CN111888272A - Application of flavonol in cosmetics - Google Patents
Application of flavonol in cosmetics Download PDFInfo
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- CN111888272A CN111888272A CN202010745771.9A CN202010745771A CN111888272A CN 111888272 A CN111888272 A CN 111888272A CN 202010745771 A CN202010745771 A CN 202010745771A CN 111888272 A CN111888272 A CN 111888272A
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- flavonol
- catalpa
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- Bioinformatics & Cheminformatics (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses an application of flavonol in cosmetics, and a preparation method of the flavonol comprises the following steps: the method comprises the following steps: drying the cleaned catalpa ovata fruits at low temperature, crushing after drying and filtering; step two: adding the crushed catalpa fruits into ethanol for leaching, and refluxing the mixed solution of the catalpa fruits after leaching; step three: carrying out centrifugal reaction on the refluxed catalpa fruit mixed solution, and taking supernatant after centrifugation to obtain a flavone extracting solution; step four: heating and concentrating the flavone extract to obtain crude flavone; step five: dropping the crude flavone obtained in the fourth step into hydrogen peroxide for decoloring; step six: filtering the crude flavone subjected to the decolorization treatment in the fifth step through a 0.35 mu m filter membrane to obtain the required flavonoid compound; step seven: can be used in cosmetics. The method utilizes the catalpa fruit raw material to extract the flavonol, so that the flavonol can be more conveniently extracted, the extraction efficiency is higher, and meanwhile, the effects of bacteriostasis, heat clearing, detoxifying and the like can be used for acne removing products.
Description
Technical Field
The invention relates to the technical field of application of flavonol, in particular to application of flavonol in cosmetics.
Background
The cosmetics refer to chemical industrial products or fine chemical products which are scattered on any parts of the surface of a human body, such as skin, hair, nails, lips and teeth, by smearing, spraying or other similar methods so as to achieve the purposes of cleaning, maintaining, beautifying, modifying and changing the appearance, or correcting the smell of the human body and keeping a good state, and the cosmetics are generally divided into skin care type, basic type, beauty type, curative effect type and the like according to the using effect, and are widely applied in practice;
the flavonoid compounds are also called flavonoid bodies and flavonones and are a large class of natural phenolic compounds widely distributed in the natural world, particularly in the plant world, in recent years, the biological action and the application value of the natural flavonoid compounds are more and more important, catalpa ovata belongs to catalpa plants in the Bignoniaceae, fruits of the catalpa ovata have the medicinal functions of clearing heat, detoxifying and the like and are used for treating ascites due to cirrhosis, but due to the fact that the material basis is not clear enough, the catalpa ovata is not loaded into pharmacopoeia till now, and fruits, leaves and flowers in the catalpa ovata all contain the flavonoid compounds, wherein the total flavonoid content in the fruits is highest in different parts of the catalpa ovata, and the flavonoid components in the catalpa ovata can.
At present, different plant and berry extraction modes are adopted for the application of flavonol in cosmetics, the operation link is relatively complex, the extraction efficiency is insufficient, the production cost is correspondingly increased, and a certain improvement space exists.
Disclosure of Invention
The invention mainly aims to provide an application of flavonol in cosmetics, and aims to solve the problems that the prior method for extracting the flavonol by adopting different plants and berries has relatively complex operation links, insufficient extraction efficiency, correspondingly increased production cost and the like.
In order to achieve the purpose, the invention adopts the technical scheme that: the application of flavonol in cosmetics includes the following steps:
the method comprises the following steps: drying the cleaned catalpa ovata fruits at low temperature, crushing after drying and filtering;
step two: adding the crushed catalpa fruits into ethanol for leaching, and refluxing the mixed solution of the catalpa fruits after leaching;
step three: carrying out centrifugal reaction on the refluxed catalpa fruit mixed solution, and taking supernatant after centrifugation to obtain a flavone extracting solution;
step four: heating and concentrating the flavone extract to obtain crude flavone;
step five: dropping the crude flavone obtained in the fourth step into hydrogen peroxide for decoloring;
step six: filtering the crude flavone subjected to the decolorization treatment in the fifth step through a 0.35 mu m filter membrane to obtain the required flavonoid compound;
step seven: applying the flavonoid compound obtained in the sixth step to cosmetics, adding a proper amount of the flavonoid compound into the rest homogenized cosmetic components, fully stirring and melting, and heating for sterilization;
step eight: standing the mixed cosmetic components.
