CN111543991A - A device for measuring and evaluating electrical impedance of gastrointestinal mucosal epithelium - Google Patents
A device for measuring and evaluating electrical impedance of gastrointestinal mucosal epithelium Download PDFInfo
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- 230000002496 gastric effect Effects 0.000 title claims abstract description 34
- 210000000981 epithelium Anatomy 0.000 title claims abstract description 12
- 238000001514 detection method Methods 0.000 claims abstract description 63
- 238000005259 measurement Methods 0.000 claims abstract description 26
- 238000006073 displacement reaction Methods 0.000 claims description 25
- 230000005540 biological transmission Effects 0.000 claims description 10
- 238000011156 evaluation Methods 0.000 claims description 9
- 238000002847 impedance measurement Methods 0.000 claims description 8
- 230000004890 epithelial barrier function Effects 0.000 abstract description 9
- 230000002159 abnormal effect Effects 0.000 abstract description 7
- 238000012544 monitoring process Methods 0.000 abstract description 6
- 210000004082 barrier epithelial cell Anatomy 0.000 abstract description 4
- 238000013399 early diagnosis Methods 0.000 abstract description 4
- 230000004888 barrier function Effects 0.000 abstract description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 13
- 210000002784 stomach Anatomy 0.000 description 8
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- 210000003238 esophagus Anatomy 0.000 description 2
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
- A61B5/0531—Measuring skin impedance
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- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/273—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the upper alimentary canal, e.g. oesophagoscopes, gastroscopes
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
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- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
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Abstract
本发明公开一种胃肠道黏膜上皮电阻抗测量评估装置，包括套管和阻抗检测管，套管内设有检测通道，套管顶端为先端部，先端部上设有内窥镜和检测孔，检测孔为检测通道在先端部上的出口，套管中段设有调节器和行程测量盒，调节器上设有检测通道开口，与套管内的检测通道连通，阻抗检测管从调节器上的检测通道开口穿入，通过套管内的检测通道从先端部上的检测孔穿出，阻抗检测管端部设有阻抗传感器。本发明将阻抗传感器作为内镜的附件，可以在内镜观察时测量胃肠道黏膜上皮电阻抗，来评估胃肠道黏膜上皮屏障功能障碍，方便医生进行针对性治疗，且可以实时操作，反复监测，解决目前胃肠道黏膜上皮屏障功能异常早期诊断和监测的临床需求。
The invention discloses a device for measuring and evaluating the electrical impedance of gastrointestinal mucosal epithelium, comprising a sleeve and an impedance detection tube. A detection channel is arranged in the sleeve. The detection hole is the outlet of the detection channel on the front end. The middle section of the casing is provided with a regulator and a stroke measurement box. The regulator is provided with a detection channel opening, which is communicated with the detection channel in the casing, and the impedance detection tube is detected from the regulator. The channel opening is penetrated, and the detection channel in the casing passes through the detection hole on the front end, and the end of the impedance detection tube is provided with an impedance sensor. The invention uses the impedance sensor as an accessory of the endoscope, and can measure the electrical impedance of the gastrointestinal mucosal epithelium during endoscopic observation to evaluate the barrier function of the gastrointestinal mucosal epithelial barrier, which is convenient for doctors to carry out targeted treatment, and can be operated in real time. Repeatedly Monitoring, to solve the current clinical needs for early diagnosis and monitoring of abnormal gastrointestinal mucosal epithelial barrier function.
Description
技术领域：Technical field:
本发明涉及消化内科医疗辅助器械领域，具体涉及一种胃肠道黏膜上皮电阻抗测量评估装置。The invention relates to the field of medical aids in gastroenterology, in particular to a device for measuring and evaluating electrical impedance of gastrointestinal mucosal epithelium.
