CN111089979A - Sample analyzer and reagent scanning method - Google Patents

Abstract

The embodiment of the invention discloses a sample analyzer, which comprises a scanning device, a plurality of reagent racks and a rotatable reagent table, wherein the reagent racks are arranged on the scanning device; the reagent table is divided into an inner area and an outer ring area, and the outer ring area surrounds the inner area; a plurality of reagent racks are arranged on the outer ring area in a radial mode around the center of the inner area, and the inner area is not provided with the reagent racks or reagent positions; the reagent rack is provided with a plurality of reagent positions for placing reagent containers; the reagent positions surround the center of the inner area and are arranged on the reagent rack in a staggered manner; the reagent positions are arranged in the radiation direction taking the center of the inner area as the radiation center, different reagent positions correspond to different radiation directions, and the reagent positions are provided with scanning ports towards the radiation direction so that the scanning device can identify the reagent containers on the reagent positions in a scanning mode; taking the distance between the reagent position and the center of the inner area as a central distance, and arranging at least two reagent positions with different central distances on the reagent rack; the reagent position is correspondingly provided with a position mark, and the scanning device identifies the position mark of the reagent position in a scanning mode.

Description

A kind of sample analyzer and reagent scanning method

technical field

Embodiments of the present invention relate to the field of biochemical instruments, and relate to, but are not limited to, a sample analyzer and a reagent scanning method.

Background technique

The barcode identification system is widely used in medical instruments, for example, in a sample analyzer, and the sample (reagent) information in the sample analyzer is identified by a scanning device. Due to the constraints of the size of the whole machine, the reagent racks are usually designed in a multi-layer structure, for example, there are two types of reagent racks, linear reagent racks and disc-shaped distribution reagent racks. Whether it is a linear reagent rack or a disk-shaped reagent rack, when scanning the barcode on the reagent rack, the barcode on the reagent rack is usually controlled to move to the scanning device for the scanning device to scan and identify. Therefore, how to design the distribution of the reagent racks on the reagent table to reduce the complexity of the scanning process has become a problem that needs to be solved at present.

SUMMARY OF THE INVENTION

In view of this, embodiments of the present invention provide a sample analyzer and a reagent scanning method to solve at least one problem existing in the related art.

The technical solution of the embodiment of the present invention is realized as follows:

In a first aspect, an embodiment of the present invention provides a sample analyzer, including a scanning device, a plurality of reagent racks, and a rotatable reagent table; wherein,

The reagent table is divided into an inner area and an outer ring area, and the outer ring area surrounds the inner area;

The plurality of reagent racks are radially arranged on the outer ring area around the center of the inner area, and the inner area is not provided with reagent racks or reagent positions;

Each reagent rack is provided with a plurality of reagent positions for placing reagent containers; the reagent positions surround the center of the inner area and are staggered on the reagent rack; each reagent position is arranged in the interior The center of the area is the radiation direction of the radiation center, different reagent positions correspond to different radiation directions, and each reagent position is provided with a scanning port toward the radiation direction, so that the scanning device can identify the reagent position by scanning. The reagent container; with the distance between the reagent position and the center of the inner area as the center distance, each reagent rack is provided with at least two reagent positions with different center distances; each reagent position is correspondingly provided with a unique Position identification, the scanning device can identify the unique position identification of each reagent position by scanning.

In a second aspect, an embodiment of the present invention provides a reagent scanning method, the method is applied to the above-mentioned sample analyzer, and the method includes:

Determine the theoretical number and the actual number of reagent containers between the two unique position identifiers before and after the scan;

According to the theoretical number of the reagent containers and the actual number of the reagent containers, determine the unique location identifier that is missed between the two unique location identifiers before and after;

Inserting the unique location identifier of the missed scan into a position corresponding to the unique location identifier of the missed scan between the two front and rear unique location identifiers.

In an embodiment of the present invention, the sample analyzer includes a scanning device, a plurality of reagent racks and a rotatable reagent table; wherein the reagent table is divided into an inner area and an outer ring area, and the outer ring area surrounds the inner area ; The plurality of reagent racks are radially arranged around the center of the inner region on the outer ring region; each reagent rack is provided with a plurality of reagent positions for placing reagent containers; in this way, only in the outer ring A reagent position is set on the area, so that the sample analyzer only needs to control the movement of the reagent position on the outer ring area to the scanning device, so as to realize the identification of all the reagent containers on the reagent table, without the need for A scanning gap is reserved on the outer ring area to control the movement of the scanning gap to the scanning device, and at the same time the reagent position on the inner area is controlled to move to the scanning gap, thereby reducing the complexity of the sample analyzer to control the scanning process and reducing the Difficulty scanning.

Description of drawings

In the drawings, which are not necessarily to scale, like reference numerals may describe like parts in the different views. Similar reference numbers with different letter suffixes may denote different instances of similar components. The accompanying drawings generally illustrate, by way of example and not limitation, the various embodiments discussed herein.

1 is a schematic diagram of the composition and structure of a sample analyzer according to an embodiment of the present invention;

2A is a schematic structural diagram of another sample analyzer according to an embodiment of the present invention;

2B is a schematic structural diagram of a reagent rack according to an embodiment of the present invention;

3A is a schematic structural diagram of another sample analyzer according to an embodiment of the present invention;

3B is a schematic structural diagram of another reagent rack according to an embodiment of the present invention;

3C is a schematic diagram of the positional relationship between the unique reagent identifier and the unique location identifier according to the embodiment of the present invention;

FIG. 4 is a schematic diagram of an implementation flowchart of a reagent scanning method according to an embodiment of the present invention;

FIG. 5A is a schematic diagram of an implementation flowchart of another reagent scanning method according to an embodiment of the present invention;

FIG. 5B is a schematic diagram of an implementation flowchart of a method for scanning a reagent container according to an embodiment of the present invention;

FIG. 5C is a schematic diagram of an implementation flowchart of another method for scanning a reagent container according to an embodiment of the present invention;

6 is a schematic diagram of the composition and structure of still another sample analyzer according to an embodiment of the present invention;

7 is a schematic diagram of the positional relationship between a reagent code and a position code according to an embodiment of the present invention;

FIG. 8 is a schematic diagram of an implementation flowchart of a scanning method according to an embodiment of the present invention;

FIG. 9 is a schematic diagram of an implementation flowchart of another reagent scanning method according to an embodiment of the present invention.

