CN111616684A - Endoscope biopsy device with early canceration primary screening and positioning functions of mucous membrane tissues - Google Patents
Endoscope biopsy device with early canceration primary screening and positioning functions of mucous membrane tissues Download PDFInfo
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- CN111616684A CN111616684A CN202010534364.3A CN202010534364A CN111616684A CN 111616684 A CN111616684 A CN 111616684A CN 202010534364 A CN202010534364 A CN 202010534364A CN 111616684 A CN111616684 A CN 111616684A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/0233—Pointed or sharp biopsy instruments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/06—Biopsy forceps, e.g. with cup-shaped jaws
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Abstract
An endoscope biopsy device with the function of primary screening and positioning of early canceration of mucosal tissue comprises a host, a computer system and a biopsy forceps with a light guide system; the host is respectively connected with the computer system and the light guide system and comprises a 340nm light excitation system, an excitation light enhancement focusing system, a fluorescence signal receiving system, a fluorescence signal amplifying system and a fluorescence spectrum distinguishing system which are sequentially connected; the optical guide system is composed of an optical guide integrated part and an optical guide free part which are connected in sequence, the output end of the 340nm optical excitation system is connected with the port of the optical guide free part through an interface, the input end of the fluorescence signal receiving system is connected with the port of the optical guide free part, the optical guide free part is an optical fiber, and the optical guide integrated part comprises the optical fiber and a biopsy forceps.
Description
Technical Field
The invention relates to early canceration of mucosa tissues, in particular to an endoscope biopsy device with a primary screening and positioning function of early canceration of mucosa tissues.
Background
Intraepithelial neoplasia and early carcinoma of the mucosa, which is often not significantly altered in macroscopic morphology. At present, the electronic endoscope adopts white light to collect images and does not have the function of identifying and primarily screening the lesions. The biopsy is therefore somewhat blind.
The principle of 'fluorescence spectrum discrimination' for primary screening of intraepithelial neoplasia and early cancer lesions is as follows: the "fluorescence spectrum discrimination" is to use special excitation light (340nm) to excite the tissue to emit intrinsic fluorescence (also called autofluorescence) to diagnose mucosal cancer and intraepithelial neoplasia. Fluorescence generation is caused by changes in quantum states within the molecular structure, and the wavelength of fluorescence has a specific relationship with the quantum states within the molecular structure. If the quantum state changes within the molecular structure, the wavelength of the reflected intrinsic fluorescence will be different. Since the molecular structure of intraepithelial neoplasia and cancer tissue changes in internal quantum state, and the wavelength of the emitted intrinsic fluorescence differs from that of normal tissue, it is possible to distinguish intraepithelial neoplasia and cancer tissue. The primary screening of the intraepithelial neoplasia and the early cancer by utilizing the principle is the 'fluorescence spectrum discrimination'. Intrinsic fluorescence is much weaker than fluorescent staining. Intrinsic fluorescence in diagnosis of long-lumen mucosal lesions, signal recovery of intrinsic fluorescence requires signal receiving, signal amplification and signal analysis system technology.
The diameter of the optical fiber is limited by integrating the optical fiber into the biopsy forceps, so that the excitation light enhancement focusing technology is needed in the transmission link of the excitation light.
Disclosure of the invention
At present, the electronic endoscope used in hospitals adopts CCD to collect images under white light. Intraepithelial neoplasia and earlier early carcinomas have no significant mucosal changes in gross images. When inserting a biopsy forceps biopsy, the biopsy is blind because of the lack of guidance. The invention relates to an endoscope biopsy forceps with the function of primary screening and positioning early cancer of mucosa tissues, which is used for fixed-point biopsy of lesions under the guidance of primarily determining intraepithelial neoplasia and early cancer by inherent fluorescent signals. Is called a biopsy forceps with the primary screening and positioning functions of utilizing fluorescence spectrum to distinguish. The existing biopsy forceps do not have the special function, and the special biopsy forceps integrated with the fluorescence spectrum distinguishing function is an initiated technology and has originality;
the function of the kit in judging early canceration of the mucous membrane tissue ensures that the kit has important practicability in clinical application;
the technical problem that the optical fiber with input and output functions is integrated in the biopsy forceps with the diameter of only 3mm, the exciting light is not weak after being input, and the weak intrinsic fluorescence signal is transmitted out is accepted by the device is significant. The method mainly comprises an enhanced focusing technology of excitation light and an amplification technology of weak intrinsic fluorescence signals, and a technology of integrating optical fibers in a biopsy forceps. Therefore, the technical invention has great advancement.
The device of the invention consists of a host machine, a biopsy forceps with optical fibers and a computer printing system. The host machine consists of a special light (340nm) excitation system, an excitation light enhancement system, a fluorescence signal receiving system, a fluorescence signal amplification system and a fluorescence signal analysis system; the special light (340nm) excitation system is connected with the light guide transmission fiber of the light guide system through a host interface, and the excitation light is introduced into the detected mucous membrane through enhancement to excite the inherent fluorescence; and the optical transmission fiber transmits the intrinsic fluorescence signal and is connected with a signal receiving system of the host through the host interface. The fluorescence signal analysis system of the host is connected with a computer; the computer is connected with the printer to print the analyzed spectrum. The front part of the biopsy forceps with the light guide system, namely the part extending into the biopsy hole is a light guide integrated part; the back part of the biopsy forceps with the light guide system is composed of a biopsy collecting handle and a light guide free part; the free part of the light guide is connected with an interface of the host machine, and the free part of the light guide respectively plays a role in transmitting the exciting light and transmitting the inherent fluorescence formed after the excitation to be received by a signal receiving system of the host machine.
The technical solution of the invention is as follows:
an endoscope biopsy device with the function of primary screening and positioning of early canceration of mucosal tissue is characterized by comprising a host, a computer system and a biopsy forceps with a light guide system; the host is respectively connected with the computer system and the light guide system, and comprises a 340nm light excitation system, an excitation light enhancement system, a fluorescence signal receiving system, a fluorescence signal amplification system and a fluorescence spectrum discrimination system which are sequentially connected; the optical guide system is composed of an optical guide integrated part and an optical guide free part which are connected in sequence, the output end of the 340nm optical excitation system is connected with the port of the optical guide free part through an interface, the input end of the signal receiving system is connected with the port of the optical guide free part, the optical guide free part is an optical fiber, and the optical guide integrated part comprises the optical fiber and a biopsy forceps.
When the computer system comprises a computer host, a display screen and a printer, when the computer system is used, under the control of the host, the 340nm light excitation system is started, the 340nm light is output and irradiated and excited on the human mucosal tissue to be detected through the exciting light enhanced focusing, the light guide fiber of the light guide system connected with the light guide fiber and the biopsy hole of the endoscope, the inherent fluorescence generated by the human mucosal tissue returns through the light guide fiber and is input into the fluorescence spectrum discrimination system through the fluorescence signal receiving system and the fluorescence signal amplifying system in sequence, and the inherent fluorescence spectrum output by the fluorescence spectrum discrimination system is displayed on the display screen through the computer host.
And a socket part for inserting and connecting the light guide system is arranged on the shell of the host machine.
The invention has the beneficial effects that:
the most effective measures for improving the survival rate of the tumor are early diagnosis and early treatment at present. In the case of gastric cancer, if it is detected at the early stage of cancer, the survival rate can reach more than 90% 5 years after the operation. The inherent fluorescence detection is particularly suitable for diagnosing early carcinoma of the mucosa epithelium and even intraepithelial neoplasia, thereby having important significance for reducing the late progression and mortality of some common mucosa epithelial carcinoma and having great social value.
Technically, no biopsy forceps with the function of preliminarily distinguishing tissue canceration exist all over the world at present. Mucosal changes in intraepithelial neoplasia (precancerous lesions) and early stage carcinogenesis in the mucosa are not evident in gross morphological (macroscopic changes). Traditional biopsy is blind biopsy under white light CCD guide, and can not detect precancerous lesion and early cancer lesion with gross inconspicuous change. Therefore, the biopsy forceps with the function of identifying the cancerous tissue by the fluorescence spectrum added with the high-tip technology has a great technical effect. Meanwhile, the biopsy forceps added with the function of preliminarily distinguishing early cancer and intraepithelial neoplasia of the mucosa tissue by the inherent fluorescence spectrum add competitive strength to the market of manufacturers, and have great economic benefit.
Drawings
FIG. 1 is a schematic diagram showing the discrimination of fluorescence spectra of early cancer and normal tissues
FIG. 2 is a schematic view showing the discrimination of fluorescence spectra of intraepithelial neoplasia and normal tissue
FIG. 3 is a schematic structural diagram of a main machine of an endoscopic biopsy device with a function of primary screening and positioning for early canceration of mucosal tissue according to the present invention
FIG. 4 shows the light guide system and the main unit of the endoscopic biopsy device with the function of positioning the early stage canceration of the mucosa tissue according to the present invention
Connection structure
FIG. 5 is a schematic structural diagram of an endoscopic biopsy forceps embodiment 1 with a function of primary screening and positioning for early stage canceration of mucosal tissue according to the present invention
FIG. 6 is a schematic structural view of an endoscopic biopsy forceps embodiment 2 with a function of primary screening and positioning for early stage canceration of mucosal tissue according to the present invention
FIG. 7 is a schematic diagram of an excitation light enhanced focusing system of a main unit in an endoscopic biopsy device with a function of primary screening and positioning for early stage canceration of mucosal tissue according to the present invention
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments obtained by a person skilled in the art based on the embodiments of the present invention without any inventive step are within the scope of the present invention.
The biopsy forceps with the fluorescence spectrum distinguishing function is provided with a device with the fluorescence spectrum distinguishing function for primarily judging mucosal lesions. The device consists of a special light (340nm) excitation system, an excitation light enhancement focusing system, biopsy forceps integrating a light guide system (light guide fiber), a fluorescent signal receiving system, a fluorescent signal amplifying system, a fluorescent signal analyzing system (spectrum method), a computer and a printing system.
It can be classified into three parts:
the first part consists of a special light (340nm) excitation system, an excitation light enhancement focusing system and a fluorescence signal receiving, amplifying and analyzing system, and forms a host. (see fig. 3)
The second part is a biopsy forceps device with a light guide system, the light guide fiber of the light guide system is divided into a front part and a rear part, the light guide fiber at the front part and the biopsy forceps are combined into a whole to form an integrated part, and the integrated part and the biopsy forceps are inserted into a biopsy hole of an endoscope together during application; the rear part is a free part which is connected with the host through an interface. (see fig. 4)
The third part is a computer printing system.
Wherein, the biopsy forceps integrating the optical fiber is a technical key, and the cross section of the biopsy forceps is schematically shown (as figure 5); biopsy forceps extension forceps extraction schematic (see fig. 6); the optical fiber integrated in the biopsy forceps with the diameter of 3mm is thin, and the exciting light needs to be focused and introduced by an enhanced focusing system, and the structure of the optical fiber is schematically shown (as shown in FIG. 7).
Example 1
An endoscope biopsy device with the function of primary screening and positioning of early canceration of mucosa tissues comprises a host, a computer system and a light guide system; the host is respectively connected with a computer system and a light guide system 6, and comprises a 340nm light excitation system 1, an excitation light enhancement focusing system 2, a fluorescence signal receiving system 3, a fluorescence signal amplifying system 4 and a fluorescence spectrum distinguishing system 5 which are sequentially connected; the light guide system 6 is divided into a light guide integrated part 7 and a light guide free part 8. The 340nm light excitation system 1 is connected with one end of a transmitting optical fiber through an interface at the output end of the excitation light enhancement focusing system 2, the input end of the fluorescence signal receiving system is connected with one end of a receiving optical fiber, the transmitting optical fiber and the receiving optical fiber penetrate through the light guide free part and the light guide integrated part 7, and a biopsy forceps is further arranged at the light guide integrated part and integrated with the optical fiber into a whole, as shown in fig. 5. And a socket part for inserting and connecting the light guide system is also arranged on the shell of the host machine.
The computer system comprises a computer host 9, a display screen 10 and a printer 11. When the fluorescent spectrum distinguishing system is used, under the control of the host, the 340nm light excitation system is started, the output 340nm light is irradiated and excited on the human mucous membrane tissue to be detected through the light guide fiber of the light guide system and the biopsy hole of the endoscope through enhanced focusing, the inherent fluorescent light generated by the human mucous membrane tissue returns through the light guide fiber and is input into the fluorescent spectrum distinguishing system through the fluorescent signal receiving system and the fluorescent signal amplifying system in sequence, and the inherent fluorescent spectrum output by the fluorescent spectrum distinguishing system is displayed on the display screen through the computer host.
Example 2
The difference from the embodiment 1 is that the optical fiber is separated from the biopsy forceps, and when the optical fiber is used, the optical fiber is respectively inserted into the biopsy hole of the endoscope in front and back, so that the application is limited and inconvenient.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, but not to limit the same; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the spirit and scope of the technical solutions of the embodiments of the present invention.
Claims (4)
1. An endoscope biopsy device with a function of primary screening and positioning early canceration of mucosa tissues is characterized by comprising a host, a computer system and a biopsy forceps with a light guide system; the host is respectively connected with the computer system and the light guide system and comprises a 340nm light excitation system, an excitation light enhancement focusing system, a fluorescence signal receiving system, a fluorescence signal amplification system and a fluorescence spectrum discrimination system which are sequentially connected; the optical guide system is composed of an optical guide integrated part and an optical guide free part which are connected in sequence, the output end of the 340nm optical excitation system is connected with the port of the optical guide free part through an interface, the input end of the signal receiving system is connected with the port of the optical guide free part, the optical guide free part is an optical fiber, and the optical guide integrated part comprises the optical fiber and a biopsy forceps.
2. The endoscopic biopsy device with the primary screening and positioning function for early stage cancer of mucosal tissue according to claim 1, wherein the computer system comprises a computer host, a display screen and a printer, when in use, under the control of the host, the 340nm light excitation system is started, 340nm light is output and irradiated and excited on the human tissue to be detected through the excitation light enhancement system, the light guide fiber of the light guide system and the biopsy hole of the endoscope, the intrinsic fluorescence generated by the human tissue returns through the light guide fiber and is input into the fluorescence spectrum discrimination system sequentially through the fluorescence signal receiving system and the fluorescence signal amplification system, and the intrinsic fluorescence spectrum output by the fluorescence spectrum discrimination system is displayed on the display screen through the computer host.
3. The endoscopic biopsy device with function of positioning early stage cancer of mucosa tissue as claimed in claim 1, wherein a socket portion for inserting and connecting the light guide system is provided on the housing of the main machine.
4. The endoscopic biopsy device with function of positioning early stage cancer of mucosal tissue as claimed in claim 1, wherein the biopsy forceps is integrated with the optical fiber to form an optical integrated part. Namely, the light guide integrated part comprises the light guide fiber and the biopsy forceps, so that the special biopsy forceps are formed.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010534364.3A CN111616684A (en) | 2020-06-12 | 2020-06-12 | Endoscope biopsy device with early canceration primary screening and positioning functions of mucous membrane tissues |
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| CN202010534364.3A CN111616684A (en) | 2020-06-12 | 2020-06-12 | Endoscope biopsy device with early canceration primary screening and positioning functions of mucous membrane tissues |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113499028A (en) * | 2021-07-30 | 2021-10-15 | 上海思坦德医疗科技有限公司 | Hysteroscope finder for early canceration of cervix or endometrium |
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| JPH09131349A (en) * | 1995-11-10 | 1997-05-20 | Asahi Optical Co Ltd | Treating tool for fluorescence observation endoscope |
| CN1493250A (en) * | 2002-10-31 | 2004-05-05 | ƽ | Device using endoscope to diagnose precancer affection |
| CN104586345A (en) * | 2015-01-19 | 2015-05-06 | 上海侃瑞仪器设备有限公司 | Inherent fluorescent precancerous lesion hysteroscopy diagnostic system |
| CN208371778U (en) * | 2017-08-24 | 2019-01-15 | 生标（上海）医疗器械科技有限公司 | Fluorescence solution picture morning cancer diagnostic equipment is strengthened in height filtering |
| CN212630750U (en) * | 2020-06-12 | 2021-03-02 | 王侃 | Endoscope biopsy device with early canceration of tissue prescreening locate function |
-
2020
- 2020-06-12 CN CN202010534364.3A patent/CN111616684A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09131349A (en) * | 1995-11-10 | 1997-05-20 | Asahi Optical Co Ltd | Treating tool for fluorescence observation endoscope |
| CN1493250A (en) * | 2002-10-31 | 2004-05-05 | ƽ | Device using endoscope to diagnose precancer affection |
| CN104586345A (en) * | 2015-01-19 | 2015-05-06 | 上海侃瑞仪器设备有限公司 | Inherent fluorescent precancerous lesion hysteroscopy diagnostic system |
| CN208371778U (en) * | 2017-08-24 | 2019-01-15 | 生标（上海）医疗器械科技有限公司 | Fluorescence solution picture morning cancer diagnostic equipment is strengthened in height filtering |
| CN212630750U (en) * | 2020-06-12 | 2021-03-02 | 王侃 | Endoscope biopsy device with early canceration of tissue prescreening locate function |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113499028A (en) * | 2021-07-30 | 2021-10-15 | 上海思坦德医疗科技有限公司 | Hysteroscope finder for early canceration of cervix or endometrium |
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Inventor after: Song Bogen Inventor after: Yan Guozheng Inventor after: Wang Kan Inventor before: Song Bogen Inventor before: Wang Kan |
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