CN111643718A - Hydrocolloid dressing glue with self-bacterium-inhibiting effect and preparation method thereof - Google Patents
Hydrocolloid dressing glue with self-bacterium-inhibiting effect and preparation method thereof Download PDFInfo
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- CN111643718A CN111643718A CN202010533072.8A CN202010533072A CN111643718A CN 111643718 A CN111643718 A CN 111643718A CN 202010533072 A CN202010533072 A CN 202010533072A CN 111643718 A CN111643718 A CN 111643718A
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- 239000003292 glue Substances 0.000 title claims abstract description 34
- 239000000416 hydrocolloid Substances 0.000 title claims abstract description 26
- 230000002401 inhibitory effect Effects 0.000 title claims abstract description 14
- 238000002360 preparation method Methods 0.000 title abstract description 6
- 229920000642 polymer Polymers 0.000 claims abstract description 49
- 229920002678 cellulose Polymers 0.000 claims abstract description 34
- 239000001913 cellulose Substances 0.000 claims abstract description 34
- 229920001971 elastomer Polymers 0.000 claims abstract description 29
- 229920005989 resin Polymers 0.000 claims abstract description 27
- 239000011347 resin Substances 0.000 claims abstract description 27
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 20
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 20
- 229920001661 Chitosan Polymers 0.000 claims abstract description 16
- 239000000022 bacteriostatic agent Substances 0.000 claims abstract description 16
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims abstract description 16
- 239000000806 elastomer Substances 0.000 claims abstract description 15
- 229920003002 synthetic resin Polymers 0.000 claims abstract description 15
- 239000000057 synthetic resin Substances 0.000 claims abstract description 15
- 239000005060 rubber Substances 0.000 claims abstract description 14
- 239000004014 plasticizer Substances 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 12
- 230000000694 effects Effects 0.000 claims abstract description 7
- 238000003756 stirring Methods 0.000 claims abstract description 7
- 238000000034 method Methods 0.000 claims description 9
- 238000002791 soaking Methods 0.000 claims description 6
- KXGFMDJXCMQABM-UHFFFAOYSA-N 2-methoxy-6-methylphenol Chemical compound [CH]OC1=CC=CC([CH])=C1O KXGFMDJXCMQABM-UHFFFAOYSA-N 0.000 claims description 3
- VSKJLJHPAFKHBX-UHFFFAOYSA-N 2-methylbuta-1,3-diene;styrene Chemical compound CC(=C)C=C.C=CC1=CC=CC=C1.C=CC1=CC=CC=C1 VSKJLJHPAFKHBX-UHFFFAOYSA-N 0.000 claims description 3
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 claims description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 3
- 229920000896 Ethulose Polymers 0.000 claims description 3
- 239000001856 Ethyl cellulose Substances 0.000 claims description 3
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 3
- 239000001859 Ethyl hydroxyethyl cellulose Substances 0.000 claims description 3
- 229920000181 Ethylene propylene rubber Polymers 0.000 claims description 3
- 239000005662 Paraffin oil Substances 0.000 claims description 3
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 3
- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 claims description 3
- 150000004982 aromatic amines Chemical class 0.000 claims description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 3
- 229920003090 carboxymethyl hydroxyethyl cellulose Polymers 0.000 claims description 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 3
- 229920001249 ethyl cellulose Polymers 0.000 claims description 3
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 3
- 235000019326 ethyl hydroxyethyl cellulose Nutrition 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 239000002480 mineral oil Substances 0.000 claims description 3
- 235000010446 mineral oil Nutrition 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 239000003921 oil Substances 0.000 claims description 3
- 239000003208 petroleum Substances 0.000 claims description 3
- 229920001568 phenolic resin Polymers 0.000 claims description 3
- 239000005011 phenolic resin Substances 0.000 claims description 3
- 229920000058 polyacrylate Polymers 0.000 claims description 3
- 229920002857 polybutadiene Polymers 0.000 claims description 3
- 229920000098 polyolefin Polymers 0.000 claims description 3
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 229920003048 styrene butadiene rubber Polymers 0.000 claims description 3
- 150000003505 terpenes Chemical class 0.000 claims description 3
- 235000007586 terpenes Nutrition 0.000 claims description 3
