CN112107636A - Formula and preparation process of traditional Chinese medicine preparation for treating osteoarthropathy - Google Patents

Abstract

The invention relates to a Chinese medicinal preparation and its preparing process, wherein the preparation is prepared from the following constituents (by weight portions): 35-40 parts of angelica sinensis, 35-40 parts of cinnamon, 25-30 parts of cynomorium songaricum (also known as Sha Di Ke), 25-30 parts of asarum, 10-15 parts of akebia stem, 25-30 parts of white peony root, 10-15 parts of wild watermelon (Poliko), 15-30 parts of dried pepper, 5-15 parts of mint and 1.0-1.5 parts of borneol, and the preparation process comprises the following steps: weighing radix Angelicae sinensis, cortex Cinnamomi, herba asari, dried Capsici fructus, and herba Menthae; distilling with water vapor to obtain volatile oil; weighing herba Cynomorii, caulis Akebiae, and radix Paeoniae alba, mixing the two Chinese medicinal residues, decocting with water, and extracting decoction; weighing and crushing the wild watermelon, extracting the wild watermelon extracting solution, preparing the decoction into thick extract, mixing the thick extract with a blank substrate, adding the extracted volatile oil and stirring.

Description

A kind of traditional Chinese medicine preparation formula for treating osteoarthropathy and preparation process thereof

technical field

The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a traditional Chinese medicine preparation formula for treating osteoarthropathy and a preparation process thereof.

Background technique

Osteoarthritis is mainly caused by osteoarthritis and is a joint disease with the highest incidence. The incidence of osteoarthritis is related to climate and age. The incidence rate of the general population is 3%. The incidence rate is about 70%. With the increase of aging in our country, the incidence of this disease is increasing. In the early stage of osteoarthritis, joint pain, articular cartilage degeneration, inflammation of joint synovium and subchondral bone lesions appear, leading to joint wear and tear, Joint deformation, resulting in functional limitations and various degrees of deformity. Compared with other diseases, osteoarthropathy has a slow disease progression, but it has a high incidence and involves a wide range of areas. In addition, there are acute and chronic symptoms. Affect people's physical and mental health, such as knee osteoarthritis, lumbar spondylosis, frozen shoulder and other osteoarthritis will make patients with limited function, pain, unbearable, severe cases are horrific, the pain is unbearable, and seriously affect the patient's health. The production capacity, and even the loss of work ability, has caused a huge burden to the patient himself, his family, and the society.

In the prior art, the treatment of osteoarthritis is mainly based on western medicine, and the clinical treatment of osteoarthritis is mainly to relieve joint pain and improve joint symptoms. Long-term oral drugs have side effects that aggravate cardiovascular and gastrointestinal adverse reactions. In addition, the use of intra-articular drug injection has the risk of infection, and the use of surgery is not easy to be accepted by patients due to its high cost and high risk. Among the external drugs for various osteoarthritis, there has been no traditional Chinese medicine, which is suitable for the grass-roots level. For external treatment of traditional Chinese medicine promoted by technology in hospitals and patients, most of the existing traditional Chinese medicine preparations only pay attention to strong attack (activating blood and removing blood stasis and expelling wind and dampness), while ignoring the double nourishment of qi and blood, so the effect is not very good.

SUMMARY OF THE INVENTION

In view of the above problems, the purpose of the present invention is to provide a traditional Chinese medicine formulation and its preparation technology with significant curative effect, small side effects, both symptoms and root causes, low treatment cost, simple and convenient treatment operation, and can play a combined effect of prevention and treatment.

The object of the present invention is achieved through the following technical solutions: A kind of traditional Chinese medicine preparation formula for the treatment of osteoarthritis, the traditional Chinese medicine raw materials are proportioned according to the following parts by weight: 35-40 parts of Angelica sinensis, 35-40 parts of cinnamon, Cynomorium Buy Dike) 25-30 parts, Asarum 25-30 parts, Mutong 10-15 parts, Bai Shao 25-30 parts, Wild watermelon (Polik fruit) 10-15 parts, Dried peppers 15-30 parts, Mint 5-15 parts, borneol 1.0-1.5 parts.

