CN111698982B

CN111698982B - Hair treatment composition

Info

Publication number: CN111698982B
Application number: CN201980012081.8A
Authority: CN
Inventors: 萩原基文; 景山亚美; 江浜律子
Original assignee: Shiseido Co Ltd
Current assignee: Shiseido Co Ltd
Priority date: 2018-02-09
Filing date: 2019-01-30
Publication date: 2024-09-27
Anticipated expiration: 2039-01-30
Also published as: CN111698982A; TW201940155A; WO2019155968A1; JPWO2019155968A1

Abstract

The present invention provides a hair treatment composition for thickening hair and/or repairing the surface of hair. The present invention provides a hair treatment composition for thickening hair and/or repairing the surface of hair, which comprises a cationic active agent and/or glyoxylate as an active ingredient. Furthermore, the present invention also provides a method for thickening hair and/or repairing the surface of hair comprising the step of applying such a composition to the hair.

Description

Hair treatment composition

Technical Field

The present invention relates to a hair treatment composition. More specifically, the present invention relates to a hair treatment composition for thickening hair and/or repairing the surface of hair.

Background

The individuals who have the trouble of thin hair and not full hair due to various factors such as genetic factors, age increase, and changes in hormone amount. Therefore, there is a demand for hair that the entire hair is enhanced to be full by thickening the hair by hair.

For the purpose of thickening hair, a hair treatment agent containing a protein as an active ingredient has been proposed (patent document 1). However, this hair treatment agent is composed of a combination of two agents, i.e., a reducing agent and an oxidizing agent, and is time-consuming and labor-consuming to treat hair. Further, a resin composition for making hair look thick is disclosed (patent document 2), but it is required to be applied every time when the hair is washed off. Further, in order to increase the thickness of hair, a hair treatment agent containing a multi-chain, multi-hydrophilic-based compound such as an anionic surfactant is disclosed (patent document 3). However, anionic surfactants have a disadvantage that they damage hair due to removal of lipid and protein from hair (patent documents 4 and 5). In this case, there is a need for a novel composition and method which do not have the above-mentioned drawbacks and have a high effect of thickening hair and/or repairing the surface of hair.

Prior art literature

Patent literature

Patent document 1: japanese patent laid-open No. 2007-91739

Patent document 2: japanese patent No. 4812958

Patent document 3: japanese patent laid-open No. 2006-56874

Patent document 4: japanese patent laid-open No. 2007-153779

Patent document 5: japanese patent laid-open No. 2007-217433

Patent document 6: japanese patent No. 5947340

Patent document 7: japanese patent No. 6122942

Disclosure of Invention

Problems to be solved by the invention

The present invention addresses the problem of providing a hair treatment composition for thickening hair and/or repairing the surface of hair.

The present inventors have conducted intensive studies on the effects of various components on thickening hair and/or repairing the surface of hair, and as a result, have found for the first time that a cationic surfactant and glyoxylate have particularly high effects, and have completed the present application.

Specifically, the present invention relates to the following inventions:

(1) A composition for thickening hair and/or repairing hair surface,

Which contains a cationic active agent and/or glyoxylate as an active ingredient.

(2) The composition according to (1), wherein the cationic active agent is an ammonium salt represented by the following formula (I).

(Wherein R ¹、R²、R³ and R ⁴ may be the same or different, and at least 1 of them represents a linear or branched alkyl or alkenyl group having 8 to 18 carbon atoms, or R ⁵-O-R⁶ - (wherein R ⁵ represents a linear or branched alkyl or alkenyl group having 8 to 18 carbon atoms, R ⁶ represents an ethylene group or a propylene group), the remainder represents a hydrogen atom or represents an alkyl or benzyl group having 1 to 3 carbon atoms which may have a hydroxyl group as a substituent, and X ^- represents an anion)

(3) The composition according to (2), wherein the ammonium salt is a quaternary ammonium salt represented by the following formula (II).

