CN111358769A - Antimicrobial kits and articles - Google Patents

Abstract

Provided is an antimicrobial kit, comprising an antimicrobial agent and a fabric carrier. The antimicrobial agent comprises chlorhexidine gluconate, and the fabric carrier can carry 0.025 ml to 0.075 ml of the antimicrobial agent per square centimeter, so as to topically administer 0.1 to 1.25 mg of chlorhexidine gluconate per square centimeter to the skin. The fabric carrier does not carry the antimicrobial agent in advance. Also provided is an antimicrobial product, comprising a fabric carrier. The fabric carrier carries 0.025 ml to 0.075 ml of the antimicrobial agent per square centimeter, and the antimicrobial agent comprises chlorhexidine gluconate, wherein the fabric carrier is used to topically administer 0.1 to 1.25 mg of chlorhexidine gluconate per square centimeter to the skin, so as to achieve the effect of reducing skin wound infection and using the antimicrobial agent in an appropriate amount.

Description

Antimicrobial Kits & Supplies

technical field

The present invention relates to an antimicrobial kit and article, and in particular to an antimicrobial kit and article having an antimicrobial agent and a fabric carrier.

Background technique

Healthcare infections are a major issue in global disease management. Surgical site infections, in addition to increasing medical costs and length of hospital stay, increase the risk of sepsis and death in patients. A 2016 study by the Pioneer Research Initiative on Advancing Combined Care Measures to Reduce Surgical Site Infections noted that preoperative bathing measures are underperforming. A variety of microorganisms are fixed on human skin, which are the main source of infection when wounds occur on the skin surface. If the skin surface is not completely disinfected, microorganisms in the epidermal cell layer of the skin can enter the body through medical surgery, invasive medical treatment or wound treatment, causing medical infection. Therefore, improving the execution rate of preoperative bathing and strengthening preoperative skin preparation should be one of the ways to effectively reduce the infection rate of the surgical site.

In recent years, with the aging of the population, and more and more patients suffering from special diseases such as AIDS, uremia, post-traumatic sequelae, etc. requiring special care or long-term care, the infection control requirements for special care or long-term care institutions There is also growing concern about the enforcement of infection control in institutions. In particular, the elderly and patients who need long-term care are relatively weak, and the risk of "cluster infections" of skin-to-skin infectious diseases and respiratory infectious diseases in institutions is high. Controlling protective measures and the knowledge of caregivers are important.

In addition, when medical staff perform clinical medical measures, especially emergency medical measures, such as disinfecting the skin of patients in ambulances or in emergency rooms, they often directly dip cotton swabs and gauze towels into disinfectant bottles, and then apply them to the skin. Wipe and disinfect surfaces. However, it is inconvenient to operate bottles and cans in an emergency, and cross-infection is likely to occur. After the disinfection operation is completed, the remaining disinfectant may not be used again, which also results in a waste of resources.

In view of this, how to reduce the risk of infection after invasive medical treatment, strengthen clinical medical emergency measures and infection control in long-term care facilities, and at the same time use disinfectants effectively, appropriately and conveniently, the existing technology needs to be improved. .

SUMMARY OF THE INVENTION

In order to solve the problems described in the prior art, the purpose of the present disclosure is to provide an anti-microbial kit and an anti-microbial product, so as to reduce the risk of infection after invasive medical treatment and strengthen emergency clinical measures As well as infection control in long-term care facilities, and the effect of user-friendly effective and appropriate use of antimicrobials.

The present disclosure provides an antimicrobial kit comprising an antimicrobial agent and a fabric carrier. The antimicrobial agent includes chlorhexidine gluconate (CHG), the fabric carrier can carry 0.025 milliliters to 0.075 milliliters (mL/cm ² ) of the antimicrobial agent per square centimeter, for topical administration (0.1 per square centimeter of the skin) to 1.25 mg of chlorhexidine gluconate, and the fabric carrier was not preloaded with an antimicrobial agent.

In some embodiments, the antimicrobial agent is 0.1% to 10% (w/v%) by weight volume percent of chlorhexidine gluconate in water.

In some embodiments, the antimicrobial agent is packaged in a container, and the material of the container includes, but is not limited to, polyethylene (PE), polyethylene terephthalate (PET), or a combination thereof.

