CN111919982A - Natural plant beverage for relieving alcoholism and preparation method thereof - Google Patents
Natural plant beverage for relieving alcoholism and preparation method thereof Download PDFInfo
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- CN111919982A CN111919982A CN202010835550.0A CN202010835550A CN111919982A CN 111919982 A CN111919982 A CN 111919982A CN 202010835550 A CN202010835550 A CN 202010835550A CN 111919982 A CN111919982 A CN 111919982A
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- hangover
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Abstract
本发明公开了一种天然植物解酒饮料及其制备方法,包括以下步骤:按配比选取葛根、枸杞、金银花、菊花、山楂和金线莲;对选取的原料中加入纯净水,并加热熬煮过滤;对一次提取后的原料再次加纯净水进行二次加热提取,到二次提取滤液;将一次提取滤液和二次提取滤液进行混合,得到混合液冷却后备用将冷却后的混合液加热定溶,得到定溶液备用;对定溶液进行再次过滤,得到初级产品;将初级产品灌装,灌装后进行高温灭菌,高温灭菌灌装后,打码,检验,包装即得所述天然植物解酒饮料。本发明的天然植物解救饮料味甘而香,可用于日常饮用,也可用于宴会酒席,具有提高免疫功能、增进健康、保护肝脏、解酒、养胃等功效。The invention discloses a natural plant hangover drink and a preparation method thereof, comprising the following steps: selecting pueraria, wolfberry, honeysuckle, chrysanthemum, hawthorn and clematis according to the proportion; adding pure water to the selected raw materials, and heating and boiling Filtration; adding pure water to the raw material after the primary extraction for secondary heating extraction to obtain the secondary extraction filtrate; mixing the primary extraction filtrate and the secondary extraction filtrate to obtain the mixed solution and cooling it for later use. Dissolve to obtain a fixed solution for use; filter the fixed solution again to obtain a primary product; fill the primary product, carry out high temperature sterilization after filling, after high temperature sterilization and filling, coding, inspection, and packaging to obtain the natural Plant hangover drink. The natural plant rescue beverage of the invention has a sweet and fragrant taste, can be used for daily drinking, and can also be used for banquets, and has the effects of improving immune function, improving health, protecting liver, relieving alcohol, nourishing stomach and the like.
Description
技术领域technical field
本发明涉及解酒饮料技术领域,更具体的说是涉及天然植物解酒饮料及其制备方法。The invention relates to the technical field of hangover beverages, and more particularly to a natural plant hangover beverage and a preparation method thereof.
背景技术Background technique
医学研究证明,少量饮酒有利于健康,能加速血液循环,消除疲劳,促进睡眠。但过量饮酒则对人有巨大的危害,不仅对肝脏、消化道、胰腺、心脏、神经系统、生殖系统造成不同程度的损伤,还会增加肝癌、某些消化道癌、直肠癌、结肠癌、乳腺癌的发病率。其中对肝脏的损伤尤为巨大,有报道称酒精性肝硬化占各种肝硬化病因的54-84%。此外饮酒过量还会使人产生恶心、呕吐、头晕、咽干等诸多不适。Medical research has proved that a small amount of alcohol is beneficial to health, can accelerate blood circulation, eliminate fatigue, and promote sleep. However, excessive drinking is very harmful to people. It not only causes different degrees of damage to the liver, digestive tract, pancreas, heart, nervous system, and reproductive system, but also increases liver cancer, some digestive tract cancers, rectal cancer, colon cancer, incidence of breast cancer. Among them, the damage to the liver is particularly huge, and it has been reported that alcoholic liver cirrhosis accounts for 54-84% of various causes of liver cirrhosis. In addition, excessive drinking can also cause nausea, vomiting, dizziness, dry throat and many other discomforts.
中国是一个有着悠久文化传统的国家,受传统习俗和文化的影响,饮酒是中国人一种普遍且不可避免的行为。据2002年全国营养与健康调查,我国15岁以上的居民中,男性饮酒比例是39.6%,女性饮酒比例则为4.5%。城乡居民饮酒的比例分别为20.9%和21.1%,农村饮酒比例略高于城市。随着时代的发展,人们越来越关注饮酒的同时又能保障身体的健康。China is a country with a long cultural tradition. Influenced by traditional customs and culture, drinking is a common and inevitable behavior of Chinese people. According to the National Nutrition and Health Survey in 2002, among residents over 15 years old, the proportion of men drinking alcohol is 39.6%, and the proportion of women drinking is 4.5%. The proportion of urban and rural residents who drink alcohol is 20.9% and 21.1% respectively, and the proportion of drinking in rural areas is slightly higher than that in urban areas. With the development of the times, people pay more and more attention to drinking alcohol while protecting their health.
我国有关解酒药的使用记载甚多,最初记载始见于《神农本草经》,如水萍条:“下水气胜酒,长须发”及腐婢条:“病酒,头痛”;唐朝《食疗本草》中有“葛根蒸之,消酒毒”;宋代《证类本草》则记载了30种能解酒的药物;明代的《本草纲目》收载解酒药有107种《中药大辞典》中有80多种有药具有治酒醉、解酒毒。There are many records about the use of hangover medicines in my country. The first records were found in the "Shen Nong's Materia Medica", such as Shuiping Tiao: "Shuiqi wins wine, long beard and hair" and Rotten Maid Tiao: "Sick wine, headache"; Tang Dynasty "Dietary Therapy" "Ben Cao" has "pueraria steamed to eliminate alcohol poisoning"; "Zhenglei Materia Medica" of the Song Dynasty recorded 30 kinds of drugs that can relieve hangover; "Compendium of Materia Medica" of the Ming Dynasty contained 107 kinds of hangover drugs "Dictionary of Traditional Chinese Medicine" There are more than 80 kinds of medicines that can cure drunkenness and detoxification.
