CN111465421B - 用于收集血浆的系统和方法 - Google Patents
用于收集血浆的系统和方法 Download PDFInfo
- Publication number
- CN111465421B CN111465421B CN201880079926.0A CN201880079926A CN111465421B CN 111465421 B CN111465421 B CN 111465421B CN 201880079926 A CN201880079926 A CN 201880079926A CN 111465421 B CN111465421 B CN 111465421B
- Authority
- CN
- China
- Prior art keywords
- plasma
- volume
- donor
- anticoagulant
- blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 238000000034 method Methods 0.000 title claims abstract description 102
- 239000003146 anticoagulant agent Substances 0.000 claims abstract description 234
- 229940127219 anticoagulant drug Drugs 0.000 claims abstract description 234
- 210000004369 blood Anatomy 0.000 claims abstract description 194
- 239000008280 blood Substances 0.000 claims abstract description 194
- 239000012503 blood component Substances 0.000 claims abstract description 112
- 238000000926 separation method Methods 0.000 claims abstract description 96
- 239000000306 component Substances 0.000 claims abstract description 89
- 238000005534 hematocrit Methods 0.000 claims abstract description 66
- 238000012545 processing Methods 0.000 claims abstract description 42
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 39
- 210000003743 erythrocyte Anatomy 0.000 claims description 38
- 239000011780 sodium chloride Substances 0.000 claims description 38
- 239000012530 fluid Substances 0.000 claims description 22
- 230000003287 optical effect Effects 0.000 claims description 19
- 230000008859 change Effects 0.000 claims description 17
- 230000007812 deficiency Effects 0.000 claims description 10
- 239000000470 constituent Substances 0.000 claims description 9
- 238000012544 monitoring process Methods 0.000 claims description 4
- 210000002381 plasma Anatomy 0.000 description 295
- 210000001772 blood platelet Anatomy 0.000 description 11
- 210000000265 leukocyte Anatomy 0.000 description 9
- 230000008569 process Effects 0.000 description 9
- 238000005303 weighing Methods 0.000 description 6
- 238000002617 apheresis Methods 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 230000037396 body weight Effects 0.000 description 3
- 239000012267 brine Substances 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 3
- 206010042772 syncope Diseases 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000003204 osmotic effect Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 206010036653 Presyncope Diseases 0.000 description 1
- 241000134128 Syncope Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- -1 red blood cells Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000000392 somatic effect Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/38—Removing constituents from donor blood and storing or returning remainder to body, e.g. for transfusion
- A61M1/382—Optimisation of blood component yield
- A61M1/385—Optimisation of blood component yield taking into account of the patient characteristics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3496—Plasmapheresis; Leucopheresis; Lymphopheresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3607—Regulation parameters
- A61M1/3609—Physical characteristics of the blood, e.g. haematocrit, urea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3672—Means preventing coagulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0415—Plasma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3306—Optical measuring means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3379—Masses, volumes, levels of fluids in reservoirs, flow rates
- A61M2205/3393—Masses, volumes, levels of fluids in reservoirs, flow rates by weighing the reservoir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/20—Blood composition characteristics
- A61M2230/207—Blood composition characteristics hematocrit
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- External Artificial Organs (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410195480.5A CN117959513A (zh) | 2017-10-25 | 2018-10-25 | 用于收集血浆的系统和方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15/793,339 US10792416B2 (en) | 2017-05-30 | 2017-10-25 | System and method for collecting plasma |
| US15/793,339 | 2017-10-25 | ||
| PCT/US2018/057528 WO2019084278A1 (en) | 2017-10-25 | 2018-10-25 | PLASMA COLLECTION SYSTEM AND METHOD |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202410195480.5A Division CN117959513A (zh) | 2017-10-25 | 2018-10-25 | 用于收集血浆的系统和方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111465421A CN111465421A (zh) | 2020-07-28 |
| CN111465421B true CN111465421B (zh) | 2024-03-08 |
Family
ID=66247057
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202410195480.5A Pending CN117959513A (zh) | 2017-10-25 | 2018-10-25 | 用于收集血浆的系统和方法 |
| CN201880079926.0A Active CN111465421B (zh) | 2017-10-25 | 2018-10-25 | 用于收集血浆的系统和方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202410195480.5A Pending CN117959513A (zh) | 2017-10-25 | 2018-10-25 | 用于收集血浆的系统和方法 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP3700606A4 (de) |
| JP (3) | JP7390287B2 (de) |
| KR (2) | KR102629919B1 (de) |
| CN (2) | CN117959513A (de) |
| AU (2) | AU2018355417B2 (de) |
| CA (1) | CA3079851A1 (de) |
| SA (1) | SA520411828B1 (de) |
| WO (1) | WO2019084278A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11386993B2 (en) | 2011-05-18 | 2022-07-12 | Fenwal, Inc. | Plasma collection with remote programming |
| US10758652B2 (en) | 2017-05-30 | 2020-09-01 | Haemonetics Corporation | System and method for collecting plasma |
| US10792416B2 (en) | 2017-05-30 | 2020-10-06 | Haemonetics Corporation | System and method for collecting plasma |
| EP3621674B1 (de) | 2018-05-21 | 2021-09-15 | Fenwal, Inc. | Systeme zur optimierung von plasmagewinnungsvolumina |
| US11412967B2 (en) | 2018-05-21 | 2022-08-16 | Fenwal, Inc. | Systems and methods for plasma collection |
| US12033750B2 (en) | 2018-05-21 | 2024-07-09 | Fenwal, Inc. | Plasma collection |
| CN111999488A (zh) * | 2019-05-11 | 2020-11-27 | 南京岚煜生物科技有限公司 | 一种便于全血检测的定量的方法 |
| CN111529791B (zh) * | 2020-05-08 | 2022-11-29 | 四川天府亨特生命科技有限公司 | 可减少采集血浆中白细胞混入量的方法及血浆采集系统 |
| WO2022086623A1 (en) * | 2020-10-23 | 2022-04-28 | Fenwal, Inc. | Plasma collection with remote programming |
| WO2022159132A1 (en) * | 2021-01-22 | 2022-07-28 | Fenwal, Inc. | Systems and methods for plasma collection |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5681273A (en) * | 1991-12-23 | 1997-10-28 | Baxter International Inc. | Systems and methods for predicting blood processing parameters |
| US6200287B1 (en) * | 1997-09-05 | 2001-03-13 | Gambro, Inc. | Extracorporeal blood processing methods and apparatus |
| JP2002282352A (ja) * | 2001-03-26 | 2002-10-02 | Terumo Corp | 血液成分採取装置 |
| WO2012091720A1 (en) * | 2010-12-30 | 2012-07-05 | Haemonetics Corporation | System and method for collecting platelets and anticipating plasma return |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6319471B1 (en) * | 1992-07-10 | 2001-11-20 | Gambro, Inc. | Apparatus for producing blood component products |
| US6348156B1 (en) * | 1999-09-03 | 2002-02-19 | Baxter International Inc. | Blood processing systems and methods with sensors to detect contamination due to presence of cellular components or dilution due to presence of plasma |
| BR0014802A (pt) | 1999-10-16 | 2003-11-11 | Baxter Int | Sistemas e métodos automatizados para a coleta para obter células sanguìneas vermelhas, plaquetas e plasma do sangue total |
| US6730054B2 (en) * | 1999-10-16 | 2004-05-04 | Baxter International Inc. | Blood collection systems and methods that derive estimated effects upon the donor's blood volume and hematocrit |
| US20030125881A1 (en) * | 2001-11-26 | 2003-07-03 | Ryan Vincent J. | Apparatus and method for plasmapheresis |
| US20060226086A1 (en) * | 2005-04-08 | 2006-10-12 | Robinson Thomas C | Centrifuge for blood processing systems |
| US8834402B2 (en) * | 2009-03-12 | 2014-09-16 | Haemonetics Corporation | System and method for the re-anticoagulation of platelet rich plasma |
| US8852140B2 (en) * | 2011-01-12 | 2014-10-07 | Fenwal, Inc. | System and method for adjustment of blood separation procedure parameters |
| ES2622652T3 (es) * | 2011-05-27 | 2017-07-06 | Grifols, S.A. | Alineación de anticoagulante de cebado para extracción de sangre |
-
2018
- 2018-10-25 AU AU2018355417A patent/AU2018355417B2/en active Active
- 2018-10-25 CN CN202410195480.5A patent/CN117959513A/zh active Pending
- 2018-10-25 KR KR1020207014404A patent/KR102629919B1/ko active Active
- 2018-10-25 JP JP2020522968A patent/JP7390287B2/ja active Active
- 2018-10-25 KR KR1020247002589A patent/KR20240017096A/ko active Pending
- 2018-10-25 EP EP18870564.4A patent/EP3700606A4/de active Pending
- 2018-10-25 CA CA3079851A patent/CA3079851A1/en active Pending
- 2018-10-25 CN CN201880079926.0A patent/CN111465421B/zh active Active
- 2018-10-25 WO PCT/US2018/057528 patent/WO2019084278A1/en active Application Filing
-
2020
- 2020-04-23 SA SA520411828A patent/SA520411828B1/ar unknown
-
2023
- 2023-08-17 JP JP2023132897A patent/JP2023154074A/ja active Pending
-
2024
- 2024-12-27 JP JP2024231619A patent/JP2025038241A/ja active Pending
-
2025
- 2025-01-31 AU AU2025200662A patent/AU2025200662A1/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5681273A (en) * | 1991-12-23 | 1997-10-28 | Baxter International Inc. | Systems and methods for predicting blood processing parameters |
| US6200287B1 (en) * | 1997-09-05 | 2001-03-13 | Gambro, Inc. | Extracorporeal blood processing methods and apparatus |
| JP2002282352A (ja) * | 2001-03-26 | 2002-10-02 | Terumo Corp | 血液成分採取装置 |
| WO2012091720A1 (en) * | 2010-12-30 | 2012-07-05 | Haemonetics Corporation | System and method for collecting platelets and anticipating plasma return |
Also Published As
| Publication number | Publication date |
|---|---|
| CN111465421A (zh) | 2020-07-28 |
| AU2018355417A1 (en) | 2020-05-14 |
| KR102629919B1 (ko) | 2024-01-30 |
| KR20240017096A (ko) | 2024-02-06 |
| JP2021500950A (ja) | 2021-01-14 |
| RU2020116822A3 (de) | 2021-11-25 |
| RU2020116822A (ru) | 2021-11-25 |
| SA520411828B1 (ar) | 2024-03-05 |
| AU2018355417B2 (en) | 2024-10-31 |
| CA3079851A1 (en) | 2019-05-02 |
| JP7390287B2 (ja) | 2023-12-01 |
| WO2019084278A1 (en) | 2019-05-02 |
| JP2023154074A (ja) | 2023-10-18 |
| KR20200078553A (ko) | 2020-07-01 |
| CN117959513A (zh) | 2024-05-03 |
| EP3700606A1 (de) | 2020-09-02 |
| AU2025200662A1 (en) | 2025-02-20 |
| EP3700606A4 (de) | 2021-08-04 |
| JP2025038241A (ja) | 2025-03-18 |
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