Detailed ways

The barcode identification system is widely used in medical instruments, for example, in a sample analyzer, and the sample (reagent) information in the sample analyzer is identified by a scanning device. Due to the constraints of the size of the whole machine, the reagent racks are usually designed in a multi-layer structure, for example, there are two types of reagent racks, linear reagent racks and disc-shaped distribution reagent racks. In order to increase the reagent carrying capacity of the reagent table, some sample analyzers are equipped with reagent positions on the inner and outer rings of the reagent table, and a scanning gap is set on the outer ring to control the movement of the reagent position on the inner ring to the scanning gap, so that the scanning The device can identify the reagent container on the inner ring by scanning. However, this adds to the complexity of controlling the scanning process.

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Thereby, the realization process of how the present invention applies technical means to solve technical problems and achieve technical effects can be fully understood and implemented accordingly. It should be noted that, as long as there is no conflict, each embodiment of the present invention and each feature of each embodiment can be combined with each other, and the formed technical solutions are all within the protection scope of the present invention.

In the following description, suffixes such as 'module', 'component' or 'unit' used to represent elements are used only to facilitate the description of the present invention and have no specific meaning per se. Thus, "module", "component" or "unit" may be used interchangeably.

An embodiment of the present invention provides a sample analyzer. FIG. 1 is a schematic structural diagram of a sample analyzer according to an embodiment of the present invention. As shown in FIG. 1 , the sample analyzer 10 includes a scanning device 11 , a rotatable reagent table 12 and a plurality of reagent racks 14 to 1N; wherein, the reagent table 12 is divided into an inner area 121 and an outer ring area 122, the outer ring area 122 surrounds the inner area 121; here, for the inner area 121 The size ratio between the outer ring area 122 and the outer ring area 122 is not limited. In this embodiment, since the reagent rack with multiple reagent positions is arranged on the outer ring area 122, in practical applications, in order to increase the The carrying capacity of the sample analyzer 10 can be set as far as possible to set the outer ring area 122 larger than the inner area 121 , that is, the size between the inner area 121 and the outer ring area 122 The ratio is as small as possible.

The plurality of reagent racks 14 to 1N are radially arranged on the outer ring region 122 around the center 1211 of the inner region 121 , as shown in FIG. 1 , one of the radial directions is marked; Set reagent racks or reagent positions; in this way, only the reagent racks with multiple reagent positions are arranged on the outer ring area 122 , the structure is simpler, and the sample analyzer 10 only needs to control the outer ring area 122 The reagent position moves to the scanning device 11 to realize the identification of all the reagent containers on the reagent table 12 , and since the inner area 121 does not have reagent racks or reagent positions, it does not need to be placed on the outer ring area 122 A scanning gap is reserved to scan the inner area 121, so that the sample analyzer 10 controls the scanning gap to move to the scanning device 11 and also controls the reagent position on the inner area 121 to move to the scanning gap, which can reduce sample analysis. The instrument 10 controls the complexity of the scanning process.

Each reagent rack is provided with a plurality of reagent positions for placing reagent containers; taking the reagent rack 14 as an example, the reagent rack 14 is provided with reagent positions 141 to 14M; the reagent positions surround the inner area 121 The center 1211 of the reagent rack is arranged in a staggered manner on the reagent rack, so that the reagent positions are staggered and arranged on the reagent rack, so that the arrangement of the reagent positions on the reagent rack is more compact, thereby increasing the sample analyzer 10 reagent carrying capacity.

Each reagent position is arranged in the radiation direction with the center 1211 of the inner area 121 as the radiation center (that is, in the direction of radiation from the outer ring area 122 with the center 1211 as the radiation center), and in order to ensure the All reagent containers can be scanned by the scanning device 11. As shown in FIG. 1, different reagent positions correspond to different radiation directions, and each reagent position is provided with a scanning port 13 toward the radiation direction, so that the scanning device 11 can scan The reagent container on the reagent position is identified by the method to ensure that each reagent position can be scanned through the scanning port 13; The reagent container can even obtain reagent information of the reagents it carries.

Taking the distance between the reagent position and the center 1211 of the inner area 121 as the center distance, each reagent rack is provided with at least two kinds of reagent positions with different center distances; for example, in FIG. 1 , on each reagent rack There are three reagent positions with different center distances, that is, there are three inner, middle and outer reagent positions on the outer ring area 122 of the reagent table, so that the reagent positions with different center distances are staggered and arranged on the reagent rack. On the other hand, different reagent positions correspond to different radiation directions, which can make full use of the accommodating space of the reagent rack and arrange more reagent positions, thereby increasing the reagent carrying capacity of the reagent table.

Each reagent position is correspondingly provided with a unique position identifier, and the scanning device 11 can identify the unique position identifier of each reagent position by scanning. The unique location identifier may be a two-dimensional code or a barcode, and the form of the unique location identifier is not limited here.

As shown in FIG. 1 , the reagent table may be disc-shaped, the inner area may be circular, and the outer ring area may be annular. The present invention does not limit the shapes of the reagent table, inner area and outer ring area.

In an embodiment of the present invention, a sample analyzer is provided, including a scanning device, a plurality of reagent racks, and a rotatable reagent table, the reagent table is divided into an inner area and an outer ring area, and the outer ring area surrounds the an inner area; the plurality of reagent racks are radially arranged on the outer ring area around the center of the inner area; each reagent rack is provided with a plurality of reagent positions for placing reagent containers; The sample analyzer only needs to control the movement of the reagent position on the outer ring area to the scanning device, so as to realize the identification of all the reagent containers on the reagent table, and does not need to reserve scanning on the outer ring area In order to control the movement of the scanning gap to the scanning device, it also controls the movement of the reagent bit on the inner region to the scanning gap, thereby reducing the complexity of the sample analyzer controlling the scanning process.

An embodiment of the present invention provides another sample analyzer. FIG. 2A is a schematic structural diagram of another sample analyzer according to an embodiment of the present invention. As shown in FIG. 2A , the sample analyzer 20 includes a scanning device 21 , which is rotatable. A disc-shaped reagent table 22 and a plurality of reagent racks 24 to 2N.

The reagent table 22 is divided into a circular inner area 221 and a circular outer ring area 222 , and the outer ring area 222 surrounds the inner area 221 .

