CN111467231A - A kind of closed-type compounding device for antitumor drug and using method thereof - Google Patents

Abstract

The invention relates to the field of medical devices, and discloses a closed-type compounding device for antitumor drugs and a method for using the same. ; A connecting tube is fixed in the middle of the top of the cap, and an injection needle tube is coaxially arranged near the end of the connecting tube of the cap, and the needle tip of the injection needle tube passes through the top cover of the cap and extends to the middle of the cylinder; the connecting tube away from the cap The end is provided with a needle plug, and both the injection needle tube and the needle plug are communicated with the inner cavity of the connecting tube. In the present invention, the vial is inserted into the cylinder and the injection needle tube inside the cap is inserted into the vial, the flange in the cylinder is used to clamp the neck of the vial, the solvent liquid is injected into the vial through the injection needle, and then the cylinder is held by hand. Body shakes the medicine in the vial, which can prevent the liquid in the vial from splashing into the air during the process, prevent the drug from damaging the mucous membrane or skin of the medical staff, and avoid the occurrence of needle stick injuries.

Description

A kind of closed-type compounding device for antitumor drug and using method thereof

technical field

The invention relates to the field of medical devices, in particular to a closed-type compounding device for antitumor drugs and a method for using the same.

Background technique

The vial is a small glass container used to hold powder or liquid medicine. Its structure includes a bottle body, a bottle head, and a neck located in the concave part between the bottle body and the bottle head. The capacity is generally 1-20ml. It is generally used for For injection of medicinal liquid or medicinal powder, the cap of the bottle head is generally made of rubber as a rubber stopper, and a layer of metal aluminum foil is also set outside the rubber stopper to seal.

At present, when using traditional dispensing methods to prepare antitumor drugs in vials, a syringe is generally used to draw the solvent from the infusion bag or infusion bottle, and then the needle of the syringe is inserted into the vial to inject the drug into the vial, and the vial is manually held by hand. Shake the liquid in the bottle from side to side, then insert the needle into the vial and invert the vial, and suck out the liquid in the vial; after the suction is completed, inject the liquid in the syringe into the infusion bag, and pull out the syringe , and finally complete the transfer and dispensing of the medicinal liquid or medicinal powder in the vial. This dispensing method of manually injecting and sucking the medicinal liquid or medicinal powder in the vial by using a hand-held syringe, then inserting the syringe into the infusion bag and injecting the medicinal liquid into the infusion bag, has complicated operation steps, time-consuming and inefficient, and the hand-held syringe is not effective for the vial. The way in which suction is performed or the infusion bag is filled carries the risk of needle stick injuries and the dispersion of drug molecules in the air, exposing medical personnel to it. According to relevant literature records, chemotherapy drugs, in particular, are harmful to normal human skin and mucous membranes, bone marrow cells, reproductive system, etc. In addition, the cost of configuring biological dispensing cabinets is extremely high, resulting in a low penetration rate and other factors. To sum up, in the long term, the exposure of antitumor drug molecules has caused immeasurable harm to medical staff.

According to the World Health Organization's Global Oncology Report 2014, healthcare workers face the risk of exposure to dangerous drugs while caring for patients. It is estimated that by 2015, 10.69 million healthcare workers in China will be at risk of exposure to dangerous drugs. In 2016, the United States Pharmacopeia Congress made detailed regulations on the handling of dangerous drugs, and in 2018, it was officially included in the occupational safety program. The United States requires that all dispensing systems should use a closed-system drug transfer device (CSTD) as much as possible in 2018. At present, the commonly used CSTD abroad are: PhaSeal ( ^BiansiTM ), Chemoclave, Chemoprotect, Halo system, etc. These devices have been proved to help reduce the pollution of anti-tumor drugs. Among them, the American BD PhaSeal ( ^BiansiTM ) system has The most widely studied, however, the system is expensive and cumbersome to operate. In addition, according to the "Clinical Practice Guidelines for Hepatocyte Transarterial Chemoembolization in China" issued by the Interventional Physician Branch of the Chinese Medical Doctor Association in 2019, it is proposed that hepatocellular carcinoma (HCC) is a malignant tumor originating from hepatocytes, and 80% of Chinese HCC patients occur. after hepatitis B virus (HBV) infection. HCC is usually a tumor with a rich blood supply. Transarterial chemoembolization (TACE) treatment on the one hand blocks the blood supply of the tumor, and at the same time accumulates highly concentrated chemotherapeutic drugs locally in the tumor, which exerts the maximum killing effect on tumor cells. It is recognized that It is one of the common methods for non-surgical treatment of HCC. Therefore, with the same efficacy, a more economical and more convenient CSTD will undoubtedly reduce the economic burden of TACE surgery for liver cancer patients in my country and reduce the work of tumor-related medical staff to formulate anti-tumor drugs. Mental and physical burden. Therefore, it is urgent to propose this economical disposable anti-tumor drug closed-type compounding device with Chinese characteristics.

