CN110711048A

CN110711048A - Animal smoking and toxicant exposure device

Info

Publication number: CN110711048A
Application number: CN201910982591.XA
Authority: CN
Inventors: 郭衍俊; 何雪永; 郑楠; 夏海龙
Original assignee: Shanghai Tawang Intelligent Technology Co Ltd
Current assignee: Shanghai Tawang Intelligent Technology Co Ltd
Priority date: 2019-10-15
Filing date: 2019-10-15
Publication date: 2020-01-21

Abstract

The invention discloses an animal smoking and poisoning device, which comprises a smoking and exposing cabin, wherein one side of the smoking and exposing cabin is connected with a smoking machine through a gas pipe, the other side of the smoking and exposing cabin is connected with a waste gas purifier through a gas pipe, a pore plate is embedded in the middle position inside the smoking and exposing cabin, a mouse cage is respectively arranged at the position close to the bottom end inside the smoking and exposing cabin and the upper surface of the pore plate, a fan is arranged inside the smoking and exposing cabin and is positioned above the mouse cage, a controller is arranged on the upper surface of the smoking and exposing cabin, a sensor cabin is arranged on the side surface of the smoking and exposing cabin, a lead screw platform is arranged inside the smoking machine, and a position limiter is arranged at the position close to the upper surface of the lead screw platform; cigarette smoke can be automatically generated to enable animals to continuously inhale, and the method is suitable for establishing a COPD model of mice, rats and guinea pigs; the smoking frequency and the smoke amount can be controlled, and the smoke amount and the environmental indexes in the smoking cabin can be monitored in real time.

Description

Animal smoking and toxicant exposure device

Technical Field

The invention belongs to the technical field of animal smoking models, and particularly relates to an animal smoking and poisoning device.

Background

Chronic obstructive pulmonary disease is a common chronic respiratory disease whose etiology is associated with a chronic inflammatory response of the airways and lung tissue to harmful gases such as tobacco, or harmful particles. Recent research results show that the prevalence rate can reach 13.7% in people of 40 years and above. In rural areas in China, the death rate of respiratory diseases such as chronic obstructive pulmonary disease is the first cause of death of various diseases, and the death number of the respiratory diseases accounts for 21.46 percent of the total death number. As a disease with high disability rate and high fatality rate, the prevention and treatment of chronic obstructive pulmonary disease is always one of the key points of clinical basic research. An animal model which is consistent with the occurrence, development and pathological changes of clinical patients is established, and is the basis for researching the pathogenesis and treatment of chronic obstructive pulmonary disease;

the conventional means is to artificially ignite cigarettes and put the cigarettes into a mouse cage to generate smoke so as to enable animals to inhale, the mode cannot effectively control the smoke generation amount, various environmental indexes including smoke concentration are not monitored, and the animal model with high repeatability and good consistency is difficult to manufacture; the conventional means is time-consuming and labor-consuming due to the long molding period of several months; the smoke generated by the cigarette is directly exposed to the experimental environment, and the health of experimenters is affected.

Disclosure of Invention

The invention aims to provide an animal smoking and toxicant exposure device to solve the problems in the background technology.

In order to achieve the purpose, the invention provides the following technical scheme: an animal smoking and poisoning device comprises a smoking exposure cabin, wherein one side of the smoking exposure cabin is connected with a smoking machine through a gas pipe, the other side of the smoking exposure cabin is connected with a waste gas purifier through a gas pipe, a pore plate is embedded in the middle position inside the smoking exposure cabin, a mouse cage is installed on the position close to the bottom end and the upper surface of the pore plate inside the smoking exposure cabin, a fan is installed inside the smoking exposure cabin, the fan is located above the mouse cage, a controller is installed on the upper surface of the smoking exposure cabin, a sensor cabin is installed on the side surface of the smoking exposure cabin, a lead screw platform is installed inside the smoking machine, a limiter is installed on the upper surface of the lead screw platform near the position of the end part, a motor is installed at one end of the lead screw platform far away from the limiter, a smoke pushing rod is connected to the upper surface of the lead screw platform, a smoke storage rack is installed inside the smoking machine, and the cigarette pushing rod penetrates through the bottom of the cigarette storage frame, cigarettes are stored in the cigarette storage frame, and a cigarette lighting mechanism is installed at one end of the smoking machine.

Preferably, the cigarette lighting mechanism comprises a cigarette smoke chamber which is arranged at one end, close to the cigarette, of the cigarette smoking machine, a cigarette lighter is arranged on the side face of the cigarette smoke chamber, an air inlet is arranged on the side face of the cigarette smoke chamber, and a cigarette outlet is arranged at the top end of the cigarette smoke chamber.

Preferably, the outer wall of the smoking exposure cabin is made of transparent materials, and the fan blows air for mixing smoke.

Preferably, the sensor compartment monitors temperature, humidity, oxygen, carbon dioxide, carbon monoxide, pressure, particulate matter concentration inside the smoke exposure compartment.

Preferably, the interior of the waste gas purifier is a double-layer filtering system combining liquid phase filtration and solid phase filtration.

Compared with the prior art, the invention has the beneficial effects that:

in the invention, the animal smoking modeling system is specially designed for COPD modeling, can automatically generate cigarette smoke to enable animals to continuously inhale, and is suitable for building repeatable and well-consistent COPD models of mice, rats and guinea pigs; the system can control the frequency of lighting, the continuous burning time of the cigarettes, the smoke flow and the continuous time of controllable smoking, and can monitor the smoke amount and the environmental indexes in the smoking cabin in real time, and has high automation degree and reliable performance.

Drawings

FIG. 1 is a schematic diagram of the structure of the present invention;

figure 2 is a schematic view of the internal structure of a smoking machine of the present invention.

In the figure: 1. a smoking machine; 2. a fan; 3. a smoking exposure cabin; 4. a controller; 5. a sensor pod; 6. an exhaust gas purifier; 7. a mouse cage; 8. a stopper; 9. a screw platform; 10. pushing the tobacco rod; 11. a cigarette storage rack; 12. a smoke outlet; 13. cigarettes; 14. a cigarette lighter; 15. a flue gas chamber; 16. an air inlet; 17. a motor; 18. an orifice plate.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Referring to fig. 1-2, the present invention provides a technical solution: an animal smoking and poisoning device comprises a smoking exposure cabin 3, one side of the smoking exposure cabin 3 is connected with a smoking machine 1 through a gas pipe, the other side of the smoking exposure cabin 3 is connected with a waste gas purifier 6 through a gas pipe, a pore plate 18 is embedded in the middle position inside the smoking exposure cabin 3, a mouse cage 7 is installed at the position close to the bottom inside the smoking exposure cabin 3 and the upper surface of the pore plate 18, a fan 2 is installed inside the smoking exposure cabin 3, the fan 2 is positioned above the mouse cage 7, a controller 4 is installed on the upper surface of the smoking exposure cabin 3, a sensor cabin 5 is installed on the side surface of the smoking exposure cabin 3, a lead screw platform 9 is installed inside the smoking machine 1, a position close to the upper surface of the lead screw platform 9 is provided with a limiter 8, one end of the lead screw platform 9 far away from the limiter 8 is provided with a motor 17, the upper surface of the lead screw platform 9 is connected with a smoke, the internally mounted of smoking machine 1 has the cigarette frame 11 that stores up, and pushes away cigarette pole 10 and pass the bottom that stores up cigarette frame 11, and the inside of storing up cigarette frame 11 is stored with cigarette 13, and some cigarette mechanisms are installed to the one end of smoking machine 1.

Wherein, the cigarette lighter mechanism includes the cigarette smoking machine 1 and is close to the flue gas chamber 15 that the one end of cigarette 13 was seted up, and the side-mounting of flue gas chamber 15 has cigar lighter 14, air inlet 16 has been seted up to the side of flue gas chamber 15, outlet 12 has been seted up on the top of flue gas chamber 15, it promotes the cigarette 13 that stores up the cigarette frame 11 least significant end through motor 17 drive cigarette pushing rod 10 and gets into inside flue gas chamber 15, at this moment cigar lighter 14 ignites cigarette 13, and air inlet 16 lets in the air, at this moment can make cigarette 13 burn out the cigarette, and cigarette 13 burns out the back, motor 17 action drive pushing rod 10 once more promotes the cigarette 13 that gets into again and store up the cigarette frame 11 bottom, accomplish to light cigarette 13 and go out.

Wherein, the outer wall of the fumigation exposure cabin 3 adopts transparent material, and the fan 2 blows the mixture that is used for the flue gas.

Wherein, the sensor chamber 5 monitors the temperature, humidity, oxygen, carbon dioxide, carbon monoxide, pressure, particulate matter concentration inside the smoking exposure chamber 3.

Wherein, the inside of the waste gas purifier 6 is a double-layer filtering system combining liquid phase filtering and solid phase filtering.

The working principle and the using process of the invention are as follows: the cigarette 13 at the lowest end of the cigarette storage rack 11 is driven to enter the cigarette chamber 15 by the cigarette pushing rod 10 driven by the motor 17, at the moment, the cigarette lighter 14 ignites the cigarette 13, the air inlet 16 is filled with air, at the moment, the cigarette 13 can be combusted to produce smoke, after the cigarette 13 is burnt out, the motor 17 acts again to drive the cigarette pushing rod 10 to push the cigarette 13 which enters the bottom of the cigarette storage rack 11 again, the cigarette 13 is continuously ignited to produce smoke, the smoke enters the interior of the smoke exposure cabin 3 along the air delivery pipe through the smoke outlet 12 and is respectively positioned in the upper chamber and the lower chamber which are separated from the pore plate 18, at the moment, an experimental mouse in the squirrel cage 7 can absorb the smoke, the fan 2 rotates to mix the smoke, the sensor cabin 5 monitors the temperature, the humidity, the oxygen, the carbon dioxide, the carbon monoxide, the pressure and the concentration of particulate matters in the smoke exposure cabin 3, at the moment, the survival situation of the, and finally, the flue gas enters the interior of the waste gas purifier 6 along the gas conveying pipe, is absorbed by the liquid filter and then is discharged after being adsorbed by the solid-phase filter.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. An animal smoking and toxicant exposure device comprises a smoking and exposing cabin (3), and is characterized in that: one side of the smoking exposure cabin (3) is connected with a smoking machine (1) through a gas pipe, the other side of the smoking exposure cabin is connected with a waste gas purifier (6) through a gas pipe, the internal middle position of the smoking exposure cabin (3) is embedded with a pore plate (18), the internal part of the smoking exposure cabin (3) is close to the bottom and the upper surface of the pore plate (18) is provided with a mouse cage (7), the internal part of the smoking exposure cabin (3) is provided with a fan (2), the fan (2) is arranged above the mouse cage (7), the upper surface of the smoking exposure cabin (3) is provided with a controller (4), the side surface of the smoking exposure cabin (3) is provided with a sensor cabin (5), the internal part of the smoking machine (1) is provided with a screw rod platform (9), the upper surface of the screw rod platform (9) is provided with a position limiter (8) close to the position, lead screw platform (9) are kept away from the one end of stopper (8) and are installed motor (17), the upper surface of lead screw platform (9) is connected with and is pushed away cigarette pole (10), the internally mounted of smoking machine (1) has stores up cigarette frame (11), just push away the bottom that cigarette pole (10) passed and store up cigarette frame (11), the inside storage that stores up cigarette frame (11) has cigarette (13), some cigarette mechanisms are installed to the one end of smoking machine (1).

2. The animal smoking and toxicant exposure device of claim 1, wherein: the cigarette lighting mechanism comprises a cigarette smoking machine (1), a cigarette smoke chamber (15) is formed in one end, close to a cigarette (13), of the cigarette smoking machine, a cigarette lighter (14) is installed on the side face of the cigarette smoke chamber (15), an air inlet (16) is formed in the side face of the cigarette smoke chamber (15), and a cigarette outlet (12) is formed in the top end of the cigarette smoke chamber (15).

3. The animal smoking and toxicant exposure device of claim 1, wherein: the outer wall of the fumigation exposure cabin (3) is made of transparent materials, and the fan (2) blows air for mixing smoke.

4. The animal smoking and toxicant exposure device of claim 1, wherein: the sensor cabin (5) monitors the temperature, humidity, oxygen, carbon dioxide, carbon monoxide, pressure and particulate matter concentration inside the fumigation exposure cabin (3).

5. The animal smoking and toxicant exposure device of claim 1, wherein: the interior of the waste gas purifier (6) is a double-layer filtering system combining liquid phase filtering and solid phase filtering.