Preferably, the traditional Chinese medicine raw materials are proportioned according to the following parts by weight: 40 parts of Angelica sinensis, 40 parts of cinnamon, 30 parts of Cynomorium (Yermaidi Ke), 30 parts of Asarum, 15 parts of Mutong, 30 parts of Paeonia lactiflora, Radix Paeoniae Alba 10 parts of watermelon (porik fruit), 20 parts of dried chili, 7.5 parts of mint, and 1.5 parts of borneol.

Preferably, the traditional Chinese medicine raw materials are proportioned according to the following parts by weight: 35 parts of Angelica sinensis, 35 parts of cinnamon, 25 parts of Cynomorium (Yermaidi Ke), 25 parts of Asarum, 10 parts of Mutong, 25 parts of Paeonia lactiflora, 15 parts of watermelon (pork fruit), 25 parts of dried chili, 10 parts of mint, 1.5 parts of borneol.

The present invention also includes a preparation process of the above-mentioned traditional Chinese medicine preparation for the treatment of osteoarthropathy, comprising the following steps:

Step 1, take by weighing the parts by weight in the above-mentioned traditional Chinese medicine formulation for the treatment of osteoarthritis, respectively Angelica sinensis, cinnamon, Asarum, dried chili pepper, mint;

Step 2, carry out distillation with water vapor by weighing the angelica, cinnamon, asarum, dried pepper, mint, extract volatile oil for later use, and dry the distilled angelica, cinnamon, asarum, dried pepper, peppermint dregs for drying or drying. drying for use;

Step 3, take by weighing Cynomorium, Mutong, Paeonia lactiflora by weight in the above-mentioned traditional Chinese medicine formulation for the treatment of osteoarthritis, with the angelica, cinnamon, Asarum, dried chili, mint after drying or drying in the same step 2 The medicinal residues are combined, then decocted with water, and the decoction is extracted for use;

Step 4, take by weighing the wild watermelon (Polik fruit) and pulverize according to the parts by weight in the above-mentioned traditional Chinese medicine formulation for the treatment of osteoarthropathy, use methanol as the extraction solution, and adopt the ultrasonic method to treat the main components of the wild watermelon volatile oil, volatile oil, Extract flavonoids, alkaloids and other compounds;

Step 5. Concentrate the wild watermelon extract and borneol extracted in step 4 and the decoction after decoction in step 3 to form a thick extract, and then mix the thick extract with a blank base (the blank base is mixed with vaseline and lanolin) composition), and finally adding the volatile oil extracted in step 2 and stirring evenly to obtain the finished Chinese medicine preparation.

Preferably, in the step 5, the wild watermelon extract extracted in the step 4 and the decoction after the decoction in the step 3 are concentrated and merged into a 0.2g/ml thick extract, and the thick extract and the blank matrix are mixed with (1: 1) Proportion mixing (blank base is composed of Vaseline and lanolin in a 2:1 ratio).

Preferably, in step 5, vaseline and lanolin are heated and melted in a water bath in a ratio of 2:1, and the above mixture is added at about 65° C. and mixed.

Preferably, in step 2, soak the weighed angelica, cinnamon, asarum, dried chili, and mint in water for 1-3 hours, add 10-12 times the amount of water, extract by steam distillation to obtain volatile oil, and put the medicinal residues Sun-dried and weighed Cynomorium (Yermaidi Ke), Mutong, and Paeonia lactiflora, which were weighed in step 3, and soaked for 1-2 hours. Add 8-12 times of water to decoct and extract. After boiling, keep slightly boiling for 1-1.5 hours. , extracted twice, filtered while hot, quickly cooled and combined the filtrate, then centrifuged to remove impurities, extracted the supernatant, concentrated under reduced pressure (temperature <50 ℃) to 0.2 g/ml of extract.

Preferably, in step 4, the wild watermelon (Polik fruit) is powdered, and the components are extracted with the help of ultrasonic waves: the concentration of the methanol extract is 90%, the extraction temperature is 80 ℃, and the extraction time is 35-40min.

