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CN111481164B - Method and device for acquiring fluorescence fundus picture - Google Patents

Method and device for acquiring fluorescence fundus picture Download PDF

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CN111481164B
CN111481164B CN201910071313.9A CN201910071313A CN111481164B CN 111481164 B CN111481164 B CN 111481164B CN 201910071313 A CN201910071313 A CN 201910071313A CN 111481164 B CN111481164 B CN 111481164B
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fundus image
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CN111481164A (en
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陈名科
蔡金翰
谢易庭
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Xie Yiting
Acer Inc
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes

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Abstract

The method for acquiring a fluorescence fundus image of the invention comprises the following steps: receiving a color eye fundus picture to be detected; acquiring color image characteristics of a color eye background image to be detected; coding the color image characteristics of the color eye fundus map to be detected according to the eye fundus image map conversion model, and converting the color eye fundus map to be detected into a fluorescence eye fundus map to be detected; and outputting a fluorescence fundus map.

Description

用以获取荧光眼底图的方法及其装置Method and device for obtaining fluorescein fundus map

技术领域technical field

本发明涉及一种人体检测技术，尤其涉及一种用以获取荧光眼底图的方法及其装置。The invention relates to a human body detection technology, in particular to a method and a device for obtaining a fluorescein fundus image.

背景技术Background technique

荧光眼底摄影被应用于检查眼睛后面的血管性病变，例如，糖尿病视网膜症、血管阻塞性变化、黄斑部病变等。虽然荧光眼底摄影为现阶段最精确诊断血管性病变的手法，但因需要散瞳剂及荧光剂的辅助，受测者需要等候散瞳剂及荧光剂在人体发挥效果后才能够进行荧光眼底摄影，导致每次受测所需的时间相当长。不仅如此，由于荧光剂的化学作用，受测者伴随着恶心、呕吐、过敏，甚至是过敏性休克的风险，因此，虽然荧光眼底摄影的精确度较高，但并非眼科检查首选。基此，如何能够提供精确的图像分析，同时又避免受测者的久候与不适为本领域技术人员所致力的课题。Fluorescein fundus photography is used to check for vascular lesions at the back of the eye, eg, diabetic retinopathy, vaso-occlusive changes, macular degeneration, etc. Although fluorescein fundus photography is the most accurate method for diagnosing vascular lesions at the present stage, due to the need for mydriatics and fluorescent agents, the subjects need to wait for the effects of mydriatics and fluorescers on the human body before performing fluorescein fundus photography , resulting in a rather long time required for each test. Not only that, due to the chemical action of the fluorescent agent, the subject is accompanied by the risk of nausea, vomiting, allergies, and even anaphylactic shock. Therefore, although the accuracy of fluorescent fundus photography is high, it is not the first choice for ophthalmological examination. Based on this, how to provide accurate image analysis while avoiding the long-term waiting and discomfort of the subject is a subject for those skilled in the art.

发明内容Contents of the invention

本发明提供一种用以获取荧光眼底图的方法及其装置，以将彩色眼底图转换成荧光眼底图，以使受测者无需经历荧光眼底摄影久候且不适的情形。The present invention provides a method and device for obtaining a fluorescein fundus image, so as to convert the color fundus image into a fluorescein fundus image, so that the subject does not need to experience the long-term waiting and uncomfortable situation of the fluorescein fundus photography.

本发明的用以获取荧光眼底图的方法具有下列步骤：接收待测彩色眼底图；获取待测彩色眼底图的彩图特征；依据眼底图像图转换模型编码待测彩色眼底图的彩图特征，以转换待测彩色眼底图为待测荧光眼底图；以及输出荧光眼底图。The method for obtaining the fluorescent fundus map of the present invention has the following steps: receiving the color fundus map to be tested; obtaining the color map features of the color fundus map to be tested; encoding the color map features of the color fundus map to be tested according to the fundus image map conversion model, Converting the color fundus image to be tested into the fluorescence fundus image to be tested; and outputting the fluorescence fundus image.