市面有不少能够解酒的中成药,如葛根散、石膏汤、藿香正气散等。这些中成药有明显的治疗作用,且多为针对其它疾患所立的方,服后虽能对醉酒有所裨益,但其治疗作用对单纯饮酒的健康人来说可能就是副作用了。因而护肝解酒植物饮料必将是人们饮酒后健康保健或代替酒的必然选择。There are many Chinese patent medicines that can hangover in the market, such as Pueraria Root Powder, Gypsum Soup, Huoxiang Zhengqi Powder, etc. These Chinese patent medicines have obvious therapeutic effects, and most of them are prescriptions for other diseases. Although they can be beneficial to drunkenness after taking them, their therapeutic effects may be side effects for healthy people who simply drink. Therefore, herbal beverages that protect the liver and hangover will be the inevitable choice for people to take health care or to replace alcohol after drinking.
关于酒的性能,历代本草皆有记载。《内经》载:“其气悍以清”,“其气剽悍”,“酒气盛而剽悍”;《名医别录》谓:“味苦甘辛,大热有毒,气味俱阳”;《本草纲目谓:“烧酒,辛、甘,大热,有大毒”;《中药大辞典》谓:“甘苦辛,温酒在人体的运化《内经》中也有记载。《灵枢.经脉》谓:“饮酒者,卫气先行于皮肤,先充络脉,络脉先盛,故卫气以平,营气乃满,而经脉大盛”;《素问.厥论》曰:“酒入于胃,则络脉满而经脉虚。”《灵枢.论勇》载有:“酒者,水谷之精,熟谷之液也,其气剽悍,其入于胃中,则胃中,则胃胀,气上逆,满于胸中,肝浮胆横......”。综合酒在人体运化过程可以看出:饮酒入胃,胃为阳明之腑,喜润恶燥,而酒性剽悍,必然影响胃的腐熟、通降水谷的功能,故可见恶心呕吐、嗳气腹胀、纳呆等症状。中医解酒能针对酒毒以解决其病因,针对肝胃等脏腑不适以解决其危害,达到双重治疗效果。Regarding the properties of wine, the herbal medicines of all dynasties have been recorded. "The Classic of Internal Medicine" contains: "its qi is strong and clear", "its qi is fierce and fierce", and "the spirit of wine is strong and fierce"; "Famous Doctors" says: "The taste is bitter and sweet, the heat is poisonous, and the smell is both yang"; "Materia Medica" The outline says: "Shochu, pungent, sweet, hot, and poisonous"; "Dictionary of Traditional Chinese Medicine" says: "Sweet, bitter, and warm wine is also recorded in the "Nei Jing" of the human body's transportation and transformation. "Lingshu. Meridian" states that : "For those who drink alcohol, the Wei Qi first travels to the skin, fills the collaterals first, and the collaterals first flourish, so the Wei Qi is leveled, the Ying Qi is full, and the meridians are prosperous." In the stomach, the collaterals are full and the meridians are deficient. "Lingshu. On Yong" contains: "Wine is the essence of water and grain, and the liquid of cooked grain. Its qi is fierce and fierce. When it enters the stomach, it will be in the stomach, and then the stomach will be distended, and the qi will be reversed, and the chest will be full. , the liver floats and gallbladder...". Comprehensive wine in the process of human body transportation and transformation can be seen: drinking into the stomach, the stomach is the viscera of Yangming, like moisturizing and disgusting dryness, and the alcohol is aggressive, which will inevitably affect the decomposing of the stomach. , and the function of clearing the valley, so symptoms such as nausea and vomiting, belching, abdominal distension, and anorexia can be seen. Chinese medicine hangover can solve the cause of alcohol poisoning, and can solve the harm of liver and stomach and other viscera discomfort to achieve dual therapeutic effects.
发明内容SUMMARY OF THE INVENTION
本发明所要解决的技术问题便是针对上述现有技术的不足,提供一种天然植物解酒饮料及其制备方法,该天然植物解救饮料味甘而香,可用于日常饮用,也可用于宴会酒席,具有提高免疫功能、增进健康、保护肝脏、解酒、养胃等功效。The technical problem to be solved by the present invention is to aim at the deficiencies of the above-mentioned prior art, and to provide a natural plant hangover drink and a preparation method thereof. The natural plant hangover drink is sweet and fragrant, and can be used for daily drinking and banquets. It has the functions of improving immune function, improving health, protecting liver, relieving alcohol, nourishing stomach and so on.
为实现上述目的,本发明提供如下技术方案:To achieve the above object, the present invention provides the following technical solutions:
天然植物解酒饮料,其特征在于,包括按重量份计的以下原料:葛根5-25kg、枸杞1-3kg、金银花2-5kg、菊花0.5-2kg、山楂0.5-2kg和金线莲0.1-0.8kg、纯净水50-200kg。The natural plant hangover drink is characterized in that it includes the following raw materials by weight: 5-25kg of pueraria, 1-3kg of wolfberry, 2-5kg of honeysuckle, 0.5-2kg of chrysanthemum, 0.5-2kg of hawthorn and 0.1-0.8 of clematis kg, purified water 50-200kg.
优选的,在上述一种天然植物解酒饮料及其制备方法中,包括按重量份计的葛根10kg、枸杞2kg、金银花3kg、菊花1kg、山楂1kg和金线莲0.5kg、纯净水100kg。Preferably, in the above-mentioned natural plant hangover drink and its preparation method, it comprises by weight 10kg of pueraria, 2kg of wolfberry, 3kg of honeysuckle, 1kg of chrysanthemum, 1kg of hawthorn, 0.5kg of clematis, and 100kg of purified water.