SUMMARY OF THE INVENTION

Based on the above problems, the present invention provides a closed-type compounding device for antitumor drugs and a method for using the same. The edge of the bottle is stuck at the neck of the vial, and the solvent liquid is injected into the vial through the injection needle, and then the medicine in the vial is shaken by the cylinder. The injury of mucous membranes or skin of medical staff also avoids the occurrence of needle stick injuries.

For solving the above-mentioned technical problems, the technical scheme adopted in the present invention is:

A closed-type compounding device for antitumor drugs, comprising a cylinder with open ends at both ends and an inner diameter larger than the outer diameter of the vial, one end of the cylinder is provided with a cap that can cover the end of the cylinder, and the cylinder is The inner wall of the body is provided with a flange that can clamp the bottle neck of the cylin, the flange is located near the end of the cylinder with a cap, and the flange is made of elastic material; one end of the cap is open, and the other end is provided with a top cover , a connecting tube is fixed in the middle of the top of the cap; the end of the connecting tube near the cap is coaxially provided with an injection needle, the central axis of the injection needle and the central axis of the barrel are on the same line, and the needle tip of the injection needle passes through the cap. The top cover extends to the middle of the barrel; the end of the connecting pipe far from the cap is provided with a needle plug that can be sleeved with the nipple of the syringe, and the injection needle and the needle plug are both communicated with the inner cavity of the connecting pipe.

Further, the position of the inner wall of the cap close to the top cover is provided with a constricted section, and the position of the inner wall of the cap close to the opening is provided with an internal thread; the position of the outer wall of the cylinder corresponding to the cap is provided with a thread matching the internal thread, and the cap corresponds to The position of the end of the cylinder body is provided with a plurality of notch grooves along the axial direction of the cylinder body, the length of the notch groove is greater than the length from the flange to the end of the cylinder body with the sleeve cap, and the notch groove evenly divides the end of the cylinder body into a plurality of belts. Flanged bayonet tab.

Further, the middle part of the connecting pipe is connected with a conduit joint through a three-way valve, and a pointer for indicating the communication direction is provided on the control knob of the three-way valve.

Further, the outer wall of the nipple of the syringe and the inner wall of the needle plug are connected by threads.

Further, both the cap and the cylinder are made of transparent materials.

Further, the side wall of the injection needle tube is provided with a through hole passing through the wall of the injection needle tube, the through hole is located on the injection needle tube near the needle tip, and the distance between the through hole and the needle tip is greater than or equal to the thickness of the vial cap.

Further, the inner cavity of the injection needle tube is provided with a one-way air valve for the medium to flow from the inner cavity of the injection needle tube to the direction of the needle tip, and the one-way air valve is located between the through hole and the needle tip.

Further, the one-way air valve is a duckbill valve, the duckbill valve includes an inner tube that can be fixed in the inner cavity of the injection needle tube, the inner tube is made of elastic material, the diameter of the inner tube is equal to the inner diameter of the injection needle tube, and the inner tube is close to the needle tip. The edge of the port is a V-shaped structure with contact closure, and the tip of the V-shaped structure faces the direction of the needle tip of the injection needle.

