CN1119116A - Medicine for curing angiocardiopathy and cerebrovascular diseases and preparing process thereof - Google Patents

Abstract

The medicine for prevention and cure of cardiovascular and cerebrovascular diseases is prepared from 8 Chinese-medicinal materials such as toad venom, leech, American ginseng, rhubarb, borneol, etc. through grinding, immersion in water, alcohol extraction, mixing, and loading powder in capsules.

Description

A kind of medicine that is used for the treatment of cardiovascular and cerebrovascular disease and preparation method thereof

The present invention relates to a kind of medicine that is used for the treatment of cardiovascular and cerebrovascular disease and preparation method thereof, belong to traditional Chinese medical science pharmaceutical products technical field.

Numeral according to World Health Organization's statistics announcement, cardiovascular and cerebrovascular disease has become the healthy principal disease of harm contemporary mankind, for this reason, the spirit of healing the wounded and rescue the dying is carried forward on each road, the elite that are good at Chinese medicine contribute the medication that much suits in clinical diagnosis and treatment, such as HUOLUO WAN, FUFANG DANSHEN PIAN, SHANHAI PILL, the health of being bestowed by heaven, the bright Soviet Union of the heart etc.These medicines are used for the clinical different therapeutic effect of all having obtained.Yet, it all is not Kang Ercheng of the long-pending heart, gas, blood, essence that the clinical manifestation of cardiovascular and cerebrovascular disease chases after its root, the formation that is to say above-mentioned disease is that human body viscera can not obtain good health care, long-term overwork and long-pending disease becomes disease, therefore, at clinical treatment, in conjunction with the problem of health care on ordinary days by numerous medical personnels be considered as main dive direction and constantly propose new therapeutic scheme and new in, western modern medicine.

The purpose of this invention is to provide a kind of medicine that is used for the treatment of cardiovascular and cerebrovascular disease, it forms with eight flavor Chinese medicine prescriptions such as Venenum Bufonis, thereby and forms the new property of medicine with the compatibility relationship between each flavor medicine and be beneficial to the purpose that the heart, gas, the blood to human body, the capable across-the-board regulation that progresses greatly reach diseases prevention, cure the disease.

The object of the present invention is achieved like this: medicine of the present invention is the capsule of being made by Venenum Bufonis, Hirudo, Radix Panacis Quinquefolii, Radix Et Rhizoma Rhei, Borneolum Syntheticum, the Radix Astragali, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae eight flavor Chinese medicines, and the prescription of this eight flavors medicine by adult's daily dose is:

Venenum Bufonis 0.0006-0.0009g, Hirudo 0.0g-0.1g,

Radix Panacis Quinquefolii 2-3g, Radix Et Rhizoma Rhei 2-3g,

Borneolum Syntheticum 0.03-0.06g, Radix Astragali 2-3g,

Rhizoma Chuanxiong 2-3g, Radix Salviae Miltiorrhizae 2-3g.

Can adjust in right amount by its proportion relation above-mentioned prescription.

The realization manufacturing method for above mentioned medicine is:

1. the Radix Astragali, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae three flavor coarse powder are broken into crude drug, add water retting then and water liquid level group medicine is ten hours, next day, reflux, extract, was 2 times, each 3 hours, filter, concentrate to such an extent that proportion be 1.00 to 1.10 aqueous extract through crocus cloth secondary raffinate afterwards, again with the medicinal residues behind the water extraction respectively with Different concentrations of alcohol aqueous solution reflux, extract,, each 1.5-2 hour, merge each ethanol water extracting solution afterwards, reclaim ethanol through precipitation, filtration, normal pressure then, must not have the rare extractum of alcohol flavor;

2. Radix Panacis Quinquefolii is pulverized simply and ground to the powder again and above-mentioned aqueous extract, do not have the rare extractum of alcohol flavor and be combined into a place and between temperature 75-90 ℃, stir, mixing time is 1.5-3 hour, obtain under 45-65 ℃ temperature conditions, carrying out drying again behind the thick paste and get dry extract, pulverize and cross 120 mesh sieves afterwards and get fine end;

3. Venenum Bufonis, Hirudo, Borneolum Syntheticum, Radix Et Rhizoma Rhei four flavors are pulverized and ground to the powder again and the abundant mixing in above-mentioned fine end, encapsulated afterwards.

