CN111265768A - A kind of personalized intelligent drug delivery device and method based on microneedle - Google Patents

Abstract

The invention discloses a micro-needle-based personalized intelligent drug delivery device and method, comprising an excitation device and a fracture auxiliary substrate. The back of the fracture auxiliary substrate is provided with a sealing cover plate, and the fracture auxiliary substrate is provided with a plurality of holes. Drug-loading microneedles are respectively provided on the inner surface of the substrate corresponding to the positions of each hole, and excitable materials are provided in the holes. It can intelligently realize personalized drug delivery and treatment according to the type and area of lesions, and can intelligently complete personalized diagnosis-treatment in the absence of doctors, helping to maximize the utilization of medical resources and greatly improving the incidence of skin diseases. treatment efficiency.

Description

A kind of personalized intelligent drug delivery device and method based on microneedle

technical field

The invention relates to a technology for improving drug delivery efficiency and intelligent drug delivery for skin diseases, and in particular to a microneedle-based personalized intelligent drug delivery device and method.

Background technique

At present, the total number of dermatological outpatients is increasing every year, of which psoriasis, vitiligo, alopecia, melanoma, warts and other refractory skin diseases account for a considerable part.

Systemic administration by oral, injection, transdermal, etc. is the most common method for the treatment of skin diseases, especially for some lesions related to various pathological conditions. Oral drugs can damage the liver and disrupt the activity of protein-based drugs; although injections are highly efficient, they are prone to adverse reactions, trauma and pain.

Relatively speaking, transdermal drug delivery has significant advantages: the drug can be conveniently transported directly into the blood or lymphatic circulation, which reduces individual differences in drug administration; a constant drug delivery rate can avoid the phenomenon of peaks and valleys in blood drug concentration; the drug can be interrupted at any time. medicine, with greater convenience and compliance. But the stratum corneum in the skin prevents drugs, especially macromolecules and non-aqueous drugs, from entering the body through natural diffusion mechanisms.

In the prior art, a microneedle composed of a needle-like structure with a scale of 100 microns can pierce the stratum corneum of the skin in a painless manner, and the resulting penetration channel can easily improve the diffusion efficiency of the drug by several orders of magnitude, and also Causes infections and allergic reactions. There are individual differences between skin lesions, and the type of drug must be determined according to the type of lesion, and the dosage of the same lesion should also be adjusted during treatment.

At present, different types of microneedles of various materials have been developed, including solid microneedles, hollow microneedles, drug-coated microneedles, and soluble microneedles, but none of them can achieve personalized drug treatment.

SUMMARY OF THE INVENTION

The purpose of the present invention is to provide a personalized smart drug delivery device and method based on microneedles.

The purpose of this invention is to realize through the following technical solutions:

The personalized intelligent drug delivery device based on microneedles of the present invention includes an excitation device and a fracture auxiliary substrate, a sealing cover plate is provided on the back of the fracture auxiliary substrate, and a plurality of holes are arranged in the fracture auxiliary substrate. The inner surface of the auxiliary substrate is provided with drug-carrying microneedles at positions corresponding to each hole, and the holes are provided with excitable materials.

The above-mentioned microneedle-based personalized intelligent drug delivery device of the present invention realizes the method for drug delivery, comprising the steps of:

Place the lesion area to the designated position of the skin diagnostic equipment implanted with the neural network model;

Skin diagnosis completes the identification of lesion types and regional segmentation by taking pictures of the target area, and the obtained data is used to guide the selection of drugs and determine the excitation area during the drug administration process;

Select suitable substrate materials and drugs based on the identified lesion type;

Preparation of drug-loaded microneedles with selective excitation and fracture;

Apply the microneedle to the lesion area, complete the scanning of the administration area according to the acquired area segmentation data, and complete the excitation of the cavitation material in the microneedle with the help of the excitation device to break the microneedle;

Complete personalized intelligent drug delivery and evaluate through efficacy.

It can be seen from the technical solutions provided by the present invention that the microneedle-based personalized intelligent drug delivery device and method provided by the embodiments of the present invention can intelligently realize personalized drug delivery treatment according to the type and area of the lesion, and can be used by doctors. It can intelligently complete personalized diagnosis-treatment in the absence of a person, help maximize the utilization of medical resources, and greatly improve the treatment efficiency of skin diseases.

Description of drawings

FIG. 1a is a schematic structural diagram of a microneedle-based personalized smart drug delivery device provided by an embodiment of the present invention.

Fig. 1b is an enlarged schematic diagram of part A of Fig. 1a.

FIG. 2 is a schematic flowchart of a microneedle-based personalized smart drug delivery method provided by an embodiment of the present invention.

In the picture:

1. Stimulated fracture microneedles, 2. Drug-loaded microneedles, 3. Excitable materials, 4. Exciting equipment, 5. Cavitation, 6. Sealing cover plate, 7. Breaking auxiliary substrate.

Detailed ways

The embodiments of the present invention will be described in further detail below. Contents that are not described in detail in the embodiments of the present invention belong to the prior art known to those skilled in the art.

The preferred specific embodiment of the microneedle-based personalized intelligent drug delivery device of the present invention is:

It includes an excitation device and a fracture auxiliary substrate, the back of the fracture auxiliary substrate is provided with a sealing cover, a plurality of holes are arranged in the fracture auxiliary substrate, and the inner surface of the fracture auxiliary substrate is respectively provided with a carrier corresponding to the position of each hole. Medicine microneedles, the holes are provided with excitable materials.

The drug-loaded microneedles are arranged coaxially with the holes on the fracture auxiliary substrate, and the root size of the drug-loaded microneedles is 110%-125% of the radial size of the holes.

The excitable material is a material that can expand several times by volume cavitation after being excited under specific conditions. For example, the excitable material is a PFC-encapsulated liposome microcapsule.

The height of the drug-loaded microneedles is ~700 microns.

The excitation device is a laser excitation device capable of emitting a specific wavelength.

The above-mentioned microneedle-based personalized intelligent drug delivery device of the present invention realizes the method for drug delivery, and its preferred specific embodiment is:

Include steps:

Place the lesion area to the designated position of the skin diagnostic equipment implanted with the neural network model;

Skin diagnosis completes the identification of lesion types and regional segmentation by taking pictures of the target area, and the obtained data is used to guide the selection of drugs and determine the excitation area during the drug administration process;

Select suitable substrate materials and drugs based on the identified lesion type;

Preparation of drug-loaded microneedles with selective excitation and fracture;

Apply the microneedle to the lesion area, complete the scanning of the administration area according to the acquired area segmentation data, and complete the excitation of the cavitation material in the microneedle with the help of the excitation device to break the microneedle;

Complete personalized intelligent drug delivery and evaluate through efficacy.

It includes a set of intelligent skin disease diagnosis system, the skin disease intelligent diagnosis system includes a camera and a processing unit, and a neural network trained by deep learning is implanted, which can intelligently realize the segmentation of lesion type and lesion area.

The micro-needle-based personalized intelligent drug delivery device and method of the present invention can intelligently realize personalized drug administration and treatment according to the type and area of lesions, and can intelligently complete personalized diagnosis-treatment in the absence of a doctor, helping to achieve The maximum utilization of medical resources can also greatly improve the treatment efficiency of skin diseases.

Specific examples:

As shown in Figure 1a and Figure 1b, it includes a set of intelligent diagnosis system for skin diseases, excitation equipment, and microneedles that can be selectively excited and broken.

The intelligent skin disease diagnosis system is composed of a camera and a processing unit, and is implanted with a neural network trained by deep learning, which can intelligently realize the segmentation of lesion types and lesion areas.

The excitation device completes the excitation of the cavitated material in the microneedle by emitting a laser of a specific wavelength to break the microneedle, which can be realized by means of area projection or point scanning.

The selectively excited-fractured microneedles consist of microneedles, excitable materials, a fracture-assisting substrate, and a sealing cover plate (Fig. 1a).

The microneedles were fabricated at a position coaxial with the holes on the fracture assistant substrate, and the size of the root of the microneedles was slightly larger than the size of the holes on the fracture assistant substrate (between 110% and 125%) (Fig. 1b). Too large a contact area would result in insufficient driving force for the excitable material, while too small a contact area would result in the ineffective extraction of the microneedles after insertion.

The force provided by the contact area between the microneedle and the fracture auxiliary substrate is the basis for the insertion of the microneedle into the tissue, and also the source of the force for the complete extraction of the microneedle outside the lesion area after the treatment is completed.

The excitable material sealed in the hole of the fracture auxiliary substrate can be cavitated under certain conditions. Under the premise that the contact area between the microneedle and the fracture auxiliary substrate is lower than a certain range, the driving force brought by the instantaneous volume expansion can control the microneedle. fracture. Excitable materials are biocompatible, such as PFC-encapsulated liposome microcapsules.

The drug-loaded microneedles, with a height of about 700 microns, can be prepared by 3D printing or casting.

After the personalized medicine is completed, the microneedles that are pulled out have no sharp objects and no toxicity, and can be treated as ordinary medical waste without causing pollution to the environment.

The workflow of personalized intelligent drug delivery based on microneedle is shown in Figure 2, which is expressed in words as follows:

Place the lesion area to the designated position of the skin diagnostic equipment implanted with the neural network model

Skin diagnosis completes the classification of lesions and segmentation by taking pictures of the target area. The obtained data are used to guide the selection of drugs and determine the excitation area during the drug administration process.

Selection of suitable substrate materials and drugs based on the discriminated lesion type

The selective excitation-fractured microneedles shown in Figure 1a were prepared according to the process

Apply the microneedle to the lesion area, and complete the scan of the administration area according to the acquired area segmentation data with the help of the vertex excitation device

Complete personalized smart drug delivery and evaluate through efficacy

Advantages and positive effects of the present invention:

Personalized painless transdermal drug delivery can be completed according to the type of skin disease and the lesion area, and the operation is convenient.

The selective fracture microneedles used are all prepared from biodegradable or compatible materials, the drug loading can be quickly adjusted, the preparation process is simple, and it is easy to popularize.

Microneedles do not have sharp objects and toxicity, and can be treated as ordinary medical waste without polluting the environment.

The personalized drug delivery method of this technology can shorten the treatment time and reduce the pain of treatment, and can also help maximize the utilization of medical resources.

The above description is only a preferred embodiment of the present invention, but the protection scope of the present invention is not limited to this. Substitutions should be covered within the protection scope of the present invention. Therefore, the protection scope of the present invention should be based on the protection scope of the claims.

Claims (8)

1. The utility model provides a device of dosing of individualized intelligence based on micropin, its characterized in that, is including arousing equipment and fracture auxiliary base plate, the back of fracture auxiliary base plate is equipped with sealed apron, be equipped with a plurality of holes in the fracture auxiliary base plate, the position that the inner face of fracture auxiliary base plate corresponds every hole is equipped with the medicine carrying micropin respectively, be equipped with in the hole and arouse the material.

2. A microneedle-based personalized intelligent drug delivery device according to claim 1, wherein the drug-loaded microneedles are coaxially arranged with the holes on the fracture assisting substrate, and the root size of the drug-loaded microneedles is 110-125% of the radial size of the holes.

3. A microneedle-based personalized smart drug delivery device according to claim 2, wherein the excitable material is a material that can be expanded by several times by volume cavitation after being excited under specific conditions.

4. A microneedle-based personalized smart drug delivery device according to claim 3, wherein the excitable material is a liposome microcapsule encapsulating PFC.

5. The personalized smart microneedle-based drug delivery device of claim 4, wherein the drug-loaded microneedles are between 700 microns in height.

6. A microneedle-based personalized smart drug delivery device according to claim 5, wherein the excitation device is a laser excitation device capable of emitting a specific wavelength.

7. A method for enabling drug delivery by a microneedle-based personalized smart drug delivery device according to any one of claims 1 to 6, comprising the steps of:

placing the lesion area to a specified position of skin diagnosis equipment implanted with a neural network model;

the skin diagnosis is to take a picture of a target area to finish the judgment and the area segmentation of the lesion type, and the obtained data are respectively used for guiding the selection of the medicine and determining the excitation area in the administration process;

selecting a suitable base material and drug based on the discriminated lesion type;

preparing a drug-loaded microneedle capable of selectively exciting fracture;

applying the micro-needle to the lesion area, finishing scanning of the administration area according to the acquired area segmentation data, and finishing the excitation of the hollow material of the micro-needle to break the micro-needle with the help of the excitation equipment;

personalized intelligent dosing is completed and the evaluation is carried out through the curative effect.

8. The microneedle-based personalized intelligent drug delivery method according to claim 7, comprising a set of intelligent diagnosis system for skin diseases, wherein the intelligent diagnosis system for skin diseases comprises a camera and a processing unit, and a neural network trained by deep learning is implanted, so that the segmentation of lesion types and lesion regions can be intelligently realized.

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