优选的,在上述一种天然植物解酒饮料及其制备方法中,包括以下步骤:Preferably, in the above-mentioned natural plant hangover drink and its preparation method, the following steps are included:
(1)按配比选取葛根、枸杞、金银花、菊花、山楂和金线莲,将其清洗干净后放入容器中;(1) select kudzu root, wolfberry, honeysuckle, chrysanthemum, hawthorn and clematis according to the proportion, put them into the container after cleaning them;
(2)对选取的原料中加入纯净水,并加热至100℃进行提取熬煮,提取时间30min,加热提取后过滤,取得一次提取滤液备用;(2) adding purified water to the selected raw material, and heating to 100 ° C for extraction and cooking, extraction time 30min, heating and extraction after filtering, and obtaining an extraction filtrate for subsequent use;
(3)对一次提取后的原料再次加纯净水进行二次加热提取,加热至100℃后提取20min,提取后过滤,得到二次提取滤液;(3) adding purified water to the raw material after the primary extraction to perform secondary heating extraction, heating to 100° C. for extraction for 20 min, and filtering after extraction to obtain a secondary extraction filtrate;
(4)将一次提取滤液和二次提取滤液进行混合,并加入白砂糖和麦芽糖混合均匀,得到混合液冷却后备用;(4) the primary extraction filtrate and the secondary extraction filtrate are mixed, and white granulated sugar and maltose are added to mix, and the mixture is cooled for subsequent use;
(5)将冷却后的混合液加热定溶,得到定溶液备用;(5) heating the cooled mixed solution to obtain a fixed solution for subsequent use;
(6)对定溶液进行再次过滤,过滤至定溶液中的可溶性固型物的含量在6%-10%,得到初级产品;(6) filter the fixed solution again, filter until the content of soluble solids in the fixed solution is 6%-10%, to obtain primary product;
(7)将初级产品灌装,灌装后进行高温灭菌,高温灭菌灌装后,打码,检验,包装即得所述天然植物解酒饮料。(7) Filling the primary product, carrying out high temperature sterilization after filling, coding, testing and packaging after high temperature sterilization and filling to obtain the natural plant hangover drink.
优选的,在上述一种天然植物解酒饮料及其制备方法中,步骤(2)中加入50kg的纯净水进行加热提取。Preferably, in the above-mentioned natural plant hangover drink and its preparation method, in step (2), 50 kg of purified water is added for heating and extraction.
优选的,在上述一种天然植物解酒饮料及其制备方法中,步骤(3)中加入50kg的纯净水进行加热提取。Preferably, in the above-mentioned natural plant hangover drink and the preparation method thereof, 50 kg of purified water is added in step (3) for heating and extraction.
优选的,在上述一种天然植物解酒饮料及其制备方法中,步骤(2)和步骤(3)中过滤采用布袋式过滤机。Preferably, in the above-mentioned natural plant hangover drink and the preparation method thereof, a bag filter is used for filtering in steps (2) and (3).
优选的,在上述一种天然植物解酒饮料及其制备方法中,步骤(7)中的高温灭菌为在115℃-121℃的高温环境中灭菌30min-40min。Preferably, in the above-mentioned natural plant hangover drink and the preparation method thereof, the high temperature sterilization in step (7) is sterilization in a high temperature environment of 115°C-121°C for 30min-40min.
本发明所用原料的药理性能为:The pharmacological properties of the raw materials used in the present invention are:
葛根:豆科植物野葛的干燥根,习称野葛,是中国传统医学中最具代表性的解酒药物之一。甘、辛,凉。有解肌退热,透疹,生津止渴,升阳止泻之功。富含黄酮类、三萜皂苷类、生物碱类等。可有效从乙醇的吸收、代谢、排泄三个环节发挥解酒作。Pueraria lobata: The dried root of the legume kudzu, commonly known as kudzu, is one of the most representative hangover medicines in traditional Chinese medicine. Sweet, spicy, cool. It has the functions of relieving muscle and reducing fever, expelling rash, promoting body fluid and quenching thirst, raising yang and stopping diarrhea. Rich in flavonoids, triterpenoid saponins, alkaloids, etc. It can effectively play a hangover effect from the three links of ethanol absorption, metabolism and excretion.
山楂:又名山里果、山里红,蔷薇科山楂属山(CrataeguspinnatifidaBunge)的果实,富含黄酮类、三萜类、甾体类,有机酸等;具有降血脂、血压、强心、抗心律不齐等作用,同时也是健脾开胃、消食化滞、活血化痰的良药,对胸膈脾满、疝气、血淤、闭经等症有很好的疗效。Hawthorn: also known as Shanliguo, Shanlihong, the fruit of CrataeguspinnatifidaBunge in the Rosaceae family, rich in flavonoids, triterpenoids, steroids, organic acids, etc.; At the same time, it is also a good medicine for invigorating the spleen and appetizing, digesting food and resolving stagnation, promoting blood circulation and resolving phlegm.
金银花金银花(LonicetajaponicaThunb),别名:金银藤、双宝花、金童玉女花,忍冬科多年生半常绿缠绕性木质藤本植物忍冬的花蕾和初开的花,半常绿灌木。其是传统的中药材,其主要药物成份是木犀草素、肌醇及皂甙,鞣质等;味甘性寒,归肺、心、胃经。具有抗菌清热、解毒疮、止痢疾、去皮肤血热、养血止渴等作用,亦是人们钟情的草本茶饮之一。Honeysuckle honeysuckle (LonicetajaponicaThunb), alias: golden and silver rattan, double treasure flower, golden child jade flower, honeysuckle perennial semi-evergreen entwining woody vine buds and early blooming flowers of honeysuckle, semi-evergreen shrub. It is a traditional Chinese medicinal material, and its main medicinal ingredients are luteolin, inositol and saponins, tannins, etc.; it is sweet and cold in nature, and belongs to the lung, heart and stomach meridians. It has the functions of antibacterial and heat-clearing, detoxifying sore, relieving dysentery, removing skin and blood heat, nourishing blood and quenching thirst, etc. It is also one of the favorite herbal teas.
菊花(ChryDanthemummorifoliumRamat.),多年生菊科草本植物,其花瓣呈舌状或筒状。甘、苦,微寒。归肺、肝经。能疏散风热,平肝明目,清热解毒。《药鉴》载其“......解醉汉昏迷,易醒,共干葛(宜葛花——笔者注)煎汤。Chrysanthemum (ChryDanthemummorifoliumRamat.), a perennial Asteraceae herb, its petals are tongue-shaped or tubular. Sweet, bitter, slightly cold. Returns the lung and liver meridians. Can disperse wind-heat, calm liver and improve eyesight, clear heat and detoxify. "Pharmaceutical Illustrated" stated that "...to relieve the drunken coma, easy to wake up, and make a decoction of dry Ge (Yi Ge Hua - author's note).
金线莲[Anoectochilusroxburghii(Wall.)Lindl]是兰科兰属多年生草本植物,又名金线兰、金蚕、金不换等,因其叶脉呈金黄色而得名。主要分布于我国广东、广西、福建、江西、四川省;日本、斯里兰卡、印度、尼泊尔也有分布。民间有“药王”、“金草”之美誉,其味甘、微苦,性平、微寒,具有清热凉血、祛风利湿、强心、固肾、利尿、平肝、降血压、解毒、止痛、镇咳等功效,民间多用于治疗咯血、支气管炎、肾炎、膀胱炎、糖尿病、乳糜尿、血尿、风湿性关节炎、小儿急惊风、毒蛇咬伤等。近年来临床主要用于治疗高血压、糖尿病、心脏病、肺炎、急慢性肝炎、肾炎等病证;也可用于解酒叶,是具有一定医药作用和文化价值的草本植物。Clematis [Anoectochilusroxburghii (Wall.) Lindl] is a perennial herb of the genus Orchidaceae, also known as Golden Clematis, Golden Silkworm, Jinbuhuan, etc. It is named for its golden-yellow veins. Mainly distributed in my country's Guangdong, Guangxi, Fujian, Jiangxi, Sichuan Province; Japan, Sri Lanka, India, Nepal are also distributed. The folk have the reputation of "King of Medicine" and "Golden Grass". Its taste is sweet, slightly bitter, flat and slightly cold in nature. , detoxification, pain relief, antitussive and other effects, folks are mostly used for the treatment of hemoptysis, bronchitis, nephritis, cystitis, diabetes, chyluria, hematuria, rheumatoid arthritis, acute convulsions in children, snake bites, etc. In recent years, it is mainly used to treat hypertension, diabetes, heart disease, pneumonia, acute and chronic hepatitis, nephritis and other diseases.
枸杞中所含有的VA、VB、VC和VE都有较强的抗氧化能力,特别是水相中的VC和脂相中的VE,已成为相应的抗氧化作用的标准物质。在枸杞中含有的β-胡萝卜素和叶黄素、玉米黄素、隐黄质等,这些物质的抗氧化能力都很强,都具有消除单线态氧的作用,虽然消除能力各不相同,但都比VE的消除能力大数十倍,均能有效的灭杀自由基,而且对人体组织受氧化伤害有很好的防御作用和治疗恢复作用。枸杞中还含有丰富的黄酮类物质,而黄酮类质对生物膜中脂质过氧化有较强的抑制作用。枸杞中还含有大量不同种类的抗氧化因子,所以枸杞就具有很强的抗氧化能力,成为最典型的最有效的外源性抗氧化物质,也就表现出了延缓衰老、提高免疫力、抗疲劳、降血脂、抑血糖、强肾、保肝、明目、防肿瘤、抑制动脉硬化等一系列的功能。The VA, VB, VC and VE contained in wolfberry have strong antioxidant capacity, especially the VC in the water phase and the VE in the lipid phase, which have become the standard substances for the corresponding antioxidant effect. The β-carotene, lutein, zeaxanthin, cryptoxanthin, etc. contained in wolfberry have strong antioxidant capacity, and all have the effect of eliminating singlet oxygen. Both are dozens of times larger than VE in their ability to eliminate free radicals. They can effectively kill free radicals, and have a good defense and healing effect on human tissues from oxidative damage. Lycium barbarum is also rich in flavonoids, and flavonoids have a strong inhibitory effect on lipid peroxidation in biofilms. Lycium barbarum also contains a large number of different types of antioxidant factors, so wolfberry has a strong antioxidant capacity, becoming the most typical and most effective exogenous antioxidant substances, which also shows anti-aging, improving immunity, anti-aging Fatigue, lowering blood lipids, suppressing blood sugar, strengthening kidneys, protecting liver, improving eyesight, preventing tumors, inhibiting arteriosclerosis and a series of functions.
