CN110652464A

CN110652464A - Antibacterial detergent and preparation method thereof

Info

Publication number: CN110652464A
Application number: CN201810696820.7A
Authority: CN
Inventors: 孙迎; 徐奇清; 焦晓军; 寇贺红; 江国亮
Original assignee: Foshan Nanhai Eastern Along Pharmaceutical Co Ltd
Current assignee: Foshan Nanhai Eastern Along Pharmaceutical Co Ltd
Priority date: 2018-06-29
Filing date: 2018-06-29
Publication date: 2020-01-07

Abstract

The invention relates to an antibacterial detergent and a preparation method thereof. The detergent comprises the following raw material components in percentage by weight: 0.1-20% of miconazole nitrate, 0.1-20% of chlorhexidine gluconate, 0.1-5% of thymol, 0.005-5% of antioxidant, 1-50% of surfactant, 0.001-0.01% of preservative, 1-10% of conditioner, 1-50% of transdermal agent, 0-5% of pH regulator and 45-90% of diluent. The antibacterial detergent has the advantages of good effects of clean decontamination, softness, moistening and easiness in cleaning, has an antibacterial effect, is used for pet cleaning, and can simultaneously achieve the functions of pet cleaning and prevention and treatment of pet skin diseases.

Description

Antibacterial detergent and preparation method thereof

Technical Field

The invention relates to the technical field of veterinary disinfection detergents, in particular to an antibacterial detergent and a preparation method thereof.

Background

With the improvement of the living standard of cities and the continuous change of the composition of family population, more and more families for feeding dogs and cats keep the lives of pets and people close.

However, pet skin diseases such as dermatitis, pain and itch, pathological depilation and the like of pets such as dogs and cats always bother the pet breeding owners, and germs carried by pet fur are more direct threats to human health. The skin diseases of dogs and cats are chronic contact infectious diseases caused by a series of organic lesions of skin due to excessive adhesion, propagation and invasion of pathogenic bacteria on the body surface of animals into keratinized tissues of skin, fur and toes, and are specifically characterized in that depilatory round spots with obvious boundaries appear on the skin, potential skin injury is caused, and symptoms such as exudates, scales or knots, pruritus and the like are accompanied. The disease has long course, is difficult to cure and easy to recur, and can be mutually transmitted among animals and between people and animals, thereby causing public health problems to a certain extent.

The dermatosis of pets is easy to relapse after treatment due to long-term and repeated attack of the dermatosis, and has certain side effect after long-term oral administration. At present, the general skin diseases are treated by applying a topical treatment medicament. Although the local application has better curative effect, the canine and the feline need to be applied after shaving because the hair is more, the operation is very inconvenient, and the beauty of the pet is seriously influenced after shaving.

At present, a pet detergent with a certain antibacterial effect is used for cleaning pets to achieve the antibacterial effect, so that the pet detergent plays a certain role in preventing and treating skin diseases of the pets. However, the current pet detergents are few in types and poor in antibacterial effect.

Disclosure of Invention

Therefore, an antibacterial detergent which not only has good detergency, but also has antifungal and antibacterial effects is needed.

The antibacterial detergent is prepared from the following raw materials in percentage by weight: 0.1-20% of miconazole nitrate, 0.1-20% of chlorhexidine gluconate, 0.1-5% of thymol, 0.005-5% of antioxidant, 1-50% of surfactant, 0.001-0.01% of preservative, 1-10% of conditioner, 1-50% of transdermal agent, 0-5% of pH regulator and 45-90% of diluent.

The antibacterial detergent selects miconazole nitrate, chlorhexidine gluconate and thymol with antifungal and antibacterial effects to be combined with the surfactant in an optimized proportion, and is matched with a proper amount of conditioner, transdermal agent, pH regulator and diluent, so that the antibacterial detergent has good decontamination cleanliness, has an antibacterial effect and is used for cleaning pets, and can simultaneously achieve the functions of cleaning pets and preventing and treating pet skin diseases.

