CN110710994B - Tissue sampler - Google Patents
Tissue sampler Download PDFInfo
- Publication number
- CN110710994B CN110710994B CN201911097618.3A CN201911097618A CN110710994B CN 110710994 B CN110710994 B CN 110710994B CN 201911097618 A CN201911097618 A CN 201911097618A CN 110710994 B CN110710994 B CN 110710994B
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- Prior art keywords
- sampling
- tissue
- arc part
- cutting
- arc
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- 238000005070 sampling Methods 0.000 claims abstract description 112
- 238000010008 shearing Methods 0.000 claims abstract description 8
- 230000000149 penetrating effect Effects 0.000 claims abstract description 3
- 238000001574 biopsy Methods 0.000 abstract description 33
- 230000002093 peripheral effect Effects 0.000 abstract description 4
- 230000035876 healing Effects 0.000 abstract description 3
- 210000001519 tissue Anatomy 0.000 description 77
- 238000000034 method Methods 0.000 description 7
- 230000009286 beneficial effect Effects 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 238000003306 harvesting Methods 0.000 description 3
- 210000001185 bone marrow Anatomy 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 210000004872 soft tissue Anatomy 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000002380 cytological effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000001861 endoscopic biopsy Methods 0.000 description 1
- 238000012333 histopathological diagnosis Methods 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000013188 needle biopsy Methods 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/0233—Pointed or sharp biopsy instruments
- A61B10/0266—Pointed or sharp biopsy instruments means for severing sample
- A61B10/0275—Pointed or sharp biopsy instruments means for severing sample with sample notch, e.g. on the side of inner stylet
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medical Informatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
A tissue sampler comprises a sampling part, wherein the sampling part comprises a sampling sleeve, a sampling core rod and a sampling incision. The sampling sleeve has a longitudinal axis and a receiving cavity disposed along the longitudinal axis. The sampling core rod comprises a body, a distal end and a proximal end, wherein the body is arranged in the accommodating cavity, is in clearance fit with the accommodating cavity, and is used for operating the proximal end, so that the body can reciprocate in the accommodating cavity along the same trend of the longitudinal axis, and the distal end is positioned outside an opening at one end of the accommodating cavity and is used for penetrating tissues. The sampling incision is arranged on the side wall of the sampling sleeve and communicated with the accommodating cavity, and is used for shearing tissues. The tissue sampler provided by the invention can be used for performing directional biopsy sampling on target tissues, the damage caused by repeated stamping on peripheral tissues of the sampled target tissues is not needed, and the tissue healing time after biopsy operation is shortened.
Description
Technical Field
The invention relates to a medical instrument, in particular to an instrument for sampling tissues, which is beneficial to acquiring target tissues in biopsy operation and reducing the damage area of peripheral tissues.
Background
"Biopsy" refers to a technique of taking out a lesion tissue from a patient by incision, forceps, puncture, or the like, and performing pathological examination, in response to diagnosis and treatment. It is the most important part of the diagnosis pathology, and makes clear histopathological diagnosis for most of the inspection cases, and is used as the final diagnosis in clinic.
Biopsies are classified by sampling, such as: open biopsy (surgery), endoscopic biopsy (biopsy forceps), and percutaneous needle biopsy (biopsy needle); classification by sampling site, such as: soft tissue aspiration biopsy and bone tissue aspiration biopsy; classifying by inspection sample, such as: cytological biopsies and histological biopsies.
Patent CN201480065733.1 discloses a biopsy trocar for performing a safe, reliable and rapid bone marrow biopsy procedure. It comprises a biopsy needle with a cannula and a spindle with a shaft adapted to slide in the biopsy needle. The cannula has at its distal end at least one internal rib forming a helical portion on the inner wall of the cannula, the shaft having a helical groove capable of mating with the internal rib, the internal rib being adapted to retain a bone marrow sample in the needle.
Patent CN201510458019.5 discloses a replaceable coring biopsy needle that provides a specific cutting slot defined on one side of the distal portion of the needle. The side cutting slots are configured to collect tissue samples of the full core and to leave the full core intact. The biopsy needle configuration enables maximizing tissue sampling yield and further ensures cohesion of the collected sampled tissue.
In the clinical use of the biopsy needle, soft tissue cutting and acquisition are realized under the shearing action of the biopsy needle caused by the relative movement between the sampling mandrel and the sleeve in the sampling process. This approach requires repeated stabbing of the tissue and does not allow accurate sampling of the locally diseased tissue.
Disclosure of Invention
It is an object of the present invention to provide a tissue sampler for sampling tissue, which facilitates the acquisition of target tissue during biopsy procedures and reduces the lesion area of surrounding tissue.