In order to solve the above-mentioned technical problems, the present invention also provides a method for using a closed-type compounding device for antitumor drugs, comprising the following steps:

S1. Insert the end of the vial with the cap into the cylinder from the open end of the cylinder without the cap, push the vial to make the flange in the cylinder clamp the neck of the vial, and make the inner side of the cap clamp the vial. The tip of the injection needle is gradually inserted into the inner cavity of the vial, and the through hole is kept outside the vial to balance the air pressure in the vial;

S2. Gradually insert the injection needle into the vial until the through hole is located in the inner cavity of the vial and close to the inner wall of the cap, insert the syringe nipple from which the solvent liquid has been extracted into the needle plug, and push the plunger rod of the syringe to make the inside of the syringe The solvent liquid enters the vial through the lumen of the connecting tube and the injection needle in turn;

S3. Hold the syringe, the cap and the cylinder and shake the medicine in the vial to make the medicine in the vial in the cylinder fully mixed and dissolved, then invert the cylinder so that the cap of the vial faces down, and pull the side of the syringe. Push the piston rod to draw the mixed drug in the vial into the syringe.

Further, the middle part of the connecting pipe is connected with a catheter joint through a three-way valve. After the mixed medicine in the vial is pumped to the syringe, the three-way valve is adjusted to make the syringe-connecting pipe-catheter joint in a passage state, and then push the piston of the syringe. The push rod transfers the prepared drug in the syringe to the infusion bag, infusion bottle or other drug transfer and delivery equipment through the catheter connector, so that the drug is in a sealed environment during the entire configuration process of the chemotherapeutic drug.

Compared with the prior art, the beneficial effects of the present invention are:

1. The present invention inserts the vial into the cylinder and inserts the injection needle inside the cap into the vial, utilizes the flange in the cylinder to clamp the neck of the vial, injects the solvent liquid into the vial through the injection needle, and then Shake the medicine in the vial by holding the cylinder. During the process, it can prevent the liquid in the vial from splashing into the air, prevent the medicine from damaging the mucous membranes or skin of the medical staff, and avoid the occurrence of needle stick injuries.

2. Use the cap to tighten the bayonet piece of the cylinder to fix the vial and further prevent the vial from being thrown out of the cylinder when the medicine is shaken.

3. Add a three-way valve and a conduit joint on the connecting pipe, and control the three-way valve to realize the on-off of the solvent liquid injection, drug suction and drug transfer process. The drug is in a closed environment during the whole process, and it also reduces Unnecessary plugging and unplugging of lines further prevents drug splashing or dripping.

4. A through hole is set on the upper tube wall of the injection needle. First, the air pressure in the vial can be balanced through the through hole during the piercing of the injection needle, avoiding the negative pressure in the vial during the subsequent drug suction process. The problem is that the resistance is relatively large; the second is that in the process of drug suctioning by inverting the vial, the through hole is located close to the inner wall of the vial cap, so that the drug can be completely sucked and the dosage of the drug is ensured.

5. A one-way air valve is set between the needle tip and the through hole of the injection needle to ensure that when the liquid level of the drug in the vial is lower than the needle tip, the air in the vial will not be drawn out with the drug, avoiding the need for medical staff to repeat Exhaust gas, and the problem of generating aerosol pollution.

Description of drawings

Fig. 1 is the three-dimensional structure schematic diagram of the dispensing device for chemotherapeutic drugs in embodiment 1 and 2;

2 is a schematic diagram of the position of the injection needle tube relative to the vial when the through hole on the injection needle tube is used to balance the air pressure in Embodiments 1 and 2;

Fig. 3 is a schematic diagram of the position of the injection needle relative to the vial when the vial is inverted in Embodiments 1 and 2 and utilizes the through-hole to suck the medicine;

4 is a schematic diagram of the positional relationship between the through hole and the one-way air valve on the injection needle in Embodiments 1 and 2;

Fig. 5 is the structural representation of the duckbill valve when the air flow enters the vial from the V-shaped structure tip contacting the closed part in Examples 1 and 2;

Among them: 1. Vial; 2. Cylinder; 3. Cap; 4. Flange; 5. Connecting tube; 6. Injection needle; 7. Needle plug; , Three-way valve; 11, conduit joint; 12, through hole; 13, duckbill valve; 14, syringe.

Detailed ways

In order to make the purpose, technical solutions and advantages of the present invention clearer, the present invention will be further described in detail below with reference to the embodiments and the accompanying drawings. as a limitation of the present invention.

