel or the port of the second air flow channel can be accurately determined through the combination of the indicating needle and the scale groove.
The invention has the following beneficial effects:
1. the invention relates to a preparation process of moxifloxacin hydrochloride sodium chloride injection, which comprises the steps of arranging a sealing top cover and a first spring compression pipe, repeatedly compressing the first spring compression pipe during solution filtration, blowing air to the top of a filter box to further accelerate the filtration efficiency of the solution, detaching a blanking pipe at the bottom of the filter box and the sealing top cover at the top of the filter box after the solution filtration is finished, then installing the sealing top cover at the bottom of the filter box, inverting the filter box, adding injection water into the first spring compression pipe, intermittently pressing the first spring compression pipe to enable the first spring compression pipe to spray water into the filter box for back flushing medicinal activated carbon on a coarse sieve plate and a fine sieve plate, enabling the cleaning to be more efficient, and beating the coarse sieve plate and the fine sieve plate through a beating mechanism during the cleaning, and the particles clamped in the pores of the coarse sieve plate and the fine sieve plate are vibrated out, so that the cleaning is more thorough.
2. According to the preparation process of the moxifloxacin hydrochloride sodium chloride injection, the flapping mechanism is arranged, and can intermittently flap the bottoms of the coarse sieve plate and the fine sieve plate, so that the effect of accelerating solution filtration can be achieved when the solution is filtered, and medicinal activated carbon particles in the coarse sieve plate and the fine sieve plate can be beaten out when the coarse sieve plate and the fine sieve plate are backwashed, so that the cleaning efficiency of the coarse sieve plate and the fine sieve plate is improved.
3. According to the preparation process of the moxifloxacin hydrochloride sodium chloride injection, the clamping mechanism is arranged, when a coarse sieve plate and a fine sieve plate need to be installed, the inserting rod can be contracted inside the cylindrical barrel by poking the push rod, the inserting rod can correspond to the clamping groove in the inner wall of the filter box at the moment, then the push rod fixedly connected with the push plate is loosened, the inserting rod is inserted into the clamping groove under the action of the spring fixedly connected with the push plate and is further fixed, when the inserting rod and the clamping groove are mutually clamped, the sealing air bag positioned at the edge of the fixed frame expands, the sealing performance between the fixed frame and the inner wall of the filter box is further better, and meanwhile, the clamping between the fixed frame and the filter box is firmer.
Drawings
The invention will be further explained with reference to the drawings.
FIG. 1 is a process diagram of the preparation of moxifloxacin hydrochloride sodium chloride injection of the present invention;
FIG. 2 is a schematic view of the construction of the filter apparatus of the present invention;
FIG. 3 is a schematic view showing the internal structure of the filter device of the present invention;
FIG. 4 is an enlarged view of a portion of FIG. 3 at A;
FIG. 5 is an enlarged view of a portion of FIG. 3 at B;
FIG. 6 is an enlarged view of a portion of FIG. 3 at C;
in the figure: the device comprises a filter box 1, a sealing top cover 2, a blanking pipe 3, a liquid outlet pipe 4, a pressing plate 5, a sealing plug 6, a first spring compression pipe 7, a fluid inlet 8, an indicating needle 10, a scale groove 11, a first air flow channel 12, a coarse sieve plate 13, a fine sieve plate 14, a second air flow channel 15, a fixed frame 16, a sealing air bag 17, a push rod 18, a sliding groove 19, a compression plate 20, a second spring compression pipe 21, a clamping groove 22, an air guide channel 23, a plug rod 24, a beating rod 25, a spherical air bag 26, an arc gear plate 27, a circular gear ring 28, a circular sleeve 30, a first horizontal mounting rod 31, a disc-shaped sliding groove 32, an air inlet 33, a hollow disc 34, a hydrophobic air-permeable diaphragm 35, a cylindrical barrel 36, a push plate 37, a vertical mounting plate 38, an extrusion block 39, a second horizontal mounting rod 40 and a.
