CN111060706A - Immunochromatography detection module - Google Patents
Immunochromatography detection module Download PDFInfo
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- CN111060706A CN111060706A CN202010055045.4A CN202010055045A CN111060706A CN 111060706 A CN111060706 A CN 111060706A CN 202010055045 A CN202010055045 A CN 202010055045A CN 111060706 A CN111060706 A CN 111060706A
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- 238000001514 detection method Methods 0.000 title claims abstract description 86
- 238000003317 immunochromatography Methods 0.000 title claims abstract description 11
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 56
- 230000003287 optical effect Effects 0.000 claims abstract description 51
- 230000007246 mechanism Effects 0.000 claims description 23
- 238000012806 monitoring device Methods 0.000 claims description 5
- 238000003556 assay Methods 0.000 claims 3
- 230000000694 effects Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 description 9
- 238000012544 monitoring process Methods 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 230000008859 change Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000009471 action Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/031—Multipass arrangements
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00732—Identification of carriers, materials or components in automatic analysers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/026—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
- G01N2035/00099—Characterised by type of test elements
- G01N2035/00148—Test cards, e.g. Biomerieux or McDonnel multiwell test cards
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00732—Identification of carriers, materials or components in automatic analysers
- G01N2035/00821—Identification of carriers, materials or components in automatic analysers nature of coded information
- G01N2035/00831—Identification of carriers, materials or components in automatic analysers nature of coded information identification of the sample, e.g. patient identity, place of sampling
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0474—Details of actuating means for conveyors or pipettes
- G01N2035/0491—Position sensing, encoding; closed-loop control
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Abstract
The invention relates to the technical field of immunodetection, and provides an immunochromatography detection module, which comprises a driving module and an optical detection module; the optical detection module is positioned at the upper part of the driving module, the driving module drives the multi-channel reagent card to the lower part of the optical detection module, and the optical detection module moves longitudinally and transversely above the multi-channel reagent card, aligns to the channel of the multi-channel reagent card and performs optical detection. The invention adopts a full-automatic optical detection module to perform optical detection on the multi-channel reagent card, and adopts a tray unit to clamp and fix the multi-channel reagent cards with different widths. The problem of in the existing market, reagent card incompatibility that the producer of difference produced, an immunochromatography detects module is proposed, reaches to fix the centre gripping to the multichannel reagent card that the producer of difference made width is different to accomplish optical detection's technological effect.
Description
Technical Field
The application relates to the field of reagent card detection, in particular to an immunochromatography detection module.
Background
At present, in the detection field of reagent card, along with the improvement of biotechnology and market demand, the reagent card often adopts the multichannel card, deposits a plurality of detection channels in same card promptly, detects a plurality of channels simultaneously to improve the efficiency of detecting. And the thickness and the size of the existing reagent card are different, so that the existing detection module cannot be compatible with the reagent cards of all models in the detection process, and the detection process cannot be smoothly carried out.
However, no detection module for solving the technical problems is available in the market at present, so that the existing detection module cannot be applied to multi-channel reagent cards of all models, the efficiency of immunoassay is greatly limited, the detection cost is increased, and the reliability and stability of detection results are affected.
Disclosure of Invention
The invention aims to solve the problems that a detection module is not provided for a multi-channel reagent card in the prior art, and the multi-channel reagent card cannot be normally fixed by the detection module due to different widths of the multi-channel reagent card.
In order to solve the above technical problems, the present invention provides an immunochromatography detection module comprising: comprises a driving module and an optical detection module; the optical detection module is located the upper portion of drive module, and the drive module drives multichannel reagent card to the below of optical detection module, and the optical detection module carries out vertically and horizontal removal in the top of multichannel reagent card, aligns the passageway of multichannel reagent card and carries out optical detection.
Specifically, the number of channels of the multi-channel reagent card is more than two.
Specifically, the multichannel reagent card needs to be reacted in the incubation module before optical detection, the multichannel reagent card is driven to a proper position by the driving module after the reaction is completed, and then the optical detection module realizes the optical detection of the multichannel reagent card through longitudinal and transverse movement.
The drive module comprises a tray unit, the tray unit is installed on the drive module, and different tray units are replaced according to the width of the multi-channel reagent card so as to realize fixed clamping of the multi-channel reagent card.
Specifically, the width of the multi-channel reagent card can be changed according to the difference of the number of channels, and the more the number of channels is, the wider the reagent card is; the smaller the number of channels, the narrower the reagent card.
