CN110800757B - A kind of bactericidal composition containing picoxazole and chlorpyrifostrobin and application thereof - Google Patents
A kind of bactericidal composition containing picoxazole and chlorpyrifostrobin and application thereof Download PDFInfo
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- CN110800757B CN110800757B CN201810885746.3A CN201810885746A CN110800757B CN 110800757 B CN110800757 B CN 110800757B CN 201810885746 A CN201810885746 A CN 201810885746A CN 110800757 B CN110800757 B CN 110800757B
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- nitrapyrin
- bactericidal composition
- pyridinconazole
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- powdery mildew
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- 239000000203 mixture Substances 0.000 title claims abstract description 37
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 30
- 241000221785 Erysiphales Species 0.000 claims abstract description 13
- 241000221662 Sclerotinia Species 0.000 claims abstract description 11
- 240000008067 Cucumis sativus Species 0.000 claims abstract description 10
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 claims abstract description 10
- 235000006008 Brassica napus var napus Nutrition 0.000 claims abstract description 9
- 241000209140 Triticum Species 0.000 claims abstract description 9
- 235000021307 Triticum Nutrition 0.000 claims abstract description 9
- 239000004480 active ingredient Substances 0.000 claims abstract description 6
- 240000000385 Brassica napus var. napus Species 0.000 claims abstract 2
- DCUJJWWUNKIJPH-UHFFFAOYSA-N nitrapyrin Chemical compound ClC1=CC=CC(C(Cl)(Cl)Cl)=N1 DCUJJWWUNKIJPH-UHFFFAOYSA-N 0.000 claims description 17
- DHTJFQWHCVTNRY-OEMAIJDKSA-N pyrisoxazole Chemical compound C1([C@@]2(C)CC(ON2C)C=2C=CC(Cl)=CC=2)=CC=CN=C1 DHTJFQWHCVTNRY-OEMAIJDKSA-N 0.000 claims description 16
- 238000009472 formulation Methods 0.000 claims description 8
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- 239000002671 adjuvant Substances 0.000 claims 1
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- 201000010099 disease Diseases 0.000 abstract description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 11
- 230000002195 synergetic effect Effects 0.000 abstract description 9
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- 239000003814 drug Substances 0.000 description 20
- 238000012360 testing method Methods 0.000 description 15
- 239000003795 chemical substances by application Substances 0.000 description 12
- 230000000694 effects Effects 0.000 description 11
- 150000002148 esters Chemical class 0.000 description 8
- -1 pyridinyloxy Chemical group 0.000 description 8
- 241000894006 Bacteria Species 0.000 description 7
- 244000060924 Brassica campestris Species 0.000 description 7
- 239000003899 bactericide agent Substances 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
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- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 241000196324 Embryophyta Species 0.000 description 5
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 description 5
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- 150000001875 compounds Chemical class 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 229940051841 polyoxyethylene ether Drugs 0.000 description 5
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- 230000001580 bacterial effect Effects 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 3
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- DMAXMXPDVWTIRV-UHFFFAOYSA-N 2-(2-phenylethyl)phenol Chemical compound OC1=CC=CC=C1CCC1=CC=CC=C1 DMAXMXPDVWTIRV-UHFFFAOYSA-N 0.000 description 2
- AWFYPPSBLUWMFQ-UHFFFAOYSA-N 2-[5-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-1,3,4-oxadiazol-2-yl]-1-(1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C1=NN=C(O1)CC(=O)N1CC2=C(CC1)NN=C2 AWFYPPSBLUWMFQ-UHFFFAOYSA-N 0.000 description 2
- VCUFZILGIRCDQQ-KRWDZBQOSA-N N-[[(5S)-2-oxo-3-(2-oxo-3H-1,3-benzoxazol-6-yl)-1,3-oxazolidin-5-yl]methyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C1O[C@H](CN1C1=CC2=C(NC(O2)=O)C=C1)CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F VCUFZILGIRCDQQ-KRWDZBQOSA-N 0.000 description 2
- 231100000674 Phytotoxicity Toxicity 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000003042 antagnostic effect Effects 0.000 description 2
- 239000012752 auxiliary agent Substances 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- BIKACRYIQSLICJ-UHFFFAOYSA-N cloransulam-methyl Chemical group N=1N2C(OCC)=NC(F)=CC2=NC=1S(=O)(=O)NC1=C(Cl)C=CC=C1C(=O)OC BIKACRYIQSLICJ-UHFFFAOYSA-N 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 229920005552 sodium lignosulfonate Polymers 0.000 description 2
- 238000011179 visual inspection Methods 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- ZFPGARUNNKGOBB-UHFFFAOYSA-N 1-Ethyl-2-pyrrolidinone Chemical compound CCN1CCCC1=O ZFPGARUNNKGOBB-UHFFFAOYSA-N 0.000 description 1
- PYSRRFNXTXNWCD-UHFFFAOYSA-N 3-(2-phenylethenyl)furan-2,5-dione Chemical compound O=C1OC(=O)C(C=CC=2C=CC=CC=2)=C1 PYSRRFNXTXNWCD-UHFFFAOYSA-N 0.000 description 1
- DHTJFQWHCVTNRY-UHFFFAOYSA-N 3-[5-(4-chlorophenyl)-2,3-dimethyl-1,2-oxazolidin-3-yl]pyridine Chemical compound CN1OC(C=2C=CC(Cl)=CC=2)CC1(C)C1=CC=CN=C1 DHTJFQWHCVTNRY-UHFFFAOYSA-N 0.000 description 1
- 241000235349 Ascomycota Species 0.000 description 1
- 241000221198 Basidiomycota Species 0.000 description 1
- 239000005740 Boscalid Substances 0.000 description 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 244000183278 Nephelium litchi Species 0.000 description 1
- WDUHTDGQTRCDHV-UHFFFAOYSA-N O1C=NC=C1.N1=CC=CC=C1.[Cl] Chemical compound O1C=NC=C1.N1=CC=CC=C1.[Cl] WDUHTDGQTRCDHV-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241000233614 Phytophthora Species 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
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- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
- 229920000147 Styrene maleic anhydride Polymers 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 229960000892 attapulgite Drugs 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- WYEMLYFITZORAB-UHFFFAOYSA-N boscalid Chemical compound C1=CC(Cl)=CC=C1C1=CC=CC=C1NC(=O)C1=CC=CN=C1Cl WYEMLYFITZORAB-UHFFFAOYSA-N 0.000 description 1
- 229940118790 boscalid Drugs 0.000 description 1
- OOCMUZJPDXYRFD-UHFFFAOYSA-L calcium;2-dodecylbenzenesulfonate Chemical compound [Ca+2].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O.CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O OOCMUZJPDXYRFD-UHFFFAOYSA-L 0.000 description 1
- 239000006229 carbon black Substances 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- JBDHZKLJNAIJNC-LLVKDONJSA-N clodinafop-propargyl Chemical group C1=CC(O[C@H](C)C(=O)OCC#C)=CC=C1OC1=NC=C(Cl)C=C1F JBDHZKLJNAIJNC-LLVKDONJSA-N 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 235000021186 dishes Nutrition 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000010696 ester oil Substances 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 229910021485 fumed silica Inorganic materials 0.000 description 1
- 244000053095 fungal pathogen Species 0.000 description 1
- 230000009036 growth inhibition Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 230000009916 joint effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- BSDQITJYKQHXQR-UHFFFAOYSA-N methyl prop-2-eneperoxoate Chemical compound COOC(=O)C=C BSDQITJYKQHXQR-UHFFFAOYSA-N 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 229910052625 palygorskite Inorganic materials 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/24—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing the groups, or; Thio analogues thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a bactericidal composition containing pyridinconazole and nitrapyrin methyl, the effective active ingredients of the bactericidal composition contain the pyridinconazole and the nitrapyrin methyl, the weight ratio of the pyridinconazole to the nitrapyrin methyl is 1-50:50-1, the synergistic effect is obvious, and the bactericidal composition can be used for preventing and treating sclerotinia rot of colza, gray mold of crops, rice sheath blight disease, wheat sheath blight disease, cucumber powdery mildew and wheat powdery mildew.
Description
Technical Field
The invention belongs to the field of agricultural bactericides, and particularly relates to a bactericidal composition containing pyridinconazole and nitrapyrin-methyl and application thereof.
Background
Pyrisoxazole, also known as: pyrisoxazole, chemical name: the 5- (4-chlorphenyl) -2, 3-dimethyl-3- (3-pyridyl) isoxazoline is an isoxazole heterocyclic substituted compound with a novel chemical structure, has high bactericidal activity, prevention and treatment effects, good systemic conductivity and good control effect on various plant diseases caused by ascomycetes, basidiomycetes and deuteromycetes. The structure formula of the pyrisoxazole is as follows:
the nitrapyrin-methyl is a novel methoxy acrylate (QoIs) bactericide, has the advantages of wide bactericidal spectrum, long persistent period and high bactericidal activity, is particularly excellent in the aspect of preventing and treating powdery mildew which is the most important crop disease, and is safe to crops and environment. In a bactericidal spectrum screening test, the nitrapyrin strobilus-B has good inhibitory activity on corn small spot disease, rice blast, false smut, rice sheath blight, wheat root rot, tomato gray mold, rape sclerotinia rot, peronophythora litchi and the like, and has good commercial development prospect and competitive advantage. The chemical structural formula is as follows:
practice shows that the long-term use of chemical agents easily causes the generation of drug resistance of pathogenic bacteria, the dosage is continuously increased, the risk is increased, and the sustainable development is not facilitated. Under the condition of lacking of disease-resistant varieties, in order to delay or overcome the formation and development of drug resistance of pathogenic bacteria, a single bactericide is prevented from being continuously used as much as possible, and the bactericide is used alternately or in a mixed manner with other types of bactericides, and pesticide compounding is one of the main ways for solving the occurrence of resistance. The pyridinconazole and the nitrapyrin are bactericides with proprietary intellectual property rights and developed by Shenyang chemical research institute, and the preliminary search of the applicant does not find a report that the pyridinconazole and the nitrapyrin are used in combination to control plant diseases.
The inventor compounds the pyridine bacterium oxazole and the nitrapyrin bacterium ester on the basis of indoor screening and field tests, finds that the pyridine bacterium oxazole and the nitrapyrin bacterium ester have obvious synergistic action on sclerotinia rot of colza, and completes the invention through further research.
Disclosure of Invention
The invention aims to solve the technical problem of providing a composition which has good bactericidal effect, low medication cost, wide bactericidal spectrum and obvious synergistic effect on sclerotinia rot of colza, gray mold of crops, rice sheath blight disease, wheat sharp eyespot, powdery mildew of cucumber and wheat powdery mildew. In order to solve the technical problems, the invention provides the following technical scheme:
the bactericidal composition containing the pyridinyloxy and the boscalid is characterized in that the active ingredients are the pyridinyloxy and the cloransulam-methyl, the weight ratio of the pyridinyloxy to the cloransulam-methyl is 1-50:50-1, the preferable weight ratio is 1-30:30-1, and in some preferable technical schemes: the weight ratio of the pyridinconazole to the nitrapyrin can be 1:50, 1:40, 1:30, 1:20, 1:10, 1:1, 10:1, 20:1, 30:1, 40:1, 50: 1; the content of effective components is 1-90%, preferably 20-75%.
The composition of the invention is mainly used for preventing and treating sclerotinia rot of colza, and if the sclerotinia rot of colza can be used for preventing and treating other plant fungal diseases, such as crop gray mold, rice sheath blight, wheat sharp eyespot, cucumber powdery mildew, wheat powdery mildew and the like.
The composition can be prepared into different preparation formulations according to a method known by a person skilled in the art, wherein the preparation formulations comprise water dispersible granules, wettable powder, suspending agents, aqueous emulsion, microemulsion and the like, and when the preparation formulations are prepared, known auxiliary agents such as emulsifying agents, wetting dispersing agents, suspending agents, disintegrating agents, binding agents, antifreezing agents, thickening agents, stabilizing agents, defoaming agents and other suitable auxiliary agents in pesticides can be added into the preparation formulations according to needs.