Example 1:

Referring to Figures 1-3, a closed-type compounding device for antineoplastic drugs includes a cylinder 2 with open ends at both ends and an inner diameter greater than the outer diameter of the vial 1. One end of the cylinder 2 is provided with The cap 3 for capping the end, the inner wall of the cylinder 2 is provided with a flange 4 that can clamp the neck of the vial 1, the flange 4 is located near the end of the cylinder 2 with the cap 3, the flange 4 is made of an elastic material; one end of the cap 3 is open, the other end is provided with a top cover, and a connecting tube 5 is fixed in the middle of the top of the cap 3; the end of the connecting tube 5 near the cap 3 is coaxially provided with an injection needle 6 , the central axis of the injection needle 6 and the central axis of the barrel 2 are on the same line, the needle tip of the injection needle 6 passes through the top cover of the cap 3 and extends to the middle of the barrel 2; The head is provided with a needle plug 7 that can be sleeved with the nipple of the syringe 14 , and both the injection needle tube 6 and the needle plug 7 communicate with the inner cavity of the connecting tube 5 .

In this embodiment, when the vial 1 needs to be used to prepare the medicine, the syringe 14 is used to extract the solvent liquid required for the preparation of the medicine in advance, and then the cap of the vial 1 and the cap 3 of the cylinder 2 are adjusted to face the same direction, One end of the capped vial 1 is inserted into the cylinder 2 from the open end of the cylinder 2 without the cap 3, and the vial 1 is pushed hard to make the inner flange 4 of the cylinder 2 clamp the neck of the vial 1. During the process of pushing the vial 1 , the injection needle 6 inside the cap 3 is gradually inserted into the inner cavity of the vial 1 . Then insert the nipple of the syringe 14 that has extracted the solvent liquid into the needle plug 7, and push the piston push rod of the syringe 14 to make the solvent liquid in the syringe 14 enter the vial 1 through the lumen of the connecting tube 5 and the injection needle tube 6 in turn; then Hold the syringe 14, the cap 3 and the cylinder body 2 and shake them well, so that the medicine in the vial 1 in the cylinder body 2 is fully mixed and dissolved, then pull the piston push rod of the syringe 14, and the mixed medicine in the vial 1 is pumped to In the syringe 14, the mixing configuration of the drugs in the vial 1 is realized. During the drug preparation and shaking process, the drug liquid may leak from the gap between the injection needle 6 and the cap of the vial 1 due to the injection or shaking of the solvent liquid. The process (especially when shaking) is in the barrel 2, and is covered with a cap 3, so that the leaked drug liquid will not splash on the skin of the medical staff or be dispersed in the air, especially chemotherapy drugs or some drugs that are harmful to the skin. Drugs that have a damaging effect can play a very good protective role. At the same time, the flange 4 in the cylinder body 2 is stuck to the neck of the vial 1, so that the vial 1 is not easily separated from the cylinder body 2 and thrown out, so as to ensure the smooth progress of the drug preparation process.

The position of the inner wall of the sleeve cap 3 close to the top cover is provided with a constricted section 8, and the position of the inner wall of the sleeve cap 3 close to the opening is provided with an internal thread; The position of the end of the cylinder body 2 corresponding to the cap 3 is provided with a plurality of notched grooves along the axial direction of the cylinder body 2. The length of the notched grooves is greater than the length from the flange 4 to the end of the cylinder body 2 with the cap 3, and the notched grooves separate the cylinder body. 2 The ends are evenly divided into a plurality of bayonet pieces 9 with flanges 4 . In this embodiment, the cap 3 and the cylinder body 2 are connected by threads. During the process of shaking the medicine, the cap 3 and the cylinder body 2 can be prevented from being separated from each other and the cylinder body 2 being thrown out. During the screwing process of the sleeve cap 3 and the cylinder body 2, after the end of the cylinder body 2 with the notch groove is in contact with the constricted section 8 in the sleeve cap 3, the constricted section 8 will gradually align with each bayonet piece 9. A thrust is generated, so that each bayonet piece 9 is gradually moved closer to the central axis of the cylinder body 2. At this time, the flange 4 or the inner wall of the bayonet piece 9 will grip the neck of the vial 1 or the side wall of the vial body of the vial 1. force, the vial 1 is firmly stuck in the cylinder body 2, and the vial 1 is further prevented from being thrown out during the process of shaking the medicine. In addition, the outer wall of the nipple of the syringe 14 and the inner wall of the needle plug 7 are connected by threads, which can ensure that the needle plug 7 will not be separated from the syringe 14 due to pressure changes during the shaking process.