本发明的用以获取荧光眼底图的装置具有输入单元、存储单元以及处理单元。输入单元接收待测彩色眼底图。存储单元存储眼底图像图转换模型。处理单元连接输入单元及存储单元。处理单元还获取待测彩色眼底图的彩图特征，依据眼底图像图转换模型编码待测彩色眼底图的彩图特征，以转换待测彩色眼底图为待测荧光眼底图，并输出荧光眼底图。The device for obtaining a fluorescein fundus image of the present invention has an input unit, a storage unit and a processing unit. The input unit receives the color fundus image to be measured. The storage unit stores the fundus image map conversion model. The processing unit is connected to the input unit and the storage unit. The processing unit also obtains the color map features of the color fundus map to be tested, encodes the color map features of the color fundus map to be tested according to the fundus image map conversion model, converts the color fundus map to be tested into the fluorescent fundus map to be tested, and outputs the fluorescent fundus map .

基于上述，本发明的用以获取荧光眼底图的方法及用以获取荧光眼底图的装置能够将待测彩色眼底图通过编码的方式转换为而将彩色眼底图转变为荧光眼底图。因此，受测者仅须通过拍摄待测彩色眼底图即可获取相应的荧光眼底图，无需经过冗长的荧光眼底摄影程序，亦无需忍受荧光剂所带来的不适。Based on the above, the method and device for obtaining a fluorescein fundus map of the present invention can convert the color fundus map to be measured into a fluorescein fundus map by encoding. Therefore, the subject can obtain the corresponding fluorescent fundus image only by taking the color fundus image to be tested, without going through a lengthy procedure of fluorescent fundus photography, and without having to endure the discomfort caused by the fluorescent agent.

为让本发明的上述特征和优点能更明显易懂，下文特举实施例，并配合附图作详细说明如下。In order to make the above-mentioned features and advantages of the present invention more comprehensible, the following specific embodiments are described in detail with reference to the accompanying drawings.

附图说明Description of drawings

图1示出本发明一实施例用以获取荧光眼底图的装置的示意图；FIG. 1 shows a schematic diagram of a device for obtaining a fluorescein fundus image according to an embodiment of the present invention;

图2示出本发明一实施例用以获取荧光眼底图的方法的流程示意图；Fig. 2 shows a schematic flow chart of a method for obtaining a fluorescein fundus image according to an embodiment of the present invention;

图3示出本发明一实施例获取眼底图像图转换模型的方法的流程示意图。Fig. 3 shows a schematic flowchart of a method for obtaining a fundus image map conversion model according to an embodiment of the present invention.

附图标号说明：Explanation of reference numbers:

100：用以获取荧光眼底图的装置100: Apparatus for obtaining a fluorescein fundus map

110：输入单元110: input unit

120：存储单元120: storage unit

130：处理单元130: processing unit

S210～S240、S310～S330：步骤S210～S240, S310～S330: steps

具体实施方式Detailed ways

在下述的实施例中，彩色眼底图、待测彩色眼底图指的是在不施打荧光剂的情形下所拍摄相应人体眼底的彩色图像。荧光眼底图指的是在施打荧光剂的情形下所拍摄相应人体眼底的图像。In the following embodiments, the color fundus image and the color fundus image to be tested refer to the color image of the corresponding human fundus captured without applying fluorescent agent. The fundus fluorescein map refers to the image of the corresponding human fundus taken under the condition of applying a fluorescent agent.

图1示出本发明一实施例获取荧光眼底图的装置的示意图。请参照图1，用以获取荧光眼底图的装置100至少具有输入单元110、存储单元120以及处理单元130。Fig. 1 shows a schematic diagram of a device for obtaining a fluorescein fundus image according to an embodiment of the present invention. Referring to FIG. 1 , the device 100 for obtaining a fluorescein fundus image at least has an input unit 110 , a storage unit 120 and a processing unit 130 .