In one embodiment, the detergent comprises the following raw material components in percentage by weight: 0.1-5% of miconazole nitrate, 0.1-5% of chlorhexidine gluconate, 0.1-2% of thymol, 0.005-0.5% of antioxidant, 1-30% of surfactant, 0.001-0.01% of preservative, 1-5% of conditioner, 1-15% of transdermal agent, 0.1-3% of pH regulator and 45-90% of diluent.

In one embodiment, the surfactant is selected from at least one of coconut diethanolamide, polyquaternium-7, sodium fatty alcohol polyoxyethylene ether sulfate, and cocamidopropyl betaine.

In one embodiment, the surfactant is coconut oil fatty acid diethanolamide and cocamidopropyl betaine, and the weight ratio of the coconut oil fatty acid diethanolamide to the cocamidopropyl betaine is (1-2): 1.

In one embodiment, the antioxidant is selected from at least one of tocopherol, butylated hydroxyanisole, butylated hydroxytoluene, and tertiary butyl hydroquinone.

In one embodiment, the conditioning agent is at least one selected from the group consisting of methyl silicone oil, ethyl silicone oil, phenyl silicone oil, methyl hydrogen silicone oil, methyl phenyl silicone oil, methyl chlorophenyl silicone oil, methyl ethoxy silicone oil, methyl trifluoropropyl silicone oil, methyl hydroxy silicone oil, ethyl hydrogen silicone oil, hydroxy hydrogen silicone oil, and cyanogen-containing silicone oil.

In one embodiment, the transdermal agent is selected from at least one of isopropyl myristate, dimethyl sulfoxide, decyl methyl sulfoxide, and laurocapram.

In one embodiment, the detergent further comprises 0.1-2% of a thickening agent and/or 0.01-2% of essence by weight percentage.

In one embodiment, the detergent comprises the following raw material components in percentage by weight: 1 to 3 percent of miconazole nitrate, 1 to 3 percent of chlorhexidine gluconate, 0.5 to 2 percent of thymol, 0.01 to 0.05 percent of dibutyl hydroxy toluene, 6 to 15 percent of cocamidopropyl betaine, 3 to 8 percent of coconut fatty acid diethanolamide, 2 to 8 percent of dimethyl sulfoxide, 2 to 6 percent of isopropyl myristate, 0.001 to 0.01 percent of methyl isothiazolinone, 1 to 4 percent of methyl silicone oil, 0.5 to 2 percent of citric acid, 0.1 to 0.5 percent of thickening agent, 0.1 to 0.5 percent of essence and the balance of water.

In addition, the application also provides a preparation method of the antibacterial detergent, and the preparation method comprises the following steps:

the components are uniformly mixed according to the formula of the detergent.

The preparation method has the advantages of mild reaction conditions, simple and safe operation, simple required equipment, stable quality of the obtained product and easy industrial production.

Detailed Description

In order that the invention may be more fully understood, a more particular description of the invention will now be rendered by reference to specific embodiments thereof that are illustrated in the appended drawings. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.

The antibacterial detergent is prepared from the following raw materials in percentage by weight: 0.1-20% of miconazole nitrate, 0.1-20% of chlorhexidine gluconate, 0.1-5% of thymol, 0.005-5% of antioxidant, 1-50% of surfactant, 0.001-0.01% of preservative, 1-10% of conditioner, 1-50% of transdermal agent, 0-5% of pH regulator and 45-90% of solvent.

Miconazole nitrate has excellent antibiotic effect on various fungi, such as candida albicans, aspergillus, cryptococcus neoformans, blastomyces, coccidioidomycosis, pseudosaccharomycete, saccharomycete, etc. and also has antibiotic effect on gram-positive coccus and bacillus. Chlorhexidine gluconate can kill bacteria by inhibiting adenosine triphosphate combined with cell membrane, destroying cell membrane to precipitate cell content, and reducing microbial contamination of skin and other active tissues; and still have antibacterial activity in pustular and necrotic tissue, and do not stimulate or interfere with the group's strong normal healing process. Thymol (thymol), also known as thymol, is an isomer of carvacrol, known as 2-isopropyl-5-methylphenol, having the chemical formula C₁₀H₁₂H₂O, molecular mass 150.22. It not only has strong acaricidal action, but also has antibacterial, anti-inflammatory and antioxidant effects.