Detailed Description
In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further described with the specific embodiments.
As shown in fig. 1 to fig. 6, the preparation process of moxifloxacin hydrochloride sodium chloride injection provided by the invention specifically comprises the following steps:
s1: adding sodium hydroxide powder into a stirring tank after sterilization and disinfection, then adding 50% volume of injection water into the stirring tank, and fully stirring to fully dissolve the sodium hydroxide powder to form a uniform solution;
s2: heating the temperature in the stirring tank to 90 ℃, adding the moxifloxacin hydrochloride with the formula amount, and uniformly stirring;
s3: adding water for injection into the stirring tank until the tank is full, and adjusting the pH to 6.5-7.0 by using 1mol/L hydrochloric acid;
s4: adding medicinal active carbon powder into the stirring tank, controlling the temperature in the stirring tank at 67-85 deg.C, stirring for 25-35min, and cooling to room temperature;
s5: pouring the cooled solution in the S4 into the inside of a filter box 1 from the top of the filter device, then covering a sealing top cover 2, intermittently pressing a pressing plate 5 above the sealing top cover 2 to enable the solution to rapidly filter medicinal activated carbon powder through a coarse sieve plate 13 and a fine sieve plate 14 in the filter box 1, wherein the aperture of the coarse sieve plate 13 is 0.45 mu m, the aperture of the fine sieve plate 14 is 0.22 mu m, the filtered solution is filled into a reagent bottle through a feeding pipe 3 and a liquid outlet pipe 4 at the bottom of the filter box 1, and then the reagent bottle is sealed;
s6: placing the reagent bottle into a sterilization box for sterilization for 15-20min, wherein the temperature in the sterilization box is 121 ℃;
the filtering device in the S5 comprises a filtering box 1, a sealing top cover 2, a blanking pipe 3, a coarse sieve plate 13 and a fine sieve plate 14; a sealing top cover 2 is detachably arranged at the top of the filter box 1; the top of the sealing top cover 2 is fixedly connected with the bottom end of a first spring compression pipe 7, and the top end of the first spring compression pipe 7 is fixedly connected with the bottom of the pressing plate 5; a spring for connecting the pressing plate 5 and the sealing top cover 2 is arranged in the first spring compression pipe 7; a sealing plug 6 is embedded in a liquid feeding port arranged at the top of the first spring compression pipe 7 on the pressing plate 5; the area, positioned inside the first spring compression pipe 7, of the top of the sealing top cover 2 is uniformly provided with fluid inlets 8; a discharging pipe 3 is detachably arranged at the bottom end of the filter box 1; a liquid outlet pipe 4 is fixedly arranged at the bottom of the blanking pipe 3; a coarse sieve plate 13 and a fine sieve plate 14 are arranged inside the filter box 1; the coarse sieve plate 13 is positioned above the fine sieve plate 14; the outer edges of the coarse sieve plate 13 and the fine sieve plate 14 are both fixedly provided with a fixed frame 16; the outer wall of the fixed frame 16 is provided with a clamping mechanism for clamping the fixed frame 16 on the inner wall of the filter box 1; a disc-shaped sliding groove 32 is formed in the wall of the filter box 1 at a position corresponding to the fixed frame 16; a hollow disc 34 is movably arranged in the disc-shaped sliding chute 32; the outer side surface of the hollow disc 34 is fixedly connected with the inner side end of the rotating handle 41, and the outer side end of the rotating handle 41 extends out of the outer side wall of the filter box 1; a first airflow channel 12 is arranged above the disc-shaped chute 32 in the wall of the filter box 1, and a second airflow channel 15 is arranged below the disc-shaped chute 32 in the wall of the filter box 1; a hydrophobic breathable membrane 35 is fixedly arranged inside the lower port of the second airflow channel 15; the first air flow passage 12 and the second air flow passage 15 are both communicated with the inside of the disc-shaped chute 32; the outer edge of the hollow disc 34 is provided with a group of air inlet holes 33; the sizes of the air inlet hole 33 and the first air flow channel 12 and the second air flow channel 15 are matched; the number of the disc-shaped chutes 32 is two, and the disc-shaped chutes 32 are distributed on two opposite side walls of the filter box 1; a beating mechanism for beating the coarse sieve plate 13 and the fine sieve plate 14 is arranged at the bottom of the fixed frame 16;