The plurality of reagent racks 24 to 2N are radially arranged on the outer ring region 222 around the center 2211 of the inner region 221 , and the inner region 221 is not provided with reagent racks or reagent positions.

Each reagent rack is provided with at least one sub-area; in this embodiment, in the rotation direction of the reagent table 22 or the opposite direction of the rotation direction, each reagent rack is sequentially provided with two sub-areas. For example, taking the reagent rack 24 as an example, in the rotation direction of the reagent table 22 or the reverse direction of the rotation direction, as shown in FIG. 2A , the reagent rack 24 is sequentially provided with two sub-regions, which are the first Sub-region 241 and second sub-region 242 .

Each sub-area may have multiple reagent positions, for example, four reagent positions are set on each sub-area. Taking the first sub-area 241 as an example, in the rotation direction of the reagent table 22 or the opposite direction of the rotation direction , which are respectively the first reagent position, the second reagent position, the third reagent position and the fourth reagent position, for example, as shown in FIG. The first sub-area 241 includes a first reagent position 2411 , a second reagent position 2412 , a third reagent position 2413 and a fourth reagent position 2414 in sequence.

As shown in FIG. 2A , each reagent position on each sub-area surrounds the center 2211 of the inner area 221 and is staggered on the reagent racks 24 to 2N; each reagent position is arranged in the inner area 221 The center 2211 is the radiation direction of the radiation center, and different reagent positions correspond to different radiation directions. For example, taking the reagent rack 27 as an example, as shown in FIG. 2A , in the rotation direction of the reagent table 22 (eg, clockwise) Above, the reagent position 271 corresponds to the radiation direction 2212, the reagent position 272 corresponds to the radiation direction 2213, the reagent position 273 corresponds to the radiation direction 2214, the reagent position 274 corresponds to the radiation direction 2215, the reagent position 275 corresponds to the radiation direction 2216, and the reagent position 276 corresponds to the radiation direction 2215. Corresponding to the radiation direction 2217, the reagent position 277 corresponds to the radiation direction 2218, and the reagent position 278 corresponds to the radiation direction 2219; each reagent position is provided with a scanning port 23 toward the radiation direction, so that the scanning device 21 can scan Identify the reagent container on the reagent position.

Taking the distance between the reagent position and the center 2211 of the inner area 221 as the center distance, each reagent rack is provided with three kinds of reagent positions with different center distances; the first sub-area 241 of the reagent rack 24 is still For example, as shown in FIG. 2B , the first reagent position 2411 and the third reagent position 2413 have the same center distance, and the center distance of the first reagent position 2411 is greater than the center distance of the second reagent position 2412 , the center distance of the second reagent position 2412 is greater than the center distance of the fourth reagent position 2414 .

Each reagent position is correspondingly provided with a unique position identification, and the scanning device can identify the unique position identification of each reagent position by scanning. The unique location identifier may be a two-dimensional code or a barcode, and the form of the unique location identifier is not limited here.

An embodiment of the present invention provides yet another sample analyzer. FIG. 3A is a schematic structural diagram of another sample analyzer according to an embodiment of the present invention. As shown in FIG. 3A , the sample analyzer 30 includes a scanning device 31 , which is rotatable. The disc-shaped reagent table 32 and a plurality of reagent racks 34 to 3N.

The reagent table 32 is divided into a circular inner area 321 and a circular outer ring area 322 , and the outer ring area 322 surrounds the inner area 32 .

The plurality of reagent racks 34 to 3N are reagent racks of the same structure, and are arranged on the outer ring area 322 at equal intervals. For example, they are radially arranged around the center 3211 of the inner area 321 at equal intervals. on the outer ring area 322; in this way, when the plurality of reagent racks with the same structure are arranged at equal intervals on the outer ring area 322, two adjacent reagent racks can be closely connected, so that two adjacent reagent racks can be closely connected. The reagent positions are arranged more compactly between the reagent racks. Multiple reagent racks with the same structure can also lead to lower production costs. The inner area 321 is not provided with reagent racks or reagent positions.

Each reagent rack is provided with a plurality of reagent positions for placing reagent containers; in order to enable the reagent rack to place reagent containers of different capacities, each reagent rack is provided with at least two reagent positions with different sizes, and reagents of different sizes are provided with at least two reagent positions. For example, in the rotation direction of the reagent table or the opposite direction of the rotation direction, each reagent rack is provided with two kinds of reagent positions with different sizes, and the two kinds of reagent positions are staggered cloth; taking the reagent rack 34 as an example, as shown in FIG. 3A , the reagent rack 34 is provided with four reagent positions 341 to 344 having a first size, and four reagent positions having a second size 345 to reagent positions 348, the first size is greater than the second size, the reagent positions having the first size and the reagent positions having the second size are staggered.

The reagent positions surround the center 3211 of the inner area 321 and are staggered on the reagent rack; each reagent position is arranged in the radiation direction with the center of the inner area as the radiation center, and different reagent positions correspond to different In the radiation direction, each reagent position is provided with a scanning port 33 toward the radiation direction, so that the scanning device can identify the reagent container on the reagent position by scanning; The distance between the centers is the center distance, and each reagent rack is provided with at least two reagent positions with different center distances.

Each reagent position is correspondingly provided with a unique position identification, and the unique position identification can be set on one side of the scanning port of the corresponding reagent position; for example, taking the reagent rack 34 as an example, as shown in FIG. 3B , on the reagent table In the direction of rotation (for example, clockwise), the unique position identifier of the reagent position 341 is set at the side 3311 of the scanning port 331 corresponding to the reagent position 341, which is used to uniquely identify the position of the reagent position 341; the unique position of the reagent position 345 The position marker is set at one side 3321 of the scan port 332 corresponding to the reagent position 345, and is used to uniquely identify the position of the reagent position 345; in this way, when the unique position marker is set at one side of the scan port of the corresponding reagent position, The unique location identifier obtained by the scanning device and the unique reagent identifier on the reagent position corresponding to the unique location identifier (attached to the reagent container containing the reagent) are arranged at intervals. Taking scanning a single reagent rack as an example, the reagent rack The sequence of the unique location identifiers and the unique reagent identifiers on the reagent rack is shown in Figure 3C. The unique location identifiers on the reagent rack and their corresponding unique reagent identifiers are arranged at intervals. It is conceivable that when the scanning device 31 is turned on, The reagent table 32 rotates according to the rotation direction. Assuming that all the unique position identifications and reagent identifications can be accurately identified, the unique position identifications scanned by the scanning device 31 and the corresponding unique reagent identifications must be arranged at intervals, that is, in sequence. are the unique location identifier L1, the unique reagent identifier S1, the unique location identifier L2, the unique reagent identifier S2, ..., the unique location identifier L8, and the unique reagent identifier S8.

