CN111938639A - Device for detecting injury degree and range of organism soft tissue based on electrical impedance method - Google Patents
Device for detecting injury degree and range of organism soft tissue based on electrical impedance method Download PDFInfo
- Publication number
- CN111938639A CN111938639A CN202010647729.3A CN202010647729A CN111938639A CN 111938639 A CN111938639 A CN 111938639A CN 202010647729 A CN202010647729 A CN 202010647729A CN 111938639 A CN111938639 A CN 111938639A
- Authority
- CN
- China
- Prior art keywords
- electrode plate
- measuring
- grid electrode
- degree
- detecting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract description 45
- 210000004872 soft tissue Anatomy 0.000 title claims abstract description 45
- 230000006378 damage Effects 0.000 title claims abstract description 43
- 208000014674 injury Diseases 0.000 title claims description 19
- 208000027418 Wounds and injury Diseases 0.000 title claims description 13
- 239000000463 material Substances 0.000 claims description 6
- 230000000451 tissue damage Effects 0.000 abstract description 25
- 231100000827 tissue damage Toxicity 0.000 abstract description 25
- 238000001514 detection method Methods 0.000 abstract description 24
- 238000003745 diagnosis Methods 0.000 abstract description 5
- 238000007920 subcutaneous administration Methods 0.000 abstract description 4
- 238000005259 measurement Methods 0.000 description 34
- 210000001519 tissue Anatomy 0.000 description 23
- 230000003902 lesion Effects 0.000 description 11
- 230000008733 trauma Effects 0.000 description 8
- 208000024891 symptom Diseases 0.000 description 7
- 208000026137 Soft tissue injury Diseases 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 150000002500 ions Chemical class 0.000 description 4
- 230000008961 swelling Effects 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 210000002977 intracellular fluid Anatomy 0.000 description 3
- 238000002559 palpation Methods 0.000 description 3
- 206010037660 Pyrexia Diseases 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000003722 extracellular fluid Anatomy 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 230000001953 sensory effect Effects 0.000 description 2
- 230000037380 skin damage Effects 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 238000002565 electrocardiography Methods 0.000 description 1
- 210000003195 fascia Anatomy 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 230000006996 mental state Effects 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Radiology & Medical Imaging (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Abstract
本发明公开了一种基于电阻抗法检测机体软组织损伤程度和范围的装置,解决了现有技术对皮下软组织损伤缺乏有效手段快速检测,存在误诊漏诊可能性的技术问题。本发明的装置包括电导率仪、至少两个测量电极、连接线和网格电极板,网格电极板为中空结构,网格电极板的各边上分别设置有多个用于放置测量电极的网孔,测量电极放置于网孔内并与待检测的皮肤贴合,测量电极经连接线与电导率仪连接,并通过电导率仪检测出两个测量电极之间的电导率。本发明的装置可测得皮肤域上不同位置之间的电导率,为确定机体软组织损伤程度和范围提供数字依据,减少了医生主观判断对结果的影响,从而可提高检测结果的准确性。
The invention discloses a device for detecting the degree and scope of soft tissue damage in a body based on an electrical impedance method, which solves the technical problems that the prior art lacks effective means for rapid detection of subcutaneous soft tissue damage and has the possibility of misdiagnosis and missed diagnosis. The device of the present invention includes a conductivity meter, at least two measuring electrodes, connecting wires and a grid electrode plate. The grid electrode plate is a hollow structure, and each side of the grid electrode plate is respectively provided with a plurality of electrodes for placing the measuring electrodes. Mesh, the measuring electrode is placed in the mesh and is attached to the skin to be tested, the measuring electrode is connected with the conductivity meter through the connecting wire, and the conductivity between the two measuring electrodes is detected by the conductivity meter. The device of the invention can measure the electrical conductivity between different positions on the skin area, provides a digital basis for determining the damage degree and scope of the soft tissue of the body, reduces the influence of the doctor's subjective judgment on the result, and can improve the accuracy of the detection result.
Description
技术领域technical field
本发明涉及临床医学诊断检测设备技术领域,尤其涉及一种基于电阻抗法检测机体软组织损伤程度和范围的装置。The invention relates to the technical field of clinical medical diagnosis and detection equipment, in particular to a device for detecting the degree and scope of damage to soft tissue of a body based on an electrical impedance method.
背景技术Background technique
软组织损伤是指人体的肌肉、筋膜、肌腱、韧带、腱鞘、滑囊、血管、神经等组织。这些组织受到外来暴力的突然打击、牵拉、扭转、重力压迫,或外伤造成的局部细菌感染等,造成的损伤即为软组织损伤。软组织受创后出现微循环障碍和炎症,致使局部皮肤组织红、肿、热、痛和功能障碍等。目前临床常用局部软组织损伤范围及严重程度检查方法是根据临床症状来判断,主要观察以下三个方面:Soft tissue injury refers to the human body's muscles, fascia, tendons, ligaments, tendon sheaths, bursae, blood vessels, nerves and other tissues. These tissues are suddenly hit, pulled, twisted, compressed by gravity, or local bacterial infection caused by trauma, and the damage caused is soft tissue damage. Microcirculation disturbance and inflammation occur after soft tissue trauma, resulting in local skin tissue redness, swelling, heat, pain and dysfunction. At present, the commonly used clinical methods to check the scope and severity of local soft tissue injury are based on clinical symptoms. The following three aspects are mainly observed:
(1)局部检查:以局部皮肤红肿热痛症状和皮肤表面破损情况找出病灶部位,根据感官检查(视诊、触诊)方式大致判断预估病灶范围。(1) Local examination: Find the lesion site based on the symptoms of local skin redness, swelling, heat and pain and skin surface damage, and roughly judge the estimated lesion range according to sensory examination (inspection and palpation).
