CN111298023A - Chilblain ointment prepared from extractive solutions of oak and pine tree, and its preparation method - Google Patents
Chilblain ointment prepared from extractive solutions of oak and pine tree, and its preparation method Download PDFInfo
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Abstract
The chilblain cream utilizing the oak tree and pine extract provided by the invention comprises the following components in parts by weight: 15-20 parts of oak extracting solution, 10-20 parts of pine extracting solution, 15-18 parts of mutton tallow, 3-8 parts of polyporus umbellatus, 6-10 parts of cactus, 6-10 parts of bletilla striata, 3-8 parts of selfheal and 50-70 parts of vaseline. By the compatibility and extraction of the raw materials, the effective components of the composition are exerted to the greatest extent, so that the perniosis cream utilizing the extracting solution of the oak and the pine has enhanced permeability, can effectively permeate into a focus, and has good prevention and treatment effects; can rapidly eliminate red swelling and make skin delicate. The chilblain cream utilizing the oak extract and the pine extract disclosed by the invention contains fewer compatible traditional Chinese medicines, can be extracted according to the characteristics of each raw material, can effectively separate the effective components of each component, and can play a better drug effect after the effective components of each component are combined, so that the prevention and treatment effects are optimal.
Description
Technical Field
The invention belongs to the field of medicines, and particularly relates to chilblain cream prepared from oak and pine extract and a preparation method thereof.
Background
Chilblain is a peripheral circulation disorder disease, is a seasonal lesion which is easy to occur in cold seasons, belongs to non-freezing frostbite, frequently occurs in women, children and old people unconsciously and well, is mostly positioned at fingers, backs of hands, heels, foot margins, cheeks, ears, nasal tips and the like, causes diseases in winter every year, self-heals after warming, prolongs the course of diseases and is easy to relapse in the next year. The pathological research shows that the chilblain is caused by the blood vessel function loss, microcirculation disturbance and ischemia and anoxia of local tissues due to cold stimulation and air humidity simultaneously acting on the peripheral parts of the body. The theory of the traditional Chinese medicine considers that cold invasion in winter causes unsmooth circulation of qi and blood, obstruction of channels and collaterals and stagnation of qi and blood in skin to form the chilblain, so that the chilblain is prevented and treated by taking channel warming, cold dispelling, blood circulation promoting, blood stasis removing, swelling eliminating and pain relieving as treatment criteria, and sore astringing and tissue regeneration promoting medicines are required to be added for treating chilblain surface ulceration, and the chilblain surface ulceration is treated by externally coating medicines.
Common chilblain ointment using the extract of oak and pine tree is not lack of some irritative medicines such as camphor, which can cause allergic dermatitis when being used externally, and is volatile and brings side effects when being used with caution by skin allergy patients; moreover, the chilblain ointment only treats the symptoms, but cannot eradicate the chilblain, and the chilblain ointment which is safe to apply and good in effect and utilizes the extract of the oak and the pine is urgently needed in the market.
Disclosure of Invention
The chilblain cream utilizes the extract of the oak and the pine to solve the problems, and is prepared from the extract of the oak, the extract of the pine, the mutton tallow, the umbellate pore fungus, the cactus, the bletilla striata, the selfheal and the vaseline. By the compatibility and extraction of the raw materials, the effective components of the composition are exerted to the greatest extent, so that the perniosis cream utilizing the extracting solution of the oak and the pine has enhanced permeability, can effectively permeate into a focus, and has good prevention and treatment effects; can rapidly eliminate red swelling and make skin delicate. The chilblain cream utilizing the oak tree and pine extract disclosed by the invention is pure natural in raw materials, free of toxic and side effects, safer and safe to use.
The invention is realized by the following technical scheme:
the chilblain cream utilizing the extract of the oak and the pine comprises the following components in parts by weight: 15-20 parts of oak extracting solution, 10-20 parts of pine extracting solution, 15-18 parts of mutton tallow, 3-8 parts of polyporus umbellatus, 6-10 parts of cactus, 6-10 parts of bletilla striata, 3-8 parts of selfheal and 50-70 parts of vaseline.
