CN110801581B - A human brain light stimulation control device - Google Patents
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Abstract
本发明涉及一种人脑光刺激调控装置，包括：依次连接的光参数调控模块、光产生模块、光照射探头和探头位置调整模块；光参数调控模块与光产生模块连接，用于设定光产生模块产生光信号的光强、波长和照射时间；光产生模块产生预定光强和频率的光信号，并将光信号传输至光照射探头；光照射探头的照射面积能够根据不同照射模式进行调整，用于对脑的特定疾病对应的区域实施定点照射；探头位置调整模块与光照射探头连接，用于调整和锁定光照射探头的照射位置。本发明通过向人脑的特定部位输入光信号，增加人脑内部ATP，增强人脑活性，提高人脑的认知能力，对抑郁症、自闭症、阿尔兹海默症、帕金森症和癫痫症等疾病具有一定辅助治疗的作用。
The invention relates to a human brain light stimulation control device, comprising: a light parameter control module, a light generation module, a light irradiation probe and a probe position adjustment module connected in sequence; the light parameter control module is connected with the light generation module and is used for setting the light The light generating module generates the light intensity, wavelength and irradiation time of the light signal; the light generating module generates the light signal with a predetermined light intensity and frequency, and transmits the light signal to the light irradiation probe; the irradiation area of the light irradiation probe can be adjusted according to different irradiation modes , which is used to perform fixed-point irradiation on the area corresponding to a specific disease of the brain; the probe position adjustment module is connected with the light irradiation probe to adjust and lock the irradiation position of the light irradiation probe. The present invention increases the ATP in the human brain, enhances the activity of the human brain, and improves the cognitive ability of the human brain by inputting light signals to a specific part of the human brain, and is effective for depression, autism, Alzheimer's disease, Parkinson's disease and other diseases. Epilepsy and other diseases have a certain role in adjuvant therapy.
Description
Technical Field
The invention relates to a human brain light stimulation regulation and control device, belonging to the field of medical equipment.
Background
Cranial nerve regulation is an emerging method for improving the symptoms and quality of life of patients. At present, the more common brain nerve regulation method mainly comprises the following steps: transcranial Electrical Stimulation (TES) and Transcranial Magnetic Stimulation (TMS). The working principle is that the electrical signal or the magnetic signal is input into the brain to cause the activity potential of the neuron in the brain to change, thereby achieving the purpose of treating and improving the cognitive ability of the patient. Studies have shown that TES can play a role in improving cognitive abilities of patients such as motor control, short-term memory, problem solving and decision making; TMS can improve the cognitive ability of patients with depression, autism, Alzheimer's disease, Parkinson's disease, epilepsy and the like. However, TES adopts an electric signal stimulation mode, and if the electric signal parameters are not properly selected, the user is easy to cause discomfort reactions such as dizziness, nausea, headache and the like; the TMS device is bulky, expensive, and dangerous once it is not operated properly because it needs to generate a controllable magnetic field. Therefore, there is an urgent need for a cranial nerve regulation device with safety and reliability.
Because the intensity, the frequency and the irradiation range of the optical signal have higher adjustability, the light signal stimulation is a safer and more reliable cranial nerve regulation scheme at present. However, the optical signal stimulation schemes in the prior art generally stimulate the whole human brain, macroscopically and conceptually strengthen the brain, and improve the cognitive ability of the human, but lack a cranial nerve regulation and control device which can directionally stimulate cranial nerves aiming at specific brain diseases so as to improve specific symptoms of patients.
Disclosure of Invention
In view of the above-mentioned deficiencies of the prior art, the present invention provides a human brain light stimulation control device, which can increase Adenosine Triphosphate (ATP) in the human brain by inputting light signals to a specific part of the human brain, thereby enhancing the activity of the human brain, improving the cognitive ability of the human brain, and having a certain adjuvant therapy effect on diseases such as depression, autism, alzheimer's disease, parkinson's disease, epilepsy, etc.
