CN111493082A - Foam type household disinfectant and preparation method thereof - Google Patents
Foam type household disinfectant and preparation method thereof Download PDFInfo
- Publication number
- CN111493082A CN111493082A CN202010320492.8A CN202010320492A CN111493082A CN 111493082 A CN111493082 A CN 111493082A CN 202010320492 A CN202010320492 A CN 202010320492A CN 111493082 A CN111493082 A CN 111493082A
- Authority
- CN
- China
- Prior art keywords
- parts
- foam
- essential oil
- quaternary ammonium
- disinfectant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000645 desinfectant Substances 0.000 title claims abstract description 64
- 239000006260 foam Substances 0.000 title claims abstract description 61
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 239000000341 volatile oil Substances 0.000 claims abstract description 61
- -1 quaternary ammonium salt compounds Chemical class 0.000 claims abstract description 56
- 239000003242 anti bacterial agent Substances 0.000 claims abstract description 40
- 239000004088 foaming agent Substances 0.000 claims abstract description 29
- 239000003974 emollient agent Substances 0.000 claims abstract description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 150000004283 biguanides Chemical class 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 11
- 239000004872 foam stabilizing agent Substances 0.000 claims abstract description 9
- 150000001298 alcohols Chemical class 0.000 claims abstract description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 80
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 33
- 239000000203 mixture Substances 0.000 claims description 33
- 241000196324 Embryophyta Species 0.000 claims description 24
- 239000003381 stabilizer Substances 0.000 claims description 24
- 238000003756 stirring Methods 0.000 claims description 24
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical group [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 23
- 235000007866 Chamaemelum nobile Nutrition 0.000 claims description 21
- 229940123208 Biguanide Drugs 0.000 claims description 19
- 235000007232 Matricaria chamomilla Nutrition 0.000 claims description 14
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 12
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 125000005233 alkylalcohol group Chemical group 0.000 claims description 10
- 239000004599 antimicrobial Substances 0.000 claims description 10
- 239000002245 particle Substances 0.000 claims description 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 7
- 239000002736 nonionic surfactant Substances 0.000 claims description 7
- 239000002280 amphoteric surfactant Substances 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 4
- 150000003856 quaternary ammonium compounds Chemical class 0.000 claims description 4
- 235000005979 Citrus limon Nutrition 0.000 claims description 3
- 244000131522 Citrus pyriformis Species 0.000 claims description 3
- 244000178870 Lavandula angustifolia Species 0.000 claims description 3
- 235000010663 Lavandula angustifolia Nutrition 0.000 claims description 3
- 235000006679 Mentha X verticillata Nutrition 0.000 claims description 3
- 235000002899 Mentha suaveolens Nutrition 0.000 claims description 3
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims description 3
- 241000220317 Rosa Species 0.000 claims description 3
- 244000223014 Syzygium aromaticum Species 0.000 claims description 3
- 235000016639 Syzygium aromaticum Nutrition 0.000 claims description 3
- 239000001102 lavandula vera Substances 0.000 claims description 3
- 235000018219 lavender Nutrition 0.000 claims description 3
- 244000042664 Matricaria chamomilla Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 23
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 23
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 38
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 22
- 240000003538 Chamaemelum nobile Species 0.000 description 20
- 210000003491 skin Anatomy 0.000 description 17
- 235000011187 glycerol Nutrition 0.000 description 13
- UBHWBODXJBSFLH-UHFFFAOYSA-N hexadecan-1-ol;octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO.CCCCCCCCCCCCCCCCCCO UBHWBODXJBSFLH-UHFFFAOYSA-N 0.000 description 12
- 230000001954 sterilising effect Effects 0.000 description 12
- 229940081733 cetearyl alcohol Drugs 0.000 description 11
- 229960000541 cetyl alcohol Drugs 0.000 description 11
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 description 11
- 229940073507 cocamidopropyl betaine Drugs 0.000 description 11
- SYELZBGXAIXKHU-UHFFFAOYSA-N dodecyldimethylamine N-oxide Chemical compound CCCCCCCCCCCC[N+](C)(C)[O-] SYELZBGXAIXKHU-UHFFFAOYSA-N 0.000 description 11
- 229940087291 tridecyl alcohol Drugs 0.000 description 11
- 241000894006 Bacteria Species 0.000 description 10
- XFRVVPUIAFSTFO-UHFFFAOYSA-N 1-Tridecanol Chemical compound CCCCCCCCCCCCCO XFRVVPUIAFSTFO-UHFFFAOYSA-N 0.000 description 9
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 9
- 241000700605 Viruses Species 0.000 description 8
- KJIOQYGWTQBHNH-UHFFFAOYSA-N undecanol Chemical compound CCCCCCCCCCCO KJIOQYGWTQBHNH-UHFFFAOYSA-N 0.000 description 8
- 230000001580 bacterial effect Effects 0.000 description 7
- 239000004604 Blowing Agent Substances 0.000 description 6
- 230000000844 anti-bacterial effect Effects 0.000 description 6
- KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 description 5
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 239000006071 cream Substances 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 230000007774 longterm Effects 0.000 description 4
- 229940051841 polyoxyethylene ether Drugs 0.000 description 4
- 229920000056 polyoxyethylene ether Polymers 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 229940057402 undecyl alcohol Drugs 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 3
- 239000012752 auxiliary agent Substances 0.000 description 3