Because the eight flavor Chinese medicines that the present invention relates to have respectively: Venenum Bufonis---can play the heart tonifying promoting blood circulation and detumescence, micro-informal dress and do not have the evil of being harmful to the health; Hirudo---can play removing blood stasis with potent drugs blood, pursue the effect of gathering, informal dress can be removed blood vessel inner product polymers and dissipation abnormal pigmentary deposit on the skin trace; Borneolum Syntheticum---can play heart tonifying and relieving palpitation effect; Radix Et Rhizoma Rhei---can play the diarrhea effect, have rubbish in the human body of elimination, strengthen the effect of human immunity, but the informal dress life lengthening; Radix Panacis Quinquefolii---it is not hot-tempered to enrich blood, but supplementing QI for promoting the production of body fluid; But the reinforcing and reducing of associating with of the Radix Astragali---QI invigorating, diuresis, the warm in nature and cold temperature of Radix Et Rhizoma Rhei match, and informal dress only does good, not harm; Radix Salviae Miltiorrhizae---blood circulation and promoting silt pain relieving; Rhizoma Chuanxiong---can play removing blood stasis with potent drugs blood, the blood that nourishes heart, broken caking.Therefore, the capsule that is prepared from according to above-mentioned Chinese prescription has heart tonifying, QI invigorating, invigorates blood circulation, blood stasis dispelling, impel blood flow vigorous and remove effect outside blood vessel with accumulating material in the blood vessel, also can play the hardened effect of health care cardiovascular and cerebrovascular vessel prevention of arterial simultaneously.

Below in conjunction with embodiment and prepare the method for new drug the present invention is described in further detail:

Embodiment:

Prescription is formed:

Venenum Bufonis 0.00075g, Hirudo 0.095g,

Radix Panacis Quinquefolii 2.5g, Radix Et Rhizoma Rhei 2.5g,

Borneolum Syntheticum 0.045g, Radix Astragali 2.5g,

Rhizoma Chuanxiong 2.5g, Radix Salviae Miltiorrhizae 2.5g.

Preparation method:

First that the Radix Astragali, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae three flavor coarse pulverizations and mistake 20 mesh sieves are standby;

It is standby Radix Panacis Quinquefolii to be pulverized simply 100 mesh sieves that grind to the powder again;

120 mesh sieves that again Venenum Bufonis, Hirudo, Borneolum Syntheticum, Radix Et Rhizoma Rhei four flavor pulverizing ground to the powder are standby;

1. after, the Radix Astragali, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae three flavor coarse pulverization crude drugs are added water retting and water liquid level group medicine is 10 hours, next day, reflux, extract, was 2 times, each 3 hours, filtered to such an extent that spissated proportion be 1.00 to 1.10 aqueous extract through crocus cloth the extracting solution of this secondary then; Again with the medicinal residues of above-mentioned aqueous extract respectively with the ethanol water reflux, extract, of variable concentrations (can be respectively 55%, 65%, 75%, 85%, 95%), each 1.5-2 hour; Merge each ethanol water extracting solution then, reclaim ethanol through precipitation, filtration, normal pressure again and must not have the rare extractum of alcohol flavor;

2. with above-mentioned Radix Panacis Quinquefolii simply smalls and above-mentioned aqueous extract, do not have the rare extractum of alcohol flavor and be combined into one and be in evenly to stir under the heating state and close, temperature can maintain between 75-90 ℃, mixing time be 1.5-3 hour thick paste, again thick paste is placed dry vessel to carry out drying, baking temperature is 45-65 ℃, get dry extract, and dried cream is carefully ground 120 mesh sieve smalls;

3. it is full and uniform at last Venenum Bufonis, Hirudo, Borneolum Syntheticum, Radix Et Rhizoma Rhei four flavor smalls and dried cream smalls to be combined into a place, gets former medicated powder, divides packing with every capsule 0.5 gram amount again.Except that above-mentioned preparation method, if with this medicine make red ball only need dried cream smalls and Venenum Bufonis, Hirudo, Borneolum Syntheticum, Radix Et Rhizoma Rhei four flavor smalls thick and rub ball with the hands and get final product with Mel, also can with add behind dried cream smalls and Venenum Bufonis, Hirudo, Borneolum Syntheticum, the Radix Et Rhizoma Rhei four flavor smalls uniform mixing dextrin or starch make soft material more respectively certain mesh sieve go into tablet machine and make tablet.

