CN111514091A

CN111514091A - Whitening, freckle-removing and anti-aging face cream and preparation method thereof

Info

Publication number: CN111514091A
Application number: CN202010361067.3A
Authority: CN
Inventors: 刘科勇
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-04-30
Filing date: 2020-04-30
Publication date: 2020-08-11

Abstract

The invention discloses a whitening, freckle-removing and anti-aging cream and a preparation method thereof, wherein the cream comprises moisturizing components, whitening and freckle-removing components and skin tightening components; the moisture-keeping and moistening component comprises at least one of tea extract, sturgeon caviar extract, fucus extract and collagen; the whitening and freckle-removing component comprises at least one of lactoferrin, glycyrrhiza glabra, arbutin, vitamin C inducer and vitamin C; the skin tightening component comprises a peptide. The facial cream disclosed by the invention can reduce the generation of expression lines, after entering into skin dermal tissues, the facial cream promotes the synthesis of collagen, increases elastic fibers and hyaluronic acid, keeps the water content of skin, enables muscle cells to be always in a full and plump state, fills fine lines, restores elasticity, improves the structure and function of the skin, improves the metabolism of the skin through the matching of various components, and enables the skin to restore a young state.

Description

Whitening, freckle-removing and anti-aging face cream and preparation method thereof

Technical Field

The invention relates to the technical field of skin care products, in particular to a whitening, freckle-removing and anti-aging face cream and a preparation method thereof.

Background

At present, in order to lighten spots, remove wrinkles and whiten skin, only cosmetics and concealer products are used for whitening skin, but the skin is covered, and the surface is good but not treated. For facial skin, the cream is often applied in the morning and evening to replenish and lock water. The existing face creams are divided into a plurality of types, and have the functions of moisturizing, whitening and removing freckles and the function of resisting aging, but the existing face cream products cannot simultaneously realize various effects of moisturizing, whitening, skin tightening and resisting aging.

At present, most of skin moisturizing, whitening or freckle removing face creams mainly aim at a rate-limiting enzyme (tyrosinase) for melanin generation, inhibit tyrosinase activity or block an oxidation path of melanin generated by tyrosine, so that melanin generation is reduced, and the skin whitening effect is achieved. The functional raw materials added in the whitening cream sold on the market at present mainly comprise cell growth factors, animal placenta extract, kojic acid, hydroquinone and the like, and the components with the whitening effect can cause certain damage to skin, so that the product is easy to generate the phenomena of color change, smell change, instability and short storage life. For example, the activity of cell growth factors and animal placenta extracts has short shelf life, is not easy to store for a long time, and is easy to cause discoloration and off-flavor; when the addition amount of kojic acid reaches a certain degree, contact dermatitis is easily caused; the pure chemical substances have good whitening effect, but have large side effect and are easy to hurt the skin; the pure natural plant extract has small side effect, but the active ingredients are difficult to be absorbed by the skin of the body and are easy to be covered by other substances, and the whitening effect cannot be fully exerted, so the effect is not ideal.

The skin structure is divided into epidermis and dermis; the epidermis is stacked in a layered structure and is positioned on the skin surface, and the epidermis layer can be divided into five layers. Base layer: i.e., the basal cell layer, is the lowest layer of the epidermis. The basal layer is a layer of cells with the strongest division and proliferation capacity in the epidermis, 30-50% of basal cells carry out nuclear division every day, the division cycle is about twenty days, and the generated new cells move upwards to enter the spinous layer, so the basal layer is also called as a germinal layer. The cells proliferating in the basal layer gradually move toward the epidermal layer and gradually differentiate into other layers. In the process of healing skin wounds, basal layer cells have important regeneration and repair functions. A spinous layer: the basal layer is composed of 4-10 layers of polygonal and large-volume spinous layer cells, and has division and proliferation capacity, but is limited to cells in the deep layer close to the basal layer. The cells in the deep part of the spinous layer are polygonal and flat as the depth of the spinous layer is increased. A particle layer: it is located in the superficial part of the spinous cell layer, usually in the epidermis of the palm and the foot, and has a cell thickness of up to 10 layers. It is also called the transition zone because it transitions between normal epidermal cells and dead keratinocytes. The 'membrane granules' in the cells on the upper part of the granular layer release phospholipid substances to the intercellular space, so that the adjacent cells are not easy to separate and become waterproof barriers, the body surface water is not easy to permeate, and the water in the body is prevented from permeating outwards. Transparent layer: is the prophase of the horny layer, consists of 2-3 layers of flat cells, has no nucleus and is only seen in the epidermis of the palm and the sole. HE dyeing is acidophilic, and the slices are bent in a wave-shaped band shape and have strong refractivity, so the film is named as a transparent layer. Has the barrier function of preventing water, electrolyte and chemical substances from passing through. On static electricity, the granular cell layer is a charge carrying negative charge band, and the transparent layer is a charge carrying positive charge band, which constitutes an important defense barrier of the epidermis. Horny layer: is the outermost layer of the epidermis, consisting of multiple layers of keratinocytes and stratum corneum lipids. The stratum corneum consists mainly of 5 to 10 flat, dead cells without nuclei, whereas the palmoplantar part can reach 40-50 layers. When these cells are shed, the cells in the underlying stratum basale are pushed up to form a new stratum corneum. This layer prevents water loss due to the formation of a sebum film. The normal water content of the horny layer is 20-25%, and when the water content of the horny layer is less than 10%, the horny layer can be dried and desquamated, and when the water content of the horny layer is less than 5%, the horny layer can be red, swollen, hot, painful and itchy. The cells, which are already keratinized, constitute the stratum corneum, which becomes dander after shedding. The germinal layer cells are continuously divided, and can supplement the desquamated cuticle. Under normal healthy conditions of the skin, there will be a metabolic cycle; pushing from inside to outside, the stroma blasts gradually grow and mature, finally become the stratum corneum and fall off; with the increase of age and the influence of external environment, the skin metabolism becomes slow, and metabolism difficulties of different degrees can occur; for example, if melanin metabolism is slowed down, pigmentation may appear and thus the melanin may evolve into spots; for example, water metabolism is too fast, which can cause water-oil imbalance; the stratum corneum metabolism is slow, so that the cutin can be slowly fallen off, the skin surface is rough, and the like.

