CN110787362B - Atmospheric-pressure aloe discharge plasma acne removal device and using method thereof - Google Patents
Atmospheric-pressure aloe discharge plasma acne removal device and using method thereof Download PDFInfo
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- 206010000496 acne Diseases 0.000 abstract description 19
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- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
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Abstract
Description
技术领域technical field
本发明涉及医疗设备领域,具体的,涉及一种大气压芦荟放电等离子体祛痘装置及其使用方法。The invention relates to the field of medical equipment, in particular to an atmospheric pressure aloe discharge plasma acne removing device and a method for using the same.
背景技术Background technique
芦荟含有丰富的营养物质,其制品常用于食品、美容、保健、医药等领域,在医学上的应用也比较广泛。在芦荟中物质主要分为两类:蒽醌类化合物C14H8O2和多糖(C6H10O5)n,蒽醌类化合物可以抑制菌体糖及代谢中间产物的氧化和脱氢,并能抑制蛋白和核酸的合成,因此可避免临床上某些抗菌素的毒副反应及耐药性。此外,芦荟富含大量的-COOH羧基化学键分子,呈现弱酸性,能够消毒杀菌和祛痘养颜,大多数芦荟都以固态或液态直接使用。Aloe vera is rich in nutrients, and its products are often used in food, beauty, health care, medicine and other fields, and are also widely used in medicine. Substances in aloe vera are mainly divided into two categories: anthraquinone compounds C 14 H 8 O 2 and polysaccharides (C 6 H 10 O 5 ) n . Anthraquinone compounds can inhibit the oxidation and dehydrogenation of bacterial sugars and metabolic intermediates , and can inhibit the synthesis of protein and nucleic acid, so it can avoid the side effects and drug resistance of some clinical antibiotics. In addition, aloe vera is rich in a large number of -COOH carboxyl chemical bond molecules, showing weak acidity, which can disinfect and sterilize, remove acne, and beautify the face. Most aloe vera is used directly in solid or liquid form.
等离子体包含电子、离子、自由基、激发态原子与分子等活性组分。大气压非平衡等离子体射流装置产生的等离子体温度基本保持在常温,对人体不会产生电伤害。由于大气压非平衡等离子体射流温度低、可控性好、能耗小,可在开放空间产生等离子体,在生物医学等方面有广阔的应用前景和重要的研究意义。Plasma contains active components such as electrons, ions, free radicals, excited atoms and molecules. The temperature of the plasma generated by the atmospheric pressure non-equilibrium plasma jet device is basically maintained at room temperature, and will not cause electrical damage to the human body. Due to the low temperature, good controllability and low energy consumption of atmospheric pressure non-equilibrium plasma jet, plasma can be generated in open space, which has broad application prospects and important research significance in biomedicine and other fields.
汽化是指物质从液态变为气态的相变过程,液体的分子间距小,而气体的分子间距大,可通过降压升温的方法使液态为气态。Vaporization refers to the phase transition process of a substance from a liquid state to a gas state. The molecular spacing of liquid is small, while the molecular spacing of gas is large.
发明人认为,由于人体皮肤的角质层一般是15μm左右的厚度,而药物涂抹于皮肤表面时,起功效作用的活性因子并不能渗透到皮肤角质层下,只能在皮肤表面,暂时消灭表面细菌、假性祛痘,并不能起到从根部祛痘的功效。The inventor believes that since the stratum corneum of human skin is generally about 15 μm thick, when the drug is applied to the surface of the skin, the active factors that play a role cannot penetrate into the stratum corneum of the skin, and can only temporarily eliminate surface bacteria on the surface of the skin. , fake acne, and can not play the effect of acne from the root.
发明内容SUMMARY OF THE INVENTION
针对现有涂抹药物祛痘的方法和疗效的不足,本发明旨在提供一种大气压芦荟放电等离子体祛痘装置及其使用方法,其使用大气压非平衡等离子体射流机构将含有芦荟活性成分的溶剂以等离子体的形式射出,能够渗透到皮肤表层以下,从而解决涂抹药物所达不到的效果。Aiming at the deficiencies of the existing methods and curative effects of applying medicine for acne treatment, the present invention aims to provide an atmospheric pressure aloe vera discharge plasma acne treatment device and a method for using the same. It is ejected in the form of plasma and can penetrate below the surface of the skin, thereby solving the effects that cannot be achieved by applying medicines.
