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CN112137626B - A multi-channel detection device - Google Patents

A multi-channel detection device Download PDF

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Publication number
CN112137626B
CN112137626B CN202010857479.6A CN202010857479A CN112137626B CN 112137626 B CN112137626 B CN 112137626B CN 202010857479 A CN202010857479 A CN 202010857479A CN 112137626 B CN112137626 B CN 112137626B
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sensor
motor
reagent
detection
module
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CN112137626A (en
Inventor
马千理
丁建林
周健敏
张文伶
杨清刚
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Hangzhou Weice Biotechnology Co ltd
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Hangzhou Weice Biotechnology Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1486Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
    • A61B5/14865Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1495Calibrating or testing of in-vivo probes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Optics & Photonics (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

本发明公开了一种多通道检测装置,包括传感器模块,传感器模块包括固定机构,固定机构包括传感器放置板、传感器压板、动力装置,传感器放置板与传感器压板连接,传感器压板与动力装置连接,传感器压板在动力装置的驱动下,能够压紧传感器放置板,固定传感器。本发明的多通道检测装置能够实现多通道同时检测;而且能够使得传感器在动态环境中完成检测,相对于静止检测,本发明中的动态环境更接近于人体中的环境,检测的结果较为准确,重复检测时误差较小,有利于检测与评估传感器的性能。本发明的检测装置能够检测传感器的多种性能,比如灵敏度、使用寿命、力学性能、重复精度、耐蚀性。

The present invention discloses a multi-channel detection device, including a sensor module, the sensor module including a fixing mechanism, the fixing mechanism including a sensor placement plate, a sensor pressure plate, and a power device, the sensor placement plate is connected to the sensor pressure plate, the sensor pressure plate is connected to the power device, and the sensor pressure plate, driven by the power device, can press the sensor placement plate to fix the sensor. The multi-channel detection device of the present invention can realize multi-channel simultaneous detection; and can enable the sensor to complete detection in a dynamic environment. Compared with static detection, the dynamic environment in the present invention is closer to the environment in the human body, the detection result is more accurate, and the error is small during repeated detection, which is conducive to detecting and evaluating the performance of the sensor. The detection device of the present invention can detect various performances of the sensor, such as sensitivity, service life, mechanical properties, repeatability, and corrosion resistance.

Description

Multichannel detection device
Technical Field
The invention particularly relates to a multichannel detection device.
Background
The dynamic blood glucose monitor (CGMS) is one of diagnosis and treatment instruments of endocrinology, and is used for collecting blood glucose dynamic change data of diabetics for a plurality of days and making a monitoring tool of blood glucose maps. Through the instrument, doctors can comprehensively know the blood sugar fluctuation type and trend of patients, and the instrument has great significance for blood sugar control and diabetes treatment. The dynamic blood sugar detector consists of a glucose emitter and a blood sugar recorder, wherein the emitter is internally provided with a subcutaneous implantable sensor, and the dynamic blood sugar detector has the characteristics of strong detection function, small volume, convenient use, small pain and the like, and can accurately grasp the blood sugar condition of patients with abnormal blood sugar and complicated illness. The glucose oxidase contained on the subcutaneous sensor reacts with the glucose in the subcutaneous tissue fluid, and the generated electric signal is transmitted by the sensor to analysis software through a transmitter and then converted into a blood glucose value.
Because the sensor needs to be implanted into a human body, the period of contacting the human body is long (about 20 days); this requires a longer service life for the sensor; some patients have rejection and pain to the sensor, which requires the sensor to have better biocompatibility and mechanical properties; in addition, the sensitivity of the sensor to react with substances in the human body, the repeatability precision of the sensor, corrosion resistance and other performances are also important. Therefore, it is necessary to detect the performance of the sensor.
Currently, most devices for detecting sensor performance have limited sensor parameters that can be detected, and have a long detection period; only the final data result is displayed, and the tracking data is not detected in real time; detection of the analog sensor in the human body cannot be truly performed; the detection parameters cannot be output alone, and data compatible with the third party data cannot be derived; the research personnel can only judge the acceptable degree of the data result according to experience.
Disclosure of Invention
In view of the foregoing, in order to overcome the defects in the prior art, the present invention provides a multi-channel detection device.
In order to achieve the above object, the present invention provides the following technical solutions:
The utility model provides a multichannel detection device, includes the sensor module, the sensor module includes fixed establishment, fixed establishment is including being used for placing the sensor place the board, be used for fixed sensor's sensor clamp plate, provide power device, the sensor is placed the board and is connected with the sensor clamp plate, the sensor clamp plate is directly or indirectly connected with power device, the sensor clamp plate is under power device's drive, can compress tightly the sensor and place the board, fixed sensor.
Further, the power device is a motor, and the motor is connected with the sensor pressing plate. Other existing devices capable of providing power, such as external combustion engines, internal combustion engines, ion engines, etc., may also be employed as the power device.
Further, the motor drives the sensor pressing plate to rotate through the synchronous belt and the synchronous wheel, and the synchronous wheel comprises a first synchronous wheel and a second synchronous wheel.
Further, the motor is connected with a first synchronous wheel, the first synchronous wheel is connected with a synchronous belt, the synchronous belt is connected with a second synchronous wheel, the second synchronous wheel is connected with a second shaft, and the sensor pressing plate is also connected with the second shaft.
Further, the sensor placing plate surface is provided with a slot, which can be used for placing a sensor.
Further, the open end of the slot is provided with a locating surface.
Further, the lower surface of the sensor pressing plate is provided with a bump which can be clamped at the lower part of the slot.
Further, the sensor pressing plate is connected with the sensor placing plate through a hinge.
Further, a sensor circuit board is connected to the sensor pressing plate.
Further, the sensor module further comprises a height adjusting device, the height adjusting device comprises a motor for providing driving force, a power transmission device for transmitting power, and a mounting plate for directly or indirectly mounting the sensor placement plate, the power device is connected with the power transmission device, the mounting plate is connected with the power transmission device, the power transmission device comprises a screw rod, the screw rod rotates under the driving of the power device, and the mounting plate and the sensor can move upwards or downwards.
Further, the power transmission device further comprises a coupler, and the coupler is connected with the power device and the screw rod respectively.
Further, the power transmission device further comprises a screw rod sleeve, and the screw rod sleeve is connected with the mounting plate.
Further, the height adjustment device also comprises a limiting component. The limiting assembly comprises a polish rod, a polish rod sleeve and a supporting seat, wherein the polish rod is connected with the polish rod sleeve, and the polish rod sleeve is connected with the mounting plate.
Further, the detection device further comprises a reagent module, the reagent module comprises a reagent containing device and a vortex generating device, the reagent containing device is connected with the vortex generating device, the reagent containing device comprises a reagent box, the vortex generating device comprises a motor, a gear and a tray, the motor is connected with the tray, the motor is further connected with the gear, the gear is further connected with the reagent box, the motor drives the gear to rotate, the reagent box rotates, vortex is generated in the reagent box, the reagent is uniformly mixed, the vortex detection is convenient to carry out, and the mechanical property and the repeated precision of the detection sensor are convenient to detect.
In some preferred modes, the gears comprise a first gear and a second gear, the first gear is in meshed connection with the second gear, the first gear is respectively connected with the tray and the kit, and the second gear is connected with the motor. The motor drives the second gear and the first gear to rotate, the kit rotates, and vortex is generated in the kit.
In other preferred forms, the gear comprises a second gear, the second gear being coupled to the motor, the second gear also being coupled to the kit.
Further, the kit comprises a groove for containing the reagent, wherein the groove is an annular groove, and the centers of the annular grooves are identical.
The beneficial effects of the invention are as follows:
(1) The multi-channel detection device can realize multi-channel simultaneous detection; and the sensor can complete detection in a dynamic environment, compared with static detection, the dynamic environment in the invention is closer to the environment in a human body, the detection result is more accurate, the error is smaller when the detection is repeated, and the detection and the evaluation of the performance of the sensor are facilitated.