Preferably, in the first step, the low-temperature drying temperature of the fresh catalpa ovata fruits is 55-65 ℃, the drying time is 25-35min, and the crushing time after drying is 3-5min, so that the particle size of the catalpa ovata fruits is 50 meshes.
Preferably, the second step is carried out by using 60% ethanol for extraction, the extraction time is 2h, the temperature is kept at 70 ℃, and the material-liquid ratio is 1:20 g: ml.
Preferably, the mixed solution of the catalpa ovata fruits in the third step is subjected to a centrifugal reaction by a centrifugal machine, and the centrifugal reaction time of the solution is 10-15 min.
Preferably, the heating temperature of the flavone extracting solution in the step four is 70-80 ℃, the heating time is 0.8-1h, and the flavone extracting solution is concentrated.
Preferably, the using concentration of the hydrogen peroxide in the step five is 30%, the crude flavone is dripped, and the decoloring reaction time of the crude flavone is 2-3 min.
Preferably, the flavonoid compound is added with the rest cosmetic ingredients in the step seven, the flavonoid compound is stirred while being added, meanwhile, the flavonoid compound is heated in the stirring process, the rotating speed is kept at 120rpm in the stirring process, the heating temperature is kept at 85-95 ℃, 0.5 percent of antibacterial agent is added, and the flavonoid compound is continuously stirred for 25-35 min.
Preferably, the cosmetics after the completion of the fusion in the step eight are kept still for 6-8h to obtain the cosmetics containing the flavonol components.
Preferably, step nine: and (5) observing the cosmetic ingredients after standing in the step eight, wherein no bubbles are generated on the surface of the cosmetic ingredients, and the cosmetic ingredients need to be continuously kept standing in a bubble-containing state until the bubbles disappear.
The invention has the following beneficial effects:
the method utilizes the catalpa fruit raw material to extract the flavonol, so that the flavonol can be more conveniently extracted, the extraction efficiency is higher, and the effects of bacteriostasis, heat clearing and detoxifying can be used for acne removing products.
Compared with other products, the method has the advantages of simple operation, low production cost and the like, and has high market popularization value.
Of course, it is not necessary for any product in which the invention is practiced to achieve all of the above-described advantages at the same time.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The application of flavonol in cosmetics includes the following steps:
the method comprises the following steps: drying the cleaned catalpa ovata fruits at low temperature, crushing after drying and filtering;
step two: adding the crushed catalpa fruits into ethanol for leaching, and refluxing the mixed solution of the catalpa fruits after leaching;
step three: carrying out centrifugal reaction on the refluxed catalpa fruit mixed solution, and taking supernatant after centrifugation to obtain a flavone extracting solution;
step four: heating and concentrating the flavone extract to obtain crude flavone;
step five: dropping the crude flavone obtained in the fourth step into hydrogen peroxide for decoloring;
step six: filtering the crude flavone subjected to the decolorization treatment in the fifth step through a 0.35 mu m filter membrane to obtain the required flavonoid compound;
step seven: applying the flavonoid compound obtained in the sixth step to cosmetics, adding a proper amount of the flavonoid compound into the rest homogenized cosmetic components, fully stirring and melting, and heating for sterilization;
step eight: standing the mixed cosmetic components.
Wherein the low-temperature drying temperature of the fresh catalpa ovata fruits in the step one is 55-65 ℃, the drying time is 25-35min, and the crushing time after drying is 3-5min, so that the particle size is 50 meshes.