(Wherein R ¹、R²、R³ and R ⁴ may be the same or different, at least 1 of them represents a linear or branched alkyl or alkenyl group having 8 to 18 carbon atoms, the remainder represent an alkyl or benzyl group having 1 to 3 carbon atoms which may have a hydroxyl group as a substituent, and X ^- represents an anion)

(4) The composition according to (3), wherein the quaternary ammonium salt is 1 or more selected from the group consisting of octyl trimethyl ammonium chloride, decyl trimethyl ammonium chloride, lauryl trimethyl ammonium chloride, myristyl trimethyl ammonium chloride, cetyl trimethyl ammonium chloride, stearyl trimethyl ammonium chloride, and dilauryl dimethyl ammonium chloride.

(5) The composition according to any one of (1) to (4), wherein the amount of the cationic active agent is 0.01 to 5% by weight.

(6) The composition according to (1), wherein the amount of glyoxylic acid is 1 to 25% by weight.

(7) The composition according to any one of (1) to (6), wherein the pH of the composition is in the range of 2 to 9.

(8) The composition according to any one of (1) to (7), which is applied to hair for 1 minute to 1 week.

(9) The composition according to any one of (1) to (8), wherein the hair is heated after the composition is applied to the hair.

(10) The composition according to (9), wherein the heating temperature is 150℃or higher.

(11) A method for cosmetic or therapeutic treatment of thickening and/or repairing the surface of hair,

Comprising the step of applying the composition of any one of (1) to (10) to hair.

(12) The method according to (11), further comprising the step of heating the hair after the composition is applied to the hair.

(13) The method according to (12), wherein the heating temperature is 150℃or higher.

ADVANTAGEOUS EFFECTS OF INVENTION

The composition of the present invention comprising a cationic active and/or glyoxylic acid can thicken hair and/or repair the surface of hair.

Drawings

Fig. 1 shows an example of hair having a smooth cross-sectional shape.

Fig. 2 shows an example of hair with smooth hair surface.

Fig. 3 shows an example of hair in which irregularities are formed in the cross-sectional shape of hair.

Fig. 4 shows an example of hair in which irregularities are formed on the surface of the hair.

Fig. 5 shows the hair diameter increasing effect of each active agent. * Indicating significant differences (< p < 0.05, < p < 0.001) by Student's t-test relative to the control without active agent.

Fig. 6 shows the effect of increasing hair diameter due to the difference in the types of cationic active agents. * Indicating significant differences (< p < 0.05, < p < 0.001) by Student's t-test relative to the control without active agent.

Fig. 7 shows the effect of increasing the hair diameter due to the difference in carbon chain length of the cationic active agent. * Indicating significant differences (< p < 0.05, < p < 0.001) by Student's t-test relative to the control without active agent.

FIG. 8 shows the effect of increasing hair diameter due to the difference in pH of the LTC composition.

Fig. 9 shows the effect of increasing hair diameter due to the difference in LTC concentration.

FIG. 10 shows the effect of increasing hair diameter due to the difference in the impregnation time of the LTC composition.

Fig. 11 shows the effect of increasing the capillary diameter of glyoxylic acid. * Indicating a significant difference (< 0.001) by Student's t-test relative to the control containing no glyoxylic acid.

Detailed Description

The present inventors have conducted intensive studies to find a component for thickening hair, and as a result, have found that the effect of a cationic active agent and glyoxylic acid is particularly high. The composition of the present application containing a cationic active agent and/or glyoxylate as an active ingredient can swell hair from inside and increase hair diameter. By thickening the hair, the elasticity and toughness of the hair can be improved, and the overall fullness of the hair can be increased.