The invention provides a traditional Chinese medicine preparation for external use with significant curative effect on osteoarthritis. The characteristics and functions of each component are as follows: Angelica sinensis and cinnamon are used as monarch medicines in the prescription. Cinnamon is used to invigorate the fire and help the yang, dispel cold and relieve pain, warm the meridians and dredge the meridians, and the combination of the two medicines can nourish the bones and joints, moisten the meridians, smooth the joints. , has the effect of tonifying kidney yang, nourishing essence and blood, moistening intestines and defecation, assisting monarch medicine, making blood vessels biochemically active, and the medicinal effect is more significant; white peony root nourishes blood and astringes yin, softens liver, relieves acute pain and relieves pain, and can be used as an adjuvant in prescriptions. Yang medicine, so that the patient will not rise too much Yang, burning the veins; Asarum, Mutong, Wild Watermelon (Polik fruit): help Yang to dispel cold, clear the meridians, dispel cold and dampness; Peppermint soothes the liver and dispels wind Heat, borneol fragrant opening, Tongli Xuanfu, under the synergy of techniques, together with dried chili to reconcile cold and heat, balance yin and yang, the medicines in the prescription must be in harmony with each other, and they can adjust to each other. It can nourish blood and astringe yin, soften liver and relieve urgency, and at the same time cooperate with the medicine for opening orifices, reconciling yin and yang cold and heat, and is suitable for various syndromes of bone and joint diseases. Smooth and benefit joints; nourish liver and kidney, strengthen tendons and bones.

Beneficial effects:

1. Treat both the symptoms and root causes, condense the essence of traditional Chinese medicine and Uyghur medicine for the treatment of osteoarthritis, and effectively combine Chinese and Uyghur medicine.

2. Pure Chinese Uygur medicine botanical preparations, without any chemicals, greatly reduce the adverse reactions of drug allergies and expand the scope of application.

3. The clinical effect is quick, reducing the unbearable pain of the patient for a long time. After the patient applies the medicine and cooperates with the manipulation, the pain can be alleviated or eliminated within 10-20 minutes.

4, the action time is long. The traditional Chinese medicine preparation of the present invention can use ointment as a dosage form for transdermal administration, which can not only avoid the first-pass effect of the liver, but also avoid the occurrence of gastrointestinal irritation and malabsorption, and can maintain a constant and lasting drug release. It has the advantages of high speed, reducing the number of administrations, etc., and can continue to play a role in the treatment of patients' joints in combination with massage manipulations.

5. It has a wide range of applications. This product is both internal and external, and has a lasting effect. It can treat a variety of osteoarthritis.

Description of drawings

Fig. 1: Flow chart of the preparation process of the traditional Chinese medicine preparation in Example 1 of the present invention.

Detailed ways

Specific embodiments of the present invention are given below for further detailed explanation of the content of the invention. This does not limit the scope of the patent of the present invention. Any equivalent structure or equivalent process transformation made by using the contents of the description and drawings of the present invention, or directly or indirectly used in other related technical fields, are similarly included in the patent of the present invention. within the scope of protection.

Embodiment 1, with reference to Fig. 1 a kind of traditional Chinese medicine preparation formula for the treatment of osteoarthropathy, the traditional Chinese medicine raw materials are proportioned according to the following parts by weight: 35-40 parts of Angelica sinensis, 35-40 parts of cinnamon, Cynomorium 25-30 parts, 25-30 parts Asarum, 10-15 parts Mutong, 25-30 parts white peony root, 10-15 parts wild watermelon (Polik fruit), 15-30 parts dry pepper, 5-15 parts mint 1.0-1.5 servings of borneol.

The present invention also includes a preparation process of the above-mentioned traditional Chinese medicine preparation for the treatment of osteoarthropathy, comprising the following steps:

Step 1, take by weighing respectively 35-40 parts of Angelica sinensis, 35-40 parts of cinnamon, 25-30 parts of Asarum, 15-30 parts of dried peppers, 5- 15 servings;

Step 2, carry out distillation with water vapor by weighing the angelica, cinnamon, asarum, dried pepper, mint, extract volatile oil for later use, and dry the distilled angelica, cinnamon, asarum, dried pepper, peppermint dregs for drying or drying. drying for use;

Step 3, take by weighing 25-30 parts of Cynomorium, 10-15 parts of Mutong, 25-30 parts of Paeonia lactiflora by weight in the above-mentioned traditional Chinese medicine preparation formula for the treatment of osteoarthropathy, after drying or drying in the same step 2 The dregs of angelica, cinnamon, asarum, dried chili, and mint are combined, then decocted with water, and the decoction is extracted for use;