In order to achieve the above object, the present invention provides a human brain light stimulation regulation device, comprising: the device comprises an optical parameter regulating module, a light generating module, a light irradiation probe and a probe position adjusting module which are connected in sequence; the optical parameter regulation and control module is connected with the light generation module and is used for setting the light intensity, the wavelength and the irradiation time of the light signal generated by the light generation module; the light generation module generates light signals with preset light intensity and frequency, and transmits the light signals to the light irradiation probe, and the preset light intensity and frequency are determined by different irradiation modes; the irradiation area of the light irradiation probe is determined by different irradiation modes and is changed along with the change of the irradiation modes, and the light irradiation probe is used for carrying out fixed-point irradiation on the area corresponding to the specific disease of the brain; the probe position adjusting module is connected with the light irradiation probe and used for adjusting and locking the irradiation position of the light irradiation probe.
Further, different irradiation patterns correspond to different brain diseases, and the corresponding brain diseases are treated or prevented by light stimulation.
Further, the irradiation mode includes: the first mode is as follows: the wavelength of the light source is 810nm, the power is 1400mW, and the irradiation area is 0.196cm2(ii) a And a second mode: the wavelength of the light source is 870nm, the power is set to be 550mW, and the irradiation area is 22cm2(ii) a And a third mode: the wavelength of a light source is 810nm, the power is 550mW, and the irradiation area is 14cm2(ii) a And a fourth mode: the light source wavelength is 810nm, and the power density is 700mW/cm2(ii) a The mode is none: the light source wavelength is 1064nm, and the power density is 250mW/cm2(ii) a Mode six: the light source wavelength is 1064nm, and the power density is 250mW/cm2。
Further, mode one is for stroke treatment; mode two for traumatic brain injury patients; mode three is for patients with alzheimer's disease; mode four for depression; mode five is used to improve mood; mode six is for preventing neuropsychological disorders.
Further, for stroke patients, traumatic brain injury patients, alzheimer patients, parkinson patients and mental disorder patients, the skin of the head corresponding to the frontal lobe area is stimulated; for patients with somatosensory impairment, stimulating the skin of the head corresponding to the apical lobe area; for patients with hearing impairment, the temporal lobe area is stimulated to correspond to the head skin; for patients with visual impairment, the skin of the head corresponding to the occipital lobe area is stimulated.
Further, the device also comprises a fixing module, wherein the fixing module is used for fixing and bearing the light irradiation probe and the probe position adjusting module.
Furthermore, the fixing device is respectively provided with an opening at the head skin position corresponding to the frontal lobe region, the head skin position corresponding to the parietal lobe region, the head skin position corresponding to the temporal lobe region and the head skin position corresponding to the occipital lobe region, the light irradiation probes are placed in the openings, and the probe position adjusting module determines the opening and closing of each light irradiation probe according to the type of the disease suffered by the patient.
Furthermore, the fixing device is provided with an opening at the head skin position corresponding to the frontal lobe area, the head skin position corresponding to the parietal lobe area, the head skin position corresponding to the temporal lobe area and the head skin position corresponding to the occipital lobe area, the probe position adjusting module comprises a transmission part, and the transmission part is used for transmitting the light irradiation probe to a designated position and putting the light irradiation probe into the corresponding opening.
Further, a light transmission module is arranged between the light generation module and the light irradiation probe and is used for transmitting the light signals generated by the light generation module to the light irradiation probe.
Due to the adoption of the technical scheme, the invention has the following advantages: the light signal is input to a specific part of the human brain, so that ATP in the human brain is increased, the activity of the human brain is enhanced, the cognitive ability of the human brain is improved, and the light signal has certain adjuvant therapy effect on diseases such as depression, autism, Alzheimer's disease, Parkinson's disease, epilepsy and the like. The irradiation position, the irradiation light intensity, the light wavelength and the light irradiation area can be automatically adjusted according to diseases of different patients, so that the light stimulation is more targeted, and a researcher can conveniently perform qualitative analysis on the light stimulation, thereby determining the degree to which the light signal can regulate and control the cranial nerves.
Drawings
FIG. 1 is a schematic structural diagram of a brain light stimulation control device according to an embodiment of the present invention;
FIG. 2 is a side view of an exemplary placement sequence of the International 10-20 electroencephalogram profile in accordance with one embodiment of the present invention;
FIG. 3 is a schematic view of the top of the head with the placement sequence of the International 10-20 electroencephalogram profile in one embodiment of the present invention.
