CN111544319A - Toothpaste capable of inhibiting helicobacter pylori and preparation method thereof - Google Patents

Abstract

The invention discloses toothpaste capable of inhibiting helicobacter pylori and a preparation method thereof, wherein the toothpaste comprises the following components in parts by weight: component A27-36.5, component B57-82, component C0.35-1.3; the component A comprises: 25-30 parts of hydrated silica, 1-2.5 parts of glycerol laurate and 1-4 parts of cellulose gum; the component B comprises: sorbitol 40-55, IgY0.1-0.4, sodium pyrophosphate 0.04-0.06, cocamidopropyl betaine 1-2, tetrasodium glutamate diacetate 0.1-0.3, and water 10-15; the component C comprises: tranexamic acid 0.04-0.07, nisin 0.1-0.4. The invention adopts the IgY component to effectively inhibit helicobacter pylori in the oral cavity, thereby relieving and improving the problem of halitosis. The invention also adopts a plurality of food-grade antibacterial and antiviral components, and can simultaneously inhibit microorganisms causing food residue rotting in the oral cavity to cause tooth damage and oral inflammation, thereby further relieving the problem of halitosis.

Description

Toothpaste capable of inhibiting helicobacter pylori and preparation method thereof

Technical Field

The invention relates to daily chemical products, in particular to toothpaste, and particularly relates to toothpaste capable of inhibiting helicobacter pylori and a preparation method thereof.

Background

The toothpaste is a common daily chemical product at present, and mainly brushes teeth and oral cavities through the toothbrush, so that the effects of cleaning the teeth and the oral cavities and refreshing breath are achieved. However, with the irregular work and rest habits of people, oral hygiene and other habits, gum inflammation and oral ulcer are easily caused, so that a plurality of toothpaste manufacturers add anti-inflammatory components into toothpaste, so that the toothpaste can directly act on affected parts to achieve the effects of treating and preventing inflammation when in use. However, most of the anti-inflammatory components are medicinal components, and many of the anti-inflammatory components are raw materials of chemical synthesis, so that the long-term use of the anti-inflammatory components can affect the human health.

In addition, people pay more attention to their own image, and in particular, halitosis can greatly reduce the personal image, so that the prevention and treatment of halitosis is one of the urgent needs of people. After the infection of helicobacter pylori, the helicobacter pylori can cause gastritis, periodontitis and the like, so that halitosis is caused, and is very persistent and difficult to remove. In particular, helicobacter pylori can be transmitted through the mouth, and when taken together with a patient infected with helicobacter pylori, it is likely to cause the infection, thereby causing famous bad breath. The helicobacter pylori in the oral cavity is mostly recurrent with the helicobacter pylori in the stomach, and the helicobacter pylori is infectious, once one person is infected, one person is probably infected, and the helicobacter pylori causes family transmission.

Of course, many microorganisms in the oral cavity cause halitosis, such as gram-positive bacteria, staphylococci, streptococci, micrococcus, etc., which mainly cause halitosis, even periodontitis, ulcers, etc., by causing food residues in the oral cavity to spoil.

In view of the above, the need for preventing and treating halitosis has necessitated the suppression of harmful microorganisms in the oral cavity, as well as the suppression of H.pylori, to solve the problem of halitosis relatively comprehensively.

Disclosure of Invention

In view of the above-mentioned defects of the prior art, the technical problem to be solved by the present invention is to provide a toothpaste capable of inhibiting helicobacter pylori and a preparation method thereof, which can effectively inhibit helicobacter pylori, thereby avoiding halitosis caused by helicobacter pylori infection.

In order to achieve the aim, the invention provides toothpaste capable of inhibiting helicobacter pylori, which comprises the following components in parts by weight:

component A27-36.5, component B57-82, component C0.35-1.3;

the component A comprises: 25-30 parts of hydrated silica, 1-2.5 parts of glycerol laurate (lauric acid monoglyceride) and 1-4 parts of cellulose gum;

the component B comprises: sorbitol 40-55, IgY0.1-0.4, sodium pyrophosphate 0.04-0.06, cocamidopropyl betaine 1-2, water 10-15, glutamic diacetic acid tetrasodium 0.1-0.3; preferably, the component B also comprises 5-8 parts of glycerin, 0.5-1 part of carrageenan and 0.08-0.12 part of trichlorogalactose;

the component C comprises: tranexamic acid 0.04-0.07, nisin 0.1-0.4; preferably, the component C also comprises 0.1-0.4 of lysozyme and 0.1-0.4 of lactoferrin.

Preferably, the composition also comprises a component D, wherein the component D comprises 0.4-0.8 of mint extract and 0.05-0.08 of essence.