Because pets such as dogs and cats have thick hair and much grease, the detergent for pets needs to have excellent detergency, and in order to make the detergent have good detergency and excellent resistance to the skin of dogs and cats, the detergent needs to contain more surfactant, but the surfactant at a higher concentration in the detergent usually inhibits the antibacterial effect of the antibacterial component. The inventor of the application creatively applies the combination of thymol, miconazole nitrate and chlorhexidine gluconate to the detergent for pets through a large number of experiments to enhance the antibacterial effect, optimizes the proportion of each component to enable the components to play a role in cooperation, and the obtained antibacterial detergent has the characteristics of good detergency and antibacterial effect, softness, moisture and easiness in cleaning.

The antibacterial detergent selects miconazole nitrate and chlorhexidine gluconate as antibacterial components to be compounded with a surfactant with a cleaning effect and optimizes the formula combination, thymol is matched to play a role in antibacterial synergism, and a proper amount of conditioner and transdermal agent are matched to ensure that the antibacterial detergent has good decontamination cleanliness, is soft and moist and is easy to clean, has an antibacterial and antibacterial effect, can be used for cleaning pets, and achieves the functions of cleaning pets and preventing and treating pet skin diseases.

It will be appreciated that thymol may be added to the detergent in purified form; alternatively, thyme oil or thyme extract containing thymol may be added to the detergent while ensuring that thymol is present at the desired concentration in the detergents of the present application. Thyme oil or thyme extract is obtained from the thyme plant.

In one embodiment, the paint comprises the following raw material components in percentage by weight: 0.1-5% of miconazole nitrate, 0.1-5% of chlorhexidine gluconate, 0.1-2% of thymol, 0.005-0.5% of antioxidant, 1-30% of surfactant, 0.001-0.01% of preservative, 1-5% of conditioner, 1-15% of transdermal agent, 0.1-3% of pH regulator and 45-90% of diluent.

Specifically, the surfactant may be selected from nonionic surfactants such as polyoxyethylene type and polyhydric alcohol type, cationic surfactants such as amine salt type, quaternary ammonium salt type, heterocyclic type and rhamsonium salt type, anionic surfactants such as fatty acid salt, iodate, sulfate and phosphate salt, and amphoteric surfactants such as amino acid type, betaine type, imidazoline type and zwitterionic amine oxide type.

Preferably, the surfactant is selected from at least one of coconut diethanolamide, polyquaternium-7, sodium fatty alcohol polyoxyethylene ether sulfate and cocamidopropyl betaine.

The surfactant has solubilizing, thickening, decontaminating and degreasing effects, has excellent foaming capacity and foam stability, has a certain moisturizing effect, and can prevent skin from drying and peeling.

More preferably, the surfactant is a combination of coconut oil fatty acid diethanolamide and cocamidopropyl betaine, and the weight ratio of the coconut oil fatty acid diethanolamide to the cocamidopropyl betaine is (1-2): 1.

In one embodiment, the antioxidant is selected from at least one of tocopherol, butylated hydroxyanisole, butylated hydroxytoluene, and tertiary butyl hydroquinone. It will be appreciated that the addition of an antioxidant prevents or retards oxidation and improves the stability of the system.

Preferably, the antioxidant is dibutylhydroxytoluene.

In one embodiment, the conditioner is silicone oil conditioner, and specifically at least one of methyl silicone oil, ethyl silicone oil, phenyl silicone oil, methyl hydrogen-containing silicone oil, methyl phenyl silicone oil, methyl chlorophenyl silicone oil, methyl ethoxy silicone oil, methyl trifluoropropyl silicone oil, methyl hydroxy silicone oil, ethyl hydrogen-containing silicone oil, hydroxy hydrogen-containing silicone oil, and cyanogen-containing silicone oil can be selected. The conditioner can form a protective film on the hair surface, and endow the pet hair with luster and softness, and is antistatic and easy to comb.