背景技术：Background technique:
胃肠道上皮屏障功能的破坏是多种肠道疾病，如炎症、肿瘤、功能性胃肠病等发生的重要机制，但对早期上皮屏障功能障碍(肉眼不可见)尚无诊断方法。目前评价胃肠道上皮屏障功能障碍主要有三种方法，第一：活检病理学评估，只能达到局部上皮评估的作用，难以多点评估，且对患者造成创伤损害，而且等待活检结果周期较长；第二：活检分子生物学评估方法，目前只在实验室中使用，尚未应用于临床；第三：共聚焦内镜，该方法需要局部使用显色剂，有过敏风险，且价格昂贵，只能局部操作，难以多点评估，并对内镜医师诊断水平要求较高。目前尚无简单方便的胃肠道上皮屏障功能异常早期诊断和监测的方法。The destruction of gastrointestinal epithelial barrier function is an important mechanism for the occurrence of various intestinal diseases, such as inflammation, tumor, functional gastrointestinal disease, etc., but there is no diagnostic method for early epithelial barrier dysfunction (invisible to the naked eye). At present, there are three main methods for evaluating gastrointestinal epithelial barrier dysfunction. The first is biopsy pathological evaluation, which can only achieve the role of local epithelial evaluation, is difficult to evaluate at multiple points, and causes trauma damage to patients, and the waiting period for biopsy results is long. ; Second: Biopsy molecular biology assessment method, which is currently only used in the laboratory and has not yet been used in clinical practice; Third: Confocal endoscopy, which requires topical use of chromogenic agents, has allergy risks, and is expensive. It can be operated locally, it is difficult to evaluate at multiple points, and it requires a high level of diagnosis of endoscopists. At present, there is no simple and convenient method for early diagnosis and monitoring of abnormal gastrointestinal epithelial barrier function.
发明内容：Invention content:
(一)解决的技术问题(1) Technical problems solved
针对现有技术的不足，本发明提供了一种胃肠道黏膜上皮电阻抗测量评估装置，将阻抗测量和内窥镜结合，在内窥镜操作的同时，简单方便地对胃肠道黏膜上皮屏障进行评估，且可以实时操作，反复监测，成本较低，解决目前胃肠道上皮屏障功能异常早期诊断和监测的临床需求。Aiming at the deficiencies of the prior art, the present invention provides a device for measuring and evaluating the electrical impedance of the gastrointestinal mucosal epithelium, which combines impedance measurement with an endoscope. Barrier assessment, and can be operated in real time, repeated monitoring, low cost, to solve the current clinical needs of early diagnosis and monitoring of abnormal gastrointestinal epithelial barrier function.
(二)技术方案(2) Technical solutions
为解决上述技术问题，本发明提供如下技术方案：一种胃肠道黏膜上皮电阻抗测量评估装置，包括套管和阻抗检测管，所述套管内设有检测通道，所述套管顶端为先端部，所述先端部上设有内窥镜和检测孔，所述检测孔为所述检测通道在所述先端部上的出口，所述套管中段设有调节器和行程测量盒，所述调节器上设有检测通道开口，所述检测通道开口与所述套管内的所述检测通道连通，所述阻抗检测管端部设有阻抗传感器，所述阻抗传感器从所述调节器上的所述检测通道开口穿入，通过所述套管内的所述检测通道从所述先端部上的所述检测孔穿出，所述套管穿过所述行程测量盒内部，并通过设在所述套管上的连接器伸出所述行程测量盒外与直线位移传感器连接，所述套管末端设有套管盒，多余的所述套管卷入所述套管盒放置，需要时拉出，所述套管穿过所述套管盒，所述套管与所述阻抗传感器通过数据传输线与处理器和显示器电连接。所述内窥镜通过套管与数据传输线电连接，所述内窥镜和所述阻抗传感器所检测的图像和数据通过所述数据传输线传输至处理器，经过所述处理器处理后传输至所述显示器显示，所述调节器可以用来调节所述套管插入病人胃肠内的方向和深度，方便全方位观察病人的胃肠内部。所述调节器设在所述行程测量盒之前，所述调节器上设有开关，所述开关与所述阻抗传感器、所述直线位移传感器和所述处理器电连接，所述处理器与所述内窥镜、所述显示器和电源连接。In order to solve the above-mentioned technical problems, the present invention provides the following technical solutions: a gastrointestinal mucosal epithelial electrical impedance measurement and evaluation device, comprising a sleeve and an impedance detection tube, wherein a detection channel is provided in the sleeve, and the top of the sleeve is an apex The front end is provided with an endoscope and a detection hole, the detection hole is the outlet of the detection channel on the front end, and the middle section of the sleeve is provided with a regulator and a stroke measurement box. A detection channel opening is provided on the regulator, the detection channel opening communicates with the detection channel in the sleeve, and an impedance sensor is provided at the end of the impedance detection tube, and the