Preferably, the component B comprises the following components in parts by weight: sorbitol 40-55, IgY0.1-0.4, sodium pyrophosphate 0.04-0.06, cocamidopropyl betaine 1-2, water 10-15, glycerol 5-8, carrageenan 0.5-1, trichlorogalactose 0.08-0.12;

preferably, the component C comprises the following components in parts by weight: tranexamic acid 0.04-0.07, nisin 0.1-0.4, lysozyme 0.1-0.4, lactoferrin 0.1-0.4.

The preparation method of the toothpaste comprises the following steps:

s1, taking out the components of the component B in sequence according to the components, and stirring for 1-1.5 hours by ultrasonic waves to ensure that the components are uniformly stirred;

s2, taking out the components of the component A in sequence, ultrasonically stirring for 0.5-1 hour, pouring the stirred mixed solution into a stirrer of S1, uniformly mixing and stirring, and emulsifying;

s3, adding the component C into the stirrer of S2, and continuing stirring for 1-1.5 hours;

s5, homogenizing, and standing for 4-8 hours to obtain the toothpaste.

S4 is also included between S3 and S5, and the component D is poured into a stirrer of S3 and stirred for 0.5 to 1 hour.

The components include, but are not limited to, the following functions:

tetrasodium glutamate diacetate is well soluble in a wide pH range, has strong decontamination capability and can generate synergistic effect with a bactericide in a system.

The sorbitol is mainly used as a conditioning agent, has certain sweet taste and good mouthfeel, and can condition the taste of the toothpaste while preserving moisture.

Hydrated silica, also known as pure latex, hydrated silicon dioxide, charcoal black, hydrated silicic acid, the particles of which can rub against the teeth to better clean them, and also to thicken the toothpaste.

Cocamidopropyl betaine, an amphoteric surfactant, has excellent stability under acidic and alkaline conditions, presents respectively positive and negative polarity, is often used in combination with anionic, cationic and nonionic surfactants, and has good compatibility. The detergent has the advantages of small irritation, easy water dissolution, acid and alkali stability, more foams, strong detergency, excellent thickening property, softness, bactericidal property, antistatic property and hard water resistance. Can obviously improve the softness, the conditioning performance and the low-temperature stability of the toothpaste. In addition, the invention also has the functions of washing, moistening, thickening, antistatic, sterilization and the like.

Cellulose gum, as a binder, is used to "stick" the components together to form a stable paste.

Sodium pyrophosphate, also known as tetrasodium diphosphate, is classified into anhydrous substance and decahydrated substance. The decahydrate is colorless or white crystal or crystalline powder, and the anhydrous substance is white powder, soluble in water, and insoluble in ethanol and other organic solvents. Decahydrate is preferred in the present invention. It can dissolve insoluble salts of calcium and magnesium, thereby improving the detergency to teeth. In addition, sodium pyrophosphate has a deflocculation effect, can emulsify various grease components, can reduce the surface tension and the interfacial tension of the solution, and has a washing assisting effect.

Glyceryl laurate, lauric monoglyceride, also known as lauric monoglyceride, is a lipophilic nonionic surfactant, a compound naturally found in breast milk. The glycerol laurate can play a role in emulsification, is a safe, efficient and broad-spectrum antibacterial agent, is not limited by pH, and still has a good antibacterial effect under a neutral or slightly alkaline condition. The toothpaste can play a good antibacterial effect after being released in the oral cavity, and can be quickly emulsified when being prepared and used.

Tranexamic acid, also known as tranexamic acid, white crystalline powder; no smell, slightly bitter taste. The black-removing and spot-removing efficacy of the vitamin C is about 50 times higher than that of vitamin C, and is about 10 times higher than that of tartaric acid. The invention is mainly used for lightening the dental plaque.

The invention selects helicobacter pylori type IGY which can effectively inhibit helicobacter pylori, thereby inhibiting and improving halitosis caused by helicobacter pylori infection.

Lysozyme, also known as muramidase (muramidase) or N-acetylmuramylohydrolase (N-acetylmuramylolycanohydrolase), is an alkaline enzyme that hydrolyzes mucopolysaccharides in bacteria. Lysozyme dissolves bacteria by breaking the beta-1, 4 glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine in the cell wall, breaking down the cell wall insoluble mucopolysaccharide into soluble glycopeptides, causing the contents of the broken cell wall to escape. Lysozyme can also be directly combined with virus protein with negative charge, and forms a complex with DNA, RNA and apoprotein to inactivate the virus. Thereby inhibiting harmful microorganisms in the oral cavity and relieving halitosis caused by microorganism activity.

Lactoferrin, an important non-heme iron-binding glycoprotein in milk, is a monomeric glycoprotein with bactericidal activity in neutrophil granules. It has broad-spectrum antibacterial, antioxidant, anticancer, immune system regulating, and disease resistance enhancing effects, and can further inhibit microorganisms in oral cavity.