输入单元110接收待测彩色眼底图。在本发明的一实施例中，输入单元110能够以眼底摄影机实现，即通过拍摄待测者眼底的相片而接收待测彩色眼底图。在本发明的另一实施例中，输入单元110可以采用接收数字数据传输的连接端口所实现，例如，支援各类型通讯协定的RS-232接口、通用序列汇流排(Universal Serial Bus，USB)、无线保真接口(Wireless fidelity，WiFi)、RJ45接口等，然本发明不限于此。也就是说，获取荧光眼底图的装置100可以通过输入单元110直接拍摄或间接地通过传输接收待测彩色眼底图，本发明不限于此。The input unit 110 receives the color fundus image to be measured. In an embodiment of the present invention, the input unit 110 can be realized by a fundus camera, that is, the color fundus map to be tested can be received by taking a photo of the fundus of the subject to be tested. In another embodiment of the present invention, the input unit 110 can be realized by a connection port for receiving digital data transmission, for example, an RS-232 interface supporting various types of communication protocols, a universal serial bus (Universal Serial Bus, USB), Wireless fidelity interface (Wireless fidelity, WiFi), RJ45 interface, etc., but the present invention is not limited thereto. That is to say, the apparatus 100 for obtaining a fluorescein fundus image may directly capture the color fundus image to be measured through the input unit 110 or indirectly receive the color fundus image to be measured through transmission, and the present invention is not limited thereto.

存储单元120用以存储用以获取荧光眼底图的装置100运行所需的各类数据及程序码。特别是，存储单元120会存储眼底图像图转换模型，且此眼底图像图转换模型具有将彩色眼底图转换成相应的荧光眼底图的参数。在本发明的一实施例中，存储单元120的硬件可以为各类型非易失性存储器，例如硬盘机(hard disk drive；HDD)以及固态磁盘机(solid-state drive；SSD)等类型的存储装置，然本发明不限于此。The storage unit 120 is used for storing various data and program codes required for the operation of the apparatus 100 for obtaining a fluorescein fundus image. In particular, the storage unit 120 stores a fundus image map conversion model, and the fundus image map conversion model has parameters for converting a color fundus map into a corresponding fluorescence fundus map. In an embodiment of the present invention, the hardware of the storage unit 120 can be various types of non-volatile memory, such as hard disk drive (hard disk drive; HDD) and solid-state disk drive (solid-state drive; SSD) and other types of storage. device, but the present invention is not limited thereto.

处理单元130连接于输入单元110以及存储单元120，并用以执行用以获取荧光眼底图的装置100运行所需的各类运算。详细的运算将于后方再进行说明。在本发明的一实施例中，处理单元130例如为中央处理单元(Central Processing Unit，CPU)、微处理器(Microprocessor)、数字信号处理器(Digital Signal Processor，DSP)、可程序化控制器、可程序化逻辑装置(Programmable Logic Device，PLD)或其他类似装置或这些装置的组合，本发明不限于此。The processing unit 130 is connected to the input unit 110 and the storage unit 120, and is used to execute various calculations required for the operation of the device 100 for obtaining a fluorescein fundus map. The detailed operation will be described later. In an embodiment of the present invention, the processing unit 130 is, for example, a central processing unit (Central Processing Unit, CPU), a microprocessor (Microprocessor), a digital signal processor (Digital Signal Processor, DSP), a programmable controller, Programmable Logic Device (Programmable Logic Device, PLD) or other similar devices or a combination of these devices, the present invention is not limited thereto.

图2示出本发明一实施例用以获取荧光眼底图的方法的流程示意图。请参照图2，此实施例的用以获取荧光眼底图的方法至少适用于图1所示出用以获取荧光眼底图的装置100，然不限于此。以下将通过图1和图2来说明用以获取荧光眼底图的方法的细节。FIG. 2 shows a schematic flowchart of a method for obtaining a fluorescein fundus image according to an embodiment of the present invention. Please refer to FIG. 2 , the method for obtaining a fluorescein fundus image in this embodiment is at least applicable to the device 100 for obtaining a fluorescein fundus image shown in FIG. 1 , but is not limited thereto. The details of the method for obtaining a fluorescein fundus map will be described below with reference to FIG. 1 and FIG. 2 .

在步骤S210，由输入单元110接收待测彩色眼底图。具体来说，如同前述，输入单元110可以通过拍摄人体眼底，或者是通过传输的方式接收欲进行诊断的待测彩色眼底图。In step S210, the input unit 110 receives the color fundus image to be measured. Specifically, as mentioned above, the input unit 110 may receive the color fundus image to be tested for diagnosis by photographing the fundus of the human body, or through transmission.