The middle of the connecting pipe 5 is connected with a conduit joint 11 through a three-way valve 10. The conduit joint 11 in this embodiment is used to transfer the medicine that has been configured in the syringe 14 to an infusion bag, an infusion bottle or other medicine transfer equipment, or An injection needle is set at the front end of the catheter connector 11 as required to directly inject the patient, and the medicine is in a sealed environment during the entire operation, which reduces the insertion and extraction of the syringe 14 or the delivery pipeline in the middle process, and further prevents the medicine from dripping or splashing during the medicine transfer process.

The operation sequence of the three-way valve 10 is as follows: after the vial 1 is pushed into the cylinder 2 and the injection needle 6 is inserted into the vial 1, the control knob of the three-way valve 10 is adjusted so that the needle plug 7 (syringe 14)—the connecting pipe 5— The injection needle 6 is in the passageway, the catheter joint 11 and the connecting pipe 5 are in an open circuit state, and then the solvent liquid in the syringe 14 is injected into the vial 1, and shaken to dissolve the medicine in the vial 1 completely; keep the needle plug 7 -connecting tube 5-injection needle tube 6 access, the catheter joint 11 and the connecting tube 5 are in an open circuit state, use the syringe 14 to extract the medicine in the vial 1 into the syringe 14; then adjust the control knob of the three-way valve 10 to make the needle plug 7 (syringe 14)—connecting pipe 5—catheter joint 11 is in the passage, the injection needle 6 and the connecting pipe 5 are in an open circuit state, and then the medicine in the syringe 14 is pushed out to the conduit joint 11, and is introduced into the corresponding equipment by the conduit joint 11 or injected directly into the patient. In this embodiment, the control knob of the three-way valve 10 is provided with a pointer for indicating the direction of communication, which enables medical personnel to intuitively and quickly determine the on-off path of the three-way valve 10 and facilitates the medical personnel to operate.

1-4, the side wall of the injection needle tube 6 is provided with a through hole 12 that penetrates the wall of the injection needle tube 6, the through hole 12 is located on the injection needle tube 6 near the needle tip, and the distance between the through hole 12 and the needle tip is greater than or equal to cillin Thickness of bottle 1 cap. Because in most cases, especially when the medicament in the vial 1 is powder, the vial 1 is in a negative pressure state. If the injection needle 6 injects a small amount of solvent liquid, the vial 1 is still in a negative pressure state. During the process of using the syringe 14 to extract the medicine, it is difficult for the medical staff to extract the medicine in the vial 1, which is time-consuming and labor-intensive. In this embodiment, when the needle tip of the injection needle 6 pierces the cap of the vial 1 and gradually extends into the inner cavity of the vial 1, and the through hole 12 is still outside the cap of the vial 1, the needle tip of the injection needle 6 and the tube wall The through hole 12 connects the air pressure in the vial 1 with the air pressure outside the vial 1, so that the air pressure in the vial 1 is balanced with the air pressure outside the vial 1; then continue to pierce the injection needle 6 so that the through hole 12 is located in the vial 12 The solvent liquid is pushed into the bottle 1, and the medicine is prepared. In the subsequent drug extraction process, the suction resistance when the drug is extracted is small, and the problem of difficulty in drug aspiration will not occur.