本发明的第一目的,是提供一种大气压芦荟放电等离子体祛痘装置。The first object of the present invention is to provide an atmospheric pressure aloe discharge plasma acne treatment device.
本发明的第二目的,是提供一种大气压芦荟放电等离子体祛痘装置的使用方法。The second object of the present invention is to provide a method for using an atmospheric pressure aloe discharge plasma acne treatment device.
为实现上述发明目的,本发明公开了下述技术方案:In order to realize the above-mentioned purpose of the invention, the present invention discloses the following technical solutions:
第一方面,本发明公开了一种大气压芦荟放电等离子体祛痘装置,包括第一瓶体、第二瓶体、汽化机构、预混机构和大气压非平衡等离子体射流机构,第一瓶体用于盛装惰性气体,第二瓶体用于盛装含有芦荟成分的溶剂,第二瓶体连通于汽化机构;第一瓶体和汽化机构连通预混机构,预混机构连通大气压非平衡等离子体射流机构。In the first aspect, the present invention discloses an atmospheric pressure aloe discharge plasma acne treatment device, including a first bottle body, a second bottle body, a vaporization mechanism, a premixing mechanism and an atmospheric pressure non-equilibrium plasma jet mechanism. For containing inert gas, the second bottle body is used to contain the solvent containing aloe vera components, and the second bottle body is connected to the vaporization mechanism; the first bottle body and the vaporization mechanism are connected to the premixing mechanism, and the premixing mechanism is connected to the atmospheric pressure non-equilibrium plasma jet mechanism. .
进一步,所述汽化机构包括减压阀和安全阀,所述第一瓶体的开口和所述第二瓶体的开口均连接减压阀的高压腔接瓶口,减压阀的低压腔接出气口,减压阀还连接安全阀。Further, the vaporization mechanism includes a pressure reducing valve and a safety valve, the opening of the first bottle body and the opening of the second bottle body are both connected to the high pressure chamber of the pressure reducing valve and the bottle mouth, and the low pressure chamber of the pressure reducing valve is connected to the bottle mouth. The air outlet, the pressure reducing valve is also connected to the safety valve.
进一步,所述预混机构为螺旋式管道混合器。Further, the premixing mechanism is a helical pipeline mixer.
进一步,所述螺旋式管道混合器的管内具有多个螺旋式混合单元,螺旋式管道混合器竖直放置。Further, a plurality of helical mixing units are arranged in the pipe of the helical pipe mixer, and the helical pipe mixer is placed vertically.
进一步,所述大气压非平衡等离子体射流机构采用射频电源驱动,射频能量通过脉冲调制、射频匹配器,在石英管内形成等离子体。Further, the atmospheric pressure unbalanced plasma jet mechanism is driven by a radio frequency power supply, and the radio frequency energy forms plasma in the quartz tube through pulse modulation and a radio frequency matching device.
进一步,所述大气压非平衡等离子体射流装置的射频电源频率为13.56MHz。Further, the frequency of the radio frequency power supply of the atmospheric pressure non-equilibrium plasma jet device is 13.56MHz.
进一步,所述大气压非平衡等离子体射流装置包括石英管、高压电极和环形接地电极,高压电机位于石英管中,环形接地电极位于石英管的端部,石英管的管壁连通预混机构,环形接地电极和高压电极均连接射频电源。Further, the atmospheric pressure unbalanced plasma jet device includes a quartz tube, a high-voltage electrode and a ring-shaped ground electrode, the high-voltage motor is located in the quartz tube, the ring-shaped ground electrode is located at the end of the quartz tube, and the wall of the quartz tube is connected to the premixing mechanism, and the ring-shaped ground electrode is located in the quartz tube. Both the ground electrode and the high voltage electrode are connected to the radio frequency power supply.
进一步,所述石英管壁具有圆柱形进气口,圆柱形进气口连通预混机构;Further, the quartz tube wall has a cylindrical air inlet, and the cylindrical air inlet communicates with the premixing mechanism;
所述高压电极为针电极,所述高压电极的长度大于所述石英管的长度,所述高压电极在轴向方向穿过所述石英管;The high-voltage electrode is a needle electrode, the length of the high-voltage electrode is greater than the length of the quartz tube, and the high-voltage electrode passes through the quartz tube in the axial direction;
所述环形接地电极位于接近圆柱石英管上管口处。The annular ground electrode is located near the upper orifice of the cylindrical quartz tube.
进一步,所述石英管外径为1.8mm,内径为1.6mm,长为60mm;Further, the outer diameter of the quartz tube is 1.8mm, the inner diameter is 1.6mm, and the length is 60mm;
所述高压电极为直径为1mm、长为75mm的针电极;The high-voltage electrode is a needle electrode with a diameter of 1 mm and a length of 75 mm;
所述环形接地电极内径为1.8mm、外径为1.9mm、宽为5mm。The annular ground electrode has an inner diameter of 1.8 mm, an outer diameter of 1.9 mm, and a width of 5 mm.
进一步,所述惰性气体为氩气。Further, the inert gas is argon.
第二方面,本发明公开了一种大气压芦荟放电等离子体祛痘装置的使用方法,包括以下步骤:In a second aspect, the present invention discloses a method for using an atmospheric pressure aloe discharge plasma acne treatment device, comprising the following steps:
在第一瓶体中灌入惰性气体,在第二瓶体中灌入含有芦荟成分的溶剂;Inert gas is poured into the first bottle body, and a solvent containing aloe vera is poured into the second bottle body;
加热第二瓶体,并使用汽化装置汽化第二瓶体中的含有芦荟成分的溶剂;heating the second bottle body, and vaporizing the solvent containing the aloe vera component in the second bottle body by using a vaporizing device;
使用预混机构混合汽化的含有芦荟成分的溶剂以及惰性气体得到混合溶剂;Use a premixing mechanism to mix the vaporized aloe vera-containing solvent and an inert gas to obtain a mixed solvent;
通电的大气压非平衡等离子体射流装置将混合溶剂以等离子体发射。An energized atmospheric pressure non-equilibrium plasma jet device emits the mixed solvent as a plasma.
与现有技术相比,本发明取得了以下有益效果:Compared with the prior art, the present invention has achieved the following beneficial effects:
1)本发明中,使用大气压非平衡等离子体射流机构将含有芦荟活性成分的溶剂以等离子体的形式射出,能够渗透到皮肤表层以下,从而解决涂抹药物所达不到的效果,将芦荟的活性成分送入皮下组织,充分祛痘。1) In the present invention, the non-equilibrium plasma jet mechanism of atmospheric pressure is used to eject the solvent containing the active ingredient of aloe vera in the form of plasma, which can penetrate below the skin surface layer, thereby solving the effect that cannot be achieved by applying medicine, and reducing the activity of aloe vera. The ingredients are sent into the subcutaneous tissue to fully remove acne.
2)本发明中,使用低温汽化装置,充分利用了压强的变化对含有芦荟活性成分的溶剂进行汽化,保证了芦荟在汽化的过程中的活性;并且,汽化后的芦荟在大气压非平衡等离子体射流装置的处理过程中,由于其处理温度低,也不会丧失过多的活性物质,可以保证其作用于祛痘的功效。2) In the present invention, using a low-temperature vaporization device, the change in pressure is fully utilized to vaporize the solvent containing the active ingredient of aloe, to ensure the activity of the aloe in the vaporized process; and, the vaporized aloe is in the atmospheric pressure non-equilibrium plasma During the treatment process of the jet device, due to its low treatment temperature, too much active substances will not be lost, which can ensure its effect on acne removal.
3)本发明中,使用螺旋式管道混合器混合惰性气体和汽化后的含有芦荟活性物质的溶剂,能够保证两者的充分混合,以利于大气压非平衡等离子体射流装置对混合气体的处理,使得混合气体中的多种气体成分能够被激发为等离子体,并携带汽化后的含有芦荟活性物质的溶剂进入皮下组织。3) In the present invention, the use of the spiral pipeline mixer to mix the inert gas and the vaporized solvent containing the aloe active substance can ensure that the two are fully mixed, so as to facilitate the treatment of the mixed gas by the atmospheric pressure non-equilibrium plasma jet device, so that Various gas components in the mixed gas can be excited into plasma, and carry the vaporized solvent containing aloe vera active substances into the subcutaneous tissue.
附图说明Description of drawings
构成本发明的一部分的说明书附图用来提供对本发明的进一步理解,本发明的示意性实施例及其说明用于解释本发明,并不构成对本发明的不当限定。The accompanying drawings forming a part of the present invention are used to provide further understanding of the present invention, and the exemplary embodiments of the present invention and their descriptions are used to explain the present invention, and do not constitute an improper limitation of the present invention.
图1为实施例1结构示意图。FIG. 1 is a schematic structural diagram of Embodiment 1. FIG.
图中,1、第一瓶体,2、第二瓶体,3、减压阀,4、进气口,5、螺旋式管道混合器,6、螺旋式管道混合器的出气口,7、石英管的进气口,8、高压电极,9、环形接地电极,10、石英管,11、射频电源,12、脉冲调制器,13、射频匹配器,14、气体流量计。In the figure, 1, the first bottle body, 2, the second bottle body, 3, the pressure reducing valve, 4, the air inlet, 5, the spiral pipeline mixer, 6, the air outlet of the spiral pipeline mixer, 7, Inlet of quartz tube, 8. High voltage electrode, 9. Ring ground electrode, 10. Quartz tube, 11. RF power supply, 12. Pulse modulator, 13. RF matching device, 14. Gas flow meter.
具体实施方式Detailed ways
应该指出,以下详细说明都是例示性的,旨在对本发明提供进一步的说明。除非另有指明,本文使用的所有技术和科学术语具有与本发明所属技术领域的普通技术人员通常理解的相同含义。It should be noted that the following detailed description is exemplary and intended to provide further explanation of the invention. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
在本发明的描述中,需要说明的是,术语“上”、“下”、“左”、“右”、“竖直”、“水平”、“内”、“外”等指示的方位或位置关系为基于附图所示的方位或位置关系,仅是为了便于描述本发明和简化描述,而不是指示或暗示所指的装置或元件必须具有特定的方位、以特定的方位构造和操作,因此不能理解为对本发明的限制,此外,术语“第一”、“第二”、等仅用于描述目的,而不能理解为指示或暗示相对重要性。In the description of the present invention, it should be noted that the terms "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. indicate the orientation or The positional relationship is based on the orientation or positional relationship shown in the accompanying drawings, which is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, Therefore, it should not be construed as a limitation of the present invention, and further, the terms "first", "second", etc. are used for descriptive purposes only and should not be construed as indicating or implying relative importance.
需要注意的是,这里所使用的术语仅是为了描述具体实施方式,而非意图限制根据本发明的示例性实施方式。如在这里所使用的,除非上下文另外明确指出,否则单数形式也意图包括复数形式,此外,还应当理解的是,当在本说明书中使用术语“包含”和/或“包括”时,其指明存在特征、步骤、操作、器件、组件和/或它们的组合。It should be noted that the terminology used herein is for the purpose of describing specific embodiments only, and is not intended to limit the exemplary embodiments according to the present invention. As used herein, unless the context clearly dictates otherwise, the singular is intended to include the plural as well, furthermore, it is to be understood that when the terms "comprising" and/or "including" are used in this specification, it indicates that There are features, steps, operations, devices, components and/or combinations thereof.
