CN111743621A - An invasive electrode for irreversible electroporation of esophageal tumor tissue - Google Patents

Abstract

The invention discloses an invasive electrode for irreversible electroporation therapy of esophageal tumor tissues, which comprises: the electrode comprises a fixed shell, a sheath, an electrode wire and an electrode; the fixed shell is provided with a traction mechanism, an electrode fixing ring is arranged in the accommodating cavity in a sliding manner, one end of the electrode fixing ring is connected with an electrode, the other end of the electrode fixing ring is abutted against one end of an elastic element, and the other end of the elastic element is abutted against the electrode sheath; the electrode wire penetrates through the sheath and the electrode sheath, one end of the electrode wire is connected with the traction mechanism, and the other end of the electrode wire is connected with the electrode or the electrode fixing ring. The invasive electrode for irreversible electroporation treatment of esophageal tumor tissues can realize non-invasive, accurate and convenient irreversible electroporation electrode arrangement, greatly reduce the difficulty of operating instruments during treatment, is very suitable for the treatment of esophageal cancer, and greatly reduces the risk of operation of patients.

Description

An invasive electrode for irreversible electroporation of esophageal tumor tissue

technical field

The invention relates to an invasive electrode for irreversible electroporation treatment of esophageal tumor tissue

Background technique

Irreversible electroporation (IRE) ablation technology uses a high-voltage pulsed electric field to act on tissue cells, so that the cell membrane is perforated under the action of electric potential, destroying the homeostasis of cells, thereby causing cell death, and is mainly used for tumor treatment. The process of IRE ablation treatment is mainly to apply high-voltage pulses to a specific range of tissues through electrodes, so as to achieve the purpose of inactivating tumor cells without affecting normal cells. The current electrodes are mainly divided into two types: needle electrodes and flat electrodes.

Needle electrodes such as NanoKnife (Fritz S, Sommer CM, Vollherbst D, et al. Irreversible electroporation of the pancreas isfeasible and safe in a porcine survival model. Pancreas. 2015,44(5):791- 798), the electrodes were inserted into the tumor tissue in parallel, and the size of the action range was controlled by changing the electrode spacing and the depth of insertion into the tumor tissue. The flat electrode is to place the tumor tissue between two parallel electrodes, and only ablate the tissue between the electrodes (Rombouts SJE, van Dijck WPM, Nijkamp MW, et al. Clinical and pathological outcomes after irreversible electroporation of the pancreas). using two parallel plate electrodes: a porcine model. HPB (Oxford). 2017, 19(12): 1058-1065).

At present, these two electrodes are mainly used in tumors of solid organs such as liver, pancreas, and kidney. However, the application of hollow organs such as esophagus is less, and only the application of flat electrodes on esophageal tissue has been reported (Neven K. , van Es R, van Driel V, et al. Acute and Long-Term Effects of Full-Power ElectroporationAblation Directly on the Porcine Esophagus. Circ Arrhythm Electrophysiol. 2017, 10(5).pii:e004672). Moreover, the existing two electrodes have obvious shortcomings. On the one hand, the application of the existing electrodes needs to expose the organs to facilitate the arrangement of the electrodes, which is more traumatic to the patient, and the tumor patients themselves are relatively weak, and their functions are somewhat different. In addition, the existing needle electrodes can be placed under real-time monitoring by ultrasound or CT through percutaneous puncture. The process is complicated and time-consuming. As a hollow organ, the esophagus has a special anatomical structure, is deep, and is adjacent to important organs such as the heart. Only using the existing electrodes for IRE ablation has great risks. In addition, since there is no serosal layer in the outer layer of the esophagus, a little carelessness in the invasive ablation treatment can easily lead to poor wound healing and the occurrence of esophageal fistula, causing unnecessary injuries. The two existing methods are difficult to apply on the esophagus, and neither can guarantee the non-invasiveness of esophageal IRE ablation.

Therefore, according to the organ characteristics of the esophagus, it is of great significance to design a unique electrode for IRE ablation of esophageal cancer.

SUMMARY OF THE INVENTION

The invention provides an invasive electrode for irreversible electroporation treatment of esophageal tumor tissue to solve the technical problems such as complicated operation of electrodes for treating esophageal cancer and poor wound healing in the prior art.