when the device works, the filtering of the solution containing the medicinal activated carbon powder can be accelerated, so that the filtering time is saved, the filtering efficiency is improved, the solution adsorbed in the medicinal activated carbon powder can be controlled, and the generation rate of the solution is improved; in actual operation, a solution containing medicinal activated carbon powder is poured into the filter box 1, the sealing top cover 2 is covered on the top of the filter box 1, the pressing plate 5 is repeatedly pressed downwards, the pressing plate 5 can press the first spring compression pipe 7 located at the bottom of the pressing plate, gas inside the first spring compression pipe 7 enters the filter box 1 through the fluid inlet 8 in the top of the sealing top cover 2 after being compressed, the top of the filter box 1 is pressurized, the solution located on the upper surfaces of the coarse sieve plate 13 and the fine sieve plate 14 can be quickly blown down, the filtering efficiency is further improved, and in the repeated compression and extension process of the first spring compression pipe 7, the flapping mechanism located at the bottom of the fixed frame 16 can flap the coarse sieve plate 13 and the fine sieve plate 14, and the filtering efficiency of the solution is further improved; meanwhile, the invention is convenient for cleaning the coarse sieve plate 13 and the fine sieve plate 14, and in the actual operation, after the solution filtration is finished, the blanking pipe 3 at the bottom of the filter box 1 and the sealing top cover 2 at the top of the filter box 1 can be disassembled, then the sealing top cover 2 is arranged at the bottom of the filter box 1, the filter box 1 is inverted, then the sealing plug 6 on the pressing plate 5 is opened to add the water for injection into the first spring compression pipe 7, at the moment, the pressing plate 5 can be pressed intermittently, further, water in the pressing plate 5 is extruded and sprayed out from the top of the sealing top cover 2 for back washing the medicinal activated carbon on the coarse sieve plate 13 and the fine sieve plate 14, so that the cleaning is more efficient, meanwhile, the coarse sieve plate 13 and the fine sieve plate 14 can be beaten by the beating mechanism during cleaning, and particles clamped in the holes of the coarse sieve plate 13 and the fine sieve plate 14 are shaken out, so that the cleaning is more thorough.
As an embodiment of the present invention, the chucking mechanism includes a sliding groove 19, a plug rod 24, a cylindrical barrel 36, and a push plate 37; one end of the cylindrical barrel 36 is fixedly arranged on the outer side wall of the fixed frame 16; a push plate 37 is movably arranged in the cylindrical barrel 36; one side of the push plate 37, which is close to the fixed frame 16, is fixedly connected with the outer wall of the fixed frame 16 through a spring, and one side of the push plate 37, which is far away from the fixed frame 16, is fixedly connected with one end of the insertion rod 24; the free end of the insertion rod 24 is inserted into the clamping groove 22 on the inner wall of the filter box 1; the top of the push plate 37 is fixedly connected with the bottom end of the push rod 18; the push rod 18 is positioned in a sliding groove 19 at the top edge of the cylindrical barrel 36; the top end of the push rod 18 extends out of the top edge of the cylindrical barrel 36; during operation, when the installation of coarse sieve plate 13 and fine sieve plate 14 needs to be carried out, push plate 37 can be shifted to the direction close to fixed frame 16 through push rod 18 first, make bayonet catch bar 24 shrink in the inside of a cylinder 36, can pack fixed frame 16 into the inside of rose box 1 and make bayonet catch bar 24 and rose box 1 inner wall's draw-in groove 22 corresponding this moment, loosen the push rod 18 of linking with push plate 37 this moment, under the effort of the spring that links firmly with push plate 37, bayonet catch bar 24 inserts the inside of draw-in groove 22, and then fix the position of fixed frame 16, thereby fix the position of coarse sieve plate 13 and fine sieve plate 14, during the dismantlement, can directly promote the direction close to fixed frame 16 through push rod 18, make bayonet catch bar 24 shrink in the inside of a cylinder 36, and then can take out fixed frame 16 easily.