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 2
- 238000000227 grinding Methods 0.000 claims description 2
- 239000007788 liquid Substances 0.000 abstract description 10
- 238000010521 absorption reaction Methods 0.000 abstract description 8
- 238000004898 kneading Methods 0.000 abstract 2
- 206010052428 Wound Diseases 0.000 description 7
- 208000027418 Wounds and injury Diseases 0.000 description 7
- 210000000416 exudates and transudate Anatomy 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 239000000463 material Substances 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 238000009395 breeding Methods 0.000 description 2
- 230000001488 breeding effect Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 239000002861 polymer material Substances 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010048038 Wound infection Diseases 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000005213 imbibition Methods 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 230000037314 wound repair Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B15/00—Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention relates to hydrocolloid dressing glue with a self-antibacterial effect and a preparation method thereof, wherein the hydrocolloid dressing glue comprises the following steps: (1) preparing raw materials, wherein the raw materials comprise the following raw materials in percentage by mass: 15-40% of rubber elastomer, 10-30% of tackifying resin, 5-10% of plasticizer, 2-8% of antioxidant, 25-45% of cellulose high molecular polymer and 5-20% of synthetic resin SAP polymer, wherein the cellulose high molecular polymer is modified by chitosan or quaternary ammonium salt bacteriostatic agent; (2) adding a rubber elastomer and tackifying resin into a double-planetary kneader, kneading and stirring for 2 hours, then adding a plasticizer and an antioxidant, kneading and stirring for 1 hour, then adding a modified cellulose-based high-molecular polymer and a synthetic resin-based SAP polymer, and stirring while adding; and continuously stirring for 1 hour to obtain the hydrocolloid dressing glue with the self-inhibiting effect. By using the glue, the liquid absorption speed is high, the liquid absorption amount is large, and a proper moist environment is provided for the wound.
Description
Technical Field
The invention relates to hydrocolloid dressing glue with a self-bacteria inhibiting effect and a preparation method thereof, and belongs to the field of medical dressings.
Background
The hydrocolloid is mainly formed by mixing an elastomer high polymer material, a plasticizer, tackifying resin and a hydrophilic high polymer material. Has both adhesive and liquid absorbing functions. General air permeability and liquid absorption of dressings for wound care are key indexes influencing wound repair, water vapor discharged by skin with poor air permeability cannot be effectively volatilized, skin itching and red swelling can occur, blisters can be generated in serious cases, and seepage liquid after blisters are festered is easy to breed bacteria to cause infection; the liquid absorption determines that the exudate discharged by the wound can not be absorbed in time, and the dressing after absorbing the liquid can provide a necessary humid environment for wound healing, and the absorbed exudate or the redundant exudate contains high protein and is most easy to breed bacteria, so that the wound is further infected if the dressing is not replaced in time. And frequent replacement brings high treatment cost to the patient. The glue provided by the invention is used for modifying the dressing imbibing material, so that the dressing imbibing material can absorb liquid quickly, and simultaneously, the breeding of bacteria can be inhibited, the problem that a wound is susceptible to infection is solved, and the treatment cost of a patient is reduced.
Disclosure of Invention
Aiming at the problems, the invention provides hydrocolloid dressing glue with self-inhibiting effect and a preparation method thereof to solve the defects of the existing dressing.
The invention aims to realize the self-antibacterial hydrocolloid dressing glue, which is characterized by comprising the following components in percentage by mass: 15-40% of rubber elastomer, 10-30% of tackifying resin, 5-10% of plasticizer, 2-8% of antioxidant, 25-45% of cellulose high molecular polymer and 5-20% of synthetic resin SAP polymer; wherein, the cellulose high molecular polymer is modified by chitosan or quaternary ammonium salt bacteriostatic agent.
The rubber elastomer is one or a combination of more of styrene-isoprene-styrene, polybutadiene rubber, styrene-butadiene rubber and ethylene propylene rubber.
The tackifying resin comprises one or a mixture of more of petroleum resin, rosin resin, terpene resin, phenolic resin and the like and derivative resin thereof.
The plasticizer comprises one or a combination of several of paraffin oil, naphthenic oil, mineral oil and low molecular weight polyolefin.
The antioxidant comprises one or a combination of more of aromatic amine antioxidant, phenol antioxidant and auxiliary antioxidant.
The cellulose high molecular polymer comprises one or a combination of more of carboxymethyl cellulose, ethyl cellulose, hydroxyethyl cellulose and carboxymethyl hydroxyethyl cellulose.
The synthetic resin SAP polymer comprises one or a combination of more of polyacrylate, polyvinyl alcohol and polyoxyalkylene.
When the cellulose high molecular polymer is modified, the unmodified cellulose high molecular polymer and the chitosan or quaternary ammonium salt bacteriostatic agent are soaked together for at least 12 hours by a soaking method, and the cellulose high molecular polymer modified by the chitosan or quaternary ammonium salt bacteriostatic agent is obtained by drying and grinding the cellulose high molecular polymer and the chitosan or quaternary ammonium salt bacteriostatic agent into 200-mesh powder after the soaking is finished.
A preparation method of hydrocolloid dressing glue with a self-antibacterial effect is characterized by comprising the following steps:
(1) preparing raw materials, wherein the raw materials comprise the following raw materials in percentage by mass: 15-40% of rubber elastomer, 10-30% of tackifying resin, 5-10% of plasticizer, 2-8% of antioxidant, 25-45% of cellulose high molecular polymer and 5-20% of synthetic resin SAP polymer, wherein the cellulose high molecular polymer is modified by chitosan or quaternary ammonium salt bacteriostatic agent;
(2) adding a rubber elastomer and tackifying resin into a double-planetary kneader, heating to 100-;
after the cellulose high molecular polymer and the synthetic resin SAP polymer are completely added, stirring is continuously carried out for 1 hour, and the hydrocolloid dressing glue with the self-bacteriostasis function is obtained.
The method also comprises a step (3) of preparing the hydrocolloid dressing glue with the self-inhibition effect prepared in the step (2) into a glue strip or a glue block suitable for subsequent coating.
The method is advanced and scientific, and the substance with the self-inhibition function of the glue is cellulose high molecular polymer which is modified by bacteriostatic agents such as chitosan or quaternary ammonium salt. The synthetic resin SAP polymer is added to increase the water absorption and water locking performance of the glue, increase the strength of changing colloid imbibition into gel, and reduce the risk of gel residue on the wound during removal. By using the glue, the liquid absorption speed is high, the liquid absorption amount is large, a proper humid environment is provided for the wound, and the modified water absorption material inhibits the breeding and reproduction of bacteria in the exudate while absorbing the exudate, so that the effect of reducing wound infection is achieved, and the wound is helped to be quickly repaired.
Detailed Description
The present invention will be described in further detail with reference to specific embodiments.
A hydrocolloid dressing glue with a self-inhibiting effect comprises the following components in percentage by mass: 15-40% of rubber elastomer, 10-30% of tackifying resin, 5-10% of plasticizer, 2-8% of antioxidant, 25-45% of cellulose high molecular polymer and 5-20% of synthetic resin SAP polymer; wherein, the cellulose high molecular polymer is modified by chitosan or quaternary ammonium salt bacteriostatic agent. When prepared, the method comprises the following steps:
(1) preparing raw materials, wherein the raw materials comprise the following raw materials in percentage by mass: 15-40% of rubber elastomer, 10-30% of tackifying resin, 5-10% of plasticizer, 2-8% of antioxidant, 25-45% of cellulose high molecular polymer and 5-20% of synthetic resin SAP polymer, wherein the cellulose high molecular polymer is modified by chitosan or quaternary ammonium salt bacteriostatic agent;
(2) adding a rubber elastomer and tackifying resin into a double-planetary kneader, heating to 100-;
after the cellulose high molecular polymer and the synthetic resin SAP polymer are completely added, continuously stirring for 1 hour to obtain the hydrocolloid dressing glue with the self-antibacterial effect;
(3) and (3) preparing the hydrocolloid dressing glue with the self-bacteriostasis function prepared in the step (2) into an adhesive tape or an adhesive block suitable for subsequent coating.
Wherein the rubber elastomer is one or a combination of more of styrene-isoprene-styrene, polybutadiene rubber, styrene-butadiene rubber and ethylene propylene rubber; the tackifying resin comprises one or a mixture of more of petroleum resin, rosin resin, terpene resin, phenolic resin and the like and derivative resin thereof; the plasticizer comprises one or more of paraffin oil, naphthenic oil, mineral oil and low molecular weight polyolefin; the antioxidant comprises one or a combination of more of aromatic amine antioxidant, phenol antioxidant and auxiliary antioxidant; the cellulose high molecular polymer comprises one or more of carboxymethyl cellulose, ethyl cellulose, hydroxyethyl cellulose and carboxymethyl hydroxyethyl cellulose; the synthetic resin SAP polymer comprises one or more of polyacrylate, polyvinyl alcohol, and polyoxyalkylene.
When cellulose high molecular polymer is modified, unmodified cellulose high molecular polymer and chitosan or quaternary ammonium salt bacteriostatic agent are soaked together for at least 12 hours by a soaking method, and after soaking, the cellulose high molecular polymer is dried and ground into 200-mesh powder, so that the cellulose high molecular polymer modified by the chitosan or quaternary ammonium salt bacteriostatic agent is obtained.
Claims (10)
1. The hydrocolloid dressing glue with the self-antibacterial effect is characterized by comprising the following components in percentage by mass: 15-40% of rubber elastomer, 10-30% of tackifying resin, 5-10% of plasticizer, 2-8% of antioxidant, 25-45% of cellulose high molecular polymer and 5-20% of synthetic resin SAP polymer; wherein, the cellulose high molecular polymer is modified by chitosan or quaternary ammonium salt bacteriostatic agent.
2. The hydrocolloid dressing glue with self-inhibiting effect of claim 1, which is characterized in that: the rubber elastomer is one or a combination of more of styrene-isoprene-styrene, polybutadiene rubber, styrene-butadiene rubber and ethylene propylene rubber.
3. The hydrocolloid dressing glue with self-inhibiting effect of claim 1, which is characterized in that: the tackifying resin comprises one or a mixture of more of petroleum resin, rosin resin, terpene resin, phenolic resin and the like and derivative resin thereof.
4. The hydrocolloid dressing glue with self-inhibiting effect of claim 1, which is characterized in that: the plasticizer comprises one or a combination of several of paraffin oil, naphthenic oil, mineral oil and low molecular weight polyolefin.
5. The hydrocolloid dressing glue with self-inhibiting effect of claim 1, which is characterized in that: the antioxidant comprises one or a combination of more of aromatic amine antioxidant, phenol antioxidant and auxiliary antioxidant.
6. The hydrocolloid dressing glue with self-inhibiting effect of claim 1, which is characterized in that: the cellulose high molecular polymer comprises one or a combination of more of carboxymethyl cellulose, ethyl cellulose, hydroxyethyl cellulose and carboxymethyl hydroxyethyl cellulose.