In the rotation direction of the reagent table or the reverse direction of the rotation direction, there is a sequential relationship between the unique position identifiers of the front and rear reagent positions in the same reagent rack; for example, each reagent rack has 8 reagent positions , 8 unique position identifiers are used to identify these 8 reagent positions, and it is assumed that the unique position identifier consists of 4-digit codes, wherein the first 2-digit codes are used to uniquely identify the corresponding reagent racks, and the last 2-digit codes are used to uniquely identify the reagent racks. If the corresponding reagent positions are identified, then taking the reagent rack 34 shown in FIG. 3A as an example, in the rotation direction of the reagent table (for example, in the clockwise direction), the eight reagent positions on the reagent rack 34 correspond to unique positions respectively. The identifiers are: 0101, 0102, 0103, 0104, 0105, 0106, 0107, 0108, or the unique location identifiers corresponding to the eight reagent positions on the reagent rack 34 are: 0101, 0103, 0105, 0107, 0109, 0111, 0113, 0115. That is to say, in the rotation direction of the reagent table or the reverse direction of the rotation direction, the unique position identifiers of the front and rear reagent positions in the same reagent rack only need to have a sequential relationship, for example, the equal intervals increase or the equal intervals decrease. Based on the above example, in the rotation direction of the reagent table, after scanning the reagent containers on the 8 reagent positions on the reagent rack 34, continue to scan the reagent containers on the 8 reagent positions on the reagent rack 35, the reagent rack 35 The unique position identifiers corresponding to the 8 reagent positions on the upper part are: 0201, 0202, 0203, 0204, 0205, 0206, 0207, 0208; .

The unique location identifier includes the unique identifier of the corresponding reagent rack; for example, the unique location identifier uses a 4-digit code, and the first two digits are used to uniquely identify the reagent rack on the reagent table, such as the outer ring area of the reagent table. 6 reagent racks have been selected, then, at this time, "01, 02, ..., 06" can be used to identify the corresponding reagent racks respectively.

Based on the above-mentioned setting features of the unique location identifier, in practical applications, when a unique location identifier cannot be identified, the unrecognizable unique location identifier can be determined by a preset error correction method, and the unique location identifier can be updated to scan in the obtained data.

Based on the foregoing embodiments, an embodiment of the present invention provides a reagent scanning method, which is applied to any of the sample analyzers described above. FIG. 4 is a schematic diagram of the implementation flow of a reagent scanning method according to an embodiment of the present invention, as shown in FIG. 4, the method includes steps S401 to S403:

S401. Determine the theoretical number and the actual number of reagent containers between the two unique position identifiers obtained by scanning;

S402, according to the theoretical number of the reagent containers and the actual number of the reagent containers, determine the unique location identifier that is missed between the two unique location identifiers before and after;

In other embodiments, if the theoretical number of the reagent containers is equal to the actual number of the reagent containers, and the theoretical number of the reagent containers is greater than 1, according to the coding method of the unique position identifier, it is determined that the The unique location identifiers that are missed between the two unique location identifiers. Understandably, if the theoretical number of the reagent containers is equal to the actual number of the reagent containers, it means that the unique reagent identifiers of all the reagent containers located between the two unique position identifiers before and after have been successfully identified. The theoretical number of reagent containers is greater than 1, indicating that there is a unique position identification that is missed between the two unique position identifications. Similarly, if the theoretical number of the reagent containers is equal to 1, it means that there are two unique position identifications between the two unique position identifications. There is no unique location identifier that is missed between the location identifiers; if the theoretical number of the reagent containers is greater than the actual number of the reagent containers, it means that there is a unique location identifier for the missed scan reagent container located between the two unique location identifiers. Reagent identification, at this time, the reagent table can be controlled to return to any position indicated by the front and rear unique position identifications, and then start to rotate, so that the scanning device can rescan the unique reagent identification of the missed reagent container.

S403. Insert the unique location identifier of the missed scan into a position corresponding to the unique location identifier of the missed scan between the two front and rear unique location identifiers.

In other embodiments, according to the scanning sequence, the missed unique location identifiers are sequentially inserted between two adjacent unique reagent identifiers between the two front and rear unique location identifiers. For example, according to the scanning order, the scanned data are: 0101, 029421, 059415, 038522, 0104. According to the length of each group of data, it can be determined: 0101 and 0104 are unique location identifiers, 029421, 059415, 038522 are unique reagent identifiers, Then, according to the unique location identifiers 0101 and 0104, it can be determined that the unique location identifiers of the missed scans are: 0102 and 0103. Therefore, according to the scanning sequence, insert the unique location identifiers of the missed scans into two adjacent unique reagent identifiers in sequence. After that, the new scan data obtained are: 0101, 029421, 0102, 059415, 0103, 038522, 0104.

In an embodiment of the present invention, a reagent scanning method is provided. The method determines the theoretical number and actual number of reagent containers between the two unique position identifiers before and after scanning, and determines the theoretical number and the actual number of reagent containers according to the theoretical number and The actual number of the reagent containers, determine the unique location identifier of the missed scan between the two unique location identifiers before and after, insert the unique location identifier of the missed scan between the two unique location identifiers before and after the two unique location identifiers. The unique location of the missed scan identifies the corresponding location. In this way, through the two unique location identifiers obtained by scanning, the correction of the missing unique location identifier is realized, thereby reducing the bit error rate of the scanning device during the scanning process, and solving the problem that the unique location identifier cannot be identified. The unique reagent identifier corresponds to the problem of the reagent position.

