CN111449975A - Microemulsion and preparation method thereof - Google Patents
Microemulsion and preparation method thereof Download PDFInfo
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- CN111449975A CN111449975A CN201910059531.0A CN201910059531A CN111449975A CN 111449975 A CN111449975 A CN 111449975A CN 201910059531 A CN201910059531 A CN 201910059531A CN 111449975 A CN111449975 A CN 111449975A
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- microemulsion
- parts
- emulsifier
- oil
- extract
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- 239000004530 micro-emulsion Substances 0.000 title claims abstract description 51
- 238000002360 preparation method Methods 0.000 title claims abstract description 7
- 238000000593 microemulsion method Methods 0.000 title description 2
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 17
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 claims abstract description 16
- 239000003960 organic solvent Substances 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229960000271 arbutin Drugs 0.000 claims abstract description 8
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000000284 extract Substances 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 239000003921 oil Substances 0.000 claims description 6
- 235000019198 oils Nutrition 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- 239000003755 preservative agent Substances 0.000 claims description 5
- 230000002335 preservative effect Effects 0.000 claims description 5
- 239000002562 thickening agent Substances 0.000 claims description 5
- 239000000419 plant extract Substances 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- AMUTYVGRCVFCCD-UHFFFAOYSA-N 5,6-diaminopyridine-3-carboxylic acid Chemical compound NC1=CC(C(O)=O)=CN=C1N AMUTYVGRCVFCCD-UHFFFAOYSA-N 0.000 claims description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 3
- 244000144725 Amygdalus communis Species 0.000 claims description 3
- 235000011437 Amygdalus communis Nutrition 0.000 claims description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 3
- 241001072282 Limnanthes Species 0.000 claims description 3
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 3
- 229920002125 Sokalan® Polymers 0.000 claims description 3
- 239000008168 almond oil Substances 0.000 claims description 3
- 239000012874 anionic emulsifier Substances 0.000 claims description 3
- 229960001631 carbomer Drugs 0.000 claims description 3
- 239000004359 castor oil Substances 0.000 claims description 3
- 235000019438 castor oil Nutrition 0.000 claims description 3
- 239000001913 cellulose Substances 0.000 claims description 3
- 229920002678 cellulose Polymers 0.000 claims description 3
- 125000004494 ethyl ester group Chemical group 0.000 claims description 3
- 239000008103 glucose Substances 0.000 claims description 3
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 3
- 239000008169 grapeseed oil Substances 0.000 claims description 3
- -1 jojoba oil Chemical compound 0.000 claims description 3
- 229940119170 jojoba wax Drugs 0.000 claims description 3
- 229940083980 lavender extract Drugs 0.000 claims description 3
- 235000020723 lavender extract Nutrition 0.000 claims description 3
- 235000010446 mineral oil Nutrition 0.000 claims description 3
- 239000002480 mineral oil Substances 0.000 claims description 3
- 239000012875 nonionic emulsifier Substances 0.000 claims description 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 3
- 229920000053 polysorbate 80 Polymers 0.000 claims description 3
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 3
- 239000000230 xanthan gum Substances 0.000 claims description 3
- 229920001285 xanthan gum Polymers 0.000 claims description 3
- 229940082509 xanthan gum Drugs 0.000 claims description 3
- 235000010493 xanthan gum Nutrition 0.000 claims description 3
- 235000005881 Calendula officinalis Nutrition 0.000 claims description 2
- 240000000785 Tagetes erecta Species 0.000 claims description 2
- 240000002657 Thymus vulgaris Species 0.000 claims description 2
- 235000007303 Thymus vulgaris Nutrition 0.000 claims description 2
- 150000001335 aliphatic alkanes Chemical class 0.000 claims description 2
- 239000010775 animal oil Substances 0.000 claims description 2
- 235000020710 ginseng extract Nutrition 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 230000008569 process Effects 0.000 claims description 2
- 229920002545 silicone oil Polymers 0.000 claims description 2
- 239000001585 thymus vulgaris Substances 0.000 claims description 2
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 claims description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 2
- 239000008158 vegetable oil Substances 0.000 claims description 2
- 239000003906 humectant Substances 0.000 claims 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 abstract description 7
- 230000007794 irritation Effects 0.000 abstract description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 239000000839 emulsion Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- QOSMNYMQXIVWKY-UHFFFAOYSA-N Propyl levulinate Chemical compound CCCOC(=O)CCC(C)=O QOSMNYMQXIVWKY-UHFFFAOYSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 125000004492 methyl ester group Chemical group 0.000 description 2
- 241000208340 Araliaceae Species 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000002612 dispersion medium Substances 0.000 description 1
- 238000005485 electric heating Methods 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 239000002569 water oil cream Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/068—Microemulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/21—Emulsions characterized by droplet sizes below 1 micron
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/26—Optical properties
- A61K2800/262—Transparent; Translucent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Emergency Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a microemulsion and a preparation method thereof, wherein the microemulsion comprises the following components in parts by weight: 35-77 parts of water, 2-4 parts of emulsifier, 15-50 parts of organic solvent and 0.5-1 part of arbutin; the invention uses water, emulsifier, organic solvent and arbutin to obtain transparent microemulsion; the added surfactant of the microemulsion is less in dosage and less in irritation; the microemulsion of the invention has good stability.
Description
Technical Field
The invention relates to the technical field of daily chemicals, in particular to microemulsion and a preparation method thereof.
Background
If the diameter of dispersed liquid drops is between 5nm and 100nm after two or more mutually immiscible liquids are mixed and emulsified, the system is called microemulsion. Microemulsions are transparent disperse systems whose formation is related to the solubilization of micelles, also known as "swollen micellar solutions" or "micellar emulsions", microemulsions for short. Microemulsions are generally transparent or translucent liquid stable systems composed of oil, water, surfactants, co-surfactants, and electrolytes, among others. The microemulsion is characterized in that the size of dispersed phase particles is 0.01-0.1 mu m, the particles are uniform and invisible under a microscope; the particles are spherical; the microemulsion is semitransparent or transparent, the thermodynamics is stable, if the system is transparent, the fluidity is good, and the microemulsion is not layered after being separated for five minutes by using the centrifugal acceleration of 100g of a centrifugal machine; is miscible with oil and water in a certain range. The system in which the dispersed phase is oil and the dispersion medium is water is called O/W type microemulsion, and vice versa is called W/O type microemulsion.
In the existing method for preparing the microemulsion, a large amount of surfactant is required to be added to obtain the stable microemulsion, but the microemulsion prepared by the method has great irritation and limits the application of the microemulsion. Some manufacturers also use special equipment to prepare the microemulsion, but the high cost of the process also limits its application.
Disclosure of Invention
In order to solve the problem that a large amount of surfactant is required to be added or special equipment is required to be adopted in the preparation of the existing microemulsion, the invention aims to provide the microemulsion, the dosage of the surfactant in the microemulsion is small, the irritation is small, the stability is good, and components with various effects can be added to obtain different purposes, so that the application range is enlarged; for this reason, the invention also provides a preparation method of the microemulsion.
In order to achieve the purpose, the invention adopts the following technical scheme:
in a first aspect of the present invention, a microemulsion is provided, which comprises the following components in parts by weight: 35-77 parts of water, 2-4 parts of emulsifier, 15-50 parts of organic solvent and 0.5-1 part of arbutin.
Wherein, the oil-water emulsion also comprises 0.5 to 10 weight parts of moistening agent, and the moistening agent is selected from one or a mixture of more of silicone oil, vegetable oil and animal oil alkanes.
Preferably, the moistening agent is one or more of caprylic triglyceride, capric triglyceride, jojoba oil, isooctyl palmitate, mineral oil, sweet almond oil, meadowfoam oil and grape seed oil.
Wherein, the preservative also comprises 0.1 to 0.2 weight part, and the preservative is selected from methyl ester, propyl ester or ethyl ester.
Wherein, the plant extract also comprises 0.1-0.2 weight part of plant extract, and the plant extract is selected from one or more of marigold extract, lavender extract, thyme extract, violet extract and ginseng extract.
Wherein, the coating also comprises 0.1 to 0.2 weight part of thickening agent, and the thickening agent is one or a mixture of xanthan gum, cellulose and carbomer.
Wherein the emulsifier is an anionic emulsifier or a nonionic emulsifier.
Preferably, the emulsifier is one or more selected from hydrogenated castor oil, PEG-20 glucose half stearate, Tween-60 and Tween-80.
Wherein, the organic solvent is selected from one or more of ethanol, propylene glycol and butanediol.
Wherein, the emulsion also comprises 0.5 weight part of a sensitizer.
Preferably, the sumicide is baitamine.
In a second aspect of the present invention, there is provided a method for preparing the above microemulsion, comprising the steps of:
s1, uniformly mixing the emulsifier and arbutin, and adding the mixture into water while stirring;
s2, adding the organic solvent into the system of S1, and stirring until the solution is transparent to obtain the microemulsion.
Compared with the prior art, the invention has the following beneficial effects: the invention uses water, emulsifier, organic solvent and arbutin to obtain transparent microemulsion; the added surfactant of the microemulsion is less in dosage and less in irritation; the microemulsion of the invention has good stability.
Detailed Description
The following description of the embodiments of the present invention is provided for illustrative purposes, and other advantages and effects of the present invention will become apparent to those skilled in the art from the present disclosure.
A microemulsion comprises the following components in parts by weight: 35-77 parts of water, 2-4 parts of emulsifier, 15-50 parts of organic solvent and 0.5-1 part of arbutin.
In the field of daily chemicals, water, an emulsifier and an organic solvent are mixed, and based on the hydrophilic and oleophilic properties of the emulsifier, the three can form a stable emulsion system after being stirred at a high speed, and are dispersed relatively uniformly but not transparent; in order to obtain a clear microemulsion system, the amount of emulsifier needs to be increased. However, the use amount of the emulsifier is increased, so that the irritation is increased, and the use range is limited.
The emulsifier is an anionic emulsifier or a nonionic emulsifier, and when one or more of hydrogenated castor oil, PEG-20 glucose half stearate, Tween-60 and Tween-80 are selected and mixed in the system, the emulsifying effect is better, and the stability of the obtained microemulsion is more durable.
Wherein, the organic solvent is selected from one or more of ethanol, propylene glycol and butanediol.
When the micro-emulsion is used in the field of daily chemicals and the moistening performance and the efficacy need to be improved, a moistening agent and various plant additives can be added into the micro-emulsion, wherein the commonly used moistening agent is one or a mixture of more of caprylic/capric triglyceride, jojoba oil, isooctyl palmitate, mineral oil, sweet almond oil, meadowfoam oil and grape seed oil. The plant additive can be one or more of flos Tagetis Erectae extract, Lavender extract, herba Thymi extract, violet extract, and Ginseng radix extract.
The microemulsion can also be added with a preservative and a thickening agent, wherein the preservative is methyl ester, propyl ester or ethyl ester, and the thickening agent is one or a mixture of xanthan gum, cellulose and carbomer.
The amounts of the components used in examples 1-4 are shown in Table 1.
TABLE 1
The microemulsions prepared in the embodiments 1 to 4 are respectively placed in an electric heating constant temperature incubator at 40 to 50 ℃ for 50 days, and no obvious layering phenomenon is observed after the temperature is recovered, which shows that the microemulsion of the invention has good stability.
The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.
Claims (10)
1. The microemulsion is characterized by comprising the following components in parts by weight: 35-77 parts of water, 2-4 parts of emulsifier, 15-50 parts of organic solvent and 0.5-1 part of arbutin.
2. The microemulsion of claim 1 further comprising 0.5 to 10 parts by weight of a humectant selected from the group consisting of silicone oils, vegetable oils, and mixtures of one or more of animal oil alkanes.
3. The microemulsion of claim 2 wherein the humectant is selected from the group consisting of caprylic triglyceride, capric triglyceride, jojoba oil, isooctyl palmitate, mineral oil, sweet almond oil, meadowfoam oil, grape seed oil, and mixtures thereof.
4. The microemulsion of claim 1 further comprising 0.1 to 0.2 parts by weight of a preservative selected from the group consisting of methyl, propyl or ethyl esters.
5. The microemulsion of claim 1 further comprising 0.1 to 0.2 parts by weight of a plant extract selected from the group consisting of marigold extract, lavender extract, thyme extract, violet extract, ginseng extract, and mixtures thereof.
6. The microemulsion of claim 1 further comprising 0.1 to 0.2 parts by weight of a thickener selected from the group consisting of xanthan gum, cellulose, and carbomer in combination.
7. The microemulsion of any one of claims 1 to 6 wherein the emulsifier is an anionic emulsifier or a nonionic emulsifier.
8. The microemulsion of claim 7 wherein the emulsifier is selected from the group consisting of hydrogenated castor oil, PEG-20 glucose half stearate, Tween-60, Tween-80, and combinations thereof.
9. A microemulsion as claimed in any one of claims 1 to 6 wherein said organic solvent is selected from a mixture of one or more of ethanol, propylene glycol and butylene glycol.
10. A process for the preparation of a microemulsion according to any one of claims 1 to 9, comprising the steps of:
s1, uniformly mixing the emulsifier and arbutin, and adding the mixture into water while stirring;
s2, adding the organic solvent into the system of S1, and stirring until the solution is transparent to obtain the microemulsion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910059531.0A CN111449975A (en) | 2019-01-22 | 2019-01-22 | Microemulsion and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910059531.0A CN111449975A (en) | 2019-01-22 | 2019-01-22 | Microemulsion and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111449975A true CN111449975A (en) | 2020-07-28 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910059531.0A Pending CN111449975A (en) | 2019-01-22 | 2019-01-22 | Microemulsion and preparation method thereof |
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| Country | Link |
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| CN (1) | CN111449975A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112807245A (en) * | 2020-12-31 | 2021-05-18 | 北京化工大学 | Transparent skin care emulsion and preparation method thereof |
| CN115105419A (en) * | 2022-05-19 | 2022-09-27 | 徐州工程学院 | Emulsion capable of collapsing and inhibiting bacterial biofilm and preparation method thereof |
-
2019
- 2019-01-22 CN CN201910059531.0A patent/CN111449975A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112807245A (en) * | 2020-12-31 | 2021-05-18 | 北京化工大学 | Transparent skin care emulsion and preparation method thereof |
| CN115105419A (en) * | 2022-05-19 | 2022-09-27 | 徐州工程学院 | Emulsion capable of collapsing and inhibiting bacterial biofilm and preparation method thereof |
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