It is another object of the present invention to provide a tissue sampler for use with an instrument for sampling tissue that increases the amount of tissue targeted for biopsy procedures while reducing the area of damage to surrounding tissue.
It is a further object of the present invention to provide a tissue sampler for use with an instrument for sampling tissue that reduces biopsy procedure time.
It is a further object of the present invention to provide a tissue sampler for use with an instrument for sampling tissue that shortens biopsy procedure time while increasing biopsy tissue sampling volume.
The invention provides a tissue sampler, which comprises a sampling part, wherein the sampling part comprises
A sampling cannula having a longitudinal axis and a receiving cavity disposed along the longitudinal axis;
The sampling core rod comprises a body, a distal end and a proximal end, wherein the body is arranged in the accommodating cavity, is in clearance fit with the accommodating cavity, and is operated to reciprocate along the same trend of the longitudinal axis in the accommodating cavity, and the distal end is positioned outside an opening at one end of the accommodating cavity and is used for penetrating tissues;
and the sampling incision is arranged on the side wall of the sampling sleeve and communicated with the accommodating cavity, and is used for shearing tissues.
In another embodiment of the tissue sampler, a sampling slot is provided in the sampling core. After the acquired tissue enters the sampling incision, the tissue is gathered in the sampling groove.
Another embodiment of the tissue sampler provides at least 2 sampling incisions, in particular 2 to 6 sampling incisions, on the side wall of the sampling cannula, such as: 2,3,4, 5, 6, etc. The sampling cuts are evenly distributed around the sidewall of the sampling sleeve.
The tissue sampler of the invention, the sampling incision comprises:
the collecting opening is arranged on the side wall of the sampling sleeve and is communicated with the accommodating cavity;
The cutting portion is connected with the side wall of the sampling sleeve and comprises a cutting end portion, an acquisition arc portion and a cutting arc portion, the cutting end portion is used for isolating the acquisition arc portion from the cutting arc portion, the cutting end portion is used for fixing tissues and cutting the tissues in cooperation with the edge of the acquisition opening, the acquisition arc portion guides the tissues fixed by the cutting end portion and enters the acquisition opening, the cutting end portion and the edge of the acquisition opening are convenient to cut the tissues, and the cutting arc portion is used for assisting the cutting end portion to cut.
Another embodiment of a sampling incision, the cutting arc is curved toward the collection opening, comprising a first arc, a second arc, and a third arc. Two ends of the second arc part are respectively connected with the first arc part and the second arc part, the first arc part is close to the cutting end part, and one end of the third arc part is arranged on the side wall of the sampling sleeve.
In another embodiment of the sampling incision, the radius of curvature of the first arc is 0.50mm + -0.02 mm, the radius of curvature of the second arc is 3.50mm + -0.02 mm, the radius of curvature of the third arc is 6.80mm + -0.02 mm, the three arcs cooperate with one another to sequentially assist in tissue fixation, guiding harvested tissue into the harvesting opening and preventing outward leakage of tissue into the harvesting opening.
In another embodiment of the sampling incision, the ratio of the radius of curvature of the cutting arc to the radius of curvature of the sidewall of the sampling cannula is 1.45-1. When the ratio of the radius of curvature of the cutting arc to the radius of curvature of the sidewall of the sampling sleeve is 1, it will be appreciated that the cutting arc is a portion of the sidewall of the sampling sleeve.
The technical scheme of the invention has the beneficial effects that:
The tissue sampler provided by the invention can be used for performing directional biopsy sampling on target tissues, the damage caused by repeated stamping on peripheral tissues of the sampled target tissues is not needed, and the tissue healing time after biopsy operation is shortened.
According to the tissue sampler provided by the invention, the sampling sleeve rotates relative to the body around the longitudinal axis of the sampling sleeve, so that the biopsy sampling is implemented in a sampling mode that the sampling incision shears target tissue, the biopsy operation time is obviously shortened by more than 50%, and the biopsy tissue sampling amount is improved by more than 1 time.
Drawings
FIG. 1 is a schematic diagram of an embodiment of a tissue sampler according to the present invention;
FIG. 2 is a schematic view of the tissue sampler of FIG. 1 with a sampling cannula at an angle;
FIG. 3 is a schematic radial view of another embodiment of a sampling cannula of the tissue sampler of the present invention;
FIG. 4 is a schematic view of an angle of a sampling core of the tissue sampler shown in FIG. 1.
Detailed Description
The technical scheme of the present invention is described in detail below with reference to the accompanying drawings. The embodiments of the present invention are only for illustrating the technical scheme of the present invention and not for limiting the same, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications and equivalents may be made thereto without departing from the spirit and scope of the technical scheme of the present invention, which is intended to be covered by the scope of the claims of the present invention.