As an embodiment of the present invention, a sealing air bag 17 is fixedly disposed at an outer edge of the fixed frame 16; the sealing air bag 17 bypasses the surface of the cylindrical barrel 36 and is fixedly connected with the surface of the cylindrical barrel 36; a sealed air cavity is formed inside the sealed air bag 17; the bottom of the clamping groove 22 is fixedly provided with a compression plate 20 through a spring; the compression plate 20 is fixedly connected with the bottom of the clamping groove 22 through a second spring compression pipe 21; an air guide channel 23 communicated with the inside of the second spring compression pipe 21 is formed in the insertion rod 24; a circular through groove for communicating the air guide channel 23 with the interior of the second spring compression pipe 21 is formed in the compression plate 20; one end of the air guide channel 23 close to the push plate 37 is communicated with an air cavity in the sealed air bag 17 through a connecting hose; when the air bag type air bag filter box works, when the inserting rod 24 and the clamping groove 22 are mutually clamped, the inserting rod 24 can extrude the compression plate 20 positioned at the bottom of the clamping groove 22, the compression plate 20 extrudes the second spring compression pipe 21, air in the second spring compression pipe 21 is compressed and then enters the air guide channel 23 in the inserting rod 24 through the circular through groove in the compression plate 20, and finally enters the sealing air bag 17 through the connecting hose, so that the sealing air bag 17 expands, the sealing performance between the fixed frame 16 and the inner wall of the filter box 1 is better, and the clamping between the fixed frame 16 and the filter box 1 is firmer; when the fixing frame 16 is not mounted on the inner wall of the filter box 1 by the clamping mechanism and the air bag 17 is in the collapsed state, a gap exists between the fixing frame 16 of the fixing frame 16 and the filter box 1, so that the fixing frame 16 is convenient to mount.
As an embodiment of the present invention, the flapping mechanism comprises a flapping rod 25, a spherical air bag 26 and a vertical mounting plate 38; the top end of the vertical mounting plate 38 is fixedly connected to the bottom of the fixed frame 16, the bottom end of the vertical mounting plate 38 is movably hinged to one end of the beating rods 25 through torsion springs, and when the torsion springs are in a natural state, the two groups of beating rods 25 are respectively contacted with the bottoms of the coarse sieve plate 13 and the fine sieve plate 14; a spherical air bag 26 is fixedly arranged at the position, close to a hinge point, of the top edge of the beating rod 25, and the spherical air bag 26 is fixedly connected with the bottoms of the coarse sieve plate 13 and the fine sieve plate 14 respectively; the spherical air bag 26 is communicated with the interior of the hollow disc 34 through a connecting hose; an extrusion block 39 is arranged above the connecting hose for connecting the spherical air bag 26 and the hollow disc 34; the top of the extrusion block 39 is fixedly connected with a second horizontal mounting rod 40 on the inner wall of the filter box 1 through a spring; the connecting hose for connecting the spherical air bag 26 and the hollow disc 34 is detachable; when the filter box is in operation, when the sealing top cover 2 is positioned at the top of the filter box 1, the repeated compression of the first spring compression pipe 7 plays a role in blowing air to the top of the filter box 1 to promote the filtration of the solution; when the first spring compression pipe 7 is intermittently compressed, a part of the gas inside the first spring compression pipe 7 enters the inside of the hollow disc 34 through the first gas flow passage 12 and the gas inlet hole 33 on the hollow disc 34, and then enters the inside of the spherical airbag 26 through the connecting hose, so that the spherical airbag 26 expands, and the patting rod 25 moves