impedance sensor is connected from all the holes on the regulator. The detection channel opening is penetrated, and the detection channel in the sleeve passes through the detection hole on the front end portion, the sleeve passes through the inside of the stroke measurement box, and passes through the detection channel provided in the The connector on the sleeve extends out of the stroke measurement box to connect with the linear displacement sensor, the end of the sleeve is provided with a sleeve box, and the redundant sleeve is rolled into the sleeve box and placed, and pulled out when necessary , the sleeve passes through the sleeve box, and the sleeve and the impedance sensor are electrically connected to the processor and the display through a data transmission line. The endoscope is electrically connected with the data transmission line through the sleeve, and the images and data detected by the endoscope and the impedance sensor are transmitted to the processor through the data transmission line, and then transmitted to the processor after being processed by the processor. The display shows that the regulator can be used to adjust the direction and depth of inserting the cannula into the stomach of the patient, so as to observe the interior of the stomach of the patient in an all-round way. The regulator is arranged before the stroke measurement box, and a switch is provided on the regulator, and the switch is electrically connected with the impedance sensor, the linear displacement sensor and the processor, and the processor is connected with the The endoscope, the display and the power supply are connected.
使用本发明提供的一种胃肠道黏膜上皮电阻抗测量评估装置时，将所述套管插入病人食管，将所述阻抗检测管及所述阻抗检测管端部的所述阻抗传感器从所述调节器上的检测通道开口插入所述套管内的所述检测通道，使所述阻抗传感器从所述套管的先端部上的检测孔伸出，通过所述内窥镜观察所述阻抗传感器在病人体内的位置，当所述内窥镜在到达病人胃肠部贲门位置时，按下所述开关，所述阻抗传感器和所述直线位移传感器开始工作，记录数据，并通过所述数据传输线将数据传输至所述处理器进行处理，所述显示器显示所述内窥镜观察到的图像，所述显示器另外还显示所述阻抗传感器检测到的上皮电阻抗数据和所述直线位移传感器检测到的所述套管在病人胃肠部的插入深度，得到病人胃肠部上皮电阻抗值随所述套管插入深度变化的波形数据，医护人员可以通过所述显示器显示的图像和波形数据，判断病人胃肠部上皮电阻抗的异常位置，从而进行针对性诊断和治疗。When using the gastrointestinal mucosal epithelial electrical impedance measurement and evaluation device provided by the present invention, the cannula is inserted into the patient's esophagus, and the impedance detection tube and the impedance sensor at the end of the impedance detection tube are removed from the The detection channel opening on the regulator is inserted into the detection channel in the sleeve, so that the impedance sensor protrudes from the detection hole on the front end of the sleeve, and the impedance sensor is observed through the endoscope. The position in the patient's body, when the endoscope reaches the position of the gastrointestinal cardia of the patient, press the switch, the impedance sensor and the linear displacement sensor start to work, record data, and transmit the data through the data transmission line. The data is transmitted to the processor for processing, the display displays the image observed by the endoscope, and the display additionally displays the epithelial electrical impedance data detected by the impedance sensor and the linear displacement sensor detected. The insertion depth of the cannula in the patient's gastrointestinal tract can obtain the waveform data of the epithelial electrical impedance value of the patient's gastrointestinal tract changing with the cannula insertion depth. The medical staff can judge the patient through the images and waveform data displayed on the display. Abnormal location of gastrointestinal epithelial electrical impedance for targeted diagnosis and treatment.