The present invention takes from natural Chinese medicines fully, except that above-mentioned effect, and example surplus the clinical observation 300, at the treatment cardiovascular and cerebrovascular disease, especially the statistics of arteries disease aspect is:

Effective percentage is more than 96%;

Cure rate is more than 90%.

If take the effect that this medicine can play health care human body, the generation of prevention blood cerebrovascular disease for a long time.

Accompanying drawing is preparation technology's flow chart of medicine of the present invention.

Claims (5)

1, a kind of medicine that is used for the treatment of cardiovascular and cerebrovascular disease is characterized in that it is the capsule of being made by Venenum Bufonis, Hirudo, Radix Panacis Quinquefolii, Radix Et Rhizoma Rhei, Borneolum Syntheticum, the Radix Astragali, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae eight flavor Chinese medicines.

2, a kind of medicine that is used for the treatment of cardiovascular and cerebrovascular disease according to claim 1 is characterized in that the prescription of said medicine by adult's daily dose is:

Venenum Bufonis 0.0006-0.0009g, Hirudo 0.09-0.1g,

Radix Panacis Quinquefolii 2-3g, Radix Et Rhizoma Rhei 2-3g,

Borneolum Syntheticum 0.03-0.06g, Radix Astragali 2-3g,

Rhizoma Chuanxiong 2-3g, Radix Salviae Miltiorrhizae 2-3g.

3, according to claim 1,2 described a kind of medicines that are used for the treatment of cardiovascular and cerebrovascular disease, it is characterized in that the prescription optimum amount proportioning of said medicine is:

Venenum Bufonis 0.00075g, Hirudo 0.095g,

Radix Panacis Quinquefolii 2.5g, Radix Et Rhizoma Rhei 2.5g,

Borneolum Syntheticum 0.045g, Radix Astragali 2.5g,

Rhizoma Chuanxiong 2.5g, Radix Salviae Miltiorrhizae 2.5g.

4, according to claim 1,2,3 described a kind of preparation methoies that are used for the treatment of the medicine of cardiovascular and cerebrovascular disease, it is characterized in that: 1. with the Radix Astragali, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae three flavor coarse powder are broken into crude drug, add water retting then and water liquid level group medicine is ten hours, next day, reflux, extract, was 2 times, each 3 hours, afterwards secondary raffinate is filtered through crocus cloth, concentrate to such an extent that proportion is 1.00 to 1.10 aqueous extract, again with the medicinal residues behind the water extraction respectively with Different concentrations of alcohol aqueous solution reflux, extract, each 1.5-2 hour, merge each ethanol water extracting solution afterwards, then through precipitation, filter, normal pressure reclaims ethanol, must not have the rare extractum of alcohol flavor;

2. Radix Panacis Quinquefolii is pulverized simply and ground to the powder again and above-mentioned aqueous extract, do not have the rare extractum of alcohol flavor and be combined into a place and between temperature 75-90 ℃, stir, mixing time is 1.5-3 hour, obtain getting dry extract in 45-65 ℃ of drying again behind the thick paste, pulverize and cross 120 mesh sieves afterwards and get fine end;

3. Venenum Bufonis, Hirudo, Borneolum Syntheticum, Radix Et Rhizoma Rhei four flavors are pulverized and ground to the powder again and the abundant mixing in above-mentioned fine end, encapsulated afterwards.

5, a kind of preparation method that is used for the treatment of the medicine of cardiovascular and cerebrovascular disease according to claim 4, it is characterized in that can add Mel at the mixing smalls after above-mentioned eight flavors obtain after preparing separately is prepared into ball, also can add excipient and be prepared into tablet.

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