CN111494555A - A Chinese medicinal composition used as both medicine and food for improving immunity, and its preparation method - Google Patents
A Chinese medicinal composition used as both medicine and food for improving immunity, and its preparation method Download PDFInfo
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- CN111494555A CN111494555A CN202010408216.7A CN202010408216A CN111494555A CN 111494555 A CN111494555 A CN 111494555A CN 202010408216 A CN202010408216 A CN 202010408216A CN 111494555 A CN111494555 A CN 111494555A
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract
The invention relates to a medicine and food dual-purpose traditional Chinese medicine composition for improving human immunity, which comprises the following raw materials in parts by weight: 1.5-4.0 parts of dendrobium officinale, 1.0-3.0 parts of green tea extract and 0.5-1.5 parts of shiitake extract. In the components of the invention, the dendrobium officinale has the effects of nourishing yin and stomach, the green tea extract has the effects of clearing heat and removing toxicity, and the mushroom extract has the effects of tonifying spleen and regulating stomach and also has the effects of supporting pox and removing toxicity. The three components are rich in biological activities of improving immunity, resisting tumor, diminishing inflammation, inhibiting bacteria and the like. Especially lentinan, has long been the first-line drug for patients with tumors. The combination of the two drugs has the effects of nourishing yin, clearing heat, tonifying qi, regulating the middle warmer and detoxifying, so that the effect is better. The components of the prescription belong to the homology of medicine and food, and have the dual effects of medicine and food, thereby achieving the purposes of treating diseases and preventing diseases.
Description
Technical Field
The invention relates to the field of traditional Chinese medicines, in particular to a medicine and food dual-purpose traditional Chinese medicine composition for improving human immune function and a preparation method thereof.
Background
The low immune function is a pathological feature, and is mainly characterized in that a patient loses the abilities of resisting and preventing diseases due to erosion of external diseases and loses good protection on the regulation of the body function, so that a series of diseases occur.
Healthy qi stores internally and pathogenic qi cannot dry out. This is the basic understanding of TCM in the prevention and treatment of disease. Namely, the basic means of preventing the occurrence of diseases and promoting the recovery after diseases is achieved by improving the immunologic function of the human body.
In recent years, much attention has been paid to immunotherapy of tumors, and it has been a focus of attention in the field of tumor therapy.
The tumor immunotherapy is to apply immunological principle and method to raise the immunogenicity of tumor cell and the killing sensitivity to effector cell, excite and strengthen the antitumor immune response of body, and to infuse immune cell and effector molecule into host body to cooperate with body's immune system to kill tumor and inhibit tumor growth. In view of the remarkable curative effect and innovation of tumor immunotherapy, the tumor immunotherapy is judged as the most important scientific breakthrough in the year 2013 by the journal of science. The tumor immunotherapy is expected to become an innovation in the field of tumor therapy after surgery, chemotherapy, radiotherapy and targeted therapy.
The basic principles of tumor immunotherapy are two: firstly, immune response regulation (immune activation, immune stimulation, immune modification and the like); secondly, the immune-related cytokines are directly used. The basic idea is to use tumor antigen to stimulate the body's own immune protection mechanism in vivo, so as to achieve the effect of treating tumor or preventing recurrence. Actually, as early as over 100 years ago as the creation of immunology, scientists have proposed the idea of using the body's autoimmune function to attack tumor cells and destroy tumors, and have made various attempts. In the fifties of the twentieth century, Burnet and Thomas put forward the theory of "immune surveillance", and it is thought that mutated tumor cells which often appear in the body can be recognized and eliminated by the immune system, thereby laying the theoretical foundation for tumor immunotherapy. In 2003, a study published in the journal of new england medicine found that the number of tumor-infiltrating T cells correlated with the overall and progression-free survival of cervical cancer patients, confirmed the presence of tumor-specific T cells, indicating that the immune system is able to recognize tumors and attempt to control their growth. Immunity is a physiological function of the human body, and the human body recognizes "self" and "non-self" components by virtue of the function, thereby destroying and rejecting antigen substances (such as germs and the like) entering the human body, or damaged cells and tumor cells generated by the human body, and the like, so as to maintain the health of the human body. The concept of tumor immunotherapy has been highly concerned and appreciated, and is certainly a hopeful gospel for an increasing number of tumor patients.