在步骤S220，由处理单元130获取待测彩色眼底图的彩图特征。值得一提的是，在本发明的一实施例中，为了在获取彩图特征时能够快速且精确，处理单元130还会进一步对待测彩色眼底图执行预处理程序。举例来说，预处理程序例如为灰阶处理、眼球定位以及图像强化中的至少一个。In step S220, the processing unit 130 acquires the color map features of the color fundus map to be tested. It is worth mentioning that, in an embodiment of the present invention, in order to obtain the features of the color image quickly and accurately, the processing unit 130 will further execute a preprocessing program on the color fundus image to be tested. For example, the preprocessing procedure is at least one of gray scale processing, eye positioning and image enhancement.

灰阶处理是将图像转换成灰阶，以使转换像素后的图像特征能够被突显出来。眼球定位是先识别使用者眼球的位置，藉此以滤除不属于眼底的范围。图像强化例如是，采用高斯滤波器对图像进行平滑化处理。Grayscale processing is to convert the image into grayscale, so that the image features after the converted pixels can be highlighted. Eye positioning is to identify the position of the user's eyeballs first, so as to filter out the range that does not belong to the fundus. Image enhancement is, for example, smoothing an image using a Gaussian filter.

在步骤S230，由处理单元130依据存储单元120中的眼底图像图转换模型编码待测彩色眼底图的彩图特征，以转换待测彩色眼底图为待测荧光眼底图。由于眼底图像图转换模型具有将彩色眼底图转换为荧光眼底图的参数及规则，因此，处理单元130能够依据眼底图像图转换模型对待测彩色眼底图的彩图特征进行编码，藉此，以输出相应的荧光眼底图。In step S230, the processing unit 130 encodes the color image features of the color fundus image to be tested according to the fundus image image conversion model in the storage unit 120, so as to convert the color fundus image to be tested into a fluorescent fundus image to be tested. Since the fundus image conversion model has parameters and rules for converting a color fundus image into a fluorescent fundus image, the processing unit 130 can encode the color map features of the color fundus image to be tested according to the fundus image conversion model, thereby outputting Corresponding fluorescein fundus map.

在步骤S240，由处理单元130输出荧光眼底图。藉此，医护人员能够通过输出的荧光眼底图判断被测者的眼底是否相应于潜在疾病的眼底情形，进而对被测者进行治疗。In step S240 , the processing unit 130 outputs a fluorescein fundus map. In this way, the medical staff can judge whether the fundus of the subject corresponds to the condition of the fundus of the potential disease through the output fluorescein fundus image, and then treat the subject.

值得一提的是，在本发明的部分实施例中，存储单元120还能够进一步存储与疾病相关的荧光图特征。基此，处理单元130还能够在获取荧光眼底图的荧光图特征时，自动依据荧光图特征判断荧光眼底图相应的疾病信息。It is worth mentioning that, in some embodiments of the present invention, the storage unit 120 can further store disease-related fluorescence map features. Based on this, the processing unit 130 can also automatically determine the disease information corresponding to the fluorescein fundus image according to the fluorescein image feature when acquiring the fluorescein image feature of the fluorescein fundus image.

图3示出本发明一实施例获取眼底图像图转换模型的方法的流程示意图。以下将通过图1及图3说明获取眼底图像图转换模型的方法。Fig. 3 shows a schematic flowchart of a method for obtaining a fundus image map conversion model according to an embodiment of the present invention. The method for obtaining the conversion model of the fundus image map will be described below with reference to FIG. 1 and FIG. 3 .

在步骤S310，由输入单元110接收彩色眼底图以及相应的荧光眼底图。具体来说，输入单元110所接收的彩色眼底图及荧光眼底图是相应于同一个受测者的测量结果。也就是说，彩色眼底图及荧光眼底图都是历史上实际所检测出的信息。In step S310 , the color fundus map and the corresponding fluorescein fundus map are received by the input unit 110 . Specifically, the color fundus image and the fluorescence fundus image received by the input unit 110 correspond to the measurement results of the same subject. That is to say, both the color fundus map and the fluorescein fundus map are actually detected information in history.

