CN110693935A - Garcinia entrapped transdermal patch containing compound obtained by fermenting traditional Chinese medicine starch and fatty oleic acid and self-adhesive matrix and preparation method thereof - Google Patents

Abstract

The invention relates to a transdermal patch containing Garcinia cambogia containing a self-adhesive matrix obtained by fermentation of traditional Chinese medicine starch and fatty oleic acid, and a preparation method thereof. The drug-loaded compound containing traditional Chinese medicine starch and fatty oleic acid fermented The self-adhesive matrix is naturally fermented by traditional Chinese medicine starch, fatty oleic acid contained in Chinese medicine seeds, liquid solvent and dry yeast. The invention adopts the oil-water amphiphilic matrix with low melting point and self-adhesive property to encapsulate Garcinia cambogia, and the patch has excellent drug penetration performance, good adhesion performance, high drug loading capacity, good air permeability, no residue after peeling from the skin, etc. Advantage. The preparation process of the self-adhesive matrix transdermal patch containing Garcinia cambogia containing the compound obtained by fermentation of traditional Chinese medicine starch and fatty oleic acid is simple, free of environmental pollution and organic residue, and has the advantages of good drug dispersibility, good stability, and no It has the characteristics of skin irritation, high production efficiency and low cost.

Description

Self-adhesive base of compound containing Chinese medicinal starch and fatty oleic acid fermented with Garcinia cambogia Quality transdermal patch and preparation method

technical field

The invention belongs to the field of medicine, in particular to a transdermal patch containing a compound self-adhesive matrix obtained by fermentation of traditional Chinese medicine starch and fatty oleic acid containing Garcinia cambogia and a preparation method thereof.

Background technique

Garcinia cambogia is a commonly used traditional Chinese medicine with the functions of reducing swelling and fighting poison, dispelling rot and astringing sores. The stability and stability are poor. Tablets, capsules, oral liquids, and granules are commonly used in clinical practice, especially the gambogic acid injection prepared by dissolving borax solution. It is still difficult to overcome the problems of stability and safety. Topical administration is a good option for attenuating toxicity, and its R&D focus is on finding a suitable matrix that can improve its stability and dispersibility.

Traditional Chinese medicines such as pueraria, trichosandra, and turmeric are rich in starch. However, modern research pays more attention to the study of small molecules such as puerarin and volatile oil. Starch, as the main component of medicinal materials, is often discarded after the extraction of small molecules, resulting in waste of resources. Similar to this, seed Chinese medicines such as strychnine and senneem are rich in fatty oleic acid, but more attention is paid to ingredients such as strychnine and strychnine, and fatty oleic acid is often discarded. Therefore, the research and development of traditional Chinese medicine starch and traditional Chinese medicine fatty oleic acid as the matrix of external dosage forms is of great significance for the effective utilization of traditional Chinese medicine resources.

In this study, the internal hydrophobic groups and the external hydrophilic groups in traditional Chinese medicine starch were used to form starch-fatty oleic acid complexes with the hydrophobic groups of traditional Chinese medicine fatty oleic acid under special process conditions. The complex has a large hydrophobic cavity and strong hydrophilic properties, is a self-adhesive amphiphilic component, and has higher dissociation temperature and higher resistance to enzymatic hydrolysis. Therefore, the compound can be used to prepare a transdermal patch containing Garcinia cambogia in order to solve the above-mentioned problems. The agents all have good druggability. This research is an original innovation, and there is no similar research report so far.

SUMMARY OF THE INVENTION

The purpose of the present invention is to provide a kind of transdermal patch containing the self-adhesive matrix of the compound obtained by fermentation of Chinese medicine starch and fatty oleic acid containing Garcinia cambogia, and its preparation method, so as to overcome the defects of the prior art.

Specifically, the present invention provides a drug-loaded self-adhesive matrix containing a compound obtained by fermentation of traditional Chinese medicine starch and fatty oleic acid, and the matrix has self-adhesion and amphiphilicity.