In fact, regarding immunotherapy, it is by no means limited to the creation of immunology 100 years ago. As early as 2000, in the "emperor's internal classic of traditional Chinese medicine", there is a clear record of "healthy qi stores, and pathogens cannot be dried", and on this basis, a "strengthening healthy qi to eliminate pathogens" treatment rule with clinical characteristics of traditional Chinese medicine is established. Although the recognition of the characteristics of the obvious philosophy concept can not bring enough attention to modern medicine, the derived treatment principle of strengthening body resistance and eliminating pathogenic factors always guides the traditional Chinese medicine clinic in the history of thousands of years and is continuously verified by the science of the academic concept in the traditional Chinese medicine clinic. Strengthening body resistance and eliminating pathogenic factors to treat tumors is not a new discovery in traditional Chinese medicine clinical, and the key points are how to strengthen body resistance and how to eliminate pathogenic factors. In short, there is no confidence that the composition is "prescription and degree" in the clinical process.
Therefore, the traditional Chinese medicine composition which is safe to eat and the preparation method thereof are provided based on the principle of strengthening body resistance and eliminating pathogenic factors, and the application of the traditional Chinese medicine composition in enhancing the immunity of a tumor patient after operation is very significant for the tumor patient.
Disclosure of Invention
One object of the present invention is: provides a Chinese medicinal composition with safe eating for enhancing the immunity of a tumor patient after operation.
In order to achieve the above purpose, the invention provides the following technical scheme:
a medicine and food dual purpose traditional Chinese medicine composition for improving human immunity comprises the following raw materials in parts by weight: 1.5-4.0 parts of dendrobium officinale, 1.0-3.0 parts of green tea extract and 0.5-1.5 parts of shiitake extract.
Preferably, the medicine and food dual-purpose traditional Chinese medicine composition for improving human immunity comprises the following raw materials in parts by weight: 2.5 parts of dendrobium officinale, 2.0 parts of green tea extract and 1.0 part of shiitake extract.
Another object of the invention is: provides a preparation method of a traditional Chinese medicine composition which is safe to eat.
In order to achieve the above purpose, the invention provides the following technical scheme:
a preparation method of a medicine-food dual-purpose traditional Chinese medicine composition for improving human immunity comprises the following specific steps:
s1: cleaning Dendrobium officinale, soaking in warm water, decocting in water, and concentrating the decoction to obtain Dendrobium officinale concentrated solution;
s2, adding the green tea extract and the lentinus edodes extract into the dendrobium officinale concentrated solution, and fully and uniformly stirring;
s3, adding a flavoring agent into the product obtained in the step S2, and uniformly stirring to obtain a Chinese medicinal composition paste;
or adding flavoring agent and dextrin into the product obtained in step S2, drying at low temperature, and granulating to obtain Chinese medicinal composition granule;
or adding flavoring agent and dextrin into the product obtained in step S2, drying at low temperature, and tabletting to obtain Chinese medicinal composition tablet.
Preferably, the soaking temperature in step S1 is 45-65 deg.C, the soaking time is 2-5h, the decocting time with water is 2-3 times, and each time is 1-1.5 h.
Preferably, the concentration of the dendrobium officinale concentrated solution in the step S1 is 1.20-1.25 g/ml.
Preferably, the particle size of the green tea extract and the shiitake mushroom extract in step S2 is 120-150 mesh.
Preferably, in the step S3, the mass ratio of the product obtained in the step S2 to the flavoring agent in the Chinese medicinal composition paste is 15-20: 1-3.
Preferably, in step S3, in the Chinese medicinal composition granules, the mass ratio of the product of step S2, the flavoring agent and the dextrin is 15-20: 1-3: 2-6, and the low-temperature drying temperature is 40-50 ℃.
Preferably, in step S3, in the Chinese medicinal composition tablet, the mass ratio of the product of step S2, the flavoring agent and the dextrin is 15-20: 1-3: 2-6, and the low-temperature drying temperature is 40-50 ℃.
Preferably, in step S3, the flavoring agent is composed of sucrose, maltol and citric acid in a mass ratio of 2:1: 1.
The raw materials used in the traditional Chinese medicine composition are mainly introduced as follows:
dendrobe, also known as dendrobium nobile lindl rhyme, aleppo buergerianum, senecio cannabifolius, mangrove immortal plant, chlorophytum comosum, forest orchid, bansheng, dendrobium nobile, etc. Sweet in nature and slightly cold in taste. Has effects in nourishing stomach yin and promoting the production of body fluid, and is suitable for treating stomach yin deficiency syndrome such as heat disease body fluid injury, yin deficiency with internal heat, tongue light without fur, and little body fluid. The main components are dendrobe polysaccharide, dendrobine, dendrophenol and dendrolamine.
Modern pharmacological studies show that the dendrobium has the effects of resisting oxidation and aging, improving liver function, treating cataract, enhancing human immunity, reducing blood sugar, resisting thrombus, resisting tumor, resisting mutagenesis, resisting bacteria, promoting digestion and the like.
The dendrobium officinale polysaccharide has high content, is a valuable traditional Chinese medicine immunopotentiator, increases the number of peripheral white blood cells of mice with low immunity caused by cyclophosphamide, promotes lymphocytes of an immune system to generate migration inhibition factors, reduces the migration inhibition index, improves the T lymphocyte transformation function, NK activity, macrophage phagocytosis function and hemolysin value of S180 sarcoma mice, has inhibition activity on liver cancer and ehrlich ascites carcinoma cells, can remarkably enhance the effect of killing tumor cells by AK cells of Yin-blood L and blood L AK cells of tumor patients, and has the effects of reducing blood sugar of tumor radiotherapy and chemotherapy patients.
The green tea is a beverage which is prepared by processes of non-fermentation, enzyme deactivation, shaping, drying and the like, and is rich in tea polyphenol, catechin, chlorophyll, caffeine, amino acid, various vitamins and other nutrient components. Has effects of refreshing, clearing away heart-fire, clearing summerheat, resolving food stagnation, eliminating phlegm, reducing weight, clearing heart-fire, relieving restlessness, removing toxic substance, relieving hangover, promoting fluid production, quenching thirst, lowering fire, improving eyesight, relieving dysentery, and eliminating dampness, and also has certain pharmacological effects on radiation disease, cardiovascular disease, cerebrovascular disease, cancer, etc.
Tea polyphenols (mainly catechin compounds) are beneficial for preventing and adjuvant treating gastric cancer and intestinal cancer. Tea polyphenols have important effect on fat metabolism. Especially catechin ECG and EGC in tea polyphenol can inhibit plaque hyperplasia, reduce fibrinogen with increased blood coagulation viscosity, and clear blood coagulation, thereby inhibiting atherosclerosis. Tea polyphenols stimulate the change of antibody activity by increasing and maintaining the total amount of human immunoglobulin at a high level, thereby improving the overall immunological competence of human. Indirectly realizes the efficacy of inhibiting or killing various pathogens, germs and viruses. The tea polyphenol can strongly inhibit the release of histamine, and experiments prove that the inhibitory effect of tea polyphenol on allergic reaction and skin allergic reaction is 2-10 times stronger than that of the conventional common antiallergic drugs. The tea polyphenol can inhibit the allergic reaction caused by active factors such as antibodies, adrenaline, enzyme and the like, and has obvious curative effect on allergic diseases such as asthma and the like.
Lentinus edodes belongs to Basidiomycetes (Basidiomycetes), Agaricales (Agaricales), Tricholomataceae (Tricholomataceae), Lentinus (L entinus) with the scientific name of L entinus edodes, is famous edible fungus in China, is known as 'Huanghou in the mushroom' by people, is called 'mountain delicacy' in folk, is deeply loved by people, and is rare ideal health food.
The lentinan (L entinan L NT) is β (1-3) glucan which is extracted from natural lentinus edodes fruiting bodies of lentinus of Agaricaceae, and is a substance with the functions of regulating human body physiological function, enhancing human body immunity, preventing and treating various chronic diseases, especially has obvious and unique antitumor activity, and relieves the toxic and side effects of radiotherapy and chemotherapy.
As a drug, the study of lentinan began in the fifties of the twentieth century and as an immune enhancer in the sixties of the twentieth century. Since the eighties of the twentieth century, a great deal of research on lentinan turns to pharmacological and clinical research, and the results show that lentinan has an anti-tumor effect, particularly has the effects of inhibiting and preventing postoperative tumor metastasis, such as chronic myelocytic leukemia, gastric cancer, nasopharyngeal cancer, rectal cancer, breast cancer and the like, and is particularly suitable for body rehabilitation of major diseases and postoperative patients.
Lentinan is a special bioactive substance, can enhance humoral immunity and cellular immunity, and has the antiviral action mechanism of enhancing the immunity of infected cells, enhancing the stability of cell membranes, inhibiting cytopathic effect, promoting cell repair and the like. At present, a large number of lentinan health-care foods such as lentinan capsules, lentinan oral liquid and the like appear on the market.
The invention has the beneficial effects that:
in the components of the invention, the dendrobium officinale has the effects of nourishing yin and stomach, the green tea extract has the effects of clearing heat and removing toxicity, and the mushroom extract has the effects of tonifying spleen and regulating stomach and also has the effects of supporting pox and removing toxicity. The three components are rich in biological activities of improving immunity, resisting tumor, diminishing inflammation, inhibiting bacteria and the like. Especially lentinan, has long been the first-line drug for patients with tumors. The combination of the two drugs has the effects of nourishing yin, clearing heat, tonifying qi, regulating the middle warmer and detoxifying, so that the effect is better. The components of the prescription belong to the homology of medicine and food, and have the dual effects of medicine and food, thereby achieving the purposes of treating diseases and preventing diseases.
DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION
Example 1
A medicine and food dual purpose traditional Chinese medicine composition for improving human immunity comprises the following raw materials in parts by weight: 1.5 parts of dendrobium officinale, 1.0 part of green tea extract and 0.5 part of shiitake extract.
The preparation method of the medicine-food dual-purpose traditional Chinese medicine composition for improving the immunity of the human body comprises the following specific steps:
s1: cleaning Dendrobium officinale, soaking in 45 deg.C warm water for 5h, decocting with water for 2 times, and concentrating for 1h to obtain 1.0g/ml Dendrobium officinale concentrated solution;
s2, adding the green tea extract and the lentinus edodes extract into the dendrobium officinale concentrated solution, and fully and uniformly stirring; wherein the particle size of the green tea extract and the shiitake mushroom extract is 120-150 meshes.
S3, adding a flavoring agent into the product obtained in the step S2, and uniformly stirring to obtain a Chinese medicinal composition paste; wherein the mass ratio of the product obtained in the step S2 to the flavoring agent is 15:1, and the flavoring agent is composed of sucrose, maltol and citric acid in the mass ratio of 2:1: 1.
Example 2
A medicine and food dual purpose traditional Chinese medicine composition for improving human immunity comprises the following raw materials in parts by weight: 2.5 parts of dendrobium officinale, 2.0 parts of green tea extract and 1.0 part of shiitake extract.
The preparation method of the medicine-food dual-purpose traditional Chinese medicine composition for improving the immunity of the human body comprises the following specific steps:
s1: cleaning Dendrobium officinale, soaking in warm water at 55 deg.C for 3h, decocting with water for 2 times, and concentrating for 1.2h to obtain 1.1g/ml Dendrobium officinale concentrated solution;
s2, adding the green tea extract and the lentinus edodes extract into the dendrobium officinale concentrated solution, and fully and uniformly stirring; wherein the particle size of the green tea extract and the shiitake mushroom extract is 120-150 meshes.
S3, adding a flavoring agent into the product obtained in the step S2, and uniformly stirring to obtain a Chinese medicinal composition paste; wherein the mass ratio of the product obtained in the step S2 to the flavoring agent is 18:2, and the flavoring agent is composed of sucrose, maltol and citric acid in the mass ratio of 2:1: 1.
Example 3
A medicine and food dual purpose traditional Chinese medicine composition for improving human immunity comprises the following raw materials in parts by weight: 4.0 parts of dendrobium officinale, 3.0 parts of green tea extract and 1.5 parts of shiitake mushroom extract.
The preparation method of the medicine-food dual-purpose traditional Chinese medicine composition for improving the immunity of the human body comprises the following specific steps:
s1: cleaning Dendrobium officinale, soaking in 65 deg.C warm water for 2h, decocting with water for 3 times, each time for 1.5h, and concentrating to obtain 1.2g/ml Dendrobium officinale concentrated solution;
s2, adding the green tea extract and the lentinus edodes extract into the dendrobium officinale concentrated solution, and fully and uniformly stirring; wherein the particle size of the green tea extract and the shiitake mushroom extract is 120-150 meshes.
S3, adding a flavoring agent into the product obtained in the step S2, and uniformly stirring to obtain a Chinese medicinal composition paste; wherein the mass ratio of the product obtained in the step S2 to the flavoring agent is 20: 3, the flavoring agent consists of cane sugar, maltol and citric acid in a mass ratio of 2:1: 1.
Example 4
A medicine and food dual purpose traditional Chinese medicine composition for improving human immunity comprises the following raw materials in parts by weight: 2.5 parts of dendrobium officinale, 2.0 parts of green tea extract and 1.0 part of shiitake extract.
The preparation method of the medicine-food dual-purpose traditional Chinese medicine composition for improving the immunity of the human body comprises the following specific steps:
s1: cleaning Dendrobium officinale, soaking in warm water at 55 deg.C for 3h, decocting with water for 2 times, and concentrating for 1.2h to obtain 1.1g/ml Dendrobium officinale concentrated solution;
s2, adding the green tea extract and the lentinus edodes extract into the dendrobium officinale concentrated solution, and fully and uniformly stirring; wherein the particle size of the green tea extract and the shiitake mushroom extract is 120-150 meshes.
S3, adding flavoring agent and dextrin into the product obtained in the step S2, drying at 45 ℃, and granulating to obtain Chinese medicinal composition granules; wherein the mass ratio of the product obtained in the step S2, the flavoring agent and the dextrin is 18: 2: 3, the flavoring agent consists of cane sugar, maltol and citric acid in a mass ratio of 2:1: 1.
Example 5
A medicine and food dual purpose traditional Chinese medicine composition for improving human immunity comprises the following raw materials in parts by weight: 2.5 parts of dendrobium officinale, 2.0 parts of green tea extract and 1.0 part of shiitake extract.
The preparation method of the medicine-food dual-purpose traditional Chinese medicine composition for improving the immunity of the human body comprises the following specific steps:
s1: cleaning Dendrobium officinale, soaking in warm water at 55 deg.C for 3h, decocting with water for 2 times, and concentrating for 1.2h to obtain 1.1g/ml Dendrobium officinale concentrated solution;
s2, adding the green tea extract and the lentinus edodes extract into the dendrobium officinale concentrated solution, and fully and uniformly stirring; wherein the particle size of the green tea extract and the shiitake mushroom extract is 120-150 meshes.
S3, adding a flavoring agent and dextrin into the product obtained in the step S2, drying at 45 ℃, and tabletting to obtain a traditional Chinese medicine composition tablet, wherein the mass ratio of the product obtained in the step S2 to the flavoring agent to the dextrin is 18: 2: 3, the flavoring agent consists of cane sugar, maltol and citric acid in a mass ratio of 2:1: 1.
Toxicology test
According to a literature method (traditional Chinese medicine pharmacology research methodology, Chengqi Master eds., people health publisher, 1993 version 1, 112), 40 mice are taken, the male and female halves are respectively taken, the weight is 20 +/-2 g, the mice are divided into a normal control group and an administration group, the mice are intragastrically filled with 0.4m L medicament (the maximum volume is reached) per 10g of the weight, the administration is carried out twice a day (the normal control group is given with physiological saline with the same volume), the intragastrically filled medicament is the granules prepared by the invention, the concentration after the intragastrically filled medicament is 1g/m L, the administration is immediately observed for 6 hours, the daily observation is carried out for 14 consecutive days, the anatomical observation is carried out on the 8 th day, the continuous observation is carried out for 7 days, the animals are smooth and lively, natural pores are clear, the feces and urine are normal, no macroscopic lesion is found in each main organ of the mice after the anatomical observation, the maximum administration amount of the mice reaches 80g/kg, the weight coefficient is reduced, the daily dosage of 4800g of an adult (60 kg) is far higher than the clinical dosage, and.
And (3) clinical observation statistics:
1. observing an object:
252 patients with malignant tumors after surgery were selected as the observation subjects, and the observation subjects were divided into 126 patients in the treatment group and the control group on average. The difference between the two groups of patients in terms of sex, age, disease species and the like is not statistically significant and has comparability.
2. Selecting the medicines:
experimental groups: the traditional Chinese medicine composition granules are taken 3 times a day and 3g each time while chemotherapy is carried out, and are dissolved in water for patients to take for 2 months continuously.
Control group: the oral liquid of lentinan is taken at the same time of chemotherapy according to the instruction, and is taken for 2 months continuously.
3. And (3) judging the curative effect:
the evaluation standard (draft) of the traditional Chinese medicine tumor curative effect of solid tumor is made by experts in the traditional Chinese medicine tumor world compiled by Zhoudahi Daihin Master (clinical traditional Chinese medicine oncology). The evaluation of the life quality condition of the tumor patients adopts the international universal Karnofsky score standard, the score increase before and after treatment is more than or equal to 10 and is divided into improvement, the score increase or decrease is less than 10 and is divided into stabilization, and the score decrease is more than or equal to 10 and is divided into deterioration.
The two groups of patients were compared in efficacy and the results are shown in table 1.
TABLE 1 comparison of the efficacy of the two groups of patients
| Group of | Improvement of life | Stabilization | Deterioration of |
| Experimental group | 75 persons | 41 persons | 10 persons |
| Control group | 65 persons | 36 persons | 25 persons |
As can be seen from the table 1, the traditional Chinese medicine preparation of the invention has better effect than the lentinan oral liquid in the aspect of treating tumors by matching with chemotherapy.
Typical cases
Case 1, Liu Ji, male, age 68. Initial diagnosis in 2 months and 10 days in 2017. The patient is hospitalized for 2 days in 2017, 7 months and 2 days due to confirmed acute myelogenous leukemia with cough and fever. After treatment of anti-infection, spasmolysis and asthma relief, phlegm reduction, blood pressure control and the like, the body temperature returns to normal, and the patient is discharged from the hospital in 2017, 2 months and 7 days. Examination at discharge suggested that leukocytes were 2.39 (10)～9/L), percent neutrophils 34.30 (%), red blood cell count 3.93 (10)～12/L), hemoglobin 97 (g/L), platelet count 70 (10)～9/L) patients have serious reaction due to multiple chemotherapy of myeloid leukemia, refusing to continue chemotherapy, conscious body fatigue, sleepiness, poor appetite and qi asthenia, giving dendrobium and tea mushroom granules (granules of the invention) 1 day 3 times, 1 time 3g, after taking for 1 week, the subjective symptoms are greatly improved, the diet returns to normal, laboratory review in 2017, 2 months and 20 days suggests that the leucocyte 5.41 (10)～9/L), neutrophil percentage 42.84 (%), red blood cell count 4.93 (10)～12/L), hemoglobin 122 (g/L), platelet count 118 (10)～9/L), the dendrobium tea mushroom grains are continuously taken for 1 month, then the administration is changed into 1 day for 2 times and 1 time for 3 grams, the administration is continuously continued for 2 months, then the self feeling is realized, the intermittent continuous administration is carried out for nearly half a year, the follow-up visit is carried out for 2 years, the chemotherapy is stopped, the body condition is self-felt, the chess and card activities are carried out for a plurality of hours every day, and the journey is carried out once a year.
Case 2, lie, male, 65 years old. Initial diagnosis in 2018, 4 months and 20 days. In 2016, patients are admitted to hospital for examination for 1 year after cough, expectoration and blood-carrying sputum, and the examination confirms that the patients are diagnosed as left lung lower lobe central lung cancer with multiple small nodules, and lung cancer metastasis is considered. Single port thoracoscopic left hypovolemic lobectomy was performed 11 months and 29 days 2016. Multiple times of postoperative chemotherapy of pemetrexed + lobaplatin. CT examination of 4 months and 16 days in 2018 indicates that multiple nodules and frosting at the rear segment of the upper lobe of the left lung, the tongue segment, the upper lobe of the right lung and the outer side of the middle lobe of the right lung have slightly increased FDG metabolism, delayed imaging metabolism is obviously increased, multiple osteogenic bone damages occur to the 5 th thoracic vertebra, the 3 rd lumbar vertebra, the left side part of the 3 rd sacral vertebra, the right iliac body and the right femoral head, and the possibility of metastatic tumor is considered to be large. The patient feels sleepy, and has inappetence, nausea, dry cough, choking cough, and dyspnea. The dendrobe tea mushroom granules are given for 1 day for 3 times, and 1 time for 3 g. And 7, 7 and 26 days of repeated diagnosis in 2018. After the medicine is continuously taken for 3 months, the self feeling is good, the cough is cured, and the diet is normal. The metastatic focus of the lung part is not obviously enlarged in the CT rechecking. The sustained dose of the dendrobium tea mushroom granules is continuously taken. And 7, the patient is re-diagnosed in 2018, 11 and 26 days. The CT examination result indicates that two lungs have multiple nodule foci, and the two lungs have no obvious change compared with the prior CT examination, and the laboratory examination indicates that the carcinoembryonic antigen is 2.36 ng/ml; carbohydrate antigen 199: 15.10U/ml; carbohydrate antigen 125: 14.5U/ml; carbohydrate antigen 153: 8.1U/ml; alpha-fetoprotein 5.43 ng/ml. Indicating stable disease condition. The granule is administered continuously.
Case 3, Liu Ji, female, age 44. Initial diagnosis in 2019, 10 and 2 days. The oral ulcer of a patient has recurrent attacks for 4 years, and the effect of taking Chinese and western medicines by many people is poor. In 2018, 8 and 27 days, Western medicine tamoxifen citrate tablets are taken after operation due to breast cancer operation treatment, oral ulcer attacks are increasingly frequent, throat swelling and pain are accompanied, eating is difficult, sleep is not achieved at night, and dysphoria and irritability are caused. The dendrobium tea mushroom granules are given for 1 day and 3 times, 1 time and 3g, and the oral ulcer is healed after the dendrobium tea mushroom granules are taken for 5 days. And then, continuously taking the dendrobe tea mushroom granules for 1 month. After 3 months of follow-up visit, the oral ulcer does not relapse, the diet and the stool are normal, the sleep is good, and the emotion is better and better.
Case 4, Wu-chi, female, age 42, initial diagnosis in 2016, 8 months and 29 days. The chronic urticaria has repeated attacks for years, the relapse lasts for more than 1 month, and the traditional Chinese medicine and the western medicine are taken, so that the effect is poor, the dysphoria, insomnia at night and obvious pruritus are achieved. The Chinese medicinal preparation has effects in clearing heat, cooling blood, calming endogenous wind, and relieving itching, and is administered 1 time in the morning and evening respectively for 2 times a day; the dendrobium-tea mushroom granule is used for 3 times 1 day and 3 grams for 1 time. After taking the medicine for 2 days, the rash blocks obviously disappear, the pruritus is relieved, and the user can sleep for 5 to 6 hours every night. After taking for 5 days, the rubella is completely removed, the pruritus is stopped, and the patient can normally fall asleep at night. After that, the dendrobium tea mushroom particles are continuously taken for 1 month, and the rubella does not relapse after the follow-up visit for 3 years.
Claims (10)
1. A medicine and food dual purpose Chinese medicinal composition for improving human immunity is characterized in that: the feed comprises the following raw materials in parts by weight: 1.5-4.0 parts of dendrobium officinale, 1.0-3.0 parts of green tea extract and 0.5-1.5 parts of shiitake extract.
2. The medical and edible traditional Chinese medicine composition for improving human immunity according to claim 1, which is characterized in that: the feed comprises the following raw materials in parts by weight: 2.5 parts of dendrobium officinale, 2.0 parts of green tea extract and 1.0 part of shiitake extract.
3. A preparation method of the medicine-food dual-purpose traditional Chinese medicine composition for improving human immunity according to claim 1 or 2, which is characterized by comprising the following steps: the method comprises the following specific steps:
s1: cleaning Dendrobium officinale, soaking in warm water, decocting in water, and concentrating the decoction to obtain Dendrobium officinale concentrated solution;
s2, adding the green tea extract and the lentinus edodes extract into the dendrobium officinale concentrated solution, and fully and uniformly stirring;
s3, adding a flavoring agent into the product obtained in the step S2, and uniformly stirring to obtain a Chinese medicinal composition paste;
or adding flavoring agent and dextrin into the product obtained in step S2, drying at low temperature, and granulating to obtain Chinese medicinal composition granule;
or adding flavoring agent and dextrin into the product obtained in step S2, drying at low temperature, and tabletting to obtain Chinese medicinal composition tablet.
4. The preparation method of the medicinal and edible traditional Chinese medicine composition for improving human immunity according to claim 3, which is characterized by comprising the following steps: the soaking temperature in the step S1 is 45-65 ℃, the soaking time is 2-5h, the times of adding water for decoction are 2-3 times, and the time of each time of decoction is 1-1.5 h.
5. The preparation method of the medicinal and edible traditional Chinese medicine composition for improving human immunity according to claim 3, which is characterized by comprising the following steps: in the step S1, the concentration of the dendrobium officinale concentrated solution is 1.20-1.25 g/ml.
6. The preparation method of the medicinal and edible traditional Chinese medicine composition for improving human immunity according to claim 3, which is characterized by comprising the following steps: in step S2, the particle size of the green tea extract and the shiitake mushroom extract is 120-150 meshes.
7. The preparation method of the medicinal and edible traditional Chinese medicine composition for improving human immunity according to claim 3, which is characterized by comprising the following steps: in the step S3, in the traditional Chinese medicine composition ointment, the mass ratio of the product obtained in the step S2 to the flavoring agent is 15-20: 1-3.
8. The preparation method of the medicinal and edible traditional Chinese medicine composition for improving human immunity according to claim 3, which is characterized by comprising the following steps: in the step S3, in the traditional Chinese medicine composition granules, the mass ratio of the product in the step S2, the flavoring agent and the dextrin is 15-20: 1-3: 2-6, and the low-temperature drying temperature is 40-50 ℃.
9. The preparation method of the medicinal and edible traditional Chinese medicine composition for improving human immunity according to claim 3, which is characterized by comprising the following steps: in the step S3, in the Chinese medicinal composition tablet, the mass ratio of the product in the step S2, the flavoring agent and the dextrin is 15-20: 1-3: 2-6, and the low-temperature drying temperature is 40-50 ℃.
10. The preparation method of the medicinal and edible traditional Chinese medicine composition for improving human immunity according to claim 3, which is characterized by comprising the following steps: in step S3, the flavoring agent is composed of sucrose, maltol, and citric acid in a mass ratio of 2:1: 1.
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