Detailed Description
The present invention is described in detail by way of specific embodiments in order to better understand the technical direction of the present invention for those skilled in the art. It should be understood, however, that the detailed description is provided for a better understanding of the invention only and that they should not be taken as limiting the invention. In describing the present invention, it is to be understood that the terminology used is for the purpose of description only and is not intended to be indicative or implied of relative importance.
The present embodiment provides a human brain light stimulation modulation device, as shown in fig. 1, including: the device comprises an optical parameter regulating module, a light generating module, a light irradiation probe and a probe position adjusting module which are connected in sequence; the optical parameter regulation and control module is connected with the light generation module and is used for setting the light intensity, the wavelength and the irradiation time of the light signal generated by the light generation module; the light generation module generates light signals with preset light intensity and frequency, and transmits the light signals to the light irradiation probe, and the preset light intensity and frequency are determined by different irradiation modes; the irradiation area of the light irradiation probe is determined by different irradiation modes and is changed along with the change of the irradiation modes, and the light irradiation probe is used for carrying out fixed-point irradiation on the area corresponding to the specific disease of the brain; the probe position adjusting module is connected with the light irradiation probe and used for adjusting and locking the irradiation position of the light irradiation probe. In the embodiment, the light signals are input to the specific part of the human brain, so that ATP in the human brain is increased, the activity of the human brain is enhanced, the cognitive ability of the human brain is improved, a certain adjuvant therapy effect on diseases such as depression, autism, Alzheimer's disease, Parkinson's disease, epilepsy and the like is achieved, and meanwhile, the improvement of the cognitive ability of the brain is facilitated.
The reason why the photostimulation device in this embodiment can relieve the brain diseases and improve the cognitive ability is because the Cytochrome C Oxidase (CCO) in the human brain absorbs photons. Cytochrome c oxidase is located at the end of the cytochrome system in cellular respiration, and this enzyme transfers the electrons of the respiratory substrate directly to molecular oxygen via the cytochrome system. The light emitted from the light emitting module passes through a series of layers such as the scalp, periosteum, skull, meninges and dura mater, and finally reaches the surface of the human cerebral cortex, and is absorbed by the CCO. CCO plays a key role in brain metabolism, and the higher its activity, the higher the oxygen consumption and metabolic capacity of mitochondria. ATP, which is a high-energy compound in organisms, is mainly produced by mitochondria, is usually present inside cells, and serves as an energy currency molecule to support various metabolic activities of cells. Mitochondria are the most prominent source of intracellular ATP, determining ATP levels. Therefore, the increase of oxygen consumption and metabolism of mitochondria can lead to increase of ATP in cells, thereby promoting the growth and development of human brain cells, and the increase of ATP at a certain level can stimulate free Ca in cells2+Increase in molecular content of Nitric Oxide (NO), Reactive Oxygen Species (ROS), etc. Wherein NO binds to CCO to inhibit CCO activity and reduce ATP production. The light signal absorbed by the CCO can increase ATP yield by separating NO, thereby preventing NO from binding to CCO. Therefore, the light stimulation can relax blood vessels of the brain, increase blood circulation, promote cerebral neuroprotection and enhance cerebral cognitive function.
In order to facilitate the fixation of the light irradiation probe, the cerebral light stimulation control device in this embodiment further includes a fixing module, and the fixing module is used for fixing and bearing the light irradiation probe and the probe position adjusting module. The fixing module can only fix one light irradiation probe and one probe position adjusting module, and can also bear a plurality of light irradiation probes and each probe position adjusting module. Wherein the light irradiation probe may be movable or fixed. And the number of the light irradiation probes can correspond to the number of the probe position adjusting modules, or only one probe adjusting module can be arranged, and the probe adjusting module can move the light irradiation probes to corresponding positions. Specifically, a light irradiation probe can be placed at each position needing irradiation, the light irradiation probe at the position needing irradiation is controlled to be turned on through the probe position adjusting module, and the light irradiation probe at the position needing no irradiation is turned off. Another implementation manner is to set the position adjustment module as a transmission part, where the transmission part may be any one commonly used component that can implement a transmission function, such as a manipulator, and one end of the transmission part is fixed with the light irradiation probe to transmit the light irradiation probe to a designated position. The fixed module sets up corresponding opening in the position that needs shine, and the transmission portion will be transmitted to the light irradiation probe of assigned position and put into the opening can. The fixing module can also adjust the positions of the light irradiation probe and the skin of the head of the user, the adjusting mode can be automatic or manual, the automatic fixing module comprises a temperature sensor arranged on the light irradiation probe, when the temperature of the skin of the head of the user is detected to be too high, the distance between the light irradiation probe and the skin of the head is increased, and the head skin of the user is prevented from being burnt. In addition, the stent may also include a plurality of comb-like racks for plucking the user's hair to better direct the light signal to the user's brain.
In this embodiment, the light generating module and the light irradiation probe may be directly connected to each other, or may be connected to each other through a light transmission module disposed therebetween, where the light transmission module may be an optical fiber or the like, and the light transmission module is configured to transmit the optical signal generated by the light generating module to the light irradiation probe. By adopting the former setting method, the loss of optical signals emitted by the light generation module is less, different light irradiation probes can irradiate light with different intensities and wavelengths, the functions are comprehensive, the selectivity is high, but the light generation module needs to be in one-to-one correspondence with the light irradiation probes, and when the number of the light irradiation probes is large, the device is complex. The latter arrangement introduces the optical transmission module, and one optical generation module can correspond to a plurality of light irradiation probes, so that the device structure is greatly simplified, but the wavelength and intensity of light generated by the same optical generation module are fixed, the adjustable variable is less, and the longer optical path can also increase the loss of light. The specific selection should be determined according to the specific application scenario and requirements.
The light generating module essentially comprises a laser emitter, for example a diode laser emitter, preferably a laser emitter with a relatively large wavelength range. The light signal for brain stimulation is mainly concentrated in the red and infrared light range, so the laser emitter is also preferably a laser emitter emitting in this range of laser wavelengths.
The position where the light irradiation probe is placed is also different for users with different diseases. As shown in FIGS. 2 and 3, the position where the light irradiation probe is placed is selected according to the placement sequence of the International 10-20 electroencephalogram distribution chart. The international 10-20 system electroencephalogram distribution diagram specifically comprises:
1. first, two base lines are determined on the surface of the scalp, wherein one base line is a front-back connecting line from the nasal root to the occipital tuberosity, the length of the base line is 100%, and the other base line is a left-right connecting line between the front fovea of the ears, and the length of the base line is 100%. The intersection of the two at the top of the head is the position of the Cz electrode.
2. FPz (midline of the frontal pole) 10% posteriorly from the nasion, Fz (midline of the frontal pole) 20% posteriorly from FPz, Cz (midline of the center) 20% posteriorly from Fz, Pz (midline of the apex) 20% posteriorly from Cz, and Oz (midline of the occipital) 20% posteriorly from Pz. The spacing between Oz and the occipital tuberosity is 10%.
3. The anterior foveal line is T3 (left medial temporal) 10% from the left anterior fovea, T3 is C3 (left medial), C3 is Cz (central midline) 20% to the right, Cz is C4 (right medial) 20% to the right, and C4 is T4 (right medial temporal) 20% to the right. The T4 distance from the anterior concavity of the right ear is 10%.
4. A connecting line from FPz through T3 to Oz is a left temporal connecting line, FP1 (left frontal pole) is 10% to the left from FPz, F7 (left anterior temporal) is 20% to the back along the left lateral side from FP1, F7 is T3 (left medial temporal) is 20% to the back along the left lateral side, T3 is T5 (left posterior temporal) is 20% to the back along the left lateral side, T5 is O1 (left occipital) is 20% to the back along the left lateral side, wherein T3 is an intersection point of the left temporal connecting line and the anterior foveal connecting line, and O1 is 10% from Oz. FPz is right temporal line through the line from T4 to Oz, FP2 (right frontal pole) 10% to the right from FPz, F8 (right anterior temporal) 20% to the back along the right lateral side from FP2, F8 is T4 (right medial temporal) 20% to the back along the right lateral side, T4 is T6 (right posterior temporal) 20% to the back along the right lateral side, T6 is O2 (right occipital) 20% to the back along the right lateral side, wherein T4 is the intersection of the right temporal line and the anterior fovea line, and O1 is 10% from Oz.