The existing face cream product can only aim at solving a certain problem but cannot give consideration to various effects, such as comprehensive problems in various aspects of moisturizing, moistening, whitening, freckle removing, anti-aging, skin tightening and the like, and even if the existing commercially available product is declared to be capable of solving the problems in various aspects, the propaganda effect is difficult to achieve really and practically. Therefore, there is a need for a facial cream product that substantially moisturizes, whitens, removes freckles, resists aging, compacts the skin, maintains youthful facial skin, and does not damage the skin for long-term use.

Disclosure of Invention

Aiming at the problems in the prior art, the invention aims to provide a whitening, freckle-removing and anti-aging face cream.

The invention also aims to provide a preparation method of the whitening, freckle-removing and anti-aging cream.

Further, the invention also aims to provide application of the whitening, freckle-removing and anti-aging face cream.

The invention adopts the following technical scheme:

in certain embodiments, the whitening, freckle-removing and anti-aging cream comprises a moisturizing component, a whitening, freckle-removing component and a skin-tightening component; the moisture-keeping and moistening component comprises at least one of tea extract, sturgeon caviar extract, fucus extract and collagen; the whitening and freckle-removing component comprises at least one of lactoferrin, glycyrrhiza glabra, arbutin, vitamin C inducer and vitamin C; the skin tightening component comprises a peptide.

In certain embodiments, the moisturizing component comprises tea extract; the whitening and freckle-removing components comprise lactoferrin, glycyrrhiza glabra, arbutin, vitamin C inductor and vitamin C; the skin tightening component comprises a peptide.

Further, the cream comprises 1-30 parts of moisturizing and moisturizing components (such as 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29 or 30 parts of moisturizing and moisturizing components), 1-100 parts of freckle whitening components (such as 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 60, 70, 80, 90 or 100 parts of freckle whitening components), and 1-20 parts of skin whitening components (such as 1, 2, 3, 4, 5, 6, 7, 8, 11, 8, 10 parts of freckle whitening and whitening components), 12. 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 parts of a skin tightening ingredient).

In certain embodiments, the moisturizing component comprises 1-30 parts tea extract (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 parts tea extract); the whitening and freckle-removing component comprises 1-20 parts of lactoferrin (such as 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 parts of lactoferrin), 1-20 parts of glycyrrhiza glabra (such as 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 parts of glycyrrhiza glabra), 1-20 parts of arbutin (such as 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 parts of arbutin), 1-20 parts of vitamin C inducer (such as 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 parts of vitamin C inducer), and 1-20 parts of vitamin C inducer (such as 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or, 3. 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 parts of vitamin C); the skin tightening component comprises 1-20 parts of peptide (such as 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 parts of peptide).

The term "vitamin C inducer" as used herein is a derivative of vitamin C, which is conventionally commercially available, has a smaller molecular weight and is more easily absorbed. Generally, vitamin C inducer has high stability and is not easily oxidized by air.

Researchers have shown that vitamin C taken from the diet can be stored in humans at most 1200 mg, and only 9% of them can reach the skin, and thus the skin needs to be metabolized in the environment and consumed a lot of vitamin C are not sufficiently satisfied at all. Therefore, the vitamin C content in the skin can meet the requirements of inhibiting melanin and resisting free radicals by means of local application. Researches also find that the high-purity vitamin C under normal state is very unstable, is easy to oxidize and decompose, cannot be stored for a long time, and cannot ensure the using effect.

The term "vitamin C" as used herein is water-soluble (its aqueous solution is acidic) and is a strong antioxidant, but also protects other antioxidants, such as vitamin a, vitamin E, unsaturated fatty acids, from free radicals harmful to the human body. The strength of the vessel wall is strongly related to vitamin C, the microvessels are the smallest of all vessels, the wall may have a cell thickness, and the strength and elasticity are determined by collagen which is responsible for connecting cells and has a daubing effect. The presence of vitamin C helps the skin to maintain elasticity and vitality.