(2)查询病史:询问发病时间、地点、经过、创伤形成原因、自感等。(2) Inquiry of medical history: inquire about the onset time, location, process, cause of trauma, self-perception, etc.
(3)全身检查:观察有无发热、心率改变、精神状态等。(3) General examination: observe whether there is fever, changes in heart rate, mental state, etc.
通过上述方法虽然可以检测出软组织损伤程度和范围,但是检测结果主要依赖于医生的临床判断,缺乏统一的标准。对于同样的症状,不同的医生得出的结论可能存在差异,存在误差。Although the degree and scope of soft tissue damage can be detected by the above methods, the detection results mainly depend on the clinical judgment of doctors and lack a unified standard. For the same symptoms, the conclusions drawn by different doctors may be different, and there may be errors.
由于生物组织细胞的导电性与组织中各种离子浓度、蛋白质量、组织含水量、组织细胞的完整性、温度等因素相关。正常组织上述的因素相对恒定,所以导电性也相对恒定,或者变化很小。如因创伤炎症等因素对局部组织细胞造成损伤,就会改变上述内环境,其中离子浓度变化影响最大,正常组织细胞内液和细胞外液各种离子浓度分布是相对恒定的,细胞内液离子的移动性因细胞膜而受限。正常电导率主要反映细胞外液离子情况,如创伤炎症等破坏了细胞完整性,则细胞内液流出,造成局部组织导电性增加,即电阻抗有减少的趋势,损伤越重,细胞破坏越多,细胞内液流出越多,电阻抗减少的趋势也越明显。因此,可基于组织电阻抗的变化趋势进行损伤部位范围和损伤程度的判断。Because the electrical conductivity of biological tissue cells is related to various ion concentrations in the tissue, the amount of protein, the water content of the tissue, the integrity of the tissue cells, and the temperature. In normal tissue, the above factors are relatively constant, so the conductivity is relatively constant, or varies little. If the local tissue cells are damaged due to factors such as trauma and inflammation, the above-mentioned internal environment will be changed. Among them, the change of ion concentration has the greatest impact. The distribution of various ion concentrations in the intracellular fluid and extracellular fluid of normal tissues is relatively constant. Mobility is limited by the cell membrane. The normal conductivity mainly reflects the ions in the extracellular fluid. If the cell integrity is damaged by trauma and inflammation, the intracellular fluid flows out, resulting in an increase in the electrical conductivity of the local tissue, that is, the electrical impedance tends to decrease. The heavier the damage, the more cell damage. , the more the intracellular fluid flows out, the more obvious the tendency of electrical impedance to decrease. Therefore, the damage site range and damage degree can be judged based on the change trend of the electrical impedance of the tissue.
然而,现有技术中缺乏相应的装置,因此,急需提供一种基于电阻抗法检测机体软组织损伤程度和范围的装置。However, there is a lack of corresponding devices in the prior art. Therefore, there is an urgent need to provide a device for detecting the degree and scope of soft tissue damage in the body based on the electrical impedance method.
发明内容SUMMARY OF THE INVENTION
本发明的其中一个目的是提出一种基于电阻抗法检测机体软组织损伤程度和范围的装置,解决了现有技术中临床医生仅能根据观察和触诊患者软组织判断损伤程度和范围,对皮下软组织损伤缺乏有效手段快速检测,存在误诊漏诊可能性的技术问题。本发明优选技术方案所能产生的诸多技术效果详见下文阐述。One of the purposes of the present invention is to propose a device for detecting the degree and scope of soft tissue damage in the body based on electrical impedance method, which solves the problem in the prior art that clinicians can only judge the degree and scope of damage based on observation and palpation of the patient's soft tissue, and can detect the damage degree and scope of the subcutaneous soft tissue. There is no effective means for rapid detection of damage, and there is a technical problem of the possibility of misdiagnosis and missed diagnosis. The technical effects that can be produced by the preferred technical solutions of the present invention are described in detail below.
为实现上述目的,本发明提供了以下技术方案:For achieving the above object, the invention provides the following technical solutions:
本发明基于电阻抗法检测机体软组织损伤程度和范围的装置,包括电导率仪、至少两个测量电极、连接线和网格电极板,其中,所述网格电极板为中空结构,所述网格电极板的各边上分别设置有多个用于放置测量电极的网孔,所述测量电极放置于所述网孔内并与待检测的皮肤贴合,所述测量电极经所述连接线与所述电导率仪连接,并通过所述电导率仪检测出两个所述测量电极之间的电导率。The device of the present invention for detecting the degree and scope of soft tissue damage in the body based on the electrical impedance method includes a conductivity meter, at least two measuring electrodes, a connecting wire and a grid electrode plate, wherein the grid electrode plate is a hollow structure, and the grid electrode plate is a hollow structure. Each side of the grid electrode plate is provided with a plurality of mesh holes for placing measuring electrodes, the measuring electrodes are placed in the mesh holes and are attached to the skin to be detected, and the measuring electrodes are connected through the connecting wire. It is connected with the conductivity meter, and the conductivity between the two measuring electrodes is detected by the conductivity meter.
根据一个优选实施方式,所述测量电极的数量为两个。According to a preferred embodiment, the number of the measuring electrodes is two.
根据一个优选实施方式,所述测量电极的数量为N个,N为大于等于4的偶数,N个所述测量电极均分为N/2组,并且所述装置还包括测量电极线转换开关,所述测量电极经所述测量电极线转换开关与所述电导率仪连接,并通过所述测量电极线转换开关切换每组所述测量电极的工作状态。According to a preferred embodiment, the number of the measurement electrodes is N, N is an even number greater than or equal to 4, the N measurement electrodes are equally divided into N/2 groups, and the device further includes a measurement electrode line switch, The measurement electrodes are connected to the conductivity meter through the measurement electrode line changeover switch, and the working state of each group of the measurement electrodes is switched through the measurement electrode line changeover switch.
