CN110755673A - 一种羧甲基纤维素钠液体敷料及其制作方法 - Google Patents
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- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 title claims abstract description 27
- 239000001768 carboxy methyl cellulose Substances 0.000 title claims abstract description 27
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 title claims abstract description 27
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 title claims abstract description 27
- 239000007788 liquid Substances 0.000 title claims abstract description 12
- 238000002360 preparation method Methods 0.000 title abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000008213 purified water Substances 0.000 claims abstract description 15
- 239000002994 raw material Substances 0.000 claims abstract description 14
- 239000003755 preservative agent Substances 0.000 claims abstract description 13
- 230000002335 preservative effect Effects 0.000 claims abstract description 13
- 238000003756 stirring Methods 0.000 claims abstract description 4
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims abstract description 3
- 241000191967 Staphylococcus aureus Species 0.000 claims abstract description 3
- 241001148470 aerobic bacillus Species 0.000 claims abstract description 3
- 230000000813 microbial effect Effects 0.000 claims abstract description 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract 2
- 230000002421 anti-septic effect Effects 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000012856 packing Methods 0.000 claims 1
- 206010052428 Wound Diseases 0.000 abstract description 57
- 208000027418 Wounds and injury Diseases 0.000 abstract description 56
- 238000000034 method Methods 0.000 abstract description 8
- 230000004888 barrier function Effects 0.000 abstract description 5
- 239000011241 protective layer Substances 0.000 abstract description 5
- 208000034656 Contusions Diseases 0.000 abstract description 4
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- 230000000474 nursing effect Effects 0.000 abstract description 3
- 230000002093 peripheral effect Effects 0.000 abstract description 3
- 230000035876 healing Effects 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- ZOMNIUBKTOKEHS-UHFFFAOYSA-L dimercury dichloride Chemical compound Cl[Hg][Hg]Cl ZOMNIUBKTOKEHS-UHFFFAOYSA-L 0.000 description 3
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
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- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
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- 230000029663 wound healing Effects 0.000 description 1
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Abstract
一种羧甲基纤维素钠液体敷料及其制作方法，属于医疗用品的技术领域。羧甲基纤维素钠液体敷料由羧甲基纤维素钠（CMC‑Na）、纯化水、防腐剂组成。微生物限度要求：需氧菌总数每1mL不得超过100个；霉菌和酵母菌总数每1mL不得超过10个；金黄色葡萄球菌、铜绿假单胞菌不得检出。成分配比（重量比）：羧甲基纤维素钠（CMC‑Na）为0.5～50.00%，纯化水、防腐剂适量。工艺方法：按照配方比例称量原料（重量比），将原料羧甲基纤维素钠（CMC‑Na），防腐剂置入加有纯化水的容器内，使之充分溶解制成溶液，搅拌均匀，分装而成。通过在伤口创面表面形成保护层，起物理屏障作用。用于小创口、擦伤、切割伤等浅表性创面及周围皮肤的护理。
Description
技术领域
本发明属于一种利用高分子材料羧甲基纤维素钠（CMC-Na）、纯化水、防腐剂为主要原料制作医疗用品的技术领域。
背景技术
皮肤伤口创伤等皮肤浅表面受损问题是人们正常生活中常见的现象，一旦皮肤造成创伤出现伤口的情况下，就必须采取措施防止伤口创面感染，伤口本身污染的程度与以后是否发生感染有很大的关系，一般伤口分类如下：1.清洁伤口(Clean-Wounds) ---无发炎现象。2.清洁污染伤口(Clean-Contaminated Wounds) ---没有明显污染。3.污染伤口(Contaminated Wounds) ---有急性发炎，但未化脓。有坏死组织的外伤伤口。4.感染伤口(Dirty or Infected Wounds) ---己有感染的伤口。
目前创口处理的方法一般有：
(1)用碘酒或用酒精或用紫水消毒，沿着伤口的边缘由里向外擦，不要把碘酒、酒精涂入伤口内。伤口内如有异物，需要慎重处理取出。
(2)小伤口可以在其浅表涂一点红汞(红药水)(特别注意，红药水与碘酒和碘伏以及任何含碘消毒液不能同时使用，也不可以过于使用红药水)或紫药水。
以上伤口处理方法存在一些不足，伤口容易处于干燥状况，开放的伤口不应使其完全干燥，脱水损伤了伤口底部的组织。上皮细胞在干痂下移行比湿润的伤面困难。这对伤口愈合不利。
发明内容
本发明的目的是提供一种羧甲基纤维素钠液体敷料及其制作方法，通过在创面表面形成保护层，起物理屏障作用。用于小创口、擦伤、切割伤等浅表性创面及周围皮肤的护理。
本发明的技术方案为：
本发明的结构组成是：由羧甲基纤维素钠（CMC-Na）、纯化水、防腐剂组成。非无菌提供。有微生物限度要求（需氧菌总数每1mL不得超过100个；霉菌和酵母菌总数每1mL不得超过10个；金黄色葡萄球菌、铜绿假单胞菌不得检出）。
羧甲基纤维素钠液体敷料的成分配比（重量比）：羧甲基纤维素钠（CMC-Na）为0.1～50.00%，纯化水适量、防腐剂适量。
工艺方法：按照配方比例称量原料，将原料羧甲基纤维素钠（CMC-Na）、防腐剂置入加有纯化水的容器内，使之充分溶解制成溶液，搅拌均匀，分装而成。
本发明主要原料为羧甲基纤维素钠（CMC-Na）是高分子水溶性化合物，是医疗耗材常用的成膜材料。
本发明所要解决的技术问题：采用羧甲基纤维素钠（CMC-Na）、纯化水、防腐剂为主要原料，制成液体敷料，使具在创面形成凝胶保护层的特性，起到物理屏障作用，隔离细菌，具有的吸湿性能，保证了创面适宜的温湿度愈合条件，对创面愈合起到促进的作用。这些特性使敷料覆盖于创面后，在阻隔了大分子物质和细菌入侵的同时，还保证了创面与外界的气体交换，为保证创面处在封闭、温暖、湿润的环境中创造了条件。进而促进小创口、擦伤、切割伤等浅表性创面的愈合。弥补了目前伤口处理方面出现干燥问题的不足之处。
本发明的适用范围是：通过在创面表面形成保护层，起物理屏障作用。用于小创口、擦
伤、切割伤等浅表性创面及周围皮肤的护理。
本发明是由羧甲基纤维素钠（CMC-Na）、纯化水、防腐剂组成的湿性封闭敷料，具有在创面形成凝胶保护层的特性，起到物理屏障作用，隔离细菌，具有的吸湿性能，保证了创面适宜的温湿度愈合条件，对创面愈合起到促进的作用。这些特性使敷料覆盖于创面后，在阻隔了大分子物质和细菌入侵的同时，还保证了创面与外界的气体交换，为保证创面处在封闭、温暖、湿润的环境中创造了条件。进而促进小创口、擦伤、切割伤等浅表性创面的愈合。弥补了目前伤口处理方面出现干燥问题的不足之处。
具体实施方式
1、按照配方比例称量原料（重量比）：羧甲基纤维素钠（CMC-Na）为0.5～20.00%，、纯化水、防腐剂适量。
2、按工艺方法，按照配方比例称量原料，将原料羧甲基纤维素钠（CMC-Na）、防腐剂置入加有纯化水的容器内，使之充分溶解制成溶液，搅拌均匀，分装而成。
Claims (5)
1.一种羧甲基纤维素钠液体敷料，其特征是由羧甲基纤维素钠（CMC-Na）、纯化水、防腐剂组成。
2.根据权利要求1所述的羧甲基纤维素钠液体敷料，其特征是微生物限度要求：需氧菌总数每1mL不得超过100个；霉菌和酵母菌总数每1mL不得超过10个；金黄色葡萄球菌、铜绿假单胞菌不得检出。
3.根据权利要求1所述的羧甲基纤维素钠液体敷料，其特征是羧甲基纤维素钠液体敷料的成分配比（重量比）：羧甲基纤维素钠（CMC-Na）为0.1～50.00%，纯化水适量、防腐剂适量。
4.一种羧甲基纤维素钠液体敷料制作方法，其特征是按照配方比例称量原料（重量比），将原料羧甲基纤维素钠（CMC-Na）、防腐剂置入加有纯化水的容器内，使之充分溶解制成溶液，搅拌均匀，分装而成。
5.根据权利要求1或3所述的羧甲基纤维素钠液体敷料，其特征是按照配方比例称重量（重量比）：羧甲基纤维素钠（CMC-Na）为0.5～20.00%，纯化水适量、防腐剂适量。
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Cited By (2)
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| CN115581798A (zh) * | 2022-11-01 | 2023-01-10 | 珠海市雅莎医疗器械有限公司 | 一种改善肤色暗沉的液体伤口敷料及其制备方法 |
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