Enzymes are catalysts for biochemical reactions, and some enzymes require free sulfur groups (-SH) to remain active. Vitamin C can reduce disulfide bond (-S-S) to-SH, thereby improving activity of related enzyme and playing antioxidation role. The vitamin C, glutathione and-SH can form powerful antioxidant combination to eliminate free radical effectively, prevent lipid peroxidation and toxic action of some chemical matters and protect normal metabolism of skin cells. In addition, vitamin C can enhance chemotaxis and deformability of neutrophils, improve bactericidal ability, promote lymphoblast generation, improve recognition and killing of foreign and malignant cells, improve immunity of human body, and inhibit virus proliferation.

Preferably, vitamin C used in the present invention is vitamin C lyophilized powder, which is commercially available. The vitamin C freeze-dried powder ensures that the vitamin C is not oxidized in the processes of extraction and storage, and the antioxidant activity of the vitamin C freeze-dried powder is maintained to the maximum extent in the process of later use.

After the vitamin C inductor is matched with vitamin C and other active ingredients, the vitamin C inductor can realize the following effects: 1. active oxygen free radicals are removed, and skin aging is prevented; 2. promoting the generation of ceramide, wherein the ceramide is a colorless, transparent and liquid water-soluble lipid, can regularly regenerate keratin, promote cell metabolism and can transmit cell information; 3. inhibiting melanin generation, removing color spots, whitening skin, and removing speckle; 4. anti-inflammatory effect, acne removing, and sensitive skin repairing; 5. inhibiting and regulating sebum secretion, and shrinking pores; 6. increasing collagen of skin, and improving skin wrinkle and flabbiness; 7. promoting blood circulation and improving wrinkle.

Vitamin C has poor permeability and hardly penetrates the stratum corneum. If the anti-wrinkle effect is to be realized, a vitamin C inducer with strong permeability needs to be matched for use, then the vitamin C inducer can act on the dermis layer and reach the inside of the skin, the vitamin C can be restored through in-vivo enzyme decomposition, and acne removal and inflammation diminishing can be realized by matching with other active ingredients.

Collagen is the main component in skin, and accounts for more than 72% of the protein content in skin cells. The skin luster depends on the water content, and the collagen has good water retention capacity, so that the skin is moist, glossy and healthy.

Specifically, the tea extract is a Yunnan Pu' er tea extract. Generally, catechin compounds and abundant tea polyphenols in tea leaves have the effect of resisting aging of skin, and the tea leaf extract in the application mainly plays a moisturizing effect.

Further, the tea extract is prepared by the following steps:

(1) crushing tea leaves to obtain tea leaf powder of 100-500 meshes;

(2) adding the tea powder into an ethanol solution with the mass fraction of 40-70% (such as 40%, 50%, 60% or 70%), heating at room temperature at a rate of 1-3 ℃/min, wherein the temperature does not exceed 85 ℃ (if the temperature reaches 85 ℃, the temperature is maintained at the temperature), simultaneously performing microwave extraction with the microwave power of 500-1000W (such as 500W, 600W, 700W, 800W, 900W or 1000W), the extraction time of 20-30 min, filtering, and collecting the filtrate; optionally, the tea powder and the ethanol solution are mixed in a mass ratio of 1: 2-5, adding;

(3) concentrating the filtrate collected in step (2) by rotary concentration evaporator under pressure of 0.08-0.1 MPa and water bath temperature of 40-70 deg.C (e.g., 40 deg.C, 41 deg.C, 42 deg.C, 43 deg.C, 44 deg.C, 45 deg.C, 46 deg.C, 47 deg.C, 48 deg.C, 49 deg.C, 50 deg.C, 51 deg.C, 52 deg.C, 53 deg.C, 54 deg.C, 55 deg.C, 56 deg.C, 57 deg.C, 58 deg.C, 59 deg.C, 60 deg.C, 61 deg.C, 62 deg.C, 63 deg.C.

The term "sturgeon caviar extract" as used herein is an extract of roe of sturgeon, is a collagen enhancer and protein crosslinking inhibitor, and improves cell mitochondrial function, and it is rich in vitamins and minerals, and can nourish skin and reduce aging. In addition, it can relieve the symptoms of skin aging, including skin roughness, fine lines, wrinkles, sagging and hyperpigmentation, i.e., skin darkening, while it has the effect of keeping the skin moist. The sturgeon caviar extract in the present application, in conjunction with other ingredients, may improve mitochondrial function and thus help improve skin appearance at the cellular level and alleviate inflammatory symptoms around aging skin tissue cells.