An embodiment of the present invention provides another reagent scanning method, which is applied to any of the above-mentioned sample analyzers. FIG. 5A is a schematic diagram of the implementation flow of another reagent scanning method according to an embodiment of the present invention, as shown in FIG. 5A . , the method includes steps S501 to S507:

S501, controlling a designated position on the reagent table to move to the scanning device;

Here, it should be noted that the designated position may be the default initial scanning position of the sample analyzer when the reagent table starts to be scanned, that is, the position corresponding to the scanning device after the reagent table is reset. Generally speaking, the designated position is the position uniquely identified by the unique position identifier, and in the rotation direction of the reagent table or the reverse direction of the rotation direction, the first unique position identifier on a reagent rack is identified. As the initial scanning position, for example, taking the sample analyzer shown in FIG. 2A as an example, the position 270 uniquely identified by the unique position identifier corresponding to the reagent position 271 is used as the initial scanning position. When the sample analyzer 20 starts to work, Control the position 270 on the reagent table to move to the scanning device; in addition, the designated position can also be the position currently set by the user. Generally speaking, the user can set the position to be scanned by inputting a unique position identifier For example, taking the reagent rack 34 shown in FIG. 3B on the sample analyzer as an example, assuming that the user inputs the unique position identifier pasted at the position 3311, the sample analyzer 30 can control the The position 3311 on the reagent table moves to the scanning device.

S502, start the scanning device;

It can be understood that after controlling the designated position of the reagent table to move to the scanning device (ie, step S501 ), the scanning device is started again, in order to avoid repeating the unique position identifier passing through the scanning device during the scanning movement. and unique reagent identification. Of course, in practical applications, the scanning device can also be started first, and then step S501 is executed, but during the period of controlling the movement of the specified position to the scanning device, the scanned data (ie the unique position identifier and the unique reagent identifier).

S503, controlling the reagent table to rotate from the designated position according to a preset rotation direction;

S504, acquiring the unique position identifier and the unique reagent identifier obtained by scanning during the preset rotation distance of the reagent table;

Here, it should be noted that the preset distance refers to the preset rotation distance of the reagent table. Generally speaking, the preset distance is the distance of a plurality of reagent racks, for example, the preset distance is one reagent Taking the sample analyzer 20 shown in FIG. 2A as an example, assuming that the designated position is the position 270, in the rotation direction, the reagent table is controlled to start to rotate, so that the reagent table is at the scanning device, from the position 270 When it is rotated to the position where the reagent position 278 is located, the rotation distance through which it passes is the distance of the one reagent rack.

S505. Determine the theoretical number and the actual number of reagent containers between any two unique position identifiers before and after the reagent table rotates a preset distance;

It can be understood that under ideal conditions, all the unique position identifiers on the reagent rack should theoretically be scanned by the scanning device. For example, in the rotation direction of the reagent table, under ideal conditions, scanning the reagent rack No. The unique position identification and the unique reagent identification should be: 0101, 8 (that is, the unique reagent identification on the 8th reagent position, similar to the subsequent), 0103, 4, 0105, 7, 0107, 2, 0109, 6, 0111, 3 , 0113, 5, 0115, 1; and in the actual scanning process, it is assumed that the unique location identifier 0103 cannot be recognized, that is, the unique location identifier and unique reagent identifier actually obtained by scanning the reagent rack No. 1 are: 0101, 8, 4 , 0105, 7, 0107, 2, 0109, 6, 0111, 3, 0113, 5, 0115, 1; therefore, it is easy to obtain that the theoretical number of reagent containers between the two unique position identifiers 0101 and 0105 is 2, The actual number of reagent containers between the front and rear two unique position identifiers 0101 and 0105 is 2 (ie, the unique reagent identifier on the No. 8 reagent position and the unique reagent identifier on the No. 4 reagent position).

S506, according to the theoretical number of the reagent containers and the actual number of the reagent containers, determine a unique location identifier that is missed between the two unique location identifiers before and after;

S507. Insert the unique location identifier of the missed scan into a position corresponding to the unique location identifier of the missed scan between the two front and rear unique location identifiers.

In other embodiments, for step S504, the obtaining of the unique position identifier and the unique reagent identifier scanned during the rotation of the reagent table by the preset distance, as shown in FIG. 5B, includes steps S5041 to S5042:

S5041. Determine whether the data between the two unique position identifiers before and after scanning obtained during the preset distance is empty; if so, execute step S5042; otherwise, return to execute step S5041;

Here, it should be noted that, in practical applications, it is determined whether the data between the two unique location identifiers before and after is empty, that is, it is determined whether there is data between the two unique location identifiers, and if not, it is empty. Or, it is determined whether the data between the two unique position identifiers before and after is a character used to characterize that the data is empty, for example, if the character is NULL, it means that the data is empty.

It should also be noted that, if the data between the two unique location identifiers before and after is not empty, when returning to step S5041, determine the distance between the next two unique location identifiers scanned during the preset distance. Whether the data is empty; for example, the unique position identification and the unique reagent identification on the No. 1 reagent rack are: 0101, 8 (that is, the unique reagent identification on the No. 8 reagent position, similar to the following), 0103, 4, Take 0105, 7, 0107, 2, 0109, 6, 0111, 3, 0113, 5, 0115, 1 as an example, if the data between the two unique position identifiers 0101 and 0103 before and after it is determined through step S5041 is not empty, return Execute step S5041, namely continue to determine whether the data between the next two unique position identifiers 0103 and 0105 is empty; and so on, whether the data between each front and back unique position identifiers scanned during the completion of the preset distance is whether Empty detection, thus ensuring a unique reagent identification for each reagent container during the preset distance.

S5042. Control the reagent table to return to the position of the reagent position between the front and rear unique position identifiers, so that the scanning device can rescan the reagent position on the reagent position between the front and rear two unique position identifiers. Unique reagent identification.

Understandably, if the data between the front and rear unique position identifiers scanned during the preset rotation of the reagent table is empty, it means that the two unique position identifiers scanned during the rotation of the reagent table are between the two unique position identifiers. If there are unidentified reagent containers in between, in this case, step S5042 can be executed to rescan the unidentified reagent containers.

It should also be noted that, in order to prevent the reagent table from returning to the position between the two unique position identifiers before and after, the scanning device repeatedly scans other obtained unique position identifiers and unique reagent identifiers. Before step S5042, the scanning device needs to be turned off first, and after the reagent table is controlled to return to the position between the front and rear unique position identifiers, the scanning device is turned on, so that the scanning device can be restarted. Scan the unidentified reagent container. Of course, the scanning device may not be turned off, but in the process of returning to the position between the two unique position identifications before and after, the unique position identification and the unique reagent identification that are repeatedly scanned are not stored.

In other embodiments, for step S504, the obtaining of the unique position identifier and the unique reagent identifier scanned during the rotation of the reagent table by the preset distance, as shown in FIG. 5C, includes steps S5044 to S5046:

S5044. When controlling the reagent table to rotate from the designated position according to the preset rotation direction, if the data scanned by the scanning device at the current moment is a unique position identifier, determine whether the data scanned at the next moment is Empty; if yes, go to step S5045; otherwise, go to step S5046. The reagent table can be rotated according to a certain rotation law, so after the unique position identifier is identified, normally if a reagent container is placed in this position, the unique reagent identifier of the reagent container will be scanned at the next moment. The next moment here is related to the law of rotation.

Here, in practical applications, the difference between the unique location identifier and the unique reagent identifier can be used as the basis for determining whether the data scanned at the current moment is the unique location identifier. For example, the length of the unique location identifier is generally 4 digits. , the length of the unique reagent identifier is generally 6 digits, so it can be determined whether the data scanned at the current moment is the unique location identifier or the unique reagent identifier according to the length of the scanned data. For another example, the first bit of the unique location identifier is generally 0, and the first bit of the unique reagent identifier is not 0. Therefore, it can be determined whether the current scanned data is the unique location identifier or the unique reagent identifier according to whether the first bit of the scanned data is 0.

S5045. Control the reagent table to return to the position of the reagent position where the data obtained by scanning is empty, so that the scanning device can re-identify the unique reagent identifier on the reagent position where the data obtained by scanning is empty by scanning, and return Step S5044 is executed.

Here, it should be noted that, different from the scanning method provided in FIG. 5B , the scanning method provided in FIG. 5C is a method of judging whether there is an unrecognized unique reagent identifier while scanning. Therefore, step S5045 is executed. Previously, there was no need to turn off the scanning unit.

S5046, controlling the reagent table to continue to rotate to the position corresponding to the next moment.

In other embodiments, in the rotation direction of the reagent table or the reverse direction of the rotation direction, there is a sequential relationship between the unique position identifiers of the front and rear reagent positions in the same reagent rack.

Barcode identification systems are widely used in medical instruments (such as sample analyzers), mainly to identify sample (reagent) information. Due to the constraints of the size of the whole medical instrument, the reagent racks are usually designed in a multi-layer structure, and there are usually two types of reagent racks, linear reagent racks and disk-shaped distribution reagent racks; among them, the typical reagent racks are disk-shaped distribution sample analyzers. The structure, as shown in Figure 6, is provided with a circle of reagent positions 611 on the inner ring area 61 of the reagent table, and two circles of reagent positions 621 are set on the outer area 62 of the reagent table, because the reagent containers on the outer area 62 are easily blocked. The reagent code on the reagent container on the inner ring area 61, therefore, in order to facilitate the barcode scanner (ie the scanning device) to scan the reagent code on the reagent container on the inner ring area, some two There is at least one large scanning gap 621 between the reagent racks, which not only makes the arrangement of reagent positions on the reagent rack with a multi-layer structure not compact, but also increases the difficulty of scanning the reagent positions on the inner ring area and the cost of production and assembly.

There are two common ways to scan barcodes: one is static scanning and the other is dynamic scanning. The static scanning method mainly relies on the position information of the coordinate positioning reagent, which requires high accuracy of the mechanical position and slow scanning speed. Dynamic scanning mainly relies on the position code to determine the position information of the reagent. Although the scanning speed is fast, the error rate is high. At present, most medical instruments adopt the static scanning method or the dynamic scanning method in which the position of the reagent is determined by a single position code, so the scanning speed is slow or the bit error rate is high.

Based on this, an embodiment of the present invention provides a multi-layer structure sample analyzer without a scanning gap, and the reagent positions are only arranged on the outer ring area, for example, three outer, middle and inner reagent positions are arranged on the same reagent rack in the outer area , and these reagent positions are staggered, so that when the reagent table is rotated to make the scanning device scan the barcode, it is only necessary to control the barcode on the external area to move to the scanning device, and there is no need to reserve scanning between two reagent racks. gap, and while controlling the scanning gap to move to the scanning device, the barcode in the inner ring area is controlled to move to the scanning gap, so as to realize the scanning of the barcode on the inner ring area, thereby reducing the difficulty of scanning and positioning the reagent table, making the The process of the sample analyzer controlling the rotation and positioning of the reagent table becomes simple and easy to control.

In the embodiment of the present invention, the sample analyzer has the following features in structure:

First, as shown in FIG. 2B of the above-mentioned embodiment, each reagent rack has reagent positions in the outer, middle and inner circles, that is, the reagent positions in the outer circle (for example, the first reagent position 2411, the third reagent position 2413), The reagent positions in the middle circle (for example, the second reagent position 2412 ) and the reagent positions in the inner circle (for example, the fourth reagent position 2414 ) are arranged on the same reagent rack.

Second, as shown in FIG. 3A , the same reagent racks are used on the reagent table, and are arranged on the reagent table at equal intervals.

Third, the reagent racks can be placed continuously, and two adjacent reagent racks are fitted with each other, that is, the head of the second reagent rack and the tail of the first reagent rack are just fitted.

Fourth, each reagent position corresponds to an opening for scanning, and the openings for scanning (ie, the scanning ports) of the reagent positions on the outer, middle and inner circles of each reagent rack are arranged at intervals.

Fifth, the position code (that is, the unique position identification) used to uniquely identify the reagent position on the reagent rack is pasted on both sides of the opening for scanning of the outer ring reagent position. For example, take the reagent rack 34 as an example, as shown in the figure. As shown in 3B, in the rotation direction of the reagent table (for example, in the clockwise direction), the position code of the reagent position 341 is set at the side 3311 of the scanning port 331 corresponding to the reagent position 341, which is used to uniquely identify the position of the reagent position 341. ; The position code of the reagent position 345 is set at one side 3321 of the scanning port 332 corresponding to the reagent position 345 to uniquely identify the position of the reagent position 345; in this way, the position code is set on both sides of the scanning port of the reagent position, because The reagent code (that is, the unique reagent identifier) is pasted on the reagent container on the reagent position, so the setting of the above position code can realize the spaced arrangement of the position code and the reagent code; wherein, the position code and the reagent code can be QR code or barcode, which is not limited here.