Nisin, also known as nisin, has a strong inhibitory effect on gram-positive bacteria, including staphylococcus, streptococcus, micrococcus, and other pathogens that cause food spoilage and are harmful to human health. If the nisin is added into food in parts per million to parts per million, the nisin can sufficiently inhibit the growth and the propagation of a plurality of gram-positive bacteria causing food spoilage, and is a natural food preservative with high efficiency and no toxicity.

Water as solvent and blender to dissolve and homogenize the water soluble components.

Glycerol is a colorless, odorless, sweet substance in clear, viscous, liquid form, and has high moisturizing effect.

Essence for regulating smell and taste.

Carrageenan, which prevents re-staining, improves the dispersion and storage properties of the toothpaste and also provides a smooth, soft product with improved emulsion stability.

Trichlorogalactose is used as surfactant, dispersant and stabilizer, and can be used for regulating taste, and as correctant and sweetener.

Herba Menthae extract has antiinflammatory, antibacterial, and breath freshening effects.

The invention has the beneficial effects that:

the invention adopts the IgY component to effectively inhibit helicobacter pylori in the oral cavity, thereby relieving and improving the problem of halitosis. The invention also adopts a plurality of food-grade antibacterial and antiviral components, and can simultaneously inhibit microorganisms causing food residue rotting in the oral cavity to cause tooth damage and oral inflammation, thereby further relieving the problem of halitosis.

The invention also has the functions of cleaning the oral cavity, relieving tooth stains, whitening teeth, reducing dental plaque, refreshing breath, refreshing mouth feel, reducing oral bacteria, maintaining the health of teeth and periodontal tissues (including gingiva) and keeping the oral health.

Detailed Description

The invention is further illustrated by the following examples:

the first embodiment is as follows:

the preparation method of the toothpaste of this example is as follows:

s1, taking out the components of the component B in sequence according to the components, and stirring for 1-1.5 hours by ultrasonic waves to ensure that the components are uniformly stirred;

s2, taking out the components of the component A in sequence, ultrasonically stirring for 0.5-1 hour, pouring the stirred mixed solution into a stirrer of S1, uniformly mixing and stirring, and emulsifying;

s3, adding the component C into the stirrer of S2, and continuing stirring for 1-1.5 hours;

s4, pouring the component D into a stirrer of S3, and stirring for 0.5-1 hour; if component D is absent, this step is omitted;

s5, homogenizing, and standing for 4-8 hours to obtain the toothpaste.

Different toothpastes were prepared according to the preparation method of the invention according to table 1:

TABLE 1

After each toothpaste is prepared, the toothpaste is put into a toothpaste tube, and the use amount of the toothpaste is easy to control because the caliber of the toothpaste tube is standard.

Example two:

selecting 100 helicobacter pylori positive patients with halitosis (bad breath or bad smell in oral cavity), dividing 100 non-helicobacter pylori positive and halitosis patients into five groups, wherein each group comprises 20 helicobacter pylori positive patients and 20 non-helicobacter pylori positive and halitosis patients, and respectively designating experiment group 1, experiment group 2, experiment group 3, experiment group 4 and control group, the experiment group 1, experiment group 2, experiment group 3, experiment group 4 and control group respectively correspond to the first toothpaste, second toothpaste, third toothpaste, fourth toothpaste and control group toothpaste in the first embodiment, the toothpaste is used in the morning and evening once every day, and is about one centimeter (about 1 g) every time, the common soft-hair toothbrush is used for brushing teeth for at least 5 minutes every time, the test period is continuous for 8 weeks, statistics of results is carried out once a week, and the statistical results are as follows (table 2):

TABLE 2 (Unit: person)

In table 2, HP represents HP positive patients, and non-HP represents non-HP positive but halitosis patients. The number of people turning to negative is obtained by detecting saliva two hours after tooth brushing through the helicobacter pylori kit, the halitosis is improved to some extent, and the halitosis is obviously improved through the approach of testers and workers (the nose is detected within the range of 10-15 cm in the oral cavity of the testers), and the people can not eat food within two hours after tooth brushing and can only drink clear water. The test time is after evening use every week, and the starting point of the test period is when morning use next week. The criteria for significant improvement in halitosis were the substantial absence of off-flavors or halitosis. The criteria for improvement of bad breath is a significant reduction of bad breath.

As can be seen from the above table, HP-positive patients turned significantly negative after a continuous four week use, and halitosis was greatly improved, with the malodor essentially disappearing in most of the tests after a continuous 8 week use. The principle is mainly to inhibit helicobacter pylori and other microorganisms which can cause fast food decay and oral inflammation, thereby improving the oral environment and fundamentally solving the problem of halitosis.