in a direction away from the bottom of the fixed frame 16, and when the first spring compression pipe 7 is in an extended state, the gas inside the spherical airbag 26 is pumped out again, the spherical airbag 26 is in a collapsed state, and the patting rod 25 contacts with the bottom of the coarse sieve plate 13 and the bottom of the fine sieve plate 14 again under the action of the torsion spring, so that the bottom of the coarse sieve plate 13 and the bottom of the fine sieve plate 14 are patted, and the solution flows downwards; when the sealing top cover 2 is positioned at the bottom of the filter box 1, the repeated compression of the first spring compression pipe 7 plays a role of spraying water to back flush the coarse sieve plate 13 and the fine sieve plate 14, at the moment, the rotating handle 41 is rotated to enable the air inlet 33 on the hollow disc 34 to be communicated with the second air flow channel 15, at the moment, when the first spring compression pipe 7 is compressed intermittently again, part of air in the first spring compression pipe 7 enters the inside of the second air flow channel 15 through the hydrophobic air-permeable membrane 35 at the bottom of the second air flow channel 15, enters the inside of the hollow disc 34 through the air inlet 33, finally enters the inside of the spherical air bag 26 through the connecting hose, so that the spherical air bag 26 is expanded, the beating rod 25 moves towards the direction far away from the coarse sieve plate 13 and the fine sieve plate 14, and when the first spring compression pipe 7 is in an extending state, the beating rod 25 beats the coarse sieve plate 13 and the fine sieve plate 14, vibrating the coarse sieve plate 13 and the fine sieve plate 14, so that the medicinal activated carbon powder on the coarse sieve plate 13 and the fine sieve plate 14 quickly falls, and simultaneously, the particles embedded in the pores of the coarse sieve plate 13 and the fine sieve plate 14 quickly fall;
meanwhile, as the extrusion block 39 is arranged above the connecting hose for connecting the spherical air bag 26 and the hollow disc 34; the top of the squeezing block 39 is fixedly connected with the second horizontal mounting rod 40 on the inner wall of the filtering box 1 through a spring, so that when the hollow disc 34 needs to be turned around again through the turning handle 41 (the length of the connecting hose for connecting the spherical air bag 26 and the hollow disc 34 is enough to complete the operation), the connecting hose wound inside the disc-shaped chute 32 can be uniformly drawn out under the action of the squeezing block 39, and because the connecting hose for connecting the spherical air bag 26 and the hollow disc 34 can be disassembled, when the coarse sieve plate 13 and the fine sieve plate 14 need to be disassembled from the inside of the filtering box 1, the connecting hose for connecting the spherical air bag 26 and the hollow disc 34 can be disassembled at the moment.
As an embodiment of the invention, a circular sleeve 30 is movably sleeved on the outer side of the beating rod 25; a circular gear ring 28 is fixedly arranged at the edge of the outer side end of the circular sleeve 30; the circular gear ring 28 and the arc gear plate 27 are in meshed transmission with each other; the bottom end of the arc gear plate 27 is fixedly connected to the upper surface of a first horizontal mounting rod 31 on the inner wall of the filter box 1; the arc gear plate 27 is made of a tough material; when the device works, the flapping rod 25 swings up and down and flaps the coarse sieve plate 13 and the fine sieve plate 14, and meanwhile, the circular gear ring 28 arranged at the end part of the circular sleeve 30 positioned outside the flapping rod 25 is meshed with the second spring compression pipe 21 for transmission, so that the circular sleeve 30 is driven to rotate, the surface of the circular sleeve 30 can be cleaned when the coarse sieve plate 13 and the fine sieve plate 14 are backwashed, and the cleaning dead angle is avoided.