根据一个优选实施方式,所述测量电极为圆形结构,并且所述测量电极的直径为6~15mm;所述测量电极与待检测皮肤贴合的一侧设置有导电糊层。According to a preferred embodiment, the measuring electrode is a circular structure, and the diameter of the measuring electrode is 6-15 mm; a conductive paste layer is provided on the side of the measuring electrode that is attached to the skin to be detected.
根据一个优选实施方式,所述网格电极板使用可弯曲材料制成,以使所述网格电极板放置于待检测皮肤上能够与待检测皮肤贴合。According to a preferred embodiment, the grid electrode plate is made of a bendable material, so that the grid electrode plate is placed on the skin to be tested and can fit with the skin to be tested.
根据一个优选实施方式,所述网格电极板上的网孔为正方形结构,并且所述网孔的边长与所述测量电极的直径相当,以使所述测量电极放置于所述网孔中后,所述测量电极能够固定并且所述测量电极的中心与所述网孔的中心彼此重合。According to a preferred embodiment, the mesh holes on the grid electrode plate are of a square structure, and the side length of the mesh holes is equivalent to the diameter of the measuring electrodes, so that the measuring electrodes are placed in the mesh holes Afterwards, the measuring electrode can be fixed and the center of the measuring electrode and the center of the mesh are coincident with each other.
根据一个优选实施方式,所述网格电极板上相邻两个所述网孔中心之间的距离相等,并且相邻两个所述网孔中心之间的距离为0.5~2cm。According to a preferred embodiment, the distance between the centers of two adjacent mesh holes on the grid electrode plate is equal, and the distance between the centers of two adjacent mesh holes is 0.5-2 cm.
根据一个优选实施方式,所述网格电极板的尺寸大于预估创伤病灶边缘 2~6cm。According to a preferred embodiment, the size of the grid electrode plate is 2-6 cm larger than the estimated edge of the trauma lesion.
根据一个优选实施方式,所述网格电极板为方形结构,并且所述网格电极板的规格为9~15cm*9~15cm。According to a preferred embodiment, the grid electrode plate has a square structure, and the size of the grid electrode plate is 9-15cm*9-15cm.
根据一个优选实施方式,所述的基于电阻抗法检测机体软组织损伤程度和范围的装置还包括数据处理器,所述数据处理器与所述电导率仪连接,并且所述电导率仪将检测到的数据发送给所述数据处理器,以通过所述数据处理器对所述电导率仪检测到的数据进行分析处理。According to a preferred embodiment, the device for detecting the degree and extent of soft tissue damage in the body based on the electrical impedance method further comprises a data processor, the data processor is connected to the conductivity meter, and the conductivity meter detects the The data is sent to the data processor, so that the data detected by the conductivity meter can be analyzed and processed by the data processor.
本发明提供的基于电阻抗法检测机体软组织损伤程度和范围的装置至少具有如下有益技术效果:The device for detecting the degree and scope of soft tissue damage in the body based on the electrical impedance method provided by the present invention has at least the following beneficial technical effects:
本发明基于电阻抗法检测机体软组织损伤程度和范围的装置包括电导率仪、至少两个测量电极、连接线和网格电极板,其中,网格电极板为中空结构,网格电极板的各边上分别设置有多个用于放置测量电极的网孔,测量电极放置于网孔内并与待检测的皮肤贴合,测量电极经连接线与电导率仪连接,并通过电导率仪检测出两个测量电极之间的电导率,即通过本发明的装置,可测得两个测量电极之间的电导率,基于所测得的皮肤域上不同位置之间的电导率大小,可为确定机体软组织损伤程度和范围提供数字依据,从而使得医生判断机体软组织损伤程度和范围有了固定的标准,减少了医生主观判断对结果的影响,对于同样的症状,不同的医生基于测量数据得出的结论应当是一致的,大大提高检测结果的准确性。The device of the present invention for detecting the degree and range of soft tissue damage in the body based on the electrical impedance method includes a conductivity meter, at least two measuring electrodes, a connecting wire and a grid electrode plate, wherein the grid electrode plate is a hollow structure, and each of the grid electrode plates has a hollow structure. There are a plurality of mesh holes for placing the measuring electrodes on the sides. The measuring electrodes are placed in the mesh holes and fit with the skin to be tested. The measuring electrodes are connected with the conductivity meter through the connecting wire, and the conductivity meter detects The electrical conductivity between the two measuring electrodes, that is, through the device of the present invention, the electrical conductivity between the two measuring electrodes can be measured, and based on the measured electrical conductivity between different positions on the skin area, it can be determined. The degree and scope of soft tissue damage in the body provide a numerical basis, so that doctors have a fixed standard for judging the degree and scope of soft tissue damage in the body, reducing the influence of doctors’ subjective judgment on the results. For the same symptoms, different doctors based on measurement data. The conclusions should be consistent, greatly improving the accuracy of the test results.
即本发明通过基于电阻抗法检测机体软组织损伤程度和范围的装置检测皮肤域上不同位置之间的电导率,解决了现有技术中临床医生仅能根据观察和触诊患者软组织判断损伤程度和范围,对皮下软组织损伤缺乏有效手段快速检测,存在误诊漏诊可能性的技术问题。That is to say, the present invention detects the electrical conductivity between different positions on the skin domain through a device based on the electrical impedance method for detecting the damage degree and range of the soft tissue of the body, which solves the problem that in the prior art, the clinician can only judge the degree of damage and palpation of the soft tissue of the patient. There is a lack of effective means for rapid detection of subcutaneous soft tissue injury, and there is a technical problem of the possibility of misdiagnosis and missed diagnosis.