7. The hydrocolloid dressing glue with self-inhibiting effect of claim 1, which is characterized in that: the synthetic resin SAP polymer comprises one or a combination of more of polyacrylate, polyvinyl alcohol and polyoxyalkylene.
8. The hydrocolloid dressing glue with self-inhibiting effect of claim 1, which is characterized in that: when the cellulose high molecular polymer is modified, the unmodified cellulose high molecular polymer and the chitosan or quaternary ammonium salt bacteriostatic agent are soaked together for at least 12 hours by a soaking method, and the cellulose high molecular polymer modified by the chitosan or quaternary ammonium salt bacteriostatic agent is obtained by drying and grinding the cellulose high molecular polymer and the chitosan or quaternary ammonium salt bacteriostatic agent into 200-mesh powder after the soaking is finished.
9. A method for preparing hydrocolloid dressing glue with self-inhibiting effect as claimed in any of claims 1 to 8, characterized by comprising the following steps:
(1) preparing raw materials, wherein the raw materials comprise the following raw materials in percentage by mass: 15-40% of rubber elastomer, 10-30% of tackifying resin, 5-10% of plasticizer, 2-8% of antioxidant, 25-45% of cellulose high molecular polymer and 5-20% of synthetic resin SAP polymer, wherein the cellulose high molecular polymer is modified by chitosan or quaternary ammonium salt bacteriostatic agent;
(2) adding a rubber elastomer and tackifying resin into a double-planetary kneader, heating to 100-;
after the cellulose high molecular polymer and the synthetic resin SAP polymer are completely added, stirring is continuously carried out for 1 hour, and the hydrocolloid dressing glue with the self-bacteriostasis function is obtained.
10. The method of claim 9, further comprising: the method also comprises a step (3) of preparing the hydrocolloid dressing glue with the self-inhibition effect prepared in the step (2) into a glue strip or a glue block suitable for subsequent coating.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010533072.8A CN111643718A (en) | 2020-06-12 | 2020-06-12 | Hydrocolloid dressing glue with self-bacterium-inhibiting effect and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010533072.8A CN111643718A (en) | 2020-06-12 | 2020-06-12 | Hydrocolloid dressing glue with self-bacterium-inhibiting effect and preparation method thereof |
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| CN111643718A true CN111643718A (en) | 2020-09-11 |
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| CN202010533072.8A Pending CN111643718A (en) | 2020-06-12 | 2020-06-12 | Hydrocolloid dressing glue with self-bacterium-inhibiting effect and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113769158A (en) * | 2021-09-10 | 2021-12-10 | 湖北大学 | A kind of bionic dry and wet adhesion self-adjusting dressing and preparation method and application thereof |
| CN114190616A (en) * | 2021-12-03 | 2022-03-18 | 厦门悠派无纺布制品有限公司 | A kind of antibacterial disposable non-woven underwear and preparation method thereof |
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| US20020037945A1 (en) * | 1997-05-30 | 2002-03-28 | Anders Christian Nielsen | Adhesive agent and use of such adhesive agent |
| US20030225356A1 (en) * | 2002-05-24 | 2003-12-04 | Kulichikhin Valery G. | Composition for cushions, wound dressings and other skin-contacting products |
| CN102716509A (en) * | 2012-06-25 | 2012-10-10 | 武汉纺织大学 | Antibacterial hydrocolloid and preparation method of antibacterial hydrocolloid |
| CN104225663A (en) * | 2014-09-19 | 2014-12-24 | 南阳市汇博生物技术有限公司 | Antibacterial hydrocolloid dressing and preparation method thereof |
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| CN113769158A (en) * | 2021-09-10 | 2021-12-10 | 湖北大学 | A kind of bionic dry and wet adhesion self-adjusting dressing and preparation method and application thereof |
| CN114190616A (en) * | 2021-12-03 | 2022-03-18 | 厦门悠派无纺布制品有限公司 | A kind of antibacterial disposable non-woven underwear and preparation method thereof |
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