An invasive electrode for irreversible electroporation treatment of esophageal tumor tissue, comprising: a fixed shell, a sheath, an electrode sheath, an electrode wire and an electrode;

The fixed casing is provided with a pulling mechanism, and the pulling mechanism is arranged to be able to displace relative to the fixed casing,

The sheath is configured as a flexible sheath with a hollow cavity, one end of which is connected to the fixed shell and the other end is connected to the electrode sheath;

The electrode sheath has an accommodating cavity, and an electrode fixing ring is slidably arranged in the accommodating cavity, one end of the electrode fixing ring is connected to the electrode, and the other end abuts one end of an elastic element, and the elastic element is arranged on the in the accommodating cavity, the other end of which abuts the electrode sheath;

The electrode wire passes through the hollow cavity of the sheath and the accommodating cavity of the electrode sheath, one end of which is connected to the pulling mechanism, and the other end is connected to the electrode or the electrode fixing ring.

Preferably, the pulling mechanism is configured to be embedded in the fixed housing.

Preferably, the sheath and the electrode sheath are both metal sheaths.

Preferably, the outer layer of the sheath is sprayed with a Pefolin coating.

Preferably, the elastic element is configured as a compression spring.

Preferably, a fixed block is further provided in the accommodating cavity, and the other end of the elastic element abuts on the fixed block.

The invasive electrode for irreversible electroporation treatment of esophageal tumor tissue of the present invention can realize non-invasive, accurate and convenient irreversible electroporation electrode arrangement, greatly reduce the difficulty of operating instruments during treatment, and is very suitable for the treatment of esophageal cancer. It reduces the risk of surgery for the patient and facilitates the surgical treatment of the patient.

Description of drawings

In order to illustrate the embodiments of the present invention or the technical solutions in the prior art more clearly, the following briefly introduces the accompanying drawings that need to be used in the description of the embodiments or the prior art. Obviously, the drawings in the following description are For some embodiments of the present invention, for those of ordinary skill in the art, other drawings can also be obtained according to these drawings without creative effort.

FIG. 1 is a schematic structural diagram of an invasive electrode for irreversible electroporation treatment of esophageal tumor tissue according to the present invention.

Detailed ways

In order to make the purposes, technical solutions and advantages of the embodiments of the present invention clearer, the accompanying drawings in the embodiments of the present invention will be connected below, and the technical solutions in the embodiments of the present invention will be described clearly and completely. Obviously, the described embodiments These are some, but not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

As shown in FIG. 1 , an invasive electrode for irreversible electroporation treatment of esophageal tumor tissue of the present invention includes: a fixed casing 10 , a sheath 17 , an electrode sheath 15 , an electrode wire 18 and an electrode 11 ;

Wherein, the fixed casing 10 is arranged to be connected with the sheath 17, and a pulling mechanism 19 is arranged thereon, and the pulling mechanism 19 is arranged to be displaceable relative to the fixed casing 10,

The sheath 17 is configured as a flexible sheath with a hollow cavity, one end of which is connected to the fixed casing 10 and the other end is connected to the electrode sheath 15;

The electrode sheath 15 is connected to one end of the sheath 17, which has an accommodation cavity 15A, and an electrode fixing ring 12 is slidably arranged in the accommodation cavity 15A, and one end of the electrode fixing ring 12 is connected to the electrode 11, so the electrode 11 can follow The electrode fixing ring 12 slides into the accommodating cavity 15A. The electrode fixing ring 12 is connected to the electrode 11 to drive its displacement to ensure the smooth displacement of the electrode 11 (the electrode 11 may not move smoothly if the diameter of the electrode 11 is too small). The other end of the electrode fixing ring 12 Abutting one end of the elastic element 13, the elastic element 13 is disposed in the accommodating cavity 15A and the other end abuts against the electrode sheath 15. In this embodiment, the accommodating cavity 15A is also provided with a fixed stopper 14, and the other end of the elastic element 13 abuts against the electrode sheath 15. One end abuts on the fixing stopper 14 , so in the initial state, the elastic element 13 provides elastic force to the electrode fixing ring 12 , so that the electrode 11 can be forced out of the accommodating cavity 15A.

