CN111920894A - A kind of preparation method of Sanjin microcapsule preparation - Google Patents

Abstract

The invention discloses a preparation method of a Sanjin micro-capsule preparation, which comprises the steps of putting cherokee rose root, chinaroot greenbrier rhizome, sheep starter, climbing fern vine and centella into an extraction tank according to the weight ratio of 10:5:5:3:3, adding water for decoction, filtering, combining filtrates, concentrating to obtain a Sanjin extract, and drying by a pulse airflow dryer to obtain Sanjin powder; adding tea saponin, rhamnolipid, konjac glucomannan, carrageenan and Arabic gum into water according to the mass ratio of 3-5:1-3:3-5:5-10:10-20, heating and stirring uniformly to obtain capsule wall material liquid; adding the trilobal powder and the plasticizer into the capsule wall material liquid, and adding the capsule wall material liquid into a homogenizer for homogenization treatment, wherein the mass ratio of the trilobal powder to the plasticizer is 2-3:1, so as to obtain an emulsion; and adding into a spray fluidized bed for drying and granulating to obtain the Sanjin microcapsule granules. The Sanjin microcapsule preparation provided by the method can effectively realize high-efficiency encapsulation of the medicine, improve the stability of the medicine, prolong the storage period, and cover the bad smell of the Sanjin medicine, so that a patient can accept the Sanjin medicine more easily.

Description

A kind of preparation method of Sanjin microcapsule preparation

technical field

The invention relates to the technical field of Chinese patent medicine preparations, in particular to a preparation method of a Sanjin microcapsule preparation.

Background technique

Sanjin preparation is a traditional Chinese medicine preparation made from five kinds of traditional Chinese medicines, such as golden cherry root, golden thorn (Smilax), golden vine, sheep opening, centella asiatica, etc., and has been sold in the market. , Swelling, heat-clearing, diuretic, analgesic, antioxidant free radicals, improve immunity, etc. Functions and indications are: clearing away heat and detoxifying, removing dampness and dredging stranguria, and benefiting the kidney. It is used for damp-heat in the lower jiao, hot stranguria, short red urination, strangulation and astringent pain; acute and chronic pyelonephritis, cystitis, urinary tract infection are those with kidney deficiency and damp-heat syndrome.

Microencapsulation technology uses natural or synthetic polymer encapsulation materials (collectively referred to as capsule materials) as the capsule wall shell, and encapsulates solid drugs or liquid drugs (collectively referred to as core materials) in tiny, semi-permeable or sealed capsules. Thereby, the drug storehouse type microcapsules are formed, which are called microcapsules because their particle sizes are in the range of 1 to 250 μm and belong to the micron level. Microencapsulation technology enables the content to be released at a controlled rate under specific conditions, enabling controlled release or targeting of drugs. Because microencapsulation can improve the color, appearance, apparent density, solubility and other physical properties of the encapsulated substance; improve the stability of the core substance, improve the reactivity, durability, heat sensitivity and photosensitivity of the encapsulated substance, in the hospital field The corresponding application has been obtained.

At present, the commercially available Sanjin preparations are basically ordinary sugar-coated tablets or film-coated tablets. According to market sales, patient feedback and the inspection of finished product samples, the tablets are easily affected by moisture and deteriorate during storage, thus affecting the efficacy of the drug. , also directly affects the effect of treatment. And Sanjin Tablet has a strong taste of traditional Chinese medicine, which is unacceptable to some consumers.

The disclosure of the above background technology content is only used to assist the understanding of the inventive concept and technical solution of the present invention, and it does not necessarily belong to the prior art of this patent application. If there is no clear evidence that the above content has been disclosed on the filing date of this patent application The above background art should not be used to evaluate the novelty and inventive step of the present application.

SUMMARY OF THE INVENTION

Aiming at the deficiencies of existing Sanjin ordinary tablets, the invention provides a preparation method of Sanjin microcapsule preparation. The Sanjin microcapsule preparation provided by the method of the invention can not only effectively realize the high-efficiency encapsulation of the medicine, improve its stability, prolong the storage period, but also cover the bad smell of the Sanjin medicine, making it easier for patients to accept.

In order to achieve the above purpose, the technical scheme adopted in the present invention is as follows:

A preparation method of three gold microcapsule preparations, comprising the steps:

(1) Put golden cherry root, sarsaparilla, sheep opening, golden vine and centella asiatica in an extraction tank according to the weight ratio of 10:5:5:3:3, add water to decoct, filter, combine the filtrate, concentrate, and obtain Sanjin extract is dried by pulse air dryer to obtain Sanjin powder;

(2) Add tea saponin, rhamnolipid, konjac gum, carrageenan and gum arabic into water according to the mass ratio of 3-5:1-3:3-5:5-10:10-20, heat and stir evenly , get the capsule material liquid;

(3) adding the three gold powder, the plasticizer and the capsule material liquid into a homogenizer for homogenization treatment, the mass ratio of the three gold powder and the capsule material liquid is 1:2-3 to obtain an emulsion;

(4) adding the emulsion to a spray fluidized bed for drying and granulation to obtain Sanjin microcapsule particles.

Further, the decocting is to add 5-8 times water of the medicinal materials and traditional Chinese medicines, decocting for 1.5-2.5 hours each time, and decocting 2-3 times.

Further, the concentration is to concentrate to a solid content of 50-60% at a pressure of -0.05 to -0.10Mpa and a temperature of 60-80°C.

Further, the temperature of the pulsed gas drying is 800-100°C, and the wind speed is 10-15m/s.

Further, the mass fraction of the capsule material liquid is 25-35%.

Further, the plasticizer is composed of sucrose glycerol fatty acid ester, lauric acid monoglyceride and lecithin; its addition amount is 2-4% of the mass of Sanjin powder.

Further, the mass ratio of sucrose glycerol fatty acid ester, lauric acid monoglyceride and lecithin in the plasticizer is 1-3:1-3:3-5.

Further, the homogenization treatment is carried out under a pressure of 40-60MPa for 20-30min.

Further, in step (4), drying is carried out under the temperature of the spray inlet air being 40-60°C and the blast temperature of the fluidized bed being 60-80°C.

Compared with the prior art, the advantages and beneficial effects of the present invention are:

1. The Sanjin microcapsule preparation provided by the method of the present invention can not only effectively realize the efficient encapsulation of the medicine, the surface of the medicine is dense and smooth without pores, improve its stability, prolong the storage period, and can also cover the bad smell of the Sanjin medicine, make it easier for patients to accept.

2. This method uses tea saponin, rhamnolipid, konjac gum, carrageenan and gum arabic as the wall material, which not only improves the compactness of the microcapsules, but also makes it easier to encapsulate the three gold medicines, and the properties of the microcapsule products are more stable And cover up the bad smell of medicines.

3. The method uses a pulse air dryer to dry the Sanjin dry paste powder, which is heated evenly, and the drying efficiency is improved, which is beneficial to the dispersion of the Sanjin powder in the drying process.

4. The method of the present invention also adds a plasticizer composed of sucrose glycerol fatty acid ester, lauric acid monoglyceride and lecithin to improve the fluidity during the homogenization process, so that the three gold powder can be better combined with the wall material, and the The encapsulation effect of the wall material on the three gold powders makes the surface of the prepared microcapsules more dense and smooth, without pores, and the stability of the medicine is improved.

Detailed ways

The present invention will be further described in detail below in conjunction with specific embodiments. It should be emphasized that the following description is exemplary only, and is not intended to limit the scope of the invention and its application.

Example 1

A preparation method of three gold microcapsule preparations, comprising the steps:

(1) Put golden cherry root, sarsaparilla, sheep opening, golden vine and centella asiatica in the extraction tank according to the weight ratio of 10:5:5:3:3, add 6 times the weight of the medicinal materials and decoct 3 times, Decoct for 2h each time, filter, combine the filtrate, concentrate to 55% solid content at a pressure of -0.06Mpa and a temperature of 75°C to obtain Sanjin extract, which is then passed through a pulse air dryer at a temperature of 80°C and a wind speed of 80°C. Dry at 15m/s to obtain three gold powders;

(2) Add tea saponin, rhamnolipid, konjac gum, carrageenan and gum arabic into water according to the mass ratio of 4:3:5:8:12 to form a solution with a mass fraction of 32%, heat and stir evenly , get the capsule material liquid;

(3) Add the three gold powder, plasticizer and capsule material liquid into the homogenizer, and carry out homogenization treatment under the pressure of 50MPa for 30 minutes. The mass ratio of the three gold powder and the capsule material liquid is 1:2. The plasticizer is composed of sucrose glycerol fatty acid ester, lauric acid monoglyceride and lecithin in a mass ratio of 2:3:5; its addition amount is 3.6% of the mass of Sanjin powder to obtain an emulsion;

(4) The emulsion is added to the spray fluidized bed for drying and granulation. The drying is carried out at a spray air inlet temperature of 50°C and a fluidized bed blast temperature of 70°C to obtain a particle size of 80 meshes. Sanjin microcapsule particles.