附图说明Description of drawings
为了更清楚地说明本发明实施例或现有技术中的技术方案,下面将对实施例或现有技术描述中所需要使用的附图作简单地介绍,显而易见地,下面描述中的附图仅仅是本发明的一些实施例,对于本领域普通技术人员来讲,在不付出创造性劳动的前提下,还可以根据这些附图获得其他的附图。In order to explain the embodiments of the present invention or the technical solutions in the prior art more clearly, the following briefly introduces the accompanying drawings that need to be used in the description of the embodiments or the prior art. Obviously, the accompanying drawings in the following description are only These are some embodiments of the present invention. For those of ordinary skill in the art, other drawings can also be obtained according to these drawings without creative efforts.
图1是本发明基于电阻抗法检测机体软组织损伤程度和范围的装置的一个优选实施方式框图;FIG. 1 is a block diagram of a preferred embodiment of the device for detecting the degree and scope of soft tissue damage in the body based on the electrical impedance method of the present invention;
图2是确定的测量点的网格电极板的一个优选实施方式示意图。FIG. 2 is a schematic diagram of a preferred embodiment of a grid electrode plate for determining measurement points.
图中:1、电导率仪;11、温度补偿传感器;2、测量电极;3、连接线;4、网格电极板;41、网孔;5、测量电极线转换开关;6、数据处理器。In the figure: 1. Conductivity meter; 11. Temperature compensation sensor; 2. Measuring electrode; 3. Connecting wire; 4. Grid electrode plate; 41. Mesh; 5. Measuring electrode wire switch; 6. Data processor .
具体实施方式Detailed ways
为使本发明的目的、技术方案和优点更加清楚,下面将对本发明的技术方案进行详细的描述。显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动的前提下所得到的所有其它实施方式,都属于本发明所保护的范围。In order to make the objectives, technical solutions and advantages of the present invention clearer, the technical solutions of the present invention will be described in detail below. Obviously, the described embodiments are only some, but not all, embodiments of the present invention. Based on the embodiments of the present invention, all other implementations obtained by those of ordinary skill in the art without creative work fall within the protection scope of the present invention.
下面结合说明书附图1和2以及实施例1和2对本发明基于电阻抗法检测机体软组织损伤程度和范围的装置进行详细说明。The device for detecting the degree and scope of soft tissue damage in the body based on the electrical impedance method of the present invention will be described in detail below with reference to Figures 1 and 2 and Embodiments 1 and 2 of the description.
电导率是物体传导电流的能力,在两测量电极2上施加一定正弦波电势,测量电极2之间流过的电流。根据欧姆定律,电导率G是电阻率R的倒数,即 G=1/R。电导率值越大电阻值越小。本实施例优选技术方案基于电阻抗法检测机体软组织损伤程度和范围的装置,通过电导率仪1可测得两个测量电极2之间的电导率,电导率越大,电阻值越小,表明皮肤损伤越严重。Conductivity is the ability of an object to conduct current. A certain sine wave potential is applied to the two measuring
实施例1Example 1
本实施例结合图1和2对本发明基于电阻抗法检测机体软组织损伤程度和范围的装置进行详细说明。In this embodiment, the apparatus for detecting the degree and scope of soft tissue damage in the body based on the electrical impedance method of the present invention is described in detail with reference to FIGS. 1 and 2 .
本实施例基于电阻抗法检测机体软组织损伤程度和范围的装置,包括电导率仪1、至少两个测量电极2、连接线3和网格电极板4,如图1所示。其中,网格电极板4为中空结构,网格电极板4的各边上分别设置有多个用于放置测量电极2的网孔41,测量电极2放置于网孔41内并与待检测的皮肤贴合,测量电极2经连接线3与电导率仪1连接,并通过电导率仪1检测出两个测量电极2之间的电导率,如图1或2所示。例如,测量电极2类似于做心电图用的测量电极。电导率仪1也可以说是阻抗仪,与测量电极2连接,用做检测交流信号源。电导率仪1例如是电导率仪DDS-309型。The apparatus for detecting the degree and scope of soft tissue damage in the body based on the electrical impedance method in this embodiment includes a conductivity meter 1 , at least two measuring
优选的,电导率仪1还具有温度补偿传感器11。由于环境温度改变会影响仪器测量准确性,通过温度补偿可以消除或减少温度改变对检测结果的影响。Preferably, the conductivity meter 1 also has a temperature compensation sensor 11 . Since changes in ambient temperature will affect the measurement accuracy of the instrument, temperature compensation can eliminate or reduce the impact of temperature changes on the test results.
本实施例基于电阻抗法检测机体软组织损伤程度和范围的装置,可测得两个测量电极2之间的电导率,基于所测得的皮肤域上不同位置之间的电导率大小,可为确定机体软组织损伤程度和范围提供数字依据,从而使得医生判断机体软组织损伤程度和范围有了固定的标准,减少了医生主观判断对结果的影响,对于同样的症状,不同的医生基于测量数据得出的结论应当是一致的,大大提高检测结果的准确性。This embodiment is based on a device for detecting the degree and scope of soft tissue damage in the body based on the electrical impedance method. The electrical conductivity between the two measuring
即本实施例通过基于电阻抗法检测机体软组织损伤程度和范围的装置检测皮肤域上不同位置之间的电导率,解决了现有技术中临床医生仅能根据观察和触诊患者软组织判断损伤程度和范围,对皮下软组织损伤缺乏有效手段快速检测,存在误诊漏诊可能性的技术问题。That is, in this embodiment, the electrical conductivity between different positions on the skin domain is detected by the device for detecting the damage degree and range of the soft tissue of the body based on the electrical impedance method, which solves the problem that in the prior art, the clinician can only judge the damage degree by observing and palpating the soft tissue of the patient. There is a lack of effective means for rapid detection of subcutaneous soft tissue injury, and there is a technical problem of the possibility of misdiagnosis and missed diagnosis.
如图2所示,网格电极板4为中空结构,即网格电极板4的中间部位为空心的(虚线部分其实是没有的,为了便于理解,在图中将其以虚线的形式补充出来),仅在网格电极板4的各边上分别设置一排网孔41,避免网格电极板4 的中间部分压到创伤部位,引起患者不适。As shown in FIG. 2 , the
根据一个优选实施方式,测量电极2的数量为两个。两个测量电极2放置于网格电极板4上的不同网孔41处,以检测皮肤上两点之间的电导率。According to a preferred embodiment, the number of measuring
根据一个优选实施方式,测量电极2的数量为N个,N为大于等于4的偶数,N个测量电极2均分为N/2组,并且装置还包括测量电极线转换开关5,测量电极2经测量电极线转换开关5与电导率仪1连接,并通过测量电极线转换开关5切换每组测量电极2的工作状态。According to a preferred embodiment, the number of
例如,测量电极2的数量为四个。四个测量电极2中,分为两组,每组两个,其中一组放置于网格电极板4横向上的不同网孔41内,以检测皮肤横向上两点之间的电导率;另一组放置网格电极板4纵向上的不同网孔41内,以检测皮肤纵向上两点之间的电导率。不同组测量电极2之间可以通过测量电极线转换开关5切换工作状态,以提高检测效率。For example, the number of
又例如,测量电极2的数量与网孔41的数量相匹配,以在每个网孔41内预先安装上测量电极2,如图2所示。测量时,通过测量电极线转换开关5切换每组测量电极2的工作状态,可避免测量过程中再重复安放测量电极2,从而可以提高检测效率。For another example, the number of the measuring
根据一个优选实施方式,测量电极2为圆形结构,并且测量电极2的直径为6~15mm;测量电极2与待检测皮肤贴合的一侧设置有导电糊层。优选的,测量电极2的直径为10mm,采用不锈钢材料制成。测量电极2在使用时,预先在测量电极2与待检测皮肤贴合的一侧涂抹一层导电糊,再将测量电极2按压在待检测皮肤上,与待检测皮肤紧密贴合。According to a preferred embodiment, the measuring
根据一个优选实施方式,网格电极板4使用可弯曲材料制成,以使网格电极板4放置于待检测皮肤上能够与待检测皮肤贴合。可弯曲材料例如是无毒塑胶材料,例如聚乙烯材料。According to a preferred embodiment, the
根据一个优选实施方式,网格电极板4上的网孔41为正方形结构,并且网孔41的边长与测量电极2的直径相当,以使测量电极2放置于网孔41中后,测量电极2能够固定并且测量电极2的中心与网孔41的中心彼此重合,如图2 所示。不限于此,网孔41也可以是其余形状,例如圆形、三角形等。According to a preferred embodiment, the mesh holes 41 on the
本实施例优选技术方案设置网格电极板4,网格电极板4上设置网孔41,一方面便于安放测量电极2,另一方面还可以固定两测量电极2之间的距离。具体的,网孔41的边长与测量电极2的直径相当,可使测量电极2放置于网孔 41中后,测量电极2能够固定并且测量电极2的中心与网孔41的中心彼此重合,便于计算两测量电极2之间的距离。The preferred technical solution of this embodiment is to provide a
根据一个优选实施方式,网格电极板4上相邻两个网孔41中心之间的距离相等,并且相邻两个网孔41中心之间的距离为0.5~2cm。优选的,相邻两个网孔41中心之间的距离为1cm。According to a preferred embodiment, the distance between the centers of two adjacent mesh holes 41 on the
根据一个优选实施方式,网格电极板4的尺寸大于预估创伤病灶边缘2~6cm,如图2所示。优选的,网格电极板4为方形结构,并且网格电极板4 的规格为9~15cm*9~15cm。更优选的,网格电极板4为正方形结构,并且网格电极板4的规格为9cm*9cm、11cm*11cm、13cm*13cm和15cm*15cm中的一种或多种。可知的,网格电极板4的形状不限于此,也可以基于身体各部位的情况设置为弧形结构或与身体部位相匹配的结构。网格电极板4的规格也可以设置为更大或更小的尺寸。According to a preferred embodiment, the size of the
根据临床检查初步确定病灶部位,选择适合尺寸的网格电极板4,本实施例优选技术方案的网格电极板4的尺寸大于预估创伤病灶边缘2~6cm,便于准确检测出病灶范围和损伤程度。The location of the lesion is preliminarily determined according to the clinical examination, and the
根据一个优选实施方式,本实施例基于电阻抗法检测机体软组织损伤程度和范围的装置还可包括数据处理器6,如图1所示。优选的,数据处理器6与电导率仪1连接,电导率仪1将检测数据发送给数据处理器6进行数据处理。数据处理器6例如是电脑,具有用于对数据信号实现逻辑功能的逻辑门电路的离散逻辑电路,具有合适的组合逻辑门电路的专用集成电路,可编程门阵列 (PGA),现场可编程门阵列(FPGA)等。According to a preferred embodiment, the apparatus for detecting the degree and extent of soft tissue damage in the body based on the electrical impedance method in this embodiment may further include a data processor 6 , as shown in FIG. 1 . Preferably, the data processor 6 is connected to the conductivity meter 1, and the conductivity meter 1 sends the detection data to the data processor 6 for data processing. The data processor 6 is, for example, a computer, discrete logic circuits with logic gates for implementing logic functions on data signals, application specific integrated circuits with suitable combinational logic gates, programmable gate arrays (PGA), field programmable gates Array (FPGA) etc.
实施例2Example 2
本实施例结合图2对本发明基于电阻抗法检测机体软组织损伤程度和范围的装置的使用方法详细说明。In this embodiment, the method of using the apparatus for detecting the degree and scope of soft tissue damage in the body based on the electrical impedance method of the present invention is described in detail with reference to FIG. 2 .
本实施例基于电阻抗法检测机体软组织损伤程度和范围的装置的使用方法包括如下步骤:The method for using the apparatus for detecting the degree and scope of soft tissue damage in the body based on the electrical impedance method in this embodiment includes the following steps:
S1:确定预估病灶范围。具体的,基于局部皮肤红肿热痛症状和/或皮肤表面破损情况找出病灶部位。更具体的,基于皮肤局部红肿热症症状和/或表面皮肤破损情况,应用眼观、触压等感官检查方式大致判断预估病灶范围。S1: Determine the estimated range of lesions. Specifically, the lesion site is found based on local skin redness, swelling, heat and pain symptoms and/or skin surface damage. More specifically, based on the symptoms of local skin redness, swelling and fever and/or surface skin damage, sensory inspection methods such as visual inspection and tactile pressure are used to roughly determine the estimated range of lesions.
S2:选择合适的网格电极板4。原则上是选择的网格电极板4大于预估病灶边缘2~6cm。在实际使用中,也可基于实际情况选择合适的网格电极板4。S2: Select a suitable
S3:连接基于电阻抗法检测机体软组织损伤程度和范围的装置的各部件。具体的,将测量电极2放置于网格电极板4的网孔41内,将测量电极2经连接线3与电导率仪1连接,通过电导率仪1检测出两个测量电极2之间的电导率。S3: Connect each component of the device for detecting the degree and extent of soft tissue damage in the body based on the electrical impedance method. Specifically, the measuring
下面以大腿外侧中段皮肤实测为例说明本发明基于电阻抗法检测机体软组织损伤程度和范围的装置的使用方法。The following takes the actual measurement of the skin of the outer middle segment of the thigh as an example to illustrate the use method of the device for detecting the damage degree and scope of the soft tissue of the body based on the electrical impedance method of the present invention.
使用9cm*9cm的网格电极板4。如图2所示,网格电极板4的四个角处的网孔41分别标记为A、B、C、D,横向AB网孔之间的网孔分别标记为AB1、 AB2、AB3、AB4、AB5,横向DC网孔之间的网孔分别标记为DC1、DC2、DC3、 DC4、DC5。竖向AD网孔之间的网孔分别标记为AD1、AD2、AD3、AD4、AD5,竖向BC网孔之间的网孔分别标记为BC1、BC2、BC3、BC4、BC5。相邻两网孔 41之间的距离为1.5cm。可知的,网格电极板4各边分的网孔数量越多,检测结果越准确。A
检测数据如下表1所示,单位为μs/cm。The test data are shown in Table 1 below, and the unit is μs/cm.
表1Table 1
对上述检测数据进行分析包括如下过程:The analysis of the above detection data includes the following processes:
(1)正常组织边界确定。正常组织点的电阻值与年龄、性别、体重等因素有关。不同年龄阶段、不同性别、不同体重的人群,其正常组织点的电阻值有所区别。即使同一人,不同部位的正常电阻值也可能不一致。(1) Determination of normal tissue boundaries. The resistance value of normal tissue points is related to factors such as age, gender and weight. Different age groups, different genders, and different weight groups have different resistance values of normal tissue points. Even for the same person, the normal resistance values of different parts may be inconsistent.
本实施例通过如下方式寻找正常组织点的电阻值:测得横向与纵向交点处的两个数据一致,即视为为正常电阻值,该部位的皮肤组织正常,无损伤。一般来说,按方形或长方形划线区域,最靠近四角的点的横向和纵向数据基本一致,视为该部位的皮肤组织正常,无损伤。In this embodiment, the resistance value of the normal tissue point is searched in the following way: if the two data at the intersection of the horizontal and vertical directions are consistent, it is regarded as a normal resistance value, and the skin tissue at this part is normal and has no damage. Generally speaking, the horizontal and vertical data of the points closest to the four corners are basically the same in the area drawn by a square or rectangle, and the skin tissue in this area is considered to be normal and without damage.
如表1中AB、AD、BC和DC网孔之间的电导率值基本都是2.15,即可认为是正常组织边界点。For example, the conductivity values between AB, AD, BC and DC meshes in Table 1 are basically 2.15, which can be considered as normal tissue boundary points.
(2)损伤组织点分析。如上表1可知:AB1与DC1网孔之间的电导率为 2.15,AD1与BC1网孔之间的电导率为2.15。因此,AB1-DC1线与AD1-BC1线的交点处的电导率记为2.15+2.15,即纵向检测数据与横向检测数据一致,该处为正常组织点。(2) Analysis of damaged tissue points. As can be seen from Table 1 above, the conductivity between the meshes of AB 1 and DC 1 is 2.15, and the conductivity between the meshes of AD 1 and BC 1 is 2.15. Therefore, the electrical conductivity at the intersection of the AB 1 -DC 1 line and the AD 1 -BC 1 line is recorded as 2.15+2.15, that is, the longitudinal detection data is consistent with the transverse detection data, and this place is a normal tissue point.
如上表1可知:AB1与DC1网孔之间的电导率为2.15,AD2与BC2网孔之间的电导率为2.82。因此,AB1-DC1线与AD2-BC2线的交点处的电导率记为 2.15+2.82,即纵向检测数据与横向检测数据不一致,并且其中有一个数据为阴性数据(也可以说是正常数据),则该处为边界组织点。As shown in Table 1 above, the conductivity between the meshes of AB 1 and DC 1 is 2.15, and the conductivity between the meshes of AD 2 and BC 2 is 2.82. Therefore, the electrical conductivity at the intersection of the AB 1 -DC 1 line and the AD 2 -BC 2 line is recorded as 2.15+2.82, that is, the longitudinal detection data is inconsistent with the transverse detection data, and one of the data is negative data (it can also be said to be normal data), then this is the boundary tissue point.
如上表1可知:AB3与DC3网孔之间的电导率为3.55,AD3与BC3网孔之间的电导率为3.45。因此,AB3-DC3线与AD3-BC3线的交点处的电导率记为 3.55+3.45,即纵向和横向检测数据没有阴性数据(也可以说是没有正常数据),则该处为损伤组织点。As can be seen in Table 1 above, the conductivity between the meshes of AB 3 and DC 3 is 3.55, and the conductivity between the meshes of AD 3 and BC 3 is 3.45. Therefore, the electrical conductivity at the intersection of the AB 3 -DC 3 line and the AD 3 -BC 3 line is recorded as 3.55+3.45, that is, there is no negative data in the longitudinal and transverse test data (it can also be said that there is no normal data), then the place is Damage tissue point.
(3)损伤程度判断。(3) Judgment of the degree of damage.
方法一:根据交点处纵向检测数据与横向检测数据之和的大小判断。具体的,检测数据的值越大,此处损伤程度越大,反之则小。如表1中AB3-DC3线与AD3-BC3线的交点处的电导率为3.55+3.45=7,此处的值最大,表明此点处组织损伤程度最大。Method 1: Judging according to the size of the sum of the vertical detection data and the horizontal detection data at the intersection. Specifically, the greater the value of the detection data, the greater the damage degree here, and vice versa. As shown in Table 1, the electrical conductivity at the intersection of the AB 3 -DC 3 line and the AD 3 -BC 3 line is 3.55+3.45=7, and the value here is the largest, indicating that the degree of tissue damage is the greatest at this point.
方法二:根据损伤度进行判断。具体的,如表1中正常点的纵向检测数据与横向检测数据为2.15+2.15,AB3-DC3线与AD3-BC3线的交点处的电导率为 3.55+3.45=7。损伤度=正常点/损伤点=(2.15+2.15)/(3.55+3.45)=0.614度。损伤度在0~1之间变化,为1表示无损伤,小于1表示有损伤,越接近1表示损伤程度越小,越接近0表示损伤程度越大。Method 2: Judging according to the degree of damage. Specifically, as shown in Table 1, the longitudinal detection data and transverse detection data of the normal point are 2.15+2.15, and the electrical conductivity at the intersection of the AB 3 -DC 3 line and the AD 3 -BC 3 line is 3.55+3.45=7. Damage degree=normal point/damage point=(2.15+2.15)/(3.55+3.45)=0.614 degree. The degree of damage varies between 0 and 1, where 1 means no damage, less than 1 means there is damage, the closer to 1, the smaller the degree of damage, and the closer to 0, the greater the degree of damage.
根据损伤度进行判断,可以应用在不同个体之间,相同部位或不同部位之间进行损伤程度的比较。Judging according to the degree of damage can be used to compare the degree of damage between different individuals, the same part or between different parts.
以上所述,仅为本发明的具体实施方式,但本发明的保护范围并不局限于此,任何熟悉本技术领域的技术人员在本发明揭露的技术范围内,可轻易想到变化或替换,都应涵盖在本发明的保护范围之内。因此,本发明的保护范围应以所述权利要求的保护范围为准。The above are only specific embodiments of the present invention, but the protection scope of the present invention is not limited to this. Any person skilled in the art can easily think of changes or substitutions within the technical scope disclosed by the present invention. should be included within the protection scope of the present invention. Therefore, the protection scope of the present invention should be based on the protection scope of the claims.
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010647729.3A CN111938639A (en) | 2020-07-07 | 2020-07-07 | Device for detecting injury degree and range of organism soft tissue based on electrical impedance method |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010647729.3A CN111938639A (en) | 2020-07-07 | 2020-07-07 | Device for detecting injury degree and range of organism soft tissue based on electrical impedance method |
Publications (1)
Publication Number | Publication Date |
---|---|
CN111938639A true CN111938639A (en) | 2020-11-17 |
Family
ID=73340264
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202010647729.3A Pending CN111938639A (en) | 2020-07-07 | 2020-07-07 | Device for detecting injury degree and range of organism soft tissue based on electrical impedance method |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN111938639A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115153492A (en) * | 2022-07-20 | 2022-10-11 | 梅拉宠物护理股份有限公司 | Modularized intelligent body fat scale with pet body shape detection function |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1558111A (en) * | 1977-08-19 | 1979-12-19 | Radelkis Electrokemiai | Method and sensor device for detecting the location and orcharacter of a lesion in body tissure |
WO1991011957A1 (en) * | 1990-02-14 | 1991-08-22 | Georgetown University | Evaluating tissue changes resulting from therapeutic hyperthermia |
US20060052678A1 (en) * | 2004-09-02 | 2006-03-09 | Drinan Darrel D | Monitoring platform for wound and ulcer monitoring and detection |
US20080103550A1 (en) * | 2006-10-30 | 2008-05-01 | Stuart Wenzel | Multiple electrode wound healing patch |
EP2127694A1 (en) * | 2008-05-26 | 2009-12-02 | Koninklijke Philips Electronics N.V. | Multi-electrode path for monitoring and electrical stimulation of wound healing |
WO2010030225A1 (en) * | 2008-09-09 | 2010-03-18 | Fernando Seoane Martinez | Method and apparatus for brain damage detection |
CN103272328A (en) * | 2013-04-28 | 2013-09-04 | 苏州市职业大学 | XP embedded physiotherapy instrument system based on bioelectrical impedance mechanism |
US20160183837A1 (en) * | 2013-04-22 | 2016-06-30 | Timothy En-Pu Hui | Detection of tissue injury using microcurrent. Device name - Zone Finder |
CN109688900A (en) * | 2016-03-21 | 2019-04-26 | 奥赛斯克斯科技有限公司 | For positioning, measuring, monitor and treating the device and method of the inflammation of skin soft tissue and fascia layer |
CN109793516A (en) * | 2019-01-21 | 2019-05-24 | 浙江大学 | A kind of skin electrical impedance flexible detection device and skin electrical impedance detection method |
CN209032353U (en) * | 2018-07-30 | 2019-06-28 | 四川大学华西医院 | Wireless electrocardiogram monitoring lead device |
-
2020
- 2020-07-07 CN CN202010647729.3A patent/CN111938639A/en active Pending
Patent Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1558111A (en) * | 1977-08-19 | 1979-12-19 | Radelkis Electrokemiai | Method and sensor device for detecting the location and orcharacter of a lesion in body tissure |
WO1991011957A1 (en) * | 1990-02-14 | 1991-08-22 | Georgetown University | Evaluating tissue changes resulting from therapeutic hyperthermia |
US20060052678A1 (en) * | 2004-09-02 | 2006-03-09 | Drinan Darrel D | Monitoring platform for wound and ulcer monitoring and detection |
US20080103550A1 (en) * | 2006-10-30 | 2008-05-01 | Stuart Wenzel | Multiple electrode wound healing patch |
EP2127694A1 (en) * | 2008-05-26 | 2009-12-02 | Koninklijke Philips Electronics N.V. | Multi-electrode path for monitoring and electrical stimulation of wound healing |
WO2010030225A1 (en) * | 2008-09-09 | 2010-03-18 | Fernando Seoane Martinez | Method and apparatus for brain damage detection |
US20160183837A1 (en) * | 2013-04-22 | 2016-06-30 | Timothy En-Pu Hui | Detection of tissue injury using microcurrent. Device name - Zone Finder |
CN103272328A (en) * | 2013-04-28 | 2013-09-04 | 苏州市职业大学 | XP embedded physiotherapy instrument system based on bioelectrical impedance mechanism |
CN109688900A (en) * | 2016-03-21 | 2019-04-26 | 奥赛斯克斯科技有限公司 | For positioning, measuring, monitor and treating the device and method of the inflammation of skin soft tissue and fascia layer |
US20190175097A1 (en) * | 2016-03-21 | 2019-06-13 | Assessx Technology Ltd. | An apparatus and method to locate, measure, monitor, and treat inflammation of the skin's soft tissue and fascia layers |
CN209032353U (en) * | 2018-07-30 | 2019-06-28 | 四川大学华西医院 | Wireless electrocardiogram monitoring lead device |
CN109793516A (en) * | 2019-01-21 | 2019-05-24 | 浙江大学 | A kind of skin electrical impedance flexible detection device and skin electrical impedance detection method |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115153492A (en) * | 2022-07-20 | 2022-10-11 | 梅拉宠物护理股份有限公司 | Modularized intelligent body fat scale with pet body shape detection function |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP2175776B1 (en) | Impedance measurement process | |
AU2012351988B2 (en) | Devices, systems and methods for determining the relative spatial change in subsurface resistivities across frequencies in tissue | |
Ridner et al. | Comparison of upper limb volume measurement techniques and arm symptoms between healthy volunteers and individuals with known lymphedema | |
AU2014284372B2 (en) | Apparatuses for home use in determining tissue wetness | |
CN100393276C (en) | Body Fat Measuring Device | |
JPH0951885A (en) | Improved apparatus for acquisition of body impedance data using partial impedance and multiple frequency impedances | |
US20160331266A1 (en) | Biological impedance measurement probe, measurement system and method based on spectral characteristic | |
CN105930665B (en) | A kind of liver fat method for quantitative measuring based on ultrasonic attenuation coefficient | |
CN101940469A (en) | Method and portable device for detecting urine volume of bladder | |
EP3624685A1 (en) | Needle impedance electromyography and electrical impedance imaging for enhanced muscle diagnostics | |
JP2011505169A (en) | Hepatic steatosis diagnosis and monitoring device based on electrical impedance measurement | |
CN111938639A (en) | Device for detecting injury degree and range of organism soft tissue based on electrical impedance method | |
Liao et al. | Impedance sensing device for monitoring ulcer healing in human patients | |
CN105249979B (en) | A kind of noninvasive multiple spot guarding measuring device | |
JP2019523428A (en) | Electrical impedance measurement and EIT image for localization of subcutaneous micro-biological channel | |
Kang et al. | Development of an electrical impedance tomography spectroscopy for pressure ulcer monitoring tool: preliminary study | |
CN110811650B (en) | Urination prediction method and device | |
Parramon et al. | In vivo detection of liver steatosis in rats based on impedance spectroscopy | |
Dylke et al. | Bioimpedance for the spot measurement of tissue density | |
CN220876758U (en) | Bioimpedance measuring device | |
CN201920722U (en) | Subsection impedance multiple-frequency measuring device for human body | |
TWI441621B (en) | Device for detecting the time of micturating by using the bioimpedance technique and the method thereof | |
Gyorfi et al. | Proof of Concept Clinical Trial of Bioimpedance-based NAFLD Diagnosis Technique | |
Abie et al. | Efect of body orientation and joint movement on local bioimpedance measurements. | |
RU2247532C1 (en) | Method for predicting liquid congestion in hepatic sinusoids |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20201117 |
|
RJ01 | Rejection of invention patent application after publication |