The electrode wire 18 passes through the hollow cavity of the sheath 17 and the electrode sheath 15, one end of which is connected to the pulling mechanism 19 and the other end is connected to the electrode 11 or the electrode fixing ring 12. In this embodiment, it is connected to the electrode 11 to ensure the force To the electrode 11, in this connection mode, the electrode fixing ring 12 is provided with a hollow part or a through hole for the electrode wire 18 to pass through. Therefore, when the pulling mechanism 19 is displaced, the electrode 11 can be moved by pulling the electrode wire 18 so that it can be retracted. Or protrude into the accommodating cavity 15A.

In this embodiment, the pulling mechanism 19 is arranged to be embedded in the fixed housing 10, which is convenient for operation.

In this embodiment, the sheath 17 and the electrode sheath 15 are both set as metal sheaths.

In this embodiment, the outer layer of the sheath 17 is sprayed with a Pyfrin coating 16 for insulation from human tissue.

In this embodiment, the elastic element 13 is configured as a compression spring.

When the invasive electrode of the present invention is used for irreversible electroporation treatment of esophageal tumor tissue, it is bound to the endoscope and follows the endoscope to the esophagus tumor target. When the endoscope enters the human body, the operator operates The pulling mechanism 19 shrinks the electrode 11 into the accommodating space 15A of the electrode sheath 15 to prevent the electrode from damaging human tissue. When the endoscope reaches the target position of the tumor tissue, the operator operates the pulling mechanism 19, and the electrode 11 is extended from the accommodation space 15A by the force of the elastic element 13 for treatment, and after the treatment is completed, the pulling mechanism is operated again. 19 The electrode 11 is retracted back into the accommodation space 15A, and the entire device is then taken out.

The invention solves the requirement of flexibly and accurately constructing the required electric field during non-invasive treatment of esophageal tumor tissue by irreversible electroporation, and proposes a portable and operable invasive electrode implementation scheme, which can follow the endoscope to reach the target patient area, Accurately adjust the electrode placement position and insertion depth to achieve a good therapeutic effect.

As mentioned above, an invasive electrode for irreversible electroporation treatment of esophageal tumor tissue of the present invention can realize non-invasive, accurate and convenient irreversible electroporation electrode arrangement, greatly reduce the difficulty of operating instruments during treatment, and is very suitable for use in esophagus. The treatment of cancer greatly reduces the risk of surgery for patients and helps patients with surgical treatment.

Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, but not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that: It can still carry out the technical solutions recorded in the foregoing embodiments, or perform equivalent replacements on some of the technical features thereof, and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and spirit of the technical solutions in the embodiments of the present invention. scope.

Claims (6)

1. an invasive electrode for irreversible electroporation treatment of esophageal tumor tissue, characterized in that, comprising: a fixed casing, a sheath, an electrode sheath, an electrode wire and an electrode; The fixed casing is provided with a pulling mechanism, and the pulling mechanism is arranged to be able to displace relative to the fixed casing, The sheath is configured as a flexible sheath with a hollow cavity, one end of which is connected to the fixed shell and the other end is connected to the electrode sheath; The electrode sheath has an accommodating cavity, and an electrode fixing ring is slidably arranged in the accommodating cavity, one end of the electrode fixing ring is connected to the electrode, and the other end abuts one end of an elastic element, and the elastic element is provided in the accommodating cavity, the other end of which is abutted against the electrode sheath; The electrode wire passes through the hollow cavity of the sheath and the accommodating cavity of the electrode sheath, one end of which is connected to the pulling mechanism, and the other end is connected to the electrode or the electrode fixing ring. 2 . The invasive electrode for irreversible electroporation treatment of esophageal tumor tissue according to claim 1 , wherein the pulling mechanism is configured to be embedded in the fixed housing. 3 . 3 . The invasive electrode for irreversible electroporation treatment of esophageal tumor tissue according to claim 2 , wherein the sheath and the electrode sheath are both set as metal sheaths. 4 . 4 . The invasive electrode for irreversible electroporation treatment of esophageal tumor tissue according to claim 3 , wherein the outer layer of the sheath is sprayed with a Pyfrin coating. 5 . 5 . The invasive electrode for irreversible electroporation treatment of esophageal tumor tissue according to claim 4 , wherein the elastic element is configured as a compression spring. 6 . 6 . The invasive electrode for irreversible electroporation treatment of esophageal tumor tissue according to any one of claims 1 to 5 , wherein a fixed stop is further provided in the accommodating cavity, and the elastic element has a fixed stopper. The other end abuts on the fixed stopper.

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