Step 4. Weigh 10-15 parts of wild watermelon (Polik fruit) according to the parts by weight in the above-mentioned traditional Chinese medicine formulation for the treatment of osteoarthritis and pulverize, and use methanol as the extraction solution. The components of volatile oil, flavonoids, alkaloids and other compounds are extracted, the concentration of methanol extract is 90%, the extraction temperature is 80 ℃, and the extraction time is 35-40min;

Step 5. Concentrate the wild watermelon extract and borneol extracted in step 4 and the decoction after decoction in step 3 into 0.2g/ml thick extract, and mix the thick extract and blank matrix in a ratio of (1:1) Mixing (the blank matrix is composed of vaseline and lanolin in a ratio of 2:1), when mixing, heat and melt vaseline and lanolin in a water bath in a ratio of 2:1, add the above mixture at about 65 ° C, mix well, and finally add the steps The volatile oil extracted in No. 2 is evenly stirred to obtain the finished product of the traditional Chinese medicine preparation.

In step 2, the weighed angelica, cinnamon, asarum, dried pepper and mint are soaked in water for 1-3 hours, add 10-12 times the amount of water, extract by steam distillation to obtain volatile oil, and dry the medicinal residues with Cynomorium (Yermaidi Ke), Mutong and Paeonia lactiflora that were weighed in step 3 were combined and soaked for 1-2 hours, decocted and extracted with 8-12 times of water, and kept at a slight boil for 1-1.5 hours after boiling. The first time, filtered while hot, rapidly cooled and combined the filtrate, then centrifuged to remove impurities, extracted the supernatant, and concentrated under reduced pressure (temperature < 50 °C) to an extract of 0.2 g/ml.

Embodiment 2, the traditional Chinese medicine raw materials are proportioned according to the following weight ratios: 400 grams of Angelica sinensis, 400 grams of cinnamon, 300 grams of Cynomorium (Yermaidi gram), 300 grams of Asarum, 150 grams of Mutong, 300 grams of Paeonia lactiflora, Radix Paeoniae Alba 100 grams of watermelon (Polik fruit), 200 grams of dried peppers, 75 grams of mint, and 15 grams of borneol.

The present invention also includes a preparation process of the above-mentioned traditional Chinese medicine preparation for the treatment of osteoarthropathy, comprising the following steps:

Step 1, take by weighing respectively 400 grams of Angelica sinensis, 400 grams of cinnamon, 300 grams of Asarum, 200 grams of dried chili peppers, and 75 grams of mint according to the parts by weight in the above-mentioned traditional Chinese medicine formulation for the treatment of osteoarthropathy;

Step 2, carry out distillation with water vapor by weighing the angelica, cinnamon, asarum, dried pepper, mint, extract volatile oil for later use, and dry the distilled angelica, cinnamon, asarum, dried pepper, peppermint dregs for drying or drying. drying for use;

Step 3, take by weighing 300 grams of Cynomorium, 150 grams of Mutong, 300 grams of Paeonia lactiflora by weight in the above-mentioned traditional Chinese medicine preparation formula for the treatment of osteoarthropathy, with the angelica, cinnamon, rhizome after drying or drying in the same step 2. The pungent, dried chili and mint dregs are combined, then decocted with water, and the decoction is extracted for use;

Step 4, take by weighing 100 grams of wild watermelon (Polik fruit) according to the parts by weight in the above-mentioned traditional Chinese medicine formulation for the treatment of osteoarthritis, and pulverize, use methanol as an extract, and use ultrasonic waves to treat the main component volatile oil of wild watermelon. The concentration of methanol extract was 90%, the extraction temperature was 80 °C, and the extraction time was 40 min;

Step 5. Concentrate the wild watermelon extract and borneol extracted in step 4 and the decoction after decoction in step 3 into 0.2g/ml thick extract, and mix the thick extract and blank matrix in a ratio of (1:1) Mixing (the blank matrix is composed of vaseline and lanolin in a ratio of 2:1), when mixing, heat and melt vaseline and lanolin in a water bath in a ratio of 2:1, add the above mixture at about 65 ° C, mix well, and finally add the steps The volatile oil extracted in No. 2 is evenly stirred to obtain the finished product of the traditional Chinese medicine preparation.