(2) The detection device provided by the invention can detect various performance parameters of the sensor, such as sensitivity, service life, mechanical property, repetition accuracy and corrosion resistance.
(3) According to the invention, the state of the sensor in the human body is simulated through the modularized, automatic and intelligent sensor detection device, so that the detection precision, efficiency and range are improved; the humanized functions of intelligent identification, module type selection, dynamic detection, performance improvement and the like are realized.
(4) The detection device can be used for detecting a plurality of sensors simultaneously and detecting solutions with different concentrations and different components.
(5) The detection device can realize intelligent interaction and remote dynamic detection, and is applicable to sensors with different specifications; moreover, the detection device provided by the invention can be used for obtaining a final detection result and also obtaining real-time detection data.
(6) The detection device is convenient for loading and unloading the sensor, can be connected with third party data, and is easy to realize automation and integration.
(7) In the invention, the surface of the sensor placing plate is provided with a plurality of slots, so that a plurality of sensors can be placed conveniently, and batch placement of the sensors and batch detection are facilitated. The open end of slot is provided with the locating surface, is convenient for put into the slot with the sensor, and in putting into the slot with the sensor, the locating surface can be fixed the upper segment of sensor moreover, avoids the sensor slope or breaks away from the slot.
(8) The fixing mechanism has high degree of automation, flexible and stable operation, and can automatically adjust the included angle between the sensor placing plate and the sensor pressing plate (the included angle between the sensor placing plate and the sensor pressing plate is 0-90 degrees), so as to fix the sensor or release the fixation; when the included angle between the sensor placing plate and the sensor pressing plate is 0 degree, the sensor pressing plate compresses the sensor, and the sensor is fixed, so that the sensor is prevented from falling off the sensor placing plate; when the contained angle between the sensor placing plate and the sensor pressing plate is 90 degrees, the sensor placing plate is convenient to place and install the sensor on the sensor placing plate, and the sensor is convenient to detach from the sensor placing plate.
Drawings
FIG. 1 is a schematic diagram of the structure of the detecting device of the present invention.
FIG. 2 is a schematic view of the structure of the back of the detecting unit of the present invention.
Fig. 3 is a schematic diagram of the data transmission relationship between the modules.
Fig. 4 is a schematic diagram of the structure of the transmission module.
Fig. 5 is a schematic diagram of a wireless transmitter installation.
Fig. 6 is a schematic diagram of a wireless transmission circuit board mounted on a sensor platen, wherein (a) is a schematic diagram of a back structure of the sensor platen, and (b) is a schematic diagram of a front structure of the sensor platen.
Fig. 7 is a schematic structural diagram of an interaction module, where (a) is a schematic structural diagram of a front surface of a touch screen, and (b) is a schematic structural diagram of a back surface of the touch screen.
Fig. 8 is a schematic diagram of a data transmission relationship between an interactive module and other modules.
Fig. 9 is a schematic diagram of the wiring connection between the interactive module and the other modules.
Fig. 10 is a schematic structural view of a sensor module.
Fig. 11 is a schematic diagram of the structure of the sensor module side (showing the timing belt and timing wheel).
Fig. 12 is a schematic view of a mounting structure of the spring contact.
Fig. 13 is a cross-sectional view of fig. 12.
FIG. 14 is a schematic diagram of the connection of a sensor placement plate to a sensor platen.
Fig. 15 is an exploded view of the securing mechanism.
Fig. 16 is an exploded view of the height adjustment device.
Fig. 17 is a schematic view of the installation of the sensor module, in which (a) is a schematic view of the structure of the back surface of the detection device after the installation of the sensor module, and (b) is a schematic view of the structure of the side surface of the detection device after the installation of the sensor module.
Fig. 18 is a schematic view of the height adjusting apparatus when the first motor is operated.
Fig. 19 is a schematic structural view of the fixing mechanism when the second motor is operated.
Fig. 20 is a schematic view of the structure of the fixing mechanism when the angle between the sensor pressing plate and the sensor placing plate is 90 degrees.
Fig. 21 is a schematic view of the structure of the fixing mechanism when the angle between the sensor pressing plate and the sensor placing plate is 70 degrees.
Fig. 22 is a schematic view of the structure of the fixing mechanism when the angle between the sensor pressing plate and the sensor placing plate is 0 degrees.
Fig. 23 is a schematic structural view of the sensor module when the angle between the sensor platen and the sensor placement plate is 0 degrees.
FIG. 24 is a schematic diagram of the structure of a reagent module.
FIG. 25 is a schematic illustration of a reagent module installation.
Fig. 26 is a schematic structural view of the power supply module.
Fig. 27 is a schematic structural view of the control module.
Fig. 28 is a schematic structural view of the driving module.
Fig. 29 is a schematic structural view of the frame module.
FIG. 30 is an exploded view of the detection device of the present invention.
Fig. 31 is a schematic diagram of a sensor detection process.
FIG. 32 is a schematic diagram of a reagent detection process.
FIG. 33 is a schematic view of the touch screen display during sensor detection.
Fig. 34 is a schematic view of the touch screen display content (showing the detection result) during the detection process of the sensor.
Fig. 35 is a schematic diagram of a sensor structure, in which (a) is a schematic diagram of a single sensor structure, and (b) is a schematic diagram of a structure in which a plurality of sensors are connected in parallel.
Fig. 36 is a schematic structural view of the sensor-mounting board, in which (a) is a schematic side structural view of the sensor-mounting board and (b) is a schematic front structural view of the sensor-mounting board.
FIG. 37 is a schematic diagram of a square kit; wherein (a) is a cross-sectional view of the square kit, and (b) is a top view of the square kit.
Fig. 38 is a schematic structural view of a circular kit, wherein (a) is a sectional view of the kit and (b) is a schematic structural view of the interior of the kit.
Fig. 39 is a schematic diagram of the connection relationship between the sensor and the sensor-mounting board, wherein (a) is a schematic diagram of the structure in which the sensor and the sensor-mounting board are separated from each other, and (b) is a schematic diagram of the structure in which the sensor and the sensor-mounting board are combined.
FIG. 40 is a schematic illustration of the connection of the kit to the first gear.
FIG. 41 is a schematic diagram of the structure of the device of the present invention prior to detecting sensor performance.
FIG. 42 is a schematic view of the structure of the detecting device according to the present invention when the angle between the sensor platen and the sensor mounting plate is 0 degrees.
FIG. 43 is a schematic view showing the structure of the detecting device of the present invention when the position of the kit is adjusted.
FIG. 44 is a schematic diagram showing the structure of the detecting device of the present invention during insertion of a sensor into a reagent.
FIG. 45 is a schematic view of the detection device of the present invention in stationary detection.
FIG. 46 is a schematic diagram of the detection device of the present invention in vibration detection.
Fig. 47 is a schematic diagram of the structure of the detection device of the present invention in vortex detection.
FIG. 48 is a schematic diagram of the detection apparatus according to the present invention in the case of a composite detection.
FIG. 49 is a schematic view of another implementation of a reagent position adjustment device.
FIG. 50 is a schematic view of another implementation of the reagent position adjusting apparatus (showing the relative positional relationship between gears, motors, conveyor belts, slides).
Fig. 51 is a side view of fig. 49.
Detailed Description
The following further details the technical solution of the present invention with reference to the accompanying drawings, it should be noted that the detailed description is only of the present invention and should not be taken as limiting the invention. The motor described below is mainly used for providing power, and other devices capable of providing power can be applied to the present invention, and the present invention is not limited to the devices for providing power.
Example 1
As shown in fig. 1-2, a multi-channel detection device comprises a transmission module 1, an interaction module 2, a sensor module 3, a reagent module 4, a power supply module 5, a control module 6, a driving module 7 and a frame module 8. The transmission module 1, the interaction module 2, the sensor module 3, the reagent module 4, the power supply module 5, the control module 6 and the driving module 7 are respectively connected with the frame module 8.
In some preferred ways, as shown in fig. 3, the transmission module 1 can identify the signals from the sensor module 3 and the reagent module 4, and can feed back the signals to the control module 6, the control module 6 can transmit the signals to the interaction module 2, the interaction module 2 can display corresponding data, the control module 6 can also receive the signals from the interaction module 2, the control module 6 can control the driving module 7 to move, and the power supply module 5 can supply power to the whole device. The transmission module 3 is also capable of transmitting data to the outside or receiving data from the outside.
In some preferred forms, as shown in fig. 29, the frame module 8 is composed of a left side panel 39, a right side panel 40, a rear panel 41, a top panel 42, a partition 43, and a bottom panel 222, with the final assembly effect shown in fig. 1.
In some preferred forms, as shown in fig. 10-11, the sensor module 3 includes a fixing mechanism for mounting and fixing the sensor, a height adjustment device for adjusting the vertical distance between the sensor and the detection reagent, and a collection device for collecting the sensor signal.
In some preferred forms, as shown in fig. 10-11, the height adjustment device includes a first motor 121, a first coupling 123, a first screw 124, and a mounting plate 128, where the first motor 121 is coupled to the first coupling 123, the first coupling 123 is coupled to the first screw 124, and the first screw 124 is directly or indirectly coupled to the mounting plate 128, where the sensor placement plate may be directly or indirectly coupled thereto. The first motor 121 can provide power, and the first coupler 123 connects the first motor 121 with the first screw rod 124 to transmit motion and power. If the first motor 121 is activated, the first screw 124 can be rotated therewith. In other embodiments, instead of the first screw 124, a gear may be used in combination with a toothed plate to adjust the height of the sensor. In some preferred forms, the first motor 121 can drive the first screw 124 to move clockwise or counterclockwise; the programmable electric pulse signal is input to the motor so that the first motor 121 has two motion modes of uniform speed and variable speed. The motor used in the invention can adopt the motor and the coupling in the prior art, and the invention does not improve the structure and the working principle of the motor and the coupling.
In some preferred forms, as shown in fig. 10-11, the height adjustment device further includes a first motor bracket 120, the first motor 121 can be mounted on the first motor bracket 120, and the first motor bracket 120 can be fixed on the frame module 8, thereby enabling the fixation of the first motor 121.
In some preferred forms, as shown in fig. 10-11, the height adjustment device further includes a first screw sleeve 127, the first screw sleeve 127 being mated with the first screw 124, the first screw sleeve 127 being capable of being mounted on other components, in this embodiment, the first screw sleeve 127 being mounted on a mounting plate 128; the first screw rod 124 can rotate within the first screw rod sleeve 127, and when the first screw rod 124 rotates, the first screw rod sleeve 127 can move linearly along the first screw rod 124, and the mounting plate 128 can move linearly along with the first screw rod 124 (e.g., the first screw rod sleeve 127 and the mounting plate 128 can move downward or upward along the first screw rod 124, and the first screw rod 124 moves clockwise or counterclockwise to determine whether the first screw rod sleeve 127 and the mounting plate 128 move upward or downward).
In some preferred forms, as shown in fig. 10-11, the height adjustment device further includes a limit assembly that limits the maximum distance the mounting plate 128 can move up or down, preventing the mounting plate 128 from moving up too far, contact wear to the first coupling 123, and also preventing the mounting plate 128 from moving down too far, out of the first lead screw 124.
In some preferred embodiments, as shown in fig. 10, the limiting assembly includes a polish rod 125, a polish rod sleeve 126 and a support base 122, where the polish rod 125 is sleeved with the polish rod sleeve 126, and the support base 122 is connected with the polish rod 125, in this embodiment, as shown in fig. 16, the polish rod 125 can be inserted into the polish rod sleeve 126 and can be inserted into an opening on the support base 122 to a step surface, and then the polish rod 125 and the support base 122 are locked by using a set screw 111, so that the polish rod 125 is fixedly connected with the support base 122. In some preferred forms, as shown in fig. 10-11, the polish rod cover 126 is mounted and secured to the mounting plate 128, and two support bases 122 are attached to the ends of the polish rod 125, above and below the mounting plate 128, respectively, the upper support base 122 being capable of defining the mounting plate 128 such that the mounting plate 128 cannot move upward without restriction, and likewise the lower support base 122 such that the mounting plate 128 cannot move downward without restriction. In some preferred ways, as shown in fig. 17, the support base 122 may be mounted and secured to the frame module 8 by set screws 111. In this embodiment, the shaft coupling can flexibly compensate the installation error of motor and lead screw, avoids power device and lead screw to cause motion card to be blocked because of installation error, avoids power device to cause the burning out because of the torque imbalance.
The motor 121 is started to drive the first coupling 123 to rotate, the first coupling 123 drives the first screw rod 124 to rotate, so that the first screw rod sleeve 127 and the mounting plate 128 can do upward or downward linear reciprocating motion, the supporting seats 122 at two ends of the polished rod 125 are mechanically limited, (the number of rotations of the motor is defined in the control module as software limiting, the number of rotations of the motor is limited, the number of rotations of the first coupling is controlled to be converted into a linear length, and the general software limiting distance is less than or equal to the mechanical limiting distance), and in some preferred modes, the movement range of the mounting plate is 0-25 mm. In some preferred forms, the motor 121 is a stepper motor and the first screw 124 and the first screw sleeve 127 are ball screws. The stepping motor can realize accurate control according to constant rotation characteristics of the stepping angle; the ball screw can realize higher displacement precision and transmission efficiency, extremely low shaking coefficient and friction resistance and higher repeated positioning precision during reciprocating movement. The ball screw used in the invention is available commercially, and the invention does not improve the structure and the working principle of the ball screw.
In some preferred forms, the securing mechanism includes a sensor placement plate 134, a sensor platen 135, the sensor placement plate 134 being capable of being used to mount and place the sensor 133, the sensor platen 135 being capable of being used to secure the compression sensor 133, the sensor placement plate 134 being connected to the sensor platen 135, in some preferred forms, the sensor placement plate 134 being connected to the sensor platen 135 by a connecting shaft, similar to a hinge type connection. In this embodiment, as shown in fig. 14, the convex portion of the sensor placing plate 134 is fitted into the concave portion of the sensor pressing plate 135 in the 1 direction, and then the third shaft 141 is inserted into the shaft hole in the 2 direction, so that the sensor placing plate 134 is coupled with the sensor pressing plate 135, and the sensor placing plate 134 can hinge along the third shaft 141 in the range of 0 to 90 degrees. The included angle between the sensor placing plate 134 and the sensor pressing plate 135 may be 0-90 degrees, when the included angle between the sensor placing plate 134 and the sensor pressing plate 135 is 0 degrees, as shown in fig. 23, the sensor pressing plate 135 compresses the sensor 133 on the sensor placing plate 134, and fixes the sensor 133, so that the sensor 133 is prevented from loosening and falling from the sensor placing plate 134; when the angle between the sensor placing plate 134 and the sensor pressing plate 135 is 90 degrees, as shown in fig. 10, the sensor 133 is conveniently placed and mounted on the sensor placing plate 134, and the sensor 133 is also conveniently detached from the sensor placing plate 134.
In some preferred forms, the sensor platen 135 is coupled to the mounting plate 128, and in some preferred forms, the sensor platen 135 is hingedly coupled to the mounting plate 128 via a connecting shaft, similar to a hinge type connection. In this embodiment, as shown in fig. 15, the convex portion of the sensor pressing plate 135 is fitted into the concave portion of the mounting plate 128, and then the second shaft 137 is inserted into the shaft hole, so that the mounting plate 128 is connected to the sensor pressing plate 135, and the sensor pressing plate 135 can be rotated about the second shaft 137 with respect to the mounting plate 128. When the mounting plate 128 moves up or down along the first screw 124, the sensor platen 135 and the sensor placement plate 134 can both move up or down with it, thus changing the height of the sensor and the distance of the sensor from the reagent.