In some embodiments, the fabric support has a porous network structure.

In some embodiments, the fabric support has a thickness of 30 grams to 100 grams per square meter (g/m ² ). In some embodiments, the fabric support has a thickness of 95 g/m ² .

In some embodiments, the fabric carrier is square or rectangular.

In some embodiments, wherein the fabric carrier can release the loaded antimicrobial agent to the skin without residue.

In some embodiments, the material of the fabric carrier includes, but is not limited to, polyester fiber, rayon, or a combination thereof.

In some embodiments, the fabric carrier is made of 100% polyester fiber and can carry 0.045 to 0.065 milliliters (mL/cm ² ) of antimicrobial agent per square centimeter.

The present disclosure further provides an antimicrobial product comprising a fabric carrier that carries 0.025 ml to 0.075 ml of an antimicrobial agent per square centimeter, the antimicrobial agent comprising chlorhexidine gluconate. Among them, the fabric carrier is used for topical administration of 0.1 to 1.25 mg of chlorhexidine gluconate per square centimeter to the skin.

In some embodiments, the antimicrobial product is packaged in a container comprising, but not limited to, polyethylene, polyethylene terephthalate, or a combination thereof.

The present disclosure further provides an antimicrobial product comprising a plurality of fabric carriers, each fabric carrier carrying 0.025 ml to 0.075 ml of an antimicrobial agent per square centimeter, the antimicrobial agent comprising chlorhexidine gluconate. Wherein, each fabric carrier is used for topical administration of 0.1 to 1.25 mg of chlorhexidine gluconate per square centimeter to the skin.

In some embodiments, each fabric carrier carries 30 milliliters of antimicrobial agent, and the antimicrobial agent is a 2% by weight aqueous solution of chlorhexidine gluconate.

In some embodiments, the number of these fabric carriers is 8, and they are packaged in a container, and the material of the container is polyethylene.

The present disclosure further provides an antimicrobial product, comprising at least one fabric carrier, and the at least one fabric carrier carries 0.025 ml to 0.075 ml of an antimicrobial agent per square centimeter, the antimicrobial agent comprising chlorhexidine gluconate, wherein at least one The fabric carrier is used for topical administration of 0.1 to 1.25 mg of chlorhexidine gluconate per square centimeter to the skin.

In some embodiments, the at least one fabric carrier is soaked in the antimicrobial agent, so that the soaked at least one fabric carrier carries 0.025 ml to 0.075 ml of the antimicrobial agent per square centimeter.

In some embodiments, the fabric carrier is made of polyester fibers and carries 0.045 to 0.065 milliliters of antimicrobial agent per square centimeter.

In some embodiments, eight fabric carriers are included, and the eight fabric carriers are respectively used for the shoulder and neck, chest, arms to palms, front of legs, lower abdomen, lower neck to back, and back of legs Side and back waist to buttocks.

In some embodiments, eight fabric carriers are used in sequence for the shoulder and neck area, chest, arms to palms, front of legs, lower abdomen, lower neck to back, back of legs, and back waist to the buttocks.

In some embodiments, the antimicrobial device is used prior to performing invasive medical procedures.

In some embodiments, bathing is performed prior to invasive medical procedures, followed by the use of antimicrobial products.

In some embodiments, the antimicrobial device is used once daily on the day and three days preceding the invasive medical procedure.

In some embodiments, the antimicrobial device is used daily after the invasive medical treatment until healing at the site receiving the invasive medical treatment.

As mentioned above, the antimicrobial kits and antimicrobial articles of the present disclosure all include an antimicrobial agent containing chlorhexidine gluconate and a fabric carrier. The antimicrobial kit and antimicrobial product of the present disclosure are more convenient to use because the fabric carrier can wipe a larger area, and an appropriate amount of antimicrobial agent can be used while still achieving an effective amount for disinfection. In some embodiments, the antimicrobial kit or article includes eight fabric carriers for use on the shoulder and neck, chest, arms to palms, front of legs, lower abdomen, lower neck to back , the back of the legs and the back waist to the buttocks to avoid cross-contamination and implement the disinfection effect. Antimicrobial kits and supplies can reduce the risk of infection after invasive medical procedures when used on patients undergoing invasive medical procedures; To reduce the risk of infection in the facility to strengthen infection control in the facility; if used in clinical practice, it can facilitate the effective and appropriate use of antimicrobials by the user.

Description of drawings

FIG. 1 shows a schematic diagram of the fabric carrier of the present disclosure in the wiping area of the frontal skin of a human body.

FIG. 2 shows a schematic diagram of the wiping area of the skin on the back of the human body by the fabric carrier of the present disclosure.

Description of reference numerals

10 shoulder and neck

20 boobs

30 Arms to Palms

40 front legs

50 lower abdomen

60 lower neck to back

70 back of legs

After 80, from the waist to the buttocks.

Detailed ways

The above and other embodiments, features and other advantages of the present invention will be more clearly understood with reference to the description in conjunction with the accompanying drawings.

In order to make the description of the present disclosure more detailed and complete, the embodiments and specific embodiments of the present disclosure will be described below with reference to the accompanying drawings; but this is not the only form of implementing or using the specific embodiments of the present disclosure. The embodiments disclosed below can be combined or substituted with each other under beneficial circumstances, and other embodiments can also be added to one embodiment without further description or explanation.

As used herein, "comprises", "includes", "has" and similar words designate its recited features, regions, integers, steps, operations, components and/or components, but do not exclude other features, regions, Integers, steps, operations, components, components, and/or groups thereof.

As used herein, the term "container" is meant herein to include, but is not limited to, fixed shapes, non-fixed shapes such as, for example, bags, cans, bottles, or tubes.

The antimicrobial kits of various embodiments of the present invention comprise an antimicrobial agent and a fabric carrier. The antimicrobial agent comprises chlorhexidine gluconate, which can be a 0.1% to 10% (w/v) aqueous solution of chlorhexidine gluconate, preferably 1.6% to 2.4% (w/v) chlorhexidine gluconate An aqueous solution, preferably a 2% (w/v) aqueous solution of chlorhexidine gluconate.

The fabric carrier has a porous network structure, and the pores of the porous network structure can adsorb the antimicrobial agent, thereby effectively carrying and carrying the antimicrobial agent, and the antimicrobial agent carried by the fabric carrier can be completely released during use. Taking a fabric carrier with an area of 600 square centimeters as an example, it can carry 15 to 45 milliliters of antimicrobial agent, that is, each square centimeter of the fabric carrier can carry 0.025 milliliters to 0.075 milliliters of antimicrobial agents, preferably 0.045 milliliters to 0.065 milliliters, preferably 0.045 milliliters to 0.065 milliliters. 0.05 ml, 0.1 to 1.25 mg of chlorhexidine gluconate per square centimeter for topical administration to the skin. The thickness of the fabric support is 30 g/m ² to 100 g/m ² , preferably 95 g/m ² . If the chlorhexidine gluconate aqueous solution carried by the fabric carrier is less than 0.025mL/cm ² , the chlorhexidine gluconate aqueous solution released to the skin surface is not enough to achieve the effect of disinfection; 0.075mL/cm ² is the amount that the fabric carrier can carry. The upper limit of the chlorhexidine gluconate aqueous solution exceeds the upper limit, and the chlorhexidine gluconate aqueous solution will drip and increase the difficulty of operation.

In one embodiment, the size of the fabric carrier is 20×30 cm and can carry 30 milliliters of antimicrobial agent, wherein the antimicrobial agent is a 2% (w/v) aqueous solution of chlorhexidine gluconate. According to the statistics of the Ministry of Health and Welfare and the calculation formula of body surface area: body surface area (square meter) = (weight (kg) × height (cm)/3600) ^1/2 , the average body surface area from 2 years old to adults can be calculated as: 5812 square centimeters to 18641 square centimeters. If 8 pieces of fabric carrier were wiped on the whole body skin, it was calculated that each piece of fabric carrier carrying 600 mg of chlorhexidine gluconate could deliver 0.25 mg to 0.83 mg of antimicrobial agent per square centimeter of skin topically.

The fabric carrier has the property of delivering the loaded antimicrobial agent to the skin without residue. In some embodiments, the material of the fabric carrier is a non-woven fabric of 100% polyester fiber (Polyester). In some embodiments, the material of the fabric carrier can be a non-woven fabric composed of polyester fibers and rayon, for example, a non-woven fabric that is blended with 50% polyester fiber and 50% rayon. The present invention does not limit the shape of the fabric carrier, and the fabric carrier may preferably be a rectangle, including a square, a rectangle, and the like. In some embodiments, when used for wiping a large area, the fabric carrier can be designed to be a rectangle, such as 20×30 cm. The square fabric carrier is easy to curl when wiping and disinfecting a large area, which is unfavorable for wiping, while the rectangular fabric carrier is used for wiping a large area. It has the advantages that it is not easy to curl and is easy to apply force when sterilizing.

The fabric carrier of the present invention has a porous network structure and thickness, and can protect the skin from excessive physical friction damage during clinical wiping. Therefore, in a preferred embodiment, the antimicrobial agent in the antimicrobial kit is a 2% (w/v) aqueous solution of chlorhexidine gluconate, and the antimicrobial agent can maintain comfort without moisturizing skin ingredients skin touch.

The antimicrobial kit is a combined product, the fabric carrier and the antimicrobial agent are in separate compartments, and in the same or different packaging, and the fabric carrier and the antimicrobial agent are mixed at the time of use. The number of fabric supports in the antimicrobial kit can be one piece of fabric support, or multiple pieces of fabric support. The antimicrobial agent in the antimicrobial kit can be contained in the bottle body, and the bottle body can be selected from a material that will not react with chlorhexidine gluconate and cause precipitation, without affecting the technical effect of the antimicrobial agent. The aforementioned material can be, for example, polyethylene (PE), polyethylene terephthalate (PET), or a combination thereof. Wherein, the polyethylene can include high density polyethylene and low density polyethylene. In a specific embodiment, the antimicrobial kit may comprise a 2% (w/v) aqueous solution of chlorhexidine gluconate contained in a bottle body and a fabric carrier contained in a bag body. When in use, pour all the chlorhexidine gluconate aqueous solution into the bag body, so that the fabric carrier is immersed in the chlorhexidine gluconate aqueous solution, and then take it out for use after the fabric carrier supports a sufficient amount of the chlorhexidine gluconate aqueous solution.

The antimicrobial product comprises an antimicrobial agent and a fabric carrier, and is a pre-integrated product, that is, the fabric carrier is pre-loaded with the antimicrobial agent. The antimicrobial agent and the fabric carrier are the same as the antimicrobial agent and the fabric carrier of the aforementioned antimicrobial kit, which will not be repeated here.

In a specific embodiment, the manufacturing process of the antimicrobial product is to add a 20% (w/v) aqueous solution of chlorhexidine gluconate to pure water to dilute to 2% (w/v), and then dilute the 2% (w/v) ) The aqueous solution of chlorhexidine gluconate is poured into the bag body containing at least one piece of non-woven fabric, preferably 8 pieces of non-woven fabric, and the antimicrobial product is obtained after sealing. Among them, the material of the bag body is polyethylene. In addition to good sealing performance, the polyethylene bag body will not act with chlorhexidine gluconate under long-term contact with the antimicrobial agent to cause the precipitation of the antimicrobial agent, and does not affect the antimicrobial agent. effect.

In some embodiments, antimicrobial kits or antimicrobial articles may be applied to the skin prior to invasive medical procedures to reduce the risk of medical infections. Invasive medical procedures may be, for example: stab incisions, puncture, insertion of catheters or drains, and the like. Take the incision surgery as an example: after taking a full body bath three days before the operation to the night before the patient, take out the 2% (w/v) chlorhexidine gluconate aqueous solution from the anti-microbial kit or anti-microbial supplies every day. Wipe the entire body with a fully soaked fabric carrier; wipe the entire body again on the day of surgery with the Antimicrobial Kit or Antimicrobial Supplies. After invasive medical treatment, the whole body or the invasive medical treatment can also be swabbed with an antimicrobial kit or anti-microbial product until the invasive medical treatment has healed.

In one embodiment, the antimicrobial kit or the antimicrobial product can be used for cleaning and disinfecting the skin or utensils, and there is no need to wash with water after use. For example: patients in intensive care units and patients in long-term care can wipe their bodies with antimicrobial kits or antimicrobial products daily to reduce the risk of nosocomial infections; patients after invasive medical treatment can also use antimicrobial kits swabbing the whole body or affected area undergoing invasive medical treatment to reduce the risk of postoperative infection; in clinical medical care, especially in emergency situations, such as emergency use of antimicrobial kits or antimicrobials in ambulances The article is used for the disinfection of the patient's skin, and a package is provided with a combination of multiple pieces of fabric carrier impregnated with an aqueous solution of 2% (w/v) chlorhexidine gluconate, so as to achieve the effect of being convenient to use and avoiding the waste of antimicrobial agents; medical equipment For example, catheters can also be sterilized with antimicrobial kits or supplies prior to invasive medical procedures.

In one embodiment, when the antimicrobial kit or the antimicrobial product is in use, a fabric carrier loaded with an antimicrobial agent is locally applied to the skin for disinfection and sterilization, and a single fabric carrier is used in a partitioned and single-use manner to prevent cross-infection . For example: establish an eight-step clinical use sequence according to the disinfection parts required by the human body, and wipe in this sequence to avoid cross-infection. According to Figure 1 and Figure 2, the body is divided into eight areas, which are the shoulders and neck parts of the front of the human body 10, the chest 20. The arms to the palms 30, the front of the legs 40, the lower abdomen 50, the lower neck of the back of the human body to the back 60, the back of the legs 70, the back waist to the buttocks 80. Wherein, the chest 20 may also include the chest and the surrounding parts of the chest, and the back waist to the buttocks 80 includes the waist to the back side of the connection between the buttocks and the thighs. When using an anti-microbial kit or anti-microbial product, wipe the skin that needs to be cleaned and disinfected with a piece of fabric carrier carrying the antimicrobial agent in each of the above eight zones, and ensure that the skin is fully wiped with the antimicrobial agent for 30 seconds Let the skin dry naturally. After wiping with the microbial agent, the skin will appear shiny, which can be judged that the skin has been sufficiently rubbed with the antimicrobial agent. In other embodiments, the antimicrobial kit or the antimicrobial product can also be applied to the topical skin with a single single sheet of the antimicrobial agent-loaded fabric carrier during use, and is not limited to the above-mentioned usage.

As mentioned above, the antimicrobial kits and antimicrobial articles of the present disclosure all include an antimicrobial agent containing chlorhexidine gluconate and a fabric carrier. The antimicrobial kit and antimicrobial product of the present disclosure are more convenient to use because the fabric carrier can wipe a larger area, and an appropriate amount of antimicrobial agent can be used while still achieving an effective amount for disinfection. In some embodiments, the antimicrobial kit or article includes eight fabric carriers for use on the shoulder and neck, chest, arms to palms, front of legs, lower abdomen, lower neck to back , the back of the legs and the back waist to the buttocks to avoid cross-contamination and implement the disinfection effect. Antimicrobial kits and supplies can reduce the risk of infection after invasive medical procedures when used on patients undergoing invasive medical procedures; To reduce the risk of infection in the facility to strengthen infection control in the facility; if used in clinical practice, it can facilitate the effective and appropriate use of antimicrobials by the user.

Although the present invention has been disclosed in the above embodiments, it is not intended to limit the present invention. Any person skilled in the art can make various changes and modifications without departing from the spirit and scope of the present invention. The scope of protection shall be determined by the claims.

Claims (25)

1. an antimicrobial set, is characterized in that, comprises: an antimicrobial agent comprising chlorhexidine gluconate; and A fabric carrier that can carry 0.025 to 0.075 milliliters of the antimicrobial agent per square centimeter, for topical administration to the skin of 0.1 to 1.25 milligrams per square centimeter of the chlorhexidine gluconate, and the fabric carrier does not pre-carry the antimicrobial agent Microbial agents. 2. The antimicrobial kit of claim 1, wherein the antimicrobial agent is an aqueous solution of 0.1% to 10% by weight of chlorhexidine gluconate, and the antimicrobial agent is packaged in a container, The material of the container includes polyethylene, polyethylene terephthalate or a combination thereof. 3. The antimicrobial kit of claim 1, wherein the material of the fabric carrier comprises polyester fiber, rayon or a combination thereof. 4. an antimicrobial article, is characterized in that, comprises: a fabric carrier carrying 0.025 milliliters to 0.075 milliliters of antimicrobial agent per square centimeter, the antimicrobial agent comprising chlorhexidine gluconate; Wherein, the fabric carrier is used for topical administration of 0.1 to 1.25 mg of the chlorhexidine gluconate per square centimeter to the skin. 5. The antimicrobial product of claim 4, wherein the antimicrobial agent is an aqueous solution of chlorhexidine gluconate with a percentage by weight of 0.1% to 10% by volume. 6. The antimicrobial article of claim 4, wherein the fabric carrier has a porous mesh structure. 7. The antimicrobial article of claim 4, wherein the fabric carrier has a thickness of 30 grams to 100 grams per square meter. 8. The antimicrobial article of claim 7, wherein the fabric carrier has a thickness of 95 grams per square meter. 9. The antimicrobial article of claim 4, wherein the fabric carrier is square or rectangular. 10. The antimicrobial product of any one of claims 4 to 9, wherein when the fabric carrier discharges the antimicrobial agent, no antimicrobial agent remains in the fabric carrier. 11. The antimicrobial product of claim 10, wherein the material of the fabric carrier comprises polyester fiber, rayon or a combination thereof. 12 . The antimicrobial product of claim 11 , wherein the fabric carrier is made of 100% polyester fiber, and carries 0.045 to 0.065 ml of antimicrobial agent per square centimeter. 13 . 13. The antimicrobial product of claim 4, wherein the antimicrobial product is packaged in a container, and the material of the container comprises polyethylene, polyethylene terephthalate, or a combination thereof. 14. An antimicrobial product, characterized in that, comprising: a plurality of fabric carriers, each fabric carrier carrying 0.025 milliliters to 0.075 milliliters of antimicrobial agent per square centimeter, the antimicrobial agent comprising chlorhexidine gluconate; Wherein, each of the fabric carriers is used for topical administration of 0.1 to 1.25 mg of the chlorhexidine gluconate per square centimeter of the skin. 15. antimicrobial product as claimed in claim 14, wherein, the material of each this fabric carrier is 100% polyester fiber and carries the antimicrobial agent of 30 milliliters, and this antimicrobial agent is the gluconic acid chloride of 2% by weight volume Hexidine aqueous solution. 16. The antimicrobial product according to claim 14, wherein the number of the fabric carriers is 8, and is packaged in a container, and the material of the container is polyethylene. 17. An antimicrobial product, characterized in that, comprising: at least one fabric carrier, the at least one fabric carrier carrying 0.025 milliliters to 0.075 milliliters of antimicrobial agent per square centimeter, the antimicrobial agent comprising chlorhexidine gluconate; Wherein, the at least one fabric carrier is used for topical administration of 0.1 to 1.25 mg of the chlorhexidine gluconate per square centimeter to the skin. 18. antimicrobial article as claimed in claim 17, wherein, this at least one fabric carrier is soaked in this antimicrobial agent, make this at least one fabric carrier after soaking carries this antimicrobial of 0.025 milliliters to 0.075 milliliters per square centimeter agent. 19. The antimicrobial product according to claim 17 or 18, wherein the material of the fabric carrier is 100% polyester fiber, and each square centimeter carries 0.045 to 0.065 ml of the antimicrobial agent. 20. The antimicrobial product of claim 17 or 18, comprising eight fabric carriers, which are respectively used for shoulder and neck position, chest, arms to palms, front sides of legs, lower abdomen, From the lower neck to the back, the back of the legs, and the back of the waist to the buttocks. 21. The antimicrobial article of claim 17 or 18, which is used prior to performing invasive medical procedures. 22. The antimicrobial product of claim 21, wherein the antimicrobial product is used after bathing before invasive medical treatment is performed. 23. The antimicrobial product of claim 21, which is used once a day on the day and three days before the invasive medical treatment. 24. The antimicrobial product of claim 21, which is used daily after the invasive medical treatment until healing at the site receiving the invasive medical treatment. 25. antimicrobial article as claimed in claim 21, it comprises eight fabric carriers, and this eight fabric carriers are respectively used for shoulder and neck position, chest, arms to palms, front sides of legs, lower abdomen, lower Neck to back, back of legs, and waist to buttocks.

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