The self-adhesive matrix of the described drug-containing Chinese medicine starch and fatty oleic acid fermentation compound is made up of the following components by weight:

Garcinia 1-10%;

Amphiphilic matrix with self-adhesive properties 90-99%;

Preferably, the self-adhesive matrix of the drug-loaded compound containing traditional Chinese medicine starch and fatty oleic acid fermentation is made up of the following components by weight:

Garcinia 2-6%;

Has a self-adhesive amphiphilic matrix 94-98%;

The self-adhesive matrix of the described medicine-loaded compound containing traditional Chinese medicine starch and fatty oleic acid fermentation is made by fermentation of the following components by weight:

Preferably, the self-adhesive matrix of the drug-loaded compound containing traditional Chinese medicine starch and fatty oleic acid fermentation is made by fermentation of the following components by weight:

The base has a melting point of 80°C-100°C, is semi-solid at normal temperature, and is liquid at high temperature.

Described traditional Chinese medicine starch is selected from one or more in pueraria starch, trichosandra, isatidis starch, turmeric starch, galangal starch;

Preferably, the traditional Chinese medicine starch is pueraria starch and turmeric starch, and its weight ratio is: kudzu starch: turmeric starch=1:1-1:3

Traditional Chinese medicine starch is a key component that affects the initial viscosity and hydrophilicity of the matrix, providing adhesion to the skin. Starch is insoluble in water, gelatinized, swelled and thickened after fermentation, and the prototype hydroxyl group can also form a complex with organic acids to form The cross-linked network structure increases the internal space of the hydrophobic group, so that the matrix has a high drug-carrying capacity, and produces initial adhesion and peel strength.

Described traditional Chinese medicine fatty oleic acid is selected from one or more in the kinds such as Neem, Sophora japonica, Amur Fructus, Datura Seed, Xanthium Fructus, Chuan Neem or strychnine; Compared with Neem fatty oleic acid and Sophora bean fatty oleic acid, it has the advantages of high acid value and good molding rate; strychnine fatty oleic acid has the advantages of high acid value and high oil content, and has good compatibility with traditional Chinese medicine starch. The advantages of increasing the drug loading while the adhesion force, therefore, it is preferable to use the strychnine fatty oleic acid and the Sichuan neem fatty oleic acid in combination. =1:1-1:3;

The dosage of the traditional Chinese medicine fatty oleic acid is 7-15 parts, preferably 9-12 parts, if the dosage is too small, the matrix viscosity is too large, it is difficult to peel off during the medication, and the garcinia is difficult to release; if the dosage is too much, the matrix The adhesiveness is insufficient, and the prepared transdermal patch cannot adhere to the skin.

The liquid solvent is a low-viscosity liquid at room temperature, which can reduce the cohesive strength of the traditional Chinese medicine starch, thicken the traditional Chinese medicine polysaccharide, provide a fermentation reaction environment, help to form a cross-linked network structure, and improve the softness and initial stage of the matrix. Viscous, which facilitates coating. The main liquid solvents that can be selected include honey, rice wine, rice vinegar, starch slurry, water, etc. The cost of honey and water is low and the skin irritation is small, so honey and water are preferred as the main liquid solvents, and the preferred weight ratio is: honey: water =1:0.5-1:1, the dosage of the main liquid solvent is 40-100 parts, preferably 60-100 parts, if the amount of the main liquid solvent is too small, the adhesiveness of the patch will be poor; The cohesion of the matrix layer is significantly reduced, which seriously affects the formability.

Dry yeast mainly provides the swelling degree of the matrix, and has the effect of promoting the chemical reaction between Chinese medicine starch and Chinese medicine fatty oleic acid. The optional dosage of the dry yeast is 2-5 parts, preferably 3-4 parts. If the amount of some yeast is too small, the consistency of the matrix is poor, and the semi-solid state of the matrix cannot be guaranteed; if the amount of some yeast is too much, the acidity of the matrix is too strong, the irritation is strong, and the comfort when applied is poor.

