CN111377729A - Environment-friendly biological ceramic material and preparation method thereof - Google Patents
Environment-friendly biological ceramic material and preparation method thereof Download PDFInfo
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Abstract
The invention discloses an environment-friendly biological ceramic material which comprises the following raw materials in parts by weight: hydroxyapatite, zirconium dioxide, fluorapatite, calcium phosphate, aluminum phosphate, microcrystalline cellulose, nano titanium dioxide, nano silicon oxide, nano zinc oxide, carboxymethyl cellulose, acrylic resin, PEG-150 stearate, polydimethylsiloxane, carbon powder and distilled water. The preparation method of the biological ceramic material comprises the following steps: spraying fluorapatite between the zirconium dioxide and the hydroxyapatite, adding calcium phosphate, aluminum phosphate, nano titanium dioxide, distilled water and the like, and ball-milling; then adding microcrystalline cellulose and the like for ball milling; defoaming, molding, and sintering. The biological ceramic material has excellent biocompatibility and bioactivity, contains no toxic and harmful substances, is beneficial to health, has high strength, excellent performances such as hardness, flexural modulus, compressive strength and flexural strength, is simple to prepare, has low cost and wide application range, and can be used for preparing various biological ceramic materials.
Description
Technical Field
The invention relates to the technical field of biological materials, in particular to an environment-friendly biological ceramic material and a preparation method thereof.
Background
Bioceramics refers broadly to ceramic materials associated with living organisms or biochemistry and refers to a class of ceramic materials used as specific biological or physiological functions, i.e., ceramic materials used directly in the human body or in biological, medical, biochemical, etc. associated with the human body. As an inorganic biomedical material, the material has the advantages of good compatibility and excellent affinity with biological tissues, stable physicochemical property, sterilizability, nontoxicity and the like, and is increasingly paid more attention by people. In the prior art, the biological ceramic material is compounded with other materials due to the mechanical property, stability, biocompatibility and other properties of the biological ceramic material, so that the advantages of the biological ceramic material are highlighted, and the application of the biological ceramic material is expanded, thereby becoming a hotspot for research and development of a plurality of enterprises and students.
Disclosure of Invention
The invention aims to overcome the technical defects and provides an environment-friendly biological ceramic material and a preparation method thereof.
In order to achieve the purpose of the invention, the invention adopts the technical scheme that: an environment-friendly biological ceramic material comprises the following raw materials in parts by weight: 10-20 parts of hydroxyapatite, 5-10 parts of zirconium dioxide, 5-10 parts of fluorapatite, 10-12 parts of calcium phosphate, 8-13 parts of aluminum phosphate, 6-8 parts of microcrystalline cellulose, 3-5 parts of nano titanium dioxide, 3-5 parts of nano silicon oxide, 3-5 parts of nano zinc oxide, 1-5 parts of carboxymethyl cellulose, 1-5 parts of acrylic resin, 1-3 parts of PEG-150 stearate, 1-3 parts of polydimethylsiloxane, 5-8 parts of carbon powder and 50-100 parts of distilled water.
Further, the environment-friendly biological ceramic material comprises the following raw materials in parts by weight: 15 parts of hydroxyapatite, 8 parts of zirconium dioxide, 8 parts of fluorapatite, 11 parts of calcium phosphate, 10 parts of aluminum phosphate, 7 parts of microcrystalline cellulose, 4 parts of nano titanium dioxide, 4 parts of nano silicon oxide, 4 parts of nano zinc oxide, 3 parts of carboxymethyl cellulose, 3 parts of acrylic resin, 2 parts of PEG-150 stearate, 2 parts of polydimethylsiloxane, 7 parts of carbon powder and 80 parts of distilled water.
The preparation method of the environment-friendly biological ceramic material comprises the following preparation steps:
(1) putting zirconium dioxide and hydroxyapatite into a container, spraying fluorapatite on the zirconium dioxide and hydroxyapatite, and standing the mixture for later use; the fluorapatite is sprayed between the zirconium dioxide and the hydroxyapatite, and the fluorapatite is stable at high temperature, so that the reaction of the hydroxyapatite and the zirconium dioxide can be prevented, because the reaction of the hydroxyapatite and the zirconium dioxide not only reduces the mechanical property of the material, but also reduces the biocompatibility of the material.
(2) Mixing the raw materials treated in the step (1), calcium phosphate, aluminum phosphate, nano titanium dioxide, nano silicon oxide, nano zinc oxide, carbon powder and distilled water, and pouring the mixture into a ball mill for ball milling for 0.5 to 1 hour;
(3) adding microcrystalline cellulose, carboxymethyl cellulose and acrylic resin, and continuing ball milling for 0.5-1 h;
(4) adding PEG-150 stearate and polydimethylsiloxane for defoaming treatment;
(5) filling the mixture into a graphite mold;
(6) and (3) placing the mould filled with the mixture into a discharge plasma sintering device for low-temperature rapid sintering, and naturally cooling after sintering to obtain a finished product.
Further, the rotating speed of the ball mill in the step (2) is 150 r/min.
Further, in the step (6), the sintering temperature is 1200 ℃, and the sintering heat preservation time is 20 min.
The invention has the beneficial effects that: the biological ceramic material provided by the invention has excellent biocompatibility and bioactivity, the prepared environment-friendly ceramic material does not contain toxic and harmful substances, is beneficial to health, has high strength, excellent performances such as hardness, flexural modulus, compressive strength and flexural strength, is simple to prepare, has low cost and is wide in application range.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments of the present invention, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example one
An environment-friendly biological ceramic material comprises the following raw materials in parts by weight: 10 parts of hydroxyapatite, 5 parts of zirconium dioxide, 5 parts of fluorapatite, 10 parts of calcium phosphate, 8 parts of aluminum phosphate, 6 parts of microcrystalline cellulose, 3 parts of nano titanium dioxide, 3 parts of nano silicon oxide, 3 parts of nano zinc oxide, 1 part of carboxymethyl cellulose, 1 part of acrylic resin, 1 part of PEG-150 stearate, 1 part of polydimethylsiloxane, 5 parts of carbon powder and 50 parts of distilled water. The preparation method of the environment-friendly biological ceramic material comprises the following preparation steps:
(1) putting zirconium dioxide and hydroxyapatite into a container, spraying fluorapatite on the zirconium dioxide and hydroxyapatite, and standing the mixture for later use; the fluorapatite is sprayed between the zirconium dioxide and the hydroxyapatite, and the fluorapatite is stable at high temperature, so that the reaction of the hydroxyapatite and the zirconium dioxide can be prevented, because the reaction of the hydroxyapatite and the zirconium dioxide not only reduces the mechanical property of the material, but also reduces the biocompatibility of the material.
(2) Mixing the raw materials treated in the step (1), calcium phosphate, aluminum phosphate, nano titanium dioxide, nano silicon oxide, nano zinc oxide, carbon powder and distilled water, pouring the mixture into a ball mill for ball milling for 0.5h, wherein the rotating speed of the ball mill is 150 r/min;
(3) adding microcrystalline cellulose, carboxymethyl cellulose and acrylic resin, and continuing ball milling for 0.5 h;
(4) adding PEG-150 stearate and polydimethylsiloxane for defoaming treatment;
(5) filling the mixture into a graphite mold;
(6) and (3) placing the mould filled with the mixture into a spark plasma sintering device for low-temperature rapid sintering, wherein the sintering temperature is 1200 ℃, the sintering heat preservation time is 20min, and naturally cooling after sintering is finished to obtain a finished product.
Example two
An environment-friendly biological ceramic material comprises the following raw materials in parts by weight: 15 parts of hydroxyapatite, 8 parts of zirconium dioxide, 8 parts of fluorapatite, 11 parts of calcium phosphate, 10 parts of aluminum phosphate, 7 parts of microcrystalline cellulose, 4 parts of nano titanium dioxide, 4 parts of nano silicon oxide, 4 parts of nano zinc oxide, 3 parts of carboxymethyl cellulose, 3 parts of acrylic resin, 2 parts of PEG-150 stearate, 2 parts of polydimethylsiloxane, 7 parts of carbon powder and 80 parts of distilled water. The preparation method of the environment-friendly biological ceramic material comprises the following preparation steps:
(1) putting zirconium dioxide and hydroxyapatite into a container, spraying fluorapatite on the zirconium dioxide and hydroxyapatite, and standing the mixture for later use; the fluorapatite is sprayed between the zirconium dioxide and the hydroxyapatite, and the fluorapatite is stable at high temperature, so that the reaction of the hydroxyapatite and the zirconium dioxide can be prevented, because the reaction of the hydroxyapatite and the zirconium dioxide not only reduces the mechanical property of the material, but also reduces the biocompatibility of the material.
(2) Mixing the raw materials treated in the step (1), calcium phosphate, aluminum phosphate, nano titanium dioxide, nano silicon oxide, nano zinc oxide, carbon powder and distilled water, pouring the mixture into a ball mill for ball milling for 1 hour, wherein the rotating speed of the ball mill is 150 r/min;
(3) adding microcrystalline cellulose, carboxymethyl cellulose and acrylic resin, and continuing ball milling for 0.5 h;
(4) adding PEG-150 stearate and polydimethylsiloxane for defoaming treatment;
(5) filling the mixture into a graphite mold;
(6) and (3) placing the mould filled with the mixture into a spark plasma sintering device for low-temperature rapid sintering, wherein the sintering temperature is 1200 ℃, the sintering heat preservation time is 20min, and naturally cooling after sintering is finished to obtain a finished product.
EXAMPLE III
An environment-friendly biological ceramic material comprises the following raw materials in parts by weight: 20 parts of hydroxyapatite, 10 parts of zirconium dioxide, 10 parts of fluorapatite, 12 parts of calcium phosphate, 13 parts of aluminum phosphate, 8 parts of microcrystalline cellulose, 5 parts of nano titanium dioxide, 5 parts of nano silicon oxide, 5 parts of nano zinc oxide, 5 parts of carboxymethyl cellulose, 5 parts of acrylic resin, 3 parts of PEG-150 stearate, 3 parts of polydimethylsiloxane, 8 parts of carbon powder and 100 parts of distilled water. The preparation method of the environment-friendly biological ceramic material comprises the following preparation steps:
(1) putting zirconium dioxide and hydroxyapatite into a container, spraying fluorapatite on the zirconium dioxide and hydroxyapatite, and standing the mixture for later use; the fluorapatite is sprayed between the zirconium dioxide and the hydroxyapatite, and the fluorapatite is stable at high temperature, so that the reaction of the hydroxyapatite and the zirconium dioxide can be prevented, because the reaction of the hydroxyapatite and the zirconium dioxide not only reduces the mechanical property of the material, but also reduces the biocompatibility of the material.
(2) Mixing the raw materials treated in the step (1), calcium phosphate, aluminum phosphate, nano titanium dioxide, nano silicon oxide, nano zinc oxide, carbon powder and distilled water, pouring the mixture into a ball mill for ball milling for 1 hour, wherein the rotating speed of the ball mill is 150 r/min;
(3) adding microcrystalline cellulose, carboxymethyl cellulose and acrylic resin, and continuing ball milling for 1 h;
(4) adding PEG-150 stearate and polydimethylsiloxane for defoaming treatment;
(5) filling the mixture into a graphite mold;
(6) and (3) placing the mould filled with the mixture into a spark plasma sintering device for low-temperature rapid sintering, wherein the sintering temperature is 1200 ℃, the sintering heat preservation time is 20min, and naturally cooling after sintering is finished to obtain a finished product.
The present invention and the embodiments thereof have been described above, but the description is not limited to the embodiments, but only one of the embodiments of the present invention, and the actual embodiments are not limited thereto. In conclusion, those skilled in the art should appreciate that they can readily use the disclosed conception and specific embodiments as a basis for designing or modifying other structures for carrying out the same purposes of the present invention without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (5)
1. An environment-friendly biological ceramic material is characterized in that: the feed comprises the following raw materials in parts by weight: 10-20 parts of hydroxyapatite, 5-10 parts of zirconium dioxide, 5-10 parts of fluorapatite, 10-12 parts of calcium phosphate, 8-13 parts of aluminum phosphate, 6-8 parts of microcrystalline cellulose, 3-5 parts of nano titanium dioxide, 3-5 parts of nano silicon oxide, 3-5 parts of nano zinc oxide, 1-5 parts of carboxymethyl cellulose, 1-5 parts of acrylic resin, 1-3 parts of PEG-150 stearate, 1-3 parts of polydimethylsiloxane, 5-8 parts of carbon powder and 50-100 parts of distilled water.
2. The environment-friendly bioceramic material of claim 1, wherein: the feed comprises the following raw materials in parts by weight: 15 parts of hydroxyapatite, 8 parts of zirconium dioxide, 8 parts of fluorapatite, 11 parts of calcium phosphate, 10 parts of aluminum phosphate, 7 parts of microcrystalline cellulose, 4 parts of nano titanium dioxide, 4 parts of nano silicon oxide, 4 parts of nano zinc oxide, 3 parts of carboxymethyl cellulose, 3 parts of acrylic resin, 2 parts of PEG-150 stearate, 2 parts of polydimethylsiloxane, 7 parts of carbon powder and 80 parts of distilled water.
3. The preparation method of the environment-friendly biological ceramic material is characterized by comprising the following steps: the preparation method comprises the following preparation steps:
(1) putting zirconium dioxide and hydroxyapatite into a container, spraying fluorapatite on the zirconium dioxide and hydroxyapatite, and standing the mixture for later use;
(2) mixing the raw materials treated in the step (1), calcium phosphate, aluminum phosphate, nano titanium dioxide, nano silicon oxide, nano zinc oxide, carbon powder and distilled water, and pouring the mixture into a ball mill for ball milling for 0.5 to 1 hour;
(3) adding microcrystalline cellulose, carboxymethyl cellulose and acrylic resin, and continuing ball milling for 0.5-1 h;
(4) adding PEG-150 stearate and polydimethylsiloxane for defoaming treatment;
(5) filling the mixture into a graphite mold;
(6) and (3) placing the mould filled with the mixture into a discharge plasma sintering device for low-temperature rapid sintering, and naturally cooling after sintering to obtain a finished product.
4. The method for preparing the environment-friendly biological ceramic material as claimed in claim 3, wherein the method comprises the following steps: the rotating speed of the ball mill in the step (2) is 150 r/min.
5. The environment-friendly biological ceramic material and the preparation method thereof as claimed in claim 3, wherein: in the step (6), the sintering temperature is 1200 ℃, and the sintering heat preservation time is 20 min.
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