- RSMBRLAXHPRAAU-UHFFFAOYSA-M bis(2-hydroxyethyl)-methyl-undecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCC[N+](C)(CCO)CCO RSMBRLAXHPRAAU-UHFFFAOYSA-M 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 230000007547 defect Effects 0.000 description 3
- VICYBMUVWHJEFT-UHFFFAOYSA-N dodecyltrimethylammonium ion Chemical compound CCCCCCCCCCCC[N+](C)(C)C VICYBMUVWHJEFT-UHFFFAOYSA-N 0.000 description 3
- 230000002147 killing effect Effects 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 150000003384 small molecules Chemical class 0.000 description 3
- 230000002195 synergetic effect Effects 0.000 description 3
- 208000019901 Anxiety disease Diseases 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 230000036506 anxiety Effects 0.000 description 2
- 229960003237 betaine Drugs 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 210000000805 cytoplasm Anatomy 0.000 description 2
- 239000003344 environmental pollutant Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 238000005187 foaming Methods 0.000 description 2
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 231100000719 pollutant Toxicity 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- 210000000434 stratum corneum Anatomy 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 235000013311 vegetables Nutrition 0.000 description 2
- GIEMHYCMBGELGY-UHFFFAOYSA-N 10-undecen-1-ol Chemical compound OCCCCCCCCCC=C GIEMHYCMBGELGY-UHFFFAOYSA-N 0.000 description 1
- BWDBEAQIHAEVLV-UHFFFAOYSA-N 6-methylheptan-1-ol Chemical compound CC(C)CCCCCO BWDBEAQIHAEVLV-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 229920000832 Cutin Polymers 0.000 description 1
- OJIYIVCMRYCWSE-UHFFFAOYSA-M Domiphen bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CCOC1=CC=CC=C1 OJIYIVCMRYCWSE-UHFFFAOYSA-M 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 239000000232 Lipid Bilayer Substances 0.000 description 1
- AOMUHOFOVNGZAN-UHFFFAOYSA-N N,N-bis(2-hydroxyethyl)dodecanamide Chemical group CCCCCCCCCCCC(=O)N(CCO)CCO AOMUHOFOVNGZAN-UHFFFAOYSA-N 0.000 description 1
- 208000037581 Persistent Infection Diseases 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- XKTMPGNYHJBJNK-UHFFFAOYSA-N [Br-].[NH4+].C(CCCCCCCCCCCCC)C1=C(C(=NC=C1)C)C Chemical compound [Br-].[NH4+].C(CCCCCCCCCCCCC)C1=C(C(=NC=C1)C)C XKTMPGNYHJBJNK-UHFFFAOYSA-N 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- JBIROUFYLSSYDX-UHFFFAOYSA-M benzododecinium chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 JBIROUFYLSSYDX-UHFFFAOYSA-M 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 150000001721 carbon Chemical group 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 229940082500 cetostearyl alcohol Drugs 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 239000008406 cosmetic ingredient Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- DDXLVDQZPFLQMZ-UHFFFAOYSA-M dodecyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)C DDXLVDQZPFLQMZ-UHFFFAOYSA-M 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-N guanidine group Chemical group NC(=N)N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 229940031957 lauric acid diethanolamide Drugs 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 210000001533 respiratory mucosa Anatomy 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- GLFDLEXFOHUASB-UHFFFAOYSA-N trimethyl(tetradecyl)azanium Chemical compound CCCCCCCCCCCCCC[N+](C)(C)C GLFDLEXFOHUASB-UHFFFAOYSA-N 0.000 description 1
- CEYYIKYYFSTQRU-UHFFFAOYSA-M trimethyl(tetradecyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+](C)(C)C CEYYIKYYFSTQRU-UHFFFAOYSA-M 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/12—Asteraceae or Compositae [Aster or Sunflower family], e.g. daisy, pyrethrum, artichoke, lettuce, sunflower, wormwood or tarragon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L9/00—Disinfection, sterilisation or deodorisation of air
- A61L9/01—Deodorant compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L9/00—Disinfection, sterilisation or deodorisation of air
- A61L9/01—Deodorant compositions
- A61L9/013—Deodorant compositions containing animal or plant extracts, or vegetable material
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
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Abstract
The invention relates to the technical field of disinfection, in particular to a foam type household disinfectant and a preparation method thereof; the preparation raw materials at least comprise the following components in parts by weight: 5-15 parts of biguanide compounds, 10-20 parts of quaternary ammonium salt compounds, 0.1-3.5 parts of foaming agents, 2-6 parts of foam stabilizers, 15-25 parts of small molecular alcohols, 1-5 parts of emollients, 3-6 parts of plant essential oil, 2.3-5.8 parts of antibacterial agents and 60-80 parts of water; the foam type household disinfectant provided by the invention has excellent sterilization and disinfection effects, and can be used for adsorbably removing peculiar smell without damaging skin, so that the safety is high.
Description
Technical Field
The invention relates to the technical field of disinfection, in particular to a foam type household disinfectant and a preparation method thereof.
Background
Indoor pollution is 2-5 times higher than outdoor pollution, and serious pollution is even dozens of times higher than outdoor pollution. Most of the existing disinfectants appear in liquid or gel form. When in use, the liquid is easy to spill, and the disinfection effect is influenced due to uneven smearing. The gel system is thick and has obvious sticky feeling after use. The existing disinfectant stimulates the skin and has poor lasting effect; many of the substances form pollutants such as formaldehyde, which affects human health, and the peculiar smell cannot be eliminated quickly after disinfection, so that the long-term use of the disinfectant can cause the danger of accumulated poisoning to human bodies.
