CN111281811A

CN111281811A - Washing-free disinfecting skin-care cream and preparation method thereof

Info

Publication number: CN111281811A
Application number: CN202010201774.6A
Authority: CN
Inventors: 卞春亮; 张青; 曹军; 曹家瑞
Original assignee: Komi Limei Biotechnology Co ltd
Current assignee: Komi Limei Biotechnology Co ltd
Priority date: 2020-03-20
Filing date: 2020-03-20
Publication date: 2020-06-16

Abstract

The invention discloses a washing-free disinfecting skin cream, which consists of 60 to 75 parts of ethanol, 0.1 to 0.2 part of bactericide, 2 to 10 parts of humectant, 0.7 to 1.5 parts of thickening agent, 3 to 10 parts of grease, 2 to 5 parts of emollient, 20 to 30 parts of deionized water, 0.2 to 0.5 part of neutralizer, 0.1 to 0.5 part of essence and 1.0 to 2.0 parts of emulsifier; the alcohol disinfectant has the advantages of stable property, good sterilization effect, long antibacterial time, no irritation, convenient and safe use, good skin care effect, capability of reducing ignition point of the alcohol disinfectant, improvement on safety of the alcohol disinfectant, effect of protecting skin of users by moisture-preserving components, oil and emollient, simple process and low production cost.

Description

Washing-free disinfecting skin-care cream and preparation method thereof

Technical Field

The invention belongs to the technical field of disinfectants, and particularly relates to a washing-free disinfecting skin-care cream and a preparation method thereof.

Background

Various microorganisms exist in nature, and some microorganisms can cause harm to human bodies and the environment under certain conditions. In daily life, people always come into contact with various bacteria and viruses, especially in crowded places with many people, such as buses, subways, entertainment places and the like. These pathogens pose a great threat to our health and well-being. Diseases caused by infection with pathogenic microorganisms remain one of the major threats facing human survival, and there is often a new discovery of pathogens, so disinfection remains the most basic and effective means. Disinfection refers to a method for killing pathogenic microorganisms, and medicines for disinfection are collectively called disinfectant. As the living standard of people is improved, the consciousness of personal hygiene and personal protection is enhanced, the requirements on disinfection products are higher and higher, the disinfection is required to be rapid, safe and free from toxic and side effects, the disinfection products contacting with the skin are required to have the skin care effect, along with the development of society and economy, the living rhythm of people is accelerated, the sexual requirements on daily convenient use products are higher and higher, the demand is also increased, and the disinfectant in the form of cream is a popular personal hygiene disinfection product due to the characteristic of convenient use.

At present, skin disinfectants in the market are various, and common skin disinfectants mainly comprise ethanol, iodine, biguanide antibacterial agents, quaternary ammonium salt compounds, triclosan and the like. Iodine and iodine-containing preparations are widely used skin disinfectants in clinical practice. The iodine-containing preparation commonly used in clinic is mainly iodine, iodine water and povidone iodine. Povidone iodine is currently the most predominant iodine-containing skin disinfectant, and is an amorphous complex of iodine in combination with a surfactant. But the color and cost of iodine preparations limits their use in everyday life.

The biguanide antibacterial agent has quite strong broad-spectrum antibacterial and bactericidal effects and has effects on various bacteria, and the external antibacterial agent and the cationic surfactant have killing effects on a plurality of gram-positive bacteria and gram-negative bacteria. Besides bacteriostasis, the bactericide can also kill bacteria. The principle of chlorhexidine sterilization is mainly to destroy the permeability barrier on the cytoplasmic membrane of bacteria rather than the previous hypothesis that the enzyme loses activity to achieve the sterilization effect, a low concentration can cause partial cytoplasmic leakage, and a high concentration can cause cytoplasmic condensation denaturation, thereby sterilizing. Its advantages are less irritation and less allergic reaction. Chlorhexidine has low toxicity, small irritation and no corrosiveness, is suitable for disinfection treatment of skin mucosa and wound surface, and can be widely used for disinfection of mucosa, skin, operation, wound surface, instrument, appliance, etc. The biguanide antibacterial agent has good gram-positive bacteria resistance, weak gram-negative bacteria and fungi resistance, small effect on mycobacteria and no effect on spores. In vitro tests have shown efficacy against membrane-borne viruses such as herpes viruses, cytomegaloviruses, influenza viruses, but clearly less effective against membrane-free viruses such as rotaviruses, enteroviruses and adenoviruses.

