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CN111407353A - Novel ligature nail clamp made of fibroin material - Google Patents

Novel ligature nail clamp made of fibroin material Download PDF

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Publication number
CN111407353A
CN111407353A CN202010145767.9A CN202010145767A CN111407353A CN 111407353 A CN111407353 A CN 111407353A CN 202010145767 A CN202010145767 A CN 202010145767A CN 111407353 A CN111407353 A CN 111407353A
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CN
China
Prior art keywords
fixed block
clamping arm
arm
fibroin material
clamp made
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202010145767.9A
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Chinese (zh)
Inventor
邹洪
王涛
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Western Theater General Hospital of PLA
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Individual
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Priority to CN202010145767.9A priority Critical patent/CN111407353A/en
Publication of CN111407353A publication Critical patent/CN111407353A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B17/12Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/122Clamps or clips, e.g. for the umbilical cord
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/18Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/22Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/507Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04Macromolecular materials
    • A61L31/043Proteins; Polypeptides; Degradation products thereof
    • A61L31/047Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B2017/00831Material properties

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Reproductive Health (AREA)
  • Surgical Instruments (AREA)

Abstract

The invention discloses a ligation nail clamp made of a novel fibroin material, which comprises an upper clamp arm and a lower clamp arm which are of an integrated structure, wherein an inner fixed block is fixed at the top of the upper clamp arm, a bottom groove is formed in the bottom surface of the inner fixed block, a mounting groove for the inner fixed block to insert into is formed in the top surface of the lower clamp arm, a limiting column is mounted in the middle of the top end of the inner side of the mounting groove, the limiting column is inserted into the inner side of the bottom groove and connected with the inner fixed block, damping blocks are symmetrically fixed on the inner wall of the bottom groove, each damping block is of a semi-cylindrical structure and is an elastic material component, and the limiting column is connected with the damping blocks in an extrusion; through the interior fixed block and the mounting groove of design, can in use, further increase the steadiness that the ligature pressed from both sides to guarantee in the use in later stage, can not appear dropping or not hard up phenomenon, use more stably, great reduction the limitation of using.

Description

Novel ligature nail clamp made of fibroin material
Technical Field
The invention belongs to the technical field of ligation nail clamps, and particularly relates to a novel ligation nail clamp made of fibroin materials.
Background
Biomedical materials are special materials used for diagnosing, treating, repairing or replacing damaged tissues and organs of organisms and helping tissue growth, animal silk proteins are used as the biomedical materials for hundreds of years, are used as wound sutures at the earliest and are also used for processing in the manufacture of binding nail clamps.
When the existing ligation nail clamp is used, the existing ligation nail clamp is limited and fixed only through a part at the end part, so that the stability is poor, the stability of installation cannot be guaranteed, the phenomenon of loosening and slipping is easy to occur in long-time use, and postoperative recovery and the like are influenced; furthermore, clinical applications are now such as: the Hem-o-lock clamp often has the phenomenon of loosening, falling off and clamping a clamping forceps due to the problem of material, is not absorbable in vivo, is equivalent to a foreign matter, and is easy to cause the phenomena of vessel rupture bleeding, gastrointestinal tract perforation and the like caused by the compression of vessels and visceral organs due to the wrapping and pressing of tissues around inflammatory reaction, so that a biological material is urgently needed for improvement.
Disclosure of Invention
The invention aims to provide a novel ligation nail clip made of fibroin materials, which aims to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme: the utility model provides a novel ligature nail clamp of fibroin material preparation, includes the last arm lock and lower arm lock of integral type structure, the top of going up the arm lock is fixed with interior fixed block, the kerve has been seted up on the bottom surface of interior fixed block, fixed block male mounting groove in supplying is seted up to the top surface of lower arm lock, the inboard top middle part department of mounting groove installs spacing post, the inboard and interior fixed block that spacing post inserted the kerve are connected.
Preferably, the inner wall symmetry of kerve is fixed with the damping piece, the damping piece is the half cylinder structure, the damping piece is elastic material component, spacing post is connected with the extrusion laminating of damping piece.
Preferably, the surfaces of the limiting column and the lower clamping arm are positioned on the same curved surface, and the width of the limiting column is six-seventh of the width of the inner side of the bottom groove.
Preferably, arc edges are formed at four corners of the limiting column and connected with the surface of the damping block in an extrusion mode.
Preferably, a plurality of limiting protrusions are arranged on the bottom surface of the upper clamping arm and the top surface of the lower clamping arm at equal distances, and each limiting protrusion is of a hemispherical structure.
Preferably, the limiting protrusions on the surfaces of the upper clamping arm and the lower clamping arm are distributed in a dog-tooth staggered manner, and the material of the limiting protrusions is the same as that of the upper clamping arm.
Preferably, the joint of the upper clamping arm and the limiting bulge is provided with a side groove in an arc structure, and the width of the side groove is one third of the width of the joint of the lower clamping arm and the upper clamping arm.
Preferably, the top of going up the arm lock is installed spacing cutting ferrule, the tip of arm lock is installed the arc hook of card income spacing cutting ferrule inboard down.
Compared with the prior art, the invention has the beneficial effects that:
1. by the designed inner fixing block and the mounting groove, the stability of the ligation clip can be further improved in use, so that the phenomenon of falling or loosening can be avoided in later use, the ligation clip is more stable in use, and the use limitation is greatly reduced;
2. the artificial blood vessel made of silk fiber can prevent blood from permeating, so that early thrombosis is avoided, silk protein has the characteristics of good biocompatibility, low immunogenicity, processability, degradability and the like, and can be used for preparing biological materials with excellent performance, the biological safety, degradability, immunogenicity and excellent mechanical structure of the silk protein material are realized, and silk in China is abundant in production area and low in price;
3. through the designed limiting protrusion, slight displacement of the clamped part can be avoided in clamping, and the position can not be changed after installation.
Drawings
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a schematic view of the connection between the inner fixing block and the limiting block according to the present invention;
FIG. 3 is a top view of the lower clamp arm of the present invention;
FIG. 4 is a schematic structural view of a spacing post according to the present invention;
FIG. 5 is a schematic view of the upper and lower clamp arms of the present invention;
in the figure: 1. a limiting clamping sleeve; 2. an upper clamping arm; 3. a side groove; 4. a limiting bulge; 5. a lower clamping arm; 6. an inner fixed block; 7. a bottom groove; 9. a damping block; 10. a limiting column; 11. mounting grooves; 12. and (4) an arc-shaped edge.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
Referring to fig. 1 to 4, the present invention provides a technical solution: the utility model provides a novel ligature nail clamp of fibroin material preparation, last arm lock 2 and lower arm lock 5 including the integral type structure, the top of going up arm lock 2 is fixed with interior fixed block 6, kerve 7 has been seted up on the bottom surface of interior fixed block 6, lower arm lock 5's top surface has been seted up and has been supplied interior fixed block 6 male mounting groove 11, interior fixed block 6 and mounting groove 11 through the design, can in use, further increase the steadiness that the ligature pressed from both sides, thereby guarantee in the use in later stage, the phenomenon that drops or become flexible can not appear, use more stably, great reduction the limitation of using, spacing post 10 is installed to the inboard top middle part department of mounting groove 11, spacing post 10 inserts the inboard and the interior fixed block 6 of kerve 7 and is connected.
In this embodiment, preferably, the damping blocks 9 are symmetrically fixed on the inner wall of the bottom slot 7, the damping blocks 9 are in a semi-cylindrical structure, the damping blocks 9 are elastic members, the limiting columns 10 are connected with the damping blocks 9 in an extrusion and fitting manner, the upper clamping arms 2, the lower clamping arms 5, the inner fixing blocks 6 and the damping blocks 9 are made of silk, and the artificial blood vessel made of silk fibers can prevent blood from permeating, so that early thrombosis is avoided.
In this embodiment, preferably, the surfaces of the limiting column 10 and the lower clamping arm 5 are on the same curved surface, and the width of the limiting column 10 is six-seventeenth of the width of the inner side of the bottom slot 7.
In this embodiment, preferably, the four corners of the limiting column 10 are formed with arc-shaped edges 12, and the arc-shaped edges 12 are connected with the surface of the damping block 9 in a pressing manner.
In this embodiment, preferably, the top of the upper clamping arm 2 is provided with a limiting clamping sleeve 1, and the end of the lower clamping arm 5 is provided with an arc-shaped hook clamped into the inner side of the limiting clamping sleeve 1.
Example 2
Referring to fig. 1 to 5, the present invention provides a technical solution: the utility model provides a novel ligature nail clamp of fibroin material preparation, last arm lock 2 and lower arm lock 5 including the integral type structure, the top of going up arm lock 2 is fixed with interior fixed block 6, kerve 7 has been seted up on the bottom surface of interior fixed block 6, lower arm lock 5's top surface has been seted up and has been supplied interior fixed block 6 male mounting groove 11, interior fixed block 6 and mounting groove 11 through the design, can in use, further increase the steadiness that the ligature pressed from both sides, thereby guarantee in the use in later stage, the phenomenon that drops or become flexible can not appear, use more stably, great reduction the limitation of using, spacing post 10 is installed to the inboard top middle part department of mounting groove 11, spacing post 10 inserts the inboard and the interior fixed block 6 of kerve 7 and is connected.
In this embodiment, preferably, the damping blocks 9 are symmetrically fixed on the inner wall of the bottom slot 7, the damping blocks 9 are in a semi-cylindrical structure, the damping blocks 9 are elastic members, the limiting columns 10 are connected with the damping blocks 9 in an extrusion and fitting manner, the upper clamping arms 2, the lower clamping arms 5, the inner fixing blocks 6 and the damping blocks 9 are made of silk, and the artificial blood vessel made of silk fibers can prevent blood from permeating, so that early thrombosis is avoided.
In this embodiment, preferably, the surfaces of the limiting column 10 and the lower clamping arm 5 are on the same curved surface, and the width of the limiting column 10 is six-seventeenth of the width of the inner side of the bottom slot 7.
In this embodiment, preferably, the four corners of the limiting column 10 are formed with arc-shaped edges 12, and the arc-shaped edges 12 are connected with the surface of the damping block 9 in a pressing manner.
In this embodiment, preferably, the bottom surface of the upper clamping arm 2 and the top surface of the lower clamping arm 5 are provided with a plurality of limiting protrusions 4 at equal distances, and by means of the designed limiting protrusions 4, the clamped parts can be prevented from slightly displacing in clamping, so that the positions of the clamping parts can not be changed after installation, and the limiting protrusions 4 are of a hemispherical structure.
In this embodiment, preferably, the limiting protrusions 4 on the surfaces of the upper clamping arm 2 and the lower clamping arm 5 are distributed in a dog-tooth staggered manner, and the material of the limiting protrusions 4 is the same as that of the upper clamping arm 2.
In this embodiment, preferably, a side groove 3 having an arc-shaped structure is formed at a connection portion of the upper clamping arm 2 and the limiting protrusion 4, and a width of the side groove 3 is one third of a width of a connection portion of the lower clamping arm 5 and the upper clamping arm 2.
In this embodiment, preferably, the top of the upper clamping arm 2 is provided with a limiting clamping sleeve 1, and the end of the lower clamping arm 5 is provided with an arc-shaped hook clamped into the inner side of the limiting clamping sleeve 1.
The working principle and the using process of the invention are as follows: when the invention is used, the silk for manufacturing the ligation nail clip not only has good mechanical property, but also has the characteristics of good permeability, biocompatibility, controllable biodegradability and the like, so that the silk has great application value in the directions of tissue engineering, drug loading systems, dressings and the like, the mechanical property of the silk is similar to that of biological tendons, the mechanical form of a pre-formed new tissue can be maintained in the application of the tissue engineering, the silk has no sensitization, irritation and genetic toxicity, the obvious inflammatory reaction can not be caused when the silk is implanted into a body, the cytotoxicity of a tubular bracket prepared by silk fibroin is very low, the silk fibroin and polylactic acid composite bracket can be used for culturing fibroblasts and promoting the growth and proliferation of cells, the proliferation of endothelial cells can be promoted by the silk fibroin, and the anticoagulant function is realized by the special amino acid arrangement structure in the silk fibroin, compared with synthetic materials, the silk protein scaffold (comprising a three-dimensional porous scaffold, nanofibers, hydrogel, a two-dimensional membrane and the like) and the silk protein drug carrier with various forms are applied to the repair of organ tissues such as hard bones, ligaments, skin, cardiovascular, cartilage, cornea, nerves and the like and anticancer therapy, which are the hot subjects of the research in the field of biomaterials in recent years, in use, an upper clamping arm 2 and a lower clamping arm 5 are placed in a ligation clamp, a limiting clamping sleeve 1 at the end part of the upper clamping arm 2 and a clamping hook at the end part of the lower clamping arm 5 are closed and fixed in a closing process, meanwhile, an inner fixing block 6 at the inner side of the top part of the upper clamping arm 2 is embedded into an installation groove 11, a limiting column 10 in the installation groove 11 is clamped into a bottom groove 7, and in the closing process of the upper clamping arm 2 and the lower clamping arm 5, the inner fixing block 6 is gradually inserted into the installation groove 11, spacing post 10 continuously shifts up, and extrude damping piece 9, in the extrusion, reduce through arc limit 12 and damping piece 9 between wearing and tearing, damping piece 9 atress warp, it is spacing with spacing post 10 after damping piece 9's top is removed to whole spacing post 10, with this stability of increasing the installation, after last arm lock 2 is closed completely with lower arm lock 5, spacing arch 4 of both inboards is dog-tooth and is crisscross, every spacing arch 4 on going up arm lock 2 is in the clearance between per two spacing archs 4 on the arm lock 5 down promptly, thereby accomplish spacing to the object, avoid appearing the phenomenon of displacement.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (8)

1. The utility model provides a novel ligature nail of fibroin material preparation presss from both sides, includes last arm lock (2) and lower arm lock (5) of integral type structure, its characterized in that: go up the top of arm lock (2) and be fixed with interior fixed block (6), kerve (7) have been seted up on the bottom surface of interior fixed block (6), the top surface of arm lock (5) is seted up down and is supplied interior fixed block (6) male mounting groove (11), spacing post (10) are installed to the inboard top middle part department of mounting groove (11), the inboard that spacing post (10) inserted kerve (7) is connected with interior fixed block (6).
2. The novel ligature nail clamp made of fibroin material as claimed in claim 1, wherein: the inner wall symmetry of kerve (7) is fixed with damping piece (9), damping piece (9) are the half cylinder structure, damping piece (9) are elastic material component, spacing post (10) are connected with damping piece (9) extrusion laminating.
3. The novel ligature nail clamp made of fibroin material as claimed in claim 1, wherein: the surfaces of the limiting column (10) and the lower clamping arm (5) are positioned on the same curved surface, and the width of the limiting column (10) is six-seventeen of the width of the inner side of the bottom groove (7).
4. The novel ligature nail clamp made of fibroin material as claimed in claim 3, wherein: the four corners of the limiting column (10) are provided with arc-shaped edges (12), and the arc-shaped edges (12) are connected with the surface of the damping block (9) in an extrusion manner.
5. The novel ligature nail clamp made of fibroin material as claimed in claim 1, wherein: the bottom surface of going up arm lock (2) and the top surface of lower arm lock (5) on the equidistance be provided with a plurality of spacing archs (4), spacing arch (4) are the hemisphere structure.
6. The novel ligature nail clamp made of fibroin material as claimed in claim 5, wherein: the limiting protrusions (4) on the surfaces of the upper clamping arm (2) and the lower clamping arm (5) are distributed in a dog-tooth staggered manner, and the material of the limiting protrusions (4) is the same as that of the upper clamping arm (2).
7. The novel ligature nail clamp made of fibroin material as claimed in claim 1, wherein: the joint of the upper clamping arm (2) and the limiting protrusion (4) is provided with a side groove (3) which is of an arc structure, and the width of the side groove (3) is one third of the width of the joint of the lower clamping arm (5) and the upper clamping arm (2).
8. The novel ligature nail clamp made of fibroin material as claimed in claim 7, wherein: go up the top of arm lock (2) and install spacing cutting ferrule (1), the tip of arm lock (5) is installed down and is gone into the inboard arc hook of spacing cutting ferrule (1) of card.
CN202010145767.9A 2020-02-26 2020-02-26 Novel ligature nail clamp made of fibroin material Pending CN111407353A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202010145767.9A CN111407353A (en) 2020-02-26 2020-02-26 Novel ligature nail clamp made of fibroin material

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202010145767.9A CN111407353A (en) 2020-02-26 2020-02-26 Novel ligature nail clamp made of fibroin material

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CN111407353A true CN111407353A (en) 2020-07-14

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Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102892880A (en) * 2010-01-14 2013-01-23 奥加诺吉尼西斯公司 Bioengineered tissue constructs and methods for producing and using thereof
CN103549985A (en) * 2013-10-29 2014-02-05 杭州铭众生物科技有限公司 Absorbable ligature clamp and manufacturing method thereof
CN103961149A (en) * 2013-01-25 2014-08-06 柯惠Lp公司 Foam applied to stapling device
CN104582589A (en) * 2012-08-22 2015-04-29 柯惠Lp公司 Tissue fixation device
CN204765788U (en) * 2015-07-03 2015-11-18 桐庐洲济医疗器械有限公司 Disposable ligature is pressed from both sides
CN105457096A (en) * 2015-12-27 2016-04-06 泉州市奈斯材料科技有限公司 Preparation method of a kind of good biocompatibility and degradable tussah silk fibroin tissue engineering scaffold material
CN206934138U (en) * 2016-12-30 2018-01-30 四川国纳科技有限公司 A kind of ligation clip
CN109620343A (en) * 2018-12-15 2019-04-16 华融科创生物科技(天津)有限公司 Capilary ligation clip

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102892880A (en) * 2010-01-14 2013-01-23 奥加诺吉尼西斯公司 Bioengineered tissue constructs and methods for producing and using thereof
CN104582589A (en) * 2012-08-22 2015-04-29 柯惠Lp公司 Tissue fixation device
CN103961149A (en) * 2013-01-25 2014-08-06 柯惠Lp公司 Foam applied to stapling device
CN103549985A (en) * 2013-10-29 2014-02-05 杭州铭众生物科技有限公司 Absorbable ligature clamp and manufacturing method thereof
CN204765788U (en) * 2015-07-03 2015-11-18 桐庐洲济医疗器械有限公司 Disposable ligature is pressed from both sides
CN105457096A (en) * 2015-12-27 2016-04-06 泉州市奈斯材料科技有限公司 Preparation method of a kind of good biocompatibility and degradable tussah silk fibroin tissue engineering scaffold material
CN206934138U (en) * 2016-12-30 2018-01-30 四川国纳科技有限公司 A kind of ligation clip
CN109620343A (en) * 2018-12-15 2019-04-16 华融科创生物科技(天津)有限公司 Capilary ligation clip

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