The preparation method of the chilblain cream by using the extract of the oak and the pine comprises the following steps:
s1, preparing an oak extracting solution: heating plant fragments of the oak to be carbonized, condensing and recovering discharged gas, standing for 2-3 months, distilling the middle layer liquid, taking distillate of distillate at 105-110 ℃, and filtering by using filter paper to obtain an oak extracting solution;
s2, preparing a pine tree extracting solution: pulverizing pine tree branches, degreasing with petroleum ether, adding into water, soaking, microwave extracting and ultrasonic oscillating extracting, and filtering to obtain fiber residue; decolorizing the filtrate, concentrating to obtain pine tree extract, standing for layering, and collecting the intermediate clear solution to obtain pine tree extract;
s3, cleaning, drying and grinding the polyporus umbellatus, the cactus, the bletilla striata and the selfheal into powder, adding distilled water, performing ultrasonic treatment at 48-52 ℃, and performing distillation treatment to recover a primary extracting solution; performing carbon dioxide supercritical extraction on the primary extracting solution, and filtering to obtain a traditional Chinese medicine extracting solution;
s4, extracting the liquid obtained from the traditional Chinese medicine filtrate for multiple times by using ether, collecting ether extract, adding anhydrous sodium sulfate, drying, and recovering ether in a water bath at 45-60 ℃ to obtain a traditional Chinese medicine concentrated solution;
s5, heating and melting vaseline and mutton tallow, uniformly mixing, cooling to 60-80 ℃,
s6, adding the oak extract, the pine extract and the traditional Chinese medicine concentrated solution into the mixture obtained in the step S5 to obtain the tea.
Further, the distillate obtained in the step S1 is adsorbed by activated carbon for 4-6 hours, and is filtered by filter paper for 3-6 times. Further, the microwave extraction conditions in step S2 are as follows: microwave extraction is carried out for 5min to 10min at the power of 100W to 200W; the ultrasonic oscillation extraction conditions are as follows: the ultrasonic frequency is 40-60 kHz, the power is 80-110W, and the ultrasonic oscillation extraction is performed for 20-30 min.
Further, the mass ratio of the total mass of the grifola, the cactus, the bletilla striata and the selfheal to the distilled water in the step S3 is 1: 10-15.
Further, in the step S3, the extraction pressure of the carbon dioxide supercritical extraction is 20-40 MPa, the temperature is 60-80 ℃, and CO is used for CO extraction2The flow rate is 2-5L/h, and the extraction time is 100-120 min.
Further, in the step S3, the frequency of the ultrasonic treatment is 40-60 KHz, the power is 400-600W, and the treatment time is 5-10 min.
The pine tree extract of the invention can prolong the efficacy of vitamin C in human body, activate the action of vitamin C and vitamin E, inhibit nucleic acid damage caused by lipoprotein oxidation and hydroxyl free radical, activate the secretion of growth hormone of human body, improve immune response and protect nerve cells from being damaged by glutamate salt, fat or anion form thereof, can delay the decline of immunity and the decline of metabolism function of blood cells in the aging process, and can restore the normal level of the immunity and the fat and the metabolism function of the blood cells. The pine extract can increase hormone secretion, delay cell aging, and promote cell regeneration.
The oak extract has certain curative effect on treating human epidermal inflammatory, infectious or suppurative diseases caused by staphylococcus aureus or pseudomonas aeruginosa.
Compared with the prior art, the chilblain cream utilizing the oak and pine extracting solution has the following advantages:
the chilblain cream utilizing the oak and pine extracting solution uses the oak extracting solution, the pine extracting solution, the mutton tallow, the polyporus umbellatus, the cactus, the bletilla striata, the selfheal and the vaseline as raw materials, and the active ingredients of the composition are exerted to the greatest extent through the compatibility and the extraction of the raw materials, so that the chilblain cream utilizing the oak and pine extracting solution has enhanced permeability, can effectively permeate into a focus, and has good prevention and treatment effects; can rapidly eliminate red swelling and make skin delicate. The chilblain cream utilizing the oak tree and pine extract disclosed by the invention is pure natural in raw materials, free of toxic and side effects, safer and safe to use.