Another object of the present invention is to provide the preparation method of the self-adhesive matrix of the described drug-containing Chinese medicine starch and fatty oleic acid fermentation compound, comprising the steps:

(1) after the starch-rich Chinese medicine roots or rhizomes are extracted, the extract residue insoluble in 60% ethanol is dried under reduced pressure and pulverized to obtain Chinese medicine starch;

(2) drying, crushing, and cold-pressing the seed Chinese medicine to obtain Chinese medicine fat Chinese medicine fatty oleic acid;

(3) Mix the traditional Chinese medicine starch, traditional Chinese medicine fat Chinese medicine fatty oleic acid, liquid solvent and dry yeast evenly, seal at 30°C for 2-5 hours, add Garcinia cambogia, mix well, seal at 30°C for 1-2 hours, and prepare a medicine-containing matrix; The substrate has a low softening point and coating temperature with good adhesion properties.

In the method for preparing the amphiphilic substrate with self-adhesive properties provided by the present invention, no organic solvent is used, so that environmental pollution can be avoided, and the method has the characteristics of energy saving and environmental protection. In the preparation process, by isolating the air and the fermentation reaction, the formation of complexes between traditional Chinese medicine starch and fatty oleic acid is promoted to avoid the occurrence of phase separation.

Another object of the present invention is to provide a transdermal patch containing a self-adhesive matrix of Garcinia cambogia containing a compound obtained by fermentation of traditional Chinese medicine and fatty oleic acid, which comprises a backing layer, a module layer, a drug-loaded traditional Chinese medicine-containing patch The self-adhesive matrix layer and the protective layer of the compound obtained from the fermentation of starch and fatty oleic acid; the module layer is covered on one side of the self-adhesive matrix layer of the drug-loaded compound containing traditional Chinese medicine starch and fatty oleic acid fermentation, and is composed of A medical rubber ring is formed, and the protective layer covers the other side of the self-adhesive matrix layer of the drug-loaded compound containing traditional Chinese medicine starch and fatty oleic acid fermentation;

The material of the self-adhesive matrix layer of the drug-loaded compound containing traditional Chinese medicine starch and fatty oleic acid fermentation is the self-adhesive matrix of the above-mentioned drug-loaded compound containing traditional Chinese medicine starch and fatty oleic acid fermentation.

The present invention also provides a kind of preparation method of the transdermal patch containing the self-adhesive matrix of the compound obtained from the fermentation of Chinese medicine starch and fatty oleic acid containing Garcinia cambogia, comprising the following steps:

(1) after the starch-rich Chinese medicine roots or rhizomes are extracted, the extract residue insoluble in 60% ethanol is dried under reduced pressure and pulverized to obtain Chinese medicine starch;

(2) drying, crushing, and cold pressing the seed Chinese medicine to obtain Chinese medicine fatty oleic acid;

(3) Mix the traditional Chinese medicine starch, traditional Chinese medicine fatty oleic acid, liquid solvent and dry yeast evenly, seal at 30°C for 2-5 hours, add Garcinia cambogia, mix evenly, seal at 30°C for 1-2 hours, and prepare a traditional Chinese medicine containing Garcinia cambogia The self-adhesive matrix of the complex obtained by fermentation of starch and fatty oleic acid;

(4) Heat the drug-containing substrate to 70-80°C, pour it into a medical rubber ring with a backing layer while it is still hot, dry under reduced pressure for 2-5 hours, cover with a protective layer, and package to obtain a packaged Garcinia Cambogia The transdermal patch containing the self-adhesive matrix of the compound obtained from the fermentation of traditional Chinese medicine starch and fatty oleic acid.

When the transdermal patch containing Garcinia Cambogia in the present invention is used, it can be attached to the skin of the patient's diseased part or acupuncture points, once a day, one patch each time, and the area is preferably 30-60 cm ² .

Since Garcinia cambogia is a compound with strong fat solubility, toxicity and poor stability, the present invention prepares it into a transdermal administration preparation, so that the drug can be released at the diseased site, thereby reducing the burden on the liver and kidney, and having good safety. The patch can be used continuously for 7 days, stably prolongs the release of the main drug Garcinia Cambogia, has long-term storage stability, excellent skin safety and suitable adhesion properties.

The beneficial effects of the present invention

The invention adopts the oil-water amphiphilic matrix with low melting point and self-adhesive property to encapsulate Garcinia cambogia, and the patch medicine has excellent transdermal performance, good adhesion performance, high drug loading capacity, good air permeability and no residue when peeled off from the skin. The preparation process of the self-adhesive matrix transdermal patch containing Garcinia cambogia containing the compound obtained by fermentation of traditional Chinese medicine starch and fatty oleic acid in the present invention is simple, free of environmental pollution and organic residue, and has the advantages of good drug dispersibility, good stability, and no Skin irritation, high production efficiency and low cost.

Description of drawings

Figure 1, Figure 2: Cumulative release curve of gambogic acid;

Figure 3: Cumulative throughput of gambogic acid per unit area.

Detailed ways

Example 1

Preparation of the amphiphilic matrix with self-adhesive properties:

Wash the fresh pueraria rhizomes or tubers, cut into pieces, squeeze the juice, homogenize and filter, let stand for 1-2 hours, and discard the supernatant. The starch layer was repeatedly washed and soaked with 60% ethanol until the supernatant was colorless, the starch layer was suspended in water, centrifuged to obtain a white starch layer, dried, pulverized, and used for later use;

The strychnine is dried, crushed and cold-pressed to obtain strychnine fatty oleic acid for use;

Take 100g of pueraria starch, 14g of strychnine fatty oleic acid, 380g of honey, 100g of water, and 2g of dry yeast, keep stirring quickly, mix well, seal at 30°C for 2-5h, add 20g of Garcinia cambogia, mix well, seal at 30°C 1-2h to form a uniform yellow transparent colloid.

The melting point of the prepared amphiphilic matrix with self-adhesive properties was determined to be 67 °C.

Example 2

Preparation of the amphiphilic matrix with self-adhesive properties:

After the turmeric root or rhizome is extracted, the extract residue insoluble in 60% ethanol is dried under reduced pressure and pulverized to obtain turmeric starch;

drying, crushing, and cold-pressing the Fructus Fructus Fructus to obtain Fructus Fructus Fructus;

Mix 100g turmeric starch, 15g fat oleic acid from Sichuan neem, 150g honey and 2g dry yeast, seal at 30°C for 2-5h, add 20g Garcinia cambogia, mix well, seal at 30°C for 1-2h to make a drug-containing matrix , the substrate has a lower softening point and coating temperature, and good adhesion properties.

The melting point of the prepared amphiphilic matrix with self-adhesive properties was determined to be 58 °C.

Example 3

Preparation of common substrates in which both traditional Chinese medicine starch and fatty oleic acid are not fermented by dry yeast:

Wash the fresh pueraria rhizomes or tubers, chop them, squeeze the juice, homogenize and filter, let stand for 1-2 hours, and discard the supernatant. The starch layer was repeatedly washed and soaked with 60% ethanol until the supernatant was colorless, the starch layer was suspended in water, centrifuged to obtain a white starch layer, dried, pulverized, and used for later use;

The strychnine is dried, crushed and cold-pressed to obtain the strychnine fatty oleic acid, which is ready for use;

Take 100g of pueraria starch, 14g of strychnine fatty oleic acid, 380g of honey, 100g of water, keep stirring rapidly, mix well, seal at 30°C for 2-5h, add 20g of Garcinia cambogia, mix well, seal at 30°C for 1-2h, To form a uniform yellow transparent colloid, that is.