In step 2, soak the weighed angelica, cinnamon, asarum, dried chilli and mint in water for 2 hours, add 12 times the amount of water, extract by steam distillation to obtain volatile oil, dry the medicinal residues and weigh in step 3 Take Cynomorium (Yermaidi Ke), Mutong and Paeonia lactiflora and soak them for 1 hour, add 10 times of water to decoct and extract, keep slightly boiling for 80 minutes after boiling, extract twice, filter while hot, cool quickly and combine The filtrate was then centrifuged (12000 r/min, 15 min) to remove impurities, and the supernatant was extracted and concentrated under reduced pressure (temperature < 50 °C) to an extract of 0.2 g/ml.

Embodiment 3, the traditional Chinese medicine raw material is proportioned according to the following parts by weight: 350 grams of Angelica sinensis, 350 grams of cinnamon, 250 grams of Cynomorium (also Ermaidi grams), 250 grams of Asarum, 100 grams of Mutong, 250 grams of Paeonia lactiflora, Wild watermelon (Polik fruit) 150g, dried chili 250g, mint 100g, borneol 15g.

Step 1, take by weighing respectively 350 grams of Angelica sinensis, 350 grams of cinnamon, 250 grams of Asarum, 250 grams of dried chili peppers, 100 grams of mint by weight in the above-mentioned traditional Chinese medicine formulation for the treatment of osteoarthropathy;

Step 2, carry out distillation with water vapor by weighing the angelica, cinnamon, asarum, dried pepper, mint, extract volatile oil for later use, and dry the distilled angelica, cinnamon, asarum, dried pepper, peppermint dregs for drying or drying. drying for use;

Step 3, take by weighing 250 grams of Cynomorium, 100 grams of Mutong, 250 grams of Paeonia lactiflora by the parts by weight in the above-mentioned traditional Chinese medicine formulation for the treatment of osteoarthropathy, in the same step 2, the angelica, cinnamon, rhizome after drying or drying. The pungent, dried chili and mint dregs are combined, then decocted with water, and the decoction is extracted for use;

Step 4, take by weighing 150 grams of wild watermelon (Polik fruit) according to the parts by weight in the above-mentioned traditional Chinese medicine formulation for the treatment of osteoarthritis, and pulverize, use methanol as an extract, and adopt ultrasonic wave method to the main component volatile oil of wild watermelon. The concentration of methanol extract was 90%, the extraction temperature was 80 °C, and the extraction time was 35 min. The extracts were combined and concentrated under reduced pressure to a relative density of 1:2.9~1:3 (90℃);

Step 5. Concentrate the wild watermelon extract and borneol extracted in step 4 and the decoction after decoction in step 3 into 0.2g/ml thick extract, and mix the thick extract and blank matrix in a ratio of (1:1) Mixing (the blank matrix is composed of vaseline and lanolin in a ratio of 2:1), when mixing, heat and melt vaseline and lanolin in a water bath in a ratio of 2:1, add the above mixture at about 65 ° C, mix well, and finally add the steps The volatile oil extracted in No. 2 is evenly stirred to obtain the finished product of the traditional Chinese medicine preparation.

In step 2, soak the weighed angelica, cinnamon, asarum, dried chilli and mint in water for 2 hours, add 10 times the amount of water, extract by steam distillation to obtain volatile oil, dry the medicinal residues and weigh in step 3 Take Cynomorium (Yermaidi Ke), Mutong, and Paeonia lactiflora and soak them for 1.5 hours, add 10 times of water to decoct and extract, keep slightly boiling for 90 minutes after boiling, extract twice, filter while hot, cool quickly and combine The filtrate was then centrifuged (12000 r/min, 15 min) to remove impurities, and the supernatant was extracted and concentrated under reduced pressure (temperature < 50 °C) to an extract of 0.2 g/ml.

Claims (8)