The invention is not described in detail, but is well known to those skilled in the art.

The foregoing detailed description of the preferred embodiments of the invention has been presented. It should be understood that numerous modifications and variations could be devised by those skilled in the art in light of the present teachings without departing from the inventive concepts. Therefore, the technical solutions available to those skilled in the art through logic analysis, reasoning and limited experiments based on the prior art according to the concept of the present invention should be within the scope of protection defined by the claims.

Claims (10)

1. The toothpaste capable of inhibiting helicobacter pylori is characterized by comprising the following components in parts by weight:

component A27-36.5, component B57-82, component C0.35-1.3;

the component A comprises: 25-30 parts of hydrated silica, 1-2.5 parts of glycerol laurate and 1-4 parts of cellulose gum;

the component B comprises: sorbitol 40-55, IgY0.1-0.4, sodium pyrophosphate 0.04-0.06, cocamidopropyl betaine 1-2, water 10-15, glutamic diacetic acid tetrasodium 0.1-0.3;

the component C comprises: tranexamic acid 0.04-0.07, nisin 0.1-0.4.

2. The toothpaste of claim 1, further comprising component D, wherein component D comprises peppermint extract 0.4-0.8, and flavor 0.05-0.08.

3. The toothpaste according to claim 1, wherein the component B comprises the following components in parts by weight: sorbitol 40-55, IgY0.1-0.4, sodium pyrophosphate 0.04-0.06, cocamidopropyl betaine 1-2, water 10-15, tetrasodium glutamate diacetate 0.1-0.3, glycerol 5-8, carrageenan 0.5-1, and trichlorogalactose 0.08-0.12.

4. The toothpaste according to any one of claims 1 to 3, wherein component C is composed of the following components in parts by weight: tranexamic acid 0.04-0.07, nisin 0.1-0.4, lysozyme 0.1-0.4, lactoferrin 0.1-0.4.

5. The toothpaste according to claim 1, which comprises the following components in parts by weight: hydrated silica 26, glycerol laurate 1, cellulose gum 3, sorbitol 45, igy0.2, sodium pyrophosphate 0.5, cocamidopropyl betaine 1.2, water 13, tetrasodium glutamate diacetate 0.1, tranexamic acid 0.05, nisin 0.2.

6. The toothpaste according to claim 1, which comprises the following components in parts by weight: hydrated silica 30, glyceryl laurate 2, cellulose gum 2, sorbitol 50, IgY0.3, sodium pyrophosphate 0.06, cocamidopropyl betaine 2, water 13, tetrasodium glutamate diacetate 0.25, tranexamic acid 0.07, nisin 0.3.

7. The toothpaste according to claim 4, which comprises the following components in parts by weight: hydrated silica 26, glycerol laurate 1, cellulose gum 3, sorbitol 45, IgY0.2, sodium pyrophosphate 0.5, cocamidopropyl betaine 1.2, water 13, tetrasodium glutamate diacetate 0.1, glycerol 6, carrageenan 0.8, trichlorogalactose 0.08, tranexamic acid 0.05, nisin 0.2, lysozyme 0.2, lactoferrin 0.2, mint extract 0.5, and essence 0.06.

8. The toothpaste according to claim 4, which comprises the following components in parts by weight: 30 parts of hydrated silica, 2 parts of glycerol laurate, 2 parts of cellulose gum, 50 parts of sorbitol, 0.3 part of IgY0, 0.06 part of sodium pyrophosphate, 2 parts of cocamidopropyl betaine, 13 parts of water, 0.25 part of tetrasodium glutamate diacetate, 5-8 parts of glycerol, 0.6 part of carrageenan, 0.12 part of trichlorogalactose, 0.07 part of tranexamic acid, 0.3 part of nisin, 0.4 part of lysozyme, 0.4 part of lactoferrin, 0.8 part of mint extract and 0.08 part of essence.

9. A method of preparing a toothpaste according to any one of claims 1 to 8 comprising the steps of:

s1, taking out the components of the component B in sequence according to the components, and stirring for 1-1.5 hours by ultrasonic waves to ensure that the components are uniformly stirred;

s2, taking out the components of the component A in sequence, ultrasonically stirring for 0.5-1 hour, pouring the stirred mixed solution into a stirrer of S1, uniformly mixing and stirring, and emulsifying;

s3, adding the component C into the stirrer of S2, and continuing stirring for 1-1.5 hours;

s5, homogenizing, and standing for 4-8 hours to obtain the toothpaste.

10. The method of claim 9, further comprising, between S3 and S5, S4, pouring component D into the mixer of S3, and mixing for 0.5 to 1 hour.