Example 4

Preparation of traditional Chinese medicine starch fermentation substrate:

Wash the fresh pueraria rhizomes or tubers, cut into pieces, squeeze the juice, homogenize and filter, let stand for 1-2 hours, and discard the supernatant. The starch layer was repeatedly washed and soaked with 60% ethanol until the supernatant was colorless, the starch layer was suspended in water, and centrifuged to obtain a white starch layer, which was dried, pulverized, and used for later use;

Take 100g of kudzu starch, 380g of honey, 100g of water, and 2g of dry yeast, keep stirring quickly, mix well, seal at 30°C for 2-5h, add 20g of Garcinia cambogia, mix well, seal at 30°C for 1-2h, until a uniform shallow A yellow transparent colloid is obtained.

Example 5

Preparation of traditional Chinese medicine fatty oleic acid fermentation substrate:

The strychnine is dried, crushed and cold-pressed to obtain the strychnine fatty oleic acid, which is ready for use;

Take 14g of strychnine fatty oleic acid, 2g of dry yeast, 380g of honey, and 100g of water, keep stirring quickly, mix evenly, seal at 30°C for 2-5h, add 20g of Garcinia cambogia, mix well, seal at 30°C for 1-2h, That's it.

Example 6

Preparation of drug-loaded self-adhesive matrix containing traditional Chinese medicine starch and fatty oleic acid fermentation compound:

After the turmeric root or rhizome is extracted, the extract residue insoluble in 60% ethanol is dried under reduced pressure and pulverized to obtain turmeric starch;

drying, crushing, and cold-pressing the Fructus Fructus Fructus to obtain Fructus Fructus Fructus;

Mix 300g turmeric starch, 45g fat oleic acid from senneem, 450g honey and 6g dry yeast, seal at 30°C for 2-5h, add Garcinia cambogia, mix well, seal at 30°C for 1-2h to make a drug-containing matrix, That's it.

Example 7: Determination of Adhesion Properties

1. Determination of initial adhesive force: The initial adhesive force of the patch was measured by the probe method.

Remove the protective layer of the test patch, paste it on a clean test board, the dynamometer probe descends at a speed of 300mm·min ^-1 , and leaves after contacting the surface of the patch for 3s, and records that the probe leaves the patch surface. The maximum force at the time was measured 6 times continuously, and the average value was taken. The experimental results are shown in Table 1.

2. Determination of sticking force: stick the patch on a test plate placed vertically, and measure it with a sticking force tester.

Remove the protective layer of the test patch, parallel to the longitudinal direction of the plate, and paste it on the middle of the adjacent clean stainless steel test plate and stainless steel loading plate. Roll back and forth at a speed to ensure that there are no air bubbles in the bond. After standing at room temperature for 20min, fix it vertically on the test stand, hang a certain mass of weight along the length of the patch, and record the time when the patch falls off. Continuous measurement 6 times, take the average value, the experimental results are shown in Table 1.

3. Determination of peel strength: The peel strength of the patch was measured by a 180° peel test.

Cut the test patch to a size of 10cm×2cm, peel off the protective layer, and stick it on a clean stainless steel plate. Adhere the adhesive layer of the patch to the clean polyester film at the end, and use a pressure roller to stick it. Roll back and forth at the speed of (300±10)mm/min on the adhesive to ensure that there are no air bubbles in the bonding place. Place at room temperature for 20-40min, clamp the film and stainless steel plate up and down on the peel tester respectively, peel off continuously at (300±10) mm/min, and record the peel strength of the patch. Continuous measurement 6 times, take the average value, the experimental results are shown in Table 1.