1. a traditional Chinese medicine formulation for the treatment of osteoarthritis, is characterized in that, raw material of traditional Chinese medicine is proportioned by following parts by weight: Angelica 35-40 parts, cinnamon 35-40 parts, Cynomorium (also Ermaidi gram) 25 parts -30 parts, 25-30 parts of Asarum, 10-15 parts of Mutong, 25-30 parts of Paeonia lactiflora, 10-15 parts of Wild Watermelon (Polik Fruit), 15-30 parts of Dried Chili, 5-15 parts of Mint , borneol 1.0-1.5 copies. 2. a kind of Chinese medicine preparation formula for the treatment of osteoarthropathy as claimed in claim 1, is characterized in that, Chinese medicine raw material is proportioned according to following parts by weight: 40 parts of Angelica sinensis, 40 parts of cinnamon, Cynomorium gram) 30 parts, 30 parts Asarum, 15 parts Mutong, 30 parts white peony root, 10 parts wild watermelon (Polik fruit), 20 parts dry pepper, 7.5 parts mint, 1.5 parts borneol. 3. a kind of traditional Chinese medicine formulation for the treatment of osteoarthropathy as claimed in claim 1, is characterized in that, Chinese medicine raw material is proportioned by following parts by weight: 35 parts of Angelica sinensis, 35 parts of cinnamon, Cynomorium gram) 25 parts, 25 parts Asarum, 10 parts Mutong, 25 parts white peony root, 15 parts wild watermelon (Polik fruit), 25 parts dry pepper, 10 parts mint, 1.5 parts borneol. 4. the preparation technology of a kind of Chinese medicine preparation for the treatment of osteoarthropathy as claimed in claim 1, is characterized in that, comprises the following steps: Step 1, take by weighing the parts by weight in the above-mentioned traditional Chinese medicine formulation for the treatment of osteoarthritis, respectively Angelica sinensis, cinnamon, Asarum, dried chili pepper, mint; Step 2, carry out distillation with water vapor by weighing the angelica, cinnamon, asarum, dried pepper, mint, extract volatile oil for later use, and dry the distilled angelica, cinnamon, asarum, dried pepper, peppermint dregs for drying or drying. drying for use; Step 3, take by weighing Cynomorium, Mutong, Paeonia lactiflora by weight in the above-mentioned traditional Chinese medicine formulation for the treatment of osteoarthritis, with the angelica, cinnamon, Asarum, dried chili, mint after drying or drying in the same step 2 The medicinal residues are combined, then decocted with water, and the decoction is extracted for use; Step 4, take by weighing the wild watermelon (Polik fruit) and pulverize according to the parts by weight in the above-mentioned traditional Chinese medicine formulation for the treatment of osteoarthropathy, use methanol as the extraction solution, and adopt the ultrasonic method to treat the main components of the wild watermelon volatile oil, volatile oil, Extract flavonoids, alkaloids and other compounds; Step 5. Concentrate the wild watermelon extract and borneol extracted in step 4 and the decoction after decoction in step 3 to form a thick extract, and then mix the thick extract with a blank base (the blank base is mixed with vaseline and lanolin) composition), and finally adding the volatile oil extracted in step 2 and stirring evenly to obtain the finished Chinese medicine preparation. 5. the preparation technology of a kind of traditional Chinese medicine preparation for the treatment of osteoarthropathy as claimed in claim 4, is characterized in that, in step 5, by the wild watermelon extract extracted in step 4 and the decoction after decoction in step 3 Concentrate and combine into 0.2g/ml thick extract, mix the thick extract and blank base in a ratio of (1:1) (blank base is composed of vaseline and lanolin in a ratio of 2:1). 6. the preparation technique of a kind of traditional Chinese medicine preparation for the treatment of osteoarthropathy as claimed in claim 5, it is characterised in that in step 5, vaseline, lanolin are heated and melted in a water bath at a ratio of 2:1, at about 65 ℃ Add the above mixture and mix. 7. the preparation technology of a kind of traditional Chinese medicine preparation for the treatment of osteoarthropathy as claimed in claim 4, is characterized in that, in step 2, will take by weighing the angelica, cinnamon, asarum, dried chili, peppermint water soak 1- For 3 hours, add 10-12 times the amount of water, extract by steam distillation to obtain volatile oil, dry the dregs in the sun, and soak them together with the Cynomorium (Yermaidi Ke), Mutong and Paeonia lactiflora weighed in step 3 for 1 -2 hours, add 8-12 times of water to decoct and extract, keep slightly boiling for 1-1.5 hours after boiling, extract twice, filter while hot, cool quickly and combine the filtrates, then centrifuge to remove impurities, extract the supernatant, reduce The extract was concentrated under pressure (temperature < 50°C) to 0.2 g/ml. 8. the preparation technique of a kind of traditional Chinese medicine preparation for the treatment of osteoarthropathy as claimed in claim 4, it is characterised in that in step 4, the wild watermelon (Polik fruit) is powdered, and the component extraction is carried out with the help of ultrasonic waves : The concentration of methanol extract is 90%, the extraction temperature is 80 ℃, and the extraction time is 35-40min.

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