正如背景技术所述,针对现有涂抹药物祛痘的方法和疗效的不足,本发明旨在提供一种大气压芦荟放电等离子体祛痘装置及其使用方法,其使用大气压非平衡等离子体射流机构将含有芦荟活性成分的溶剂以等离子体的形式射出,能够渗透到皮肤表层以下,从而解决涂抹药物所达不到的效果,现结合附图和具体实施方式对本发明进一步进行说明。As described in the background art, in view of the deficiencies of the existing methods and curative effects of applying medicine for acne treatment, the present invention aims to provide an atmospheric pressure aloe vera discharge plasma acne treatment device and a method for using the same, which use an atmospheric pressure non-equilibrium plasma jet mechanism to The solvent containing the active ingredient of aloe vera is ejected in the form of plasma, which can penetrate below the skin surface layer, so as to solve the effect that cannot be achieved by applying medicine.
实施例1Example 1
本实施例公开了一种大气压芦荟放电等离子体祛痘装置,包括第一瓶体1、第二瓶体2、汽化机构、预混机构和大气压非平衡等离子体射流机构,第一瓶体1用于盛装惰性气体,第二瓶体2用于盛装含有芦荟成分的溶剂,第二瓶体2连通于汽化机构;第一瓶体和汽化机构连通预混机构,预混机构连通大气压非平衡等离子体射流机构。This embodiment discloses an atmospheric pressure aloe discharge plasma acne treatment device, including a first bottle body 1, a
本实施例中的第一瓶体1中盛装的气体为氩气,也可以使用氦气或其他惰性气体,惰性气体在经过激发后能够形成等离子体射流。本实施例中第二瓶体2中盛装的是纯净无氧化的芦荟汁。In this embodiment, the gas contained in the first bottle body 1 is argon gas, and helium gas or other inert gas can also be used, and the inert gas can form a plasma jet after being excited. In this embodiment, the
可以理解的是,本实施例中的装置还包括气体流量计14,气体流量计14安装于第一瓶体1至汽化机构、第二瓶体2至预混机构的通路,气体流量计14用于控制氩气和芦荟气体的流量,两种气体流量均为2.5L/min。It can be understood that the device in this embodiment also includes a
所述汽化机构包括减压阀3和安全阀,所述第一瓶体1的开口和所述第二瓶体2的开口均连接减压阀3的高压腔接瓶口,减压阀3的低压腔接出气口,减压阀3还连接安全阀。The vaporization mechanism includes a pressure reducing valve 3 and a safety valve. The opening of the first bottle body 1 and the opening of the
所述预混机构为螺旋式管道混合器5。The premixing mechanism is a
所述螺旋式管道混合器5的管内具有多个螺旋式混合单元,螺旋式管道混合器5竖直放置。The
可以理解的是,螺旋式管道混合器5的管内直径为25mm,长度为330mm,管内包含6-8个螺旋式混合单元不断地交叉流动,使两种气体能均匀混合。管道混合器垂直放置,氩气入口为下左端口,芦荟汽化气体入口为下右端口。It can be understood that the inner diameter of the
所述大气压非平衡等离子体射流机构采用射频电源11驱动,射频能量通过脉冲调制、射频匹配器13,在石英管10内形成等离子体。The atmospheric pressure unbalanced plasma jet mechanism is driven by a radio
所述大气压非平衡等离子体射流装置的射频电源11频率为13.56MHz,功率10~500W间可调,射频电源11电连接脉冲调制器12和射频匹配器13,采用脉冲调制器12调制射频、经过射频匹配器13,在大气压非平衡等离子体射流装置形成放电等离子体。The frequency of the radio
所述大气压非平衡等离子体射流装置包括石英管10、高压电极8和环形接地电极9,高压电机位于石英管10中,环形接地电极9位于石英管10的端部,石英管10的管壁连通预混机构,环形接地电极9和高压电极8均连接射频电源11。The atmospheric pressure unbalanced plasma jet device includes a
进一步,所述石英管10壁具有圆柱形进气口,圆柱形进气口连通预混机构;Further, the wall of the
所述高压电极8为针电极,所述高压电极8的长度大于所述石英管10的长度,所述高压电极8在轴向方向穿过所述石英管10;The high-
所述环形接地电极9位于接近圆柱石英管10上管口处。The annular ground electrode 9 is located near the upper orifice of the
所述石英管10外径为1.8mm,内径为1.6mm,长为60mm;The outer diameter of the
所述高压电极8为直径为1mm、长为75mm的针电极;The high-
所述环形接地电极9内径为1.8mm、外径为1.9mm、宽为5mm。The annular ground electrode 9 has an inner diameter of 1.8 mm, an outer diameter of 1.9 mm, and a width of 5 mm.
管道混合器将两种气体按照一定的比例进行混合,一般为活性气体和惰性气体的混合,在不破坏活性分子的情况下,在等离子体发生装置放电产生带电粒子、激发态粒子、紫外光子、自由基以及其它一些基态粒子。为了防止芦荟汽化后分子之间不稳定易发生碰撞的问题发生,使用管道混合器添加惰性气体使其均匀流动。管内的螺旋式结构可以使氩气和芦荟气体(芦荟汽化后的气体)按照1:1比例混合成工作气体,等离子体射流中的活性粒子具有较高的寿命和渗透深度,能够穿透皮肤角质层,实现根部祛痘,将芦荟与等离子体结合能实现较好的祛痘效果。The pipeline mixer mixes the two gases according to a certain proportion, generally a mixture of active gas and inert gas, without destroying the active molecules, the discharge of the plasma generator generates charged particles, excited particles, ultraviolet photons, Free radicals and some other ground-state particles. In order to prevent the problem that the molecules of aloe vera are unstable and prone to collision after vaporization, use a pipeline mixer to add inert gas to make it flow uniformly. The spiral structure in the tube can mix argon gas and aloe vera gas (the gas after aloe vera vaporization) into a working gas in a ratio of 1:1. The active particles in the plasma jet have a high life span and penetration depth, and can penetrate the skin keratin. Layer, to achieve root acne, the combination of aloe vera and plasma can achieve better acne effect.
可以是理解的是,本实施例所使用的大气压非平衡等离子体射流机构属于类介质阻挡放电射流,其特点是,当等离子体射流不接触任何物体时,放电就像电介质阻挡放电,然而,一旦等离子体射流接触到被处理物,特别是接地导体时,放电就在高压电极8和处理物之间产生。当此类射流用于等离子体医学时,被处理物实际上是人体,由于存在出现电弧的危险,此类射流装置的使用需要十分慎重,目前,已经有大量的临床使用案例,其安全性可以得到保障。It can be understood that the atmospheric pressure non-equilibrium plasma jet mechanism used in this embodiment belongs to the dielectric barrier discharge jet, which is characterized in that when the plasma jet does not touch any object, the discharge is like a dielectric barrier discharge. When the plasma jet comes into contact with the object to be processed, especially the ground conductor, a discharge is generated between the high-
实施例2Example 2
实施例2公开了一种大气压芦荟放电等离子体祛痘装置的使用方法,使用如实施例1所述的大气压芦荟放电等离子体祛痘装置,包括以下步骤:
在第一瓶体中灌入惰性气体,在第二瓶体中灌入含有芦荟成分的溶剂;Inert gas is poured into the first bottle body, and a solvent containing aloe vera is poured into the second bottle body;
加热第二瓶体,并使用汽化装置汽化第二瓶体中的含有芦荟成分的溶剂;heating the second bottle body, and vaporizing the solvent containing the aloe vera component in the second bottle body by using a vaporizing device;
使用预混机构混合汽化的含有芦荟成分的溶剂以及惰性气体得到混合溶剂;Use a premixing mechanism to mix the vaporized aloe vera-containing solvent and an inert gas to obtain a mixed solvent;
通电的大气压非平衡等离子体射流装置将混合溶剂以等离子体发射。An energized atmospheric pressure non-equilibrium plasma jet device emits the mixed solvent as a plasma.
以上所述仅为本发明的优选实施例而已,并不用于限制本发明,对于本领域的技术人员来说,本发明可以有各种更改和变化。凡在本发明的精神和原则之内,所作的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。The above descriptions are only preferred embodiments of the present invention, and are not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and changes. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.
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