In some preferred forms, the sensor placement plate 134 is fixedly mounted or indirectly coupled to the mounting plate 128, and in this embodiment, as shown in FIGS. 10 and 15, the two are coupled together by a linkage 136, one end of the linkage 136 being coupled to the sensor placement plate 134 and the other end being coupled to the mounting plate 128. The protruding head at the end of the connecting rod 136 can be inserted into the groove on the mounting plate 128 to realize clamping, and the protruding head at the end of the connecting rod 136 can rotate in the groove without falling out. Likewise, the projection of the other end portion of the link 136 can be connected to the groove provided on the sensor placing plate 134, and the projection can also rotate in the groove without coming out.
In some preferred ways, as shown in fig. 11, the securing mechanism further includes a second motor 140, the second motor 140 being capable of providing power, and in some preferred ways, the second motor 140 being capable of providing both clockwise and counterclockwise motion; and the two motion modes of uniform speed and variable speed are adopted. Specifically, the second motor 140 can change the distance between the sensor pressing plate 135 and the sensor placing plate 134, so that the included angle between the sensor placing plate 134 and the sensor pressing plate 135 can be 0-90 degrees, the sensor can be automatically fixed or released, and the degree of automation is high, and manual fixation is not needed.
In some preferred embodiments, the second motor 140 may be fixedly mounted to the mounting plate 128, and in this embodiment, as shown in fig. 15 and 19, the second motor 140 is first coupled to the second motor bracket 142, and then the second motor bracket 142 is fixedly mounted to the mounting plate 128.
In some preferred forms, the second motor 140 is coupled to the sensor platen 135 via a timing belt 138, a timing wheel, and is capable of transmitting power to the second shaft 137 and the sensor platen 135 for rotational movement. In some preferred forms, as shown in fig. 15, 19, the first synchronizing wheel 139 is coupled to a second motor 140, the second synchronizing wheel 1391 is coupled to a sensor platen 135, the second synchronizing wheel 1391 is coupled to a second shaft 137, and the sensor platen 135 is also coupled to the second shaft 137; the second motor 140 rotates to drive the first synchronizing wheel 139 to rotate, the second synchronizing wheel 1391 is driven to rotate through the transmission of the transmission belt, accordingly, the second shaft 137 rotates, the sensor pressing plate 135 rotates along with the rotation of the second shaft, the sensor placing plate 134 rotates, and finally the purposes of pressing the sensor pressing plate 135, fixing the sensor placing plate 134 and fixing the sensor can be achieved.
In some preferred forms, as shown in fig. 20-21, the sensor placement plate 134 rotates about a third axis 141 (O3) relative to the sensor platen 135, and when the back of the sensor placement plate 134 contacts the boss side of the sensor platen 135, the sensor placement plate 134 cannot rotate clockwise due to mechanical stops, at which point the sensor placement plate 134 makes a maximum angle of 90 ° with the sensor platen 135, and the mechanism is in an open state, as shown in fig. 20. Defining the number of motor rotations as a software limit in the control module system program can thus avoid transitional counterclockwise or clockwise rotation of the sensor placement plate 134, resulting in an inability to better secure the sensor.
As shown in fig. 21, the first synchronizing wheel 139 rotates clockwise about the first axis O1, the second synchronizing wheel 1391 rotates clockwise about the second axis 137 (or O2) by transmission of the timing belt 138, the sensor platen 135 rotates clockwise about the second axis 137 (or O2) relative to the mounting plate 128, and the sensor placement plate 134 rotates counterclockwise about the third axis 141 (or O3) relative to the mounting plate 128. The angle between the sensor placing plate 134 and the sensor pressing plate 135 is reduced, and the fixing mechanism is in a transitional state.
As shown in fig. 22, when the first synchronizing wheel 139 continues to rotate clockwise around the first axis O1 for a certain number of turns, the sensor placing plate 134 cannot rotate counterclockwise due to mechanical limitation (the number of turns of the motor can be defined as a software limitation in the control module system program), the sensor placing plate 134 and the sensor pressing plate 135 have an included angle of 0 °, and the fixing mechanism is in a closed state.
In some preferred forms, the securing mechanism further includes a capture device including a sensor circuit board 130, the sensor circuit board 130 being coupled to the sensor platen 135, in some preferred forms, as shown in fig. 12-13, the sensor circuit board 130 is secured to the upper surface of the sensor platen 135 using a hex stud 131 and a set screw, in other embodiments, a snap-fit connection or a screw-in connection may be used. In some preferred embodiments, as shown in fig. 10, a connection terminal 132 is connected to the upper surface of the sensor circuit board 130, and a connection port is provided on the connection terminal 132. In some preferred forms, the sensor circuit board 130 has a spring contact 1321 attached thereto, the spring contact 1321 being configured to connect to the sensor contact 1326 for transmitting a sensing signal, in some preferred forms, as shown in fig. 12-13, the spring contact 1321 is secured between the sensor circuit board 130 and the sensor platen 135, the spring contact 1321 has an upper end positioned in an upper counterbore of the sensor circuit board 130, the spring contact 1321 has a lower end positioned in a lower counterbore of the sensor platen 135, and in some preferred forms, the lower counterbore of the sensor platen 135 includes two distinct apertures, the first aperture being larger than the second aperture, such that the lower end of the spring contact 1321 extends beyond the sensor platen 135 and the length of the spring contact 1321 extending beyond the sensor platen 135 is limited. In some preferred forms, the spring contact 1321 is a standard, commercially available, component, and the internal structure and travel path are shown in fig. 13.
In the prior art, as shown in fig. 35, the sensor includes an upper section 1322, a middle section 1323 and a lower section 1324, the middle section 1323 being a transition section, and the upper section 1322 and the lower section 1324 being connected together. The upper end of the upper segment 1322 is provided with an insulating layer 1325, the surface area of the upper segment 1322 is provided with a contact 1326 which can be connected with the elastic contact 1321, the lower segment 1324 is a detection segment, and the effective reaction length is different from the model of the sensor to be detected. The sensors are generally small and irregularly shaped, and it is not easy to put the sensors into the sensor placement plate 134.
In the invention, the sensors are connected in parallel, specifically, as shown in fig. 35, the insulating layer 1325 at the upper end of each sensor is connected with the insulating rod 1327, when the sensors need to be placed, the sensors are only needed to be placed on the sensor placing plate 134 by holding the insulating rod 1327, and the operation is simple and quick, so that a plurality of sensors can be placed in the sensor placing plate 134 at a time, batch placement of the sensors is realized, and the working efficiency is improved. In some preferred forms, each sensor is removably attached to the insulating rod 1327, such as by a snap fit, which facilitates removal of the sensor. In a specific case, a corresponding number of sensors may be placed according to the requirement, and the number of sensors may be one or more than two. In this embodiment, 8 sensors are connected to an insulating rod 1327.
In some preferred forms, as shown in FIG. 39, a lateral detent 1328 is provided on the surface of sensor placement plate 134 for detent of insulating rod 1327. In some preferred forms, as shown in fig. 36, the surface of the sensor placement plate 134 is further provided with a slot 1329, and the slot 1329 facilitates placement of the sensor and can fix the sensor so that the sensor is in a fixed state, and prevents the sensor from tilting or falling out of the sensor placement plate 134. In some preferred forms, the shape of the slot 1329 matches the shape of the sensor, in some preferred forms, the slot 1329 is shaped like a "Y", in some preferred forms, the open end of the slot 1329 is provided with a locating surface 1330, and the locating surface 1330 is capable of securing the upper section 1322 of the sensor when the sensor is placed in the slot 1329. In some preferred forms, the sensor placement plate 134 is further provided with a sensor 1331, and the sensor 1331 is capable of reading information such as the type, number, placement position, etc. of the sensors.
In some preferred forms, as shown in fig. 14, the lower surface of the sensor platen 135 is provided with a bump 1332 that can be snapped onto the lower portion of the slot 1329, so that the sensor platen 135 can be tightly combined with the sensor placement plate 134, and the elastic contact 1321 is in contact connection with the sensor contact 1326.