Specifically, the tray base is installed below the tray unit to fix the tray unit, and the tray unit and the tray base can move together under the action of the driving module.
Specifically, the user selects the tray unit matched with the multi-channel reagent card according to the width of the multi-channel reagent card to match, so that the multi-channel reagent card is fixedly clamped by the tray unit.
The optical detection module comprises a longitudinal mechanism, a transverse mechanism and an optical detection unit; a transverse mechanism is arranged on the longitudinal mechanism, and an optical detection instrument is arranged on the transverse mechanism; the longitudinal mechanism drives the transverse mechanism to move in the longitudinal direction, and the transverse mechanism drives the optical detection instrument to move in the transverse direction.
The longitudinal mechanism comprises a longitudinal driving motor, a longitudinal supporting seat and a longitudinal guide rail, the longitudinal driving motor and the longitudinal supporting seat are installed on the longitudinal guide rail, the longitudinal driving motor drives the longitudinal supporting seat to longitudinally move on the longitudinal guide rail, and the transverse mechanism is fixed on the longitudinal supporting seat.
The transverse mechanism comprises a transverse driving motor, a transverse supporting seat and a transverse guide rail, the transverse driving motor and the transverse supporting seat are installed on the transverse guide rail, and the transverse driving motor drives the transverse supporting seat to move on the transverse guide rail. An optical detection instrument is fixed on the transverse supporting seat, and the transverse driving motor drives the optical detection instrument to transversely move on the transverse guide rail.
The driving module comprises a motor and a tray guide rail, and the motor drives the tray base to move on the tray guide rail. The immunochromatography detection module further comprises a monitoring device, and the monitoring device is used for monitoring the position change of the multi-channel reagent card.
Specifically, the monitoring method may be an image monitoring method, an infrared monitoring method, a position monitoring method, or a two-dimensional code scanning method.
The invention has the following beneficial effects: the full-automatic optical detection module is adopted to perform optical detection on the multi-channel reagent card, and the tray unit is adopted to clamp and fix the multi-channel reagent cards with different widths. The optical detection device solves the defects that the existing optical detection device for the multi-channel reagent card is not intelligent, low in efficiency and precision, cannot clamp and fix the multi-channel reagent cards with different widths, and detection results are easy to make mistakes.
Drawings
FIG. 1 is a schematic diagram of a driving module and an optical detection module of an immunochromatography detection module according to an embodiment;
FIG. 2 is a schematic diagram of an immunochromatographic detection module according to an embodiment;
FIG. 3 is a schematic structural diagram of a driving module of the immunochromatographic detection module according to an embodiment;
FIG. 4 is a schematic structural diagram of an optical detection module of the immunochromatographic detection module according to an embodiment.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention.
Furthermore, in the description of the present invention, unless otherwise expressly specified or limited, the terms "mounted," "connected," and the like are to be construed broadly and can include, for example, fixed connections, removable connections, or integral connections; can be mechanically or electrically connected; the two elements may be directly connected or indirectly connected through an intermediate medium, or may be communicated with each other inside the two elements, or may be wirelessly connected or wired connected. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
Furthermore, the technical features mentioned in the different embodiments of the invention described later can be combined with each other as long as they do not conflict with each other.
Example (b):
referring to fig. 1, the present invention provides a technical solution: an immunochromatography detection module is provided, wherein a driving module 9 and an optical detection module 8 are arranged on a supporting vertical plate 16. After the five-channel reagent card 10 is reacted, the five-channel reagent card enters the immunochromatography detection module, the five-channel reagent card 10 is placed into the reagent card tray unit 2 matched with the width of the five-channel reagent card, the driving motor 3 drives the reagent card tray unit 2 and the reagent card 10 to move on the guide rail 11 together, and in the moving process, the reagent card monitoring device 6 monitors the position change of the five-channel reagent card 10 by scanning the two-dimensional code on the five-channel reagent card 10. When the five-channel reagent card 10 is detected to enter the optical detection module 8, the optical detection instrument 5 starts detection.
In the detection process, a longitudinal screw motor 7 on a longitudinal mechanism of an optical detection module 8 is firstly driven to adjust the length of a longitudinal screw 12 to control the optical detection instrument 5 to move longitudinally along a longitudinal guide rail 13, so that the optical detection instrument 5 reaches a detection area of a five-channel reagent card 10, then a transverse screw driving motor 4 is driven to adjust the length of a transverse screw 15 to drive the optical detection instrument 5 to move transversely on a transverse guide rail 14, finally, the optical detection instrument 5 reaches the position above one channel of the five-channel reagent card 10 to be detected, and after the detection is finished, the optical detection instrument 10 is sequentially adjusted to move transversely to detect the rest channels.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principles of the present invention are intended to be included within the scope of the present invention.
Claims (9)
1. An immunochromatography detection module, comprising: the optical detection module comprises a driving module and an optical detection module; the optical detection module is positioned at the upper part of the driving module, and the driving module drives the multi-channel reagent card to the lower part of the optical detection module for optical detection; the drive module comprises a tray unit, the tray unit is installed on the drive module, and different tray units are replaced according to the width of the multi-channel reagent card so as to realize the fixed clamping of the multi-channel reagent card by the tray unit.
2. The immunochromatographic assay module of claim 1, wherein the multi-channel reagent card is stationary and the optical assay module moves longitudinally and laterally over the multi-channel reagent card to align the channels of the multi-channel reagent card for optical assay.
3. The immunochromatographic detection module of claim 1, wherein the optical detection module comprises a longitudinal mechanism, a transverse mechanism and an optical detection unit;
the transverse mechanism is arranged on the longitudinal mechanism, and the optical detection unit is arranged on the transverse mechanism;
the longitudinal mechanism drives the transverse mechanism to move in the longitudinal direction, and the transverse mechanism drives the optical detection unit to move in the transverse direction.
4. The immunochromatographic detection module of claim 3, wherein the longitudinal mechanism comprises a longitudinal driving motor, a longitudinal support, and a longitudinal guide, the longitudinal driving motor and the longitudinal support are mounted on the longitudinal guide, the longitudinal driving motor drives the longitudinal support to move longitudinally on the longitudinal guide, and the longitudinal support fixes the transverse mechanism thereon.
5. The immunochromatographic detection module of claim 3, wherein the transverse mechanism comprises a transverse driving motor, a transverse support and a transverse guide rail, the transverse driving motor and the transverse support are mounted on the transverse guide rail, and the transverse driving motor drives the transverse support to move on the transverse guide rail.
6. The immunochromatographic detection module of claim 7, wherein the optical detection unit is fixed on the transverse support, and the transverse driving motor drives the optical detection instrument to move transversely on the transverse guide rail.
7. The immunochromatographic detection module of claim 2, wherein the driving module comprises a tray base which is mounted on the lower portion of the tray unit to fix the tray unit.
8. The immunochromatographic detection module of claim 7, wherein the drive module comprises a motor and a tray guide, the motor driving the tray base to move on the tray guide.
9. The immunochromatographic detection module of claim 2, comprising a monitoring device mounted on the optical detection module, the monitoring device being used to monitor whether the multi-channel reagent card is placed in the tray unit.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010055045.4A CN111060706A (en) | 2020-01-17 | 2020-01-17 | Immunochromatography detection module |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010055045.4A CN111060706A (en) | 2020-01-17 | 2020-01-17 | Immunochromatography detection module |
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| CN111060706A true CN111060706A (en) | 2020-04-24 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111624331A (en) * | 2020-05-22 | 2020-09-04 | 军事科学院系统工程研究院卫勤保障技术研究所 | Multichannel synchronous fluorescence immunochromatography detection system |
| CN113311158A (en) * | 2021-06-04 | 2021-08-27 | 浙江恩谱生物科技有限公司 | Multichannel colloidal gold immunoassay appearance |
| CN113340809A (en) * | 2021-04-23 | 2021-09-03 | 广州万孚倍特生物技术有限公司 | Image acquisition device and method |
| CN114965995A (en) * | 2022-05-20 | 2022-08-30 | 北京与子成科技有限公司 | Immunochromatography analysis detection system and method |
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| CN113340809A (en) * | 2021-04-23 | 2021-09-03 | 广州万孚倍特生物技术有限公司 | Image acquisition device and method |
| CN113311158A (en) * | 2021-06-04 | 2021-08-27 | 浙江恩谱生物科技有限公司 | Multichannel colloidal gold immunoassay appearance |
| CN114965995A (en) * | 2022-05-20 | 2022-08-30 | 北京与子成科技有限公司 | Immunochromatography analysis detection system and method |
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Application publication date: 20200424 |