Fig. 1 is a schematic structural view of an embodiment of a tissue sampler according to the present invention, fig. 2 is a schematic structural view of a sampling sleeve of the tissue sampler shown in fig. 1 at an angle, and fig. 4 is a schematic structural view of a sampling core bar of the tissue sampler shown in fig. 1 at an angle. As shown in fig. 1 to 4, the tissue sampler of the present embodiment includes a sampling portion 10, and the sampling portion 10 includes a sampling sleeve 100, a sampling core bar 200, and a sampling incision 300. The sampling cannula 100 has a longitudinal axis (not shown) and a receiving cavity 110 disposed along the longitudinal axis. The sampling core 200 includes a body 210, a distal end 220 and a proximal end 230, wherein the body 210 is disposed in the accommodating cavity 110, and is in clearance fit with the accommodating cavity 110, and the proximal end 230 is operated (or mounted on a cylinder or a piston), so that the body 210 reciprocates in the accommodating cavity 110 along the same direction of the longitudinal axis, and the distal end 220 is located outside the opening at one end of the accommodating cavity 110, which is beneficial to performing the puncturing operation on the target tissue during the biopsy operation. The body 210 is provided with a sampling slot 211 to accommodate the isolated tissue separated from the tissue and to increase the sampling amount of the tissue.
The sampling incision 300 is provided at the sidewall 120 of the sampling cannula and communicates with the receiving chamber 110. When the sampling incision 300 reaches the target tissue to be sampled, the sampling incision is sheared against the target tissue by rotating the sampling cannula 100 about its longitudinal axis relative to the body 210, and the resected tissue is passed into the sampling cannula through the sampling incision 300 and falls into and is held in the sampling slot 211. At least 2 sampling cuts 300 are provided in the sidewall 120 of the sampling sleeve, such as: but are not limited to, 2,3, 4,5, 6, etc. These sampling cuts 300 are evenly distributed around the sidewall 120 of the sampling sleeve.
FIG. 3 is a schematic radial view of another embodiment of a sampling cannula of the tissue sampler of the present invention. As shown in fig. 3, 2 sampling cuts 300 are provided around the sidewall 120 of the sampling sleeve. Each sampling incision includes a collection opening 310 and a cutting portion 320. The collection opening 310 is disposed on a sidewall of the sampling cannula and communicates with the receiving chamber 110.
Cutting portion 320 is connected to the sidewall of sampling sleeve 100 and includes a cutting end 321, a harvesting arc 330, and a cutting arc 340. The cutting end 321 isolates the collecting arc 330 from the cutting arc 340, and is used for fixing the target tissue to be sampled, and shearing the tissue in cooperation with the edge of the collecting opening 310, the collecting arc 330 guides the tissue fixed by the cutting end 321, so that the resected tissue enters the collecting opening 310, the edge of the collecting opening and the cutting end are convenient for shearing the tissue, the cutting arc 340 is used for assisting the cutting end 321 in shearing, and the ratio of the curvature radius of the cutting arc 340 to the curvature radius of the side wall 120 of the sampling sleeve is 1.45-1. In this embodiment, the ratio of the radius of curvature of the cutting arc 340 to the radius of curvature of the sidewall 120 of the sampling sleeve is 1, i.e. the cutting arc 340 is a portion of the sidewall 120 of the sampling sleeve.
To facilitate separation and sampling of the target tissue to be sampled, in this embodiment, the cutting arc 330 is curved toward the collection opening 310, which includes a first arc 331 (radius of curvature of 0.50mm + -0.02 mm), a second arc 332 (radius of curvature of 3.50mm + -0.02 mm), and a third arc 333 (radius of curvature of 6.80mm + -0.02 mm). The two ends of the second arc portion 332 are respectively connected with the first arc portion 331 and the second arc portion 333, the first arc portion 331 is adjacent to the cutting end 321, and one end of the third arc portion 333 is disposed on the side wall 120 of the sampling sleeve. The first arc part, the second arc part and the third arc part are mutually matched, and the auxiliary tissue fixation, the guiding of the collected tissue into the collecting opening and the outward sliding leakage of the tissue entering the collecting opening are sequentially implemented on the tissue.
The tissue sampler can perform directional biopsy sampling on target tissues, does not need to repeatedly stab peripheral tissues of the sampled target tissues to cause damage, and shortens tissue healing time after biopsy operation.