The term "Fucus vesiculosus extract" as used herein is a brown alga grown on a rock on the shore, which has a dark brown alga body, is bifurcated, is a flat angular leaf, contains fucoidan sulfate, and is effective in scavenging superoxide anion radicals and hydroxyl radicals. The Fucus vesiculosus extract is prepared from Fucus vesiculosus in rock coast and saline-alkali beach of northern temperate zone. The Fucus vesiculosus extract can balance metabolism, improve immunity, supplement mineral substances, absorb arsenic, form metallothionein containing arsenic in cells, is rich in calcium element and iodine element, has effects of caring skin, delaying aging, moistening skin, whitening skin, removing speckle, and repairing damaged skin, and makes skin refreshing, smooth, bright and beautiful.

Considering the skin whitening and tightening effects of the product of the present application, it is desirable to add a suitable amount of lactoferrin, which in physiological concentrations not only promotes the proliferation and differentiation of primary osteoblasts, but also reduces the apoptosis of osteoblasts, has the effect of inhibiting the proliferation of osteoclasts, functions as a cell growth factor, and is easily absorbed.

The term "Glycyrrhiza glabra" as used herein is one of the glycyrrhiza uralensis, and the functional components with strong antioxidant activity for skin decolorization and color spot lightening exist in the tissue cells of roots and rhizomes of the glycyrrhiza glabra, mainly comprising the glycyrrhiza glabra and the glycyrrhiza glabra, and have strong antioxidant activity, tyrosinase activity inhibition, color spot lightening and whitening functions. The glabridin has good compatibility and compatibility with other components in the invention, and can not generate antagonistic reaction.

Further, the glycyrrhiza glabra is a glycyrrhiza glabra extract, and the glycyrrhiza glabra extract is prepared by the following steps:

(A) cleaning Glycyrrhiza glabra (mainly roots and stems), drying in the sun until the water content is 1-10%, and then crushing into 100-300 mesh (such as 100-200 mesh and 200-300 mesh) Glycyrrhiza glabra fine powder;

(B) adding the glycyrrhiza glabra fine powder into an ethanol solution with the mass fraction of 20-50% (such as 20%, 30%, 40% or 50%), heating at room temperature at a rate of 1-3 ℃/min, wherein the temperature is not more than 65 ℃ (if the temperature reaches 65 ℃, the temperature is maintained at the temperature), simultaneously performing microwave extraction, wherein the microwave power is 500-1000W (such as 500W, 600W, 700W, 800W, 900W or 1000W), the extraction time is 10-30 minutes, filtering, and collecting filtrate; optionally, the weight ratio of the glycyrrhiza glabra fine powder to the ethanol solution is 1: 2-5, adding;

(C) concentrating the filtrate collected in step (B) by rotary concentration evaporator under pressure of 0.08-0.1 MPa and water bath temperature of 40-60 deg.C (e.g., 40 deg.C, 41 deg.C, 42 deg.C, 43 deg.C, 44 deg.C, 45 deg.C, 46 deg.C, 47 deg.C, 48 deg.C, 49 deg.C, 50 deg.C, 51 deg.C, 52 deg.C, 53 deg.C, 54 deg.C, 55 deg.C, 56 deg.C, 57 deg.C, 58 deg.C, 59 deg.C or 60.

Glycyrrhiza glabra L.extract also has effects of preventing pachylosis, resisting inflammation, resisting bacteria, scavenging oxygen free radical similar to SOD (superoxide dismutase), and resisting oxygen free radical similar to vitamin E.

The term "free radical" as used herein refers to an atom or group with an unpaired electron formed by homolytic cleavage of a covalent bond, including, but not limited to, the following: superoxide anion radical (O)₂ ^-) Hydrogen peroxide (H)₂O₂) Hydroxyl radical (. OH), monooxygen (C) ((II))¹O₂) Carbon-centered (. CH-R) lipid radicals or L. radicals, and the like. Free radicals in the human body are very reactive atoms or groups that can oxidize other substances in the human body.

The term "arbutin" as used herein, also known as arbutin, is white needle-like crystals or powder, and can inhibit the activity of tyrosinase in vivo and prevent the generation of melanin, thereby reducing skin pigmentation, removing stains and freckles, and also has antibacterial and anti-inflammatory effects.

Further, the peptide comprises at least one of a dipeptide, a tripeptide, a tetrapeptide, a pentapeptide, a hexapeptide, a heptapeptide, an octapeptide and a nonapeptide.

Further, the peptides comprise a tetrapeptide and a heptapeptide, and optionally, the weight ratio of the tetrapeptide to the heptapeptide is 1: 0.5 to 5, for example 1: 0.8,1: 1,1: 1.5,1: 2,1: 3,1: 4 or 1: 4.5, etc.