经由上述的技术方案可知,与现有技术相比,本发明具有以下优点:As can be seen from the above technical solutions, compared with the prior art, the present invention has the following advantages:
本发明原料为药食同补的中药和果实,安全无毒副作用,来源非常广泛,营养丰富,可以保肝、安神、清热解毒,容易被身体吸收,可以做成多种形式的产品;The raw materials of the present invention are traditional Chinese medicines and fruits that are both medicinal and food supplements, which are safe and have no toxic and side effects, have a wide range of sources, are rich in nutrients, can protect the liver, soothe the nerves, clear heat and detoxify, are easily absorbed by the body, and can be made into various forms of products;
本发明的植物饮料配方科学合理,所选原料为常用的药食两用药物或新资源食品,原料来源广泛易;The formula of the plant beverage of the invention is scientific and reasonable, the selected raw materials are commonly used dual-use medicines or new resource foods, and the sources of raw materials are wide and easy;
本植物饮料制备工艺稳定且简单易行,适用于大生产,产品稳定行好,利于控制产品质量;The preparation process of the plant beverage is stable and simple, suitable for large-scale production, and the product is stable and good, which is beneficial to control the quality of the product;
本发明将葛根、枸杞、金银花、菊花、山楂和金线莲组合在一起,并通过大量实验确定组分之间的配比,使组合物发挥了很好的协调作用,安全有效,具有显著的醒酒解酒、保护肝脏的作用。The invention combines pueraria, medlar, honeysuckle, chrysanthemum, hawthorn and clematis, and determines the proportions of the components through a large number of experiments, so that the composition has a good coordination effect, is safe and effective, and has significant effects. Sober up hangover, protect the liver.
具体实施方式Detailed ways
下面将结合本发明实施例,对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.
实施例1Example 1
本实施例提供的解酒植物饮料,通过以下方法制备:The hangover botanical beverage provided by the present embodiment is prepared by the following methods:
(1)选取葛根10kg、枸杞2kg、金银花3kg、菊花1kg、山楂1kg和金线莲0.5kg;(1) choose pueraria 10kg, medlar 2kg, honeysuckle 3kg, chrysanthemum 1kg, hawthorn 1kg and clematis 0.5kg;
(2)将选取葛根、枸杞、金银花、菊花、山楂和金线莲放入提取罐中,然后向提取罐中加入50kg的纯净水,将提取罐加热至100℃后进行恒温提取,加热提取时间为30min,30min后将提取液倒出并采用布袋式过滤机进行过滤,过滤后得到次提取滤液备用;(2) will select kudzu root, wolfberry, honeysuckle, chrysanthemum, hawthorn and clematis and put into extraction tank, then add 50kg of pure water to extraction tank, extract at constant temperature after heating extraction tank to 100°C, and heat extraction time For 30min, after 30min, the extraction solution was poured out and filtered with a bag filter, and the secondary extraction filtrate was obtained after filtration;
(3)将一次提取后的原料在提取罐中再次加入入50kg的纯净水,将提取罐加热至100℃后进行恒温提取,加热提取时间为20min,20min后将提取液倒(3) adding the purified water of 50kg to the raw material after one extraction in the extraction tank again, heating the extraction tank to 100 ° C and performing constant temperature extraction, the heating extraction time is 20min, and the extraction solution is poured after 20min.
(4)将一次提取滤液和二次提取滤液进行混合,并加入白砂糖180g和麦芽糖120g进行混合调味,混合后得到混合液;(4) primary extraction filtrate and secondary extraction filtrate are mixed, and 180g of white granulated sugar and 120g of maltose are added for mixing and seasoning, and the mixed solution is obtained after mixing;
(5)将混合液加热加纯净水稀释定溶,得到定溶液;(5) the mixed solution is heated and diluted with purified water to obtain a fixed solution;
(6)对定溶液进行过滤,过滤至定溶液中的可溶性固型物的含量在6%-10%得到初级产品;(6) filter the fixed solution, filter until the content of soluble solids in the fixed solution is 6%-10% to obtain the primary product;
(7)将初级产品灌装,灌装后在115℃-121℃的高温环境中灭菌40min,高温灭菌后即得所述天然植物解酒饮料。(7) Filling the primary product, sterilizing it in a high temperature environment of 115°C-121°C for 40 minutes after filling, and obtaining the natural plant hangover drink after high temperature sterilization.
实施例2Example 2
本实施例提供的解酒植物饮料,通过以下方法制备:The hangover botanical beverage provided by the present embodiment is prepared by the following methods:
(1)选取葛根10kg、枸杞2kg、金银花3kg、菊花1kg、山楂1kg和金线莲0.5kg;(1) choose pueraria 10kg, medlar 2kg, honeysuckle 3kg, chrysanthemum 1kg, hawthorn 1kg and clematis 0.5kg;
(2)将选取葛根、枸杞、金银花、菊花、山楂和金线莲放入提取罐中,然后向提取罐中加入60kg的纯净水,将提取罐加热至100℃后进行恒温提取,加热提取时间为30min,30min后将提取液倒出并采用布袋式过滤机进行过滤,过滤后得到一次提取滤液备用;(2) will select kudzu root, wolfberry, honeysuckle, chrysanthemum, hawthorn and clematis and put into extraction tank, then add 60kg of purified water to extraction tank, extract at constant temperature after heating extraction tank to 100°C, and heat extraction time For 30min, after 30min, the extraction solution was poured out and filtered with a bag filter, and an extraction filtrate was obtained after filtration for subsequent use;
(3)将一次提取后的原料在提取罐中再次加入80kg的纯净水,将提取罐加热至100℃后进行恒温提取,加热提取时间为20min,20min后将提取液倒出并采用布袋式过滤机进行过滤,过滤后得到二次提取滤液;(3) adding 80kg of pure water to the raw material extracted once again in the extraction tank, heating the extraction tank to 100 ° C and performing constant temperature extraction, the heating extraction time is 20min, after 20min, the extraction solution is poured out and bag-type filtration is adopted machine for filtration, and the secondary extraction filtrate is obtained after filtration;
(4)将一次提取滤液和二次提取滤液进行混合,并加入白砂糖180g和麦芽糖120g进行混合调味,混合后得到混合液;(4) primary extraction filtrate and secondary extraction filtrate are mixed, and 180g of white granulated sugar and 120g of maltose are added for mixing and seasoning, and the mixed solution is obtained after mixing;
(5)将混合液加热加纯净水稀释定溶,得到定溶液;(5) the mixed solution is heated and diluted with purified water to obtain a fixed solution;
(6)对定溶液进行过滤,过滤至定溶液中的可溶性固型物的含量在6%-10%,得到初级产品;(6) filter the fixed solution, filter until the content of soluble solids in the fixed solution is 6%-10%, to obtain the primary product;
(7)将初级产品灌装,灌装后在115℃-121℃的高温环境中灭菌35min,高温灭菌后即得所述天然植物解酒饮料。(7) Filling the primary product, sterilizing it in a high temperature environment of 115°C-121°C for 35 minutes after filling, and obtaining the natural plant hangover drink after high temperature sterilization.