In some preferred ways, as shown in fig. 6, the wireless transmission circuit board 100 in the transmission module 1 is mounted on the back surface of the sensor pressing plate 135, so as to facilitate the transmission of the sensor signal, and in some preferred ways, an opening is provided on the sensor pressing plate 135, so that the quick-connect plug 101 extends out of the sensor pressing plate 135 and is inserted into a connection port on the connection terminal 132.
Generally, the sensor is placed in the sensor placing plate 134, and then the sensor pressing plate 135 presses the sensor placing plate 134, at this time, the elastic contact 1321 is in contact connection with the sensor contact 1326 and is capable of transmitting a signal to the sensor circuit board 130, and the sensor circuit board 130 transmits the sensor signal to the wireless transmission circuit board 100 through the connection terminal 132.
In some preferred forms, the reagent module 4 comprises reagent holding means, vortex generating means, reagent position adjusting means, the reagent holding means being capable of being used to hold reagents for detection; the vortex generating device is configured to enable reagents in the kit to generate vortex, mix the reagents uniformly, facilitate testing of mechanical properties and repeated accuracy of the sensor, and enable testing results to be more accurate. And the reagent position adjusting device is configured to be capable of adjusting the position of the reagent containing device and further adjusting the position of the reagent.
In some preferred forms, the reagent holding device comprises a kit comprising a plurality of reagent-holding wells. As shown in fig. 24, the kit may be a square kit 200, a round kit 201, or an eccentric kit in other preferred manners; the shape of the kit is not limited in the present invention, and any one may be selected according to actual needs in the specific implementation. The groove for containing the reagent can be a cylindrical groove or a groove similar to a centrifugal tube shape, so that the use amount is small, and the groove can also be of other shapes. In some preferred embodiments, as shown in fig. 37, the kit is a square kit 200, and the kit 200 has a plurality of cylindrical grooves for accommodating reagents, and the plurality of cylindrical grooves are spaced apart from each other and independent of each other.
In other preferred embodiments, as shown in fig. 38, the kit 201 includes a plurality of circles of the annular groove 2011, where the circle centers of the annular groove 2011 are the same, and the reagent may be stored inside the annular groove 2011. Different annular grooves 2011 may store the same reagent or different reagents inside. The annular groove 2011 not only can be used for storing a certain amount of reagent, but also is convenient for adding the reagent, and is favorable for shaking and mixing the reagent. In some preferred ways, as shown in fig. 38, a reagent sensing ring 2012 is provided in the annular recess 2011 for detecting how much reagent is in the volume, whether it is sufficient for detecting the assay.
In some preferred ways, as shown in fig. 37, a reagent sensor 2013 is provided in the groove for containing the reagent, and the reagent sensor 2013 can be used to detect whether the correct reagent is placed in the corresponding position; the reagent sensing loop 2012 can be used to detect whether a sufficient amount of reagent has been placed at a corresponding location. Both the reagent sensing ring 2012 and the reagent sensor 2013 can wirelessly transmit sensing data to the transmission module 1. In other preferred forms, as shown in fig. 37 (a), a sensing circuit board 2014 is provided at the bottom of the kit, and the sensing circuit board 2014 can be used to receive sensing data from the plurality of reagent sensors 2013, reagent sensing loops 2012 and can send the sensing data to the control module 6. The reagent sensing ring 2012, the reagent sensor 2013, and the sensing circuit board 2014 are all available in the prior art.
In some preferred forms, as shown in fig. 24, the vortex generating device includes a third motor 206, a first gear 203, a second gear 204, and a tray 202. In some preferred forms, the third motor 206 is fixedly coupled to the tray 202, the second gear 204 is coupled to the third motor 206, the first gear 203 is in contact meshed engagement with the second gear 204, and the first gear 203 is mounted to the fixed tray 202. In this embodiment, as shown in fig. 24, the outer cylindrical surface of the third motor 206 is screwed into the corresponding threaded hole on the tray 202 to be fixed to the step surface, the second gear 204 and the first gear 203 are respectively inserted into the rotating shaft of the third motor 206 and the boss of the tray 202, and are fixedly connected, and the gear sets (the second gear 204 and the first gear 203) can move in a meshing manner; in some preferred embodiments, the kit 201 is fixedly connected to the first gear 203, and as shown in fig. 40, the center of the kit 201 is connected to the center of the first gear 203 by a screw. In other preferred embodiments, the kit 201 is coupled to the first gear 203 by a snap-fit connection. When the third motor 206 is started, the second gear 204 rotates, and the first gear 203 also rotates, and accordingly, the reagent kit 201 rotates, so that the reagent in the reagent kit 201 generates vortex, the reagent is uniformly mixed, vortex detection is facilitated, and the mechanical property and the repetition accuracy of the sensor are conveniently detected. In some preferred modes, the pitch circle diameter of the first gear is larger than that of the second gear, so that the contact area of the first gear and the kit is larger, the kit can be better supported, and the kit is driven to rotate. Of course, the pitch diameters of the first gear and the second gear may be equal or the pitch diameter of the first gear may be smaller. In some preferred embodiments, the first gear is higher than the second gear, so that the first gear does not interfere with the second gear when the first gear rotates the cartridge.
In other preferred embodiments, only one gear 204 is used, the gear 204 being coupled to the kit; the third motor 206 rotates to drive the gear 204 to rotate, and the reagent kit connected with the gear 204 can rotate, so as to mix the reagents uniformly.
In some preferred forms, as shown in fig. 24, the reagent position adjusting apparatus includes a fourth motor 221, a second screw 213, and a second coupling 219. The fourth motor 221 is connected to the second coupling 219, the second coupling 219 is connected to the second screw 213, the fourth motor 221 is capable of providing power, the second coupling 219 connects the fourth motor 221 to the second screw 213, and motion and power are transmitted. If the fourth motor 221 is started, the second screw 213 can be rotated accordingly. In some preferred manners, the fourth motor 221 can drive the second screw 213 to perform a clockwise or counterclockwise motion; the fourth motor 221 has two motion modes of uniform speed and variable speed. In other embodiments, instead of using a screw, a gear may be used in combination with a toothed plate to adjust the horizontal position of the kit 201.
In other preferred forms, instead of a lead screw, as shown in fig. 49-51, a motor 400, a gear assembly (including a third gear 401, a fourth gear 402), a conveyor belt 403, a slider 404, and a stop device, wherein the stop device employs a housing 405 with an opening, the motor 400 is mounted inside the housing 405, and the third gear 401 and the fourth gear 402 are also mounted inside the housing 405; the motor 400 is connected to the third gear 401, the third gear 401 and the fourth gear 402 are connected to the conveyor belt 403, the slider 404 is connected to the conveyor belt 403, and the slider 404 is directly or indirectly connected to the reagent cartridge 200, and in this embodiment, as shown in fig. 51, the slider 404 is connected to the tray 202, and the reagent cartridge 200 is mounted inside the tray 202. The rotation of the motor 400 can drive the third gear 401 and the fourth gear 402 to rotate, the conveyor belt 403 moves, the sliding block 404 moves, the reagent kit 200 can move at the opening, and the length of the opening determines the moving distance of the reagent kit.
In some preferred ways, the fourth motor 221 can be mounted and fixed on the bottom plate 222, and in some preferred ways, the fourth motor 221 is mounted on the first support 220, and the first support 220 can be fixed on the bottom plate 222 of the frame module 8, thereby enabling the fixation of the fourth motor 221.
In some preferred embodiments, the reagent position adjusting apparatus further includes a limiting structure, and in some preferred embodiments, the limiting structure includes a second support 215 and a third support 207, where the second support 215 and the third support 207 may be respectively connected and fixed to the bottom plate 222. In this embodiment, as shown in fig. 24, the hole sites at the bottoms of the second support 215 and the third support 207 are aligned with the corresponding hole sites of the bottom plate 222 and are tightly attached to the step surface, and the screws are screwed into the corresponding hole sites respectively to lock.