Further, the present inventors have found that the unevenness of the cross-sectional shape of hair is related to the feel of the hair. The present inventors have found that healthy hair has a smooth cross-sectional shape and a smooth surface, for example, as shown in fig. 1 and 2, and thus has a good touch, whereas if the hair has a rough cross-sectional shape and a rough surface, as shown in fig. 3 and 4, the hair is lost to be dry and the touch is deteriorated. The inventors of the present application have found that, for healthy hair, for example, as shown in fig. 2, light is reflected without being scattered, and thus good gloss is exhibited, but if the cross-sectional shape is not smooth and has irregularities on the surface, light is scattered as shown in fig. 4, and thus gloss is poor. However, the composition of the present application containing a cationic active agent and/or glyoxylate as an active ingredient can repair the surface of hair by swelling the hair from the inside. By repairing the surface of the hair, the smoothness and luster of the hair can be improved, and the dryness can be reduced.

The term "thickening hair" as used herein means increasing the thickness of hair by hair. For example, the diameter of the hair in the cross-sectional view shown in fig. 1 is increased. The diameter (Mao Jing) of the hair can be measured by a microscope after fixing the hair so that the observation angle before and after application of the composition becomes constant, for example, as described in the examples. For example, the effect of the composition of the present application to coarsen the hair diameter is determined by measuring the hair diameter before and after the application of the composition of the present application, and if the hair diameter after the application is increased by, for example, 0.1% or more, 0.2% or more, 0.3% or more, 0.4% or more, 0.5% or more, 1% or more, 2% or more, 3% or more, 4% or more, 5% or more, 6% or more, 7% or more, 8% or more, 9% or more, or 10% or more as compared with the hair diameter before the application, the composition of the present application is judged to have the effect of coarsen the hair diameter. In the present application, the term "thickening hair" may also mean that the cross-sectional area of hair in a cross-sectional view such as shown in fig. 1 and 3 is increased, for example.

In the present invention, the term "repairing the surface of hair" means, for example, smoothing the irregularities or unevenness of the surface of hair as shown in fig. 3 and 4. For example, the surface state shown in fig. 1 and 2 may be used, but the degree of restoration of the roughness or unevenness of the hair surface is not necessarily limited.

The cationic active agent of the present invention means a surfactant exhibiting cationic properties. The surfactant is a generic term for substances having a hydrophilic group and a hydrophobic group. Among the surfactants, anionic, cationic, amphoteric and nonionic surfactants (cationic surfactants) are often used in rinse-off conditioners (HAIR RINSE) and hair conditioners (conditioners) for imparting softness to hair (patent documents 4 and 5). However, the cationic active agent is not known to have an effect of thickening hair and an effect of repairing unevenness of the cross-sectional shape of hair.

Particularly preferred cationic active agents are ammonium salts represented by the following formula (I).

For example, as the cationic active agent of the present invention, a quaternary ammonium salt represented by the following formula (II) can be preferably used.

Examples of the quaternary ammonium salt of the formula (II) include combinations of one or more of the group consisting of octyltrimethylammonium chloride, octyltrimethylammonium bromide, decyltrimethylammonium chloride, decyltrimethylammonium bromide, lauryltrimethylammonium chloride, lauryltrimethylammonium bromide, myristyltrimethylammonium chloride, myristyltrimethylammonium bromide, cetyltrimethylammonium chloride, cetyltrimethylammonium bromide, stearyltrimethylammonium chloride, stearyltrimethylammonium bromide, beyltrimethylammonium chloride, beyltrimethylammonium bromide, lauryldimethylbenzyl ammonium chloride, myristyldimethylbenzyl ammonium chloride, cetyldimethylbenzyl ammonium chloride, stearyl dimethylbenzyl ammonium chloride, and ditolyl dimethyl ammonium chloride such as dilauryldi dimethyl ammonium chloride, dimyristol dimethyl ammonium chloride, dimetyl dimethyl ammonium chloride, and distearyldimethyl ammonium chloride.