Wherein, in the second step, 60 percent ethanol is used for extraction, the extraction time is 2 hours, the temperature is kept at 70 ℃, and the material-liquid ratio is 1:20 g: ml.
Wherein, the mixed solution of the catalpa ovata fruits in the three steps adopts a centrifuge to carry out centrifugal reaction, and the centrifugal reaction time of the solution is 10-15 min.
Wherein the heating temperature of the flavone extracting solution in the step four is 70-80 ℃, the heating time is 0.8-1h, and the flavone extracting solution is concentrated.
Wherein, the using concentration of the hydrogen peroxide in the step five is 30 percent, the crude flavone is dripped, and the decoloring reaction time of the crude flavone is 2-3 min.
Wherein, the flavonoid compound is added with the rest cosmetic ingredients in the step seven, the flavonoid compound is stirred while being added, meanwhile, the flavonoid compound is heated in the stirring process, the rotating speed is kept at 120rpm in the stirring process, the heating temperature is kept at 85-95 ℃, 0.5 percent of antibacterial agent is added, and the flavonoid compound is continuously stirred for 25-35 min.
Wherein, the cosmetics after the fusion in the step eight are kept stand for 6-8h to obtain the cosmetics containing the flavonol component.
Wherein, the ninth step: and (5) observing the cosmetic ingredients after standing in the step eight, wherein no bubbles are generated on the surface of the cosmetic ingredients, and the cosmetic ingredients need to be continuously kept standing in a bubble-containing state until the bubbles disappear.
Example 2
Aiming at the application of the flavonol of the invention in cosmetics, by comparing the leaching rates of flavone extracted from rape pollen and south dodder, respectively taking 500g of catalpa fruits, 500g of rape pollen and 500g of south dodder as A, B and C, respectively, taking the catalpa fruits as A group, taking the rape pollen as B group and taking the south dodder as C group, wherein the method for extracting flavone from the catalpa fruits adopts the invention, the rape pollen and the south dodder adopt respective adaptive extraction modes, the reaction medium is usually ethyl acetate, and the extraction amounts and the leaching rates of the flavone of the three groups of products are compared through the extraction results, and the conditions are shown in the following table.
Table one shows the comparison of the recovery and extraction rate of flavone for 3 groups of products:
as can be seen from Table 1, the extraction recovery amount and the extraction rate of the flavone extract are obviously higher than those of other two products, and the utilization efficiency of the flavonol in the cosmetics is higher.
Example 3
The product is subjected to an antioxidant experiment and a bacteriostatic experiment respectively, and the obtained conclusion is as follows:
antioxidant experiments show that the flavonoid compounds in the catalpa ovata fruits have better removal effect on hydroxyl free radicals and superoxide anions;
bacteriostatic experiments show that the flavonoid compounds in the catalpa fruits have better inhibitory action on bacillus thuringiensis and bacillus subtilis.
In addition, the volatile oil of catalpa flowers is extracted by a steam distillation method and analyzed by GC-MS, and 32 compounds are identified, wherein the relative content of the components is more than 5 percent, namely phenanthrene (27.21 percent), fluorene (7.71 percent), forty-alkyl (6.17 percent) and tetracosan (6.05 percent).
In the description herein, references to the description of "one embodiment," "an example," "a specific example" or the like are intended to mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The preferred embodiments of the invention disclosed above are intended to be illustrative only. The preferred embodiments are not intended to be exhaustive or to limit the invention to the precise embodiments disclosed. Obviously, many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, to thereby enable others skilled in the art to best utilize the invention. The invention is limited only by the claims and their full scope and equivalents.