In addition, when the injection needle in the prior art is used to extract the medicine from the vial 1, in order to ensure that the medicine in the vial 1 is completely drawn out, the syringe 14 is generally turned upward, the vial 1 is turned upside down, and then the injection needle is placed The needle tip is gradually pulled outwards, so that the needle tip is close to the inner position of the vial cap of vial 1, and then the drug in vial 1 is sucked; The liquid level in the bottle 1 is lower than the needle tip, and the injection needle needs to be pulled out while suctioning. This process is relatively cumbersome, and the injection needle will be pulled out directly if you are not careful, and there is a risk of stabbing the medical staff; and the medicine in the vial 1 has not been completely drawn out, and the injection needle needs to be pierced into the vial 1 repeatedly. . In this embodiment, a through hole 12 is provided on the wall of the injection needle tube 6, and the cap 3 and the cylinder body 2 are made of transparent materials. , the medical staff observes and adjusts the position of the through hole 12 so that the through hole 12 is just located in the vial 1 near the cap of the vial 1, and then injects the solvent liquid. When it is necessary to extract the medicine in the vial 1, first place the cap 3 on the cylinder body 2 downwards, at this time the cap of the vial 1 is facing down, and the medicine in the vial 1 can be directly extracted. The medicine in the bottle 1 can be completely extracted through the through hole 12 , even if the position of the through hole 12 needs to be adjusted during the piercing process, the problem of pulling out the entire injection needle 6 is not easy to occur.

The inner cavity of the injection needle tube 6 is provided with a one-way air valve for the medium to flow from the inner cavity of the injection needle tube 6 to the needle tip, and the one-way air valve is located between the through hole 12 and the needle tip. When the medicine in the vial 1 is extracted through the through hole 12, when the liquid level of the medicine in the vial 1 is lower than the position of the needle tip, the gas in the vial 1 will be easily extracted through the needle tip, so that the medicine is mixed with Gas, the subsequent operation process needs to repeatedly adjust the syringe 14 to remove the gas; the setting of the one-way gas valve can ensure that the injection needle 6 pierces the vial 1 process, the gas entering from the through hole 12 enters the needle tip through the one-way gas valve and then It is discharged into the vial 1 to balance the air pressure in the vial 1 and reduce the suction resistance when the subsequent drug is drawn out; and when the liquid level of the drug is lower than the needle tip during the suction process, the gas in the vial 1 does not flow. It will enter the injection needle tube 6 through the needle tip part, and it is not necessary for the medical staff to adjust the syringe 14 repeatedly to remove the gas, which saves time and effort.

1-5, the one-way air valve in this embodiment is a duckbill valve 13. The duckbill valve 13 includes an inner tube that can be fixed to the inner cavity of the injection needle 6. The inner tube is made of elastic material, and the diameter of the inner tube is Equal to the inner diameter of the injection needle tube 6 , the port edge of the inner tube close to the needle tip is in a V-shaped structure with contact and closure, and the tip of the V-shaped structure faces the direction of the needle tip of the injection needle tube 6 . When the injection needle 6 pierces the vial 1 and the through hole 12 is located outside the vial 1, the external gas enters the injection needle 6 through the through hole 12, and then enters the inner pipe of the duckbill valve 13, and the tip of the V-shaped structure contacts the When the closed part is opened, the gas enters the needle tip side from the tip of the V-shaped structure, and finally enters the vial 1 to realize the air pressure balance between the inside and outside of the bottle. During the upside-down drug suction process of the vial 1, the external gas or liquid produces a downward thrust on the tip of the V-shaped structure, and the contact and closed parts of the V-shaped structure are in closer contact, so that the liquid or gas cannot pass through the injection needle 6. The needle tip enters the injection needle tube 6 , especially to ensure that when the liquid level in the vial 1 is lower than the needle tip, the gas in the vial 1 will not be drawn into the syringe 14 .

It should be noted that, in this embodiment, the cap 3, the injection needle 6, the three-way valve 10, the needle plug 7, the catheter joint 11 and other substances that come into contact with the drug or solvent liquid are all for one-time use, which can prevent cross-contamination; The cylinder body 2 with the flange 4 and the bayonet piece 9 can realize no contact with the medicine during the whole operation process, so the cylinder body 2 can be reused without being contaminated by the medicine, saving resources, reducing consumption and saving costs .

In addition, the material of the cap 3 and the barrel 2 can be glass or other transparent, moldable and non-polluting materials, and the injection needle 6 can be made of plastic or metal. In this embodiment, the cap 3 and the cylinder body 2 are both made of transparent polycarbonate, and the material of the injection needle tube 6 is plastic, which is low in cost and easy to process.