Table 1 Test results of adhesion performance of different substrates in each group

(Note: * represents p < 0.05 compared with the unfermented matrix of traditional Chinese medicine starch and fatty oleic acid, and there is a significant difference in initial adhesion, holding force and peel strength.

sexual differences)

Example 8: In vitro release test

Franz diffusion cell method was used, the upper chamber was the diffusion chamber, and the lower chamber was the receiving chamber. Remove the protective layer of the prepared patch, fix the module layer up and the drug-containing side down on the receiving cell of the FranZ diffusion cell, cover the upper half cell and clamp it with iron clips. Ultrasonic degassed release medium 60% ethanol solution was added to the receiving cell. The diffusion area was 3.14 cm ² , the receiving volume was 7 ml, the stirring speed was 250 r/min, and the temperature of the receiving liquid was controlled at (32±0.5) ℃. 1h, 2h, 4h, 6h, 8h, 10h, 12h, 14h, 24h, 48h, 72h, 96h, 120h, 144h and 168h after the start of the experiment, take out 5ml of the release medium (and supplement the same amount of fresh release medium at the same temperature) , directly inject the sample to determine the content of the representative component gambogic acid, and calculate the cumulative release rate Q%. Each group of experiments was performed in parallel 3 times. The cumulative release rate Q% of gambogic acid is shown in Figures 1 and 2.

Example 9: In vitro skin penetration test

Healthy nude mice with a body weight of (18±2) g were taken, reared for 24 hours, the skin surface was washed with normal saline, sacrificed by severed neck, the skin without damage was peeled off, the subcutaneous tissue and fat were carefully scraped off, washed with normal saline, and kept in a -20°C refrigerator. Save for backup. During the experiment, the prepared skin was taken out, thawed naturally and washed several times with physiological saline, and the skin was fixed on the diffusion cell with the stratum corneum facing upward, and 30% ethanol-physiological saline was used as the receiving solution. The cell has a built-in magnetic stirrer, the rotating speed is 300r/min, the area of the diffusion cell is 2cm ² , the total volume of the receiving cell is 7ml, the constant temperature (37±1) ℃ water bath, first equilibrate for 30min, replace the receiving liquid, and exhaust the air under the skin , the gauze absorbs the liquid on the surface of the skin. Remove the protective layer from the prepared patch, precisely scrape 2 g of the drug-containing matrix, and stick it tightly on the skin of the nude mice. At 24h, 48h, 72h, 96h, 120h, 144h, and 168h, 1ml was sampled from the receiving pool respectively, and the receiving solution of the same temperature and volume was supplemented. The sample was filtered through a 0.45 μm microporous membrane, and the subsequent filtrate was taken. The content of gambogic acid in the sample was determined by HPLC, and the cumulative permeation per unit area (μg/cm ² ) at each time point was calculated. Repeat the experiment 3 times, with the average The values are the experimental results, and the experimental results are shown in Table 2 and Figure 3.

Table 2 Results of in vitro transdermal tests of different matrix patches loaded with gambogic acid

(Note: * means p < 0.05 compared with the unfermented substrates of traditional Chinese medicine starch and fatty oleic acid, and the cumulative permeation amount per unit area at 24h, 48h, 72h, 96h, 120h, 144h, and 168h is comparable to that of unfermented traditional Chinese medicine starch and fatty oleic acid. There is a significant difference compared to the matrix)

Example 10: Stability test

1. Test method: After storing the transdermal patch containing Garcinia Cambogia in Example 1-6 at room temperature for 3 months, visually observe whether there is crystal precipitation on the appearance.

2. Test results: The patches of Examples 1-6 were observed to form crystals in Example 3, but no crystals were formed in other groups, indicating that the fermentation process enhanced the stability of the patches.

Example 11: Skin irritation test

1. Test method: 6 healthy rabbits of 2.8-3.0 kg were taken and equally divided into intact skin group and damaged skin group, and the back of the animals was depilated 24h before administration. Five pieces of the test drug (patches of Examples 1-2, 4-6, 10cm ² ) and control drugs (patches of Example 3, 10cm ² ) were respectively affixed to the test drug area and the back of the animal. The control drug area (50cm ² ) was applied once a day for 7 consecutive days. 24h after the last administration, the residues were removed with warm water and normal saline, and the erythema and edema at the application site of the test drug at 1h, 24h, 48h and 72h, as well as the recovery and time of the above changes were observed. Stimulus response scores and stimulus intensity evaluations were performed.