In the present application, the components of the peptides have compatible efficacy, specifically, in various embodiments, the ratio of the peptides: has effects in removing wrinkle, promoting collagen absorption and utilization, and relaxing muscle. The three peptides: can stimulate the generation of glucosamine polyacid and collagen, promote the growth of skin cells, and promote the healing and proliferation of wounds. Four peptides: can promote the proliferation of collagen, elastic fiber and hyaluronic acid, improve the water content of skin, increase the thickness of skin, reduce fine lines, resist aging, remove free radicals, repair damaged skin, and rejoin broken muscle layer fiber. Five peptides: can directly act on the dermis to promote the proliferation of collagen, elastic fiber and hyaluronic acid, achieve the purpose of skin tightening, improve the water content of the skin, and accelerate the tightening and lifting effects by matching with other moisturizing components. The peptide has the following components: inhibit excessive release of nerve substances, influence the function of transfer protein between subcutaneous nerve and muscle, and reduce the generation of dynamic lines such as expression lines and wrinkles. Heptapeptide: the muscles are relaxed, and the effects of smoothing dynamic lines, static lines and fine lines are achieved. The eight peptides: promoting proliferation of glycosaminoglycan and fibronectin, reducing fine wrinkles, relieving edema, improving microcirculation, promoting blood circulation, and relieving inflammation. Nine peptides: blocking and stopping the conduction of alpha-melanocyte stimulating hormone message at the source of melanogenesis, and avoiding the combination with the receptor on melanocyte, so as to reduce the chance of melanogenesis.

Further, the peptide is a peptide doped with platinum and/or gold.

Further, the particle size of the platinum and/or gold is 1-500 nm, such as 1-10 nm, 10-50 nm, 50-100 nm, 100-150 nm, 150-200 nm, 200-250 nm, 250-300 nm, 300-350 nm, 350-400 nm, 400-450 nm or 450-500 nm. Because the platinum and/or gold particles are very fine, the nano platinum and/or gold particles can be easily brought to subcutaneous tissues through capillaries, and the wrinkle-preventing and moisturizing cream has obvious effects on wrinkle prevention and moisture preservation. Pure platinum and/or gold has the same electric wave length with human body, promotes the flow of ions in the tissue, makes the blood circulation good, thus makes the metabolism in the body better, and makes the viscera and skin tissues activated from the inside of the body, which is called the activation of pure gold. The peptide doped with platinum and/or gold can generate a thermal conductor when being smeared on the surface of the skin, and can play a synergistic action with other active ingredients, promote blood circulation, accelerate the elimination of cytotoxin, ensure healthy metabolism and growth of the skin, and ensure that the skin becomes tender, moist and young.

Platinum and/or gold peptide are doped in the skin care cream, so that side effects are avoided, negative ions are released by the gold to activate the regeneration capacity of skin collagen, free radicals are resisted, two anti-wrinkle components of the gold and the peptide are mutually excited, the gold negative ions with a local micro electric field have strong leading-in capacity, the gold negative ions are used as a carrier to carry peptide wrinkle-removing groups with strong wrinkle-removing capacity to permeate into a skin substrate, essence or active ingredients are rapidly led in, and the anti-wrinkle effect is synergistically generated. The peptide doped with platinum and/or gold has a sarcoid texture, locally blocks nerve transmission muscle contraction information, influences the skin-soil nerve conduction, relaxes facial muscles, smoothes dynamic lines, static lines and fine lines, and is particularly suitable for the parts (faces and forehead) with concentrated expression muscles.

The peptide doped with platinum and/or gold in the application can promote the growth of collagen, prevent the relaxation and fine lines caused by the loss of skin collagen, support the cells by the collagen which promotes the growth, form the plumpness of the skin, further fill the shriveled skin of the wrinkles, and achieve the effects of preventing and removing the wrinkles. In addition, the platinum and/or gold particles which are doped into the skin can improve the permeability, create a good introduction environment, enable the skin to better absorb nutrient components, enable the skin to be shinier and fuller, and the platinum and/or gold particles which are subjected to micro-treatment can penetrate into the deeper layer of the skin, strengthen the immune system of skin cells and have the effect of tensioning aged skin. The peptide doped with platinum and/or gold can not only eliminate vivotoxin, but also be a substance capable of promoting skin cell regeneration, can improve skin color, promote blood circulation, activate cells, and has auxiliary effects in spot fading, scar treatment, pox treatment and the like.

Preferably, the peptides comprise a platinum-doped tetrapeptide and a gold-doped heptapeptide, and optionally, the weight ratio of the platinum-doped tetrapeptide to the gold-doped heptapeptide is 1: 0.5 to 5, for example 1: 0.8,1: 1,1: 1.5,1: 2,1: 3,1: 4 or 1: 4.5, etc.

Further, platinum and/or gold may be incorporated in an amount of 0.00001% to 0.1%, for example 0.00001%, 0.00003%, 0.00006%, 0.00009%, 0.00012%, 0.00015%, 0.00018%, 0.0002%, 0.0003%, 0.0004%, 0.0005%, 0.0006%, 0.0007%, 0.0008%, 0.0009% or 0.001%, or 0.001% to 0.01%, 0.01% to 0.1% by weight of the peptide.

Further, the cream does not contain preservatives.