Further, the cationic active agent preferable in the present invention is sometimes a combination of 1 or more selected from octyl trimethyl ammonium chloride, decyl trimethyl ammonium chloride, lauryl trimethyl ammonium chloride, myristyl trimethyl ammonium chloride, cetyl trimethyl ammonium chloride, stearyl trimethyl ammonium chloride, dilauryldimethyl ammonium chloride, and dimyristoyl dimethyl ammonium chloride, and particularly preferable is lauryl trimethyl ammonium chloride and myristyl trimethyl ammonium chloride alone or a combination of both.

Further, as the cationic active agent of the present invention, for example, a tertiary ammonium salt represented by the following formula (III) may be preferably used.

(Wherein R ¹、R² and R ³ may be the same or different, at least 1 of them represents a linear or branched alkyl or alkenyl group having 8 to 18 carbon atoms, the remainder represent an alkyl or benzyl group having 1 to 3 carbon atoms which may have a hydroxyl group as a substituent, and X ^- represents an anion)

Examples of the tertiary ammonium salt of the formula (III) include octyl dimethyl ammonium chloride, octyl dimethyl ammonium bromide, decyl dimethyl ammonium chloride, decyl dimethyl ammonium bromide, lauryl dimethyl ammonium chloride, lauryl dimethyl ammonium bromide, myristyl dimethyl ammonium chloride, myristyl dimethyl ammonium bromide, cetyl dimethyl ammonium chloride, cetyl dimethyl ammonium bromide, stearyl dimethyl ammonium chloride, stearyl dimethyl ammonium bromide, behenyl dimethyl ammonium chloride, behenyl dimethyl ammonium bromide, lauryl methyl benzyl ammonium chloride, myristyl methyl benzyl ammonium chloride, cetyl methyl benzyl ammonium chloride, stearyl methyl benzyl ammonium chloride, and dicarballyl methyl ammonium chloride such as dilaurylmethyl ammonium chloride, dimyristylmethyl ammonium chloride, and distearyl methyl ammonium chloride.

In addition, as the cationic active agent of the present invention, for example, a quaternary ammonium salt represented by the following formula (IV) can be preferably used.

(Wherein R ²、R³ and R ⁴ each represent an alkyl group having 1 to 3 carbon atoms which may have a hydroxyl group as a substituent, or a benzyl group which may be the same or different, R ⁵ each represents an alkyl group having 8 to 18 carbon atoms, or an alkenyl group, R ⁶ each represents an ethylene group or a propylene group, and X ^- each represents an anion)

Examples of the quaternary ammonium salt of formula (IV) include octyl ethyl trimethyl ammonium chloride, octyl propyl trimethyl ammonium chloride, octyl ethyl trimethyl ammonium bromide, octyl propyl trimethyl ammonium bromide, decyl ethyl trimethyl ammonium chloride, decyl propyl trimethyl ammonium chloride, decyl ethyl trimethyl ammonium bromide, decyl propyl trimethyl ammonium bromide, lauryl ethyl trimethyl ammonium chloride, lauryl ethyl trimethyl ammonium bromide, lauryl propyl trimethyl ammonium bromide, myristyl ethyl trimethyl ammonium chloride, myristyl propyl trimethyl ammonium chloride, myristyl ethyl trimethyl ammonium bromide, myristyl propyl trimethyl ammonium bromide, cetyl ethyl trimethyl ammonium chloride, cetyl propyl trimethyl ammonium chloride, cetyl ethyl trimethyl ammonium bromide, stearyl ethyl trimethyl ammonium chloride, stearyl propyl trimethyl ammonium chloride, stearyl ethyl trimethyl ammonium bromide, and stearyl propyl trimethyl ammonium bromide.

Further, as the cationic active agent of the present invention, for example, a tertiary ammonium salt represented by the following formula (V) may be preferably used.

(Wherein R ² and R ³ each represent an alkyl group having 1 to 3 carbon atoms which may have a hydroxyl group as a substituent, or a benzyl group which may be the same or different, R ⁵ each represents an alkyl group having 8 to 18 carbon atoms, or an alkenyl group, R ⁶ each represents an ethylene group or a propylene group, and X ^- each represents an anion)

Examples of the tertiary ammonium salt of the formula (V) include octyl ethyl dimethyl ammonium chloride, octyl propyl dimethyl ammonium chloride, octyl ethyl dimethyl ammonium bromide, octyl propyl dimethyl ammonium bromide, decyl ethyl dimethyl ammonium chloride, decyl propyl dimethyl ammonium chloride, decyl ethyl dimethyl ammonium bromide, decyl propyl dimethyl ammonium bromide, lauryl ethyl dimethyl ammonium chloride, lauryl ethyl dimethyl ammonium bromide, lauryl propyl dimethyl ammonium bromide, myristyl ethyl dimethyl ammonium chloride, myristyl propyl dimethyl ammonium chloride, myristyl ethyl dimethyl ammonium bromide, myristyl propyl dimethyl ammonium bromide, cetyl ethyl dimethyl ammonium chloride, cetyl propyl dimethyl ammonium chloride, cetyl ethyl dimethyl ammonium bromide, cetyl ethyl dimethyl ammonium chloride, stearyl propyl dimethyl ammonium chloride, stearyl ethyl dimethyl ammonium bromide, stearyl propyl dimethyl ammonium bromide, and stearyl propyl dimethyl ammonium bromide.

The number of carbon atoms of the linear or branched alkyl or alkenyl group in the above-mentioned formulae (I) to (V) is preferably 8 to 18, more preferably 12 to 14.

The anions represented by X ^- in the above formulas (I) to (V) are not particularly limited as long as they are anions capable of forming salts with ammonium, such as halogen atoms such as chlorine and bromine, and organic acids such as alkyl sulfuric acid having 1 to 3 carbon atoms.

Glyoxylic acid is a carboxylic acid represented by H-CO-COOH. Glyoxylate is used for permanent waving agents, hair straightening agents, and the like (patent documents 6 and 7). However, glyoxylic acid is not known to have an effect of thickening the hair diameter and an effect of repairing the hair surface.

The active ingredient in the composition of the present invention is preferably contained in such a concentration that the effect of thickening hair and/or repairing the surface of hair is sufficiently exhibited.

The concentration of the cationic active agent in the composition of the present invention is preferably 0.01 to 5 wt%, more preferably 0.05 to 1 wt%, particularly preferably 0.1 to 0.5 wt%, based on the total amount of the composition of the present invention. The effect of increasing the diameter of the bristles is higher as the concentration is higher, but a sufficient effect can be confirmed at 0.1 wt%, and if the concentration exceeds 0.5 wt%, an effect corresponding to the amount of the bristles cannot be expected even if the amount exceeds the amount.

The concentration of glyoxylate in the composition of the invention is preferably 1 to 25% by weight, more preferably 5 to 20% by weight, particularly preferably 10 to 15% by weight, based on the total amount of the composition of the invention.

The pH of the composition of the present invention containing the cationic active agent as an active ingredient is preferably 2 to 9,3 to 9, 4 to 9, 5 to 9, 6 to 9, or 7 to 9. Also, pH2 to 8, pH3 to 8, pH4 to 8, pH5 to 8, pH6 to 8, and pH7 to 8 are preferable. Also, pH2 to 7, pH3 to 7, pH4 to 7, pH5 to 7, and pH6 to 7 are preferable. When the pH is in the range of 3 to 7, the effect of increasing the hair diameter increases as the pH increases, and the effect becomes almost constant when the pH is 7 or more. However, even at pH3, a significant effect was confirmed. If the pH is too high, the alkalinity becomes high, which causes damage to the scalp and hair.

The pH of the composition of the present invention containing glyoxylic acid as an active ingredient is preferably 2 to 9, 3 to 8, 4 to 7, 5 to 9, 6 to 8 or 7. Also, pH2 to 8, pH3 to 8, pH2 to 7, pH3 to 7, pH2 to 6, pH3 to 6, pH2 to 5, pH3 to 5, pH2 to 4, and pH3 to 4 are preferable in some cases.