实际病例:Actual case:
本发明保肝解酒饮料的临床疗效观察实验Observation experiment of clinical efficacy of the present invention's liver-protecting and hangover-relieving beverage
1、实验对象的一般资料:受试者40例,其中男30例,女10例;年龄最大者59岁,年龄最小者21岁。1. General information of experimental subjects: There are 40 subjects, including 30 males and 10 females; the oldest is 59 years old and the youngest is 21 years old.
2、用法用量:平均每人引用56度北京红星二锅头150-250ml,喝酒前1小时或者酒后服用本天然植物解酒饮料200-250ml。2. Usage and dosage: On average, each person cites 150-250ml of Beijing Hongxing Erguotou at 56 degrees, and 200-250ml of this natural plant hangover drink is taken 1 hour before or after drinking.
3、饮用56度北京红星二锅头。30分钟后,出现程度不同的面部发红、说话爽直等兴奋现象,有的出现平衡失调、语言不清等醉酒症状。即取本发明药物服用,用量250ml,30分钟后,症状明显减轻或消失。50分钟,症状完全消失。或者喝酒之前1小时服用本发明的天然植物解酒饮料250ml,饮用56度北京红星二锅头200ml,则无明显的不适感。3. Drink 56 degrees Beijing Red Star Erguotou. After 30 minutes, there are different degrees of excitement such as facial redness, straightforward speech, and some intoxication symptoms such as balance disorders and slurred speech. Take the medicine of the present invention and take it with a dosage of 250ml. After 30 minutes, the symptoms are obviously relieved or disappeared. Within 50 minutes, the symptoms disappeared completely. Or take 250ml of the natural plant hangover drink of the present invention one hour before drinking, and drink 200ml of 56-degree Beijing Hongxing Erguotou, there is no obvious discomfort.
4、典型案例:4. Typical case:
(1)宋某,男,42岁,司机。饮用56度北京红星二锅头,15分钟后感觉头昏,走路摇摆,胃里火烧感觉,想卧床休息。服用本发明的天然植物解酒饮料,10分钟后感到症状减轻,20分钟感觉走路不受影响,30分钟后无任何感觉。(1) Song Mou, male, 42 years old, driver. After drinking 56 degrees of Beijing Red Star Erguotou, I felt dizzy after 15 minutes, swayed when walking, felt burning in my stomach, and wanted to rest in bed. Taking the natural plant hangover drink of the present invention, the symptoms are relieved after 10 minutes, the walking is not affected after 20 minutes, and there is no feeling after 30 minutes.
(2)李某,女,53岁,退休干部。饮用56度北京红星二锅头,10分钟后感觉头昏,走路摇摆,胃里火烧感觉。服用本发明的天然植物解酒饮料,10分钟后感到症状减轻,20分钟感觉走路不受影响,30分钟后无任何感觉。(2) Li Mou, female, 53 years old, retired cadre. After drinking 56 degrees Beijing Red Star Erguotou, I felt dizzy after 10 minutes, swaying when walking, and burning in my stomach. Taking the natural plant hangover drink of the present invention, the symptoms are relieved after 10 minutes, the walking is not affected after 20 minutes, and there is no feeling after 30 minutes.
(3)胡某,女,35岁,公司职员。喝酒之前1小时先服用本发明的天然植物解酒饮料250ml,饮用56度北京红星二锅头200ml,无明显的不适感,据受试人本人自述,平时不喝本发明保肝解酒饮料时,喝56度北京红星二锅头100ml后10分钟左右便出现明显的头晕、胃部灼烧等不适感。(3) Hu Mou, female, 35 years old, employee of the company. Take 250ml of the natural plant hangover drink of the present invention 1 hour before drinking, drink 200ml of 56 degree Beijing Hongxing Erguotou, no obvious discomfort, according to the self-report of the test person, when not drinking the liver-protecting hangover drink of the present invention at ordinary times, drink After 100ml of 56 degree Beijing Red Star Erguotou, obvious dizziness, stomach burning and other discomforts will appear in about 10 minutes.