In various embodiments, the creams of the present application are free of (chemically synthesized) preservatives such as, by way of example: benzoic acid and salts thereof, sorbic acid and salts thereof, dehydroacetic acid and salts thereof, parabens, and the like, and specifically, for example, methylparaben, propylparaben, phenoxyethanol, benzyl alcohol, phenethyl alcohol, bis (hydroxymethyl) imidazolidinyl urea, potassium sorbate, sodium benzoate, chlorphenesin, sodium dehydroacetate, and the like.

Further, the cream does not contain or is not added with dioxane, silicone oil (polydimethylsiloxane), sodium lauryl sulfate, sodium laureth sulfate, sodium trideceth sulfate, ammonium lauryl sulfate, ammonium laureth sulfate, styrene-acrylamide copolymer, diethanolamide coconut oil, monoethanolamide coconut oil, cetearyl olivinoleate, polysorbate-60, polysorbate-80, sorbitan olivinoleate, methylgluco sesquistearate, PEG-20 methylgluco sesquistearate, PEG-40 hydrogenated castor oil, PPG-26-butanolpolyether-26, PEG-4 polyglycerol-2 stearate, PEG-60 hydrogenated castor oil, steareth-2, steareth-21, polysorbitol, sodium lauryl sulfate, sodium laureth sulfate, trideceth sulfate, sodium trideceth sulfate, ammonium laureth sulfate, styrene-acrylamide copolymer, coco oleic diethanolamide, coconut monoethanolamide, cetearyl oleate, polysorbate-60, polysorbate, PPG-13-decyltetradecyltetraeth-24, cetearyl glucoside, PEG-100 stearate, glyceryl stearate, cocoyl glucoside, ceteareth-25, PEG-40 stearate, glyceryl stearate citrate, polyglyceryl-3-methylglucose distearate, polyglyceryl-10 stearate, polyglyceryl-10 myristate, polyglyceryl-10 dioleate, polyglyceryl-10 laurate, polyglyceryl-10 isostearate, polyglyceryl-10 oleate, polyglyceryl-10 diisostearate, polyglyceryl-6 laurate, polyglyceryl-6 myristate, sucrose stearate, sucrose polystearate, and the like.

The raw materials used in the present invention are generally commercially available unless otherwise specified.

A preparation method of a whitening, freckle-removing and anti-aging face cream comprises the following steps:

(a) mixing all the components in the moisturizing component to prepare the moisturizing component;

(b) mixing the components in the whitening and freckle-removing component to prepare the whitening and freckle-removing component;

(c) mixing the components of the skin firming component to prepare the skin firming component;

(d) mixing the components for moistening, whitening and removing speckle, and skin tightening.

Furthermore, the cream of the application can also contain 0-100 parts of water, and the water can be distilled water, deionized water, ultrapure water and the like, and preferably deionized water. The amount of water may be selected, for example, from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 60, 70, 80, 90, 100 parts.

Further, the cream of the present application may further comprise 0 to 20 parts of a natural thickener, for example, 0 (i.e., no natural thickener), 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 parts. The natural thickener comprises at least one of xanthan gum, arabic gum, guar gum, cassia gum, carrageenan, tara gum and seaweed gel.

The whitening, freckle-removing and anti-aging cream has the effects of moisturizing, whitening, freckle removing, skin tendering, wrinkle removing and anti-aging by being applied to human skin.

As used herein, "and/or" includes any and all combinations of one or more of the associated listed items. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It will be further understood that the terms "comprises" and/or "comprising," when used in this specification, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof.

Unless defined otherwise, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the relevant art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.

The exemplary invention described herein may suitably lack any one or more of the element limitations, which are not specifically disclosed herein. Thus, the terms "comprising," "including," "containing," and the like are to be construed broadly and in a non-limiting sense. Furthermore, the terms used herein are used as terms of description and not of limitation, and there is no intention in the use of such terms to describe only some of their characteristics but, in the light of the claims, various modifications are possible within the scope of the invention. Thus, while the present invention has been particularly disclosed in terms of preferred embodiments and optional features, modification of the invention herein disclosed to embody it may be noted by those skilled in the art, and such modifications and variations are considered to be within the scope of the invention.

Compared with the prior art, the invention has the beneficial effects that:

(1) the cream disclosed by the invention can resist skin sagging, promote skin compaction, remove free radicals, resist oxidation and carbonylation, protect collagen from being damaged by activated carbon groups, and promote repair of dermal tissues;

(2) the face cream disclosed by the invention is purely natural, does not contain preservatives, is safe and efficient, has no adverse stimulation and side effect on skin and human body, and can be used for a long time;

(3) the cream disclosed by the invention contains various anti-wrinkle peptide components, and can reduce the generation of expression lines, promote the generation of collagen and elastic fibers, resist free radicals, repair skin matrix, increase the elastic fibers and hyaluronic acid after entering skin dermal tissues, keep the water content of skin, enable muscle cells to be always in a full state, reduce the generation of dry lines, fine lines and expression lines, fill fine lines and restore elasticity, improve the structure and function of the skin, improve the metabolism of the skin and enable the skin to recover a young state through the matching of various components.

Detailed Description

For better explanation of the present invention, the following specific examples are further illustrated, but the present invention is not limited to the specific examples.