在步骤S320，由处理单元130获取彩色眼底图中的彩图特征，编码彩色眼底图的彩图特征，以将彩色眼底图转换为预估荧光眼底图。在本发明的一实施例中，处理单元130是依据自编码网络(Autoencoder)编码彩色眼底图的彩图特征，然本发明并不限于此。In step S320, the processing unit 130 acquires the color map features of the color fundus map, encodes the color map features of the color fundus map, and converts the color fundus map into an estimated fluorescence fundus map. In an embodiment of the present invention, the processing unit 130 encodes the color image features of the color fundus image according to an autoencoder network (Autoencoder), but the present invention is not limited thereto.

除此之外，为了减少编码所耗费的时间，处理单元130也会对彩色眼底图中执行预处理程序。预处理程序的内容已在上方说明，于此即不再赘述。In addition, in order to reduce the time spent on encoding, the processing unit 130 also executes a preprocessing procedure on the color fundus image. The content of the preprocessing procedure has been described above, and will not be repeated here.

在步骤S330，由处理单元130比较预估荧光眼底图中的荧光图像特征及荧光眼底图的荧光图像特征，以获取差异特征信息，并依据差异特征信息训练眼底图像图转换模型。In step S330, the processing unit 130 compares the fluorescence image features of the estimated fundus fundus image with the fluorescence image features of the fundus fundus image to obtain difference feature information, and trains a fundus image conversion model based on the difference feature information.

也就是说，由于彩色眼底图和荧光眼底图是相应于同一个受测者，在不考虑图像的识别度、摄影机精细度等各类外在因素的情形下，理论上同一个受测者接受任何测试所产生的眼底图会是一样的。基此，通过眼底图像图转换模型，彩色眼底图经过编码后所产生的预估荧光眼底图应与荧光眼底图具备相同的荧光图像特征。因此，处理单元130可以判断荧光眼底图与荧光眼底图之间的差异以获取差异特征信息，并通过差异特征信息调整编码造成的误差，训练及调整眼底图像图转换模型。That is to say, since the color fundus map and the fluorescein fundus map correspond to the same subject, in theory, the same subject accepts The fundus map produced by any test will be the same. Based on this, through the fundus image map conversion model, the estimated fluorescent fundus map generated by encoding the color fundus map should have the same fluorescence image characteristics as the fluorescent fundus map. Therefore, the processing unit 130 can judge the difference between the fundus fluorescein map and the fundus fluorescein map to obtain the difference feature information, and adjust the error caused by encoding by using the difference feature information to train and adjust the fundus image conversion model.

值得一提的是，在训练眼底图像图转换模型的初期，由于眼底图像图转换模型在彩色眼底图与荧光眼底图中转换的参数与规则尚未明确，使得转换后的预估荧光眼底图与荧光眼底图差异较大。此时，处理单元130会采取小规模的方式进行编码，例如，以彩图特征或是一个区域为基准而进行编码。而在后期训练的时候，因彩色眼底图与荧光眼底图之间的参数与规则较明确，处理单元130能够以大规模的方式进行编码，例如对整个彩色眼底图进行编码，以提升学习效率。然本发明不限于此。It is worth mentioning that in the early stage of training the fundus image conversion model, the parameters and rules for the conversion of the fundus image conversion model between color fundus and fluorescence Fundus maps vary widely. At this time, the processing unit 130 will perform encoding in a small-scale manner, for example, encoding based on a color map feature or a region. In the later stage of training, because the parameters and rules between the color fundus map and the fluorescence fundus map are relatively clear, the processing unit 130 can encode in a large-scale manner, for example, encode the entire color fundus map to improve learning efficiency. However, the present invention is not limited thereto.

综上所述，本发明发明的用以获取荧光眼底图的方法及用以获取荧光眼底图的装置能够将待测彩色眼底图通过编码的方式转换为而将彩色眼底图转变为荧光眼底图。因此，受测者仅须通过拍摄待测彩色眼底图即可获取相应的荧光眼底图，无需经过冗长的荧光眼底摄影程序，亦无需忍受荧光剂所带来的不适。To sum up, the method for obtaining a fundus fundus image and the device for obtaining a fundus fundus image of the present invention can convert the color fundus image to be measured into a fundus image by coding. Therefore, the subject can obtain the corresponding fluorescent fundus image only by taking the color fundus image to be tested, without going through a lengthy procedure of fluorescent fundus photography, and without having to endure the discomfort caused by the fluorescent agent.