Claims (5)
1. A tissue sampler comprising a sampling portion, wherein said sampling portion comprises:
a sampling cannula having a longitudinal axis and a receiving chamber disposed along the longitudinal axis;
The sampling core rod comprises a body, a distal end and a proximal end, wherein the body is arranged in the accommodating cavity, is in clearance fit with the accommodating cavity, and is operated to reciprocate along the same trend of the longitudinal axis in the accommodating cavity, and the distal end is positioned outside an opening at one end of the accommodating cavity and is used for penetrating tissues;
the sampling incision is arranged on the side wall of the sampling sleeve and communicated with the accommodating cavity, and is used for shearing tissues;
the sampling incision comprises:
The collecting opening is arranged on the side wall of the sampling sleeve and is communicated with the accommodating cavity;
The cutting part is connected with the side wall of the sampling sleeve and comprises a cutting end part, a collecting arc part and a cutting arc part, the cutting end part is used for isolating the collecting arc part from the cutting arc part, the cutting end part is used for fixing tissues and shearing the tissues in cooperation with the edge of the collecting opening, the collecting arc part is used for guiding the tissues fixed by the cutting end part to enter the collecting opening, and the cutting arc part is used for assisting the cutting end part to shear the tissues;
The collecting arc part is bent towards the collecting opening and comprises a first arc part, a second arc part and a third arc part, two ends of the second arc part are respectively connected with the first arc part and the second arc part, the first arc part is close to the cutting end part, and one end of the third arc part is arranged on the side wall of the sampling sleeve;
the curvature radius of the first arc part is 0.50mm plus or minus 0.02mm, the curvature radius of the second arc part is 3.50mm plus or minus 0.02mm, and the curvature radius of the third arc part is 6.80mm plus or minus 0.02mm;
The sampling core rod is provided with a sampling groove, and when the acquired tissue enters the sampling incision, the tissue is gathered in the sampling groove.
2. The tissue sampler of claim 1, wherein at least 2 of said sampling cuts are provided in a sidewall of said sampling sleeve.
3. The tissue sampler of claim 1, wherein the number of sampling cuts is 2,3, 4,5 or 6 on the side wall of the sampling sleeve.
4. The tissue sampler of claim 1, wherein the ratio of the radius of curvature of the cutting arc to the radius of curvature of the side wall of the sampling cannula is 1.45-1.
5. The tissue sampler of claim 1, wherein the ratio of the radius of curvature of the cutting arc to the radius of curvature of the side wall of the sampling sleeve is 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911097618.3A CN110710994B (en) | 2019-11-11 | 2019-11-11 | Tissue sampler |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911097618.3A CN110710994B (en) | 2019-11-11 | 2019-11-11 | Tissue sampler |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110710994A CN110710994A (en) | 2020-01-21 |
| CN110710994B true CN110710994B (en) | 2024-08-06 |
Family
ID=69215855
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911097618.3A Active CN110710994B (en) | 2019-11-11 | 2019-11-11 | Tissue sampler |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110710994B (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1993081A (en) * | 2004-04-05 | 2007-07-04 | Hi-Lex株式会社 | Bone marrow collection method and medical device used in the method |
| CN102348418A (en) * | 2009-03-16 | 2012-02-08 | C·R·巴德公司 | Biopsy device having rotational cutting |
| CN211213272U (en) * | 2019-11-11 | 2020-08-11 | 浙江探针生物科技有限公司 | Tissue sampler |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030032895A1 (en) * | 2001-08-09 | 2003-02-13 | Fisher John S. | Dual action aspiration biopsy needle |
| US20090112119A1 (en) * | 2007-10-31 | 2009-04-30 | Kim Stanley I | Rotating biopsy device and biopsy robot |
| CN104540462B (en) * | 2012-06-14 | 2017-12-01 | 萨诺库里斯公司 | For creating the medical treatment device and component of passage in soft tissue |
| JP7036313B2 (en) * | 2018-02-01 | 2022-03-15 | 高島産業株式会社 | Biometer and biometer |
-
2019
- 2019-11-11 CN CN201911097618.3A patent/CN110710994B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1993081A (en) * | 2004-04-05 | 2007-07-04 | Hi-Lex株式会社 | Bone marrow collection method and medical device used in the method |
| CN102348418A (en) * | 2009-03-16 | 2012-02-08 | C·R·巴德公司 | Biopsy device having rotational cutting |
| CN211213272U (en) * | 2019-11-11 | 2020-08-11 | 浙江探针生物科技有限公司 | Tissue sampler |
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| Publication number | Publication date |
|---|---|
| CN110710994A (en) | 2020-01-21 |
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| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20200610 Address after: 314112 floor 1 and floor 2, building 1, No. 383, Huimin Avenue, Huimin street, Jiashan County, Jiaxing City, Zhejiang Province Applicant after: ZHEJIANG TANZHEN BIOTECHNOLOGY Co.,Ltd. Address before: 314112 Room 302, floor 3, building 2, No. 383, Huimin Avenue, Huimin street, Jiashan County, Jiaxing City, Zhejiang Province Applicant before: Jiashan Hongyu Technology Consulting Co.,Ltd. |
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