Example 1

A whitening, freckle-removing and anti-aging cream comprises a moisturizing component, a whitening and freckle-removing component and a skin-tightening component in parts by weight, wherein the moisturizing component comprises 1 part of Yunnan Pu' er tea extract; the whitening and freckle-removing component comprises 1 part of lactoferrin, 1 part of glycyrrhiza glabra, 1 part of arbutin, 1 part of vitamin C inducer and 5 parts of vitamin C; the skin tightening composition includes 1.6 parts peptide.

The peptide comprises the following components in a weight ratio of 1: 0.6 of tetrapeptide doped with platinum (0.0001 wt% of tetrapeptide) and heptapeptide doped with gold (0.0001 wt% of heptapeptide).

The Yunnan Pu' er tea extract is prepared by the following steps:

(1) crushing Yunnan Pu 'er tea leaves to obtain Yunnan Pu' er tea leaf powder of 200-400 meshes;

(2) adding the Yunnan Pu' er tea powder into an ethanol solution with the mass fraction of 55%, heating at room temperature at 3 ℃/min, and the temperature is not more than 85 ℃, simultaneously performing microwave extraction with the microwave power of 1000W and the extraction time of 30 minutes, then filtering, and collecting filtrate; optionally, the mass ratio of the Yunnan Pu' er tea powder to the ethanol solution is 1: 2, adding;

(3) concentrating the filtrate collected in the step (2) to paste by a rotary concentration evaporator under the pressure of 0.09MPa and the water bath temperature of 60 ℃ to obtain the Yunnan Pu' er tea extract.

The glycyrrhiza glabra is a glycyrrhiza glabra extract, and the glycyrrhiza glabra extract is prepared by the following steps:

(A) cleaning Glycyrrhiza glabra (mainly taking roots and stems), drying in the sun until the water content is 1-10%, and then crushing into 100-mesh 300-mesh Glycyrrhiza glabra fine powder;

(B) adding the fine powder of Glycyrrhiza glabra Linne into 40% ethanol solution, heating at room temperature at 2/min, and at a temperature not higher than 65 deg.C, simultaneously performing microwave extraction with microwave power of 1000W for 30 min, filtering, and collecting filtrate; mixing the glycyrrhiza glabra fine powder and an ethanol solution in a mass ratio of 1: adding in 3 lines;

(C) concentrating the filtrate collected in step (B) to paste by rotary concentration evaporator under pressure of 0.08MPa and water bath temperature of 55 deg.C to obtain Glycyrrhiza glabra extract.

Example 2

A whitening, freckle-removing and anti-aging cream comprises a moisturizing component, a whitening and freckle-removing component and a skin-tightening component in parts by weight, wherein the moisturizing component comprises 20 parts of Yunnan Pu' er tea extract; the whitening and freckle-removing component comprises 3 parts of lactoferrin, 5 parts of glycyrrhiza glabra, 6 parts of arbutin, 4 parts of vitamin C inducer and 10 parts of vitamin C; the skin tightening component comprises 10 parts of peptide and a proper amount of water.

The peptide comprises the following components in a weight ratio of 1: 1 with platinum (0.0002 wt% of the tetrapeptide) and heptapeptide with gold (0.0005 wt% of the heptapeptide).

The processing method of the Yunnan Pu-erh tea extract and the Glycyrrhiza glabra is the same as that of the example 1.

Example 3

The whitening, freckle-removing and anti-aging cream comprises a moisturizing component, a whitening and freckle-removing component and a skin-tightening component in parts by weight, wherein the moisturizing component comprises 25 parts of Yunnan Pu' er tea extract; the whitening and freckle-removing component comprises 6 parts of lactoferrin, 10 parts of glycyrrhiza glabra, 7 parts of arbutin, 10 parts of vitamin C inducer and 8 parts of vitamin C; the skin tightening component comprises 6 parts of peptide and a proper amount of water.

The peptide comprises the following components in a weight ratio of 1: 2 four peptide doped with platinum (0.00005 wt% of four peptide) and seven peptide doped with gold (0.00008 wt% of seven peptide).

Example 4

A whitening, freckle-removing and anti-aging cream comprises moisturizing, freckle-removing and skin-tightening components in parts by weight, wherein the moisturizing components comprise 30 parts of Yunnan Pu' er tea extract; the whitening and freckle-removing component comprises 6 parts of lactoferrin, 2 parts of glycyrrhiza glabra, 5 parts of arbutin, 8 parts of vitamin C inducer and 12 parts of vitamin C; the skin tightening component comprises 5 parts of peptide and a proper amount of water.

The peptide comprises the following components in a weight ratio of 1: 4 four peptide doped with platinum (0.00001 wt% of four peptide) and seven peptide doped with gold (0.0005 wt% of seven peptide).

Comparative example 1

The composition of comparative example 1 contained no vitamin C inducer, and the rest was the same as in example 2.

Comparative example 2

The composition of comparative example 2 contained no peptide, and was otherwise the same as in example 2.

Comparative example 3

The peptides in the composition of comparative example 3 were not incorporated in platinum or gold, and were otherwise identical to those in example 2.

And (3) evaluating the product effect: 140 volunteers (70 male, 70 female, age 25-40) were selected, and problems of blotchy face, pigmentation, dark yellow skin, etc. were noted. Volunteers were divided into 7 groups of 20 persons each, with 50% of each male and female proportion. First, trial the product of example 1; second, trial the product of example 2; the third group, trial example 3 product, the fourth group, trial example 4 product, the fifth group, trial comparative example 1 product, the sixth group, trial comparative example 2 product, the seventh group, trial comparative example 3 product.

The using method comprises the following steps: after the face is cleaned in the morning and evening, 3g of the product is uniformly applied to the face, gently patted for absorption, gently massaged for 3-5 minutes, and fully absorbed by the skin, and the face is continuously tried for 8 weeks. By means of the questionnaire form, subjective evaluation of a test person on the used product is investigated, and the subjective evaluation comprises indexes such as moisturizing effect, whitening and freckle removing effect, wrinkle removing effect and the like. The results are shown in Table 1.

Table 1: the results of the protective cream used in the examples and comparative examples.

As can be seen from table 1, examples 1 to 4 of the present invention have significant moisturizing effect, whitening and spot removing effect, compared to comparative examples.

Skin wrinkle removal test: the wrinkle-removing effects of examples 1 to 4 and comparative examples 1 to 3 were observed directly with naked eyes. The skin texture of the volunteers who used the creams of examples 1-4 became significantly fine, fine lines decreased, wrinkles became lighter, and the skin was glossy. While the skin texture of the volunteers using the creams of comparative examples 1-3 did not change and the number of fine lines slightly decreased.

Eye skin elasticity test: the facial skin elasticity was measured by a skin tester (MC750, CK, Germany) and the test results are given in Table 2. The greater the value of the skin elasticity parameter, the better the skin elasticity.

Table 2: examples and comparative examples test results for improving skin elasticity.

As can be seen from Table 2, after the wrinkle-removing cream prepared by the invention is used by a volunteer, the skin elasticity parameters are obviously improved, which shows that the wrinkle-removing cosmetic disclosed by the invention can increase the skin firmness and elasticity and improve the skin elasticity, and the vitamin C inducer, the peptide and the platinum or gold doped in the peptide have important influence.

The above description is only exemplary of the present invention and is not intended to limit the scope of the present invention, which is defined by the claims appended hereto, as well as the appended claims.

Claims

1. The whitening, freckle-removing and anti-aging cream is characterized by comprising moisturizing, whitening and freckle-removing components and skin-tightening components; the moisture-keeping and moistening component comprises at least one of tea extract, sturgeon caviar extract, fucus extract and collagen; the whitening and freckle-removing component comprises at least one of lactoferrin, glycyrrhiza glabra, arbutin, vitamin C inducer and vitamin C; the skin tightening component comprises a peptide.

2. The whitening, freckle-removing and anti-aging cream according to claim 1, wherein the cream comprises 1-30 parts of moisturizing ingredients, 1-100 parts of whitening and freckle-removing ingredients and 1-20 parts of skin tightening ingredients.

3. The whitening, freckle-removing and anti-aging cream according to claim 1, wherein the tea leaf extract is Yunnan Pu' er tea leaf extract.

4. The whitening, freckle-removing and anti-aging cream according to claim 1, wherein the tea extract is prepared by the following steps:

(1) crushing tea leaves to obtain tea leaf powder of 100-500 meshes;

(2) adding the tea powder into an ethanol solution with the mass fraction of 40-70%, heating at room temperature at the rate of 1-3 ℃/min, wherein the temperature does not exceed 85 ℃, simultaneously performing microwave extraction, wherein the microwave power is 500-1000W, the extraction time is 20-30 minutes, then filtering, and collecting filtrate;

(3) concentrating the filtrate collected in the step (2) to paste through a rotary concentration evaporator under the pressure of 0.08-0.1 MPa and the water bath temperature of 40-70 ℃ to obtain the tea extract.

5. The cream of claim 1, wherein the peptides comprise at least one of dipeptides, tripeptides, tetrapeptides, pentapeptides, hexapeptides, heptapeptides, octapeptides and nonapeptides.

6. The cream for whitening, removing freckles and resisting aging according to claim 1, characterized in that the peptide is a peptide doped with platinum and/or gold.

7. The whitening, freckle-removing and anti-aging cream according to claim 6, wherein the particle size of the doped platinum and/or gold is 1-500 nm.

8. The cream as claimed in claim 1, wherein the peptides comprise tetrapeptide doped with platinum and heptapeptide doped with gold.

9. The whitening, freckle-removing and anti-aging cream according to claim 1, wherein the platinum and/or gold is added in an amount of 0.00001-0.1% of the weight of the peptides.

10. The preparation method of the whitening, freckle-removing and anti-aging cream as claimed in any one of claims 1 to 9, which is characterized by comprising the following steps: