CN112107758B

CN112107758B - Infusion pump working method, infusion pump, medical equipment and storage medium

Info

Publication number: CN112107758B
Application number: CN201910538975.2A
Authority: CN
Inventors: 张鹏; 彭名旭; 左鹏飞
Original assignee: Shenzhen Mindray Scientific Co Ltd
Current assignee: Shenzhen Mindray Scientific Co Ltd
Priority date: 2019-06-20
Filing date: 2019-06-20
Publication date: 2022-11-04
Anticipated expiration: 2039-06-20
Also published as: CN112107758A

Abstract

The invention discloses an infusion pump, which is used in cooperation with an infusion apparatus and used for executing infusion operation set by a user according to liquid configured by the user; the infusion pump comprises infusion pump power equipment, an infusion channel, a sensor, a processor, a liquid stopping clamp, a storage and an output interface; the invention also discloses an infusion pump working method, medical equipment and a storage medium.

Description

Infusion pump working method, infusion pump, medical equipment and storage medium

Technical Field

The invention relates to an infusion pump, in particular to an infusion pump working method, an infusion pump, medical equipment and a storage medium.

Background

Intravenous infusion is a common administration mode in clinical treatment, and the requirement of intravenous infusion speed is different according to the property of medicaments and the constitution of patients. The expected treatment effect is difficult to achieve even if the infusion is too fast or too slow, and the nursing safety is even influenced. The infusion pump is infusion equipment capable of controlling the flow rate of infusion, so that the infusion speed and the dosage can meet the requirements of users. In the infusion process of the infusion pump, bubbles are often generated due to the infusion of liquid, the infusion apparatus, the operation and other reasons; if the infusion pump is not able to timely find a single large bubble in the infusion set and handle it accordingly, the safety of the patient may be compromised. However, in the process of detecting bubbles in an infusion apparatus through a bubble sensor, the sensing signal of the existing infusion pump greatly influences the accuracy of monitoring the bubbles in the infusion apparatus due to the discreteness.

Disclosure of Invention

The embodiment of the invention provides an infusion pump working method, an infusion pump, medical equipment and a storage medium, which can accurately determine the existence degree of bubbles in an infusion apparatus through the output signal of a bubble sensor, so that the infusion pump can perform corresponding processing according to the existence degree of the bubbles, and has the advantages of high safety performance and good user experience.

The embodiment of the invention provides an infusion pump, which is used for being matched with an infusion apparatus for use and executing infusion operation set by a user according to liquid configured by the user; the infusion pump comprises an infusion pump driving mechanism, an infusion pipeline, a sensor, a processor, a memory, a liquid stopping clamp and an output interface; wherein the infusion pump drive mechanism comprises a pump blade; the infusion pipeline is used for arranging the infusion apparatus; the sensor comprises a sensing signal transmitting end and a sensing signal receiving end, the sensing signal transmitting end is used for transmitting a sensing signal, the sensing signal receiving end is used for receiving a feedback signal, the feedback signal is a signal formed by the change of the sensing signal after passing through the infusion apparatus, and the sensing signal transmitting end and the sensing signal receiving end are arranged along the side edge of the infusion apparatus; the sensing signal transmitting end is used for transmitting at least two sensing signals based on different transmitting frequencies; the processor is used for driving the sensing signal transmitting terminal to transmit at least two sensing signals based on different transmitting frequencies, correspondingly receiving feedback signals fed back based on the sensing signals, and executing one of the following events:

driving the infusion pump driving mechanism to keep a liquid stopping state and sending out reminding information through the output interface; or alternatively

Updating the accumulated bubble amount and outputting the accumulated bubble amount through the output interface; or

And driving the infusion pump driving mechanism to keep an infusion state.

The embodiment of the invention also provides a working method of the infusion pump, which is applied to the infusion pump, wherein the infusion pump is used for being matched with an infusion apparatus for use, and the infusion operation set by a user is executed according to the liquid configured by the user;

the method comprises the following steps:

transmitting at least two sensing signals with different transmitting frequencies;

receiving feedback signals corresponding to a plurality of sensing signals;

performing one of the following events:

keeping a liquid stopping state and sending out reminding information; or

Updating the accumulated bubble amount and outputting the accumulated bubble amount; or

The transfusion state is maintained.

The embodiment of the invention also provides medical equipment, the medical equipment is used for being connected with the infusion pump provided by the invention through the output interface, and the medical equipment is provided with display equipment which is used for displaying information output by the output interface.

The embodiment of the invention also provides a storage medium, which stores executable instructions and is configured to cause a processor to execute the executable instructions to realize the working method of the infusion pump provided by the invention.

The embodiment of the invention provides an infusion pump working method, an infusion pump, medical equipment and a storage medium, wherein at least two sensing signals with different emission frequencies are emitted; the device receives a plurality of feedback signals corresponding to the sensing signals, executes corresponding events according to the corresponding feedback signals, improves the accuracy of monitoring the bubbles in the infusion apparatus, is beneficial to the infusion pump to execute the corresponding events according to the corresponding feedback signals, reduces misjudgments of the existence degree of the bubbles, and has high safety and good user experience.

Drawings

FIG. 1 is a block diagram of an apparatus provided by an embodiment of the present invention;

FIGS. 2A 2D are schematic views showing the form of bubbles in the embodiment of the present invention;

FIG. 3 is a schematic diagram of an alternative configuration of an infusion pump according to an embodiment of the present invention;

FIG. 4 is a schematic diagram illustrating the variation of the output amplitude of the feedback signal of the bubble sensor in accordance with the present invention;

FIG. 5 is a schematic diagram of an infusion pump operating method according to an embodiment of the present invention;

FIG. 6 is an alternative configuration of an infusion pump in accordance with an embodiment of the present invention;

FIG. 7 is an alternative configuration of an infusion pump in accordance with an embodiment of the present invention;

FIG. 8 is a schematic diagram of feedback signals of different frequencies for the bubble sensor of the present invention;

FIG. 9 is an alternative configuration of an infusion pump in accordance with an embodiment of the present invention;

FIG. 10 is a flow chart of the determination of the presence of air bubbles using the infusion pump of the present invention;

FIGS. 10A to 10C are schematic views showing the change of bubbles in the embodiment of the present invention;

FIG. 11 is a flow chart of the determination of the presence of air bubbles using the infusion pump of the present invention;

FIG. 12 is a schematic diagram of the output of the feedback signal according to the embodiment of the present invention;

FIG. 13 is a flow chart of the determination of the presence of air bubbles using the infusion pump of the present invention;

FIG. 14 is a graph showing the resonant frequencies of the feedback signal for different transmission frequencies of the bubble sensor of the present invention;

fig. 15 shows a schematic diagram of the feedback signal output amplitudes of 3 different bubble sensors according to the present invention.

Detailed Description

Reference will now be made in detail to the embodiments, examples of which are illustrated in the accompanying drawings. In the following detailed description, numerous specific details are set forth in order to provide a thorough understanding of various described embodiments. However, it will be understood by those of ordinary skill in the art that various described embodiments may be practiced without these specific details. In other instances, well-known methods, procedures, components, circuits, and networks have not been described in detail as not to unnecessarily obscure aspects of the present invention.

It will also be understood that, although the terms first, second, etc. may be used herein to describe various elements or other objects in some instances, these elements or objects should not be limited by these terms. These terms are only used to distinguish one element/object from another element/object.

The terminology used in the description of the various described embodiments herein is for the purpose of describing particular embodiments only and is not intended to be limiting. As used in the description of the various described embodiments and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It will also be understood that the term "and/or" as used herein refers to and encompasses any and all possible combinations of one or more of the associated listed items. It will be further understood that the terms "comprises" and/or "comprising," when used in this specification, specify the presence of stated features, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, steps, operations, elements, and/or components.

As used herein, the term "if" may be interpreted to mean "when 8230; \8230;," "in response to a determination," or "in response to a detection," depending on the context. Similarly, depending on the context, the phrase "if it is determined \8230;" or "if a [ stated condition or event ] is detected" may be interpreted to mean "upon determining 8230; \8230, time", "in response to determining 8230; \8230;", "upon detecting [ stated condition or event ] or" in response to detecting [ stated condition or event ] meaning.

Fig. 1 is a block diagram of an iv set provided in an embodiment of the present invention. The iv set 100 includes a control platform 102, memory 104, a power supply system 106, an input/output (I/O) system 108, RF circuitry 120, an external port 122, audio circuitry 124, monitoring circuitry 126, protection circuitry 128, power driver circuitry 130, a drop count sensor 132, a bubble sensor 134, and a pressure sensor 136, which communicate via one or more communication buses or signal lines 110. Wherein the control platform 102 includes a processor 150 and a peripheral interface 152.

The iv set 100 may be any medical device that performs an infusion operation set by a user based on a fluid configured by the user to controllably deliver a configured medical fluid into a patient, including but not limited to infusion pumps, syringe pumps, pain pumps, nutritional pumps, insulin pumps, and the like, and may include combinations of two or more thereof. In some embodiments, the intravenous infusion device may be used with an infusion set (e.g., tubing, syringe). It should be understood that the iv set 100 is merely an example and that the components of the medical device may have more or fewer components than shown, or a different configuration of components. The various components described in conjunction with fig. 1 may be implemented in hardware, software, or a combination of hardware and software, including one or more signal processing and/or application specific integrated circuits.

The memory 104 may include high-speed random access memory and may also include non-volatile memory, such as one or more magnetic disk storage devices, flash memory devices, or other non-volatile solid-state storage devices. In certain embodiments, the memory 104 may also include memory remote from the one or more processors 150, such as network-attached memory accessed via the RF circuitry 120 or the external port 122 and a communication network (not shown), which may be the internet, one or more intranets, a Local Area Network (LAN), a wide area network (WLAN), a Storage Area Network (SAN), etc., or a suitable combination thereof. The processor 150 may control access to the memory 104 by other components of the device 100 in addition to the peripheral interface 152.

Peripheral interface 152 couples input and output peripherals of device 100 to processor 150 and memory 104. The one or more processors 150 execute various software programs and/or sets of instructions stored in the memory 104 to perform various functions of the device 100 and process data. In some embodiments, peripheral interface 152 and processor 150 may be implemented on a single chip. And in some embodiments they may be implemented on multiple discrete chips.

The RF (radio frequency) circuit 120 receives and transmits electromagnetic waves. The RF circuit 120 converts electrical signals into electromagnetic waves or vice versa and communicates with a communication network and other communication devices via electromagnetic waves. The RF circuitry 120 may include well-known circuitry for performing these functions, including but not limited to an antenna system, an RF transceiver, one or more amplifiers, a tuner, one or more oscillators, a digital signal processor, a CODEC chipset, a Subscriber Identity Module (SIM) card, memory, and so forth. The RF circuitry 120 may communicate with networks and other devices via wireless communications, such as the World Wide Web (WWW), an intranet and/or a wireless network, such as a cellular telephone network, a wireless Local Area Network (LAN) and/or a Metropolitan Area Network (MAN). The wireless communication may use any of a variety of communication standards, protocols, and technologies, including, but not limited to, global system for mobile communications (GSM), enhanced Data GSM Environment (EDGE), wideband Code Division Multiple Access (WCDMA), code Division Multiple Access (CDMA), time Division Multiple Access (TDMA), bluetooth, wireless fidelity (WIFI) (e.g., ieee802.11 a/b/g/n), voice over internet protocol (VoIP), wi-MAX, protocols for email, instant messaging, and/or Short Message Service (SMS), or any other suitable communication protocol, including communication protocols not yet developed at the filing date herein.

The external port 122 provides a wired communication interface between the intravenous delivery device 100, other medical devices (e.g., dock, central station, monitor, etc.), or users (computers or other communication devices). In some embodiments, it may be a communication interface controlled by a CAN bus protocol, a communication interface controlled by a serial communication protocol (e.g., RS485, RS 232), or a Universal Serial Bus (USB). The external port 122 is adapted to couple to other devices or users either directly or indirectly via a network (e.g., the internet, LAN, etc.).

The audio circuit 124 and speaker 154 provide an audio interface between the user and the iv set 100. Audio circuitry 124 receives audio data from peripheral interface 152, converts the audio data to electrical signals, and transmits the electrical signals to speaker 154. The speaker 154 converts the electrical signals into sound waves that are perceivable to humans.

The monitoring circuitry 126 may include fault detection circuitry to indicate the status of one or more of the processors 150. The protection circuit 128 may include hardware protection devices (e.g., fuses, TVS diodes) for protecting the electrical safety of various components within the iv set 100.

The processor 150 drives a power device (not shown) of the iv set 100 via the power drive circuit 130 such that the power device controllably moves under the drive of the processor 150. And during the movement, one or more force transmission/conversion devices (such as gears or transmission shafts) drive a control object (such as a pump door, a liquid stop clamp or a peristaltic squeezing mechanism) to move. The power plant may be an electromagnetic device that converts or transmits electrical energy according to the laws of electromagnetic induction, such as a Permanent Magnet (PM) motor, a reactive (VR) motor, and a Hybrid (HB) motor. In some embodiments, the motor is driven by the processor/controller 150 to move a control object (e.g., a pump door, a liquid stop clip, or a pump sheet) of the apparatus 100, so that the control object achieves a preset movement state.

In some embodiments, the peristaltic compression mechanism includes a camshaft, a set of pump vanes, and a compression plate. The processor/controller 150 in the device 100 sends out a command such as a rotation speed or a position, and drives a power device (e.g., a motor) to operate according to a specified rotation speed and a specified rotation direction through the power driving circuit 130, and the power device drives a camshaft connected with the power device to rotate in a rotating process; in the rotating process of the camshaft, the pump blade group on the camshaft makes linear reciprocating motion, namely, the pump blades on the pump blade group make linear reciprocating motion in sequence. The pump sheet group and the extrusion plate are matched to extrude and release the outer wall of the infusion apparatus in a reciprocating manner in sequence to drive the liquid in the infusion tube to flow in a continuous and directional manner. A speed reducing mechanism can be arranged between the power equipment and the camshaft to ensure that the rotating speed of the pump sheet set is stable and uniform.

In some embodiments, the drop count sensor 132 may be used with a drip chamber of an infusion set to detect the drop flow rate in the drip chamber.

In some embodiments, one or more bubble sensors 134 are used to detect the presence and/or size of gas present within the infusion set. The bubble sensor 134 may be an ultrasonic sensor or an infrared sensor, etc.

In some embodiments, the pressure sensor 136 may respond to a pressure value of the measurand and convert the pressure value into an electrical signal for detection and send to the control platform 102. The pressure sensor may be a resistive strain gauge pressure sensor, a semiconductor strain gauge pressure sensor, a piezoresistive pressure sensor, an inductive pressure sensor, a capacitive pressure sensor, a resonant pressure sensor, a fiber optic pressure sensor, or a capacitive acceleration sensor. In some embodiments, the pressure sensor 136 may be used to detect the internal pressure of the infusion set or the external pressure of the infusion set. In some embodiments, the pressure sensor 136 may also be used to detect the presence of the object under test (e.g., infusion tube).

An input/output (I/O) system 108 provides an interface between input/output peripherals of the iv set 100 and a peripheral interface 152. The input/output peripherals may be a display system 160, position sensors 164, displacement sensors 166, light assemblies 168, and other input/control devices 162. The I/O system 108 may include a display controller 140, a position sensor controller 144, a displacement sensor controller 146, a light controller 148, and one or more input controllers 142. One or more controllers in the I/O system 108 receive/transmit electrical signals from/to input/output peripherals. Where one or more input controllers 142 receive/transmit electrical signals from/to other input/control devices 162. The other input/control devices 162 may include physical buttons (e.g., push buttons, rocker buttons, touch buttons, etc.), slider switches, joysticks, and the like. In some embodiments, other input/control devices 162 may include a physical button for emergency stop of infusion.

In some embodiments, display system 160 may include a display screen that provides an output interface between device 100 and the user, which displays electronic files onto the screen through a particular transmission device and reflects them to the human eye; the display screen may comprise a cathode ray tube display (CRT), a plasma display PDP or a liquid crystal display LCD, etc. In some embodiments, display system 160 may include a touch screen that provides an input/output interface between device 100 and a user; the touch screen may include a resistive screen, a surface acoustic wave screen, an infrared touch screen, an optical touch screen, a capacitive screen, a nano-film, or the like, which is an inductive display device that may receive an input signal such as a contact. Visual output, whether a display screen or a touch screen, may be displayed to a user. The visual output optionally includes graphics, text, charts, video, and combinations thereof. Some or all of the visual output may correspond to user interface objects, further details of which will be described herein. The position sensor 164 may sense the position of the measurand and convert the position to a detectable electrical signal and send the electrical signal to the control platform 102 via the I/O system 108. The position sensor can be a contact sensor which generates signals by contact and extrusion of two objects, such as a travel switch and a two-dimensional matrix position sensor; or a proximity sensor that generates a signal by a predetermined distance between two objects, such as an electromagnetic sensor, a photoelectric sensor, a differential transformer sensor, an eddy current sensor, a capacitor sensor, a reed switch, an ultrasonic sensor, or a hall sensor. The object to be measured can comprise an infusion apparatus, a pump door, a pump sheet, a liquid stopping clamp, a push rod and the like. In some embodiments, the position of the pump door may be detected using a hall position sensor. In some embodiments, an electro-optical position sensor may be used to detect the position of the pump blade. In some embodiments, an electro-optical position sensor may be used to detect whether the infusion set is set in a predetermined position. In some embodiments, an optoelectronic position sensor may be used to detect the position status of the clamping mechanism of the syringe. In some embodiments, the position of the clamping tube of the liquid stop clamp can be detected by using an optoelectronic position sensor.

The displacement sensor 166 may be responsive to a change in position of the object being measured relative to the reference position and convert the change in position to a detectable electrical signal and transmit the electrical signal to the control platform 102 via the I/O system 108. The displacement sensor 166 may be inductive, capacitive, ultrasonic, or hall. In some embodiments, a potentiometer may be used to monitor the change in position of the pump door. In some embodiments, a potentiometer may be used to monitor the change in position of the slide of the syringe pump.

The light assembly 168 may include a visual alert element for alerting the device 100 of an abnormal condition. The light assembly 168 is solely responsive to actuation of the processor 150; the light assembly 168 may also be correspondingly engaged with the speaker 154 in response to activation of the processor 150, such as a light that changes color or intensity with the tone, frequency, or duration of the warning sound. The light assembly 168 may include an indicator light or a fluid delivery fault condition warning light for components such as a power source, CPU, etc. The light assembly 168 may also include visual illumination elements for facilitating viewing of the configuration or assembly status of the device 100 in the event of poor ambient light.

The iv set 100 also includes a power system 106 for powering the various components. The power system 106 may include a power management system, one or more power sources (e.g., batteries or Alternating Current (AC)), a charging system, power failure detection circuitry, a power converter or inverter, a power status indicator (e.g., light emitting diode LED), and may also include any other components associated with power generation, management, and distribution.

In some embodiments, the software components include an operating system 170, a communication module (or set of instructions) 172, a device/global internal state (or set of instructions) 174, a text input module (or set of instructions) 176, and one or more applications (or set of instructions) 178. The operating system 170 (e.g., darwin, RTXC, LINUX, UNIX, OS, WINDOWS, etc. embedded operating systems) includes various software components and/or drivers for controlling and managing conventional system tasks (e.g., memory management, storage device control, or power management, etc.) as well as facilitating communication between various software and hardware components. The communications module 172 facilitates communication with other devices via one or more external ports 122, and it also includes various software components for processing data received by the RF circuitry 120 and/or the external ports 122. In some embodiments, memory 104 stores device/global internal state 174. In some embodiments, the memory 104 stores a text input module 176, the text input module 176 providing various software components for entering text in one or more applications. Specifically, it may be used to input a bubble alarm threshold value or the like. In some embodiments, the memory 104 stores at least one application 178, the application 178 including a bubble level setting 178-1, the bubble level setting 178-1 may include an interface providing a user to enter different bubble levels, by which the bubble alarm threshold of the device 100 may be adjusted to suit the needs of different usage scenarios.

In some embodiments, the iv set is an infusion pump, which is used with an infusion apparatus and performs infusion operations set by a user according to a fluid configured by the user, which may include pressure-increasing drugs, pressure-decreasing drugs, nutrient solutions (drugs), chemotherapeutics, analgesics, anti-cancer drugs, uterine contraction drugs, anticoagulation drugs, anesthetics, and blood products (drugs), and the infusion operations include infusion at a set infusion rate, infusion at a set infusion amount, and the like. Wherein the infusion pump at least comprises an infusion pump power device, an infusion channel, a bubble sensor, a processor, a memory, a peripheral device interface and a liquid stopping clip. The infusion pump power equipment at least comprises power equipment and a pump piece; the infusion channel is used for providing an accommodating space of an infusion set. The following describes the principle of bubble detection in an infusion pump, taking an ultrasonic sensor as an example of a bubble sensor.

The bubble sensor comprises a sensing signal transmitting end and a sensing signal receiving end which are uniformly distributed on an infusion channel and arranged along the side edge of an infusion apparatus. The sensing signal transmitting end sends ultrasonic waves to penetrate through the infusion apparatus, and the ultrasonic waves can generate physical phenomena such as reflection, refraction, transmission and the like when penetrating through interfaces of two different media. Because the acoustic impedance difference between liquid and air is large, ultrasonic waves can be reflected and refracted to a large extent when penetrating through the interface surface of the liquid and the air, and by utilizing the physical phenomenon, the processor receives the feedback signal of the sensing signal receiving end to obtain the output amplitude (output voltage) of the feedback signal, so that the energy attenuation of the ultrasonic waves is monitored, and whether bubbles exist in the infusion apparatus and the existence degree of the bubbles can be identified according to the energy attenuation degree of the ultrasonic waves.

Fig. 2A to 2D are schematic views showing the form of bubbles, wherein the existence degree of the bubbles can be roughly classified into three types: (i) large bubbles; (ii) micro-bubbles; (iii) The remaining droplets, in particular, can be seen in FIGS. 2A-2D. As shown in fig. 2A, when a large bubble occurs in the infusion apparatus 21 and the large bubble is in the detection range of the bubble sensor, a nearly complete air column or a complete air column 22 is formed in the detection range of the bubble sensor, and at this time, the ultrasonic wave is greatly attenuated, and the processor can identify the large bubble by monitoring the output amplitude of the feedback signal; the large bubble may be formed by a single bubble or by polymerization of a plurality of bubbles. As shown in fig. 2C-2D, when the micro-bubble occurs in the infusion set 21 and the micro-bubble 24/25 is in the detection range of the bubble sensor, a part of gas and a part of liquid exist in the detection range of the bubble sensor, the bubble can exist in the liquid freely, the ultrasonic wave has less attenuation relative to the large bubble due to the better penetrability of the ultrasonic wave to the liquid, and the processor can identify the micro-bubble by monitoring the output amplitude of the feedback signal. As shown in fig. 2B, when the relatively viscous liquid 23 is in an empty bottle, a part of the liquid is likely to remain on the tube wall of the infusion set 21, and the remaining liquid drops are in the detection range of the bubble sensor, a part of gas and a part of liquid are formed in the detection range of the bubble sensor, at this time, the ultrasonic wave is attenuated less than the large bubbles, and the processor can identify the remaining liquid drops by monitoring the output amplitude of the feedback signal.

Wherein, the processor can correspondingly execute different events according to different existing degrees of the bubbles. After the processor identifies that a large bubble exists in the infusion apparatus, the processor calculates the volume of the large bubble, compares the volume of the large bubble with a bubble alarm threshold (e.g., volume) preset in the memory, and if the volume of the large bubble is greater than or equal to the bubble alarm threshold, the processor controls the infusion pump to be in a liquid stop state, for example, fig. 3 is an alternative structural schematic diagram of the infusion pump provided by the embodiment of the present invention, as shown in fig. 3, the processor 37 may stop the power device 32 to stop the pump sheet 33, and the pump sheet 33 stops pressing the liquid in the infusion apparatus 31 to flow in the infusion direction 38; alternatively, the processor 37 may close the liquid stop clip 36, so that the liquid stop clip 36 clamps the tube wall of the infusion set 31, and the liquid in the infusion set 31 stops flowing in the infusion direction 38. The processor may also issue a notification message relating to the large bubble via the peripheral interface, for example, as shown in FIG. 1, the processor 150 may control the audio circuit 124 via the peripheral interface 152 to issue an alarm tone to indicate the presence of the large bubble; alternatively, the processor 150 may control the display controller 140 or the light controller 148 through the peripheral device interface 152 to display visual cue information relating to large bubbles on the display system 160 or the light assembly 168; alternatively, the processor 150 may send the prompting information relating to the large bubble to other medical devices (e.g., monitors, dock) via the external port 122 to display the visual prompting information relating to the large bubble on the display system/light assembly of the other medical devices; alternatively, the processor 150 may send prompt information relating to the large bubble to other medical devices (e.g., monitors, dock) via the external port 122 to sound an alarm tone at the audio circuitry of the other medical devices.

In addition, the processor counts the number of the large bubbles meeting the condition that the volume of the large bubbles is smaller than the bubble alarm threshold value, and the counting result is represented as the accumulated bubble quantity. When the accumulated bubble amount exceeds a preset limit, for example, as shown in fig. 1, the processor 150 may control the audio circuit 124 through the peripheral interface 152 to emit an alarm audio to prompt the accumulated bubble amount to exceed the limit; alternatively, the processor 150 may control the display controller 140 or the light controller 148 through the peripheral interface 152 to display visual cues on the display system 160 or the light assembly 168 that relate to the excess of accumulated bubble volume; alternatively, the processor 150 may send a prompt message to other medical devices (e.g., monitor, dock) via the external port 122 that relates to the excess of the accumulated bubble volume to display a visual prompt message on the display system/light assembly of the other medical devices that relates to the excess of the accumulated bubble volume; alternatively, the processor 150 may send a prompt message via the external port 122 that relates to the excess of the cumulative bubble volume to other medical devices (e.g., monitors, dock) to sound an alarm audio in the audio circuitry of the other medical devices.

When the accumulated bubble amount does not exceed the preset limit, the processor controls the infusion pump to be in the infusion state, for example, as shown in fig. 3, the processor 37 holds the power device 32 and drives the pump blade 33 to be in the motion state, and the pump blade 33 presses the liquid in the infusion apparatus 31 to flow in the infusion direction 38; meanwhile, as shown in fig. 1, the processor 150 controls the display controller 140 through the peripheral interface 152 to display the current accumulated bubble amount on the display system 160; alternatively, the processor 150 may send the current accumulated bubble amount to other medical devices (e.g., monitors, dock) through the external port 122 to display the current accumulated bubble amount on the display system/light assembly of the other medical devices.

When the processor recognizes the presence of the microbubbles in the infusion set, the processor controls the infusion pump to be in the infusion state, for example, as shown in fig. 3, the processor 37 holds the power device 32 and drives the pump blade 33 to move, and the pump blade 33 presses the liquid in the infusion set 31 to flow in the infusion direction 38.

When the processor recognizes the remaining liquid drop, the processor controls the infusion pump to be in a liquid stop state, for example, as shown in fig. 3, the processor 37 may stop the power device 32 to stop the pump blade 33, and the pump blade 33 stops pressing the liquid in the infusion set 31 to flow in the infusion direction 38; alternatively, the processor 37 may close the liquid stop clip 36, so that the liquid stop clip 36 clamps the tube wall of the infusion set 31, and the liquid in the infusion set 31 stops flowing in the infusion direction 38. The processor may also issue a prompt message related to the residual liquid droplet through the peripheral device interface, for example, the prompt message related to the residual liquid droplet may be understood as a prompt message related to an empty bottle, and in practical applications, the prompt message related to the residual liquid droplet may also be a prompt message related to a large bubble, that is, the prompt message related to the large bubble may be the same as the prompt message related to the residual liquid droplet, specifically, as shown in fig. 1, the processor 150 may control the audio circuit 124 through the peripheral device interface 152 to issue an alarm audio to prompt an empty bottle; alternatively, the processor 150 may control the display controller 140 or the light controller 148 via the peripheral interface 152 to display a visual cue of an empty bottle on the display system 160 or the light assembly 168; alternatively, the processor 150 may send the empty bottle notification to other medical devices (e.g., monitors, dock) via the external port 122 to display the empty bottle visual notification on the display system/light assembly of the other medical devices; alternatively, the processor 150 may send the empty bottle notification to other medical devices (e.g., monitors, dock) via the external port 122 to sound an alarm tone in the audio circuitry of the other medical devices.

In some embodiments, the infusion pump is preset with a first bubble threshold and a second bubble threshold in the memory, and fig. 4 is a schematic diagram illustrating an output amplitude variation of a feedback signal of the bubble sensor according to the present invention; as shown in fig. 4, wherein the magnitude (e.g., voltage value) of the first bubble threshold 42 is greater than the magnitude (e.g., voltage value) of the second bubble threshold 43. The first bubble threshold 42 and the second bubble threshold 43 are set in association with one or more of a brand of an infusion apparatus, a material of the infusion apparatus, a pipe diameter of the infusion apparatus, a type of infusion liquid, an altitude environment, and the like, for example, the first bubble threshold and the second bubble threshold in the memory may be set with a plurality of sets of numerical values, and the processor may call the associated first bubble threshold and the second bubble threshold for operation and use according to one or more of the brand of the infusion apparatus, the material, the pipe diameter, and the type of infusion liquid in the altitude environment.

In some embodiments, referring to fig. 5, fig. 5 is a schematic diagram of an operation method of an infusion pump according to an embodiment of the present invention, the operation method of the infusion pump is as follows:

and S101, acquiring a feedback signal of the bubble sensor.

The processor acquires a feedback signal of the sensing signal receiving end.

In one embodiment, as shown in fig. 3, the infusion pump 30 is provided with a bubble sensor 35, and the processor 37 of the infusion pump obtains a feedback signal from the sensing signal receiving end of the bubble sensor 35.

In one embodiment, the infusion pump is provided with two bubble sensors, and the processor of the infusion pump acquires a plurality of feedback signals of sensing signal receiving ends of the at least two bubble sensors. For example, fig. 6 shows an alternative configuration of an infusion pump according to an embodiment of the present invention, as shown in fig. 6, the infusion pump 60 is provided with a first bubble sensor 63 and a second bubble sensor 64, the first bubble sensor 63 and the second bubble sensor 64 are distributed side by side along the infusion direction 62, and the processor 65 respectively obtains feedback signals of sensing signal receiving ends of the first bubble sensor 63 and the second bubble sensor 64.

In one embodiment, the infusion pump is provided with one or two bubble sensors, and at least one back-up bubble sensor. For example, fig. 7 shows an alternative structure of an infusion pump according to an embodiment of the present invention, as shown in fig. 7, the infusion pump 70 is provided with a first bubble sensor 73, a second bubble sensor 74 and at least one spare bubble sensor 75, the first bubble sensor 73 and the second bubble sensor 74 are arranged side by side along the infusion direction 72, the processor 76 obtains feedback signals from sensing signal receiving ends of the first bubble sensor 73 and the second bubble sensor 74, respectively, the processor 76 may also activate/activate the spare bubble sensor 75 according to a scene requirement (for example, when the first bubble sensor 73 and/or the second bubble sensor 74 fails), and after the spare bubble sensor 75 is activated, the processor 76 may also obtain a feedback signal from a sensing signal receiving end of the spare bubble sensor 75.

In some of these embodiments, the infusion pump is provided with at least one bubble sensor. Wherein at least two of the at least one bubble sensors emit sensing signals having different emission frequencies. For example, fig. 8 is a schematic diagram of feedback signals of different frequencies of the bubble sensor in the present invention, and as shown in fig. 8, according to the instruction of the processor, the ultrasonic signal emitted by the bubble sensor is frequency-modulated, so that the bubble sensor emits ultrasonic waves with a frequency f1 in a first time period t1, the bubble sensor emits ultrasonic waves with a frequency f2 in a second time period t2, and the bubble sensor emits ultrasonic waves with a frequency f3 in a third time period t 3. Alternatively, at least two bubble sensors in the infusion pump each emit a sensing signal in an emission mode, and the signal frequency of each sensing signal is different, for example, according to the instruction of the processor, the ultrasonic signal emitted by the first bubble sensor is frequency-modulated, so that the first bubble sensor emits ultrasonic waves with the frequency f1 in the first time period t1, and the second bubble sensor emits ultrasonic waves with the frequency f2 in the first time period t 1. Or, at least two bubble sensors in the infusion pump respectively emit at least one sensing signal, and the signal frequency of each sensing signal is different, for example, the first bubble sensor is made to emit ultrasonic waves with the frequency f1 in the first time period t1, the first bubble sensor is made to emit ultrasonic waves with the frequency f2 in the second time period t2, and the first bubble sensor is made to emit ultrasonic waves with the frequency f3 in the third time period t 3; and performing frequency modulation on an ultrasonic signal emitted by the second bubble sensor, so that the second bubble sensor emits ultrasonic waves with the frequency f1 in a first time period t1, the second bubble sensor emits ultrasonic waves with the frequency f2 in a second time period t2, and the second bubble sensor emits ultrasonic waves with the frequency f3 in a third time period t 3.

Based on the above arrangement, the processor may obtain the feedback signals fed back by the at least one bubble sensor based on the emission signals with different frequencies, and perform correlation function processing, such as extremum, average, integral summation, etc., on the output amplitudes of the plurality of feedback signals of the at least one bubble sensor in the same time period to obtain the output amplitude of the target feedback signal. For example, the first bubble sensor emits ultrasonic waves with the frequency of f1 in the first time period t1, the second bubble sensor emits ultrasonic waves with the frequency of f2 in the first time period t1, the third bubble sensor emits ultrasonic waves with the frequency of f3 in the first time period t1, the processor can calculate the average value of feedback signals fed back by the ultrasonic waves based on the f1, the f2 and the f3 according to the feedback signals of the processors in the first time period t1 to serve as a target feedback signal, and then process subsequent steps according to the output amplitude of the target feedback signal, so that the method is beneficial to overcoming the discreteness influence of the bubble sensors, reducing the saturation probability of circuit signals, improving the compatibility of infusion set pipes with different thicknesses, reducing the influence caused by tubing set deviation of the infusion set to a certain extent, and improving the accuracy and reliability of overall bubble detection.

Based on the above arrangement, the processor may also obtain a feedback signal fed back by the at least one bubble sensor based on the emission signals with different frequencies, and select a target feedback signal from a plurality of reflection signals based on different frequencies of each bubble sensor, where an output amplitude of the target feedback signal is closest to the preset amplitude typical value. For example, the time period t includes t1, t2, and t3 in sequence, the first bubble sensor emits an ultrasonic wave with a frequency f1 in the first time period t1, emits an ultrasonic wave with a frequency f2 in the second time period t2, and emits an ultrasonic wave with a frequency f3 in the third time period t3, and assuming that the output amplitude of the feedback signal fed back by the ultrasonic wave with the frequency f2 is closest to the preset amplitude typical value, the processor takes the feedback signal fed back by the ultrasonic wave with the frequency f2 as the target feedback signal of the time period t, and then performs subsequent bubble detection processing on the target feedback signal. The amplitude representative value is calculated statistically from a large amount of data of the bubble sensor. The processor can perform subsequent processing after obtaining the output amplitude of the target feedback signal of each bubble sensor.

In one embodiment, the processor may control the bubble sensor to emit at a frequency of 0 for one of the time periods. For example, the state of the t4 period in fig. 8. The processor can test the performance of the bubble sensor of the infusion pump according to the feedback signal when the emission frequency is 0 so as to judge whether the bubble sensor is in a normal working state; if the emission frequency of the bubble sensor is 0 and the output amplitude of the corresponding feedback signal is 0, the processor can determine that the bubble sensor is in a normal working state; if the emission frequency of the bubble sensor is 0 and the output amplitude of the corresponding feedback signal is not 0, the processor may determine that the bubble sensor is in an abnormal operation state. Similarly, the processor can also control the emission frequency of one time period of the bubble sensor to be far lower than the conventional emission frequency of the bubble sensor, and can also judge the abnormal working state of the bubble sensor.

In one embodiment, the processor may control the emission frequency of one of the bubble sensors to be the resonance frequency of the bubble sensor. The multiple transmission frequencies of one of the bubble sensors can also be controlled to be close to the resonance frequency of the bubble sensor. Therefore, the method is favorable for acquiring feedback signals with proper output amplitudes (without over-low or over-saturation) and also favorable for the accuracy of subsequent bubble judgment.

In the above embodiment, the processor determines the target feedback signal, so that the processor may be interfered by discreteness of different bubble sensors as much as possible in the process of avoiding bubble determination, and the saturation probability of the circuit signal may also be reduced, thereby avoiding missing bubbles; the compatibility of infusion apparatus pipes with different thicknesses can be improved, the influence of infusion apparatus pipe installation deviation on the bubble judgment process is reduced to a certain extent, and the accuracy and the reliability of subsequent bubble detection are improved.

S103, determining the existence degree of bubbles in the infusion apparatus according to the feedback signal;

the degree of presence of the bubbles includes three types: (i) large bubbles; (ii) micro-bubbles; (iii) residual droplets.

The feedback signal referred to herein may be a feedback signal directly received by the bubble sensor, or may be a target feedback signal acquired by the processor in the above embodiment.

In one embodiment, the processor obtains a feedback signal of a bubble sensor, and after receiving the feedback signal, the processor compares the output amplitude of the feedback signal with the first bubble threshold and the second bubble threshold. When the output amplitude of the feedback signal is less than the second bubble threshold value, the ultrasonic wave is attenuated greatly, and the large bubble in the infusion set can be determined. When the output amplitude of the feedback signal is larger than the first bubble threshold value, the ultrasonic wave is only slightly attenuated, and the existence of tiny bubbles or even no bubbles in the infusion set can be determined. When the output amplitude of the first bubble threshold value is larger than or equal to the second bubble threshold value, the ultrasonic wave is attenuated to a medium degree, and micro bubbles or residual liquid drops exist.

In one embodiment, fig. 9 shows an alternative structure of the infusion pump according to the embodiment of the present invention, as shown in fig. 9, the bubble sensor 95 is disposed between the pump sheet 93 and the liquid stop clip 96, and the liquid stop clip 96 is connected to the motor 97 of the liquid stop clip, and the opening or closing of the liquid stop clip 96 can be driven by the processor 98 controlling the motor 97 of the liquid stop clip. The processor 98 obtains a feedback signal from the bubble sensor 95, and the processor 98 compares the output amplitude of the feedback signal with the first bubble threshold and the second bubble threshold after receiving the feedback signal. When the output amplitude of the feedback signal is less than the second bubble threshold, it indicates that the ultrasonic wave is attenuated relatively greatly, and it can be determined that a large bubble exists in the infusion set 91. When the output amplitude of the feedback signal is greater than the first bubble threshold, it indicates that the ultrasonic wave is only slightly attenuated, and it can be determined that there are micro-bubbles or even no bubbles in the infusion set 91. When the first bubble threshold is greater than or equal to the second bubble threshold, which indicates that the ultrasonic wave is attenuated to a medium degree, the processor 98 may recognize that there is a micro bubble or a residual liquid droplet, and at this time, the infusion pump 90 may switch to the first operation mode, and the processor 98 may perform the following operations to accurately determine whether the micro bubble or the residual liquid droplet, specifically as follows:

the processor 98 closes the liquid stop clip 96 by driving the motor 97 of the liquid stop clip, so that the liquid stop clip 96 clips the tube wall of the infusion set 91. And during the period that the liquid stopping clamp 96 is closed, the processor 98 drives the pump plate 93 to move for a preset time by driving the power device 92 of the infusion pump (for example, the pump plate 93 is driven to move so as to drive infusion liquid drops to flow in the opposite direction of infusion), so that the diameter of the infusion apparatus 91 is deformed (for example, the diameter of the infusion apparatus 91 is reduced), or the processor may monitor the pressure change of the infusion apparatus 91 by arranging a pressure sensor (not shown), and monitor that during the period that the liquid stopping clamp 96 is closed, the processor 98 drives the pump plate 93 to move for a preset time by driving the power device 92 of the infusion pump so that the pressure in the infusion apparatus 91 is changed. The processor 98 obtains the feedback signal through the bubble sensor 95 after the deformation or the pressure in the infusion apparatus 91 changes, and if the output amplitude of the feedback signal at this time is greatly reduced sharply; then the processor 98 drives the pump sheet to preset another preset time in the opposite direction by driving the power device of the infusion pump (for example, the processor drives the pump sheet to move so as to drive the infusion liquid drops to flow in the infusion direction), so that the diameter of the infusion apparatus can be recovered to the original shape; or the pressure sensor monitors that the pressure in the infusion set 91 is restored, the processor 98 obtains the feedback signal of the bubble sensor 95 at this time, and determines that the output amplitude of the feedback signal is kept at the initial state (for example, greater than the first bubble threshold). The processor 98 may determine that the micro-bubble exists at this time according to the trend of the feedback signal returning to the original state after dropping suddenly, because the micro-bubble changes into a complete air column after the transfusion apparatus 91 deforms or the pressure increases, for example, after the pipe diameter shrinks, the ultrasonic wave of the bubble sensor 95 is attenuated greatly through the complete air column to cause the output amplitude of the feedback signal to drop suddenly greatly, and then the pressure and/or the diameter in the transfusion apparatus 91 return to the original state, so the output amplitude of the feedback signal returns to the original state. If the output amplitude of the feedback signal does not change significantly, the processor 98 can determine that there is a residual droplet and the volume of the residual droplet is small, and the residual droplet is not affected by the diameter deformation of the infusion set, so that the output amplitude of the feedback signal of the bubble sensor 95 does not change significantly. If the output amplitude of the feedback signal at this time is greatly and steeply increased and then greatly and steeply decreased, the processor may determine that there is a residual liquid droplet (for example, a liquid droplet with a larger volume or a plurality of liquid droplets with a smaller volume) at this time, because the residual liquid droplet may be affected by the diameter deformation of the infusion apparatus 91 to form a complete liquid column, when the liquid column passes through the detection range of the bubble sensor 95 under the extrusion of the pump plate 93, the ultrasonic wave of the bubble sensor 95 may be attenuated little through the complete liquid column to cause the output amplitude of the feedback signal to be greatly and steeply increased, and when the liquid column leaves the detection range of the bubble sensor under the extrusion of the pump plate, the ultrasonic wave of the bubble sensor may be attenuated greatly at a pause to cause the output amplitude of the feedback signal to be greatly and steeply decreased. If the output amplitude of the feedback signal at this time drops steeply and then stays below the large bubble threshold, the processor 98 may also determine that there is a residual liquid droplet (e.g., a liquid droplet with a larger volume or a plurality of liquid droplets with smaller volumes) at this time, because the residual liquid droplet is affected by the diameter deformation or the pressure change of the infusion set 91, and forms a complete liquid column in the detection range of the bubble sensor 95, and when the liquid column leaves the detection range of the bubble sensor 95 under the extrusion of the pump plate 93, the ultrasonic wave of the bubble sensor 95 attenuates greatly at a pause to cause the output amplitude of the feedback signal to drop steeply, and then the output amplitude stays below the large bubble threshold.

In one embodiment, as shown in FIG. 6, the processor 65 obtains a first feedback signal from the first bubble sensor 63 and obtains a second feedback signal from the second bubble sensor 64; specifically, in various embodiments of the present invention, the degree of bubbles in the infusion set is determined based on the signal attenuation degree of the first bubble sensor 63 and the second bubble sensor 64 at the overlapping portion of the first acquisition time and the second acquisition time. The processor 65 compares the first feedback signal of the first bubble sensor 63 with the first bubble threshold value and the second bubble threshold value, and the processor 65 compares the second feedback signal of the second bubble sensor 64 with the first bubble threshold value and the second bubble threshold value. When the output amplitude of the first feedback signal or the second feedback signal is less than the second bubble threshold, it indicates that the ultrasonic wave is attenuated relatively greatly, and it can be determined that a large bubble exists in the infusion set 61. When the output amplitude of the first feedback signal or the second feedback signal is greater than the first bubble threshold, it indicates that the ultrasonic wave is only slightly attenuated, and it can be determined that there are micro-bubbles or even no bubbles in the infusion set 61. When the first bubble threshold is greater than or equal to the output amplitude of the first feedback signal and greater than or equal to the second bubble threshold, and the first bubble threshold is greater than or equal to the output amplitude of the second feedback signal and greater than or equal to the second bubble threshold, the processor 65 may determine that the micro bubbles or the residual liquid droplets exist.

In some embodiments of the present invention, the processor 65 may further obtain a time when the first feedback signal of the first bubble sensor 63 starts to be lower than the second bubble threshold value, and obtain a time when the second feedback signal of the second bubble sensor 64 starts to be lower than the second bubble threshold value, and calculate a current flow rate of the infusion pump according to a time difference between the two times, which may also be understood as a shortest time when the first bubble sensor 63 and the second bubble sensor 64 are in close proximity to an event that the feedback signal is lower than the second bubble threshold value. From this time difference and knowing the distance between the first bubble sensor 63 and the second bubble sensor 64 in advance, the current flow rate of the infusion pump can be obtained. The current flow rate may be used to calibrate a set flow rate of the infusion pump, or for other infusion parameter statistics, etc.

At this time, the processor 65 may perform the following operations to accurately determine whether the droplet is a micro-bubble or a residual droplet, specifically as follows:

the processor 65 also stores the feedback signal as feedback history information while acquiring the feedback signal. The processor obtains a first feedback time by calling the feedback history information in the memory, where the first feedback time is used to represent a time point when the output amplitude of the feedback signal of the first bubble sensor 63 starts to enter a first bubble threshold and a second bubble threshold interval (that is, a judgment condition that the first bubble threshold is greater than or equal to the output amplitude of the feedback signal of the first bubble sensor is greater than or equal to the second bubble threshold is met). The processor 65 further obtains a time point when the output amplitude of the feedback signal of the second bubble sensor 64 in the feedback history information of the second bubble sensor 64 starts to enter a range between the first bubble threshold and the second bubble threshold (i.e. meets a judgment condition that the output amplitude of the feedback signal of the second bubble sensor is greater than or equal to the first bubble threshold). The processor 65 determines whether the first feedback time and the second feedback time have a precedence relationship; if there is a precedence relationship and the time difference T between the two satisfies the preset time value, the processor 65 may determine that there is a residual droplet. If no precedence relationship exists, the processor 65 may determine that a micro-bubble exists. This is because when the fine bubbles accumulate in the detection range of the bubble sensor, the decay time of the feedback signal is random and not sequential. If the liquid drops are remained, the liquid staying on the pipe wall can be sequentially present in the detection range of the first bubble sensor and the second bubble sensor under the extrusion of the pump sheet, so that the attenuation of the feedback signals of the first bubble sensor and the second bubble sensor is caused. The preset time value is related to the tube diameter of the infusion set, the infusion flow rate, and the distance between the first bubble sensor 63 and the second bubble sensor 64. The preset time value can be determined according to the tube diameter of the infusion set 61, the infusion flow rate and the distance between the first bubble sensor 63 and the second bubble sensor 64.

The other mode is specifically as follows: the first bubble sensor and the second bubble sensor of the embodiment are arranged between the pump sheet and the liquid stopping clamp, the liquid stopping clamp is connected with the motor of the liquid stopping clamp, and the opening or closing of the liquid stopping clamp can be driven through the control of the processor on the motor of the liquid stopping clamp. At this time, the infusion pump may be switched to the first operation mode, and the processor may perform the following operations to accurately determine whether the liquid droplet is a micro-bubble or a residual liquid droplet, as follows:

the processor closes the liquid stopping clamp by driving a motor of the liquid stopping clamp, so that the liquid stopping clamp clamps the tube wall of the infusion apparatus. And during the period that the liquid stopping clamp is closed, the processor drives the pump sheet to move for a preset time through the power equipment for driving the infusion pump (for example, the power equipment drives the pump sheet to move so as to drive infusion liquid drops to flow in the opposite direction of infusion), so that the diameter of the infusion apparatus is deformed (for example, the diameter of the infusion apparatus is reduced), or the processor can monitor the pressure change of the infusion apparatus through the pressure sensor, and monitor that during the period that the liquid stopping clamp is closed, the processor drives the pump sheet to move for a preset time through the power equipment for driving the infusion pump so that the pressure in the infusion apparatus is changed. The processor obtains a feedback signal through the first or second bubble sensor after the diameter of the infusion apparatus is deformed or the pressure in the infusion apparatus is changed, and if the output amplitude of the feedback signal is greatly and steeply reduced at the moment; then the processor drives the pump sheet to preset another preset time in the opposite direction through driving the power device of the infusion pump (for example, the pump sheet is driven to move so as to drive infusion liquid drops to flow in the infusion direction), so that the diameter of the infusion set can be recovered, or the pressure sensor monitors the pressure in the infusion set to be recovered, the processor obtains a feedback signal of the first bubble sensor or the second bubble sensor at the moment, and determines that the output amplitude of the feedback signal is kept in an initial state (for example, greater than a first bubble threshold value). The processor can determine that the micro-bubbles exist at the moment according to the trend that the feedback signal is suddenly reduced and then restored, because the micro-bubbles can be changed into a complete air column after the infusion apparatus is deformed, for example, the pipe diameter is contracted, the ultrasonic waves of the bubble sensor can be greatly attenuated through the complete air column to cause the output amplitude of the feedback signal to be greatly and suddenly reduced, then the pressure in the infusion apparatus is restored to the original state, the diameter is restored to the original state, and then the output amplitude of the feedback signal can be restored to the original state. If the output amplitude of the feedback signal at this time does not change obviously, the processor can determine that a residual liquid drop exists at this time and the volume of the residual liquid drop is small, and because the residual liquid drop is not influenced by the diameter deformation of the infusion apparatus, the output amplitude of the feedback signal of the first bubble sensor or the second bubble sensor does not change obviously. If the output amplitude of the feedback signal of the first bubble sensor rises steeply and drops steeply after the first bubble sensor rises steeply greatly, and the output amplitude of the feedback signal of the second bubble sensor also rises steeply and drops steeply after the second bubble sensor rises steeply and drops steeply, the processor can determine that residual liquid drops (such as liquid drops with larger volume or aggregation of a plurality of liquid drops with smaller volume) exist at the moment, because the residual liquid drops can be influenced by the diameter deformation of the infusion apparatus, a complete liquid column is formed, when the liquid column passes through the detection range of the first bubble sensor under the extrusion of the pump sheet, the ultrasonic wave of the first bubble sensor is attenuated little through the complete liquid column to cause the steep rise of the output amplitude of the feedback signal, and when the liquid column passes through the detection range of the second bubble sensor, the ultrasonic wave of the second bubble sensor is attenuated little through the complete liquid column to cause the steep rise of the output amplitude of the feedback signal; after that, when the liquid column is squeezed by the pump sheet and leaves the detection range of the second bubble sensor, the ultrasonic wave of the second bubble sensor is greatly attenuated, so that the output amplitude of the feedback signal is greatly and steeply reduced. If the output amplitudes of the feedback signals of the first bubble sensor and the second bubble sensor drop steeply and then stay below the second bubble threshold value, the processor can also determine that residual liquid drops (for example, liquid drops with larger volume or aggregation of a plurality of liquid drops with smaller volume) exist at the moment, because the residual liquid drops are influenced by the diameter deformation of the infusion apparatus, and form a complete liquid column in the detection range of the bubble sensor, when the liquid column is extruded by the pump sheet and leaves the detection range of the first bubble sensor or the second bubble sensor, the ultrasonic pause of the first bubble sensor or the second bubble sensor is greatly attenuated to cause the output amplitude of the feedback signals to drop greatly, and then the output amplitude stays below the second bubble threshold value.

And S105, executing an event corresponding to the existence degree of the air bubbles according to the existence degree of the air bubbles.

The processor keeps the liquid stopping state and sends out prompt information related to large bubbles or keeps the transfusion state and updates the accumulated bubble amount when the processor identifies that the large bubbles exist in the transfusion device according to the three comparative results; when the tiny bubbles in the infusion apparatus are identified, the infusion state is kept; when the micro-bubbles or residual liquid drops possibly existing in the infusion apparatus are identified, the liquid stopping state is kept, and prompt information of the residual liquid drops is sent out, or the infusion state is kept; and when the existence of the residual liquid drops is recognized, keeping the liquid stopping state and sending out prompt information of the residual liquid drops.

In one embodiment, after the processor identifies the presence of a large bubble, it may then follow the following equation:

V＝v×d×t (1)

v is the volume of the large bubbles; v is the flow rate per unit time of the infusion set, which is generally set by the user according to the order; d is the diameter of the infusion apparatus; t is the time for the large bubble to pass through the detection range of the bubble sensor.

After the processor obtains the volume of the large bubbles according to the mode, the volume of the large bubbles is compared with a preset bubble alarm threshold (such as a bubble alarm volume), and if the volume of the large bubbles is larger than or equal to the preset bubble alarm threshold, the processor keeps a liquid stopping state and sends out prompt information related to the large bubbles; if the volume of the large bubble is less than the preset bubble alarm threshold, the processor keeps the infusion state and updates the value of the accumulated bubble in the memory (for example, the value of the accumulated bubble is increased by 1).

In one embodiment, a bubble sensor is disposed within the infusion pump; the infusion pump operating method described above can be applied to the infusion pump of this embodiment. The embodiment can further refine the existing degree of the bubbles through setting the two bubble thresholds, so that the possible occurrence condition of the residual liquid drops can be identified only through the bubble detection process of the bubble sensor, and other devices and additional processes are not needed. The infusion pump can remind or operate more accurately according to more accurate bubble existence degree, the safety is high, and user experience is good.

Fig. 10 is a flowchart of determining the existence degree of air bubbles by using the infusion pump according to the embodiment of the present invention, wherein the used infusion pump has a structure as shown in any one of the foregoing embodiments, and the sensing signal receiving end is configured to receive a feedback signal attenuated by the sensing signal passing through the infusion set; the method comprises the following steps:

s1001: the processor detects that the feedback signal descends, enters a bubble identification state and triggers the infusion pump to enter a second working mode;

when the output amplitude of the feedback signal changes to a value between a first bubble threshold and a second bubble threshold, the processor judges that micro bubbles or residual liquid drops exist in the infusion apparatus, specifically, the micro bubbles generated in the infusion process of liquid in the infusion apparatus may be clamped at a bubble sensor, so that the feedback signal is reduced, the processor judges the occurring micro bubbles as large bubbles, so that frequent false alarm is caused, and the infusion pump stops working. Correspondingly, the air bubbles in the infusion apparatus may be in a non-semi-aqueous semi-gaseous state, and specifically, the non-semi-aqueous semi-gaseous state includes at least one of the following states: no bubble is in the infusion apparatus, the volume of the bubble in the infusion apparatus does not reach the micro bubble, the bubble in the infusion apparatus is the micro bubble, and the bubble in the infusion apparatus is the big bubble; the infusion pump can identify the semi-aqueous semi-gas state through the first working mode, and can identify the non-semi-aqueous semi-gas state through the second working mode.

S1002: judging whether the bubbles in the current infusion set are smaller than a first bubble threshold value, if so, executing S1004, otherwise, executing S1003;

s1003: maintaining the infusion state of the infusion pump;

wherein, the bubble threshold value includes first bubble threshold value and second bubble threshold value, just first bubble threshold value is greater than the second bubble threshold value, when the output amplitude of the feedback signal who detects is not less than first bubble threshold value, it does not reach the microbubble yet to show that the microbubble begins to appear in the transfusion system or the volume of the bubble that appears has not yet reached, even do not have the bubble, also do not cause the influence to infusion safety, the infusion state of transfer pump is kept this moment, can avoid the transfusion system only appear when some microbubble that is not enough to influence patient's safety, the transfer pump is with frequent alarm, even stop working, influence the continuous infusion of transfer pump.

S1004: judging whether the bubbles in the current infusion set are smaller than a second bubble threshold value, if so, executing S1005, otherwise, executing S1008;

s1005: calculating the volume of the large bubbles in the infusion apparatus;

in some embodiments, when the output amplitude of the detected feedback signal is smaller than the second bubble threshold, it indicates that a large bubble occurs in the infusion set, wherein the large bubble in the infusion set may be formed by a single bubble or by aggregation of multiple bubbles; because the infusion pumps are not equipped with the same liquid medicine, the corresponding alarm gears of the infusion sets in different use environments are not completely the same, and certainly, the volumes of the large bubbles which trigger the infusion pumps to stop working are different corresponding to different alarm gears. Specifically, in calculating the large bubble volume, the processor may calculate the volume of the large bubble according to the formula:

V ₁ ＝v ₁ ×d ₁ ×t ₁ (2)

V ₁ is the volume of the large bubble; v. of ₁ The flow rate of the infusion apparatus in unit time at the current alarm gear can be set according to medical advice; d ₁ The diameter of the infusion set; t is t ₁ The output amplitude of the feedback signal is below the second bubble threshold time.

S1006: judging whether the volume of the bubbles is larger than a corresponding alarm gear according to the calculation result of the volume of the bubbles, if so, executing S1011, otherwise, executing S1007;

s1007: calculating the calculation result of the volume of the bubbles into the accumulated bubble amount;

in one embodiment of the invention, different alarm gears of the infusion apparatus correspond to different bubble alarm thresholds, and when the calculated volume of the large bubble does not exceed the preset bubble alarm threshold, the processor maintains the infusion state of the infusion pump through a corresponding control instruction and updates the accumulated bubble amount in the memory; further, when the accumulated bubble amount exceeds the preset limit, the processor can stop the operation of the infusion pump through a corresponding control instruction and output corresponding prompt information related to the exceeding of the accumulated bubble amount.

S1008: triggering the infusion pump to enter a first working mode so as to identify the semi-water and semi-gas state;

when the output amplitude of the feedback signal changes to a value between a first bubble threshold value and a second bubble threshold value, bubbles in the infusion apparatus are in a semi-water and semi-gas state, and the state of the bubbles cannot be determined simply through the change of the output amplitude of the feedback signal because the bubbles are clamped at the bubble sensor or the residual liquid drops appear as the output amplitude of the feedback signal changes to a value between the first bubble threshold value and the second bubble threshold value and remain unchanged, so that the infusion pump needs to be triggered to enter a first working mode to accurately judge whether the bubbles or the residual liquid drops appear in the infusion apparatus, and the identification of the semi-water and semi-gas state is realized.

S1009: and judging whether residual liquid drops appear, if so, executing S1011, otherwise, executing S1010.

In an embodiment of the present invention, the processor is configured to obtain a feedback signal during a period when the pump blade drives a liquid in the infusion apparatus to move, and determine the execution event according to the feedback signal, specifically, when the infusion pump enters a first operation mode, a liquid stop clip of the infusion pump is in a liquid stop state and the pump blade is in a moving state, and when the liquid stop clip is in the liquid stop state, the pump blade may drive the liquid in the infusion apparatus to move toward a direction opposite to the infusion direction, or the pump blade drives the liquid in the infusion apparatus to move toward a direction opposite to the infusion direction, as shown in fig. 10A, during this process, the liquid in the infusion apparatus moves sufficiently, and a small bubble clamped at the bubble sensor in the infusion apparatus polymerizes due to the fluidity of the liquid and radial shrinkage of the infusion tube to form a large bubble or a complete air column, and when the pressure in the infusion apparatus returns to the initial state, the formed large bubble or complete air column is again turned into a small bubble in the initial state, and accordingly, during the change of this form of the small bubble, the output amplitude of the feedback signal of the bubble sensor is decreased from the second threshold value between the second threshold value and the second threshold value, and the pressure of the small bubble returns to the second threshold value, and the second threshold value is again decreased to the second threshold value; therefore, the situation that micro-bubbles exist in the infusion apparatus and can be at the position of the bubble sensor but do not affect the infusion is explained, so that the processor can keep the infusion pump in the infusion state in the first operation mode through corresponding control instructions.

In an embodiment of the present invention, when the infusion pump enters the first operation mode, the liquid stop clip of the infusion pump is in a liquid stop state and the pump blade is in a motion state, and when the liquid stop clip is in the liquid stop state, the pump blade may drive the liquid in the infusion apparatus to move toward the opposite direction of the infusion, or the pump blade drives the liquid in the infusion apparatus to move toward the opposite direction of the infusion and then move toward the infusion direction, as shown in fig. 10B, in this process, the liquid in the infusion apparatus moves sufficiently, and a single residual liquid droplet in the infusion apparatus does not change in form due to the radial change of the infusion apparatus, so the output amplitude of the feedback signal of the bubble sensor remains between the first bubble threshold and the second bubble threshold. Further, when the number of the residual liquid drops in the infusion apparatus is multiple, as shown in fig. 10C, in the process that the liquid stopping clip is in the liquid stopping state and the pump blade is in the moving state, due to the radial change of the infusion apparatus, the multiple residual liquid drops form a complete liquid column, when the liquid column passes through the bubble sensor, the output amplitude of the feedback signal of the bubble sensor is greatly and steeply increased, and when the liquid column leaves the same bubble sensor, the output amplitude of the feedback signal of the bubble sensor is greatly and steeply decreased, thereby indicating that the residual liquid drops appear in the infusion apparatus, the processor can keep the liquid stopping state of the infusion pump through a corresponding control instruction in the first working mode and send out the prompt information of the residual liquid drops so as to prompt medical staff to timely process the appeared residual liquid drops.

Further, when the number of the residual liquid drops in the infusion apparatus is multiple, and in the process that the liquid stopping clip is in the liquid stopping state and the pump blade is in the moving state, due to radial change of the infusion apparatus, the multiple residual liquid drops form a complete liquid column, the formed complete liquid column moves in position in the infusion apparatus, the liquid column is squeezed by the pump blade and leaves the detection range of the bubble sensor, the output amplitude of the feedback signal of the corresponding bubble sensor is greatly reduced from the value between the first bubble threshold value and the second bubble threshold value and is kept lower than the second bubble threshold value, therefore, the processor can also judge that the residual liquid drops appear in the infusion apparatus, and the processor can keep the liquid stopping state of the infusion pump and send out prompt information of the residual liquid drops through corresponding control instructions in the first working mode so as to prompt medical staff to timely process the appearing residual liquid drops.

In some embodiments of the invention, the infusion pump is configured with a pressure sensor, and the pressure sensor can be used for monitoring the pressure in the infusion apparatus in real time, so as to avoid the situation that the tube wall of the infusion apparatus is broken due to the pressure in the infusion apparatus, and the infusion safety is influenced.

In some embodiments of the present invention, the processor may determine, through the pressure sensor configured in the infusion pump, a movement direction and a movement period of the liquid in the infusion apparatus driven by the pump sheet according to the monitored pressure in the infusion apparatus, and drive the pump sheet to move according to the movement direction and the movement period of the liquid in the infusion apparatus driven by the pump sheet, specifically, when it is determined that the flow direction of the liquid in the infusion apparatus is the infusion direction through the monitored pressure in the infusion apparatus, the processor may control, through a control instruction, the pump sheet to drive the liquid in the infusion apparatus to move toward the opposite direction of the infusion, or control, through the control instruction, the pump sheet to drive the liquid in the infusion apparatus to move toward the infusion direction after moving toward the opposite direction of the infusion, so that when the infusion pump is in the first operating mode, the liquid stop clamp of the infusion pump is in a liquid stop state, and the liquid in the infusion apparatus is driven by the pump sheet to fully move.

Further, the processor of the infusion pump can also acquire a feedback signal during the movement of the liquid in the infusion apparatus driven by the pump sheet and the pressure during the movement of the liquid in the infusion apparatus driven by the pump sheet, wherein the feedback signal during the movement generates amplitude reduction when the pressure parameter rises, and when the pressure parameter returns to the initial pressure parameter and also returns to the initial amplitude, the execution event is determined according to the feedback signal during the movement and the pressure during the movement; the execution event is that the liquid stopping clamp is in an opening state and the pump sheet is in a motion state. Specifically, when the transfer pump entered into the first operating mode, the liquid stopping clip was in the liquid stopping state, the pump sheet can drive the liquid in the transfusion system to move towards the transfusion opposite direction, or the pump sheet drives the liquid in the transfusion system to move towards the transfusion opposite direction after moving towards the transfusion opposite direction, the pressure in the transfusion system was also changing in this process, the treater of transfer pump was when obtaining the pressure value in the transfusion system that constantly changes, also was obtaining the feedback signal of bubble sensor, if at this in-process, the bubble existence degree in the transfusion system is the microbubble, so along with the liquid full motion in the transfusion system, the microbubble that blocks in bubble sensor department in the transfusion system can polymerize owing to the mobility of liquid and the radial shrinkage of transfer line, form big bubble or complete gas column. When the form of the infusion apparatus is recovered to the initial state along with the continuous movement of the pump sheet, the pressure in the infusion apparatus is also recovered to the initial state, the formed large bubbles or the complete air column are converted into the micro bubbles in the initial state again, correspondingly, in the change process of the form of the micro bubbles, along with the pressure change in the infusion apparatus monitored by the pressure sensor, the output amplitude of the feedback signal of the bubble sensor is greatly and sharply reduced to be lower than a second bubble threshold value from the range between the first bubble threshold value and the second bubble threshold value of the initial state, and when the pressure in the infusion apparatus is recovered to the initial state, the pressure is recovered to be between the first bubble threshold value and the second bubble threshold value again; therefore, the situation that micro-bubbles exist in the infusion apparatus and can be at the position of the bubble sensor but do not influence the infusion is explained, and therefore, the execution event is determined to be that the liquid stopping clip is in the opening state and the pump piece is in the moving state according to the feedback signal of the bubble sensor during the movement and the pressure during the movement, and the infusion pump can be kept in the infusion state in the micro-bubbles state.

In some embodiments of the present invention, when the infusion pump is in the first operating mode, the pressure sensor configured in the infusion pump can also monitor the pressure in the infusion apparatus, during a period when the liquid stopping clip is in a liquid stopping state, when a pump blade of the infusion pump drives liquid in the infusion apparatus to move, the pressure in the infusion apparatus changes due to a change in a form of a radial pipe diameter, when the processor determines that the pressure in the infusion apparatus changes according to the pressure sensor, the processor obtains an output amplitude of a feedback signal of a corresponding bubble sensor, when the processor detects that the pressure in the infusion apparatus recovers to its original state according to the pressure sensor, the processor obtains the output amplitude of the feedback signal of the bubble sensor at a corresponding time, and determines one of the execution events according to the feedback signal during the movement, including:

and according to the feedback signal during the movement, determining that the generation amplitude of the feedback signal during the movement is reduced and is lower than the second bubble threshold, or the generation amplitude of the feedback signal is increased, or the feedback signal keeps a steady state, driving the pump sheet to stop and outputting prompt information related to residual liquid drops. Specifically, as shown in the foregoing fig. 10B and 10C, a single residual liquid droplet in the liquid reservoir does not change in form due to the radial change of the infusion apparatus, so that the output amplitude of the feedback signal of the bubble sensor is still maintained between the first bubble threshold and the second bubble threshold, or a plurality of residual liquid droplets form a complete liquid column, when the residual liquid droplet passes through the bubble sensor, the output amplitude of the feedback signal of the bubble sensor is greatly increased, and when the liquid column leaves the same bubble sensor, the output amplitude of the feedback signal of the bubble sensor is greatly decreased, thereby indicating that the residual liquid droplet appears in the infusion apparatus, so that the processor can maintain the liquid stop state of the infusion pump through a corresponding control command in the first operation mode and send out a prompt message of the residual liquid droplet to prompt medical staff to process the residual liquid droplet appearing in time. Further, the infusion pump further comprises a liquid stopping clamp motor, and the liquid stopping clamp motor is used for controlling the state of the liquid stopping clamp. The processor can control the starting and stopping of the electric shock of the liquid stopping clamp through a control instruction according to different forms of bubbles in the infusion apparatus so as to realize the opening and closing of the liquid stopping clamp.

S1010: maintaining the infusion state of the infusion pump;

s1011: and stopping the infusion operation of the infusion pump and sending alarm prompt information.

The sent alarm prompt information includes, but is not limited to, audio alarm information and visual alarm information sent by the infusion pump structure shown in fig. 1, and is used for prompting that large bubbles or residual liquid drops appear in the infusion apparatus.

Fig. 11 is a flow chart of judging the existence degree of bubbles by using the infusion pump of the present invention, wherein the structure of the infusion pump used is as shown in the aforementioned fig. 6, wherein the number of the bubble sensors in the infusion pump is two, and the two bubble sensors are respectively a first bubble sensor and a second bubble sensor, the first bubble sensor and the second bubble sensor are distributed and arranged side by side along the infusion direction, and the sensing signal transmitting end and the sensing signal receiving end of the bubble sensor are arranged along the side edge of the infusion apparatus; the processor of the infusion pump is used for determining the existence degree of the bubbles in the infusion set by operating the executable instructions stored in the memory, and responding to the existence degree of the bubbles in the infusion set to execute the corresponding event when the infusion pump is in the infusion state, specifically, the liquid in the infusion set sequentially flows through the first bubble sensor and the second bubble sensor, and the second bubble sensor is closer to the patient. The processor of the infusion pump can receive feedback signals respectively corresponding to the first bubble sensor and the second bubble sensor, and can convert the feedback signals into corresponding output amplitude values of the feedback signals for output; the processor can also judge the existence degree of the bubbles in the infusion apparatus in a synergic manner according to the feedback signals corresponding to the first bubble sensor and the second bubble sensor, and the specific steps comprise:

s1101: and converting the received feedback signals respectively corresponding to the first bubble sensor and the second bubble sensor into corresponding output amplitude values to output.

Fig. 12 is a schematic diagram of output of feedback signals in an embodiment of the present invention, and as shown in fig. 12, a processor of an infusion pump converts received feedback signals corresponding to a first bubble sensor and a second bubble sensor into corresponding output amplitudes for output, where the first feedback signal is a signal transmitted by the first bubble sensor in a first acquisition time range and received by the first bubble sensor, the second feedback signal is a signal transmitted by the second bubble sensor in a second acquisition time range and received by the second bubble sensor, and the processor converts the received feedback signals corresponding to the first bubble sensor and the second bubble sensor into corresponding output amplitudes for output. Further, the bubble threshold includes a first bubble threshold and a second bubble threshold, where the first bubble threshold is greater than the second bubble threshold, an output amplitude of a feedback signal of the first bubble sensor is recorded as a first output amplitude, an output amplitude of a feedback signal of the second bubble sensor is recorded as a second output amplitude, an interval in which the feedback signal is greater than the first bubble threshold is recorded as an interval 1, an interval in which the feedback signal is smaller than the first bubble threshold and greater than the second bubble threshold is recorded as an interval 2, and an interval in which the feedback signal is smaller than the second bubble threshold is recorded as an interval 3.

In one embodiment of the present invention, since the usage environment and the liquid carried in the infusion pump are different, the difference between the first bubble threshold and the second bubble threshold in different usage environments can be stored in the storage medium of the infusion pump, and when only the first bubble threshold or the second bubble threshold is known, the corresponding first bubble threshold and the second bubble threshold of the infusion pump in the current usage environment can be known through the corresponding difference.

When the infusion pump described in the preceding embodiment is used, since the infusion pump is in different infusion environments and different types of liquids, the bubble threshold value corresponding to the type of the medicine or the injection can be stored in the storage medium of the infusion pump. In some embodiments of the present invention, during a clinical use process, a user may set different comparison databases according to different use environments, where the different comparison databases include bubble thresholds in different use environments, and further, the infusion pump may further store the used comparison databases set by different users, so that the same user may conveniently call the corresponding comparison database during the use process, so as to save a preparation time for the user to use the infusion pump.

S1102: judging whether the first output amplitude and the second output amplitude are changed to be within an interval 1, if so, executing S1103, otherwise, executing S1104;

the first output amplitude and the second output amplitude are changed to the interval 1, which indicates that no bubble occurs in the infusion apparatus, or the volume of the bubble occurs is small, and no micro-bubble is formed, so that the infusion safety is not affected.

S1103: the infusion state of the infusion pump is kept, and no alarm is given.

S1104: and judging whether the first output amplitude and the second output amplitude sequentially change to the interval 3, if so, executing S1105, otherwise, executing S1106.

S1105: the presence of large bubbles in the infusion set is determined and the volume of large bubbles present is calculated.

When large bubbles appear in the infusion apparatus, the large bubbles in the infusion apparatus move along the infusion direction along with the progress of infusion and sequentially pass through the first bubble sensor at the far end and the second bubble sensor at the near end, so that the first output amplitude and the second output amplitude sequentially change to the interval 3.

S1106: and judging whether the feedback signal shows that the second output amplitude value changes to the interval 2 or not, keeping the first output amplitude value at the interval 1, if so, executing S1110, and otherwise, executing S1111.

S1107: judging whether the volume of the bubbles is larger than a corresponding alarm gear or not according to the calculation result of the volume of the bubbles, if so, executing S1108, otherwise, executing S1109;

V ₂ ＝v ₂ ×d ₂ ×t ₂ (2)

V ₂ is the volume of the large bubble; v. of ₂ The flow rate of the infusion apparatus in unit time at the current alarm gear can be set according to medical advice; d ₂ The diameter of the infusion set; t is t ₂ The output amplitude of the first or second feedback signal is below the second bubble threshold time.

S1108: and stopping the infusion operation of the infusion pump and sending alarm prompt information.

The infusion operation of the infusion pump can be stopped by keeping the infusion pump driving mechanism in a liquid stopping state, and the sent alarm prompt information is the prompt information related to large bubbles.

S1109: the calculation result of the bubble volume is counted into the cumulative bubble amount.

In one embodiment of the invention, different alarm gears of the infusion apparatus correspond to different bubble alarm thresholds, and when the calculated volume of the large bubbles does not exceed the preset bubble alarm threshold, the processor maintains the infusion state of the infusion pump through a corresponding control instruction and updates the accumulated bubble amount in the memory. Further, when the accumulated bubble amount exceeds the preset limit, the processor can stop the operation of the infusion pump through a corresponding control instruction and output corresponding prompt information related to the exceeding of the accumulated bubble amount.

S1110: and determining that residual liquid drops appear in the infusion apparatus, keeping the liquid stopping state of the infusion pump driving mechanism, and sending information related to the residual liquid drops.

S1111: and judging whether the fed back signal shows that the first output amplitude and the second output amplitude both change to the interval 2 and the time difference meets a preset time value, if so, executing S1112, otherwise, executing S1113.

In some embodiments of the present invention, the memory is further configured to store feedback history information of the first bubble sensor and the second bubble sensor, and the processor is further configured to determine a first feedback time when the feedback signal of the first bubble sensor is in an interval between the first bubble threshold and the second bubble threshold, determine a second feedback time when the feedback signal of the second bubble sensor is in an interval between the first bubble threshold and the second bubble threshold, and determine a residual droplet or a micro-bubble in the infusion set according to the first feedback time and the second feedback time. Specifically, the processor may determine a time difference between the first feedback time and the second feedback time according to the first feedback time and the second feedback time, and determine a residual liquid droplet or a micro-bubble in the infusion apparatus according to the time difference, where as shown in fig. 12, a time difference may exist between changes of the first output amplitude and the second output amplitude, and the time difference satisfies a preset time value, and may determine that the residual liquid droplet occurs in the infusion apparatus, in this process, since the residual liquid droplet sequentially passes through monitoring ranges of the first bubble sensor and the first bubble sensor, a change of the first output amplitude and the second output amplitude to an interval 2 may be caused within the corresponding time difference. Further, when the micro bubbles appear in the infusion apparatus, the micro bubbles may be clamped at the first bubble sensor and the second bubble sensor, and at this time, the attenuation time of the feedback signal of the bubble sensors is random and has no sequence, and cannot meet a preset time value, wherein the preset time value is related to the tube diameter of the infusion apparatus, the infusion flow rate, and the distance between the first bubble sensor and the second bubble sensor.

In some embodiments of the invention, table 1 shows a table of records of the variation to interval 2 according to the respective output amplitudes entered by the first and second bubble sensors. The preset time difference value is 1 minute, wherein the time difference between the interval 2 of the sequential change of the first output amplitude value and the second output amplitude value in the number 1 is 1 minute, and the occurrence of residual liquid drops in the infusion apparatus can be determined according with the preset time difference value; the time difference from the first output amplitude value and the second output amplitude value in the serial number 2 to the interval 2 is 5 minutes, the preset time difference is exceeded, the attenuation time of the feedback signal of the bubble sensor is random, the sequence is not required, and the micro bubbles in the infusion apparatus can be determined; the time difference from the first output amplitude value and the second output amplitude value in the number 3 to the interval 2 is 2 minutes, and the micro bubbles in the infusion apparatus can be determined to appear when the preset time difference is exceeded; and the first output amplitude and the second output amplitude in the number 4 are simultaneously changed to the interval 2, and the situation that the micro bubbles and the residual liquid drops simultaneously appear in the infusion apparatus is determined.

TABLE 1

It should be noted that, as shown in fig. 12, the change of the first output amplitude and the second output amplitude may be changed to an interval 2 at the same time, at this time, it may be determined that micro bubbles or residual liquid droplets simultaneously appear in the infusion apparatus, and the appeared micro bubbles or residual liquid droplets are simultaneously clamped at the first bubble sensor and the second bubble sensor, at this time, the infusion pump may stop infusion, and prompt the user to check the state of the infusion apparatus through corresponding prompt information.

S1112: and determining that residual liquid drops appear in the infusion apparatus, keeping the liquid stopping state of the infusion pump driving mechanism, and sending prompt information related to the residual liquid drops.

The sent prompt information includes, but is not limited to, audio alarm information and visual alarm information sent by the infusion pump structure described in the foregoing fig. 1, so as to prompt the occurrence of large bubbles or residual liquid droplets in the infusion apparatus.

S1113: and determining the existence degree of the bubbles in the infusion apparatus as micro bubbles, and keeping the infusion state of the infusion pump.

Fig. 13 is a flow chart of determining the existence of bubbles by using the infusion pump of the present invention, wherein the structure of the infusion pump is as shown in any of the foregoing embodiments, and the sensing signal receiving terminal is configured to receive a feedback signal generated by attenuation of the sensing signal through the infusion apparatus; wherein, when the number of the bubble sensors in the infusion pump is one, the one bubble sensor can emit a plurality of sensing signals with different emission frequencies; when the number of the bubble sensors in the infusion pump is at least two, the at least two bubble sensors in the infusion pump respectively emit at least one sensing signal, and the signal frequency of each sensing signal is different; the method comprises the following steps:

step 1301: at least two sensing signals having different transmission frequencies are transmitted.

When the structure of the infusion pump is as shown in the previous sequence fig. 3, wherein the number of the bubble sensors is one, the bubble sensors are driven to emit at least two sensing signals with different emission frequencies, so that the sensing signal emitting end can emit a plurality of sensing signals with different amplitude-frequency characteristics.

When the infusion pump is constructed as shown in the foregoing fig. 6 or 7, in which the number of bubble sensors is at least two, it is possible to transmit at least two sensing signals having different transmission frequencies by driving each sensor; alternatively, when the number of the bubble sensors is at least two, the at least two sensors may be driven to emit a sensing signal, and the emitted sensing signals have different emission frequencies.

It should be noted that, because the tube wall thicknesses of the infusion sets are not completely the same, the switching frequency between the sensing signals at the transmitting ends of the sensors is greater than or equal to 10HZ, and when the frequency is greater than or equal to 10HZ, the sensing signals can obtain clearer feedback signals through the attenuation of the infusion set.

Step 1302: and receiving feedback signals corresponding to the plurality of sensing signals.

Step 1303: a target feedback signal is determined from the received plurality of feedback signals.

Wherein, when the structure of the infusion pump is as shown in the foregoing fig. 7, and the number of the bubble sensors is three, fig. 14 shows a schematic diagram of resonant frequencies of the feedback signals corresponding to the sensing signals with different emission frequencies of the bubble sensor in the present invention, wherein the influence factors of the dispersion of the resonant frequencies of the feedback signals include but are not limited to: the material of the infusion apparatus, the diameter of the infusion apparatus and the installation error of the infusion apparatus. As shown in fig. 14, the amplitude-frequency characteristics of different bubble sensors have a certain dispersion, which is reflected in the difference between the output amplitude of the feedback signal and the resonance frequency point. Fig. 14 shows the resonant frequencies of three bubble sensors, wherein the three bubble sensors are respectively marked as the bubble sensor No. 1, the bubble sensor No. 2 and the bubble sensor No. 3, and are distributed along the infusion direction, and when the infusion pump is in the infusion state, the other in the infusion set flows through the bubble sensor No. 1, the bubble sensor No. 2 and the bubble sensor No. 3 in sequence. Specifically, as shown in fig. 14, the resonance frequency points of the sensor No. 1 and the sensor No. 2 are greatly different, while the resonance frequency points of the sensor No. 2 and the sensor No. 3 are the same, but the absolute amplitude of the sensor No. 2 is lower than that of the sensor No. 3. If a single frequency point is used for driving the ultrasonic ceramic wafer of the sensor, the amplitude of the output feedback signal has larger discreteness. Taking fig. 14 as an example, when the frequency f1 is used, the sensor No. 1 is normal, but the output amplitudes of the sensor No. 2 and the sensor No. 3 are too low, and when the frequency f3 is used, the output amplitude of the sensor No. 1 is too low, and the signal of the sensor No. 3 is saturated, so that the accurate feedback signal can be obtained regardless of which sensing signal with a single emission frequency is used.

In some embodiments of the present invention, the transmission frequencies of the sensing signals at the sensing signal transmitting ends are different. Specifically, when the number of the sensors in the infusion pump is at least two, the state of bubbles in the infusion apparatus can be detected more accurately by setting different emission frequencies of the sensing signals of the sensing signal emission ends, the discreteness of different ultrasonic sensors is improved, and the saturation probability of the sensing signals (or feedback signals) is reduced.

In an embodiment of the present invention, a transmission frequency of a transmission mode of the sensor is a resonance frequency of the sensor to achieve obtaining a clear feedback signal, and further, a transmission frequency of at least one time period of the sensor is 0, which enables self-checking of the sensing signal. Further, the driving signal of the sensor comprises 3 frequency points and a section of self-checking signal, the amplitude of the self-checking signal is zero, if the self-checking signal works normally, the output amplitude of the bubble sensor at the section is also zero, and if the amplitude of the self-checking signal is zero, the output amplitude of the bubble sensor at the section is not zero, the situation that the infusion apparatus is broken and the infusion apparatus needs to be replaced in time or the bubble sensor is damaged and needs to be replaced is indicated.

In some embodiments of the present invention, the output interface may be a peripheral interface as described in the above embodiments.

Further, fig. 15 shows a schematic diagram of the feedback signal output amplitude of 3 different bubble sensors in the present invention, as shown in fig. 15, the sensor No. 1 is too low at the frequency f3, the sensor No. 2 is too low at the frequencies f1 and f2, and the sensor No. 3 is saturated when the signal appears at the frequency f 3. Therefore, the amplitudes of the No. 1 sensor, the No. 2 sensor and the No. 3 sensor are in proper positions when the frequency is f2, the frequency is f3 and the frequency is f2, and therefore output amplitude data corresponding to the frequency points can be used when bubbles in the infusion set are detected. It should be noted that, in practical application, the empirical value of the output amplitude of the ultrasonic sensor can be counted through a large amount of data, the frequency point corresponding amplitude closest to the value is taken for each sensor, and the size of the bubble in the infusion apparatus is calculated, wherein the empirical value of the output amplitude is an actual value which can meet clinical detection.

In some embodiments of the present invention, an amplitude-frequency characteristic value of the infusion pump may be further preset, wherein the target feedback signal is adapted to the preset amplitude-frequency characteristic value. Specifically, in the process of determining the existence degree of the bubbles in the infusion apparatus according to the feedback signals of different emission frequencies, the processor may count an empirical value of the output amplitude of the ultrasonic sensor through a large amount of data, and since the empirical value of the output amplitude of the ultrasonic sensor is related to the diameter of the infusion apparatus, the apparatus information may be pre-stored in an apparatus library Database (DB), wherein the apparatus information includes but is not limited to: the infusion apparatus diameter and brand information matched with the infusion pump are used by medical personnel to call corresponding data by using the equipment database, so that the empirical value of the output amplitude of the ultrasonic sensor can be selected or set, and the preparation time of the infusion pump before use is prolonged.

In some embodiments of the present invention, the empirical value of the output amplitude is related to the circuit output range of the bubble sensor, and the empirical value of a particular output amplitude may take a value between saturating the output circuit and an excessively low output voltage. For example, the output range of the circuit of the bubble sensor is 0.2V-5V, the saturation output voltage is 5V, the too low output voltage is 0.2V, and the empirical value of the output amplitude can be selected to be 2.5V-3V. For example, the output range of the circuit of the bubble sensor is 0.2V-3.3V, the saturation output voltage is 3.3V, the too low output voltage is 0.2V, and the empirical value of the output amplitude can be selected to be 2.5V-3V.

Step 1304: determining the degree of presence of air bubbles in the infusion set from the determined target feedback signal.

Step 1305: and judging whether the infusion set generates large bubbles or not according to the determined target feedback signal, if so, executing step 1307, and otherwise, executing step 1306.

Step 1306: and determining the existence degree of the bubbles in the infusion pump as micro bubbles, and keeping the infusion state of the infusion pump.

Specifically, the bubble threshold includes a first bubble threshold and a second bubble threshold, and the first bubble threshold is greater than the second bubble threshold. When the output amplitude of the target feedback signal is not smaller than the first bubble threshold value, it indicates that micro bubbles begin to appear in the infusion apparatus, even no bubbles exist, and no influence is caused on the infusion safety.

Step 1307: the presence of large bubbles in the infusion set is determined and the volume of large bubbles present is calculated.

In some embodiments, when the determined output amplitude of the target feedback signal is less than the second bubble threshold, it indicates that a large bubble occurs in the infusion set, wherein the large bubble in the infusion set may be formed by a single bubble or by aggregation of multiple bubbles; because the infusion pumps are not equipped with the same liquid medicine, the corresponding alarm gears of the infusion sets in different use environments are not completely the same, and certainly, the volumes of the large bubbles which trigger the infusion pumps to stop working are different corresponding to different alarm gears. Specifically, in calculating the large bubble volume, the processor may calculate the volume of the large bubble according to the formula:

V ₃ ＝v ₃ ×d ₃ ×t ₃ (2)

V ₃ is the volume of the large bubble; v. of ₃ The flow rate of the infusion apparatus in unit time at the current alarm gear can be set according to medical advice; d is a radical of ₃ The diameter of the infusion set; t is t ₃ The determined output amplitude of the target feedback signal is below the second bubble threshold time.

Step 1308: judging whether the volume of the air bubble is larger than a corresponding alarm gear or not according to the calculation result of the volume of the air bubble, if so, executing S1309, otherwise, executing S1310;

step 1309: keeping a liquid stopping state and sending out reminding information;

wherein, the sent reminding information can be prompting information which is sent by an output interface of the infusion pump and relates to large bubbles.

Step 1310: the accumulated bubble amount is updated and output.

The embodiment of the invention also provides medical equipment, the medical equipment is used for being connected with the infusion pump provided by the application through the output interface, and the medical equipment is provided with an output device which is used for displaying information output by the output interface. Specifically, the infusion pump may send prompt information related to the large bubble to the medical device through the output interface, so as to display visual prompt information related to the large bubble on a display system/light assembly included in an output device of the medical device, or send out an alarm audio through an audio circuit included in the output device of the medical device.

In some embodiments of the present invention, the infusion pump may send a prompt to the medical device via the output interface relating to the exceeding of the accumulated bubble amount, to display a visual prompt relating to the exceeding of the accumulated bubble amount on a display system/light assembly included in an output device of the medical device, or to emit an alarm audio via an audio circuit included in the output device of the medical device.

In some embodiments of the present invention, the infusion pump may send the current accumulated bubble volume information to the medical device through the output interface, so as to display a visual prompt message of the current accumulated bubble volume on a display system/light assembly included in an output device of the medical device, or send a voice report through an audio circuit included in the output device of the medical device, so as to prompt a user of the current accumulated bubble volume.

Taking the iv set shown in fig. 1 as an example, the method disclosed in the embodiment of the present invention may be applied to the processor 150, or may be implemented by the processor 150. The processor 150 may be an integrated circuit chip having signal processing capabilities. In implementation, the steps of the above method may be performed by integrated logic circuits of hardware or operations in the form of software in the processor 150. The Processor 150 may be a general purpose Processor, a Digital Signal Processor (DSP), or other programmable logic device, discrete gate or transistor logic device, discrete hardware components, etc. Processor 150 may implement or perform the methods, steps, and logic blocks disclosed in embodiments of the present invention. A general purpose processor may be a microprocessor or any conventional processor or the like. The steps of the method disclosed by the embodiment of the invention can be directly implemented by a hardware decoding processor or implemented by a combination of hardware and software processors in the decoding processor. The software processor may be located in a storage medium located in the memory 104, and the processor 150 reads the information in the memory 104 and performs the corresponding steps described above in connection with its hardware.

In an exemplary embodiment, the iv Device may be implemented by one or more Application Specific Integrated Circuits (ASICs), DSPs, programmable Logic Devices (PLDs), complex Programmable Logic Devices (CPLDs), field Programmable Gate Arrays (FPGAs), general purpose processors, controllers, micro-controllers (MCUs), microprocessors (microprocessors), or other electronic components configured to perform the monitoring information output method.

In an exemplary embodiment, embodiments of the present invention also provide a computer readable storage medium, such as the memory 104, comprising a computer program executable by the processor 150 for monitoring an iv set to perform the steps of the aforementioned method. The computer readable storage medium can be Memory such as FRAM, ROM, PROM, EPROM, EEPROM, flash Memory, magnetic surface Memory, optical disk, or CD-ROM; or may be various devices, such as a portable analyzer, etc., including one or any combination of the above-described memories.

An embodiment of the present invention further provides a computer-readable storage medium, on which a computer program is stored, where the computer program, when executed by a processor, performs:

receiving feedback signals corresponding to a plurality of sensing signals;

performing one of the following events:

keeping a liquid stopping state and sending out reminding information; or

The transfusion state is maintained.

As will be appreciated by one skilled in the art, embodiments of the present invention may be provided as a method, system, or computer program product. Accordingly, embodiments of the present invention may take the form of a hardware embodiment, a software embodiment, or an embodiment combining software and hardware aspects. Furthermore, embodiments of the present invention may take the form of a computer program product embodied on one or more computer-usable storage media (including magnetic disk storage, optical storage, and the like) having computer-usable program code embodied in the medium.

Embodiments of the present invention are described with reference to flowchart illustrations and/or block diagrams of methods, apparatus (systems), and computer program products according to embodiments of the invention. It will be understood that each flow and/or block of the flowchart illustrations and/or block diagrams, and combinations of flows and/or blocks in the flowchart illustrations and/or block diagrams, can be implemented by computer program operations. These computer programs may be provided to a processor of a general purpose computer, special purpose computer, embedded processor, or other programmable data processing apparatus to produce a machine, such that the operations performed by the processor of the computer or other programmable data processing apparatus produce means for implementing the functions specified in the flowchart flow or flows and/or block diagram block or blocks.

These computer program operations may also be stored in a computer-readable memory that can direct a computer or other programmable data processing apparatus to function in a particular manner, such that the operations stored in the computer-readable memory produce an article of manufacture including operating means which implement the function specified in the flowchart flow or flows and/or block diagram block or blocks.

These computer program operations may also be loaded onto a computer or other programmable data processing apparatus to cause a series of operational steps to be performed on the computer or other programmable apparatus to produce a computer implemented process such that the operations executed on the computer or other programmable apparatus provide steps for implementing the functions specified in the flowchart flow or flows and/or block diagram block or blocks.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and should not be taken as limiting the scope of the present invention, which is intended to cover any modifications, equivalents, improvements, etc. within the spirit and scope of the present invention.

Claims

1. An infusion pump is characterized in that the infusion pump is used in cooperation with an infusion apparatus, and performs infusion operation set by a user according to liquid configured by the user; the infusion pump comprises an infusion pump driving mechanism, an infusion pipeline, a sensor, a processor, a memory, a liquid stopping clamp and an output interface; wherein the infusion pump drive mechanism comprises a pump blade; the infusion pipeline is used for arranging the infusion apparatus; the sensor comprises a sensing signal transmitting end and a sensing signal receiving end, the sensing signal transmitting end is used for transmitting a sensing signal, the sensing signal receiving end is used for receiving a feedback signal, the feedback signal is a signal formed by the change of the sensing signal after passing through the infusion apparatus, and the sensing signal transmitting end and the sensing signal receiving end are arranged along the side edge of the infusion apparatus; the sensing signal transmitting end is used for transmitting at least two sensing signals based on different transmitting frequencies; the processor is configured to drive the sensing signal transmitting terminal to transmit at least two sensing signals based on different transmitting frequencies, and correspondingly receive a feedback signal fed back based on the sensing signals, where the feedback signal includes a plurality of feedback signals, and each feedback signal corresponds to a different sensing signal, and perform one of the following events:

driving the infusion pump driving mechanism to keep a liquid stopping state and sending out reminding information through the output interface; or

And driving the infusion pump driving mechanism to keep an infusion state.

2. The infusion pump of claim 1, wherein said processor is configured to determine a degree of presence of air bubbles within said infusion set based on said feedback signal prior to said performing event.

3. The infusion pump of claim 2, wherein said processor is configured to determine a target feedback signal based on said feedback signal, determine a degree of presence of said bubble based on said target feedback signal, and characterize said feedback signal with signal amplitude-frequency characteristics adapted to an operating condition of said infusion pump.

4. The infusion pump according to claim 3, wherein said processor determines a degree of presence of a bubble in said infusion set as a large bubble based on a target feedback signal and a preset bubble threshold, and selects one of the following events based on said large bubble: and driving the infusion pump driving mechanism to keep a liquid stopping state and sending out reminding information related to large bubbles through the output interface, or updating the accumulated bubble amount and outputting the accumulated bubble amount through the output interface.

5. The infusion pump according to claim 4, wherein said processor is configured to determine a volume of said large bubbles after determining a level of presence of said bubbles in said infusion set as large bubbles, and to select one of the following events to be performed based on said volume and a preset bubble alarm threshold: and driving the infusion pump driving mechanism to keep a liquid stopping state and sending out reminding information related to large bubbles through the output interface, or updating the accumulated bubble amount and outputting the accumulated bubble amount through the output interface.

6. The infusion pump according to claim 3, wherein said processor determines a level of presence of bubbles in said infusion set as microbubbles based on the target feedback signal and a preset bubble threshold, and performs the following events based on said microbubbles: and driving the infusion pump driving mechanism to keep an infusion state.

7. The infusion pump of claim 1, wherein one of said emission frequencies is a resonant frequency of said sensor.

8. The infusion pump of claim 1, wherein said processor is further configured to determine an operational status of the infusion pump based on said feedback signal, and output a corresponding operational status prompt via said output interface based on said operational status.

9. The infusion pump according to claim 1, wherein said infusion pump comprises a plurality of sensor signal emitting ends, wherein at least one of said sensor signal emitting ends emits sensor signals of a plurality of different amplitude-frequency characteristics.

10. The infusion pump of claim 1, wherein said infusion pump comprises a sensor signal emitting end, wherein said sensor signal emitting end emits a plurality of sensor signals having different amplitude-frequency characteristics.

11. The infusion pump according to claim 1, wherein said infusion pump comprises a plurality of said sensor signal emitting terminals, wherein the amplitude-frequency characteristics of the sensor signals emitted by each of said sensor signal emitting terminals are different.

12. The infusion pump according to claim 1, wherein a switching frequency between said sensing signals of said different emission frequencies is greater than or equal to 10HZ.

13. A medical device for connection to an infusion pump according to any of claims 1-12 via the output interface, wherein an output device is provided on the medical device for displaying information output by the output interface.

14. A storage medium storing executable instructions configured to cause a processor to implement a method of operating an infusion pump when the executable instructions are executed; the working method is applied to an infusion pump, the infusion pump is used in cooperation with an infusion apparatus, and infusion operation set by a user is executed according to liquid configured by the user;

the working method comprises the following steps:

receiving feedback signals corresponding to a plurality of sensing signals, wherein the feedback signals comprise a plurality of feedback signals, and each feedback signal corresponds to a different sensing signal;

performing one of the following events:

keeping a liquid stopping state and sending out reminding information; or alternatively

The transfusion state is maintained.

15. The storage medium of claim 14, wherein said transmitting at least two sensing signals having different transmit frequencies comprises:

driving at least one sensor of the plurality of sensors to emit at least two sensing signals having different emission frequencies; or

Driving a plurality of sensors to emit the sensing signals, wherein the amplitude-frequency characteristics of the sensing signals are different; or

A sensor is driven to emit at least two sensing signals having different emission frequencies.

16. The storage medium of claim 14, further comprising, prior to the executing event:

determining the existence degree of bubbles in the infusion apparatus according to the received plurality of feedback signals;

the execution event comprises:

according to the existence degree of the bubbles, selecting to execute one of the following events: keeping a liquid stopping state and sending out reminding information; or updating the accumulated bubble amount and outputting the accumulated bubble amount; or maintain the infusion state.

17. The storage medium of claim 16, wherein said determining a degree of presence of a bubble in the infusion set from the received plurality of feedback signals comprises:

determining a target feedback signal from the received plurality of feedback signals;

and determining the existence degree of the bubbles according to the target feedback signal.

18. The storage medium of claim 17, wherein the method of operation further comprises:

presetting an amplitude-frequency characteristic value of the infusion pump, wherein the target feedback signal is matched with the preset amplitude-frequency characteristic value.

19. The storage medium of claim 17, wherein said determining the degree of bubble presence from a target feedback signal comprises:

determining the existence degree of bubbles in the infusion apparatus as large bubbles according to the target feedback signal and a preset bubble threshold value;

the selecting to execute one of the events according to the existence degree of the air bubbles comprises:

selecting one of the following events to be executed according to the large bubble: maintaining a liquid-stopping state and issuing a warning message concerning large bubbles, or updating an accumulated bubble amount and outputting the accumulated bubble amount.

20. The storage medium of claim 19, wherein after determining that the degree of presence of air bubbles in the infusion set is large, further comprising:

determining the volume of the large bubble;

and according to the volume and a preset bubble alarm threshold, selecting to execute one of the following events: and keeping the liquid stopping state and sending out reminding information related to large bubbles, or updating the accumulated bubble amount and outputting the accumulated bubble amount.

21. The storage medium of claim 17, wherein said determining the degree of bubble presence from a target feedback signal comprises:

determining the existence degree of bubbles in the infusion apparatus as tiny bubbles according to the target feedback signal and a preset bubble threshold value;

performing the following events according to the micro-bubbles: the transfusion state is maintained.