2. test result: the patch of embodiment 1-2, 4-6 is through rabbit skin irritation test, intact skin group and damaged skin group administration all have no irritation reaction, embodiment 3 causes the slight erythema of the application site and Edema.

Example 12: Skin Allergy Test

1. Test method: Take 30 healthy guinea pigs of 250g-300g and divide them into three groups on average, 10 in each group, half male and half male. The left (sensitized) or right (excited) back of the guinea pigs was shaved 24 hours before administration, and the hair removal area was about 4×4 cm on each side. The test drug (the patch of Example 1-2, 4-6, 10cm ² ) was attached to the first group, the negative control drug (the patch of Example 3, 10 cm ² ) was attached to the second group, and the third group was attached to each side Positive sensitizer, 0.2ml of 1% ethanol solution of 2,4-dinitrochlorobenzene.

Sensitization: Take the test drug (patches of Examples 1-2, 4-6, 10cm ² ) and stick it on the outer layer of the left depilation area of the animal, fix it with an adhesive plaster, and remove the test drug after 6 hours. The same method was repeated on days 7 and 14. The methods of the negative control group (Example 3) and the positive control group (2,4-dinitrochlorobenzene) were the same as the test drug group.

Challenge: 14 days after the last sensitization, the test drug was applied to the outer layer of the hair removal area on the right side of the animal, fixed with an adhesive plaster, and the test drug was removed after 6 hours, and observed immediately, and then the skin was observed again at 24h, 48h, and 72h Allergic reaction. The methods of the negative control group (Example 3) and the positive control group (2,4-dinitrochlorobenzene) were the same as those of the tested drug group.

Allergic reaction scores and allergic intensity evaluations were performed on the test results of each animal.

2. Test results: The patches of Examples 1-6 were tested by guinea pig skin allergy test, and no obvious allergic reaction was found.

The preferred embodiments of the present invention have been described above, but are not intended to limit the present invention. Modifications and variations of the embodiments disclosed herein may be made by those skilled in the art without departing from the scope and spirit of the invention.

Claims (10)

1. a drug-loaded self-adhesive matrix containing traditional Chinese medicine starch and fatty oleic acid fermentation gained compound, is characterized in that, is made up of the component of following weight percent: Garcinia 1-10%; 90-99% of the self-adhesive matrix containing the compound obtained by fermentation of traditional Chinese medicine starch and fatty oleic acid. 2. the self-adhesive matrix containing traditional Chinese medicine starch and fatty oleic acid fermentation gained compound of drug loading according to claim 1, is characterized in that, is made up of the component of following weight percent: Garcinia 2-6%; Self-adhesive matrix containing 94-98% of the compound obtained by fermentation of traditional Chinese medicine starch and fatty oleic acid. 3. according to the self-adhesive matrix of the compound that contains Chinese medicine starch and fatty oleic acid fermentation gained according to claim 1 and 2, it is characterized in that, the described self-adhesive matrix that contains Chinese medicine starch and the compound obtained by fermentation of fatty oleic acid , is made through fermentation by the component of following parts by weight:

4. the self-adhesive matrix containing the compound obtained from the fermentation of traditional Chinese medicine starch and fatty oleic acid according to claim 3, is characterized in that, the described self-adhesive matrix containing the compound obtained from the fermentation of traditional Chinese medicine starch and fatty oleic acid is composed of The components of following parts by weight are formed through fermentation:

