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CN111936858A - 一种胃癌极早期细胞标志和胃癌前病变早期细胞标志及其在诊断试剂盒中的应用 - Google Patents

一种胃癌极早期细胞标志和胃癌前病变早期细胞标志及其在诊断试剂盒中的应用 Download PDF

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CN111936858A
CN111936858A CN202080001970.7A CN202080001970A CN111936858A CN 111936858 A CN111936858 A CN 111936858A CN 202080001970 A CN202080001970 A CN 202080001970A CN 111936858 A CN111936858 A CN 111936858A
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CN111936858B (zh
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李梢
张鹏
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Tsinghua University
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    • G01N33/57446—Specifically defined cancers of stomach or intestine
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    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
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Abstract

本发明人发现了一群在胃低级别异型增生阶段开始出现、具有特定分子特征、且具有高度癌变风险的细胞群(命名为“胃癌极早期细胞”)，可作为极早期诊断胃癌的标志。胃癌极早期细胞的分子标志被应用到制备基于胃组织或血液样本实现胃癌或其他消化系统肿瘤早期诊断的试剂盒中。该胃癌极早期细胞标志还可区分胃癌术后复发风险，以及肠、胰腺以及食管等消化系统器官肿瘤发生的风险。另外，本发明人还发现一群在胃癌前病变早期出现、具有特定分子特征的细胞群，可作为早期诊断胃癌前病变的标志，也被集成到试剂盒中。本发明可用于临床上早期诊断胃癌及其他消化道肿瘤的发生，也可作为上述消化道肿瘤防治的干预靶点，应用前景良好。

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PCT国内申请，说明书已公开。

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  1. PCT国内申请，权利要求书已公开。
CN202080001970.7A 2019-04-04 2020-04-05 一种胃癌极早期细胞标志和胃癌前病变早期细胞标志及其在诊断试剂盒中的应用 Active CN111936858B (zh)

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CN111781356A (zh) * 2019-04-04 2020-10-16 清华大学 一种胃癌极早期细胞标志和胃癌前病变早期细胞标志及其在诊断试剂盒中的应用

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Cited By (2)

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Publication number Priority date Publication date Assignee Title
CN113970638A (zh) * 2021-10-24 2022-01-25 清华大学 确定胃癌极早期发生风险及评估胃癌前病变进展风险的分子标志及其在诊断试剂盒中的应用
CN113970638B (zh) * 2021-10-24 2023-02-03 清华大学 确定胃癌极早期发生风险及评估胃癌前病变进展风险的分子标志及其在诊断试剂盒中的应用

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