CN111359553B - Preparation method of biodegradable edible pigment microcapsule - Google Patents
Preparation method of biodegradable edible pigment microcapsule Download PDFInfo
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- 239000000049 pigment Substances 0.000 title claims abstract description 37
- 239000003094 microcapsule Substances 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 65
- 238000003756 stirring Methods 0.000 claims abstract description 36
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims abstract description 27
- 238000010438 heat treatment Methods 0.000 claims abstract description 25
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000008367 deionised water Substances 0.000 claims abstract description 18
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 18
- 229920000642 polymer Polymers 0.000 claims abstract description 18
- 238000006243 chemical reaction Methods 0.000 claims abstract description 17
- 229920000747 poly(lactic acid) Polymers 0.000 claims abstract description 14
- 239000004626 polylactic acid Substances 0.000 claims abstract description 14
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 9
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 claims abstract description 9
- 229920004890 Triton X-100 Polymers 0.000 claims abstract description 9
- 239000013504 Triton X-100 Substances 0.000 claims abstract description 9
- 229910052786 argon Inorganic materials 0.000 claims abstract description 9
- 235000012730 carminic acid Nutrition 0.000 claims abstract description 9
- 239000004005 microsphere Substances 0.000 claims abstract description 9
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 9
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract description 9
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims abstract description 9
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims abstract description 9
- USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 claims abstract description 9
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 claims abstract description 9
- RRHXZLALVWBDKH-UHFFFAOYSA-M trimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azanium;chloride Chemical compound [Cl-].CC(=C)C(=O)OCC[N+](C)(C)C RRHXZLALVWBDKH-UHFFFAOYSA-M 0.000 claims abstract description 9
- 239000012071 phase Substances 0.000 claims description 56
- 238000002156 mixing Methods 0.000 claims description 29
- 238000005303 weighing Methods 0.000 claims description 24
- 239000008346 aqueous phase Substances 0.000 claims description 16
- 238000001816 cooling Methods 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 8
- 238000001914 filtration Methods 0.000 claims description 8
- 238000002386 leaching Methods 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 8
- 239000000725 suspension Substances 0.000 claims description 8
- 238000010557 suspension polymerization reaction Methods 0.000 claims description 8
- 230000001988 toxicity Effects 0.000 abstract description 6
- 231100000419 toxicity Toxicity 0.000 abstract description 6
- 239000000203 mixture Substances 0.000 abstract 3
- 239000000576 food coloring agent Substances 0.000 abstract 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 abstract 1
- 229920000053 polysorbate 80 Polymers 0.000 abstract 1
- 239000000463 material Substances 0.000 description 6
- 229920000136 polysorbate Polymers 0.000 description 4
- 210000000056 organ Anatomy 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 150000004982 aromatic amines Chemical class 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 239000000989 food dye Substances 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 229920002988 biodegradable polymer Polymers 0.000 description 1
- 239000004621 biodegradable polymer Substances 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/14—Polymerisation; cross-linking
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Abstract
一种生物降解食用色素微胶囊的制备方法，步骤如下：取聚乳酸和二氯甲烷放入反应容器搅拌，放置于水浴锅中加热，加入聚乙烯吡咯烷酮和曲拉通X‑100，得到油相体系；取甲基丙烯酰氧乙基三甲基氯化铵、去离子水、过硫酸钾、亚硫酸氢钠混合后通氩气，然后加入胭脂红混合均匀投入反应器中搅拌均匀，得到W/O内水相体系；取聚乙烯醇、Tween‑80和去离子水混合搅拌均匀，得到外水相体系；将W/O内水相体系加入至外水相体系，在450r/min的转速下持续搅拌至体系稳定，然后降温至室温，过滤得到球体，用热水对球体进行淋洗，真空干燥后得到彩色聚合物微球，即生物降解食用色素微胶囊。本发明制备的微胶囊旨在降低偶氮色素的毒性。A preparation method of biodegradable food coloring microcapsules, the steps are as follows: take polylactic acid and dichloromethane and put them into a reaction vessel and stir, place them in a water bath for heating, add polyvinylpyrrolidone and triton X-100 to obtain an oil phase system; get methacryloyloxyethyl trimethyl ammonium chloride, deionized water, potassium persulfate, sodium bisulfite and mix them with argon, then add carmine and mix them evenly into the reactor and stir to obtain W /O inner water phase system; take polyvinyl alcohol, Tween-80 and deionized water and mix and stir evenly to obtain outer water phase system; add W/O inner water phase system to outer water phase system, rotate at a speed of 450r/min Stir continuously until the system is stable, then cool down to room temperature, filter to obtain spheres, rinse the spheres with hot water, and vacuum dry to obtain colored polymer microspheres, namely biodegradable food coloring microcapsules. The microcapsules prepared by the present invention aim to reduce the toxicity of azo pigments.
Description
Technical Field
The invention relates to a preparation method of a biodegradable food pigment microcapsule.
Background
Azo edible pigments have simple structure, bright color, low price and excellent performance, and are widely applied to the fields of food, medicine, cosmetics and the like. However, researches show that some azo pigments can be decomposed in human bodies to form a plurality of aromatic amines, and the aromatic amines can directly act with human cells through in-vivo metabolic activities, possibly cause cell canceration and harm the health of human bodies. Therefore, in order to reduce the physiological toxicity of azo edible pigments, the stable pigment microcapsule particles can be prepared by using the polymer material as the wall material, and the toxicity of the azo pigments is reduced by fully utilizing the physiological safety and stability of the polymer of the microcapsule wall material and the characteristic of non-absorption by the digestive system of an animal.
Disclosure of Invention
The invention aims to solve the technical problem of providing a preparation method of a biodegradable food pigment microcapsule, and the microcapsule prepared by the method aims at reducing the toxicity of azo pigment and improving the safety of the food pigment.
In order to solve the technical problem, the invention provides a preparation method of a biodegradable food pigment microcapsule, which comprises the following steps:
(1) weighing 0.8-1.5g of polylactic acid and 50mL of dichloromethane, mixing, putting into a reaction vessel, starting stirring, putting the reaction vessel into a water bath, heating to 50 ℃, and then adding 2g of polyvinylpyrrolidone and 0.75g of triton X-100 to obtain an oil phase system;
(2) weighing 4-10mL of methacryloyloxyethyl trimethyl ammonium chloride, 7-12.5mL of deionized water, 0.03-0.075g of potassium persulfate and 0.06-0.15g of sodium bisulfite, mixing, introducing argon for 30min, heating to 30 ℃, keeping the temperature for 5h, adding 0.25-0.1g of carmine, uniformly mixing, and putting into the reactor in the step (1); finally, stirring uniformly at the rotating speed of 400r/min to enable the water phase to form uniform liquid drops to be dispersed in the oil phase system, and obtaining a W/O internal water phase system;
(3) weighing 2.5-7.5g of polyvinyl alcohol, 1.25-1.32 g of Tween-800.5 and 300mL of deionized water, and uniformly stirring at a rotating speed of 400r/min to obtain an external water phase system; adding the W/O internal aqueous phase system obtained in the step (2) into an external aqueous phase system to obtain a W/O/W reversed-phase suspension polymerization system;
(4) continuously stirring the W/O/W reversed phase suspension polymer system at the rotating speed of 450r/min until the system is stable, keeping the temperature of the system at 25-40 ℃, keeping the temperature for 1h, heating to 50 ℃, keeping the temperature for 5h, cooling to room temperature, filtering to obtain spheres, leaching the spheres with water at 85 ℃, and drying in vacuum to obtain the colored polymer microspheres, namely the biodegradable food pigment microcapsules.
Polylactic acid attracts a great deal of researchers' attention as a controllable biodegradable polymer material because it has the following advantages: 1) the food dye has good biocompatibility and has no mutual influence with food dye molecules; 2) the biodegradable film has complete biodegradability in various environments, and the degradation rate is adjustable; 3) the polylactic acid is composed of lactic acid, has no toxicity and immunogenicity, and water and carbon dioxide formed after biodegradation can not generate toxicity to human bodies; 4) the polylactic acid is a renewable resource, has wide material source, and is cheap and good. The polylactic acid is used as a carrier of the edible pigment, so that not only is the direct contact between edible pigment molecules and human organs avoided, but also the stability of the edible pigment in the body is improved, and the pollution of the pigment to the environment is reduced.
The invention has the advantages that: the microcapsule prepared by the invention aims at reducing the toxicity of azo pigments, and the biodegradable polylactic acid material is selected as the wall material to prepare the pigment microcapsule with biodegradability, so that the possibility of the pigments contacting human organs can be reduced or avoided, the reduction and degradation of azo pigments in organ tissues and intestinal tracts can be reduced or even completely avoided, and the safety of the edible pigments is greatly improved.
Detailed Description
The first embodiment is as follows:
a preparation method of biodegradable food pigment microcapsules comprises the following steps:
(1) weighing 1g of polylactic acid and 50mL of dichloromethane, mixing, putting into a reaction vessel, starting stirring, then putting the reaction vessel into a water bath, heating to 50 ℃, and then adding 2g of polyvinylpyrrolidone and 0.75g of triton X-100 to obtain an oil phase system;
(2) weighing 8mL of methacryloyloxyethyl trimethyl ammonium chloride, 10mL of deionized water, 0.05g of potassium persulfate and 0.12g of sodium bisulfite, mixing, introducing argon for 30min, heating to 30 ℃, keeping the temperature for 5h, adding 0.5g of carmine, uniformly mixing, and putting into the reactor in the step (1); finally, stirring uniformly at the rotating speed of 400r/min to enable the water phase to form uniform liquid drops to be dispersed in the oil phase system, and obtaining a W/O internal water phase system;
(3) weighing 2.5g of polyvinyl alcohol, 800.6 g of Tween and 250mL of deionized water, mixing, and uniformly stirring at a rotating speed of 400r/min to obtain an external water phase system; adding the W/O internal aqueous phase system obtained in the step (2) into an external aqueous phase system to obtain a W/O/W reversed-phase suspension polymerization system;
(4) continuously stirring the W/O/W reversed phase suspension polymer system at the rotating speed of 450r/min until the system is stable, keeping the temperature of the system at 30 ℃ for 1h, heating to 50 ℃, keeping the temperature for 5h, cooling to 20 ℃, filtering to obtain spheres, leaching the spheres with water at 85 ℃, and drying in vacuum to obtain the colored polymer microspheres, namely the biodegradable food pigment microcapsules.
Example two:
a preparation method of biodegradable food pigment microcapsules comprises the following steps:
(1) weighing 1g of polylactic acid and 50mL of dichloromethane, mixing, putting into a reaction vessel, starting stirring, then putting the reaction vessel into a water bath, heating to 50 ℃, and then adding 2g of polyvinylpyrrolidone and 0.75g of triton X-100 to obtain an oil phase system;
(2) weighing 5mL of methacryloyloxyethyl trimethyl ammonium chloride, 10mL of deionized water, 0.06g of potassium persulfate and 0.12g of sodium bisulfite, mixing, introducing argon for 30min, heating to 30 ℃, keeping the temperature for 5h, adding 0.5g of carmine, uniformly mixing, and putting into the reactor in the step (1); finally, stirring uniformly at the rotating speed of 400r/min to enable the water phase to form uniform liquid drops to be dispersed in the oil phase system, and obtaining a W/O internal water phase system;
(3) weighing 2.5g of polyvinyl alcohol, 800.6 g of Tween and 250mL of deionized water, mixing, and uniformly stirring at a rotating speed of 400r/min to obtain an external water phase system; adding the W/O internal aqueous phase system obtained in the step (2) into an external aqueous phase system to obtain a W/O/W reversed-phase suspension polymerization system;
(4) continuously stirring the W/O/W reversed phase suspension polymer system at the rotating speed of 450r/min until the system is stable, keeping the temperature of the system at 30 ℃ for 1h, heating to 50 ℃, keeping the temperature for 5h, cooling to 20 ℃, filtering to obtain spheres, leaching the spheres with water at 85 ℃, and drying in vacuum to obtain the colored polymer microspheres, namely the biodegradable food pigment microcapsules.
Example three:
a preparation method of biodegradable food pigment microcapsules comprises the following steps:
(1) weighing 1g of polylactic acid and 50mL of dichloromethane, mixing, putting into a reaction vessel, starting stirring, then putting the reaction vessel into a water bath, heating to 50 ℃, and then adding 2g of polyvinylpyrrolidone and 0.75g of triton X-100 to obtain an oil phase system;
(2) weighing 5mL of methacryloyloxyethyl trimethyl ammonium chloride, 10mL of deionized water, 0.06g of potassium persulfate and 0.12g of sodium bisulfite, mixing, introducing argon for 30min, heating to 30 ℃, keeping the temperature for 5h, adding 0.5g of carmine, uniformly mixing, and putting into the reactor in the step (1); finally, stirring uniformly at the rotating speed of 400r/min to enable the water phase to form uniform liquid drops to be dispersed in the oil phase system, and obtaining a W/O internal water phase system;
(3) weighing 3g of polyvinyl alcohol, 800.6 g of Tween and 250mL of deionized water, mixing, and uniformly stirring at a rotating speed of 400r/min to obtain an external water phase system; adding the W/O internal aqueous phase system obtained in the step (2) into an external aqueous phase system to obtain a W/O/W reversed-phase suspension polymerization system;
(4) continuously stirring the W/O/W reversed phase suspension polymer system at the rotating speed of 450r/min until the system is stable, keeping the temperature of the system at 30 ℃ for 1h, heating to 50 ℃, keeping the temperature for 5h, cooling to 20 ℃, filtering to obtain spheres, leaching the spheres with water at 85 ℃, and drying in vacuum to obtain the colored polymer microspheres, namely the biodegradable food pigment microcapsules.
Example four:
a preparation method of biodegradable food pigment microcapsules comprises the following steps:
(1) weighing 1g of polylactic acid and 50mL of dichloromethane, mixing, putting into a reaction vessel, starting stirring, then putting the reaction vessel into a water bath, heating to 50 ℃, and then adding 2g of polyvinylpyrrolidone and 0.75g of triton X-100 to obtain an oil phase system;
(2) weighing 5mL of methacryloyloxyethyl trimethyl ammonium chloride, 10mL of deionized water, 0.06g of potassium persulfate and 0.12g of sodium bisulfite, mixing, introducing argon for 30min, heating to 30 ℃, keeping the temperature for 5h, adding 0.5g of carmine, uniformly mixing, and putting into the reactor in the step (1); finally, stirring uniformly at the rotating speed of 400r/min to enable the water phase to form uniform liquid drops to be dispersed in the oil phase system, and obtaining a W/O internal water phase system;
(3) weighing 3g of polyvinyl alcohol, 3g of Tween-800.4 g and 250mL of deionized water, and uniformly stirring at a rotating speed of 400r/min to obtain an external water phase system; adding the W/O internal aqueous phase system obtained in the step (2) into an external aqueous phase system to obtain a W/O/W reversed-phase suspension polymerization system;
(4) continuously stirring the W/O/W reversed phase suspension polymer system at the rotating speed of 450r/min until the system is stable, keeping the temperature of the system at 30 ℃ for 1h, heating to 50 ℃, keeping the temperature for 5h, cooling to 20 ℃, filtering to obtain spheres, leaching the spheres with water at 85 ℃, and drying in vacuum to obtain the colored polymer microspheres, namely the biodegradable food pigment microcapsules.
Example five:
a preparation method of biodegradable food pigment microcapsules comprises the following steps:
(1) weighing 0.8g of polylactic acid and 50mL of dichloromethane, mixing, putting into a reaction vessel, starting stirring, then putting the reaction vessel into a water bath, heating to 50 ℃, and then adding 2g of polyvinylpyrrolidone and 0.75g of triton X-100 to obtain an oil phase system;
(2) weighing 4mL of methacryloyloxyethyl trimethyl ammonium chloride, 7mL of deionized water, 0.03g of potassium persulfate and 0.06g of sodium bisulfite, mixing, introducing argon for 30min, heating to 30 ℃, keeping the temperature for 5h, adding 0.25g of carmine, uniformly mixing, and putting into the reactor in the step (1); finally, stirring uniformly at the rotating speed of 400r/min to enable the water phase to form uniform liquid drops to be dispersed in the oil phase system, and obtaining a W/O internal water phase system;
(3) weighing 2.5g of polyvinyl alcohol, 2. 800.5 g of Tween and 200mL of deionized water, mixing, and stirring uniformly at a rotating speed of 400r/min to obtain an external water phase system; adding the W/O internal aqueous phase system obtained in the step (2) into an external aqueous phase system to obtain a W/O/W reversed-phase suspension polymerization system;
(4) continuously stirring the W/O/W reversed phase suspension polymer system at the rotating speed of 450r/min until the system is stable, keeping the temperature of the system at 25 ℃ for 1h, heating to 50 ℃, keeping the temperature for 5h, cooling to 20 ℃, filtering to obtain spheres, leaching the spheres with water at 85 ℃, and drying in vacuum to obtain the colored polymer microspheres, namely the biodegradable food pigment microcapsules.
Example six:
a preparation method of biodegradable food pigment microcapsules comprises the following steps:
(1) weighing 1.5g of polylactic acid and 50mL of dichloromethane, mixing, putting into a reaction vessel, starting stirring, then putting the reaction vessel into a water bath, heating to 50 ℃, and then adding 2g of polyvinylpyrrolidone and 0.75g of triton X-100 to obtain an oil phase system;
(2) weighing 10mL of methacryloyloxyethyl trimethyl ammonium chloride, 12.5mL of deionized water, 0.075g of potassium persulfate and 0.15g of sodium bisulfite, mixing, introducing argon for 30min, heating to 30 ℃, keeping the temperature for 5h, adding 0.1g of carmine, uniformly mixing, and putting into the reactor in the step (1); finally, stirring uniformly at the rotating speed of 400r/min to enable the water phase to form uniform liquid drops to be dispersed in the oil phase system, and obtaining a W/O internal water phase system;
(3) weighing 7.5g of polyvinyl alcohol, 300mL of Tween-801.25 g of deionized water, mixing, and stirring uniformly at a rotating speed of 400r/min to obtain an external water phase system; adding the W/O internal aqueous phase system obtained in the step (2) into an external aqueous phase system to obtain a W/O/W reversed-phase suspension polymerization system;
(4) continuously stirring the W/O/W reversed phase suspension polymer system at the rotating speed of 450r/min until the system is stable, keeping the temperature of the system at 40 ℃, keeping the temperature for 1h, heating to 50 ℃, keeping the temperature for 5h, cooling to 20 ℃, filtering to obtain spheres, leaching the spheres with water at 85 ℃, and drying in vacuum to obtain the colored polymer microspheres, namely the biodegradable food pigment microcapsules.
Claims (1)
1. A preparation method of biodegradable food pigment microcapsules is characterized by comprising the following steps:
(1) weighing 0.8-1.5g of polylactic acid and 50mL of dichloromethane, mixing, putting into a reaction vessel, starting stirring, putting the reaction vessel into a water bath, heating to 50 ℃, and then adding 2g of polyvinylpyrrolidone and 0.75g of triton X-100 to obtain an oil phase system;
(2) weighing 4-10mL of methacryloyloxyethyl trimethyl ammonium chloride, 7-12.5mL of deionized water, 0.03-0.075g of potassium persulfate and 0.06-0.15g of sodium bisulfite, mixing, introducing argon for 30min, heating to 30 ℃, keeping the temperature for 5h, adding 0.25-0.1g of carmine, uniformly mixing, and putting into the reactor in the step (1); finally, stirring uniformly at the rotating speed of 400r/min to enable the water phase to form uniform liquid drops to be dispersed in the oil phase system, and obtaining a W/O internal water phase system;
(3) weighing 2.5-7.5g of polyvinyl alcohol, 1.25-1.32 g of Tween-800.5 and 300mL of deionized water, and uniformly stirring at a rotating speed of 400r/min to obtain an external water phase system; adding the W/O internal aqueous phase system obtained in the step (2) into an external aqueous phase system to obtain a W/O/W reversed-phase suspension polymerization system;
(4) continuously stirring the W/O/W reversed phase suspension polymer system at the rotating speed of 450r/min until the system is stable, keeping the temperature of the system at 25-40 ℃, keeping the temperature for 1h, heating to 50 ℃, keeping the temperature for 5h, cooling to room temperature, filtering to obtain spheres, leaching the spheres with water at 85 ℃, and drying in vacuum to obtain the colored polymer microspheres, namely the biodegradable food pigment microcapsules.
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