5. The line from FP1 to O1 is a left vector bypass line with a length of 100%, and the line from FP2 to O2 is a right vector bypass line with a length of 100%. From FP1, 20% backward is F3 (left forehead), 20% backward F3 is C3 (left center), 20% backward C3 is P3 (left top), 20% backward P3 is O1 (left pillow); from FP2, 20% backward is F4 (right forehead), 20% backward F4 is C4 (right center), 20% backward C4 is P4 (right top), and 20% backward P4 is O2 (right pillow).
As shown in fig. 2 and 3, for patients with different diseases, different positions of the patient's head need to be irradiated. For example: for patients with apoplexy, traumatic brain injury, Alzheimer's disease, Parkinson's disease, and mental disorder, the head skin corresponding to frontal lobe region can be stimulated, such as Fp1Dot, Fp2Dot, F3Dot, F4Dots, etc.; for patients with somatosensory impairment, the skin of the head corresponding to the apical lobe region may be stimulated, e.g. C3Dots, C4Dots, CZDots, etc.; for patients with hearing impairment, the head skin corresponding to the temporal lobe area may be stimulated, e.g. T3Dot, T4Dots, etc.; for patients with impaired vision, the head skin corresponding to the occipital lobe area may be stimulated, e.g. O1Dots, O2Dots, etc. E.g. on the fastening device Fp1Dot, Fp2Dot, F3Dot, F4Dots, C3Dots, C4Dots, CZDot, T3Dot, T4Dots, O1Dot and O2The positions of the points are respectively provided with an opening, the light irradiation probes are placed in the openings, the switch of the light irradiation probes at the corresponding positions is opened by the probe position adjusting module according to the diseases of the patient, the light irradiation probes at the corresponding positions are opened, and the light irradiation probes at other positions are closed and do not emit light. Or on a fixing device Fp1Dot, Fp2Dot, F3Dot, F4Dots, C3Dots, C4Dots, CZDot, T3Dot, T4Dots, O1Dot and O2The position of the point is respectively provided with an opening, the probe position adjusting module comprises a transmission part, and the transmission part is used for transmitting the light irradiation probe to a specified position and placing the light irradiation probe into the corresponding opening. The transmission part can be a mechanical arm, a transmission belt, a transmission chain or a sliding clamping groove and the like, and various devices capable of realizing transmission of the light irradiation probe can be used.
The wavelength, power density and area of light that illuminates the patient's head are also different for patients with different diseases. For stroke patients, the light source wavelength was set to 810nm and the power was set to 1400 mW; for the traumatic brain injury patient, the light source wavelength is set to 870nm, and the power is set to 550 mW; for patients with Alzheimer's disease, the light source wavelength was set to 810nm and the power was set to 550 mW; for depression patients, the light source wavelength was set at 810nm and the power density was set at 700mW/cm2(ii) a For patients in need of mood improvement, the light source wavelength is set to 1064nm, and the power density is set to 250mW/cm2(ii) a For patients in need of preventing neuropsychological disorder, the light source wavelength is set to 1064nm, and the power density is set to 250mW/cm2. For the stroke patient, the irradiation area of each light irradiation probe was set to 0.196cm2(ii) a For traumatic brain injury patients, the irradiation area of each light irradiation probe is set to 22cm2(ii) a For patients with Alzheimer's disease, the irradiation area of each light irradiation probe is set to 14cm2. Since patients with depression, mood improvement, and neuropsychological disorder prevention are mainly used to increase psychological factors such as mood or simply to prevent brain diseases, the requirements for irradiation range are not particularly strict, and those skilled in the art can adjust the irradiation area according to the specific conditions of the patients. But the irradiation area should not exceed the area of the head skin corresponding to the frontal lobe area.
The above embodiments are only for illustrating the present invention, and the structure, size, arrangement position and shape of each component can be changed, such as the appearance size, fixing manner, lead wire manner and geometric configuration after assembly of each component.