进一步地，所述行程测量盒上设有行程槽，所述连接器在行程槽内滑动，所述行程槽的长度大于所述直线位移传感器的最大测量行程。在所述套管插入病人胃肠部过程中，所述连接器随着所述套管移动，通过所述直线位移传感器可以检测所述连接器的移动距离，从而得出所述套管在病人体内的插入深度，所述行程槽的长度大于所述直线位移传感器的最大测量行程，保证所述直线位移传感器能测量所述套管的全部行程。Further, the travel measuring box is provided with a travel groove, the connector slides in the travel groove, and the length of the travel groove is greater than the maximum measurement travel of the linear displacement sensor. During the process of inserting the cannula into the stomach of the patient, the connector moves with the cannula, and the linear displacement sensor can detect the moving distance of the connector, so that it can be concluded that the cannula is in the patient's stomach. The insertion depth in the body and the length of the stroke groove are greater than the maximum measuring stroke of the linear displacement sensor to ensure that the linear displacement sensor can measure the entire stroke of the sleeve.
进一步地，所述直线位移传感器的最大测量行程大于600mm。由于成人胃肠部长度一般不大于550mm，所述直线位移传感器的最大测量行程应大于一般成人的胃肠部长度，保证所述套管可以测量整个胃肠部，满足测量需求。Further, the maximum measuring stroke of the linear displacement sensor is greater than 600mm. Since the length of the gastrointestinal tract of an adult is generally not greater than 550mm, the maximum measurement stroke of the linear displacement sensor should be greater than the length of the gastrointestinal tract of a general adult, so as to ensure that the sleeve can measure the entire gastrointestinal tract and meet the measurement requirements.
进一步地，所述套管为柔性套管，所述套管在所述调节器之前的长度大于1000mm。采用柔性套管可以保证所述套管在病人体内的转向方便，便于测量胃肠部的各个不同位置，同时避免造成病人不适。Further, the sleeve is a flexible sleeve, and the length of the sleeve before the adjuster is greater than 1000 mm. The use of the flexible sleeve can ensure that the sleeve can be easily turned in the patient's body, facilitate the measurement of various positions of the gastrointestinal tract, and avoid discomfort to the patient.
进一步地，所述阻抗传感器伸出所述检测孔距离不少于5mm，通过所述内窥镜可以观察所述阻抗传感器的头部位置。采用这种布置方式可以保证所述内窥镜在病人胃肠道时，时刻能够观察到所述阻抗传感器的测量位置，方便医护人员操作，同时也可以根据所述内窥镜的显示图像和所述阻抗传感器的测量数据综合判断病人胃肠道功能是否正常。Further, the distance of the impedance sensor extending out of the detection hole is not less than 5 mm, and the head position of the impedance sensor can be observed through the endoscope. This arrangement can ensure that the endoscope can always observe the measurement position of the impedance sensor when it is in the patient's gastrointestinal tract, which is convenient for medical staff to operate. The measurement data of the impedance sensor is used to comprehensively judge whether the patient's gastrointestinal tract function is normal.
进一步地，所述套管盒内可伸出套管的长度大于1000mm。保证所述套管有足够的可伸出长度，便于医护人员操作。Further, the length of the sleeve that can protrude from the sleeve box is greater than 1000 mm. It is ensured that the cannula has a sufficient extendable length, which is convenient for medical staff to operate.
进一步地，所述阻抗传感器为有源式生物电阻抗传感器。有源式生物电阻抗传感器测量精度更加灵敏，更加适用于测量人体等生物的上皮电阻抗。Further, the impedance sensor is an active bioelectrical impedance sensor. The measurement accuracy of the active bioelectrical impedance sensor is more sensitive, and it is more suitable for measuring the epithelial electrical impedance of the human body and other organisms.