Example 2

Referring to Figures 1-5, a method for using a closed-type compounding device for antineoplastic drugs, comprising the following steps:

S1. Insert the end of the vial 1 with the cap into the cylinder 2 from the open end of the cylinder 2 without the cap 3, and push the vial 1 to make the inner flange 4 of the cylinder 2 jam the vial 1 and insert the tip of the injection needle 6 inside the cap 3 into the inner cavity of the vial 1 gradually, and keep the through hole 12 outside the vial 1 to balance the air pressure in the vial 1;

S2, gradually pierce the injection needle 6 into the vial 1 until the through hole 12 is located in the inner cavity of the vial 1 and close to the inner wall of the bottle cap, insert the nipple of the syringe 14 for extracting the solvent liquid into the needle plug 7, and push the syringe 14 The plunger push rod makes the solvent liquid in the syringe 14 enter the vial 1 through the connecting tube lumen and the injection needle tube 6 in turn;

S3, hold the syringe 14, the cap 3 and the cylinder 2 and shake the medicine in the vial 1 to make the medicine in the vial 1 in the cylinder 2 fully mixed and dissolved, and then invert the cylinder 2 to make the vial 1 With the bottle cap facing down, pull the piston push rod of the syringe 14 to pump the mixed medicine in the vial 1 into the syringe 14 . On the basis of preventing the drug from splashing during the mixing process, the through hole 12 is provided on the injection needle 6 to achieve the balance of the air pressure in the vial 1, avoiding the problem of large air pressure resistance during the injection of the solvent.

The middle part of the connecting pipe is connected with the catheter joint 11 through the three-way valve 10. After the mixed medicine in the vial 1 is pumped to the syringe 14, the three-way valve 10 is adjusted to make the syringe 14-connecting pipe-catheter joint 11 in the channel state, and then pass through Push the plunger rod of the syringe 14 to transfer the configured drug in the syringe 14 to the infusion bag, infusion bottle or other drug transfer and delivery equipment through the catheter connector 11, so that the drug is in a sealed environment during the entire configuration process of the chemotherapeutic drug.

Other parts in this embodiment are the same as those in Embodiment 1, and are not repeated here.

The above is an embodiment of the present invention. The above examples and the specific parameters in the examples are only to clearly describe the invention verification process, not to limit the scope of patent protection of the present invention. The scope of patent protection of the present invention is still based on the claims. Equivalent structural changes made in the contents of the description and drawings shall be included within the protection scope of the present invention.

Claims (10)

1. A closed dispensing device for antineoplastic drugs, characterized in that: the penicillin bottle opening device comprises a barrel body (2) with two open ends and an inner diameter larger than the outer diameter of a penicillin bottle (1), wherein a sleeve cap (3) capable of sealing the end of the barrel body (2) in a covering mode is arranged at one end of the barrel body (2), a flange (4) capable of clamping the neck of the penicillin bottle (1) is arranged on the inner wall of the barrel body (2), the flange (4) is located close to the end of the barrel body (2) with the sleeve cap (3), and the flange (4) is made of elastic materials; one end of the sleeve cap (3) is open, the other end of the sleeve cap is provided with a top cover, and a connecting pipe (5) is fixed in the middle of the top of the sleeve cap (3); an injection needle tube (6) is coaxially arranged at the end of the connecting tube (5) close to the sleeve cap (3), the central axis of the injection needle tube (6) and the central axis of the barrel (2) are positioned on the same straight line, and the needle tip of the injection needle tube (6) penetrates through the top cover of the sleeve cap (3) and extends to the middle position of the barrel (2); keep away from connecting pipe (5) end of cover cap (3) is provided with pintle (7) that can cup joint with syringe (14) nipple, injection needle tubing (6) with pintle (7) all with the inner chamber intercommunication of connecting pipe (5).

2. The hermetic dispensing device for antitumor drugs as in claim 1, characterized in that: a necking section (8) is arranged at the position, close to the top cover, of the inner wall of the sleeve cap (3), and an internal thread is arranged at the position, close to the opening, of the inner wall of the sleeve cap (3); barrel (2) outer wall position that cover cap (3) correspond is provided with the screw thread with internal thread assorted, barrel (2) end position that cover cap (3) correspond is provided with a plurality of breach grooves along barrel (2) axial, the length in breach groove is greater than flange (4) to the barrel (2) end length that has cover cap (3), the breach groove will barrel (2) end evenly cut apart into a plurality of bayonet socket pieces (9) that have flange (4).