Claims (5)
1. A human brain light stimulation modulation device, comprising: the device comprises an optical parameter regulating module, a light generating module, a light irradiation probe and a probe position adjusting module which are connected in sequence;
the optical parameter regulation and control module is connected with the light generation module and is used for setting the light intensity, the wavelength and the irradiation time of the light signal generated by the light generation module;
the light generation module generates light signals with preset light intensity and frequency, and transmits the light signals to the light irradiation probe, the preset light intensity and frequency are determined by different irradiation modes, and the irradiation modes are respectively used for treating apoplexy, traumatic brain injury, Alzheimer's disease and depression, improving emotion and preventing neuropsychological disorder;
the irradiation area of the light irradiation probe is determined by different irradiation modes and is changed along with the change of the irradiation modes, and the light irradiation probe is used for carrying out fixed-point irradiation on the area corresponding to the specific disease of the brain;
the probe position adjusting module is connected with the light irradiation probe and used for adjusting and locking the irradiation position of the light irradiation probe;
different irradiation modes correspond to different brain diseases, and the corresponding brain diseases are treated or prevented through light stimulation;
the illumination mode includes: the first mode is as follows: the wavelength of the light source is 810nm, the power is 1400mW, and the irradiation area is 0.196cm2(ii) a And a second mode: the wavelength of the light source is 870nm, the power is set to be 550mW, and the irradiation area is 22cm2(ii) a And a third mode: the wavelength of a light source is 810nm, the power is 550mW, and the irradiation area is 14cm2(ii) a And a fourth mode: the light source wavelength is 810nm, and the power density is 700mW/cm2(ii) a And a fifth mode: the light source wavelength is 1064nm and the power is denseThe degree is 250mW/cm2(ii) a Mode six: the light source wavelength is 1064nm, and the power density is 250mW/cm2；
Mode one for stroke treatment; mode two for traumatic brain injury patients; mode three is for patients with alzheimer's disease; mode four for depression; mode five is used to improve mood; mode six is for preventing neuropsychological disorders;
stimulating the head skin corresponding to the frontal lobe area for stroke patients, traumatic brain injury patients, Alzheimer's disease patients, Parkinson's disease patients and mental disorder patients; for patients with somatosensory impairment, stimulating the skin of the head corresponding to the apical lobe area; for patients with hearing impairment, the temporal lobe area is stimulated to correspond to the head skin; for patients with visual impairment, the skin of the head corresponding to the occipital lobe area is stimulated.
2. The human brain light stimulation regulation device of claim 1, further comprising a fixation module for fixing and carrying the light irradiation probe and the probe position adjustment module.
3. The human brain light stimulation regulation device of claim 2, wherein the fixing module is provided with an opening at the head skin corresponding to the frontal lobe region, the head skin corresponding to the parietal lobe region, the head skin corresponding to the temporal lobe region and the head skin corresponding to the occipital lobe region, the light irradiation probes are placed in the openings, and the probe position adjustment module determines the on-off of each light irradiation probe according to the type of the disease suffered by the patient.
4. The human brain light stimulation regulation device of claim 2, wherein the fixing module is provided with an opening at a head skin corresponding to the frontal lobe region, a head skin corresponding to the parietal lobe region, a head skin corresponding to the temporal lobe region, and a head skin corresponding to the occipital lobe region, respectively, and the probe position adjustment module comprises a transmission part, and the transmission part is configured to transmit the light irradiation probe to a specific position and place the light irradiation probe in the corresponding opening.
5. The human brain light stimulation regulation device of claim 1, wherein a light transmission module is further disposed between the light generation module and the light irradiation probe, and the light transmission module is configured to transmit the light signal generated by the light generation module to the light irradiation probe.
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| CN111973181B (en) * | 2020-08-24 | 2023-12-08 | 中国科学院上海微系统与信息技术研究所 | Cortical brain electrode integrated with acquisition stimulation function and manufacturing method thereof |
| CN115105752B (en) * | 2022-06-30 | 2025-02-28 | 上海近则生物科技有限责任公司 | A dual-light source human brain photobiomodulation device based on near-infrared LED and laser |
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