(三)有益效果：(3) Beneficial effects:
相对于现有技术，本发明产生的有益效果是：将阻抗传感器作为内镜的附件，和胃肠道内镜操作结合，在内镜操作的同时，简单方便地对胃肠道黏膜上皮屏障进行评估，医护人员可以通过测量图像和数据，综合判断病人胃肠道上皮电阻抗的异常位置，从而进行针对性诊断和治疗。且可以实时操作，反复监测，成本较低，有效解决了胃肠道上皮屏障功能异常早期诊断和监测的临床需求。Compared with the prior art, the beneficial effect of the present invention is: the impedance sensor is used as an accessory of the endoscope, combined with the operation of the gastrointestinal endoscope, and at the same time of the endoscope operation, the gastrointestinal mucosal epithelial barrier is simply and conveniently performed. Evaluation, medical staff can comprehensively judge the abnormal location of the patient's gastrointestinal epithelial electrical impedance by measuring images and data, so as to carry out targeted diagnosis and treatment. And it can be operated in real time, repeatedly monitored, and the cost is low, which effectively solves the clinical needs of early diagnosis and monitoring of abnormal gastrointestinal epithelial barrier function.
附图说明：Description of drawings:
为了更清楚地说明本发明实施例中的技术方案，下面将对实施例中所需要使用的附图作简单地介绍。In order to describe the technical solutions in the embodiments of the present invention more clearly, the accompanying drawings required in the embodiments will be briefly introduced below.
图1是根据本发明实施例所述的胃肠道黏膜上皮电阻抗测量评估装置的结构示意图；1 is a schematic structural diagram of a device for measuring and evaluating electrical impedance of gastrointestinal mucosal epithelium according to an embodiment of the present invention;
图2是根据本发明实施例所述的胃肠道黏膜上皮电阻抗测量评估装置的控制原理图；Fig. 2 is a control principle diagram of a device for measuring and evaluating electrical impedance of gastrointestinal mucosal epithelium according to an embodiment of the present invention;
图3是根据本发明实施例所述的胃肠道黏膜上皮电阻抗测量评估装置的所述先端部的局部放大示意图；3 is a partially enlarged schematic view of the tip portion of the device for measuring and evaluating the electrical impedance of gastrointestinal mucosal epithelium according to an embodiment of the present invention;
图中：1、阻抗检测管；11、阻抗传感器；2、套管；21、检测通道；22、先端部；23、内窥镜；24、检测孔；3、检测通道开口；4、调节器；5、开关；6、行程测量盒；7、连接器；8、直线位移传感器；9、套管盒；10、数据传输线；11、显示器；12、处理器；13、电源；14、行程槽In the figure: 1. Impedance detection tube; 11. Impedance sensor; 2. Cannula; 21. Detection channel; 22. Tip; 23. Endoscope; 24. Detection hole; 3. Detection channel opening; 4. Regulator ;5, switch; 6, stroke measuring box; 7, connector; 8, linear displacement sensor; 9, casing box; 10, data transmission line; 11, display; 12, processor; 13, power supply; 14, stroke groove
具体实施方式：Detailed ways:
下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述。The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention.
参照图1、图2和图3所示，一种胃肠道黏膜上皮电阻抗测量评估装置，包括套管2和阻抗检测管1，套管2内设有检测通道21，套管2顶端为先端部22，先端部22上设有内窥镜23和检测孔24，检测孔24为检测通道21在先端部22上的出口，套管2中段设有调节器4和行程测量盒6，调节器4上设有检测通道开口3，检测通道开口3与套管2内的检测通道21连通，阻抗检测管1端部设有阻抗传感器11，阻抗传感器11从调节器4上的检测通道开口3穿入，通过套管2内的检测通道21从先端部22上的检测孔24穿出，套管2穿过行程测量盒6内部，并通过设在套管2上的连接器7伸出行程测量盒6外与直线位移传感器8连接，套管2末端设有套管盒9，多余的套管2卷入套管盒9放置，需要时拉出，套管2穿过所述套管盒9，套管2与阻抗传感器11通过数据传输线10与处理器12和显示器11电连接。内窥镜23通过套管2与数据传输线10电连接，内窥镜23和阻抗传感器11所检测的图像和数据通过数据传输线10传输至处理器12，经过处理器12处理后传输至显示器11显示，调节器4可以用来调节套管2插入病人胃肠内的方向和深度，方便全方位观察病人的胃肠内部。调节器4设在行程测量盒6之前，调节器4上设有开关5，开关5与阻抗传感器11、直线位移传感器8和处理器12电连接，处理器12与内窥镜23、显示器11和电源13连接。Referring to Fig. 1, Fig. 2 and Fig. 3, a gastrointestinal mucosal epithelial electrical impedance measurement and evaluation device comprises a
优选地，行程测量盒6上设有行程槽14，连接器7在行程槽14内滑动，行程槽14的长度大于直线位移传感器8的最大测量行程。在套管2插入病人胃肠部过程中，连接器7随着套管2移动，通过直线位移传感器8可以检测连接器7的移动距离，从而得出套管2在病人体内的插入深度，行程槽14的长度大于直线位移传感器8的最大测量行程，保证直线位移传感器8能测量套管2的全部行程。Preferably, the travel measuring box 6 is provided with a travel groove 14 , and the connector 7 slides in the travel groove 14 , and the length of the travel groove 14 is greater than the maximum measurement travel of the
优选地，直线位移传感器8的最大测量行程大于600mm。由于成人胃肠部长度一般不大于550mm，直线位移传感器8的最大测量行程应大于一般成人的胃肠部长度，保证套管2可以测量整个胃肠部，满足测量需求。Preferably, the maximum measuring stroke of the
优选地，套管2为柔性套管，套管2在调节器4之前的长度大于1000mm。采用柔性套管可以保证套管2在病人体内的转向方便，便于测量胃肠部的各个不同位置，同时避免造成病人不适。Preferably, the
优选地，阻抗传感器11伸出检测孔24距离不少于5mm，通过内窥镜23可以观察阻抗传感器11的头部位置。采用这种布置方式可以保证内窥镜23在病人胃肠部时，时刻能够观察到阻抗传感器11的测量位置，方便医护人员操作，同时也可以根据内窥镜23的显示图像和阻抗传感器11的测量数据综合判断病人胃肠道功能是否正常。Preferably, the
优选地，套管盒9内可伸出套管2的长度大于1000mm。保证套管2有足够的可伸出长度，便于医护人员操作。Preferably, the length of the
优选地，阻抗传感器11为有源式生物电阻抗传感器。有源式生物电阻抗传感器测量精度更加灵敏，更加适用于测量人体等生物的上皮电阻抗。Preferably, the
本发明的工作原理是：The working principle of the present invention is:
使用本发明提供的一种胃肠道黏膜上皮电阻抗测量评估装置时，将套管2插入病人食管，将阻抗检测管1及阻抗检测管1端部的阻抗传感器11从调节器4上的检测通道开口3插入套管2内的检测通道21，使阻抗传感器11从套管2的先端部22上的检测孔24伸出，通过内窥镜23观察阻抗传感器11在病人体内的位置，当内窥镜23在到达病人胃肠部贲门位置时，按下开关5，阻抗传感器11和直线位移传感器8开始工作，记录数据，并通过数据传输线10将数据传输至处理器12进行处理，显示器11显示内窥镜23观察到的图像，显示器11另外还显示阻抗传感器11检测到的上皮电阻抗数据和直线位移传感器8检测到的套管2在病人胃肠部的插入深度，得到病人胃肠部黏膜上皮电阻抗值随套管2插入深度变化的波形数据，医护人员可以通过显示器11显示的图像和波形数据，判断病人胃肠部黏膜上皮电阻抗的异常位置，从而进行针对性诊断和治疗。When using the gastrointestinal mucosal epithelial electrical impedance measurement and evaluation device provided by the present invention, insert the
上面以举例方式对本发明进行了说明，但本发明不限于上述具体实施例，凡基于本发明所做的任何改动或变型均属于本发明要求保护的范围。The present invention is described above by way of example, but the present invention is not limited to the above-mentioned specific embodiments, and any changes or modifications made based on the present invention belong to the scope of protection of the present invention.
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