CN112155795A - Material-additive manufacturing titanium alloy zoned bone trabecula artificial hip joint sleeve and preparation method - Google Patents
Material-additive manufacturing titanium alloy zoned bone trabecula artificial hip joint sleeve and preparation method Download PDFInfo
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- CN112155795A CN112155795A CN202011190156.2A CN202011190156A CN112155795A CN 112155795 A CN112155795 A CN 112155795A CN 202011190156 A CN202011190156 A CN 202011190156A CN 112155795 A CN112155795 A CN 112155795A
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- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 150
- 229910001069 Ti alloy Inorganic materials 0.000 title claims abstract description 74
- 210000004394 hip joint Anatomy 0.000 title claims abstract description 51
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 50
- 239000000654 additive Substances 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title abstract description 11
- 239000013067 intermediate product Substances 0.000 claims abstract description 56
- 230000000996 additive effect Effects 0.000 claims abstract description 38
- 238000001816 cooling Methods 0.000 claims abstract description 38
- 239000000843 powder Substances 0.000 claims abstract description 19
- 238000010146 3D printing Methods 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 8
- 238000000034 method Methods 0.000 claims abstract description 7
- 238000001513 hot isostatic pressing Methods 0.000 claims abstract description 6
- 238000010438 heat treatment Methods 0.000 claims description 21
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 20
- 210000001624 hip Anatomy 0.000 claims description 14
- 239000007788 liquid Substances 0.000 claims description 10
- 229910052757 nitrogen Inorganic materials 0.000 claims description 10
- 238000003754 machining Methods 0.000 claims description 7
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 6
- 239000010936 titanium Substances 0.000 claims description 6
- 239000012535 impurity Substances 0.000 claims description 5
- 238000009966 trimming Methods 0.000 claims description 5
- 239000001307 helium Substances 0.000 claims description 4
- 229910052734 helium Inorganic materials 0.000 claims description 4
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 claims description 4
- 229910052786 argon Inorganic materials 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 239000011148 porous material Substances 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 abstract description 12
- 230000008468 bone growth Effects 0.000 abstract description 5
- 238000005192 partition Methods 0.000 abstract description 4
- 230000009286 beneficial effect Effects 0.000 abstract description 3
- 238000002513 implantation Methods 0.000 abstract description 2
- 230000007774 longterm Effects 0.000 abstract description 2
- 238000000465 moulding Methods 0.000 abstract description 2
- 239000011248 coating agent Substances 0.000 description 6
- 238000000576 coating method Methods 0.000 description 6
- 239000002639 bone cement Substances 0.000 description 4
- 238000009826 distribution Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 238000009864 tensile test Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 238000010883 osseointegration Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 2
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- 238000013461 design Methods 0.000 description 2
- 238000001878 scanning electron micrograph Methods 0.000 description 2
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- 230000008467 tissue growth Effects 0.000 description 2
- 229910052719 titanium Inorganic materials 0.000 description 2
- 206010058314 Dysplasia Diseases 0.000 description 1
- 208000007353 Hip Osteoarthritis Diseases 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000003412 degenerative effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 210000001503 joint Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 238000004626 scanning electron microscopy Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/32—Joints for the hip
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30721—Accessories
- A61F2/30734—Modular inserts, sleeves or augments, e.g. placed on proximal part of stem for fixation purposes or wedges for bridging a bone defect
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F5/00—Manufacture of workpieces or articles from metallic powder characterised by the special shape of the product
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y70/00—Materials specially adapted for additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C14/00—Alloys based on titanium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30721—Accessories
- A61F2/30734—Modular inserts, sleeves or augments, e.g. placed on proximal part of stem for fixation purposes or wedges for bridging a bone defect
- A61F2002/30738—Sleeves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2002/30985—Designing or manufacturing processes using three dimensional printing [3DP]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
- A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Manufacturing & Machinery (AREA)
- Materials Engineering (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Vascular Medicine (AREA)
- Mechanical Engineering (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Metallurgy (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses an additive manufacturing titanium alloy zoned bone trabecula artificial hip joint oversleeve and a preparation method thereof, wherein the preparation method comprises the following steps: 1) taking titanium alloy powder as a raw material, obtaining an intermediate product of the additive manufacturing titanium alloy partition trabecular bone artificial hip joint oversleeve through 3D printing and integral forming, and obtaining the additive manufacturing titanium alloy partition trabecular bone artificial hip joint oversleeve through hot isostatic pressing and deep cooling processes; the sleeve structurally comprises a reducing circular tube with a large upper part and a small lower part, the outer surface of the upper part of the reducing circular tube is connected with a lug, and bone trabeculae arranged in a partition mode are arranged on the outer surfaces of the reducing circular tube and the lug; according to the invention, the bone growth area in the bone tissue finite element model accounts for 75%, which is beneficial to bone growth and improves the long-term stability after implantation. The invention adopts 3D printing and integrated molding, has high bonding strength between the trabecula bone and the solid body, is not easy to fall off, and prolongs the service life of the prosthesis. The solid part of the invention releases residual stress and improves the plasticity thereof.
Description
Technical Field
The invention relates to the technical field of artificial joints, in particular to an additive manufacturing titanium alloy zoned bone trabecula artificial hip joint sleeve and a preparation method thereof.
Background
The artificial hip joint replacement operation is one of the most important and effective operations for treating end-stage diseases such as femoral head necrosis, hip joint dysplasia, degenerative hip osteoarthritis, rheumatoid arthritis and the like, and the patients increase year by year with the aggravation of aging population.
The artificial hip joint prosthesis used clinically at present comprises a bone cement fixing type prosthesis and a non-bone cement fixing type prosthesis. Among them, non-bone cement fixed prostheses are increasingly widely used due to their good bone ingrowth properties. The osseointegration interface of the non-bone cement fixed prosthesis usually adopts a hydroxyapatite coating or a titanium coating sprayed on the surface, but the surface coating is easy to fall off, and the use effect is influenced. Therefore, the method for printing the trabecular bone-like porous structure on the combined surface of the bone handle and the host bone tissue can effectively solve the problem that the coating of the coating handle is easy to fall off. Compared with the coated bone handle, the bone handle adopting the trabecular bone structure has the greatest advantages that the bone growth of bone tissues on the surface of the coated bone handle is changed into bone in growth, and the bonding strength of the bone tissues and the trabecular bone at the osseointegration interface is superior to that of the coated bone handle.
At present, the trabecular bone structures on the outer surface of the oversleeve are mostly uniformly distributed, clinical data show that the oversleeve with the uniform trabecular bone structures is adopted, bone tissues are on the upper outer side of the oversleeve, and bone in-growth on the lower inner side and the lower outer side is not ideal. Further studies have shown that the main reasons why bone ingrowth into the upper and lower lateral and medial sides is undesirable are that the contact pressure between the cuff and the bone tissue is small, and the compressive strain values of the bone tissue bonded to the upper and lower lateral sides of the cuff are small, less than 1000 microstrain, and do not satisfy the condition for bone tissue growth, while in the lower lateral region, the contact pressure between the cuff and the bone tissue is too large, and the compressive strain values of the bone tissue bonded to the cuff are large, more than 3000 microstrain, and do not satisfy the condition for bone tissue growth.
The 3D printing technology is used as an additive manufacturing technology, breaks through a product design concept facing a manufacturing process, realizes a product design concept facing performance, solves the problem that complex parts are difficult to integrally form, and reduces waste of raw materials and energy caused by machining and manufacturing. However, the solid part of the 3D printed product is easy to have the problems of uneven microstructure, internal defects and the like, and the mechanical property is poor; the powder in the trabecular bone part structure cannot be well sintered, and the mechanical property is poor. Therefore, the method has important significance for preparing the titanium alloy zoned bone trabecula artificial hip joint sleeve with excellent mechanical property and osseointegration property.
Disclosure of Invention
The invention mainly aims to overcome the defects of the prior art and provide an additive manufacturing titanium alloy zoned bone trabecula artificial hip joint sleeve.
The second purpose of the invention is to provide a preparation method for manufacturing the titanium alloy zoned trabecular artificial hip joint sleeve by additive manufacturing.
The technical scheme of the invention is summarized as follows:
the artificial hip joint sleeve for manufacturing the titanium alloy zoned trabecula bone comprises a reducing circular tube 1 with a large upper part and a small lower part, wherein the outer surface of the upper part of the reducing circular tube 1 is connected with a lug 3, the longitudinal section of the lug 3 passing through the central line is triangular, the cross section of the lug is formed by enclosing the arc of part of the reducing circular tube and a transverse U shape and is arranged in a large upper part and a small lower part, trabecula bone 4 are arranged on the outer surfaces of the reducing circular tube and the lug 3, and the outer surfaces of the reducing circular tube and the lug are divided into an inner upper area 8, an inner lower area 9, an outer upper area 10 and an outer lower area 11 by an axial section 5 of the reducing circular tube vertical to the central line of; the ratio of the height above the cross section 15 of the reducing circular tube to the height below the cross section is 1.5-2.5: 1;
the trabeculae in the medial inferior zone 9 and the lateral superior zone 10 are first trabeculae 12; the trabecular bone in the medial superior region 8 is the second trabecular bone 13; the trabecular bone of the lateral inferior region 11 is a third type of trabecular bone 14;
the aperture and the porosity of the first bone trabecula 12 are smaller than those of the second bone trabecula 13 and the third bone trabecula 14 in sequence.
The aperture of the first bone trabecula is 700-770 μm, and the porosity is 65-75%; the aperture of the second bone trabecula is 780-850 mu m, and the porosity is 76-80%; the aperture of the third trabecular bone is 860-950 μm, and the porosity is 81-85%; the thicknesses of the first bone trabecula 12, the second bone trabecula 13 and the third bone trabecula 14 are equal and are 1.2mm-1.5 mm.
The preparation method of the titanium alloy zoned bone trabecula artificial hip joint sleeve manufactured by additive manufacturing comprises the following steps:
1) taking titanium alloy powder as a raw material, obtaining a first intermediate product for manufacturing the titanium alloy zoned bone trabecula artificial hip joint sleeve through 3D printing and integral forming, putting the first intermediate product into a hot isostatic pressing furnace, heating to 900-950 ℃ under the protection of helium or argon, standing for 1-3 h at a constant temperature under 110-140 MPa, cooling to normal pressure, cooling to below 200 ℃ along with the furnace, and taking out to obtain a second intermediate product:
2) placing the second intermediate product in a programmed cooling box, cooling to-80-120 ℃ at the speed of 1 ℃/min, placing at constant temperature for 5-10 h, and taking out from the programmed cooling box; placing the mixture in liquid nitrogen for 16-36 h, and adjusting the temperature to room temperature to obtain a third intermediate product;
3) placing the third intermediate product in a programmed cooling box, cooling to-80 to-120 ℃ at the speed of 1 ℃/min, and placing for 5 to 10 hours at constant temperature; taking out the box from the programmed cooling box; placing in liquid nitrogen for 16-36 h, and adjusting the temperature to room temperature; obtaining a fourth intermediate product, and performing machining trimming to obtain an additive manufacturing titanium alloy zoned bone trabecula artificial hip joint sleeve;
the first intermediate product, the second intermediate product, the third intermediate product and the fourth intermediate product of the additive manufacturing titanium alloy regional bone trabecula artificial hip joint sleeve are the same as the structure of the additive manufacturing titanium alloy regional bone trabecula artificial hip joint sleeve.
The titanium alloy powder comprises 88-90% of Ti, 5.5-6.5% of Al, 3.5-4.5% of V and the balance of inevitable trace impurities by mass percent; the grain diameter of the titanium alloy powder is 45-106 μm.
The steps 2) and 3) of adjusting the temperature are as follows: heating to-120 to-80 ℃, and keeping the temperature for 3 to 5 hours; heating to-40 to-20 ℃, and keeping the temperature for 3 to 5 hours; heating to 4-8 deg.c, maintaining for 1-3 hr, and heating.
Compared with the prior art, the invention has the following beneficial effects:
the artificial hip joint sleeve for the titanium alloy zoned bone trabecula provided by the invention adopts a zoned bone trabecula mode, and the bone growth area in a bone tissue finite element model accounts for 75 percent, so that the artificial hip joint sleeve is beneficial to bone growth and improves the long-term stability after implantation.
The invention adopts 3D printing and integrated molding, has high bonding strength between the trabecula bone and the solid body, is not easy to fall off, and prolongs the service life of the prosthesis.
The solid part of the titanium alloy zoned trabecular artificial hip joint sleeve is manufactured by additive manufacturing, so that residual stress is released, and the plasticity of the sleeve is improved.
Drawings
FIG. 1 is an axonometric view of an artificial hip cuff for additive manufacturing of titanium alloy zoned trabeculae.
Fig. 2 is a schematic structural view of an artificial hip sleeve made of titanium alloy and having a bone trabecula in a partition area.
FIG. 3 is an axonometric view of an artificial hip cuff for additive manufacturing of a titanium alloy zoned trabecular bone.
Fig. 4 is a cloud of the uniform trabecular artificial hip cuff strain distribution in the control group 1.
Fig. 5 is a cloud graph of the stress distribution of the sleeve of the artificial hip joint of the titanium alloy zoned trabecular bone in example 1.
Fig. 6 is an SEM image of trabecular bone in control group 2.
Fig. 7 is an SEM image of trabeculae of example 1.
FIG. 8 is a metallographic microscopic structure of the solid portion of the uniform trabecular artificial hip cuff of control 2.
Fig. 9 is a metallographic microscopic structure diagram of a solid portion of an additive manufactured titanium alloy zoned trabecular artificial hip cuff of example 1.
Detailed Description
The present invention will be further described with reference to the following examples.
Example 1
The artificial hip joint sleeve (shown in figures 1, 2 and 3) for manufacturing titanium alloy zoned trabeculae comprises a reducing circular tube 1 with a large upper part and a small lower part, wherein the outer surface of the upper part of the reducing circular tube 1 is connected with a lug 3, the longitudinal section of the lug 3 passing through a central line is triangular, the cross section of the lug is formed by enclosing an arc of part of the reducing circular tube and a horizontal U shape and is arranged in a large upper part and a small lower part, trabecular bone 4 is arranged on the outer surfaces of the reducing circular tube and the lug 3, and the outer surfaces of the reducing circular tube and the lug are divided into an inner upper area 8, an inner lower area 9, an outer upper area 10 and an outer lower area 11 by an axial section 5 of the reducing circular tube vertical to the central line; the ratio of the height above the cross section 15 of the reducing circular tube to the height below the cross section is 1.5: 1;
the trabeculae in the medial inferior zone 9 and the lateral superior zone 10 are first trabeculae 12; the trabecular bone in the medial superior region 8 is the second trabecular bone 13; the trabecular bone of the lateral inferior region 11 is a third type of trabecular bone 14;
the aperture of the first bone trabecula is 700 mu m, and the porosity is 65%; the aperture of the second bone trabecula is 780 mu m, and the porosity is 76%; the pore diameter of the third trabecular bone is 860 mu m, and the porosity is 81 percent; the thicknesses of the first bone trabecula 12, the second bone trabecula 13 and the third bone trabecula 14 are equal and are 1.2 mm.
The preparation method of the titanium alloy zoned bone trabecula artificial hip joint sleeve manufactured by additive manufacturing comprises the following steps:
1) taking titanium alloy powder as a raw material, obtaining a first intermediate product for manufacturing the titanium alloy zoned bone trabecula artificial hip joint sleeve through 3D printing and integral forming, putting the first intermediate product into a hot isostatic pressing furnace, heating to 900 ℃ under the protection of helium, standing for 3h at a constant temperature of 140MPa, reducing to normal pressure, cooling to below 200 ℃ along with the furnace, and taking out to obtain a second intermediate product:
2) placing the second intermediate product in a programmed cooling box, cooling to-80 ℃ at the speed of 1 ℃/min, placing at constant temperature for 10h, and taking out from the programmed cooling box; placing in liquid nitrogen for 16h, and adjusting the temperature to room temperature to obtain a third intermediate product;
3) placing the third intermediate product in a programmed cooling box, cooling to-80 ℃ at the speed of 1 ℃/min, and placing for 10h at constant temperature; taking out the box from the programmed cooling box; placing in liquid nitrogen for 16h, and adjusting the temperature to room temperature; obtaining a fourth intermediate product, and performing machining trimming to obtain an additive manufacturing titanium alloy zoned bone trabecula artificial hip joint sleeve;
the first intermediate product, the second intermediate product, the third intermediate product and the fourth intermediate product of the additive manufacturing titanium alloy regional bone trabecula artificial hip joint sleeve are the same as the structure of the additive manufacturing titanium alloy regional bone trabecula artificial hip joint sleeve.
The titanium alloy powder comprises 88 mass percent of Ti, 6.5 mass percent of Al, 4.5 mass percent of V and the balance of inevitable trace impurities; the grain diameter of the titanium alloy powder is 45-106 μm.
The step 2) and the step 3) of adjusting the temperature specifically comprise the following steps: heating to-120 deg.C, and maintaining at constant temperature for 5 hr; then heating to-40 ℃, and keeping the constant temperature for 5 hours; then the temperature is raised to 4 ℃, the temperature is kept for 3 hours at constant temperature, and the temperature is raised.
Example 2
The artificial hip joint sleeve for manufacturing the titanium alloy zoned trabecula bone comprises a reducing circular tube 1 with a large upper part and a small lower part, wherein the outer surface of the upper part of the reducing circular tube 1 is connected with a lug 3, the longitudinal section of the lug 3 passing through the central line is triangular, the cross section of the lug is formed by enclosing the arc of part of the reducing circular tube and a transverse U shape and is arranged in a large upper part and a small lower part, trabecula bone 4 are arranged on the outer surfaces of the reducing circular tube and the lug 3, and the outer surfaces of the reducing circular tube and the lug are divided into an inner upper area 8, an inner lower area 9, an outer upper area 10 and an outer lower area 11 by an axial section 5 of the reducing circular tube vertical to the central line of; the ratio of the height above the cross section 15 of the diameter-variable circular tube to the height below the cross section is 2: 1;
the trabeculae in the medial inferior zone 9 and the lateral superior zone 10 are first trabeculae 12; the trabecular bone in the medial superior region 8 is the second trabecular bone 13; the trabecular bone of the lateral inferior region 11 is a third type of trabecular bone 14;
the aperture of the first bone trabecula is 740 mu m, and the porosity is 70%; the aperture of the second bone trabecula is 810 mu m, and the porosity is 78%; the aperture of the third trabecular bone is 900 mu m, and the porosity is 82%; the thicknesses of the first bone trabecula 12, the second bone trabecula 13 and the third bone trabecula 14 are equal and are 1.3 mm.
The preparation method of the titanium alloy zoned bone trabecula artificial hip joint sleeve manufactured by additive manufacturing comprises the following steps:
1) taking titanium alloy powder as a raw material, obtaining a first intermediate product for manufacturing the titanium alloy zoned bone trabecula artificial hip joint sleeve through 3D printing and integral forming, putting the first intermediate product into a hot isostatic pressing furnace, heating to 930 ℃ under the protection of helium, standing for 2h at a constant temperature of 125MPa, reducing to normal pressure, cooling to below 200 ℃ along with the furnace, and taking out to obtain a second intermediate product:
2) placing the second intermediate product in a programmed cooling box, cooling to-100 ℃ at the speed of 1 ℃/min, placing at constant temperature for 7h, and taking out from the programmed cooling box; placing in liquid nitrogen for 24h again, and adjusting the temperature to room temperature to obtain a third intermediate product;
3) placing the third intermediate product in a programmed cooling box, cooling to-100 ℃ at the speed of 1 ℃/min, and placing for 7h at constant temperature; taking out the box from the programmed cooling box; placing in liquid nitrogen for 24h, and adjusting the temperature to room temperature; obtaining a fourth intermediate product, and performing machining trimming to obtain an additive manufacturing titanium alloy zoned bone trabecula artificial hip joint sleeve;
the first intermediate product, the second intermediate product, the third intermediate product and the fourth intermediate product for the additive manufacturing of the titanium alloy zoned bone trabecular artificial hip joint sleeve have the same structure as the additive manufacturing of the titanium alloy zoned bone trabecular artificial hip joint sleeve.
The titanium alloy powder comprises 89% of Ti, 6% of Al, 4% of V and the balance of inevitable trace impurities by mass percent; the grain diameter of the titanium alloy powder is 45-106 μm.
The steps 2) and 3) of adjusting the temperature are as follows: heating to-100 deg.C, and maintaining at constant temperature for 4 hr; heating to-30 deg.C, and maintaining at constant temperature for 4 hr; the temperature is raised to 6 ℃, the temperature is kept for 2 hours at constant temperature, and the temperature is raised.
Example 3
The artificial hip joint sleeve for manufacturing the titanium alloy zoned trabecula bone comprises a reducing circular tube 1 with a large upper part and a small lower part, wherein the outer surface of the upper part of the reducing circular tube 1 is connected with a lug 3, the longitudinal section of the lug 3 passing through the central line is triangular, the cross section of the lug is formed by enclosing the arc of part of the reducing circular tube and a transverse U shape and is arranged in a large upper part and a small lower part, trabecula bone 4 are arranged on the outer surfaces of the reducing circular tube and the lug 3, and the outer surfaces of the reducing circular tube and the lug are divided into an inner upper area 8, an inner lower area 9, an outer upper area 10 and an outer lower area 11 by an axial section 5 of the reducing circular tube vertical to the central line of; the ratio of the height above the cross section 15 of the reducing circular tube to the height below the cross section is 2.5: 1;
the trabeculae in the medial inferior zone 9 and the lateral superior zone 10 are first trabeculae 12; the trabecular bone in the medial superior region 8 is the second trabecular bone 13; the trabecular bone of the lateral inferior region 11 is a third type of trabecular bone 14;
the aperture of the first bone trabecula is 770 microns, and the porosity is 75%; the aperture of the second bone trabecula is 850 mu m, and the porosity is 80%; the aperture of the third trabecular bone is 950 mu m, and the porosity is 85 percent; the thicknesses of the first bone trabecula 12, the second bone trabecula 13 and the third bone trabecula 14 are equal and are 1.5 mm.
The preparation method of the titanium alloy zoned bone trabecula artificial hip joint sleeve manufactured by additive manufacturing comprises the following steps:
1) taking titanium alloy powder as a raw material, obtaining a first intermediate product for manufacturing the titanium alloy zoned bone trabecula artificial hip joint sleeve through 3D printing and integral forming, putting the first intermediate product into a hot isostatic pressing furnace, heating to 950 ℃ under the protection of argon, standing for 1h at a constant temperature of 110MPa, reducing to normal pressure, cooling to below 200 ℃ along with the furnace, and taking out to obtain a second intermediate product:
2) placing the second intermediate product in a programmed cooling box, cooling to-120 ℃ at the speed of 1 ℃/min, placing at constant temperature for 5h, and taking out from the programmed cooling box; placing in liquid nitrogen for 36h, and adjusting the temperature to room temperature to obtain a third intermediate product;
3) placing the third intermediate product in a programmed cooling box, cooling to-120 ℃ at the speed of 1 ℃/min, and placing for 5h at constant temperature; taking out the box from the programmed cooling box; placing in liquid nitrogen for 36h, and adjusting the temperature to room temperature; obtaining a fourth intermediate product, and performing machining trimming to obtain an additive manufacturing titanium alloy zoned bone trabecula artificial hip joint sleeve;
the first intermediate product, the second intermediate product, the third intermediate product and the fourth intermediate product for the additive manufacturing of the titanium alloy zoned bone trabecular artificial hip joint sleeve have the same structure as the additive manufacturing of the titanium alloy zoned bone trabecular artificial hip joint sleeve.
The titanium alloy powder comprises 90% of Ti, 5.5% of Al, 3.5% of V and the balance of inevitable trace impurities by mass percent; the grain diameter of the titanium alloy powder is 45-106 μm.
The steps 2) and 3) of adjusting the temperature are as follows: heating to-80 deg.C, and maintaining at constant temperature for 3 hr; heating to-20 deg.C, and maintaining at constant temperature for 3 hr; heating to 8 deg.C, maintaining at constant temperature for 1h, and heating.
Control group 1
The difference between the preparation method and the structure of the uniform trabecular bone artificial hip sleeve and the embodiment 1 is that the first, the second and the third trabecular bone are the same trabecular bone, the aperture is 780 mu m, the porosity is 76 percent and the thickness of the trabecular bone is 1.2 mm.
Control group 2
Titanium alloy powder (same as example 1) is used as a raw material, and the artificial hip joint sleeve with the structure same as that of example 1 is obtained through 3D printing and integrated forming and machining finishing.
Experimental verification
Finite element analysis is carried out on the finite element model in the embodiment 1 and the finite element model in the control group 1, the obtained strain distribution cloud chart only shows the micro strain (shaded part) with the range of 1000-3000, the proportion of the 1000-3000 micro strain area on the bone tissue finite element model in the whole bone tissue finite element model in the embodiment 1 is 75 percent (figure 5) and is more than that of the control group 1 (figure 4, and the proportion of the 1000-3000 micro strain area is 30 percent), and the method for manufacturing the titanium alloy zoned trabecular artificial hip cuff by the additive material can realize that the micro strain of most areas of the bone tissue is between the lowest effective strain threshold and the supraphysiological strain threshold, so that the bone ingrowth is facilitated.
Finite element analysis results prove that the strain distribution cloud charts of the additive manufacturing titanium alloy zoned trabecular artificial hip sleeve of the embodiments 2 and 3 are similar to those of the additive manufacturing titanium alloy zoned trabecular artificial hip sleeve of the embodiment 1.
The trabecular bone parts of control 2 and example 1 were analyzed for observation by scanning electron microscopy (Crossbeam340/550, zeiss, germany). As shown in fig. 6 to 7, the titanium alloy powder in the trabecular bone structure of example 1 was further sintered compared to the control group 2, indicating that the overall performance of the trabecular bone part of the artificial hip cuff for additive manufacturing of the titanium alloy zoned trabecular bone according to the present invention was improved.
Metallographic microstructure observation was performed on the solid portions of control 2 and example 1. As a result, as shown in fig. 8 to 9, the α phase was shortened, the α bundle domain size was smaller, and the original β crystal grains were destroyed in example 1 as compared with control 2, suggesting that the solid portion of the titanium alloy zoned trabecular artificial hip cuff of the present invention is plastically strengthened.
The tensile properties of the physical tensile test pieces of example 1 and control 2 were tested in an electronic universal tester (UTM5105, Shenzhen Sansi technologies, Inc., China) in accordance with the standard GB/T228.1-2010, with 5 physical tensile test pieces of example 1 and control 2 each. As shown in Table 1, the tensile strength of example 1 was 1006.73MPa, which is close to that of control 2(P > 0.05); the elongation after fracture of example 1 is 18.83%, which is higher than that of the control group 2(P < 0.01), and the solid part of the sleeve for the titanium alloy zoned trabecular artificial hip joint manufactured by the additive manufacturing method is excellent in plasticity.
Table 1 tensile test results of the solid tensile test pieces of control group 2 and example 1: (
n is 5, P is less than 0.01, compare with control 2)
The trabecular bone shear specimens of control 2 and example 1, which had a pore diameter of 780 μm and a porosity of 76%, were subjected to shear performance testing in accordance with standard YY/T0988.12-2015, electronic universal testing machine (UTM5105, shenzhen mitsui longitudinal and transverse science and technology ltd., china), and 5 trabecular bone shear specimens of control 2 and example 1, respectively. As shown in Table 2, the average shear strength of the control group 2 is 35.94MPa, the average shear strength of the example 1 is 49.12MPa, which is significantly higher than that of the control group 2 and is 1.37 times that of the control group 2, and there is a statistical difference (P < 0.01), which indicates that the shear strength of the trabecular bone in the example 1 is enhanced and is 2.46 times that of the coating shear strength (shear strength 20MPa) in YY 0502-2016, and the shear strength of the trabecular bone sleeve of the titanium alloy zoned trabecular artificial hip joint sleeve of the invention is high.
Table 2 shear test results of trabecular bone shear test pieces of control group 2 and example 1: (
P < 0.01, compared to control 2)
Experiments prove that the additive manufacturing titanium alloy zoned bone trabecular artificial hip joint oversleeve prepared in the embodiments 2 and 3 has similar sintering degree, shearing strength and solid part metallographic structure and tensile property with the additive manufacturing titanium alloy zoned bone trabecular artificial hip joint oversleeve prepared in the embodiment 1.
Claims (5)
1. The artificial hip joint sleeve for the titanium alloy zoned trabecula bone comprises a reducing circular tube (1) with a large upper part and a small lower part, wherein the outer surface of the upper part of the reducing circular tube (1) is connected with a lug (3), the longitudinal section of the lug (3) passing through a central line is triangular, the cross section of the lug is formed by enclosing an arc of part of the reducing circular tube and a horizontal U shape and is arranged in a large lower part, and the artificial hip joint sleeve is characterized in that the bone trabecula (4) is arranged on the outer surfaces of the reducing circular tube and the lug (3), and the outer surfaces of the reducing circular tube and the lug are divided into an inner upper area (8), an inner lower area (9), an outer upper area (10) and an outer lower area (11) by an axial section (5) of the reducing circular tube perpendicular to the; the ratio of the height above the cross section (15) of the reducing circular tube to the height below is 1.5-2.5: 1; the trabeculae of the medial inferior region (9) and the lateral superior region (10) are first trabeculae (12); the trabecular bone of the medial superior region (8) is a second trabecular bone (13); the trabecula of the lateral inferior region (11) is a third trabecula (14); the aperture and the porosity of the first bone trabecula (12) are smaller than those of the second bone trabecula (13) and the third bone trabecula (14) in sequence.
2. The additive manufactured titanium alloy zoned trabecular bone artificial hip sleeve according to claim 1, wherein the first trabecular bone has a pore size of 700-770 μm and a porosity of 65-75%; the aperture of the second bone trabecula is 780-850 mu m, and the porosity is 76-80%; the aperture of the third trabecular bone is 860-950 μm, and the porosity is 81-85%; the thicknesses of the first bone trabecula (12), the second bone trabecula (13) and the third bone trabecula (14) are equal and are 1.2mm-1.5 mm.
3. The method for preparing the titanium alloy zoned trabecular artificial hip sleeve according to claim 1 or 2, characterized by comprising the following steps:
1) taking titanium alloy powder as a raw material, obtaining a first intermediate product for manufacturing the titanium alloy zoned bone trabecula artificial hip joint sleeve through 3D printing and integral forming, putting the first intermediate product into a hot isostatic pressing furnace, heating to 900-950 ℃ under the protection of helium or argon, standing for 1-3 h at a constant temperature under 110-140 MPa, cooling to normal pressure, cooling to below 200 ℃ along with the furnace, and taking out to obtain a second intermediate product:
2) placing the second intermediate product in a programmed cooling box, cooling to-80-120 ℃ at the speed of 1 ℃/min, placing at constant temperature for 5-10 h, and taking out from the programmed cooling box; placing the mixture in liquid nitrogen for 16-36 h, and adjusting the temperature to room temperature to obtain a third intermediate product;
3) placing the third intermediate product in a programmed cooling box, cooling to-80 to-120 ℃ at the speed of 1 ℃/min, and placing for 5 to 10 hours at constant temperature; taking out the box from the programmed cooling box; placing in liquid nitrogen for 16-36 h, and adjusting the temperature to room temperature; obtaining a fourth intermediate product, and performing machining trimming to obtain an additive manufacturing titanium alloy zoned bone trabecula artificial hip joint sleeve;
the first intermediate product, the second intermediate product, the third intermediate product and the fourth intermediate product of the additive manufacturing titanium alloy regional bone trabecula artificial hip joint sleeve are the same as the structure of the additive manufacturing titanium alloy regional bone trabecula artificial hip joint sleeve.
4. The method as claimed in claim 3, wherein the titanium alloy powder has chemical compositions, by mass, comprising 88 to 90% of Ti, 5.5 to 6.5% of Al, 3.5 to 4.5% of V, and the balance unavoidable trace impurities; the grain diameter of the titanium alloy powder is 45-106 μm.
5. The method of claim 3, wherein the steps 2) and 3) of adjusting the temperature are: heating to-120 to-80 ℃, and keeping the temperature for 3 to 5 hours; heating to-40 to-20 ℃, and keeping the temperature for 3 to 5 hours; heating to 4-8 deg.c, maintaining for 1-3 hr, and heating.
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| WO2022206820A1 (en) * | 2021-04-01 | 2022-10-06 | 北京市春立正达医疗器械股份有限公司 | Trabecular bone bionic member and implant |
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| WO2022206820A1 (en) * | 2021-04-01 | 2022-10-06 | 北京市春立正达医疗器械股份有限公司 | Trabecular bone bionic member and implant |
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