The chilblain cream utilizing the oak extract and the pine extract disclosed by the invention contains fewer compatible traditional Chinese medicines, can be extracted according to the characteristics of each raw material, can effectively separate the effective components of each component, and can play a better drug effect after the effective components of each component are combined, so that the prevention and treatment effects are optimal. The chilblain ointment has low cost and obvious curative effect.
The traditional Chinese medicine composition of the chilblain cream utilizing the oak and pine extracting solution disclosed by the invention is simple in process and preparation process, does not generate any harmful substance to the environment in the reaction process, is convenient to operate, and is low in energy consumption and less in pollution.
Detailed Description
The invention is further illustrated by the following specific examples. The starting materials and the methods employed in the examples of the present invention are those conventionally available in the art and those conventionally used, and the equipment used is equipment conventional in the art, unless otherwise specified.
The chilblain cream utilizing the oak tree and pine extract provided by the invention comprises the following components in parts by weight: 15-20 parts of oak extracting solution, 10-20 parts of pine extracting solution, 15-18 parts of mutton tallow, 3-8 parts of grifola, 6-10 parts of cactus, 3-9 parts of pine leaves, 6-10 parts of bletilla striata, 3-8 parts of selfheal and 50-70 parts of vaseline.
Example 1
The chilblain cream utilizing the extract of the oak and the pine provided by the embodiment comprises the following components in parts by weight: 15 parts of oak extracting solution, 20 parts of pine extracting solution, 15 parts of mutton tallow, 8 parts of polyporus umbellatus, 10 parts of cactus, 10 parts of bletilla striata, 3 parts of selfheal and 70 parts of vaseline.
The preparation method comprises the following steps:
s1, preparing an oak extracting solution: heating plant fragments of the oak to be carbonized, condensing and recovering discharged gas, standing for 2-3 months, distilling the middle layer liquid, absorbing distillate of distillate at 105-110 ℃ for 4-6 hours by using activated carbon, and filtering for 3-6 times by using filter paper to obtain an oak extracting solution;
s2, preparing a pine tree extracting solution: pulverizing pine tree branches, degreasing with petroleum ether, adding into water, soaking, microwave extracting and ultrasonic oscillating extracting, and filtering to obtain fiber residue; decolorizing the filtrate, concentrating to obtain pine tree extract, standing for layering, and collecting the intermediate clear solution to obtain pine tree extract; wherein, the microwave extraction conditions are as follows: microwave extracting at power of 100W for 10 min; the ultrasonic oscillation extraction conditions are as follows: ultrasonic frequency of 40kHz, power of 80W, and ultrasonic vibration extraction for 20 min.
S3, cleaning the grifola, the cactus, the bletilla striata and the selfheal, drying, grinding into powder, and adding distilled water, wherein the mass ratio of the total mass of the grifola, the cactus, the bletilla striata and the selfheal to the distilled water is 1: 15; carrying out ultrasonic treatment at 48-52 ℃, and then distilling to recover a primary extracting solution; performing carbon dioxide supercritical extraction on the primary extracting solution, and filtering to obtain a traditional Chinese medicine extracting solution; wherein the extraction pressure of the carbon dioxide supercritical extraction is 20MPa, the temperature is 80 ℃, and CO is adopted2The flow rate is 2L/h, and the extraction time is 120 min; the ultrasonic treatment frequency is 40KHz, the power is 400W, and the treatment time is 10 min.
S4, extracting the liquid obtained from the traditional Chinese medicine filtrate for multiple times by using ether, collecting ether extract, adding anhydrous sodium sulfate, drying, and recovering ether in a water bath at 45-60 ℃ to obtain a traditional Chinese medicine concentrated solution;
s5, heating and melting vaseline and mutton tallow, uniformly mixing, cooling to 60-80 ℃,
s6, adding the oak extract, the pine extract and the traditional Chinese medicine concentrated solution into the mixture obtained in the step S5 to obtain the tea.