The foam disinfectant prepared from the aldehyde and active chlorine preparations used at present has strong pungent smell, irritation to respiratory mucosa of human, corrosive action to metal equipment in the using process and short foam half-life. And the disinfectant is lack of high-efficiency cleaning and decontaminating functions, so that the disinfectant can not be thoroughly cleaned after disinfecting pollutants at hidden positions such as objects, wall surfaces, recesses of appliances, gaps and the like in the using process, residues are fermented in a short time, and a hotbed is provided for the propagation and propagation of bacteria.
For this reason, the development of a foam type household disinfectant having safety has been the focus of research by those skilled in the art.
Disclosure of Invention
In order to solve the technical problems, the invention provides a foam type household disinfectant, which comprises the following raw materials in parts by weight: 5-15 parts of biguanide compounds, 10-20 parts of quaternary ammonium salt compounds, 0.1-3.5 parts of foaming agents, 2-6 parts of foam stabilizers, 15-25 parts of small molecular alcohols, 1-5 parts of emollients, 3-6 parts of plant essential oil, 2.3-5.8 parts of antibacterial agents and 60-80 parts of water.
As a preferred technical solution of the present invention, the plant essential oil is selected from one or more of lemon essential oil, chamomile essential oil, lavender essential oil, rose essential oil, clove essential oil, and mint essential oil.
As a preferable technical solution of the present invention, the quaternary ammonium salt compound is a single-chain quaternary ammonium salt compound.
As a preferable technical scheme of the invention, the foaming agent is alkyl alcohol ether.
As a preferable technical scheme of the invention, the length of the carbon chain in the alkyl alcohol ether is C10-C16.
In a preferred embodiment of the present invention, the foam stabilizer is a nitrogen-containing amphoteric surfactant or a nitrogen-containing nonionic surfactant.
In a preferred embodiment of the present invention, the antibacterial agent is an inorganic antibacterial agent.
As a preferable technical scheme of the invention, the antibacterial agent is a nano-silver antibacterial agent.
As a preferable technical scheme of the invention, the particle size of the nano-silver antibacterial agent is 1-10 nm.
The second aspect of the present invention provides a method for preparing a foam type home disinfectant, characterized in that the preparation method comprises the steps of:
(1) adding a foaming agent and a foam stabilizer into micromolecular alcohol, and stirring and dissolving to obtain a mixture A;
(2) adding a biguanide compound, a quaternary ammonium salt compound and an antibacterial agent into water, heating to 40-60 ℃, and stirring for dissolving to obtain a mixture B;
(3) cooling mixture B to room temperature, adding mixture A into mixture B, stirring at low speed for 10-15min, adding plant essential oil and emollient, and stirring at high speed.
Has the advantages that: the invention provides a foam type household disinfectant and a preparation method thereof, wherein a biguanide compound, a quaternary ammonium salt compound, micromolecular alcohol and an antibacterial agent are cooperatively used to effectively improve the sterilization effect of the foam type disinfectant, and meanwhile, the combination of a foaming agent and a foam stabilizer not only enables the disinfectant to generate stable and uniform foam, but also effectively improves the stability of the quaternary ammonium salt compound at low temperature, and further improves the sterilization effect of the foam disinfectant at low temperature; in addition, the plant essential oil and the emollient are added, so that the foam disinfectant has excellent sterilization and disinfection effects, can adsorb and remove peculiar smell, does not damage skin, and is high in safety.
Detailed Description
The disclosure may be understood more readily by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.
The term "prepared from …" as used herein is synonymous with "comprising". The terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.
The conjunction "consisting of …" excludes any unspecified elements, steps or components. If used in a claim, the phrase is intended to claim as closed, meaning that it does not contain materials other than those described, except for the conventional impurities associated therewith. When the phrase "consisting of …" appears in a clause of the subject matter of the claims rather than immediately after the subject matter, it defines only the elements described in the clause; other elements are not excluded from the claims as a whole.
When an amount, concentration, or other value or parameter is expressed as a range, preferred range, or as a range of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when a range of "1 to 5" is disclosed, the described range should be interpreted to include the ranges "1 to 4", "1 to 3", "1 to 2 and 4 to 5", "1 to 3 and 5", and the like. When a range of values is described herein, unless otherwise stated, the range is intended to include the endpoints thereof and all integers and fractions within the range.
The singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. "optional" or "any" means that the subsequently described event or events may or may not occur, and that the description includes instances where the event occurs and instances where it does not.
Approximating language, as used herein throughout the specification and claims, is intended to modify a quantity, such that the invention is not limited to the specific quantity, but includes portions that are literally received for modification without substantial change in the basic function to which the invention is related. Accordingly, the use of "about" to modify a numerical value means that the invention is not limited to the precise value. In some instances, the approximating language may correspond to the precision of an instrument for measuring the value. In the present description and claims, range limitations may be combined and/or interchanged, including all sub-ranges contained therein if not otherwise stated.
In addition, the indefinite articles "a" and "an" preceding an element or component of the invention are not intended to limit the number requirement (i.e., the number of occurrences) of the element or component. Thus, "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural unless the stated number clearly indicates that the singular form is intended.
In order to solve the technical problems, the invention provides a foam type household disinfectant, which comprises the following raw materials in parts by weight: 5-15 parts of biguanide compounds, 10-20 parts of quaternary ammonium salt compounds, 2-5 parts of foaming agents, 4-10 parts of foam stabilizers, 15-25 parts of micromolecular alcohols, 1-5 parts of emollients, 3-6 parts of vegetable essential oil, 2.3-5.8 parts of antibacterial agents and 40-60 parts of water.
In a preferred embodiment, the foam type household disinfectant provided by the invention is prepared from at least the following raw materials in parts by weight: 7-11 parts of biguanide compounds, 12-18 parts of quaternary ammonium salt compounds, 2.5-4 parts of foaming agents, 6-9 parts of foam stabilizers, 18-21 parts of micromolecular alcohol, 2-4 parts of emollients, 4-5 parts of vegetable essential oil, 3-5 parts of antibacterial agents and 45-55 parts of water.
In a most preferred embodiment, the foam type household disinfectant of the present invention is prepared from at least the following raw materials in parts by weight: 10 parts of biguanide compounds, 15 parts of quaternary ammonium compounds, 3 parts of foaming agents, 8 parts of foam stabilizers, 19 parts of small molecular alcohol, 3.5 parts of emollients, 4.5 parts of plant essential oil, 4 parts of antibacterial agents and 50 parts of water.
Biguanide compounds
The biguanide compound of the invention refers to a compound containing at least one biguanide group.
In a preferred embodiment, the biguanide compound of the present invention is a biguanide compound having a substituted phenyl group at a terminal thereof.
In a most preferred embodiment, the biguanide compound of the present invention is chlorhexidine gluconate with a CAS number of 18472-51-0.
The biguanide compound with the terminal containing the substituted phenyl group has important biological activity, particularly has quite strong broad-spectrum antibacterial and bactericidal effects on chlorhexidine gluconate, has antibacterial property on wounds or skin tissues in medicine, and is widely applied to disinfection of fiber tissues, bed sheets, carpets, clothes and the like.
Quaternary ammonium salt compound
The quaternary ammonium salt compound is also called quaternary ammonium salt, has various types, is a compound generated by replacing four hydrogen atoms in ammonium ions with alkyl, and has a general formula R4NX, wherein the four hydrocarbon radicals R can be the same or different, and X is mostly halogen anion (F, Cl, Br, I).
In a preferred embodiment, the quaternary ammonium salt compound of the present invention is a single-chain quaternary ammonium salt compound.
In a more preferred embodiment, the quaternary ammonium salt compound according to the present invention is selected from one or more of dodecyl dimethyl benzyl ammonium chloride, dodecyl dimethyl benzyl ammonium bromide, dodecyl dimethyl phenoxyethyl ammonium bromide, tetradecyl dimethyl pyridine ammonium bromide, dodecyl trimethyl ammonium chloride, dodecyl trimethyl ammonium, trimethyl tetradecyl ammonium chloride, di (2-hydroxyethyl) -methyl-undecyl ammonium chloride.
Wherein the CAS of dodecyltrimethylammonium is 10182-91-9, the CAS of trimethyltetradecylammonium is CAS10182-92-0, and the CAS of bis (2-hydroxyethyl) -methyl-undecanylammonium chloride is 102571-42-6.
In a most preferred embodiment, the quaternary ammonium salt compound of the present invention is dodecyldimethylbenzyl ammonium bromide.
The inventor finds that by adding the biguanide compound and the quaternary ammonium salt compound into a formula system and utilizing the synergistic effect of the biguanide compound and the quaternary ammonium salt compound, the defect of common virus killing effect when the biguanide compound is used alone can be overcome, the disinfection capability of the quaternary ammonium salt compound can be improved, the disinfection and sterilization effects of the foam type household disinfectant can be effectively improved, and the application range of the disinfectant can be enlarged; in particular, the single-chain quaternary ammonium salt and the biguanide compound with the end containing the substituted phenyl are compounded, so that the effect is optimal; the possible reasons are that the guanidine group and the quaternary ammonium salt cooperate to further improve the electropositivity in the system, so that the bacterial virus is more easily adsorbed, the interaction between molecules is damaged, the lipid bilayer of the cell membrane is disrupted, the control of cytoplasm permeability is influenced, and cytoplasm leakage is caused, so that the bacteria and the virus cannot divide and reproduce and lose activity, other biomolecules existing in the bacterial cell are also decomposed, and the inactivation effect cannot be influenced even if the bacterial virus is mutated; however, the single-chain quaternary ammonium salt has the defect of easy precipitation at low temperature, and the application range of the disinfectant is seriously influenced.
Foaming agent
The foaming agent is a surface active substance, and is mainly used for reducing the interfacial tension on an air-water interface, promoting air to form small bubbles in slurry, expanding a separation interface and ensuring that the bubbles rise to form a foam layer.
In a preferred embodiment, the blowing agent of the present invention is an alkyl alcohol ether.
In a more preferred embodiment, the carbon chain length in the alkyl alcohol ether of the present invention is from C10 to C16.
In a more preferred embodiment, the foaming agent of the present invention is a combination of tridecyl alcohol decapolyoxyethylene ether, cetyl alcohol octapolyoxyethylene ether, and undecyl alcohol hexapolyoxyethylene ether, wherein the mass ratio of tridecyl alcohol decapolyoxyethylene ether, cetyl alcohol octapolyoxyethylene ether, and undecyl alcohol hexapolyoxyethylene ether is 1: 1.5: (0.5-1.3).
In a most preferred embodiment, the foaming agent of the present invention is a combination of tridecyl alcohol dodecyl polyoxyethylene ether, cetyl alcohol octapolyoxyethylene ether and undecyl alcohol hexapolyoxyethylene ether, wherein the mass ratio of the tridecyl alcohol dodecyl polyoxyethylene ether, the cetyl alcohol octapolyoxyethylene ether and the undecyl alcohol hexapolyoxyethylene ether is 1: 1.5: 0.8.
the inventor finds that the alkyl alcohol ether is used as a foaming agent and added into a formula system, the hydrophilic group is inserted into the water phase, the lipophilic group is inserted into the oil phase or is erected in the air, and directional arrangement is formed on the interface layer or the surface, so that the interface tension or the surface tension is reduced, the disinfectant is favorable for generating rich foam, the contact time and the contact area of the disinfectant with the air and bacteria on the surface of an object can be increased after the disinfectant is sprayed for use, the sterilization rate can be improved, the use amount of the disinfectant can be reduced, energy is saved, emission is reduced, and the labor cost is reduced to a certain extent. The inventor unexpectedly finds that the precipitation of the single-chain quaternary ammonium salt at low temperature can be further slowed down by controlling the length of the carbon chain in the alkyl alcohol ether, and the possible reason is that the compound with the long carbon chain and the hydrophilic group is selected, wherein the long carbon chain can form a complex network structure with the quaternary ammonium salt to wrap the single-chain quaternary ammonium salt, so that the molecular mobility of the single-chain quaternary ammonium salt in a system is reduced, and the crystallization capacity is reduced; the surface activity of the non-polar group alkyl of the foaming agent can be increased by about 3 times when the non-polar group alkyl of the foaming agent is added with one carbon atom, so that the foaming capability can be increased, and the existence stability of the single-chain quaternary ammonium salt at low temperature can be improved; however, the non-polar group of the blowing agent is too long, and the solubility thereof is significantly reduced, resulting in a decrease in the blowing ability; long-term experimental research of the inventor shows that the alkyl alcohol ether has better effect when the carbon chain length is C10-C16.
Foam stabilizer
The foam stabilizer of the present invention refers to a surfactant having long-lasting and stable foam retention properties.
In a preferred embodiment, the foam stabilizer of the present invention is a nitrogen-containing amphoteric surfactant or a nitrogen-containing nonionic surfactant.
In a more preferred embodiment, the foam stabilizer of the present invention is an amine oxide and/or a betaine.
In a more preferred embodiment, the foam stabilizer of the present invention is a combination of dodecyl dimethyl amine oxide and cocamidopropyl betaine, wherein the mass ratio of dodecyl dimethyl amine oxide to cocamidopropyl betaine is 2: (0.6-1.5).
In a most preferred embodiment, the foam stabilizer of the present invention is a combination of dodecyl dimethyl amine oxide and cocamidopropyl betaine, wherein the mass ratio of dodecyl dimethyl amine oxide to cocamidopropyl betaine is 2: 1.
the inventor finds in experiments that foam generated by the disinfectant can be further stabilized by adding the foam stabilizer, and particularly, the nitrogen-containing amphoteric surfactant or the nitrogen-containing nonionic surfactant can achieve the effect of stabilizing foam and has the advantages of sterilization, calcium soap dispersibility, wettability, detergency and the like, so that the disinfectant provided by the invention has a high-efficiency sterilization effect and a cleaning effect. In addition, the invention unexpectedly discovers in experiments that the sterilization effect of the disinfectant at low temperature can be improved by selecting the nitrogen-containing amphoteric surfactant or the nitrogen-containing nonionic surfactant, and the reason for the existence of the nitrogen-containing amphoteric surfactant or the nitrogen-containing nonionic surfactant is that the foam stabilizer is well compatible with the cationic surfactant and the alkyl alcohol ether at low temperature and has good synergistic effect, particularly the compounding of the amine oxide and the betaine can effectively overcome the defect that the sterilization effect of the coated nonionic surfactant and the single-chain quaternary ammonium salt is hindered, and further enhance the sterilization and disinfection capability of the quaternary ammonium salt at low temperature.
Small molecule alcohol
In a preferred embodiment, the small molecule alcohol of the present invention is selected from methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol.
In a more preferred embodiment, the small molecule alcohol of the present invention is ethanol.
According to the invention, the micromolecular alcohol is added into the formula system, so that the compatibility of the system can be improved, a certain bactericidal capacity is realized, and the protein is denatured by destroying peptide bonds of the protein; invade cells, release the water film on the surface of proteins, inactivate them, reduce the metabolism of microorganisms, kill bacteria and most fungi and viruses. However, long-term use of disinfectants containing alcohols leads to the uncomfortable phenomena of skin chapping, dryness and the like, and increases the use cost of the disinfectants, for example, the disinfectants need to wear gloves and the like when in use.
Skin-moistening agent
The emollients of the present invention are cosmetic ingredients that help maintain the soft, pliable, smooth appearance of the skin. The function of emollients is to remain on the skin surface and to provide lubrication within the stratum corneum. Generally, the skin fills the spaces in the skin surface, replacing the lipid lost in the stratum corneum, reducing the scaly skin, and improving the appearance of the skin.
In a preferred embodiment, the emollient of the present invention is selected from one or more of glycerin, glycerol, coco glyceride, stearic acid, cetostearyl alcohol.
In a more preferred embodiment, the emollient of the present invention is a combination of glycerol and cetearyl alcohol, wherein the mass ratio of glycerol to cetearyl alcohol is 1: (1-3).
In a most preferred embodiment, the emollient of the present invention is a combination of glycerol and cetearyl alcohol, wherein the mass ratio of glycerol to cetearyl alcohol is 1: 1.5.
the skin-moistening cream adopts the glycerol and the cetearyl alcohol as the main components of the skin-moistening cream, so that the skin-moistening cream has good compatibility with a disinfectant system, and after the skin-moistening cream is preferably compounded with the micromolecular alcohol for use, the problem that the micromolecular alcohol causes skin chapping can be solved, the skin-moistening degree is effectively improved, the space on the surface of the skin is filled, the lipid lost in a cutin layer is replaced, the scaly skin is reduced, and the appearance of the skin is improved.
Plant essential oil
The plant essential oil is extracted from the unique aromatic substances of the plants, and is extracted from flowers, leaves, roots, barks, fruits, seeds, resins and the like of the herbaceous plants in a distillation and squeezing mode.
In a preferred embodiment, the plant essential oil of the present invention is selected from one or more of lemon essential oil, chamomile essential oil, lavender essential oil, rose essential oil, clove essential oil, and mint essential oil.
In a preferred embodiment, the plant essential oil of the present invention is chamomile essential oil.
In a most preferred embodiment, the chamomile essential oil of the invention is a roman chamomile essential oil.
The Roman chamomile essential oil has the functions of cleaning air and improving environmental pollution, and also has excellent air sterilization and disinfection effects when the fragrance of the essential oil is diffused in the air; in addition, the chamomile essential oil has excellent soothing effect, can relieve anxiety, tension, anger and fear, relax people, has tolerance and feelings of peaceful, relieves anxiety, calms mind and is very helpful to insomnia. Finally, the Roman chamomile essential oil and the emollient selected by the invention also have a synergistic effect, and the skin chapping can be prevented by the action of the Roman chamomile essential oil and the emollient; because chamomile can stimulate the production of white blood cells, act on damaged skin to resist bacteria, strengthen the immune system, smooth ruptured capillaries, improve persistent infection, improve elasticity, and protect and moisten skin.
Antibacterial agent
The antibacterial agent of the present invention refers to a chemical substance capable of maintaining the growth or reproduction of certain microorganisms (bacteria, fungi, yeasts, algae, viruses, etc.) below a necessary level for a certain period of time. An antimicrobial agent is a substance or product having bacteriostatic and bactericidal properties.
In a preferred embodiment, the antimicrobial agent of the present invention is an inorganic antimicrobial agent.
In a more preferred embodiment, the antimicrobial agent of the present invention is a nanosilver antimicrobial agent.
In a more preferred embodiment, the nano-silver antibacterial agent of the present invention has a particle size of 1 to 10 nm.
In a most preferred embodiment, the nanosilver antimicrobial agent of the present invention has a particle size of 2 nm.
The nano-silver antibacterial agent can be obtained commercially, and the manufacturer includes but is not limited to Lanfeng auxiliary agent Co., Ltd, of Foshan city, and the brand is L F-803.
The invention selects the nano-silver antibacterial agent as the antibacterial agent, on one hand, the effects of removing foams and sterilizing, resisting viruses and degrading bacteria and organic matters can be enhanced under visible light and ultraviolet light, and on the other hand, the effects of resisting bacteria and killing viruses of the disinfectant can be enhanced under the condition of no light source; in addition, the nano silver has too small particle size, is easy to agglomerate, influences the dispersibility of inorganic matters in a system, and easily influences the spraying and foaming effect of the disinfectant if the particle size is too large; through long-term experimental research, the nano-silver disinfectant with the particle size of 1-10nm is selected, the effect is optimal, and the nano-silver disinfectant is compounded with the foam stabilizer and the foaming agent, so that the compatibility among the components can be improved, the nano-silver disinfectant can be synergized with ethanol, biguanide compounds and quaternary ammonium salt compounds, and the overall sterilization and disinfection effects of the foam type household disinfectant are improved; the 1-10nm nano-silver bactericide also has excellent adsorbability, can effectively adsorb the peculiar smell in the environment, and can fundamentally purify the air by cooperating with the chamomile essential oil.
A second aspect of the present invention provides a method for preparing a foam-type home disinfectant, comprising the steps of:
(1) adding a foaming agent and a foam stabilizer into micromolecular alcohol, and stirring and dissolving to obtain a mixture A;
(2) adding a biguanide compound, a quaternary ammonium salt compound and an antibacterial agent into water, heating to 40-60 ℃, and stirring for dissolving to obtain a mixture B;
(3) cooling mixture B to room temperature, adding mixture A into mixture B, stirring at low speed for 10-15min, adding plant essential oil and emollient, and stirring at high speed.
It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention.
In addition, the raw materials used are commercially available from national chemical reagents, unless otherwise specified.
Examples
In order to better understand the above technical solutions, the following detailed descriptions will be provided with reference to specific embodiments. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention. In addition, the raw materials are commercially available and the extraction methods of the extract are all conventional extraction methods, if not otherwise specified.
Example 1
The foam type household disinfectant is characterized by comprising the following preparation raw materials in parts by weight: 10 parts of biguanide compounds, 15 parts of quaternary ammonium compounds, 3 parts of foaming agents, 8 parts of foam stabilizers, 19 parts of small molecular alcohol, 3.5 parts of emollients, 4.5 parts of plant essential oil, 4 parts of antibacterial agents and 50 parts of water.
The biguanide compound is chlorhexidine gluconate with CAS number of 18472-51-0.
The quaternary ammonium salt compound is dodecyl dimethyl benzyl ammonium bromide.
The foaming agent is a combination of tridecyl alcohol decapolyoxyethylene ether, cetyl alcohol octapolyoxyethylene ether and undecylene alcohol hexapolyoxyethylene ether, wherein the mass ratio of the tridecyl alcohol decapolyoxyethylene ether, the cetyl alcohol octapolyoxyethylene ether and the undecylene alcohol hexapolyoxyethylene ether is 1: 1.5: 0.8.
the foam stabilizer is a combination of dodecyl dimethyl amine oxide and cocamidopropyl betaine, wherein the mass ratio of the dodecyl dimethyl amine oxide to the cocamidopropyl betaine is 2: 1.
the small molecular alcohol is ethanol.
The emollient is a combination of glycerol and cetearyl alcohol, wherein the mass ratio of the glycerol to the cetearyl alcohol is 1: 1.5.
the plant essential oil is chamomile essential oil.
The chamomile essential oil is Roman chamomile essential oil.
The antibacterial agent is a nano-silver antibacterial agent.
The particle size of the nano-silver antibacterial agent is 2nm, the nano-silver antibacterial agent can be obtained commercially, and the manufacturer is Fushan blue peak auxiliary agent Co, Ltd, and the brand is L F-803.
The preparation method of the foam type household disinfectant comprises the following steps:
(1) adding a foaming agent and a foam stabilizer into micromolecular alcohol, and stirring and dissolving to obtain a mixture A;
(2) adding a biguanide compound, a quaternary ammonium salt compound and an antibacterial agent into water, heating to 45 ℃, and stirring for dissolving to obtain a mixture B;
(3) cooling the mixture B to room temperature, adding the mixture A into the mixture B, stirring at low speed for 12min, adding plant essential oil and emollient, and stirring at high speed.
Example 2
The foam type household disinfectant is characterized by comprising the following preparation raw materials in parts by weight: 5 parts of biguanide compounds, 10 parts of quaternary ammonium salt compounds, 0.1 part of foaming agents, 2 parts of foam stabilizers, 15 parts of small molecular alcohols, 1 part of emollients, 3 parts of plant essential oils, 2.3 parts of antibacterial agents and 60 parts of water.
The biguanide compound is chlorhexidine gluconate with CAS number of 18472-51-0.
The quaternary ammonium salt compound is dodecyl dimethyl benzyl ammonium bromide.
The foaming agent is a combination of tridecyl alcohol decapolyoxyethylene ether, cetyl alcohol octapolyoxyethylene ether and undecylene alcohol hexapolyoxyethylene ether, wherein the mass ratio of the tridecyl alcohol decapolyoxyethylene ether, the cetyl alcohol octapolyoxyethylene ether and the undecylene alcohol hexapolyoxyethylene ether is 1: 1.5: 0.8.
the foam stabilizer is a combination of dodecyl dimethyl amine oxide and cocamidopropyl betaine, wherein the mass ratio of the dodecyl dimethyl amine oxide to the cocamidopropyl betaine is 2: 1.
the small molecular alcohol is ethanol.
The emollient is a combination of glycerol and cetearyl alcohol, wherein the mass ratio of the glycerol to the cetearyl alcohol is 1: 1.5.
the plant essential oil is chamomile essential oil.
The chamomile essential oil is Roman chamomile essential oil.
The antibacterial agent is a nano-silver antibacterial agent.
The particle size of the nano-silver antibacterial agent is 2nm, the nano-silver antibacterial agent can be obtained commercially, and the manufacturer is Fushan blue peak auxiliary agent Co, Ltd, and the brand is L F-803.
The preparation method of the foam type household disinfectant comprises the following steps:
(1) adding a foaming agent and a foam stabilizer into micromolecular alcohol, and stirring and dissolving to obtain a mixture A;
(2) adding a biguanide compound, a quaternary ammonium salt compound and an antibacterial agent into water, heating to 45 ℃, and stirring for dissolving to obtain a mixture B;
(3) cooling the mixture B to room temperature, adding the mixture A into the mixture B, stirring at low speed for 12min, adding plant essential oil and emollient, and stirring at high speed.
Example 3
The foam type household disinfectant is characterized by comprising the following preparation raw materials in parts by weight: 15 parts of biguanide compounds, 20 parts of quaternary ammonium compounds, 3.5 parts of foaming agents, 6 parts of foam stabilizers, 25 parts of micromolecular alcohol, 5 parts of emollients, 6 parts of plant essential oil, 5.8 parts of antibacterial agents and 80 parts of water.
The biguanide compound is chlorhexidine gluconate with CAS number of 18472-51-0.
The quaternary ammonium salt compound is dodecyl dimethyl benzyl ammonium bromide.
The foaming agent is a combination of tridecyl alcohol decapolyoxyethylene ether, cetyl alcohol octapolyoxyethylene ether and undecylene alcohol hexapolyoxyethylene ether, wherein the mass ratio of the tridecyl alcohol decapolyoxyethylene ether, the cetyl alcohol octapolyoxyethylene ether and the undecylene alcohol hexapolyoxyethylene ether is 1: 1.5: 0.8.
the foam stabilizer is a combination of dodecyl dimethyl amine oxide and cocamidopropyl betaine, wherein the mass ratio of the dodecyl dimethyl amine oxide to the cocamidopropyl betaine is 2: 1.
the small molecular alcohol is ethanol.
The emollient is a combination of glycerol and cetearyl alcohol, wherein the mass ratio of the glycerol to the cetearyl alcohol is 1: 1.5.
the plant essential oil is chamomile essential oil.
The chamomile essential oil is Roman chamomile essential oil.
The antibacterial agent is a nano-silver antibacterial agent.
The particle size of the nano-silver antibacterial agent is 2nm, the nano-silver antibacterial agent can be obtained commercially, and the manufacturer is Fushan blue peak auxiliary agent Co, Ltd, and the brand is L F-803.
The preparation method of the foam type household disinfectant comprises the following steps:
(1) adding a foaming agent and a foam stabilizer into micromolecular alcohol, and stirring and dissolving to obtain a mixture A;
(2) adding a biguanide compound, a quaternary ammonium salt compound and an antibacterial agent into water, heating to 45 ℃, and stirring for dissolving to obtain a mixture B;
(3) cooling the mixture B to room temperature, adding the mixture A into the mixture B, stirring at low speed for 12min, adding plant essential oil and emollient, and stirring at high speed.
Example 4
Similar to example 1, except that the blowing agent isooctanol polyoxyethylene ether.
Example 5
Similar to example 1, except that the blowing agent is free of tridecyl alcohol decapolyoxyethylene ether.
Example 6
Similar to example 1, except that the blowing agent is free of cetyl alcohol octapolyoxyethylene ether.
Example 7
Similar to example 1, except that the blowing agent is free of undecylenic alcohol hexa polyoxyethylene ether.
Example 8
Similar to example 1, except that the foam stabilizer is dodecyl dimethyl amine oxide.
Example 9
Similar to example 1, except that the foam stabilizer is cocamidopropyl betaine.
Example 10
Similar to example 1, except that the foam stabilizer is lauric acid diethanolamide.
Evaluation of Performance
1. Low-temperature stability: the foam type home disinfectants prepared in examples 1 to 7 were placed in an incubator at-10 c for 6 months under the conditions, and the appearance of the foam type home disinfectants was observed for any abnormality at 0, 1, 3, 4, and 6 months, respectively, and the results are shown in table 1 below.
TABLE 1 disinfectant appearance Condition
2. Low-temperature sterilization test, namely, carrying out a carrier soaking quantitative sterilization test on the foam type household disinfectants provided by the examples 1-3 and 8-10, wherein the experimental bacteria are respectively staphylococcus aureus (ATCC6538), escherichia coli (8099) and candida albicans (ATCC 10231). according to the dosage of one bacterial sheet 5.0m L, the foam type household disinfectants provided by the examples 1-3 and 8-10 are respectively added into a sterile plate, then the bacterial sheets are added, the action is carried out for 5min at the temperature of minus 10 ℃, the bacterial sheets are moved into a test tube filled with 5.0m L neutralizing agent, the neutralization is carried out for 10min, the test tube is knocked 80 times to elute the bacteria on the bacterial sheets and uniformly mix, the eluent 5.0m L is taken for live counting, and the killing rate is calculated, and the obtained results are shown in Table 2.
TABLE 2 Sterilization Property test data
The foregoing examples are merely illustrative and serve to explain some of the features of the method of the present invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. Also, where numerical ranges are used in the claims, subranges therein are included, and variations in these ranges are also to be construed as possible being covered by the appended claims.
Claims (10)
1. A foam type household disinfectant is characterized by comprising the following preparation raw materials in parts by weight: 5-15 parts of biguanide compounds, 10-20 parts of quaternary ammonium salt compounds, 0.1-3.5 parts of foaming agents, 2-6 parts of foam stabilizers, 15-25 parts of small molecular alcohols, 1-5 parts of emollients, 3-6 parts of plant essential oil, 2.3-5.8 parts of antibacterial agents and 60-80 parts of water.
2. The foam-type household disinfectant according to claim 1, wherein said plant essential oil is selected from one or more of lemon essential oil, chamomile essential oil, lavender essential oil, rose essential oil, clove essential oil and mint essential oil.
3. Foam-type domestic disinfectant according to claim 1, wherein said quaternary ammonium salt-based compound is a single chain quaternary ammonium compound.
4. The foam-type household disinfectant according to claim 1, wherein said foaming agent is an alkyl alcohol ether.
5. Foam-type domestic disinfectant according to claim 4, wherein the carbon chain length in said alkyl alcohol ether is C10-C16.
6. Foam-type domestic disinfectant according to claim 1, wherein said foam stabilizer is a nitrogen-containing amphoteric surfactant or a nitrogen-containing nonionic surfactant.
7. Foam-type domestic disinfectant according to claim 1, wherein said antimicrobial agent is an inorganic antimicrobial agent.
8. Foam-type domestic disinfectant according to claim 1 or 7, wherein said antimicrobial agent is a nano silver antimicrobial agent.
9. The foam-type disinfectant for home use according to claim 8, wherein said nano silver antibacterial agent has a particle size of 1-10 nm.
10. A method for preparing a foam-type household disinfectant according to any one of claims 1 to 9, wherein said method comprises the steps of:
(1) adding a foaming agent and a foam stabilizer into micromolecular alcohol, and stirring and dissolving to obtain a mixture A;
(2) adding a biguanide compound, a quaternary ammonium salt compound and an antibacterial agent into water, heating to 40-60 ℃, and stirring for dissolving to obtain a mixture B;
(3) cooling mixture B to room temperature, adding mixture A into mixture B, stirring at low speed for 10-15min, adding plant essential oil and emollient, and stirring at high speed.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115350317A (en) * | 2022-08-30 | 2022-11-18 | 振德医疗用品股份有限公司 | Wound dressing composition and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115350317A (en) * | 2022-08-30 | 2022-11-18 | 振德医疗用品股份有限公司 | Wound dressing composition and preparation method thereof |
| CN115350317B (en) * | 2022-08-30 | 2024-04-02 | 振德医疗用品股份有限公司 | Wound dressing composition and preparation method thereof |
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