(4)钱某,男,30岁,产品经理。饮用56度北京红星二锅头400ml,10分钟后感觉胃火灼烧,恶心,呕吐,头晕明显。服用本发明的天然植物解酒饮料250ml,10分钟后感到症状减轻,胃里有凉凉感,呕吐减轻,20分钟后恶心症状消失,30分钟后无明显不适感。(4) Qian Mou, male, 30 years old, product manager. After drinking 56 degrees Beijing Hongxing Erguotou 400ml, 10 minutes later, I felt a burning stomach, nausea, vomiting, and obvious dizziness. After taking 250ml of the natural plant hangover drink of the present invention, symptoms are relieved after 10 minutes, a feeling of coolness in the stomach, and vomiting is relieved, the nausea symptoms disappear after 20 minutes, and there is no obvious discomfort after 30 minutes.
(5)赵某,男,33岁,地区经理。喝酒之前1小时先服用本发明的天然植物解酒饮料250ml,饮用56度北京红星二锅头400ml,无明显的不适感,未出现恶心、呕吐、胃火灼烧等症状,据受试人本人自述,平时不喝本发明保肝解酒饮料时,喝56度北京红星二锅头200ml后10分钟左右便出现明显的胃部灼烧、恶心、头晕等不适感。(5) Zhao Mou, male, 33 years old, regional manager. Take 250ml of the natural plant hangover drink of the present invention 1 hour before drinking, drink 400ml of 56 degrees Beijing Red Star Erguotou, no obvious discomfort, no symptoms such as nausea, vomiting, stomach fire, according to the tester himself, When not drinking the present invention's liver-protecting and hangover-relieving beverage, obvious discomforts such as stomach burning, nausea, dizziness and the like appear about 10 minutes after drinking 200ml of Beijing Hongxing Erguotou at 56 degrees.
(6)张某,男,28岁,政府公务员。喝酒之前1小时先服用本发明的天然植物解酒饮料250ml,30分钟后感觉神清气爽,饮用56度北京红星二锅头400ml,无明显的不适感,未出现恶心、呕吐、胃火灼烧、话多等症状,据受试人本人自述,平时不喝本发明保肝解酒饮料时,喝56度北京红星二锅头250ml后10分钟左右便出现明显的胃部灼烧、恶心、头晕等不适感,20分钟左右便会呕吐。(6) Zhang Mou, male, 28 years old, a government civil servant. Take 250ml of the natural plant hangover drink of the present invention 1 hour before drinking, feel refreshed after 30 minutes, drink 56 degrees Beijing Red Star Erguotou 400ml, no obvious discomfort, no nausea, vomiting, stomach fire, Symptoms such as talking too much, according to the self-report of the test person, when he does not usually drink the liver-protecting and hangover drink of the present invention, after drinking 56 degrees Beijing Hongxing Erguotou 250ml, there will be obvious stomach burning, nausea, dizziness and other discomforts in about 10 minutes. , vomiting in about 20 minutes.
实验研究Experimental Study
1.实验材料1. Experimental materials
1.1实验动物昆明种小鼠,普通级,体重22.5±2.5g,雌雄兼有,由广东省实验动物中心提供。1.1 Experimental animals Kunming mice, common grade, weighing 22.5±2.5g, both males and females, were provided by the Guangdong Provincial Laboratory Animal Center.
1.2实验物品本实验供试品由广州蓝韵医药研究有限公司提供。为原料提取液,每毫升相当于1g生药。1.2 Experimental items The test items in this experiment were provided by Guangzhou Lanyun Pharmaceutical Research Co., Ltd. As the raw material extract, each milliliter is equivalent to 1g of crude drug.
1.3主要试剂考马斯亮兰蛋白测定试剂盒、微量丙二醛(MDA)N定试剂盒、还原型谷胱甘肽(GSH)测定试剂盒。1.3 Main reagents Coomassie brilliant blue protein assay kit, trace malondialdehyde (MDA) N assay kit, reduced glutathione (GSH) assay kit.
1.4实验仪器722s型分光光度计、电子天平。1.4 Experimental instruments 722s type spectrophotometer, electronic balance.
2.实验方法2. Experimental method
2.1分组及给药方法实验小鼠50只,随机分成5组,每组10只。分别为给药低、中、高组(1、2、4g/kg),阳性对照组和模型对照组。均ig给药。模型组ig等体积的生理盐水。2.1 Grouping and administration method 50 experimental mice were randomly divided into 5 groups with 10 mice in each group. They were the low, medium and high administration groups (1, 2, 4 g/kg), the positive control group and the model control group, respectively. Both were administered ig. The model group received an equal volume of normal saline.
2.2预防醉酒实验实验前禁食12小时,各组分别给药。给药2小时后,各组均ig38度白酒(15mL/kg)。观察记录各组小鼠翻正反应消失时间(醉酒时间)和恢复时间(醒酒时间)。结果见表1。2.2 Prevention of drunkenness experiment Fasting for 12 hours before the experiment, each group was administered separately. Two hours after administration, each group was given 38 degree white wine (15mL/kg). The disappearance time (drunk time) and recovery time (sober time) of the mice in each group were observed and recorded. The results are shown in Table 1.
2.3攀附实验实验前禁食12小时,各组分别给药。给药2小时后,各组均ig38度白酒(7.5mL/kg)。小鼠立即兴奋,并出现行动失常现象,但翻正反应仍存在,则为醉前反应。将小鼠放在垂直的金属网上,记录小鼠攀附在网上的时间。观察受试品对小鼠酒后运动失调的纠正作用。结果见表2.2.3 Climbing experiment Fasting for 12 hours before the experiment, each group was administered separately. After 2 hours of administration, each group was given 38 degree white wine (7.5mL/kg). The mice were immediately excited and acted erratically, but the righting response still existed, which was the pre-drunk reaction. The mice were placed on a vertical metal net and the time that the mice clinged to the net was recorded. To observe the corrective effect of the test article on the alcohol-induced ataxia in mice. The results are shown in Table 2.