Example 2
The chilblain cream utilizing the extract of the oak and the pine provided by the embodiment comprises the following components in parts by weight: 20 parts of oak extracting solution, 12 parts of pine extracting solution, 15 parts of mutton tallow, 4 parts of polyporus umbellatus, 6 parts of cactus, 6 parts of bletilla striata, 8 parts of selfheal and 60 parts of vaseline.
The preparation method comprises the following steps:
s1, preparing an oak extracting solution: heating plant fragments of the oak to be carbonized, condensing and recovering discharged gas, standing for 2-3 months, distilling the middle layer liquid, absorbing distillate of distillate at 105-110 ℃ for 4-6 hours by using activated carbon, and filtering for 3-6 times by using filter paper to obtain an oak extracting solution;
s2, preparing a pine tree extracting solution: pulverizing pine tree branches, degreasing with petroleum ether, adding into water, soaking, microwave extracting and ultrasonic oscillating extracting, and filtering to obtain fiber residue; decolorizing the filtrate, concentrating to obtain pine tree extract, standing for layering, and collecting the intermediate clear solution to obtain pine tree extract; wherein, the microwave extraction conditions are as follows: microwave extracting at power of 180W for 5 min; the ultrasonic oscillation extraction conditions are as follows: ultrasonic frequency of 60kHz, power of 80W, and ultrasonic vibration extraction for 30 min.
S3, cleaning the grifola, the cactus, the bletilla striata and the selfheal, drying, grinding into powder, and adding distilled water, wherein the mass ratio of the total mass of the grifola, the cactus, the bletilla striata and the selfheal to the distilled water is 1: 10; carrying out ultrasonic treatment at 48-52 ℃, and then distilling to recover a primary extracting solution; performing carbon dioxide supercritical extraction on the primary extracting solution, and filtering to obtain a traditional Chinese medicine extracting solution; wherein the extraction pressure of the supercritical carbon dioxide extraction is 30MPa, the temperature is 60 ℃, and CO is adopted2The flow rate is 5L/h, and the extraction time is 100 min; the ultrasonic treatment frequency is 60KHz, the power is 500W, and the treatment time is 6 min.
S4, extracting the liquid obtained from the traditional Chinese medicine filtrate for multiple times by using ether, collecting ether extract, adding anhydrous sodium sulfate, drying, and recovering ether in a water bath at 45-60 ℃ to obtain a traditional Chinese medicine concentrated solution;
s5, heating and melting vaseline and mutton tallow, uniformly mixing, cooling to 60-80 ℃,
s6, adding the oak extract, the pine extract and the traditional Chinese medicine concentrated solution into the mixture obtained in the step S5 to obtain the tea.
Example 3
The chilblain cream utilizing the extract of the oak and the pine provided by the embodiment comprises the following components in parts by weight: 16 parts of oak extracting solution, 15 parts of pine extracting solution, 15 parts of mutton tallow, 6 parts of polyporus umbellatus, 8 parts of cactus, 9 parts of bletilla striata, 3 parts of selfheal and 50 parts of vaseline.
The specific preparation method is basically the same as that of example 1.
Comparative example 1
The chilblain cream utilizing the oak tree and pine extract provided by the comparative example comprises the following components in parts by weight: 15 parts of pine extract, 15 parts of mutton tallow, 6 parts of grifola, 8 parts of cactus, 9 parts of bletilla striata, 3 parts of selfheal and 50 parts of vaseline. That is, the procedure of example 1 was repeated except that the oak extract was not added to the raw material and the operation of step S1 was omitted.
Comparative example 2
The chilblain cream prepared from the extract of the oak and the pine provided by the comparative example comprises the following raw materials in parts by weight: 16 parts of oak extracting solution, 15 parts of mutton tallow, 6 parts of polyporus umbellatus, 8 parts of cactus, 9 parts of bletilla striata, 3 parts of selfheal and 50 parts of vaseline. That is, the procedure of example 1 was repeated except that the pine extract was not added to the raw material and the operation of step S2 was omitted in the specific operation.
Comparative example 3
The chilblain cream utilizing the extract of the oak and the pine provided by the embodiment comprises the following components in parts by weight: 15 parts of oak extracting solution, 20 parts of pine extracting solution, 15 parts of mutton tallow, 8 parts of polyporus umbellatus, 10 parts of cactus, 10 parts of bletilla striata, 3 parts of selfheal and 70 parts of vaseline. Pulverizing oak and pine, ultrasonic treating with Polyporus, radix et caulis Opuntiae Dillenii, rhizoma Bletillae, and Prunellae Spica of step S3, distilling, recovering to obtain concentrated solution, and adding into vaseline and adeps Caprae Seu Ovis.
Firstly, animal experiments:
selecting 24 healthy mice, randomly dividing the mice into 3 groups, wherein each group comprises 8 mice, adopting a homomorphic left-right self-contrast method, shaving off hairs on two sides of the back vertebra of the mice by using an electric shaver, shaving off hairs with the area of 2cmx2cm, respectively taking 2g of chilblain cream prepared by utilizing oak and pine extracting solution in the embodiment 1-3 of the invention, smearing the chilblain cream on the skin with hair removed on the left side of the back of the mice in 1-3 groups, taking the right side as a self blank control without treatment, observing whether the skin periphery of the mice in 3 groups has allergy phenomena such as red swelling and the like every hour, washing away the cream by warm water after 24 hours, and observing the result.
Through observation, 3 groups of mice have no poisoning expression, the skin of the tested part has no allergic phenomena such as erythema, edema and the like, and the skin appearance, the color and the like are consistent with those of the right control group, which shows that the chilblain cream using the extract of the oak and the pine tree has no irritation and toxicity to the skin of the mice and does not generate the allergic phenomenon.
Second, clinical trial
1. Clinical data: the chilblain ointment prepared by the extracts of oak and pine trees in examples 1-3 and comparative examples 1-3 was applied to the affected part once a day in the morning and evening, 10 days as a treatment course, and the treatment effects are as follows:
and (3) judging the curative effect:
and (3) curing: the red and swollen part is completely eliminated;
the method has the following advantages: partial elimination of redness, reduction in range or number;
and (4) invalidation: the red and swollen part is not eliminated.
2. The therapeutic effects are shown in Table 1
TABLE 1
While the invention has been described in terms of specific process equipment and process steps, it will be understood by those skilled in the art that the invention is not limited to the embodiments described above, which are included to illustrate the principles of the invention, and that various changes and modifications, which will be apparent to those skilled in the art, may be made without departing from the spirit and scope of the invention and, therefore, the invention is to be limited only by the appended claims.
Claims (7)
1. The chilblain cream utilizing the extract of the oak and the pine is characterized by comprising the following components in parts by weight: 15-20 parts of oak extracting solution, 10-20 parts of pine extracting solution, 15-18 parts of mutton tallow, 3-8 parts of polyporus umbellatus, 6-10 parts of cactus, 6-10 parts of bletilla striata, 3-8 parts of selfheal and 50-70 parts of vaseline.