In one embodiment of the present invention, an indicator needle 10 is fixedly disposed on the rotating handle 41 and located outside the filter tank 1; the outer wall of the filter box 1 is provided with a scale groove 11 at the position corresponding to the central axis of the first airflow channel 12 and the second airflow channel 15; in the process of rotating the rotating handle 41, the indicating needle 10 can be overlapped with the scale groove 11; in operation, since it is necessary to control the air inlet hole 33 on the hollow circular disc 34 to be aligned with the first air flow passage 12 or the second air flow passage 15 by rotating the rotating handle 41, whether the air inlet hole 33 on the hollow circular disc 34 corresponds to the port of the first air flow passage 12 or the second air flow passage 15 can be accurately determined by the combination of the indicating needle 10 and the scale groove 11.
The specific working process of the invention is as follows:
when the device works, the filtering of the solution containing the medicinal activated carbon powder can be accelerated, so that the filtering time is saved, the filtering efficiency is improved, the solution adsorbed in the medicinal activated carbon powder can be controlled, and the generation rate of the solution is improved; in actual operation, a solution containing medicinal activated carbon powder is poured into the filter box 1, the sealing top cover 2 is covered on the top of the filter box 1, the pressing plate 5 is repeatedly pressed downwards, the pressing plate 5 can press the first spring compression pipe 7 located at the bottom of the pressing plate, gas inside the first spring compression pipe 7 enters the filter box 1 through the fluid inlet 8 in the top of the sealing top cover 2 after being compressed, the top of the filter box 1 is pressurized, the solution located on the upper surfaces of the coarse sieve plate 13 and the fine sieve plate 14 can be quickly blown down, the filtering efficiency is further improved, and in the repeated compression and extension process of the first spring compression pipe 7, the flapping mechanism located at the bottom of the fixed frame 16 can flap the coarse sieve plate 13 and the fine sieve plate 14, and the filtering efficiency of the solution is further improved; meanwhile, the invention is convenient for cleaning the coarse sieve plate 13 and the fine sieve plate 14, and in the actual operation, after the solution filtration is finished, the blanking pipe 3 at the bottom of the filter box 1 and the sealing top cover 2 at the top of the filter box 1 can be disassembled, then the sealing top cover 2 is arranged at the bottom of the filter box 1, the filter box 1 is inverted, then the sealing plug 6 on the pressing plate 5 is opened to add the water for injection into the first spring compression pipe 7, at the moment, the pressing plate 5 can be pressed intermittently, further, water in the pressing plate 5 is extruded and sprayed out from the top of the sealing top cover 2 for back washing the medicinal activated carbon on the coarse sieve plate 13 and the fine sieve plate 14, so that the cleaning is more efficient, meanwhile, the coarse sieve plate 13 and the fine sieve plate 14 can be beaten by the beating mechanism during cleaning, and particles clamped in the holes of the coarse sieve plate 13 and the fine sieve plate 14 are shaken out, so that the cleaning is more thorough.
The foregoing illustrates and describes the principles, general features, and advantages of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims (6)

1. A preparation process of moxifloxacin hydrochloride sodium chloride injection is characterized in that: the method specifically comprises the following steps:
s1: adding sodium hydroxide powder into a stirring tank after sterilization and disinfection, then adding 50% volume of injection water into the stirring tank, and fully stirring to fully dissolve the sodium hydroxide powder to form a uniform solution;
s2: heating the temperature in the stirring tank to 90 ℃, adding the moxifloxacin hydrochloride with the formula amount, and uniformly stirring;
s3: adding water for injection into the stirring tank until the tank is full, and adjusting the pH to 6.5-7.0 by using 1mol/L hydrochloric acid;
s4: adding medicinal active carbon powder into the stirring tank, controlling the temperature in the stirring tank at 67-85 deg.C, stirring for 25-35min, and cooling to room temperature;