3. The hermetic dispensing device for antitumor drugs as in claim 1, characterized in that: the middle part of the connecting pipe (5) is connected with a conduit joint (11) through a three-way valve (10), and a control knob of the three-way valve (10) is provided with a pointer for indicating the communication direction.

4. The hermetic dispensing device for antitumor drugs as in claim 1, characterized in that: the outer wall of the nipple of the injector (14) is connected with the inner wall of the pintle (7) through screw threads.

5. The hermetic dispensing device for antitumor drugs according to any one of claims 1 to 4, characterized in that: the side wall of the injection needle tube (6) is provided with a through hole (12) penetrating through the tube wall of the injection needle tube (6), the through hole (12) is located on the injection needle tube (6) and close to the needle point, and the distance between the through hole (12) and the needle point is larger than or equal to the thickness of a bottle cap of the penicillin bottle (1).

6. A closed dispensing device for antineoplastic drugs according to claim 5, characterized in that: the sleeve cap (3) and the barrel body (2) are both made of transparent materials.

7. A closed dispensing device for antineoplastic drugs according to claim 6, characterized in that: and a one-way air valve which can allow a medium to flow from the inner cavity of the injection needle tube (6) to the needle point direction is arranged in the inner cavity of the injection needle tube (6), and the one-way air valve is positioned between the through hole (12) and the needle point.

8. A closed dispensing device for antineoplastic drugs according to claim 7, characterized in that: one-way air valve is duckbilled valve (13), duckbilled valve (13) are including being fixed in the inner tube of injection needle pipe (6) inner chamber, the inner tube is made by elastic material, the diameter of inner tube equals the internal diameter of injection needle pipe (6), the port edge that the inner tube is close to the needle point is the closed V type structure of contact, the point portion of V type structure is towards the needle point direction of injection needle pipe (6).

9. A method for using a closed dispensing device for antitumor drugs, based on the closed dispensing device for antitumor drugs of claim 8, comprising the steps of:

s1, inserting the end of a penicillin bottle (1) with a bottle cap into a cylinder body (2) from the open end of the cylinder body (2) without a sleeve cap (3), pushing the penicillin bottle (1) to enable an inner flange (4) of the cylinder body (2) to clamp the neck of the penicillin bottle (1), gradually inserting the sharp part of an injection needle tube (6) on the inner side of the sleeve cap (3) into the inner cavity of the penicillin bottle (1), keeping a through hole (12) outside the penicillin bottle (1), and balancing the air pressure in the penicillin bottle (1);

s2, gradually puncturing the injection needle tube (6) into the penicillin bottle (1) until the through hole (12) is positioned in the inner cavity of the penicillin bottle (1) and close to the inner wall of the bottle cap, inserting the nipple of the injector (14) with the solvent liquid extracted into the pintle (7), and pushing the piston push rod of the injector (14) to enable the solvent liquid in the injector (14) to sequentially enter the penicillin bottle (1) through the inner cavity of the connecting tube (5) and the injection needle tube (6);

s3, holding the syringe (14), sleeving the cap (3) and the barrel (2), shaking up the medicines in the penicillin bottle (1), fully mixing and dissolving the medicines in the penicillin bottle (1) in the barrel, then inverting the barrel (2) to enable the bottle cap of the penicillin bottle (1) to face downwards, pulling the piston push rod of the syringe (14), and pumping the mixed medicines in the penicillin bottle (1) into the syringe (14).

10. The use of a closed dispensing device for antineoplastic drugs according to claim 9, characterized in that: the middle part of the connecting pipe (15) is connected with a conduit joint (11) through a three-way valve (10), after the mixed medicine in the penicillin bottle (1) is pumped to the injector (14), the three-way valve (10) is adjusted to enable the injector (14), the connecting pipe (5) and the conduit joint (11) to be in a passage state, and then the prepared medicine in the injector (14) is transferred to an infusion bag, an infusion bottle or other medicine transfer conveying equipment through the conduit joint (11) by pushing a piston push rod of the injector (14), so that the medicine is in a sealed environment in the whole preparation process of the chemotherapy medicine.

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