More than 60% of ethanol can kill 99.9% of bacteria, and 70-75 parts of ethanol can thoroughly sterilize and kill virus and bacteria. Ethanol with too high concentration can form a protective film on the surface of bacteria to prevent the bacteria from entering the body of the bacteria, so that the bacteria are difficult to kill completely. If the concentration of ethanol is too low, the ethanol can enter the bacteria, but can not coagulate the protein in the body, and can not kill the bacteria completely.

The ethanol disinfectant has obvious use defects, low safety and improper use to cause fire. The hands are easy to crack, rough and peel after long-term use. The ethanol is easy to volatilize, and the action time period is short.

Disclosure of Invention

The invention aims to solve the technical problem of providing a no-clean disinfection skin-care cream and a preparation method thereof, overcoming the defects of the existing control method, and realizing the following purposes after adopting the control method of the invention:

1. can effectively reduce the volatility of the ethanol and achieve the effect of continuous disinfection.

2. Can reduce ignition point of ethanol disinfectant and improve safety of ethanol disinfectant.

3. The skin care product is added with moisture-keeping components, oil and fat and emollient, and has skin protection effect for users.

4. The bactericide compounded with cymene achieves more spectral bactericidal performance.

In order to solve the technical problems, the technical scheme of the invention is as follows: the no-clean disinfection skin-care cream is characterized by comprising the following components in parts by weight:

60-75 parts of ethanol, 0.1-0.2 part of bactericide, 2-10 parts of humectant, 0.7-1.5 parts of thickener, 3-10 parts of grease, 2-5 parts of emollient, 20-30 parts of deionized water, 0.2-0.5 part of neutralizer, 0.1-0.5 part of essence and 1.0-2.0 parts of emulsifier.

In an optimized scheme, the bactericide is cymene or chlorhexidine acetate.

In an optimized scheme, the humectant is glycerol, propylene glycol, polyethylene glycol and hyaluronic acid.

In an optimized scheme, the thickening agent is carbomer, hydroxyethyl cellulose and xanthan gum.

In an optimized scheme, the grease is cetostearyl alcohol, behenyl alcohol and stearyl alcohol.

In an optimized scheme, the emollient is polydimethylsiloxane, dioctyl carbonate, cyclomethicone and dimethiconol.

In an optimized scheme, the neutralizing agent is monoethanolamine, aminomethyl propanol, sodium hydroxide, citric acid and lactic acid.

In an optimized scheme, the emulsifier is ceteareth, steareth or cetearyl glucoside.

A preparation method of a washing-free disinfecting skin-care cream comprises the following steps:

(1) preparation of an oil phase system: mixing liquid oil, emulsifier and emollient, and heating in water bath to 70 deg.C to obtain oil phase system;

(2) preparation of an aqueous phase system: mixing deionized water, 10% of ethanol and humectant to form a water phase, dispersing a thickener into the water phase, and heating to 60 deg.C to obtain a water phase system;

(3) preparing a water phase and oil phase mixed system: stirring the water phase system obtained in the step (2) at a rotating speed of 3000r/min, adding the oil phase system obtained in the step (1), and stirring at a rotating speed of 3000r/min for 2 min;

(4) naturally cooling the mixed system obtained in step (3) to below 40 deg.C, adding essence and the dispersion obtained by mixing with bactericide (cymene) and ethanol (10% of the total amount of ethanol), stirring at rotation speed of 200r/min for 10min

(5) Adding neutralizer, adjusting pH to 3-5, adding the rest ethanol (80% ethanol), and naturally cooling to room temperature to obtain the final product.

By adopting the technical scheme, compared with the prior art, the invention has the following advantages: firstly, the washing-free disinfecting skin-care cream contains the compound of ethanol and a bactericide, and the ethanol can kill intestinal tract pathogenic bacilli, pyococcus and candida albicans. Is suitable for disinfecting hands and various skins of human bodies and the surfaces of common objects. The cymene o-cymene-5-alcohol is a very safe broad-spectrum high-efficiency antifungal bactericide which can contact mucosa, obviously inhibits and kills bacteria, saccharomycetes and molds, inhibits and kills proliferation of acne bacillus, Salmonella typhi, staphylococcus aureus, escherichia coli, serratia and carbon maggot bacteria, is safe and nontoxic, and can be used for products such as skin, oral cavity and the like.

Cymene has been shown to have excellent efficacy in a variety of skin care applications and to inhibit oxidation of the product. It is widely used in cosmetics and beauty products to prevent the propagation of harmful microorganisms, thereby extending the shelf life of the products.

The two are compounded to improve the bactericidal spectrum, and the cymene is safe and effective with low dose.

Secondly, the washing-free disinfection skin-care cream reduces the volatility of ethanol, and has the advantages of stable property, good sterilization effect, long antibacterial time, no irritation, convenient and safe use and good skin-care effect.

Thirdly, the washing-free disinfection skin-care cream can reduce the ignition point of the ethanol disinfectant and improve the safety of the ethanol disinfectant.

Fourthly, the washing-free disinfection skin-care cream is added with moisturizing components, grease and emollient, and has the effect of protecting the skin of users. Is a product introducing a skin care concept of the first disinfectant, and is also a new product introducing disinfection and sterilization in the field of skin care.

Fifthly, the preparation of the washing-free disinfecting skin-care cream has the characteristics of simple process and low production cost.

Drawings

FIG. 1 is a chart showing the skin care cream with no-clean disinfection and moisture retention test with 62% ethanol according to example 1 of the present invention;

FIG. 2 is a comparison of the moisturizing water content increase of the leave-on disinfecting skin cream of example 1 of the present invention with a 62% ethanol control;

FIG. 3 is a chart showing the skin care cream with no-clean disinfection and moisture retention test with 65% ethanol according to example 2 of the present invention;

FIG. 4 is a graph comparing the increase in moisture content of the leave-on disinfecting skin cream of example 2 of the present invention with a control of 65% ethanol;

FIG. 5 is a chart showing the leave-on disinfecting skin cream and 70% ethanol moisturizing test of example 3 of the present invention;

FIG. 6 is a graph showing the increase in moisturizing moisture content of the leave-on disinfecting skin cream of example 3 of the present invention compared with a 70% ethanol control.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be described in further detail with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

Embodiment 1, a washing-free disinfecting skin-care cream, which comprises the following raw materials in parts by weight:

62 parts of ethanol, 1 part of cetearyl alcohol, 0.1 part of cymene, 0.5 part of glycerol, 2.0 parts of propylene glycol, 2.5 parts of polydimethylsiloxane, 0.2 part of carbomer, 0.2 part of monoethanolamine, 1.0 part of cetearyl glucoside, 0.5 part of hydroxyethyl cellulose, 0.2 part of hyaluronic acid, 3 parts of dioctyl carbonate and 29.5 parts of deionized water.

The method comprises the following steps:

(1) preparation of an oil phase system: mixing the liquid oil, the emulsifier and the emollient, and heating to 70 ℃ to obtain an oil phase system;

(2) preparation of an aqueous phase system: dispersing the thickening agent into the mixture, and heating the mixture to 60 ℃ to obtain a water phase system;

(3) formation of a water-phase and oil-phase mixed system: stirring the water phase system obtained in the step (2) at a rotating speed of 3000r/min, adding the oil phase system obtained in the step (1), and stirring at a rotating speed of 3000r/min for 2 min;

(4) naturally cooling the mixed system obtained in the step (3) to below 40 ℃, adding essence, bactericide (cymene) and ethanol (10% of the total amount of ethanol) to obtain a dispersion, and stirring at the rotation speed of 200r/min for 10 min;

Embodiment 2, a washing-free disinfecting skin-care cream, which comprises the following raw materials in parts by weight:

65 parts of ethanol, 1 part of cetearyl alcohol, 0.1 part of cymene, 3.5 parts of glycerol, 2.0 parts of propylene glycol, 2.0 parts of polydimethylsiloxane, 0.2 part of xanthan gum, 0.1 part of citric acid, 1.0 part of cetearyl glucoside, 1 part of hydroxyethyl cellulose, 0.2 part of hyaluronic acid, 3 parts of dioctyl carbonate and 23.5 parts of deionized water.

The method comprises the following steps:

(2) preparation of an aqueous phase system: dispersing the thickener into a water phase formed by mixing the deionized water, the 10% ethanol and the humectant, and heating to 60 ℃ to obtain a water phase system;

Embodiment 3, a washing-free disinfecting skin-care cream, which comprises the following raw materials in parts by weight:

70 parts of ethanol, 3 parts of cetearyl alcohol, 0.2 part of cymene, 5 parts of glycerol, 2.0 parts of propylene glycol, 1.0 part of polydimethylsiloxane, 0.5 part of carbomer, 0.4 part of monoethanolamine, 2.0 parts of cetearyl glucoside, 0.8 part of hydroxyethyl cellulose, 0.1 part of hyaluronic acid, 1 part of dioctyl carbonate and 15 parts of deionized water.

The method comprises the following steps:

(1) preparation of an oil phase system: mixing the liquid oil, the emulsifier and the emollient, and heating in water bath to 70 ℃ to obtain an oil phase system;

And (3) effect comparison:

in the components of the invention, cetearyl alcohol, cymene, glycerol, propylene glycol, polydimethylsiloxane, carbomer, monoethanolamine, cetearyl glucoside, hydroxyethyl cellulose, hyaluronic acid and dioctyl carbonate are adopted, and compared with the moisturizing effect of a blank 62% ethanol group, the moisturizing effect of a sample prepared according to the specific proportion of the embodiment 1 is obviously better than that of the blank product.

See tables 1 and 2 for experimental results:

as can be seen from table 1, the sample of example 1 of the present invention was verified by a challenge experiment: are non-irritant and allergic.

As can be seen from table 2, the water content of the leave-on disinfecting skin cream of example 1 of the present invention was increased by 16.07%, 9.28% and 4.10% at 1, 3 and 5 hours, respectively, as compared to the blank group.

Physical and chemical indexes:

the washing-free disinfecting skin-care cream is emulsion-shaped, light and moist and is easy to apply.

The pH value is measured to be 3.5-5.0.

Cold and hot test: putting the product into a transparent sealed glass bottle, refrigerating the product in a refrigerator at minus 10 ℃ for 3 months, and observing the product without deterioration; the phenomenon of layering and oil-water separation is avoided after the temperature of the constant temperature box is kept at 48 ℃ for three months; the fragrance has no obvious change.

Room temperature standing test: the sealed container is placed for 1 year at room temperature, and has no change in physical and chemical indexes, no oil-water separation and no deterioration.

Stimulation test: the experimental data are shown in table 1.

Table 1 example 1 results of multiple skin irritation tests on new zealand rabbits:

；

the results of the leave-on disinfecting skin care cream and 62% ethanol moisturizing test of example 1 are shown in fig. 1; the comparison result of the leave-on disinfecting skin care cream of example 1 and the moisturizing water content increase value of the 62% ethanol control is shown in fig. 2; the control group with 62% ethanol has 3.5% water loss in 1 hour, and can reach self-equilibrium in about 5 hours. In the embodiment 1 of the invention, the skin moisture is increased by 12% after 1 hour and 4% after 5 hours, so that the effects of moistening and protecting the skin are achieved, and the problems of dry and rough skin caused by alcohol disinfectant are reduced. Comparing the two products, 1 hour this product example 1 has 16.07% higher water content than 62% ethanol, 9.28% higher water content in 3 hours, and 4.10% higher water content in 5 hours.

Note: the average moisture content of the initial test persons was 50%.

Table 2 flash point data table for ethanol at different concentrations:

flash Point (. degree.C.)	100 percent of ethanol	80 percent of ethanol	60 percent of ethanol	Ethanol 40%	20 percent of ethanol	Ethanol content is 10%	Ethanol	5%
									Chemical safety engineering	9	19	22.75	26.75	36.75	49	62

；

Table 3 flash point data for raw materials used in example 1 of leave-on disinfecting skin cream:

flash Point (. degree.C.)	Ethanol	Cetostearyl alcohol	Glycerol	Propylene glycol	Polydimethylsiloxane	Carbonic acid dioctyl ester	Cetearyl glucoside
								Derived from feedstock MSDS	9	174	160	103	103	93	180

；

The method for testing the flash point of the disposable disinfection skin-care cream in example 1 of the disposable disinfection skin-care cream in GB/T T21615-2008 'dangerous goods flammable liquid closed cup flash point test method' is adopted, the flash point is 24.55 ℃, the flash point is increased, and the safety of alcohol disinfectants is improved.

In the example 1, the components such as the emulsifier, the thickener and the grease form a uniform emulsifying system with ethanol and water, ethanol is coated, the surface volatilization of the ethanol is reduced, the saturated air pressure of 26.51mmHg can be reached only at higher temperature, and the flash point of the components in the example can be improved by adding a special manufacturing process for treatment.

The results of the leave-on disinfecting skin cream and 65% ethanol moisturizing test of example 2 are shown in fig. 3; the comparison result of the leave-on disinfecting skin care cream of example 2 with the moisturizing water content increase value of the 65% ethanol control is shown in fig. 4; the control group had 65% ethanol, 3.8% water loss in 1 hour, and self-equilibrium could be reached only in about 5 hours. In the embodiment 2 of the invention, the skin moisture is increased by 14% after 1 hour and 5% after 5 hours, so that the long-acting moisturizing effect of moisturizing and protecting the skin is achieved. The problems of dry and rough skin caused by alcohol disinfectant are reduced. Comparing the two products, 1 hour this product, example 2, had 18.25% higher water content than 65% ethanol, 10.93% higher water content in 3 hours, and 5.17% higher water content in 5 hours.

The method for testing the flash point of the disposable disinfection skin-care cream 2 in GB/T T21615-2008 'dangerous goods flammable liquid closed cup flash point test method' is adopted to test that the flash point is 24.05 ℃, the flash point is increased, and the safety of alcohol disinfectants is improved.

The results of the leave-on disinfecting skin cream of example 3 and the 70% ethanol moisturizing test are shown in fig. 5; the comparison result of the leave-on disinfecting skin care cream of example 3 with the moisturizing water content increase value of the 70% ethanol control is shown in fig. 6; the control group with 70% ethanol has 4.2% water loss in 1 hour, and can reach self-equilibrium in about 5 hours. In the embodiment 3 of the invention, the skin moisture is increased by 12.5% after 1 hour and 5.1% after 5 hours, so that the long-acting moisturizing effect of moistening and protecting the skin is achieved. The problems of dry and rough skin caused by alcohol disinfectant are reduced. Comparing the two products, example 3 has a water content of 17.6% higher than 70% ethanol, 11.35% higher in 3 hours, and 5.36% higher in 5 hours for 1 hour

GB/T T21615-2008 'dangerous goods flammable liquid closed cup flash point test method' is adopted to determine that the flash point of the no-clean disinfection skin-care cream example 3 is 23.35 ℃, the flash point is increased, and the safety of alcohol disinfectants is improved.

Note: 62-75% alcohol as a disinfectant is highly safe to the skin, and the skin irritation test is not repeated in the inventive examples 2 and 3.

The invention has obviously better moisturizing effect than that of the blank control of ethanol with the same concentration, is easy to carry and use in the state of cream, is convenient to smear and saves raw materials.

The foregoing is illustrative of the best mode of the invention and details not described herein are within the common general knowledge of a person of ordinary skill in the art. The scope of the present invention is defined by the appended claims, and any equivalent modifications based on the technical teaching of the present invention are also within the scope of the present invention.

Claims

1. The no-clean disinfection skin-care cream is characterized by comprising the following components in parts by weight:

2. The leave-on disinfecting skin cream of claim 1, wherein: the bactericide is cymene or chlorhexidine acetate.

3. The leave-on disinfecting skin cream of claim 1, wherein: the humectant is glycerol, propylene glycol, polyethylene glycol, and hyaluronic acid.

4. The leave-on disinfecting skin cream of claim 1, wherein: the thickener is carbomer, hydroxyethyl cellulose and xanthan gum.

5. The leave-on disinfecting skin cream of claim 1, wherein: the oil is cetostearyl alcohol, behenyl alcohol or stearyl alcohol.

6. The leave-on disinfecting skin cream of claim 1, wherein: the emollient is polydimethylsiloxane, dioctyl carbonate, cyclomethicone and dimethiconol.

7. The leave-on disinfecting skin cream of claim 1, wherein: the neutralizer is monoethanolamine, aminomethyl propanol, sodium hydroxide, citric acid and lactic acid.

8. The leave-on disinfecting skin cream of claim 1, wherein: the emulsifier is ceteareth, steareth, cetearyl glucoside.

9. The method for preparing a leave-on disinfecting skin cream as claimed in claim 1, which comprises: