CN111110618B

CN111110618B - A composition for promoting hair growth

Info

Publication number: CN111110618B
Application number: CN202010086464.4A
Authority: CN
Inventors: 张运适; 李梅
Original assignee: Individual
Current assignee: Zhang Yunshi
Priority date: 2020-02-11
Filing date: 2020-02-11
Publication date: 2022-09-27
Anticipated expiration: 2040-02-11
Also published as: CN111110618A

Abstract

The invention relates to the technical field of skin care products, in particular to a composition for promoting hair growth, which mainly comprises 1-30% of ginger extract, 0.5-5% of adenosine, 0.005-0.1% of tripeptide-1 copper, 0.5-8% of nicotinamide and the balance of deionized water by mass percentage. Compared with the prior art, the composition has good synergistic effect by using the combination of the four effective components, can effectively stimulate the hair growth, has obvious effects of preventing hair loss and strengthening hair, and can effectively reduce the using amount of high-price raw materials under the condition of achieving the same effect, so that the whole product has higher cost performance, thereby being popularized and used in more consumers and improving the market competitiveness of the product.

Description

A composition for promoting hair growth

Technical Field

The invention relates to the technical field of skin care products, in particular to a composition for promoting hair growth.

Background

Alopecia refers to the phenomenon of hair loss. The normal hair loss is the hair in the catagen and the telogen periods, and the normal amount of hair can be maintained because the hair entering the catagen period and the hair newly entering the anagen period are constantly in dynamic balance. Pathological hair loss refers to abnormal or excessive hair loss, which is caused by many reasons. The most common type of hair loss is "male pattern hair loss", otherwise known as "male pattern hair loss" or "seborrheic pattern hair loss", which accounts for approximately 95% of the hair loss population. The main cause of "male hair loss" is the stimulation of hair follicles by Dihydrotestosterone (DHT). In addition to male pattern alopecia, the alopecia types include alopecia areata, psychogenic alopecia, endocrine dysregulated alopecia, nutritional metabolic alopecia, chemical alopecia, etc. In addition, hair loss can also be caused by improper selection and use of hair cosmetics such as shampoos, permanent wave agents, hair dyes, and the like.

In terms of medical treatment, Minoxidil (Minoxidil) is a drug currently used clinically for hair treatment, which is found in the united states, and FDA approval of topical use of 2% Minoxidil in men and women allows a large proportion of men and women with male hereditary alopecia to grow macroscopic hairs. In addition, as a drug for promoting eyelash growth, there is horse prostamide (also called bemeprostinil, leucin, etc.), which is a component contained in Lumigan (rumor root) for glaucoma treatment, produced by american eye health (AMO) corporation in 2006, and which promotes eyelash growth, and thus, is used as a raw material for producing eyelash growth liquid by many cosmetic companies.

In the cosmetic field, in the last eighties and ninety years, the treatment effect of copper peptide in hair hyperplasia is discovered in the United states, the copper peptide mainly stimulates hair roots and follicles to generate hair, and the copper peptide is used as a raw material in hair growth and care products. Plant extracts, such as thuja extract, polygonum multiflorum root extract, etc., are also widely used in anti-alopecia daily chemical products.

However, the single raw material has a poor effect of growing and restoring hair, which is satisfactory to consumers, and the effect is unstable. On the other hand, some products with certain hair growth effect in the market mostly adopt high-price raw materials and use amount, so that the cost is higher, and the products are difficult to popularize and use in mass consumers. Therefore, there is a high necessity for developing a product having a hair growth promoting effect, a good stability and a high cost performance to improve market competitiveness.

Disclosure of Invention

The present invention has been made in view of the above-mentioned problems occurring in the prior art, and an object of the present invention is to provide a composition for promoting hair growth, which has excellent hair growth promoting effects, high stability, low cost, and high cost performance.

The purpose of the invention is realized by the following technical scheme:

the composition for promoting hair growth comprises the following raw materials in percentage by mass:

in the above technical scheme, the composition for promoting hair growth comprises the following raw materials by mass percent:

in the technical scheme, the composition further comprises 0.05-0.2% of preservative by mass. Preferably, the preservative is methyl paraben.

In the technical scheme, the soluble solid content in the ginger extracting solution is higher than 25%.

In the technical scheme, the composition is in any one of a solution, an emulsion, a gel, a solid, a freeze-dried powder and a liposome.

In the above technical scheme, the hair is hair, eyebrow or eyelash.

In the formula:

the ginger juice can cause scalp congestion, promote effective circulation of blood, and promote nutrient absorption of hair roots, thereby reducing alopecia and dandruff; the ginger juice can also sterilize, and can effectively clean garbage and grease accumulated on the scalp, namely reduce the excessive grease secreted by the scalp. However, pure ginger juice contains a large amount of gingerol, and this component is considered to have a hair growth inhibitory effect. Because gingerol is slightly soluble in water, the invention uses the ginger extract which is extracted by water, thereby avoiding the side effect of high-concentration gingerol on hair.