虽然本发明已以实施例揭示如上，然其并非用以限定本发明，任何所属技术领域中技术人员，在不脱离本发明的精神和范围内，当可作些许的更改与润饰，故本发明的保护范围当视权利要求所界定的为准。Although the present invention has been disclosed above with the embodiments, it is not intended to limit the present invention. Any person skilled in the art can make some changes and modifications without departing from the spirit and scope of the present invention. Therefore, the present invention The scope of protection shall prevail as defined by the claims.

Claims (8)

1. A method to acquire a fluorescence fundus map, comprising:
receiving a color eye fundus picture to be detected;
acquiring color image characteristics of the color eye background image to be detected;
coding the color image characteristics of the color eye-fundus picture to be detected according to an eye fundus image picture conversion model so as to convert the color eye-fundus picture to be detected into a fluorescence eye-fundus picture to be detected, wherein the coding of the color image characteristics of the color eye-fundus picture to be detected according to the eye fundus image picture conversion model so as to convert the color eye-fundus picture to be detected into the fluorescence eye-fundus picture to be detected comprises the following steps:
receiving a color fundus map and a corresponding fluorescence fundus map;
acquiring color image features in the color eye fundus image;
coding the color image characteristics of the color fundus image to convert the color fundus image into an estimated fluorescence fundus image;
comparing the fluorescent image characteristics in the estimated fluorescent fundus image with the fluorescent image characteristics of the fluorescent fundus image to acquire difference characteristic information; and
training the fundus image map conversion model according to the difference characteristic information; and
and outputting the fluorescence fundus map.
2. The method of claim 1, wherein the step of encoding the color map features comprises:
and coding the color image characteristics of the color eye bottom image according to a self-coding network.
3. The method for acquiring a fluorescence fundus map of claim 1, further comprising:
and executing a preprocessing program on at least one of the color eye base image to be detected and the color eye base image, wherein the preprocessing program comprises at least one of gray scale processing, eyeball positioning and image enhancement.
4. The method for acquiring a fluorescence fundus map of claim 1, further comprising:
and acquiring the fluorescence image characteristics of the fluorescence fundus image, and judging the corresponding disease information of the fluorescence fundus image according to the fluorescence image characteristics.
5. An apparatus for acquiring a fluorescence fundus image, comprising:
the input unit is used for receiving the color eye fundus diagram to be detected;
a storage unit which stores the fundus image conversion model; and
a processing unit connected to the input unit and the storage unit, wherein,
the processing unit further acquires color image features of the color fundus image to be detected, encodes the color image features of the color fundus image to be detected according to the fundus image conversion model, and converts the color fundus image to be detected into a fluorescence fundus image to be detected, wherein the input unit further receives the color fundus image and a corresponding fluorescence fundus image, the processing unit further acquires color image features in the color fundus image, encodes color image features of the color fundus image, so as to convert the color fundus image into an estimated fluorescence fundus image, the processing unit further compares fluorescence image features in the estimated fluorescence fundus image with fluorescence image features of the fluorescence fundus image, so as to acquire difference feature information, and trains the fundus image conversion model according to the difference feature information,
wherein the processing unit outputs the fluorescence fundus map.
6. The apparatus for acquiring a fluorescence fundus image of claim 5, wherein,
the processing unit encodes the color image features of the color eye-bottom image according to a self-encoding network.
7. The apparatus for acquiring a fluorescence fundus image of claim 5, wherein,
the processing unit further executes a preprocessing program on at least one of the color eye fundus image to be detected and the color eye fundus image, wherein the preprocessing program comprises at least one of gray scale processing, eyeball positioning and image strengthening.
8. The apparatus for acquiring a fluorescence fundus image of claim 5, wherein,
the processing unit also acquires the fluorescence image characteristics of the fluorescence fundus image and judges the corresponding disease information of the fluorescence fundus image according to the fluorescence image characteristics.
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