In some preferred manners, as shown in fig. 24, a first bearing 216 and a second bearing 214 are connected to the second support, so as to fixedly connect the second screw, the motor shaft is connected to a second coupling 219, and the second coupling 219 is connected to the second screw 213. In this embodiment, as shown in fig. 24, the fourth motor 221 is mounted on the first support 220 to the motor mounting surface, and the screws are screwed into the corresponding holes to lock; one end of the second coupler 219 penetrates into the rotating shaft of the motor 221, and the other end penetrates into the second screw rod 213 to reach the step surface, and is fixedly connected.
In some preferred manners, as shown in fig. 24, the second support 215 is provided with a mounting hole, in which the first bearing 216 and the second bearing 214 are mounted, and the third support 207 is also provided with a mounting hole, in which the third bearing 209 is mounted, and one end of the second screw 213 is connected to the second bearing 214, and the other end is connected to the third bearing 209. In some preferred forms, a second screw sleeve 212 is connected to the second screw 213 at a central position, and when the second screw 213 is rotated, the second screw sleeve 212 can perform a linear motion between the second support 215 and the third support 207. In some preferred forms, a second screw sleeve 212 is connected to the tray 202, the second screw sleeve 212 being capable of supporting the tray 202 and being capable of moving the tray 202 in a straight line along the screw axis, and in some preferred forms, as shown in fig. 24, the tray 202 is fixedly connected to the upper portion of the screw sleeve 211 by means of screws 205.
In some preferred embodiments, the second support 215 and the third support 207 are further connected with a first optical axis 210 and a second optical axis 2101, in this embodiment, as shown in fig. 24, the second support 215 and the third support 207 are provided with connecting holes, and the first optical axis 210 and the second optical axis 2101 can be connected and fixed on the second support 215 and the third support 207. In some preferred modes, the first optical axis 210 and the second optical axis 2101 are respectively connected with the first optical axis sleeve 211 and the second optical axis sleeve 2102, the first optical axis sleeve 211 and the second optical axis sleeve 2102 are respectively connected with the tray 202, in some preferred modes, the tray 202 is fixed on the first optical axis sleeve 211 and the second optical axis sleeve 2102 by adopting screws, so that a part of the weight of the kit 201 can be shared by the second screw rod 213, the kit 201 is supported together, and the structure is more stable. In some preferred forms, the first optical axis 210 and the second optical axis 2101 are located on two sides of the second screw 213, respectively. The fourth motor 221 is started, the fourth motor 221 can drive the second coupler 219 to rotate, and the second coupler 219 drives the second screw rod 213 to rotate, so that the second screw rod sleeve 212 and the tray 202 can do forward or backward linear reciprocating motion, and further the position of a reagent in the reagent box 201 can be changed, and the detection by a sensor is facilitated; the second support 215 and the third support 207 at two ends of the first optical axis 210 are mechanical limits, and can limit the movement range of the screw sleeve (meanwhile, the rotation number of the motor is defined as software limit in the system program). In some preferred forms, the fourth motor 221 is a stepper motor, and the second screw 213 and the second screw sleeve 212 are ball screws. The stepping motor can realize accurate control according to constant rotation characteristics of the stepping angle; the ball screw can realize higher displacement precision and transmission efficiency, extremely low shaking coefficient and friction resistance and higher repeated positioning precision during reciprocating movement.
In some preferred ways, as shown in fig. 4, the transmission module 1 includes a wireless transmitter 104, a mounting bracket 105, and a data transmission device; the data transmission device comprises a quick connector 101 and a wireless transmission circuit board 100, wherein the quick connector 101 is connected with the wireless transmission circuit board 100 through a connecting wire, and the wireless transmission circuit board 100 is provided with a data input element 102 and a data output element 103. As shown in fig. 5, the wireless transmitter 104 is connected to the mounting bracket 105, and the wireless transmitter 104 is mounted on the side surface of the frame module 8 by the mounting bracket 105 and the set screw 111. As shown in fig. 6, the wireless transmission circuit board 100 is fastened to the sensor pressing plate 135 using the supporting column 110 and the set screw 111; the quick connect plug 101 may be inserted into a connection port of the sensor platen 135. The data information is transferred to the wireless transmitter 104 through the wireless transmission circuit board 100, the data input element 102 and the data output element 103. The wireless transmitter 104 converts the data into wireless signals through wireless technology and sends the wireless signals to the control module 6 according to the requirements of the interaction module 2. The wireless transmitter 104 is also capable of transmitting wireless signals to an external signal receiving device.
The wireless transmitter 104 in the present invention adopts an existing conventional wireless transmitter, and the transmission mode can adopt bluetooth transmission or wireless SmartAir transmission.
Bluetooth transmission has the following advantages:
a. Bluetooth uses the universal 2.4G ISM frequency band which can be used in the world without permission; b. the Bluetooth device is miniaturized; c. the data transmission between the Bluetooth devices does not need complex setting; d. the data transmission rate is high, and the transmission distance is long; e. has good anti-interference capability.
The Bluetooth transmission can be well used as a wireless transmission link among the sensor module 3, the reagent module 4, the driving module 7 and the control module 6; the method can be perfectly compatible with the PC end and the client end, and is a preferred mode of the method.
Wireless SmartAir transmission has the following advantages:
a. ultra-high rate b.ultra-low power consumption c.ultra-low delay d.ultra-low cost e.ultra-low radiation.
The wireless SmartAir transmission can be well used as a wireless transmission link among the interaction module 2, the driving module 7 and the control module 6.
As shown in fig. 26, the power supply module 5 includes a transformer 5111, an external three-phase socket 1151, and a power switch 116, and the transformer 5111 is connected to the external three-phase socket 1151 and the power switch 116 via connection lines, respectively. In some preferred forms, an INPUT+ port, an INPUT-port, a ground port, an OUTPUT+ port, an OUTPUT-port are provided within transformer 5111; the power switch 116 includes a switch button, and an INPUT + port, an INPUT-port, and a ground port are provided in the external three-phase jack 1151.
The main function of the power supply module is to continuously convert external voltage into voltage used by the whole device through a transformer 5111, wherein INPUT+ and INPUT-are INPUT ends; OUPUT +, OUTPUT-are OUTPUTs. Under normal power conditions, the power may be manually turned off and on by the power switch 116.
As shown in fig. 27, the control module 6 includes a single chip microcomputer 300, an output terminal 301, an input terminal 302, a wireless transmission element 303, a data input/output serial port 304, and a power supply terminal 305.
As shown in fig. 28, the single chip microcomputer 300 writes program instructions through the data input/output serial port 304, and can read/store system data, which is the central core of the whole device. The power supply module 4 supplies power to the power supply terminal 305, and activates the rest elements of the control module 6. The wireless transmission element 303 wirelessly receives/transmits signals to the transmission module 1, and the control module 6 can wire-transmit signals to the interaction module 2 and the driving module 7 through the input end 302 and the output end 301.
As shown in fig. 28, the driving module 7 includes an output terminal 310 and an input terminal 311. As shown in fig. 28, the signal of the control module 6 can be transmitted to the driving module 7 through the input terminal 311 by wire, and then transmitted to the sensor module 3 and the reagent module 4 through the output terminal 310 by wire.
In some preferred ways, as shown in fig. 7, the interaction module 2 includes a touch screen 115, and a USB data port 112, a power supply wire 113 and a control module connecting wire 114 are disposed at the lower end of the touch screen 115. The control module 6 and the interaction module 2 are connected by wires, i.e. control module connection wires 114.
As shown in fig. 8, after the corresponding sensors and reagents are placed in the sensor module 3 and the reagent module 4, the reagent sensor 2013 and/or the reagent sensing ring 2012 transmit the collected reagent information to the transmission module 1, the sensor collects the sensor placement position signal and can transmit it to the transmission module 1, the sensor and the reagent generate chemical reaction identification valid/invalid signals and then transmit the signals to the transmission module 1, and the wireless transmission circuit board 100 in the transmission module 1 receives the signals and can send them to the control module 6.
When the control module 6 successfully recognizes the signal, the data is transmitted to the interaction module 2 and the driving module 7 through wires after being processed. At this time, the interactive module 2 displays a program interface indicating that the next step operation can be performed.
When the control module 6 identifies the reagent and/or sensor is not properly placed or the object is wrong, the touch screen 115 may be voice interactive, key digital display interactive or touch panel interactive.
The developer can complete each instruction by talking to the voice interactive touch screen 115. The user identity can be identified through voice, if not a research and development personnel, the touch screen system gives out alarm sounds and the system is closed; the research and development personnel interact with the touch screen system through the input of the key digital display interactive touch screen 115, and the screen of the touch screen 115 can display characters and graphics; when a developer contacts a graphic button on the screen through the touch panel interactive touch screen 115, the on-screen haptic feedback system can drive various connection means.
Fig. 9 is a circuit connection diagram of the interaction module 2 and other modules, and as can be seen from the figure, the motors (including the first motor 121, the second motor 140, the third motor 206 and the fourth motor 221) are connected with the driving module 7, and can provide power, the driving module 7 is connected with the control module 6, the control module 6 is connected with the touch screen 115, and the control module 6 is also connected with the power supply module 5.
In the control module 6, the single chip microcomputer 300 is a core control component, is connected with the touch display screen through a serial port, is communicated through the serial port, performs corresponding operation according to touch input of a user, transmits current information acquired by a sensor at present through the Bluetooth module and the upper computer, and the power supply box is a power supply module for performing AC-DC conversion to supply power for the whole control system, and the single chip microcomputer 300 performs stroke control on the stepping motor through a stepping motor driver, so that the sensor reaches a set position of the kit, the stroke switch is responsible for position determination, and when the stepping motor detects the stroke switch, the transmission mechanism immediately stops and maintains the current position. Each stepper motor is provided with two travel switches defining a start and an operating position. In the embodiment, the adopted singlechip and stepping motor are all existing in the prior art, and the structure, principle and connection relation of the singlechip and the stepping motor are not improved.
A method for detecting sensor performance, which can employ the multi-channel detection device described above, includes the following steps:
(1) Placing the sensor into the sensor placement plate 134;
(2) Reading sensor data, wherein the sensor data comprises the model number, the number and the like of the sensors;
(3) Selecting sensor detection parameters, wherein the sensor detection parameters comprise sensitivity, service life, mechanical properties, repetition accuracy, corrosion resistance and the like;
(4) Putting corresponding detection reagent;
(5) Selecting a detection scheme, wherein the detection scheme comprises static detection, vibration detection, vortex detection, reciprocating detection and compound detection;
(6) Detecting in real time;
(7) The real-time detection result is displayed, and the detection result can be in the form of a character table or a graph, and as shown in fig. 34, the detection result can be derived. In some preferred ways, the detection result may be transmitted to the PC side or the mobile side through bluetooth, wiFi.
In some preferred manners, in step (1), after the sensor is placed in the sensor placement board 134, the sensor 1331 checks the sensor placement position information and transmits the data information to the transmission module 1, the wireless transmission circuit board 100 in the transmission module 1 receives the signal and can send it to the control module 6 (or the sensor 1331 can directly and wirelessly transmit the collected sensor placement position information to the control module 6), and the control module 6 performs analysis to determine whether the sensor placement position is correct, and if so, the data is transmitted to the interaction module 2 and the driving module 7 through wired transmission after being processed. At this time, the interaction module 2 displays a program interface, which indicates that detection can be performed; if not, the data is transmitted to the interaction module 2 through a wire after being processed, and at this time, the interaction module 2 displays that the reagent and/or the sensor is placed incorrectly or the object is placed incorrectly, and the touch screen 115 can be a voice interaction type, a key digital display interaction type or a touch panel interaction type.
In some preferred forms, the specific process of step (2) is: the singlechip 300 in the control module 6 reads the sensor data information and can transmit the data information to the interaction module 2, and the interaction module 2 displays the model number and the number of the sensors, as shown in fig. 34.
In some preferred manners, in step (3), after the detection scheme is selected, the interaction module 2 feeds back information to the control module 6, the control module 6 performs analysis processing on the information and then transmits the information to the interaction module 2, and the interaction module 2 displays the interface of the next step: the reagent is prompted to be placed in the kit.
In some preferred manners, in step (4), after the corresponding detection reagent is placed, the reagent sensor 2013 and/or the reagent sensing ring 2012 can transmit the collected reagent information (the reagent information includes the amount of the reagent and whether the correct reagent is placed) to the transmission module 1, the wireless transmission circuit board 100 in the transmission module 1 receives the signal and can send it to the control module 6, the singlechip 300 of the control module 6 analyzes and judges whether the received reagent information is matched with the reagent information stored in advance (different sensor detection parameters need to be checked by using different reagents, and these information are stored in the singlechip 300 in advance), and if so, the singlechip 300 transmits the data to the interaction module 2 after processing; at this time, the interaction module 2 displays an operation interface of the next step; if the reagent information is not matched, the singlechip 300 processes the data and transmits the processed data to the interaction module 2; the interaction module 2 displays that the reagent amount is insufficient and/or that the reagent is wrong, etc.
In some preferred manners, in step (5), after the detection scheme is selected, the interaction module 2 transmits information to the control module 6, and after the control module 6 performs analysis processing on the information, the information is transmitted to the driving module 7. As shown in fig. 31, parameters that can be used for detection in stationary detection are sensitivity and corrosion resistance, and parameters that can be used for detection in vibration detection are sensitivity and service life; the parameters which can be used for detection in vortex detection are mechanical property and repetition precision, and the parameters which can be used for detection in reciprocating detection are sensitivity and repetition precision; the parameters of the composite detection, which can be used for detection, are sensitivity, repetition accuracy, service life, mechanical property and corrosion resistance; the corresponding detection scheme is selected according to the detection parameters selected in the previous step.
In some preferred modes, in step (6), after the driving module receives the data information, the driving motor works to perform the detection operation. As shown in fig. 44, the specific procedure for performing the rest detection is: the driving module 7 transmits information to the sensor module 3 and the reagent module 4, a second motor 140 in the sensor module 3 works to drive a first synchronous wheel 139, a synchronous belt 138 and a second synchronous wheel 1391 to move, a sensor pressing plate 135 rotates, a sensor placing plate 134 rotates, an included angle between the sensor pressing plate 135 and the sensor placing plate 134 gradually decreases, and finally the sensor pressing plate 135 presses and fixes the sensor placing plate 134; according to the position of the sensor, the fourth motor 221 of the reagent module 4 works to drive the second screw 213 to rotate, so that the reagent kit moves backward or forward to the working position (in the specific implementation, the reagent kit 201 moves to the position below the sensor, so that the sensor is conveniently inserted into the reagent for detection). The first motor 121 in the sensor module operates with the first screw 124 rotating and the first screw sleeve 127 and mounting plate 128 moving downward, with the sensor moving downward to immerse the reagent for detection.
In some preferred manners, in step (6), as shown in fig. 46, the specific process of performing vibration detection is: based on stationary detection, the sensor reciprocates up and down in the reagent and/or the sensor reciprocates forward and backward in the reagent. In some preferred embodiments, the first motor 121 rotates counterclockwise (or rotates clockwise) to rotate the first screw 124, the first screw sleeve 127 moves downward (or moves upward) with the mounting plate 128, the sensor moves downward (or moves upward) in the reagent, and the sensor performs detection during the upward and downward reciprocating movement, so that the reciprocating detection result of the sensor at different depths of the reagent can be obtained. In some preferred modes, the fourth motor 221 rotates anticlockwise (or rotates clockwise) to drive the second screw 213 to rotate, the second screw sleeve 212 moves forwards (or moves backwards) with the reagent kit, the reagent moves forwards (or moves backwards) with the reagent kit, and the sensor completes detection in the process of reciprocating the reagent forwards and backwards, so that the reciprocating detection result of the sensor at different horizontal positions of the reagent can be obtained. In some preferred approaches, the sensor reciprocates up and down in the reagent while the sensor reciprocates forward and backward in the reagent, during which the sensor completes the detection.
In some preferred modes, in step (6), as shown in fig. 47, the specific process of performing vortex detection is: on the basis of static detection, the third motor 206 in the reagent module 4 works (clockwise or anticlockwise) to drive the second gear 204 to work, the first gear 203 rotates along with the second motor, the reagent box 201 connected with the first gear 203 rotates, the reagents are uniformly mixed, and the sensor detects in the state.
In some preferred modes, in step (6), as shown in fig. 46, the specific process of performing the reciprocation detection is identical to the process of the vibration detection, but the amplitude of the motion of the vibration detection is smaller than that of the reciprocation detection, and the frequency of the vibration detection is lower than that of the reciprocation detection. The preferred amplitude of motion for vibration detection is +/-0.5mm, and the preferred frequency is 0.2s; the preferred amplitude of motion for the reciprocation detection is +/-2mm, and the preferred frequency is 1s.
In some preferred modes, in step (6), as shown in fig. 48, the specific process of performing the composite detection is: both reciprocating and vortex detection. The reciprocation detection is the same as the reciprocation detection step described above, and the vortex detection is the same as the vortex detection step described above.
Some of the steps in the detection method described above may be performed in the interaction module 2. The operation interface of the interaction module 2 is shown in fig. 33-34.
The device of the invention not only can be used for detecting some performance parameters of the sensor, but also can be used for detecting the reagent to obtain the relevant components of the reagent. As shown in fig. 32, when detecting a reagent, (1) firstly, a reagent to be detected is placed in the reagent sensor 2013 and/or the reagent sensing ring 2012, collected reagent information (the quantity of the reagent information includes the quantity of the reagent) can be transmitted to the transmission module 1, the wireless transmission circuit board 100 in the transmission module 1 receives a signal and can send the signal to the control module 6, (2) the singlechip 300 of the control module 6 analyzes and judges whether the received reagent information is matched with the reagent information stored in advance (whether the quantity of the reagent is enough for detection), and if so, the singlechip 300 processes the data and then transmits the data to the interaction module 2; at this time, the interaction module 2 displays the volume of the reagent, the number of the reagent and the number of the reagent; if the reagent information is not matched, the singlechip 300 processes the data and transmits the processed data to the interaction module 2; at this time, the interactive module 2 displays insufficient amounts of reagents, etc. (3) Selecting components to be detected, wherein the components to be detected comprise saccharides, enzymes, lipids, minerals, metals and the like; for example, sugar in the detection reagent is selected for reagent No. 2, and enzyme in the detection reagent can be selected for reagent No. 8. (4) The corresponding sensors are put in, the sensor 1331 reads the types, the number, the placement positions and the like of the sensors and transmits the information to the transmission module 1, the wireless transmission circuit board 100 in the transmission module 1 receives the signals and can send the signals to the control module 6, the singlechip 300 of the control module 6 analyzes and judges whether the received sensor information is matched with the pre-stored sensor information, and if the received sensor information is not matched with the pre-stored sensor information, the interaction module gives a prompt; if so, entering the next step; (5) Selecting a detection scheme, wherein the detection scheme comprises static detection, vibration detection, vortex detection, reciprocating detection, compound detection and the like; (6) And (7) real-time detection is carried out, the real-time detection result is displayed, the detection result can be in the form of a character table or a graph, and the detection result can be transmitted to a PC end or a mobile end through Bluetooth and WiFi.
Example 2
In this embodiment, the securing mechanism includes a sensor placement plate 134 (the securing mechanism does not include a sensor platen), the sensor placement plate 134 being fixedly mounted or indirectly connected to the mounting plate 128; the sensor placing plate 134 can be used to place and fix the sensor 133.
The sensor placement plate 134 is further provided with a slot 1329 on a surface thereof, the slot 1329 is convenient for placing the sensor, and can fix the sensor, so that the sensor is in a certain fixed state, and the sensor is prevented from tilting or separating from the sensor placement plate 134. In some preferred forms, the shape of the slot 1329 matches the shape of the sensor, and in some preferred forms, the open end of the slot 1329 is provided with a locating surface 1330, the locating surface 1330 being capable of securing the upper section 1322 of the sensor when the sensor is placed in the slot 1329.
In some preferred modes, a sensor is further arranged inside the sensor placing board slot, and the sensor can read information such as the type, the number, the placing position, the sensor detection signal and the like of the sensor and transmit the detected signal to the control module through wires or wirelessly.
In some preferred forms, after the sensor is placed in the detent 1329, the sensor contacts on the sensor, and the sensor may receive signals regarding the sensor, such as the type, number, placement location, sensor detection signal, etc.
The sensor inductor can adopt the existing sensor inductor in the prior art, and the structure and the working principle of the sensor inductor are not improved.
Other implementations in this example may be the same as example 1.
It will be apparent that the described embodiments are only some, but not all, embodiments of the invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the present invention without making any inventive effort, shall fall within the scope of the present invention.

Claims (14)

1. The multichannel detection device is characterized by comprising a sensor module, wherein the sensor module comprises a fixing mechanism, the fixing mechanism comprises a sensor placing plate, a sensor pressing plate and a power device, the sensor placing plate is connected with the sensor pressing plate, the sensor pressing plate is connected with the power device, and the sensor pressing plate can press the sensor placing plate to fix a sensor under the driving of the power device;
The detection device also comprises a reagent module, wherein the reagent module comprises a reagent containing device and a vortex generating device, the reagent containing device is connected with the vortex generating device, and the reagent containing device can be used for containing a reagent for detection; the vortex generating device is configured to enable reagents in the kit to generate vortex, mix the reagents uniformly, facilitate vortex detection and be used for testing the mechanical property and the repetition accuracy of the sensor.
2. The multi-channel detector of claim 1, wherein the power device is a second motor, and wherein the motor is coupled to the sensor platen.
3. The multi-channel detector according to claim 2, wherein the second motor drives the sensor platen to rotate through a synchronous belt and a synchronous wheel, and the synchronous wheel comprises a first synchronous wheel and a second synchronous wheel.
4. A multi-channel inspection device according to claim 3 wherein the second motor is coupled to a first synchronizing wheel, the first synchronizing wheel is coupled to a timing belt, the timing belt is coupled to a second synchronizing wheel, the second synchronizing wheel is coupled to a hinge shaft, and the sensor platen is also coupled to the hinge shaft.
5. The multi-channel detector according to claim 1, wherein the sensor placement plate has a slot on a surface thereof for placing the sensor.
6. The multi-channel detector according to claim 5, wherein the open end of the slot is provided with a positioning surface.
7. The multi-channel inspection device according to claim 6, wherein the sensor platen has a protrusion on its lower surface that can be engaged with the lower portion of the slot.
8. The multi-channel detector of claim 1, wherein the sensor platen is connected to the sensor placement plate by a hinge.
9. The multi-channel detector according to claim 5, wherein the sensor is disposed in the slot.
10. The multi-channel inspection device according to claim 1, wherein the sensor module further comprises a height adjusting device comprising a first motor for providing driving force, a power transmission device for transmitting power, and a mounting plate for directly or indirectly mounting the sensor placement plate, the first motor being connected to the power transmission device, the mounting plate being connected to the power transmission device, the power transmission device comprising a screw rod which is rotated by the driving of the first motor, the mounting plate and the sensor being movable upward or downward.
11. The multi-channel detector of claim 10, wherein the power transmission device further comprises a coupling, and the coupling is respectively connected with the first motor and the screw rod.
12. The multi-channel detector of claim 10, wherein the power transmission device further comprises a screw sleeve coupled to the mounting plate.
13. The multi-channel detector of claim 10, wherein the height adjustment device further comprises a limiting assembly; the limiting assembly comprises a polish rod, a polish rod sleeve and a supporting seat, wherein the polish rod is connected with the polish rod sleeve, and the polish rod sleeve is connected with the mounting plate.
14. The multi-channel assay device of claim 1 wherein the reagent holding means comprises a kit, the vortex generating means comprises a third motor, a gear and a tray, the third motor is connected to the tray, the third motor is further connected to the gear, the gear is further connected to the kit, the third motor drives the gear to rotate, and the kit rotates.
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