The advantages of the invention are obvious and mainly appear as follows:
1. the pyrisoxazole and the clodinafop-propargyl have no antagonistic action, and have obvious synergistic effect on sclerotinia sclerotiorum;
2. the composition of the invention expands the bactericidal spectrum and has better bactericidal effect; meanwhile, the application of the composition can delay or overcome the drug resistance of pathogenic bacteria and prolong the service life of the medicament.
3. The composition disclosed by the invention can reduce the use amount of each single agent by compounding and synergism, is low in cost and is easy to popularize.
Detailed Description
The present invention is further illustrated by the following examples, wherein the percentages are by weight, but the present invention is not limited thereto.
1. Indoor activity determination:
the indoor toxicity determination method comprises the following steps: preparing the pyridinconazole oxazole and the nitrapyrin strobilurin into required liquid medicine according to the set proportioning concentration for later use. The test method refers to part 2 of indoor bioassay test criteria bactericides of NY/T1156.2-2006 pesticide: the plate method of pathogenic fungus hypha growth inhibition test.
Under aseptic condition, quantitatively adding the pre-melted culture medium into an aseptic conical flask, sequentially and quantitatively sucking the liquid medicine from low concentration to high concentration, respectively adding into the above conical flasks, and sufficiently shaking. Then pouring the mixture into more than 3 culture dishes with the diameter of 9cm in equal amount to prepare the drug-containing plates with corresponding concentrations. Treatment without agent served as a blank. Repeat 4 times.
The cultured pathogenic bacteria are cultured at 25 deg.C by punching bacterial plate from the edge of bacterial colony with a punch with diameter of 5mm under aseptic condition, inoculating the bacterial plate to the center of the medicated plate with inoculating needleCulturing for 2 days, measuring colony diameter by cross method, and calculating effective medium dose (EC) for inhibiting growth of bacteria by 50% according to the following formula50Value), and comparing the antibacterial activity, and evaluating the synergistic effect of the bactericidal composition containing the pyrisoxazole and the nitrapyrin-strobin on sclerotinia sclerotiorum by adopting a cotoxicity coefficient method. The joint action of the compound medicament on sclerotinia sclerotiorum is evaluated by the co-toxicity coefficient>120 is expressed as synergistic effect, the co-toxicity coefficient is expressed as additive effect between 80 and 120, and the co-toxicity coefficient<80 is shown as antagonistic.
TABLE 1 results of the combined action of compositions of different ratios on Sclerotinia sclerotiorum
| Medicament | Proportioning | EC50(mg/L) | Co-toxicity coefficient |
| Pyridinioxazole | —— | 0.192 | —— |
| Chloropyricarb ester | —— | 0.028 | —— |
| Pyrisoxazole: chloropyricarb ester | 1:50 | 0.022 | 129.44 |
| Pyrisoxazole: chloropyricarb ester | 10:30 | 0.028 | 127.15 |
| Pyrisoxazole: chloropyricarb ester | 20:20 | 0.036 | 135.76 |
| Pyrisoxazole: chloropyricarb ester | 30:10 | 0.062 | 125.67 |
| Pyrisoxazole: chloropyricarb ester | 50:1 | 0.132 | 130.47 |
The determination results in table 1 show that the composition of the pyrisoxazole and the nitrapyrin strobilurin has obvious synergistic effect on sclerotinia sclerotiorum within the ratio range of 1-50:50-1, and the drug effect is obviously better than the effect of each single-dose single test.
2. Formulation examples
The present invention is further illustrated by the following examples, wherein the percentages are by weight, but the present invention is not limited thereto, and the processing of the various dosage forms of the composition of the present invention is well known in the art and may vary depending on the circumstances.
Example 1: 11% pyridinconazole oxazole-cloxacarb wettable powder
10% of pyridinoxazole, 1% of nitrapyrin, 4% of sodium lignosulfonate, 3% of sodium dodecyl benzene sulfonate, 5% of white carbon black, 1% of xanthan gum and the balance of attapulgite to 100%.
Example 2: 50% pyridinconazole oxazole-cloxacarb missible oil
10% of pyridinconazole oxazole, 40% of nitrapyrin, 7% of calcium dodecyl benzene sulfonate, 13% of sorbitan fatty acid ester, 1% of propylene glycol and 100% of N-ethyl pyrrolidone.
Example 3: water dispersible granule containing 40% pyrisoxazole and clodinstrobin
20% of pyridinconazole, 20% of nitrapyrin, 7% of sodium lignosulfonate, 8% of sodium dodecyl benzene sulfonate, 2% of ethoxylated castor oil, 2% of ammonium sulfate and the balance of diatomite to 100%.
Example 4: 55% pyridinyloxy oxazole-clorstrobin suspending agent
23% of pyridinoxazole, 32% of nitrapyrin, 13% of phenethyl phenol polyoxyethylene ether phosphate, 6% of alkylphenol polyoxyethylene, 2% of xanthan gum and 2% of propylene glycol, and water is added to 100 g.
Example 5: 47% pyridinyloxy oxazole-clorstrobin microemulsion
25% of pyridinoxazole, 22% of nitrapyrin, 7% of sodium dodecyl benzene sulfonate, 4% of 5% phenethyl phenol polyoxyethylene ether, 1% of glycerol and the balance of water to 100%.
Example 6: 60% pyridine bacterium oxazole-chlorine pyridine bacterium ester oil suspending agent
20% of pyridinyloxy, 40% of nitrapyrin, 6% of sorbitan monostearate, 4% of fatty alcohol-polyoxyethylene ether, 2% of castor oil polyoxyethylene ether, 3% of styrylphenol polyoxyethylene ether, 2% of styrene maleic anhydride copolymer ammonium salt, 1% of organic bentonite and 0.5% of fumed silica; 2% of glycerol and 100% of mineral oil.
3. Test of field drug effect
Drug efficacy test example A
Reagent to be tested: examples 1-6 and control.
Control agents:
25% pyrisoxazole emulsifiable concentrate (control 1);
15% clorine-nalidixic-methyl emulsifiable concentrate (control agent 2).
And (3) controlling crops: and (3) rape.
Control target: sclerotinia rot of colza.
The test method comprises the following steps: according to the area of the test cell (about 20 m)2) Accurately weighing each medicament, diluting with water, applying the medicament once by using a knapsack sprayer when about 10 percent of rape main stems bloom, applying the medicament once after 5-7 days, applying the medicament twice in total, investigating disease indexes and calculating prevention effect one week before harvesting. The results are shown in Table 2.
TABLE 2 field test results of the efficacy of the compositions of the present invention against sclerotinia rot of colza
| Treatment agent | Dosage (g a.i/mu) | Sclerotinia rot control of colza (%) |
| Example 1 | 10 | 87.41 |
| Example 2 | 10 | 87.94 |
| Example 3 | 10 | 87.21 |
| Example 4 | 10 | 88.01 |
| Example 5 | 10 | 85.30 |
| Example 6 | 10 | 85.37 |
| Control drug 1 | 20 | 80.17 |
| Control agent 2 | 15 | 83.96 |
The field test result shows that the compound of the pyrisoxazole and the nitrapyrin-strobin has better control effect on the sclerotinia rot of the rape, compared with a control example, the activity is greatly improved, the synergistic effect is obvious, and meanwhile, the using dose of the chemical pesticide in the field is obviously reduced. According to field visual inspection, in the test dosage range, crops grow normally, and no phytotoxicity and abnormal phenomena of plants are generated, so that the rape production is safe.
Drug efficacy test example B
Reagent to be tested: examples 1-6 and control.
Control agents:
25% pyrisoxazole emulsifiable concentrate (control 1);
15% clorine-nalidixic-methyl emulsifiable concentrate (control agent 2).
And (3) controlling crops: cucumber.
Control target: powdery mildew of cucumber.
The test method comprises the following steps: by adopting greenhouse test, each cell is 8m2After different medicaments are diluted, a knapsack sprayer is adopted to apply the medicaments once at the early stage of disease attack,the medicine is applied once after 5 to 7 days, the medicine is applied twice in total, and the disease index is respectively investigated and the prevention effect is calculated 14 days after the last medicine application. The results are shown in Table 3.