Claims (9)
1. The application of flavonol in cosmetics is characterized in that the preparation method comprises the following steps:
the method comprises the following steps: drying the cleaned catalpa ovata fruits at low temperature, crushing after drying and filtering;
step two: adding the crushed catalpa fruits into ethanol for leaching, and refluxing the mixed solution of the catalpa fruits after leaching;
step three: carrying out centrifugal reaction on the refluxed catalpa fruit mixed solution, and taking supernatant after centrifugation to obtain a flavone extracting solution;
step four: heating and concentrating the flavone extract to obtain crude flavone;
step five: dropping the crude flavone obtained in the fourth step into hydrogen peroxide for decoloring;
step six: filtering the crude flavone subjected to the decolorization treatment in the fifth step through a 0.35 mu m filter membrane to obtain the required flavonoid compound;
step seven: applying the flavonoid compound obtained in the sixth step to cosmetics, adding a proper amount of the flavonoid compound into the rest homogenized cosmetic components, fully stirring and melting, and heating for sterilization;
step eight: standing the mixed cosmetic components.
2. The cosmetic application of flavonol according to claim 1, wherein the low temperature drying temperature of fresh catalpa fruit in step one is 55-65 ℃, the drying time is 25-35min, and the crushing time after drying is 3-5min, so that the particle size is 50 meshes.
3. The cosmetic application of flavonol of claim 1, wherein in step two, 60% ethanol is used for extraction, the extraction time is 2h, the temperature is kept at 70 ℃, and the ratio of material to liquid is 1:20 g: ml.
4. The application of flavonol in cosmetics as claimed in claim 1, wherein the step of centrifuging the mixed solution of catalpa ovata fruits with a centrifuge lasts for 10-15 min.
5. The use of a flavonoid extract in cosmetics according to claim 1, wherein the temperature of the flavonoid extract solution in step four is 70-80 ℃ and the heating time is 0.8-1h, and the flavonoid extract solution is concentrated.
6. The cosmetic application of flavonol of claim 1, wherein in step five, the use concentration of hydrogen peroxide is 30%, crude flavone is dripped, and the decolorization reaction time of the crude flavone is 2-3 min.
7. The use of a flavonoid compound in cosmetics according to claim 1, wherein in step seven, the flavonoid compound is added to the remaining cosmetic ingredients while stirring, and simultaneously heated during stirring, wherein the rotation speed is maintained at 100-120rpm during stirring, the heating temperature is maintained at 85-95 ℃, 0.5% of an antibacterial agent is added, and the stirring is continued for 25-35 min.
8. The use of flavonol according to claim 1, wherein the cosmetic after completion of the fusion in step eight is allowed to stand for 6-8 hours to obtain a cosmetic containing flavonol components.
9. The cosmetic use of flavonol according to claim 1, wherein the method comprises the following nine steps: and (5) observing the cosmetic ingredients after standing in the step eight, wherein no bubbles are generated on the surface of the cosmetic ingredients, and the cosmetic ingredients need to be continuously kept standing in a bubble-containing state until the bubbles disappear.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010745771.9A CN111888272A (en) | 2020-07-29 | 2020-07-29 | Application of flavonol in cosmetics |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010745771.9A CN111888272A (en) | 2020-07-29 | 2020-07-29 | Application of flavonol in cosmetics |
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| CN111888272A true CN111888272A (en) | 2020-11-06 |
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| CN202010745771.9A Pending CN111888272A (en) | 2020-07-29 | 2020-07-29 | Application of flavonol in cosmetics |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002034183A1 (en) * | 2000-10-25 | 2002-05-02 | Kimberly-Clark Worldwide, Inc. | Toilet training article containing an astringent agent |
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- 2020-07-29 CN CN202010745771.9A patent/CN111888272A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002034183A1 (en) * | 2000-10-25 | 2002-05-02 | Kimberly-Clark Worldwide, Inc. | Toilet training article containing an astringent agent |
Non-Patent Citations (2)
| Title |
|---|
| 宫玉婷等: "树果实中黄酮类化合物提取工艺研究", 《食品科学》 * |
| 杨文慧;胡敏;杨梅;王文;刘芳兵;陈洪卫;徐文进;巩江;倪士峰;: "梓树药学研究概况", 安徽农业科学 * |
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Application publication date: 20201106 |