The time for applying the composition of the present invention to hair is preferably, for example, 1 minute to 1 week, 1 minute to 120 hours, 3 minutes to 1 week, 3 minutes to 120 hours, 3 minutes to 96 hours, 5 minutes to 1 week, 5 minutes to 120 hours, 5 minutes to 96 hours, 5 minutes to 72 hours, 15 minutes to 24 hours, 1 hour to 6 hours, 2 hours to 6 hours, or the like. The effect of increasing the hair diameter increases as the application time increases, but a sufficient effect can be confirmed even in 5 minutes, and the effect becomes almost constant if it is 6 hours or longer.

The method of applying the composition of the present invention is not particularly limited, but is preferably applied by a method that sufficiently exerts the effect of thickening hair and/or repairing the surface of hair. It is particularly preferred that the compositions of the present invention are applied directly to the hair.

The composition of the present invention can be applied to hair, and for example, rinse-off hair conditioner, hair cream, hair mask, hair cream, mousse, shampoo, hair tonic, emulsion, lotion, aerosol, hair waving agent, hair straightening agent, and the like can be used, but is not limited thereto.

The composition of the present invention containing a cationic active agent as an active ingredient can be applied, for example, in the form of a rinse-off conditioner or a cream, for example, 1 week, 1 time 3 days, 1 time 2 days, 1 time 1 day, 2 times 1 day, 3 times 1 day, and a proper amount of, for example, 1 to 10m, 1 to 5ml, etc., to the hair after shampooing.

The composition of the present invention containing glyoxylic acid as an active ingredient can be applied, for example, in the form of a hair cream, for example, 6 months 1,5 months 1, 4 months 1,3 months 1,2 months 1, 1 month 2, 1 month 3, 1 month 4, and the like to hair in an appropriate amount of, for example, 10ml to 200ml, 50ml to 100ml, and the like.

In addition, it is preferable that the composition of the present invention containing glyoxylate as an active ingredient is impregnated into hair and then the hair is subjected to a heat treatment. The heating temperature is also preferably 150℃to 300℃and 160℃to 280℃and 170℃to 250℃and 180℃to 230℃and more preferably 180℃to 230 ℃. And also more preferably 150℃to 230 ℃.

The heating time is preferably, for example, 1 second to 10 minutes, 2 seconds to 10 minutes, 3 seconds to 10 minutes, 4 seconds to 10 minutes, 5 seconds to 10 minutes, 10 seconds to 5 minutes, 20 seconds to 3 minutes, 30 seconds to 2 minutes, 1 minute to 2 minutes, 30 seconds to 1 minute, or the like.

However, the concentration of the active ingredient in the composition, the pH of the composition, the dipping time, the morphology, the application method, the application amount, the heating temperature, the heating time may be appropriately adjusted according to the hair quality, the thickness, the amount, the number of roots, the state of the scalp, the room temperature, etc., of the subject, and are not limited to the above-mentioned morphology.

The composition of the present application may contain, if necessary and as long as the effect of the present application is not impaired, various oily or aqueous components, moisturizers, thickeners, preservatives, antioxidants, fragrances, colorants, various drugs, etc. which are generally used in hair treatment compositions, hair cosmetics, quasi-drugs, medicines, etc.

Further, the present application also provides a method for thickening hair and/or repairing the surface of hair comprising the step of applying the composition of the present application to hair.

In the method for thickening hair and/or repairing the surface of hair of the present invention, for example, the hair can be thickened and/or the surface of hair can be repaired by applying a composition comprising 0.1 to 0.5 wt% of lauryl trimethyl ammonium chloride and having a pH of 3 to 8 to the hair for 5 minutes to 1 week.

In the method for thickening hair and/or repairing the surface of hair of the present invention, for example, a composition having a pH of 2 to 7 containing 10 to 15 wt% of glyoxylate may be applied to hair for 5 minutes to 1 week, and then the hair may be heated at 150 to 230 ℃ for 30 seconds to 2 minutes to thicken the hair and/or repair the surface of the hair.

Examples

The present invention will be described in further detail by examples. The present invention is not limited to this.

Experiment 1: the effect of the various active agents to increase the hair diameter was verified by using the various active agents shown below.

TABLE 1

Measurement of hair diameter

The hair diameter was measured by using a microscope (VHX 1000: kexin). In order to compare the roughness of the same portion at the same angle before and after the treatment, the hair tape was attached to the petri dish, and the roughness of the hair at the portion exposed from the tape by 0.1mm was measured before and after the treatment and compared.

Hair was used in which healthy hair of a person purchased by the tibetan society was treated 4 times with a hair dye and a hair waving agent. Treatment with hair dye was performed by mixing 1 dose (PRIMIENCE N) with 2 doses (PRIMIENCE) to give 1 dose: 2 doses = 1:1 and treated at 31 c for 30 minutes. Treatment with the permanent wave agent was carried out by treating 1 dose (CRYSTARIZING STRAIGHT H, STRAIGHTNER) at 31℃for 15 minutes, and then treating 2 doses (CRYSTARIZING STRAIGHT, 2, neutralizing Emulsion) at 31℃for 3 minutes.

Preparation of solution

Solutions each containing the active agents described in table 1 were prepared with the compositions shown in table 2 below. In addition, a solution prepared in the same manner without the active agent was used as a control.

TABLE 2

The hair was immersed in the solution prepared in the above manner for 1 hour, washed with water, dried, and then the hair diameter was measured by the above method. The statistical significance difference test used Student's t-test (< 0.05, < 0.01, < 0.001).

The results are shown in fig. 5. As is clear from fig. 5, LTC and STC as cationic active agents have a higher effect of thickening hair diameters than the control. The effect of LTC is particularly high. On the other hand, the hair diameter of the treated amphoteric active agent such as LES, AMT, etc., the amphoteric active agent such as IMB, AMPB, etc., was not significantly changed from that of the control, and the effect of thickening the hair diameter or the effect of thickening the hair diameter was not very low.

Experiment 2: effect of thickening hair diameter caused by cationic active agents

Next, the effect of using each cationic active agent to make the hair diameter larger was examined. The experiment was performed by the same composition and method as in experiment 1 except that the active agent used was the one shown in table 3 below, and the concentration thereof was 0.5%. The statistical significance difference test used Student's t-test (< 0.05, < 0.01, < 0.001).

TABLE 3

The results are shown in fig. 6. As can be seen from fig. 6, the effect of increasing the hair diameter of LTC with a carbon chain of 12 is very high. However, STC with carbon chain 18, DLTC with chain 2 of LTC also had a significant hair diameter increasing effect compared to the control.

Experiment 3: effect of thickening hair diameter caused by different carbon chains of cationic active agent

Next, the effect of thickening the hair diameter by using a cationic active agent having each carbon chain length was studied. The cationic active agent used in the experiment was the same composition and method as in experiment 1 except that the cationic active agent was immersed in the solution having a concentration of 10 wt% for 6 hours as shown in table 4 below. The statistical significance difference test used Student's t-test (< 0.05, < 0.01, < 0.001).

TABLE 4

The results are shown in fig. 7. As can be seen from fig. 7, all of the cationic active agents used in experiment 3 significantly increased the hair diameter relative to the control. It is found that the effect of swelling the hair diameter is particularly high, and that the cationic active agent having a carbon chain of 12 to 14 has a hair diameter increasing effect even when the cationic active agent having another carbon length is used.

Experiment 4: effect of thickening hair diameter of LTC due to pH difference

The difference in the effect of increasing hair diameter by pH was investigated using LTC. In the experiment, the same composition/method as in experiment 1 was performed except that 5wt% LTC was used as the cationic active agent, and the pH of each composition was adjusted to 2,3, 4,5, 6, and 7 using sodium hydroxide.

The results are shown in fig. 8. As is clear from fig. 8, the effect of swelling the hair diameter is high when the pH of the composition is high at pH3 to 7, but the effect of increasing the hair diameter is high in all pH values as compared with the control. The above experiments were also performed at pH8 and 9, and as a result, it was found that the same results as in the case of pH7 (not shown) were obtained, and that even when the pH was excessively high at a pH of 7 or more, the hair growth effect was not changed much.

Experiment 5: concentration study

The difference in the effect of increasing hair diameter due to the concentration of LTC was examined. In the experiment, the same composition and method as in experiment 1 were performed except that LTC was used as the cationic active agent, and the LTC concentration of each composition was adjusted to 0.0 wt%, 0.1 wt%, 0.5 wt%, 1.0 wt%, 5.0 wt%.

The results are shown in fig. 9. At an LTC concentration of 0.1 wt.% of the composition, the hair diameter showed an increase of more than 5%. When the amount is 0.5% by weight or more, the hair diameter increasing effect becomes almost constant.

Experiment 6: study of the immersion time

The difference in the effect of increasing the hair diameter due to the dipping time of the LTC solution was examined. In the experiment, the same composition/method as in experiment 1 was performed except that 0.5 wt% LTC was used as the cationic active agent, and the time for immersing the hair in the solution was 5 minutes, 15 minutes, 1 hour, 2 hours, 6 hours, and 24 hours.

The results are shown in fig. 10. According to fig. 10, the hair diameter showed an increase of about 2 to 3% at an immersion time of 5 minutes. The effect of increasing the diameter of the bristles increases as the immersion time increases, but becomes almost constant if the immersion time is 6 hours or longer.

Experiment 7: changes in hair diameter caused by glyoxylate treatment

Hair obtained by the same method as in experiment 1 was used. Solutions having the compositions shown in table 5 were prepared. The pH of the solution was about 2. As a control, phosphate buffer containing no glyoxylic acid was used. The hair was immersed in the thus prepared solution for 1 hour. After dipping, the hair was dried by a dry hair cap and treated with a hair iron at 180 ℃ for 60 seconds. After the treatment, the hair was washed with shampoo and dried. The diameter of the dried hair was measured by the same method as described above. The statistical significance difference test used Student's t-test (< 0.05, < 0.01, < 0.001).

TABLE 5

The results are shown in fig. 11. It was found that the hair diameter was significantly increased compared to the control solution containing no glyoxylic acid in the buffer only. Therefore, the effect of increasing the capillary diameter of glyoxylic acid was confirmed.

In these examples, hair damaged by the treatment with the hair dye and the hair waving agent was used, but even when the composition of the present invention was applied to healthy hair, the hair diameter was increased by a statistically significant difference before and after the treatment, and the same effect of increasing the hair diameter was confirmed.

Industrial applicability

If the compositions, methods of the present invention are used, the hair may be thickened and/or the surface of the hair may be repaired. The hair can be thickened to increase the overall fullness of the hair, and the hair can be restored to its surface to improve smoothness and luster and reduce dryness.

Claims

1. Use of a cationic active agent selected from the group consisting of 1 or more of octyltrimethylammonium chloride, decyltrimethylammonium chloride, lauryltrimethylammonium chloride, myristyltrimethylammonium chloride, cetyltrimethylammonium chloride, stearyltrimethylammonium chloride and dilauryldimethylammonium chloride for the manufacture of a medicament for thickening hair diameters.

2. The use according to claim 1, wherein the cationic active agent is present in an amount of 0.01 to 5% by weight.

3. Use according to claim 1 or 2, wherein the pH of the medicament is in the range of 2 to 9.

4. The use according to claim 1 or 2, wherein the medicament is applied to the hair for 1 minute to 1 week.