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CN111989311A - 抑制pge2/ep4信号传导的化合物、其制备方法及其在医药上的应用 - Google Patents

抑制pge2/ep4信号传导的化合物、其制备方法及其在医药上的应用 Download PDF

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CN111989311A
CN111989311A CN202080002090.1A CN202080002090A CN111989311A CN 111989311 A CN111989311 A CN 111989311A CN 202080002090 A CN202080002090 A CN 202080002090A CN 111989311 A CN111989311 A CN 111989311A
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alkoxy
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halo
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CN111989311B (zh
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邓永奇
孙健
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Kaifu Suzhou Biomedical Co ltd
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Abstract

一种通式(I)所示的化合物、其制备方法及含有该衍生物的药物组合物以及其作为治疗剂，特别是作为PGE2/EP4信号传导抑制剂的用途以及用于治疗癌症、急性或慢性疼痛、偏头痛、骨关节炎、类风湿性关节炎、痛风、粘液囊炎、强直性脊柱炎、原发性痛经、癌症或动脉硬化症的用途。

Description

PCT国内申请，说明书已公开。

Claims (15)

  1. PCT国内申请，权利要求书已公开。
CN202080002090.1A 2019-01-22 2020-01-16 抑制pge2/ep4信号传导的化合物、其制备方法及其在医药上的应用 Active CN111989311B (zh)

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CN2019100575552 2019-01-22
CN201910057555 2019-01-22
PCT/CN2020/072487 WO2020151566A1 (zh) 2019-01-22 2020-01-16 抑制pge2/ep4信号传导的化合物、其制备方法及其在医药上的应用

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US (1) US12240812B2 (zh)
EP (1) EP3889134B1 (zh)
JP (1) JP7488269B2 (zh)
KR (1) KR20210117280A (zh)
CN (1) CN111989311B (zh)
AU (1) AU2020212111B2 (zh)
CA (1) CA3126484A1 (zh)
ES (1) ES2995259T3 (zh)
TW (1) TWI865480B (zh)
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JP2022536607A (ja) * 2019-06-11 2022-08-18 テオン セラピューティクス，インク． プロスタグランジンｅ２受容体４アンタゴニスト及びその使用
US20230390303A1 (en) 2020-11-13 2023-12-07 Ono Pharmaceutical Co., Ltd. Cancer treatment by combination of ep4 antagonist and immune checkpoint inhibitor
CN112608271A (zh) * 2020-11-26 2021-04-06 安润医药科技（苏州）有限公司 酰胺衍生物及其在制备ep4受体拮抗剂中的应用
CN117377471A (zh) * 2021-05-28 2024-01-09 凯复(苏州)生物医药有限公司 治疗肿瘤的联合疗法
CN115448882A (zh) * 2021-06-08 2022-12-09 武汉人福创新药物研发中心有限公司 用于治疗ep2、ep4受体介导的疾病的苯并杂环化合物
US20240294511A1 (en) * 2021-08-27 2024-09-05 Keythera (Suzhou) Bio-Pharmaceuticals Co., Limited Solid form of indole compound, preparation method therefor and use thereof
CN119013017A (zh) * 2022-02-15 2024-11-22 治纳辅医药科技有限公司 包含抗癌剂和对前列腺素e2受体具有抑制活性的新化合物的用于治疗癌症的药物组合物
JP2025508475A (ja) * 2022-02-24 2025-03-26 クヮントン ニューオップ バイオファーマシューティカルズ カンパニー， リミテッド プロスタグランジンｅ２（ｐｇｅ２）受容体拮抗剤としてのアミド化合物
CN114591137B (zh) * 2022-05-10 2022-09-09 上海赛默罗生物科技有限公司 螺桨烷类衍生物的合成方法

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CN101622230A (zh) * 2007-02-26 2010-01-06 默克弗罗斯特加拿大有限公司 作为ep4受体拮抗剂的吲哚和二氢吲哚环丙基酰胺衍生物
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CN105793236A (zh) * 2013-12-17 2016-07-20 伊莱利利公司 二甲基苯甲酸化合物
WO2018195123A1 (en) * 2017-04-18 2018-10-25 Tempest Therapeutics, Inc. Bicyclic compounds and their use in the treatment of cancer

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TW202041498A (zh) 2020-11-16
AU2020212111A1 (en) 2021-08-05
WO2020151566A1 (zh) 2020-07-30
CN111989311B (zh) 2022-03-22
US20220064113A1 (en) 2022-03-03
KR20210117280A (ko) 2021-09-28
AU2020212111B2 (en) 2025-01-23
EP3889134B1 (en) 2024-09-25
JP7488269B2 (ja) 2024-05-21
JP2022522993A (ja) 2022-04-21
ES2995259T3 (en) 2025-02-10
EP3889134A4 (en) 2022-02-16
EP3889134C0 (en) 2024-09-25
EP3889134A1 (en) 2021-10-06
TWI865480B (zh) 2024-12-11
US12240812B2 (en) 2025-03-04
CA3126484A1 (en) 2020-07-30

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