Adenosine, a chemical component present in human cells, has been studied to show that adenosine has a function of promoting blood circulation. Adenosine can stimulate hair growth, promote multiple growth factors in scalp such as FGF-7 factor, and has positive effect on hair growth. It also has the main characteristic of acting directly on dermal papilla cells, which play an important role in the growth of new and existing hair.

The tripeptide copper-1, also called copper peptide, has been studied for 20 years since the 1970 s for use in skin care products and is still considered to be one of the most effective skin regeneration actives today. Studies have shown that copper peptide promotes the production of collagen and elastin, and that it also acts as an antioxidant; in addition, it can promote aminodextran. The ability of copper to aid hair growth was discovered because the hair follicles surrounding the wound were found to be particularly large when the wound was treated. It acts on hair follicles in two ways: increasing the number of hair follicle cells; copper peptides also reduce the death of hair follicle cells, which results in hair follicle miniaturization. In a study of rat hair, the investigators noted an increase in hair follicle size, indicating that copper peptide works similarly to minoxidil for hair growth.

Nicotinamide, an amide compound of nicotinic acid, exists in the human body as a nutrient substance, causes pellagra in the absence of nicotinamide in the body, plays a role in the metabolism of proteins and sugars, improves the nutrition of humans and animals, and thus can be used as a nutritional additive in cosmetics. Nicotinamide is a well-known skin anti-aging ingredient in the field of beauty skin science, and is more and more important in recent years, and the most important effect of the niacinamide on skin anti-aging is to relieve and prevent dark, yellow and vegetable color of skin color generated in the early aging process of skin. Of course, niacinamide contributes much more than just to the skin, but also repairs the damaged stratum corneum lipid barrier, increasing skin resistance; in addition, it is also used as medicine, food and feed additive. The inventor finds that the nicotinamide externally applied to the hair part can achieve better effects of nourishing hair follicles and scalp, slow down the aging degree of the scalp and improve the health degree of scalp cells, thereby assisting in promoting the growth of the hair.

The action mechanism of the components of the formula of the invention is as follows:

among the main four components of the composition, the ginger extract plays a role in promoting blood circulation and promoting the blood circulation of capillary vessels at the root of hair; adenosine can activate various growth factors and promote hair growth; tripeptide-1 copper may increase the number of hair follicle cells and reduce the death of hair follicle cells; nicotinamide can provide nutrition for scalp, supplement nutrients required by cells, and nourish hair roots. Compared with the prior art, the invention has the following advantages through the synergistic effect of the four main components:

(1) the hair growth-preventing and hair-fixing agent has a good synergistic effect by using the combination of the four active ingredients, can effectively stimulate hair growth, has obvious hair loss prevention and hair fixing effects, can obtain a more stable hair growth effect than any single ingredient, and has a wider effective population than the single ingredient;

(2) the invention has higher cost performance, under the condition of reaching the same effect, the four effects selected by the invention are combined, the use amount of high-price raw materials can be effectively reduced, the preparation process is simple, the whole product has higher cost performance, and the invention is popularized and used in more consumers, thereby improving the market competitiveness.

Drawings

Fig. 1 is a graph comparing hair growth and hair loss effects of examples 1 to 2 of the present invention and comparative examples 1 to 4.

Detailed Description

The present invention will be described in further detail with reference to specific examples, but the present invention is not limited to these examples.

Example 1:

adding ginger extract, adenosine, tripeptide-1 copper and nicotinamide into deionized water according to the following proportion, adding 0.15 wt% of methyl hydroxybenzoate as a preservative, and stirring until the components are completely dissolved uniformly for later use.

Raw materials	Ratio of
		Ginger extract	1wt％
Adenosine (I)	0.5wt％
		Tripeptide-1 copper	0.01wt％
Nicotinamide	0.5wt％
		Nippon methyl ester	0.15wt％
Deionized water	97.84wt％

Example 2:

Raw materials	Ratio of
		Ginger extract	10wt％
Adenosine (I)	2wt％
		Tripeptide-1 copper	0.02wt％
Nicotinamide	4wt％
		Nippon methyl ester	0.15wt％
Deionized water	83.80wt％

Example 3:

adding ginger extract, adenosine, tripeptide-1 copper and nicotinamide into deionized water according to the following proportion, adding 0.15 wt% of methyl paraben serving as a preservative, and stirring until the components are completely dissolved uniformly for later use.

Raw materials	Ratio of
		Ginger extract	20wt％
Adenosine (I)	3wt％
		Tripeptide-1 copper	0.04wt％
Nicotinamide	3wt％
		Nippon methyl ester	0.2wt％
Deionized water	73.76wt％

Example 4:

Raw materials	Ratio of
		Ginger extract	5wt％
Adenosine (I)	1wt％
		Tripeptide-1 copper	0.1wt％
Nicotinamide	5wt％
		Nippon gold methyl ester	0.05wt％
Deionized water	88.85wt％

Comparative example 1:

adding the ginger extract into deionized water according to the following proportion, adding 0.15 wt% of methyl nicotinate as a preservative, and stirring until the mixture is completely and uniformly dissolved for later use.

Raw materials	Ratio of
		Ginger extract	30wt％
Nippon methyl ester	0.15wt％
		Deionized water	69.85wt％

Comparative example 2:

adding adenosine into deionized water according to the following proportion, adding 0.15 wt% of methyl nicotinate as a preservative, and stirring until the adenosine is completely dissolved uniformly for later use.

Raw materials	Ratio of
		Adenosine (I)	5wt％
Nippon methyl ester	0.15wt％
		Deionized water	94.85wt％

Comparative example 3:

tripeptide-1 copper is added into deionized water according to the following proportion, 0.15 wt% of nylon methyl ester is added to serve as a preservative, and the mixture is stirred until the tripeptide-1 copper is completely dissolved for later use.

Raw materials	Ratio of
		Tripeptide-1 copper	0.1wt％
Nippon methyl ester	0.15wt％
		Water (W)	99.75wt％

Comparative example 4:

adding nicotinamide into deionized water according to the following proportion, adding 0.15 wt% of methyl nicotinate as preservative, and stirring until the nicotinamide is completely dissolved uniformly for later use.

Raw materials	Ratio of
		Nicotinamide	8wt％
Nippon methyl ester	0.15wt％
		Water (I)	91.85wt％

And (3) evaluating the efficacy:

the method for characterizing hair growth promotion used in the present invention is a clinical test, wherein a total of 90 male alopecia patients, 30-55 years old and 41 years old as the average age, are randomly divided into 3 groups of 30 persons each. The tests were carried out using the products of examples 1 to 2 and comparative examples 1 to 4, respectively.

The test method comprises the following steps: each patient's hair is divided into left and right halves along the midline of the skull, each half being treated with a hair restorer. A total of 6 hair restorers were used by 3 groups. 4ml of hair growth liquid is smeared on the baldness part once in the morning and at night for 3 months, and the hair loss condition and new hair growth condition before and after the test of three groups of patients are compared.

The test was carried out according to the test method described above, and after 3 months, the hair loss condition and new hair growth condition before and after the test were compared among three groups of patients. The test results are shown in FIG. 1. The ordinate represents the effective rate of hair loss and hair growth (i.e. effective number/total number 100%) of the consumers. The test results show that examples 1 and 2 are far more effective in patients with hair loss and hair growth than the four comparative examples using a single ingredient. Especially, the effective situation of the optimized formula in the example 2 is more remarkable.

From the results of comparing the costs of the raw materials of the formulations of examples 1 to 2 and comparative examples 1 to 4, as shown in table 1, it can be seen from the cost comparison that: example 1 has a very low cost while having a better hair growth effect than any of the comparative examples. Example 2 has the best hair growth effect and relatively low cost.

TABLE 1 comparison of raw material costs for formulations of examples 1 to 2 and comparative examples 1 to 4

Sample(s)	Price
		Example 1	14 yuan/kg
Example 2	50 yuan/kg
		Comparative example 1	60 yuan/kg
Comparative example 2	15 yuan/kg
		Comparative example 3	100 yuan/kg
Comparative example 4	8 yuan/kg

Through the comparison, the hair growth-preventing and hair-fixing agent has a good synergistic effect by using the combination of the four effective components, can effectively stimulate the hair growth, has an obvious hair loss-preventing and hair-fixing effect, can obtain a better and more stable hair growth effect than any single component, and has a wider effective population than the single component; on the other hand, under the condition of achieving the same effect, the invention can effectively reduce the using amount of high-price raw materials, so that the whole product has higher cost performance, and can be popularized and used in more consumers to improve market competitiveness.

The above-mentioned embodiments are only for convenience of description, and are not intended to limit the present invention in any way, and those skilled in the art will understand that the technical features of the present invention can be modified or changed by other equivalent embodiments without departing from the scope of the present invention.

Claims

1. A composition for promoting hair growth, characterized by: the material comprises the following raw materials in percentage by mass:

1 to 30 percent of ginger extract

Adenosine 0.5-5%

Tripeptide-1 copper 0.005-0.1%

0.5 to 8 percent of nicotinamide

The balance of deionized water;

the composition also comprises 0.05-0.2% of preservative by mass percent;

the ginger extract is a water-extracted ginger extract, and the soluble solid content in the ginger extract is higher than 25%.

2. A composition for promoting hair growth according to claim 1, wherein: the material comprises the following raw materials in percentage by mass:

5 to 20 percent of ginger extract

Adenosine 1-3%

Tripeptide-1 copper 0.01-0.04%

3 to 5 percent of nicotinamide

The balance of deionized water;

the composition also comprises 0.05-0.2% of preservative by mass percent.

3. A composition for promoting hair growth according to claim 1 or 2, wherein: the preservative is methyl paraben.

4. A composition for promoting hair growth according to claim 1, wherein: the composition is in the form of any one of solution, emulsion, gel, solid, freeze-dried powder and liposome.

5. A composition for promoting hair growth according to claim 1, wherein: the hair is hair, eyebrow or eyelash.