2. The method for preparing chilblain cream using oak tree and pine extract as claimed in claim 1, comprising the steps of:
s1, preparing an oak extracting solution: heating plant fragments of the oak to be carbonized, condensing and recovering discharged gas, standing for 2-3 months, distilling the middle layer liquid, taking distillate of distillate at 105-110 ℃, and filtering by using filter paper to obtain an oak extracting solution;
s2, preparing a pine tree extracting solution: pulverizing pine tree branches, degreasing with petroleum ether, adding into water, soaking, microwave extracting and ultrasonic oscillating extracting, and filtering to obtain fiber residue; decolorizing the filtrate, concentrating to obtain pine tree extract, standing for layering, and collecting the intermediate clear solution to obtain pine tree extract;
s3, cleaning, drying and grinding the polyporus umbellatus, the cactus, the bletilla striata and the selfheal into powder, adding distilled water, performing ultrasonic treatment at 48-52 ℃, and performing distillation treatment to recover a primary extracting solution; performing carbon dioxide supercritical extraction on the primary extracting solution, and filtering to obtain a traditional Chinese medicine extracting solution;
s4, extracting the liquid obtained from the traditional Chinese medicine filtrate for multiple times by using ether, collecting ether extract, adding anhydrous sodium sulfate, drying, and recovering ether in a water bath at 45-60 ℃ to obtain a traditional Chinese medicine concentrated solution;
s5, heating and melting vaseline and mutton tallow, uniformly mixing, cooling to 60-80 ℃,
s6, adding the oak extract, the pine extract and the traditional Chinese medicine concentrated solution into the mixture obtained in the step S5 to obtain the tea.
3. The method for preparing a chilblain cream using oak tree and pine extract as claimed in claim 2, wherein the distillate of step S1 is adsorbed by activated carbon for 4-6 hours and filtered by filter paper for 3-6 times.
4. The method for preparing chilblain cream using oak tree and pine extract of claim 2, wherein the microwave extraction conditions of step S2 are as follows: microwave extraction is carried out for 5min to 10min at the power of 100W to 200W; the ultrasonic oscillation extraction conditions are as follows: the ultrasonic frequency is 40-60 kHz, the power is 80-110W, and the ultrasonic oscillation extraction is performed for 20-30 min.
5. The method for preparing a chilblain cream using oak and pine extract as claimed in claim 2, wherein the mass ratio of the total mass of polyporus umbellatus, cactus, bletilla striata and prunella vulgaris in step S3 to distilled water is 1: 10-15.
6. The method for preparing chilblain cream using oak tree and pine extract as claimed in claim 2, wherein the supercritical carbon dioxide extraction in step S3 is carried out at 60-80 deg.C under 20-40 MPa CO2The flow rate is 2-5L/h, and the extraction time is 100-120 min.
7. The method for preparing chilblain cream using oak tree and pine extract according to claim 2, wherein the ultrasonic treatment in step S3 is performed at a frequency of 40 to 60KHz and a power of 400 to 600W for 5 to 10 min.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1078394A (en) * | 1993-02-18 | 1993-11-17 | 冯家兴 | Quick-acting chilblain ointment |
| CN1385168A (en) * | 2002-05-31 | 2002-12-18 | 成进学 | External used functional medicine whose Chinese medicine prescription intensified by snake macro-micro element |
| CN1761450A (en) * | 2003-02-13 | 2006-04-19 | 株式会社林原生物化学研究所 | External preparation for skin characterized by containing saccharide derivative of α,α-trehalose |
| CN101822707A (en) * | 2009-03-04 | 2010-09-08 | 曾新华 | Medicament for beautifying skin and treating scald and burn and preparation method thereof |
| CN107802813A (en) * | 2017-12-04 | 2018-03-16 | 成都迅达物成生物科技有限公司 | The pharmaceutical composition of anti-frostbite |
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2018
- 2018-12-12 CN CN201811514905.5A patent/CN111298023A/en active Pending
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| CN1078394A (en) * | 1993-02-18 | 1993-11-17 | 冯家兴 | Quick-acting chilblain ointment |
| CN1385168A (en) * | 2002-05-31 | 2002-12-18 | 成进学 | External used functional medicine whose Chinese medicine prescription intensified by snake macro-micro element |
| CN1761450A (en) * | 2003-02-13 | 2006-04-19 | 株式会社林原生物化学研究所 | External preparation for skin characterized by containing saccharide derivative of α,α-trehalose |
| CN101822707A (en) * | 2009-03-04 | 2010-09-08 | 曾新华 | Medicament for beautifying skin and treating scald and burn and preparation method thereof |
| CN107802813A (en) * | 2017-12-04 | 2018-03-16 | 成都迅达物成生物科技有限公司 | The pharmaceutical composition of anti-frostbite |
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