Example 2

A preparation method of three gold microcapsule preparations, comprising the steps:

(1) Put golden cherry root, sarsaparilla, sheep opening, golden vine and centella asiatica in the extraction tank according to the weight ratio of 10:5:5:3:3, add 7 times the weight of medicinal materials and decoct for 2 times, Decoct for 2.5h each time, filter, combine the filtrate, concentrate to 50% solid content at a pressure of -0.08Mpa and a temperature of 65°C to obtain Sanjin extract, which is then passed through a pulse air dryer at a temperature of 100°C, Dry at a wind speed of 15m/s to obtain three gold powders;

(2) Add tea saponin, rhamnolipid, konjac gum, carrageenan and gum arabic into water according to the mass ratio of 3:2:4:7:15 to form a solution with a mass fraction of 28%, heat and stir evenly , get the capsule material liquid;

(3) Add the three gold powder, plasticizer and capsule material liquid into the homogenizer, and carry out homogenization treatment under the pressure of 60MPa for 25 minutes. The mass ratio of the three gold powder and the capsule material liquid is 1:2.5. The plasticizer is composed of 1:2:4 mass ratio of sucrose glycerol fatty acid ester, lauric acid monoglyceride and lecithin; its addition amount is 2.8% of the mass of Sanjin powder to obtain an emulsion;

(4) The emulsion is added to the spray fluidized bed for drying and granulation. The drying is carried out at a spray air inlet temperature of 60°C and a fluidized bed blast temperature of 80°C to obtain a particle size of 60 meshes. Sanjin microcapsule particles.

Example 3

A preparation method of three gold microcapsule preparations, comprising the steps:

(1) Put golden cherry root, sarsaparilla, sheep opening, golden vine and centella asiatica in the extraction tank according to the weight ratio of 10:5:5:3:3, add 5 times the weight of medicinal materials and decoct 3 times, Decoct for 2h each time, filter, combine the filtrate, concentrate to 50% solid content at a pressure of -0.08Mpa and a temperature of 70°C to obtain Sanjin extract, which is then passed through a pulse air dryer at a temperature of 90°C and a wind speed of 90°C. Dry at 12m/s to obtain three gold powders;

(2) Add tea saponin, rhamnolipid, konjac gum, carrageenan and gum arabic into water in a mass ratio of 5:2:3:8:12 to form a solution with a mass fraction of 28%, heat and stir evenly , get the capsule material liquid;

(3) Add the three gold powder, plasticizer and capsule material liquid into the homogenizer, and carry out homogenization treatment under the pressure of 50MPa for 25 minutes. The mass ratio of the three gold powder and the capsule material liquid is 1:3. The plasticizer is composed of 3:2:5 mass ratio of sucrose glycerol fatty acid ester, lauric acid monoglyceride and lecithin; its addition amount is 3.0% of the mass of Sanjin powder to obtain an emulsion;

(4) The emulsion is added to the spray fluidized bed for drying and granulation. The drying is carried out at a spray air inlet temperature of 60°C and a fluidized bed blast temperature of 70°C to obtain a particle size of 100 mesh. Sanjin microcapsule particles.

Example 4

A preparation method of three gold microcapsule preparations, comprising the steps:

(1) Put golden cherry root, sarsaparilla, sheep opening, golden vine and centella asiatica in the extraction tank according to the weight ratio of 10:5:5:3:3, add 7 times the weight of medicinal materials and decoct 3 times, Decoct for 2 hours each time, filter, combine the filtrate, concentrate to 50% solid content at a pressure of -0.10Mpa and a temperature of 60°C to obtain Sanjin extract, which is then passed through a pulse air dryer at a temperature of 100°C and a wind speed of 100°C. Dry at 10m/s to obtain three gold powders;

(2) Add tea saponin, rhamnolipid, konjac gum, carrageenan and gum arabic into water according to the mass ratio of 4:2:4:6:18 to form a solution with a mass fraction of 28%, heat and stir evenly , get the capsule material liquid;

(3) Add the three gold powder, plasticizer and capsule material liquid into the homogenizer, and carry out homogenization treatment under the pressure of 60MPa for 20 minutes. The mass ratio of the three gold powder and the capsule material liquid is 1:3. The plasticizer is composed of 3:2:4 sucrose glycerol fatty acid ester, lauric acid monoglyceride and lecithin in mass ratio; its addition amount is 2.7% of the mass of Sanjin powder to obtain an emulsion;

(4) The emulsion is added to the spray fluidized bed for drying and granulation. The drying is carried out at a spray air inlet temperature of 40°C and a fluidized bed blast temperature of 60°C to obtain a particle size of 80 meshes. Sanjin microcapsule particles.

Example 5

A preparation method of three gold microcapsule preparations, comprising the steps:

(1) Put golden cherry root, sarsaparilla, sheep opening, golden vine and centella asiatica in the extraction tank according to the weight ratio of 10:5:5:3:3, add 8 times the weight of the medicinal materials and decoct for 2 times, Decoct for 2.5 hours each time, filter, combine the filtrate, concentrate to 60% solid content at a pressure of -0.08Mpa and a temperature of 65°C to obtain Sanjin extract, which is then passed through a pulse air dryer at a temperature of 100°C, Dry at a wind speed of 12m/s to obtain three gold powders;

(2) Add tea saponin, rhamnolipid, konjac gum, carrageenan and gum arabic into water according to the mass ratio of 5:2:3:7:13 to form a solution with a mass fraction of 30%, heat and stir evenly , get the capsule material liquid;

(3) Add the three gold powder, plasticizer and capsule material liquid into the homogenizer, and carry out homogenization treatment under the pressure of 40MPa for 25 minutes. The mass ratio of the three gold powder and the capsule material liquid is 1:3. The plasticizer is composed of 3:3:4 mass ratio of sucrose glycerol fatty acid ester, lauric acid monoglyceride and lecithin; its addition amount is 3.5% of the mass of Sanjin powder to obtain an emulsion;

(4) The emulsion is added to the spray fluidized bed for drying and granulation. The drying is carried out at a spray air inlet temperature of 40°C and a fluidized bed blast temperature of 80°C to obtain a particle size of 60 meshes. Sanjin microcapsule particles.

The encapsulation efficiency and stability of Sanjin microcapsule particles were measured according to conventional methods in Examples 1-5, wherein the encapsulation efficiency=mass of asiaticoside encapsulated in the microcapsule/encapsulated and unencapsulated in the microcapsule The total amount of asiaticoside × 100%, the calculation conditions for the retention rate of the product content are: 25 ℃, RH75% sampling measurement, the measurement results are shown in Table 1.

Table 1: Encapsulation efficiency and stability measurement results of three gold microcapsule preparation products of the present invention

It can be known from the above test results that the three gold microcapsule preparation prepared by the present invention has good encapsulation efficiency and product stability.

The above content is a further detailed description of the present invention in conjunction with specific/preferred embodiments, and it cannot be considered that the specific implementation of the present invention is limited to these descriptions. For those skilled in the art to which the present invention pertains, without departing from the concept of the present invention, they can also make several substitutions or modifications to the described embodiments, and these substitutions or modifications should be regarded as It belongs to the protection scope of the present invention.

Claims (9)

1. A preparation method of a three-gold microcapsule preparation is characterized by comprising the following steps: the method comprises the following steps:

(1) placing cherokee rose root, chinaroot greenbrier, Yangkou, sargentgloryvine stem and centella asiatica in an extraction tank according to the weight ratio of 10:5:5:3:3, adding water for decoction, filtering, combining filtrates, concentrating to obtain Sanjin extract, and drying by a pulse airflow dryer to obtain Sanjin powder;

(2) adding tea saponin, rhamnolipid, konjac glucomannan, carrageenan and Arabic gum into water according to the mass ratio of 3-5:1-3:3-5:5-10:10-20, heating and stirring uniformly to obtain capsule wall material liquid;

(3) adding the Trigold powder, the plasticizer and the capsule wall material liquid into a homogenizer for homogenization treatment, wherein the mass ratio of the Trigold powder to the capsule wall material liquid is 1:2-3, and obtaining an emulsion;

(4) and adding the emulsion into a spray fluidized bed for drying and granulating to obtain the gold microcapsule particles.

2. The method for preparing a trilobal microcapsule formulation according to claim 1, wherein: the decoction is carried out by adding 5-8 times of water into the raw materials, and decocting for 1.5-2.5h and 2-3 times each time.

3. The method for preparing a trilobal microcapsule formulation according to claim 1, wherein: the concentration is carried out under the pressure of-0.05 to-0.10 Mpa and the temperature of 60 to 80 ℃ until the solid content is 50 to 60 percent.

4. The method for preparing a trilobal microcapsule formulation according to claim 1, wherein: the drying temperature of the pulse gas is 80-100 ℃, and the wind speed is 10-15 m/s.

5. The method for preparing a trilobal microcapsule formulation according to claim 1, wherein: the mass fraction of the capsule wall material liquid is 25-35%.

6. The method for preparing a trilobal microcapsule formulation according to claim 1, wherein: the plasticizer consists of sucrose glycerin fatty acid ester, lauric acid monoglyceride and lecithin; the addition amount is 2-4% of the weight of the three-gold powder.

7. The method for preparing a trilobal microcapsule formulation according to claim 6, wherein: the mass ratio of the sucrose glycerin fatty acid ester to the lauric acid monoglyceride to the lecithin in the plasticizer is 1-3:1-3: 3-5.

8. The method for preparing a trilobal microcapsule formulation according to claim 1, wherein: the homogenizing treatment is carried out under 40-60MPa for 20-30 min.

9. The method for preparing a trilobal microcapsule formulation according to claim 1, wherein: and (4) drying at the air inlet spraying temperature of 40-60 ℃ and the air blowing temperature of the fluidized bed of 60-80 ℃.