5. according to the self-adhesive matrix of the compound obtained by the fermentation of Chinese medicine starch and fatty oleic acid of the medicine-carrying according to claim 3, it is characterized in that, the self-adhesion of the compound of the compound obtained by the fermentation of Chinese medicine starch and fatty oleic acid of the medicine-carrying The matrix has self-adhesive oil-water amphiphilicity, the melting point of the matrix is 80°C-100°C, and it is semi-solid at normal temperature and liquid at high temperature. 6. the self-adhesive matrix containing traditional Chinese medicine starch and fatty oleic acid fermentation gained compound according to claim 3, it is characterized in that, described traditional Chinese medicine starch is selected from Pueraria lobata starch, Trichosanthes, Radix Isatidis starch, curcuma starch, Gao Liang One or more of ginger starch; Described traditional Chinese medicine fatty oleic acid is selected from one or more in Neem, Sophora japonica, Amur Fructus, Datura, Xanthium, Chuan Neem or Strychni; The liquid solvent is selected from one or more of honey, rice wine, rice vinegar, starch slurry and water. 7. the self-adhesive matrix containing traditional Chinese medicine starch and fatty oleic acid fermentation gained compound of drug-carrying according to claim 6, is characterized in that, described Chinese medicine starch is pueraria starch and Radix curcumae, and its weight ratio is: pueraria starch : Turmeric starch=1:1-1:3; Described traditional Chinese medicine fatty oleic acid is strychnine and Fructus Fructus, and its weight ratio is: Fructus Fructus: Fructus Fructus=1:0.5-1:1; The liquid solvent is honey and water, and the weight ratio is: honey: water=1:0.5-1:1. 8. the self-adhesive matrix containing the compound obtained from the fermentation of traditional Chinese medicine starch and fatty oleic acid for carrying medicine according to claim 7, is characterized in that, the mass ratio of traditional Chinese medicine starch and fatty oleic acid is 2:1-3:1. 9. A transdermal patch containing the self-adhesive matrix of Chinese medicine starch and fatty oleic acid fermentation gained compound containing Garcinia cambogia, is characterized in that, comprises backing layer, module layer, medicine-loaded containing Chinese medicine starch and fat A self-adhesive matrix layer and a protective layer of the compound obtained by oleic acid fermentation; the module layer is covered on one side of the self-adhesive matrix layer of the drug-loaded compound containing traditional Chinese medicine starch and fatty oleic acid fermentation, and is formed by a medical rubber ring. composition, the protective layer covers the other side of the self-adhesive matrix layer of the drug-loaded compound containing traditional Chinese medicine starch and fatty oleic acid fermentation; The material of the self-adhesive matrix layer of the drug-loaded compound containing traditional Chinese medicine starch and fatty oleic acid fermentation is the self-adhesive matrix layer of the drug-loaded compound containing traditional Chinese medicine starch and fatty oleic acid fermentation according to any one of claims 1-8. sticky base. 10. the method for preparing the self-adhesive matrix transdermal patch of the compound containing Chinese medicine starch and fatty oleic acid fermentation gained compound containing Garcinia Cambogia as claimed in claim 9, is characterized in that, comprises the steps: (1) after the starch-rich Chinese medicine roots or rhizomes are extracted, the extract residue insoluble in 60% ethanol is dried under reduced pressure and pulverized to obtain Chinese medicine starch; (2) drying, crushing, and cold pressing the seed Chinese medicine to obtain Chinese medicine fatty oleic acid; (3) Mix the traditional Chinese medicine starch, traditional Chinese medicine fatty oleic acid, liquid solvent and dry yeast evenly, seal at 30°C for 2-5 hours, add Garcinia cambogia, mix evenly, seal at 30°C for 1-2 hours, and prepare a traditional Chinese medicine containing Garcinia cambogia The self-adhesive matrix of the complex obtained by fermentation of starch and fatty oleic acid; (4) heating the drug-loaded self-adhesive matrix of the compound obtained by fermentation of traditional Chinese medicine starch and fatty oleic acid to 70-80 ° C, pouring it into a medical rubber ring with a backing layer while it is still hot, and drying under reduced pressure for 2- 5h, covered with a protective layer and packaged to obtain a transdermal patch containing a self-adhesive matrix of Garcinia cambogia containing a compound obtained by fermentation of traditional Chinese medicine starch and fatty oleic acid.

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