2.4对酒精性肝损伤的影响给药前,各组均ig38度白酒(15mL/kg),然后给药,6h后处死各组小鼠,立即取肝右叶的一小块肝组织,加4℃生理盐水制成10%的肝匀浆。2000r/min离心10分钟,分取上清液,测定谷胱甘肽(GSH)和丙二醛(MDA)的含量。结果见表3。2.4 Effect on alcoholic liver injury Before administration, each group was given 38 degree white wine (15mL/kg), and then administered. After 6 hours, the mice in each group were killed, and a small piece of liver tissue from the right lobe of the liver was immediately taken and added with 4 10% liver homogenate was prepared in normal saline. Centrifuge at 2000 r/min for 10 minutes, separate the supernatant, and measure the content of glutathione (GSH) and malondialdehyde (MDA). The results are shown in Table 3.
2.5统计学处理数据以±s表示,应用SPSS12.0统计软件包进行处理。组问比较采用方差分析,P<0.05有统计学意义。2.5 Statistical processing Data are expressed as ±s, and processed using SPSS12.0 statistical software package. Group comparisons were made by analysis of variance, and P<0.05 was considered statistically significant.
3.实验结果3. Experimental results
见表1~3。See Tables 1-3.
表1各组小鼠翻正反射消失的时间和恢复(n=10)Table 1 Time and recovery of the disappearance of righting reflex of mice in each group ( n=10)
与模型组对照比较,*P<0.01。Compared with the model group control, *P<0.01.
结果显示,给药各组和阳性对照组可明显延长发生醉酒时间和缩短醒酒时间(P<0.01),且给药组随着剂量的增加效果越好,但中剂量组和高剂量之间并无显著性差异(P>0.05)。The results showed that the administration groups and the positive control group could significantly prolong the time of intoxication and shorten the time to sober up (P<0.01), and the administration group had better effect with the increase of the dose, but there was no difference between the middle-dose group and the high-dose group. There was no significant difference (P>0.05).
表明本植物饮料能显著延长发生醉酒的时间和缩短醉酒时间,且中、高剂量之间没有显著性差异。The results indicated that the plant beverage could significantly prolong the time of intoxication and shorten the time of intoxication, and there was no significant difference between the middle and high doses.
表2给药后小鼠动作失调的纠正作用(n=10)Table 2 Correction of dyskinesia in mice after administration ( n=10)
与模型组对照比较,*P<0.01。Compared with the model group control, *P<0.01.
结果显示,给药各组和阳性对照组攀爬时间均显著长于模型组,以给药高剂量最佳。实验结果表明,本植物饮料能改善小鼠饮醉酒导致的动作失调,中、高剂量效果一致,且略优于阳性对照组。The results showed that the climbing time of each administration group and the positive control group was significantly longer than that of the model group, and the highest dose was the best. The experimental results show that this plant drink can improve the movement disorders caused by drunken drinking in mice.
表3给药后对小鼠肝损伤的影响(n=10)The effects of table 3 administration on liver injury in mice ( n=10)
与模型组对照比较,*P<0.05。Compared with the model group control, *P<0.05.
结果显示,给药各组均能显著降低肝脏中的MDA,阳性对照组及给药中、高剂量组能升高肝脏中的GSH,但给药低剂量组未能使GSH含量升高。综合实验结果可以看出,本天然植物解酒饮料能显著延长小鼠发生醉酒的时间能明显缩短醉酒时间,对醉酒导致的动作失调有显著的纠正作用,同时还能降低小鼠醉酒后肝脏中的MDA含量,并升高GSH的含量。实验结果还显示上述作用跟剂量有关,中、高剂量结果一致且均优于低剂量。The results showed that administration of each group could significantly reduce MDA in liver, positive control group and administration of medium and high dose groups could increase GSH in liver, but administration of low dose group failed to increase GSH content. From the comprehensive experimental results, it can be seen that the natural plant hangover drink can significantly prolong the time of intoxication in mice, shorten the time of intoxication, and significantly correct the movement disorders caused by intoxication, and at the same time, it can reduce the amount of alcohol in the liver of mice after drunkenness. MDA content, and increased GSH content. The experimental results also show that the above effects are related to the dose, and the results of medium and high doses are consistent and better than those of low doses.
本说明书中各个实施例采用递进的方式描述,每个实施例重点说明的都是与其他实施例的不同之处,各个实施例之间相同相似部分互相参见即可。对于实施例公开的装置而言,由于其与实施例公开的方法相对应,所以描述的比较简单,相关之处参见方法部分说明即可。The various embodiments in this specification are described in a progressive manner, and each embodiment focuses on the differences from other embodiments, and the same and similar parts between the various embodiments can be referred to each other. For the device disclosed in the embodiment, since it corresponds to the method disclosed in the embodiment, the description is relatively simple, and the relevant part can be referred to the description of the method.
对所公开的实施例的上述说明,使本领域专业技术人员能够实现或使用本发明。对这些实施例的多种修改对本领域的专业技术人员来说将是显而易见的,本文中所定义的一般原理可以在不脱离本发明的精神或范围的情况下,在其它实施例中实现。因此,本发明将不会被限制于本文所示的这些实施例,而是要符合与本文所公开的原理和新颖特点相一致的最宽的范围。The above description of the disclosed embodiments enables any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (7)
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CN113768153A (en) * | 2021-09-14 | 2021-12-10 | 浙江省农业科学院 | Anti-alcohol composition, preparation method and application thereof |
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