TABLE 3 field efficacy test results of the compositions of the present invention against cucumber powdery mildew
| Treatment agent | Dosage (g a.i/mu) | Control effect of cucumber powdery mildew (%) |
| Example 1 | 10 | 91.23 |
| Example 2 | 10 | 90.89 |
| Example 3 | 10 | 93.81 |
| Example 4 | 10 | 92.12 |
| Example 5 | 10 | 89.26 |
| Example 6 | 10 | 90.33 |
| Control drug 1 | 20 | 85.61 |
| Control agent 2 | 15 | 86.2 |
The field test result shows that the compound of the pyrisoxazole and the nitrapyrin-strobin has good control effect on cucumber powdery mildew, compared with a control example, the control effect is obviously improved, the synergistic effect is obvious, and meanwhile, the use dosage of chemical pesticide in the field is obviously reduced. According to field visual inspection, in the test dosage range, the crops grow normally, and no phytotoxicity and abnormal phenomena are generated in plants, so that the cucumber production is safe.
While the foregoing is directed to the preferred embodiment of the present invention, it will be understood by those skilled in the art that various changes and modifications may be made without departing from the spirit and scope of the invention as defined in the appended claims.
Claims (7)
1. The bactericidal composition containing the pyridinconazole and the nitrapyrin strobilurin is characterized in that the active ingredients are the pyridinconazole and the nitrapyrin strobilurin, and the weight ratio of the pyridinconazole to the nitrapyrin strobilurin is 1-50: 50-1.
2. The bactericidal composition of claim 1, wherein the weight ratio of pyrisoxazole to nitrapyrin-strobin is 1-30: 30-1.
3. The bactericidal composition of claim 1, wherein the active ingredient is present in the composition in an amount of 1 to 90%.
4. The bactericidal composition of claim 3, wherein the active ingredient is present in the composition in an amount of 20% to 75%.
5. The bactericidal composition according to any one of claims 1 to 4, wherein the active ingredient is formulated into any formulation that is agriculturally acceptable with conventional adjuvants that are agriculturally acceptable in the formulation of the pesticide.
6. The bactericidal composition of claim 5, wherein the formulation is water dispersible granules, wettable powder, suspoemulsion, aqueous emulsion, or microemulsion.
7. The use of the fungicidal composition of any of claims 1 to 6 for the control of sclerotinia rot of colza, gray mold of crops, sheath blight of rice, sheath blight of wheat, powdery mildew of cucumber, powdery mildew of wheat.
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| CN1814590A (en) * | 2005-02-06 | 2006-08-09 | 沈阳化工研究院 | N-(2-substituted phenyl)-N-methoxy carbamate compounds and their preparation and use |
| CN101087529A (en) * | 2004-12-23 | 2007-12-12 | 巴斯福股份公司 | Fungicidal mixtures |
| CN101087523A (en) * | 2004-12-23 | 2007-12-12 | 巴斯福股份公司 | Fungicidal mixtures |
| WO2016175200A1 (en) * | 2015-04-27 | 2016-11-03 | 日本農薬株式会社 | Plant disease control agent and utilization thereof |
| CN106852332A (en) * | 2015-12-08 | 2017-06-16 | 中化农化有限公司 | Bactericidal composition containing SYP-Z048 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101087529A (en) * | 2004-12-23 | 2007-12-12 | 巴斯福股份公司 | Fungicidal mixtures |
| CN101087523A (en) * | 2004-12-23 | 2007-12-12 | 巴斯福股份公司 | Fungicidal mixtures |
| CN1814590A (en) * | 2005-02-06 | 2006-08-09 | 沈阳化工研究院 | N-(2-substituted phenyl)-N-methoxy carbamate compounds and their preparation and use |
| WO2016175200A1 (en) * | 2015-04-27 | 2016-11-03 | 日本農薬株式会社 | Plant disease control agent and utilization thereof |
| CN106852332A (en) * | 2015-12-08 | 2017-06-16 | 中化农化有限公司 | Bactericidal composition containing SYP-Z048 |
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