s5: pouring the cooled solution in the S4 into the inside of a filter box (1) from the top of a filter device, then covering a sealing top cover (2), intermittently pressing a pressing plate (5) above the sealing top cover (2) to enable the solution to rapidly filter medicinal activated carbon powder through a coarse sieve plate (13) and a fine sieve plate (14) in the filter box (1), wherein the aperture of the coarse sieve plate (13) is 0.45 mu m, the aperture of the fine sieve plate (14) is 0.22 mu m, the filtered solution is filled into a reagent bottle through a discharging pipe (3) and a discharging pipe (4) at the bottom of the filter box (1), and then sealing the reagent bottle;
s6: placing the reagent bottle into a sterilization box for sterilization for 15-20min, wherein the temperature in the sterilization box is 121 ℃;
the filtering device in the S5 comprises a filtering box (1), a sealing top cover (2), a blanking pipe (3), a coarse sieve plate (13) and a fine sieve plate (14); a sealing top cover (2) is detachably arranged at the top of the filter box (1); the top of the sealing top cover (2) is fixedly connected with the bottom end of a first spring compression pipe (7), and the top end of the first spring compression pipe (7) is fixedly connected with the bottom of the pressing plate (5); a spring used for connecting the pressing plate (5) and the sealing top cover (2) is arranged in the first spring compression pipe (7); a sealing plug (6) is embedded in a liquid feeding port arranged at the top of the first spring compression pipe (7) on the pressing plate (5); the area, positioned inside the first spring compression pipe (7), of the top of the sealing top cover (2) is uniformly provided with fluid inlets (8); a blanking pipe (3) is detachably arranged at the bottom end of the filter box (1); a liquid outlet pipe (4) is fixedly arranged at the bottom of the blanking pipe (3); a coarse sieve plate (13) and a fine sieve plate (14) are arranged in the filter box (1); the coarse sieve plate (13) is positioned above the fine sieve plate (14); the outer edges of the coarse sieve plate (13) and the fine sieve plate (14) are both fixedly provided with fixed frames (16); the outer wall of the fixed frame (16) is provided with a clamping mechanism for clamping the fixed frame (16) on the inner wall of the filter box (1); a disc-shaped sliding groove (32) is formed in the wall of the filter box (1) at a position corresponding to the fixed frame (16); a hollow disc (34) is movably arranged in the disc-shaped sliding groove (32); the outer side surface of the hollow disc (34) is fixedly connected with the inner side end of the rotating handle (41), and the outer side end of the rotating handle (41) extends out of the outer side wall of the filter box (1); a first air flow channel (12) is formed in the wall of the filter box (1) above the disc-shaped sliding groove (32), and a second air flow channel (15) is formed in the wall of the filter box (1) below the disc-shaped sliding groove (32); a hydrophobic breathable membrane (35) is fixedly arranged inside the lower port of the second airflow channel (15); the first air flow channel (12) and the second air flow channel (15) are both communicated with the interior of the disc-shaped chute (32); the outer edge of the hollow disc (34) is provided with a group of air inlet holes (33); the air inlet hole (33) is matched with the sizes of the first air flow channel (12) and the second air flow channel (15); the number of the disc-shaped chutes (32) is two, and the disc-shaped chutes (32) are distributed on two opposite side walls of the filter box (1); the bottom of the fixed frame (16) is provided with a beating mechanism for beating the coarse sieve plate (13) and the fine sieve plate (14).
2. The preparation process of moxifloxacin hydrochloride sodium chloride injection according to claim 1, which is characterized in that: the clamping mechanism comprises a sliding groove (19), an inserting rod (24), a cylindrical barrel (36) and a push plate (37); one end of the cylindrical barrel (36) is fixedly arranged on the outer side wall of the fixed frame (16); a push plate (37) is movably arranged in the cylindrical barrel (36); one side, close to the fixed frame (16), of the push plate (37) is fixedly connected with the outer wall of the fixed frame (16) through a spring, and one side, far away from the fixed frame (16), of the push plate (37) is fixedly connected with one end of the insertion rod (24); the free end of the insertion rod (24) is inserted into a clamping groove (22) in the inner wall of the filter box (1); the top of the push plate (37) is fixedly connected with the bottom end of the push rod (18); the push rod (18) is positioned in a sliding groove (19) at the top edge of the cylindrical barrel (36); the top end of the push rod (18) extends out of the top edge of the cylindrical barrel (36).
3. The preparation process of moxifloxacin hydrochloride sodium chloride injection according to claim 2, characterized in that: a sealing air bag (17) is fixedly arranged at the outer edge of the fixed frame (16); the sealing air bag (17) bypasses the surface of the cylindrical barrel (36) and is fixedly connected with the surface of the cylindrical barrel (36); a sealed air cavity is formed inside the sealed air bag (17); the bottom of the clamping groove (22) is fixedly provided with a compression plate (20) through a spring; the compression plate (20) is fixedly connected with the bottom of the clamping groove (22) through a second spring compression pipe (21); an air guide channel (23) communicated with the inside of the second spring compression pipe (21) is formed in the insertion rod (24); the compression plate (20) is provided with a circular through groove for communicating the air guide channel (23) with the interior of the second spring compression pipe (21); one end of the air guide channel (23) close to the push plate (37) is communicated with an air cavity inside the sealed air bag (17) through a connecting hose.
4. The preparation process of moxifloxacin hydrochloride sodium chloride injection according to claim 1, which is characterized in that: the flapping mechanism comprises a flapping rod (25), a spherical air bag (26) and a vertical mounting plate (38); the top end of the vertical mounting plate (38) is fixedly connected to the bottom of the fixed frame (16), the bottom end of the vertical mounting plate (38) is movably hinged with one end of the beating rods (25) through torsion springs, and when the torsion springs are in a natural state, the two groups of beating rods (25) are respectively contacted with the bottoms of the coarse sieve plate (13) and the fine sieve plate (14); a spherical air bag (26) is fixedly arranged at the position, close to a hinge point, of the top edge of the beating rod (25), and the spherical air bag (26) is fixedly connected with the bottoms of the coarse sieve plate (13) and the fine sieve plate (14) respectively; the spherical air bag (26) is communicated with the inside of the hollow disc (34) through a connecting hose; an extrusion block (39) is arranged above the connecting hose for connecting the spherical air bag (26) and the hollow disc (34); the top of the extrusion block (39) is fixedly connected with a second horizontal mounting rod (40) on the inner wall of the filter box (1) through a spring; the connecting hose for connecting the spherical air bag (26) and the hollow disc (34) can be disassembled.
5. The preparation process of moxifloxacin hydrochloride sodium chloride injection according to claim 4, characterized in that: a circular sleeve (30) is movably sleeved on the outer side of the beating rod (25); a circular gear ring (28) is fixedly arranged at the edge of the outer side end of the circular sleeve (30); the circular gear ring (28) and the arc gear plate (27) are in meshed transmission; the bottom end of the arc gear plate (27) is fixedly connected to the upper surface of a first horizontal mounting rod (31) on the inner wall of the filter box (1); the arc gear plate (27) is made of a tough material.
6. The preparation process of moxifloxacin hydrochloride sodium chloride injection according to claim 1, which is characterized in that: an indicating needle (10) is fixedly arranged on the rotating handle (41) and positioned on the outer side of the filter box (1); the outer wall of the filter box (1) is provided with a scale groove (11) at a position corresponding to the central axis of the first airflow channel (12) and the central axis of the second airflow channel (15); in the process of rotating the rotating handle (41), the indicating needle (10) can be overlapped with the scale groove (11).
CN202011041644.7A 2020-09-28 2020-09-28 Preparation process of moxifloxacin hydrochloride sodium chloride injection Active CN112168696B (en)

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CN114146127A (en) * 2021-12-09 2022-03-08 上海左耳零医疗科技有限公司 Female bacteriostatic lotion for treating HPV (human papillomavirus) by plant compound prescription and preparation method thereof
CN115193317A (en) * 2022-07-13 2022-10-18 海南卓科制药有限公司 Amiodarone hydrochloride injection preparation equipment and preparation process thereof
CN115193317B (en) * 2022-07-13 2024-01-16 海南卓科制药有限公司 Amiodarone hydrochloride injection liquid preparation equipment and preparation process thereof

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