Sixth, the different reagent rack position codes include the identification codes of the reagent racks, which are used to identify the reagent rack numbers.

Based on the structure of the above-mentioned sample analyzer, an embodiment of the present invention provides a barcode scanning workflow for a single reagent rack. It is assumed that the position code of the reagent rack adopts a 4-digit barcode, the first 2 digits indicate the reagent rack number, and the last 2 digits indicate the single reagent rack. on the location number. As shown in Figure 7, after the barcode scanner is turned on, the reagent table rotates according to the preset rotation direction, the barcode scanner scans the position code and the reagent code in turn, and the reagent rack number in the position code is replaced by "*". Figure 3B, each reagent position is marked with the reagent position number, the barcode between the *01 and *02 position codes is the reagent code of the 8th reagent position (outer circle), and the barcode between the *02 and *03 position codes The barcode is the reagent code of reagent position No. 4 (middle circle). Among them, the No. 1 reagent position is determined by the *08 and *01 position codes of the next reagent rack.

An embodiment of the present invention provides a barcode scanning method for multiple reagent racks. In the scanning method, the reagent racks on the reagent table are rotated to the scanner position for scanning. As shown in FIG. 8 , the scanning method includes step S801 Go to step S812:

S801, the reagent table is reset;

S802, controlling the reagent table to move the position where the position code *01 of the reagent rack to be scanned is located to the barcode scanner;

S803, turn on the barcode scanner, so that the barcode scanner starts scanning;

S804, controlling the distance that the reagent table moves a reagent rack;

It should be noted that the distance of a reagent rack refers to the distance from the position where the position code *01 is located to the position where *08 is located, that is, in the rotation direction of the reagent rack, the first The distance from the position of the position code to the position of the last position code of this reagent rack.

S805, save the scanned data obtained by scanning;

S806. Determine whether there is a reagent rack to be scanned according to the scanning data; if so, return to step S804; otherwise, execute step S807;

S807, determine whether there is an unrecognized reagent code in the scan data; if so, go to step S808; otherwise, go to step S812;

Generally speaking, for step S807, it can be detected whether the data between the previous location code and the next location code in the scanned data is empty, and if it is empty, the previous location code and the next location are determined. If the reagent code between the codes is an unrecognized reagent code, then execute steps S708 to S811, and return to execute step S807, when returning to execute step S807, what is detected is the next position code and the next position code in the scanned data. Whether the data between a location code is empty. In this way, by detecting whether the data between the two position codes in the scanned data is empty one by one, it is determined whether there is an unrecognized reagent code in the scanned data, and through steps S808 to S811, rescan the unrecognized reagent code. The reagent code is updated to the scan data, thereby laying a foundation for the subsequent accurate determination of the missed scan location code.

S808, turn off the barcode scanner, and then enter step S809;

Understandably, the purpose of turning off the barcode scanner is to prevent the reagent table from repeatedly scanning the saved location code or reagent code when the reagent table is in motion.

S809, controlling the reagent table to move the position corresponding to the unrecognized reagent code to the barcode scanner;

Understandably, the position between the positions indicated by the two position codes before and after the unrecognized reagent code is the position corresponding to the unrecognized reagent code.

S810, turn on the barcode scanner, so that the barcode scanner can re-scan the unrecognized reagent code;

S811, updating the data obtained by rescanning the unidentified reagent code into the scanned data, and then returning to step S807;

Here, it should be noted that when returning to step S807, it is to determine whether there is an unrecognized reagent code in the updated scan data.

S812, turn off the barcode scanner, and then reset the reagent table.

Based on the above-mentioned barcode scanning method for multiple reagent racks, the embodiment of the present invention provides a reagent scanning method that misses scanning the position code, which aims to scan the scanned position code and the scanned position code when part of the position code cannot be recognized. The number of reagent codes is used to determine the location of the reagent container corresponding to the reagent code. Take the 0204 location code as an example, which is unrecognizable due to pollution or damage. As shown in Figure 9, the reagent scanning process includes steps S901 to S904:

S901, the data obtained by scanning the barcode scanner in sequence are 0203, 029421, 059415, and 0205;

S902, according to the barcode length, determine that the position code is 0203, 0205, and the reagent code is 029421, 059415;

S903, determine that the number of reagent codes scanned between the position code 0203 and the position code 0205 is 2;

S904, update the reagent code 029421 on the reagent position between the position codes 0203 and 0204, and update the reagent code 059415 on the reagent position between the position code 0204 and the position code 0205.

Here, it should be noted that the position code on the reagent rack has a total of 4 digits, of which the first two digits represent the reagent rack number, and the last two digits represent the position on a single reagent rack. When scanning multiple reagent rack barcodes, identify the currently scanned reagent rack number based on the first two digits.

In the embodiment corresponding to FIG. 9 , the most ideal barcodes scanned by the barcode scanner are: 0203, 029421, 0204, 059415, 0205, and the location codes and reagent codes are arranged in sequence at intervals. However, when the location code 0204 cannot be recognized, the information actually obtained by the barcode scanner is: 0203, 029421, 059415, 0205. According to the first two digits of the location code 0203, the reagent rack currently being scanned is No. 2 reagent rack, and then Then calculate the difference between the two position codes before and after, 0205-0203=2, so there should be two reagent codes between the two position codes, so according to the scanning order of the two reagent codes, 0203, 029421, 0204 , 059415, 0205 to save. Finally, the restoration of barcode data on the entire reagent rack is realized.

In the embodiment of the present invention, in the structure of the outer, middle and inner circles of reagent positions of the reagent table, the scanning gap is cancelled, the three circles of reagent positions are arranged in a staggered manner, and the position code is fully shared (that is, when the position code is not scanned) In this case, the position code corresponding to the reagent code can be uniquely determined by using the front and rear position codes obtained by scanning), the structure is compact, and because the reagent positions are only arranged in the outer area, that is, the reagent positions in the inner, middle and outer circles. Arranged on the same reagent rack, no reagent positions are arranged on the inner ring area, which not only reduces the complexity of the reagent table structure, but also reduces the complexity of controlling the reagent table to scan, and reduces the production cost.

Since the position codes are all pasted on the outermost side of the reagent rack, the position codes are most likely to be unidentifiable such as adhesion of condensed water, damage, etc. In the embodiment of the present invention, a single position code is not used to determine the position of the reagent position , but use two adjacent identifiable position codes to identify, calculate the number of reagent bits that should be between the two position codes, and compare with the number of reagent codes obtained by scanning, and update the reagent codes in sequence. in the right position. In this way, multiple position codes are used to jointly determine the reagent position, so that the sample analyzer has a strong error correction capability and reduces the bit error rate. In addition, the outer, middle and inner reagent positions are all arranged on the same reagent rack. In this way, when scanning barcodes, it is only necessary to control the position corresponding to the position code on the reagent rack in the outer area or the reagent positions to move to the barcode scanner. There is no need to reserve a scanning gap between some two reagent racks, let alone control the movement of the scanning gap to the scanning device, and control the barcode in the inner ring area to move to the scanning gap to realize the inner ring. The scanning of the barcode on the area reduces the difficulty of scanning and positioning the reagent table, and makes the process of controlling the rotation and positioning of the reagent table by the sample analyzer simple and easy to control.

It should be noted that, herein, the terms "comprising", "comprising" or any other variation thereof are intended to encompass non-exclusive inclusion, such that an article or device comprising a list of elements includes not only those elements, but also no Other elements expressly listed, or those inherent to the article or device are also included. Without further limitation, an element qualified by the phrase "comprising a..." does not preclude the presence of additional identical elements in the article or device that includes the element.

The above are only preferred embodiments of the present invention, and are not intended to limit the scope of the present invention. Any equivalent structural transformation made by using the contents of the description and drawings of the present invention, or directly or indirectly applied to other related technical fields, are the same. Included in the scope of patent protection of the present invention.

Claims (15)

1. A sample analyser comprising a scanning device, a plurality of reagent racks and a rotatable reagent table; wherein,

the reagent pad is divided into an inner zone and an outer ring zone, the outer ring zone surrounding the inner zone;

the plurality of reagent racks disposed radially on the outer annular zone around a center of the inner zone, the inner zone being free of reagent racks or reagent sites;

each reagent rack is provided with a plurality of reagent positions for placing reagent containers; the reagent sites surround the center of the inner area and are arranged on the reagent rack in a staggered mode; each reagent position is arranged in the radiation direction taking the center of the inner area as the radiation center, different reagent positions correspond to different radiation directions, and each reagent position is provided with a scanning port towards the radiation direction, so that the scanning device can identify a reagent container on the reagent position in a scanning mode; taking the distance between the reagent position and the center of the inner area as a central distance, and arranging at least two reagent positions with different central distances on each reagent rack; each reagent position is correspondingly provided with a unique position identification, and the scanning device can identify the unique position identification of each reagent position in a scanning mode.

2. The sample analyzer of claim 1, wherein each reagent rack has at least two reagent sites with different center distances disposed thereon, comprising:

each reagent rack is provided with three reagent positions with different center distances.

3. The sample analyzer of claim 2, wherein each reagent rack is provided with at least one sub-region, each sub-region having four reagent sites, a first reagent site, a second reagent site, a third reagent site and a fourth reagent site in sequence in the rotation direction of the reagent table or in the reverse direction of the rotation direction; wherein the first reagent site and the third reagent site have the same center distance.

4. The sample analyzer of claim 3, wherein the first reagent site has a center distance greater than a center distance of the second reagent site, and the second reagent site has a center distance greater than a center distance of the fourth reagent site.

5. The sample analyzer of claim 3, wherein each reagent rack is provided with two sub-areas in sequence in a direction of rotation of the reagent table or in a direction opposite to the direction of rotation.

6. The sample analyzer of claim 1 wherein each reagent rack is configured with at least two reagent sites of different sizes for holding reagent containers of different capacities.

7. The sample analyzer of claim 6, wherein in the direction of rotation of the reagent table or in a direction opposite to the direction of rotation, each reagent rack is provided with two reagent sites having different sizes, the two reagent sites being arranged in a staggered arrangement.

8. The sample analyzer of claim 1, wherein there is a sequential relationship between the unique position identifiers of two reagent sites in front and back of the same reagent rack in the direction of rotation of the reagent table or in the opposite direction of the direction of rotation.

9. The sample analyzer of claim 1, wherein the unique location identifier comprises a unique identifier of the corresponding reagent rack.

10. The sample analyzer of claim 1, wherein the unique location identifier is disposed on a side of the scan port of the corresponding reagent site.

11. The sample analyzer of claim 1, wherein the plurality of reagent racks are identically configured reagent racks, equally spaced on the outer annular region.

12. A reagent scanning method applied to the sample analyzer of any one of claims 1 to 11, the method comprising:

determining the theoretical number and the actual number of the reagent containers between the front unique position mark and the back unique position mark obtained by scanning;

determining the unique position identifier which is not scanned between the front unique position identifier and the back unique position identifier according to the theoretical number of the reagent containers and the actual number of the reagent containers;

and inserting the unique position identifier of the missed scanning into a position between the front and the back unique position identifiers corresponding to the unique position identifier of the missed scanning.

13. The method of claim 12, wherein determining the unique position identifier that is missed between the two unique position identifiers based on the theoretical number of reagent containers and the actual number of reagent containers comprises:

and if the theoretical number of the reagent containers is equal to the actual number of the reagent containers and the theoretical number of the reagent containers is more than 1, determining the unique position identifier which is not scanned between the front unique position identifier and the rear unique position identifier according to the coding mode of the unique position identifier.

14. The method of claim 12, wherein prior to said determining the theoretical and actual number of reagent containers between two unique location identifiers before and after the scan, the method further comprises:

controlling a designated position on the reagent table to move to the scanning device;

starting the scanning device;

controlling the reagent table to rotate from the designated position according to a preset rotating direction;

and acquiring a unique position identifier and a unique reagent identifier which are scanned during the rotation of the reagent table by a preset distance.

15. The method of claim 14, wherein the acquiring the unique position identifier and the unique reagent identifier scanned during the rotation of the reagent table by the preset distance comprises:

and if the data between the front and back unique position identifications scanned during the rotation of the reagent table by the preset distance is empty, controlling the reagent table to return to the position of the reagent position between the front and back unique position identifications again, so that the scanning device can rescan the unique reagent identification on the reagent position between the front and back unique position identifications.

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