Preferably, the conditioning agent is methyl silicone oil, also known as dimethicone.

In one embodiment, the transdermal agent may be selected from at least one of isopropyl myristate, dimethyl sulfoxide, decyl methyl sulfoxide, and laurocapram. It will be appreciated that the addition of the transdermal agent described above may promote faster and greater penetration of the antimicrobial component into the skin or into the circulatory system, thereby more effectively exerting local or systemic antimicrobial, therapeutic effects.

Preferably, the transdermal agent is dimethyl sulfoxide and/or isopropyl myristate. Dimethyl sulfoxide can not only play a role of a transdermal agent in the embodiment of the application, but also can be used as a cosolvent to improve the compatibility of each component in the system.

In one embodiment, the preservative is methylisothiazolinone and/or methylchloroisothiazolinone. The methylisothiazolinone and the methylchloroisothiazolinone belong to the hot water-resistant preservatives, have good effects of inhibiting the growth and the reproduction of microorganisms, can inhibit the growth and the reproduction of bacteria, fungi and mold, can improve the stability of products on one hand, and can increase the antibacterial and bacteriostatic properties of the products on the other hand.

In one embodiment, the pH adjuster may be an organic acid such as citric acid, malic acid, or benzoic acid, or an inorganic acid such as hydrochloric acid. Preferably, citric acid is used.

In one embodiment, the diluent may be selected from water, ethanol, propylene glycol, isopropanol, and dimethylformamide.

Preferably, the diluent is water. Thus, the stimulation of the detergent to pets can be reduced, and the production cost can be reduced.

In one embodiment, the detergent further comprises 0.1-2 wt% of a thickening agent and/or 0.01-2 wt% of essence.

It is understood that the addition of a suitable amount of thickener may improve the viscosity and stability of the wash; and the addition of a proper amount of essence can make the detergent have better smell so as to improve the sensory performance of the product.

In one embodiment, the thickener is at least one selected from sodium chloride, magnesium chloride, potassium chloride, sodium dihydrogen phosphate, potassium dihydrogen phosphate, sodium benzoate, etc. Preferably, the thickener is sodium chloride.

In one embodiment, the essence can be natural plant essence or synthetic essence

Preferably, natural plant essences such as grapefruit essence, rose essence, lily essence, violet essence, etc. are used.

In one embodiment, the detergent comprises the following raw material components in percentage by weight: 1 to 3 percent of miconazole nitrate, 1 to 3 percent of chlorhexidine gluconate, 0.5 to 2 percent of thymol, 0.01 to 0.05 percent of dibutyl hydroxy toluene, 6 to 15 percent of cocamidopropyl betaine, 3 to 8 percent of coconut fatty acid diethanolamide, 2 to 6 percent of dimethyl sulfoxide, 2 to 6 percent of isopropyl myristate, 0.001 to 0.01 percent of methyl isothiazolinone, 1 to 4 percent of methyl silicone oil, 0.5 to 2 percent of citric acid, 0.1 to 0.5 percent of thickening agent, 0.1 to 0.5 percent of essence and the balance of water.

the components are uniformly mixed according to the formula of the detergent.

Specifically, miconazole nitrate, a transdermal agent, a part of surfactant and chlorhexidine gluconate are sequentially mixed, and then the rest surfactant, thymol, a preservative, an antioxidant, a conditioner, a thickening agent, a pH regulator, essence and water are added into a container and uniformly mixed to obtain the antibacterial detergent. It should be noted that the adding process requires continuous stirring, and the next component is added after the former component is completely dissolved, so as to mix the components thoroughly.

The following are specific examples

The raw materials used in the embodiment of the application are all common commercial products, wherein the chlorhexidine gluconate is 20% of chlorhexidine gluconate aqueous solution.

Example 1

An antibacterial detergent comprises the following components in percentage by weight: 2% miconazole nitrate, 2% chlorhexidine gluconate, 1% thymol, 5% dimethyl sulfoxide, 0.02% dibutylhydroxytoluene, 5% isopropyl myristate, 10% cocamidopropyl betaine, 5% coconut oil fatty acid diethanolamide, 0.005% methylisothiazolinone, 2% polydimethylsiloxane, 2% citric acid, 0.1% grapefruit essence and 66.875% purified water.

The preparation method comprises the following steps:

sequentially adding miconazole nitrate, dimethyl sulfoxide, thymol, cocamidopropyl betaine, isopropyl myristate, chlorhexidine gluconate, coconut oil fatty acid diethanolamide, methylisothiazolinone, dibutyl hydroxy toluene, polydimethylsiloxane, citric acid, grapefruit essence and purified water into a preparation container, stirring while adding, adding the next component after the former component is completely dissolved, and stirring uniformly.

Example 2

An antibacterial detergent comprises the following components in percentage by weight: 2% miconazole nitrate, 2% chlorhexidine gluconate, 1% thymol, 5% dimethyl sulfoxide, 0.02% dibutyl hydroxy toluene, 5% isopropyl myristate, 10% cocamidopropyl betaine, 10% sodium fatty alcohol polyoxyethylene ether sulfate, 0.005% methyl isothiazolinone, 2% polydimethylsiloxane, 2% citric acid, 0.1% grapefruit essence and the balance of purified water.

The preparation method comprises the following steps:

sequentially adding miconazole nitrate, dimethyl sulfoxide, thymol, cocamidopropyl betaine, isopropyl myristate, chlorhexidine gluconate, fatty alcohol-polyoxyethylene ether sodium sulfate, methylisothiazolinone, dibutyl hydroxy toluene, polydimethylsiloxane, citric acid, grapefruit essence and purified water into a preparation container, stirring while adding, adding the next component after the former component is completely dissolved, and stirring uniformly.

Example 3

An antibacterial detergent comprises the following components in percentage by weight: 5% miconazole nitrate, 2% chlorhexidine gluconate, 1% thymol, 5% dimethyl sulfoxide, 0.02% dibutyl hydroxy toluene, 5% isopropyl myristate, 10% cocamidopropyl betaine, 10% coconut oil fatty acid diethanol amide, 0.005% methyl isothiazolinone, 2% polydimethylsiloxane, 2% citric acid, 0.1% grapefruit essence and the balance of purified water.

The preparation method comprises the following steps:

Example 4

An antibacterial detergent comprises the following components in percentage by weight: 2% miconazole nitrate, 2% chlorhexidine gluconate, 1% thymol, 5% dimethyl sulfoxide, 0.02% dibutyl hydroxy toluene, 5% isopropyl myristate, 20% polyquaternium-7, 5% coconut oil fatty acid diethanolamide, 0.005% methyl isothiazolinone, 2% polydimethylsiloxane, 2% citric acid, 0.1% grapefruit essence and 66.875% purified water.

The preparation method comprises the following steps:

sequentially adding miconazole nitrate, dimethyl sulfoxide, thymol, polyquaternium-7, isopropyl myristate, chlorhexidine gluconate, coconut oil fatty acid diethanolamide, methylisothiazolinone, dibutyl hydroxy toluene, polydimethylsiloxane, citric acid, grapefruit essence and purified water into a preparation container, stirring while adding, adding the next component after the former component is completely dissolved, and stirring uniformly.

Example 5

An antibacterial detergent comprises the following components in percentage by weight: 1% miconazole nitrate, 1% chlorhexidine gluconate, 0.5% thymol, 5% dimethyl sulfoxide, 0.02% dibutyl hydroxy toluene, 5% isopropyl myristate, 10% cocamidopropyl betaine, 5% coconut oil fatty acid diethanol amide, 0.005% methyl isothiazolinone, 2% polydimethylsiloxane, 2% citric acid, 0.1% grapefruit essence and 66.875% purified water.

The preparation method comprises the following steps:

Comparative example 1

An antibacterial detergent comprises the following components in percentage by weight: 2% miconazole nitrate, 2% chlorhexidine gluconate, 5% dimethyl sulfoxide, 0.02% dibutylhydroxytoluene, 5% isopropyl myristate, 10% cocamidopropyl betaine, 5% coconut oil fatty acid diethanolamide, 0.005% methylisothiazolinone, 2% polydimethylsiloxane, 2% citric acid, 0.1% grapefruit essence and 66.875% purified water.

The preparation method comprises the following steps:

sequentially adding miconazole nitrate, dimethyl sulfoxide, cocamidopropyl betaine, isopropyl myristate, chlorhexidine gluconate, coconut oil fatty acid diethanolamide, methylisothiazolinone, dibutyl hydroxy toluene, polydimethylsiloxane, citric acid, grapefruit essence and purified water into a preparation container, stirring while adding, adding the next component after the former component is completely dissolved, and stirring uniformly.

Comparative example 2

Comparative example 2 is substantially the same as example 1 except that no chlorhexidine gluconate is present in comparative example 2.

Proof of Effect test

The samples obtained in examples 1-5 and comparative examples 1-2 are subjected to an effect proof test, and specifically have antibacterial test and clinical use effects.

First, bacteriostasis test

Preparation of staphylococcus aureus bacterial suspension: inoculating the strain in BP culture medium (10 g of peptone, 1.5g of potassium dihydrogen phosphate, 9g of disodium hydrogen phosphate, 5g of sodium chloride and 1000mL of distilled water), culturing at 37 ℃ for 16-20 h, selecting single colony, inoculating in 10mL MH broth tube, performing shaking culture at 37 ℃ for 4-8 h, diluting the bacterial solution with MH broth to make the diluted bacterial solution reach the turbidity of 0.5 McLeod turbiditube (1.5 × 10)⁸CFU/mL). Then diluting the bacterial liquid according to the ratio of 1:100 until the bacterial content is about 1 multiplied by 10⁶CFU/mL, spare. The bacterial suspension should be stored in a refrigerator at 4 ℃ for future use. Should be used on the same day, not overnight.

Preparing a culture medium containing an antibacterial detergent: the antibacterial detergents of examples 1-5 and comparative examples 1-2 were selected, diluted with sterile water at a ratio of 1:10, and then filtered through a 0.45um filter membrane. Separately packaging sterilized MH broth 5mL in each test tube, adding diluted antibacterial detergent (1:10)5mL in the first test tube, mixing, transferring 5mL into the second tube, mixing the third, fourth, fifth and sixth tubes by the same method, mixing the sixth tube, transferring 5mL, and making liquid medicine control in the seventh tube. The bacteria solution was inoculated into a test tube of nutrient broth without antimicrobial detergent as a positive control. Test tubes containing nutrient broth alone served as a negative control.

Placing the culture medium in an incubator at 37 ℃, culturing for 16-20 h, and observing a primary result.

And (3) judging test results: the turbidity of the tubes with bacteria was designated "+" and the clarity of the tubes with bacteria was designated "-", and the results are shown in Table 1 below.

TABLE 1 results of the bacteriostatic test

Test results show that the antibacterial detergent in the examples 1-5 has an inhibitory effect on staphylococcus aureus in vitro at a certain concentration, and shows a good antibacterial effect; the detergents of comparative examples 1 and 2 had bacteria growing when diluted 40 times or more, indicating that the bacteriostatic effect was not good.

Second, investigation of clinical effects

The experimental site: the results of the use of the antimicrobial detergent of example 1 in a Canine farm in Guangzhou were examined for 30 pet dogs and are shown in Table 2 below.

TABLE 2 investigation results of clinical effects

Note: -represents none; + means light; + represents medium; , + + + + represents severe; and + + + + represents very severe.

From the above test results, the antibacterial detergent of embodiment 1 has good decontamination and bacteriostasis effects, and can maintain normal physiological environment of hair and skin, and has low allergy, no irritation, and no side effects.

Third, concrete treatment cases

In 2017, from 4 months to 10 months, 30 dogs with fungal skin diseases and non-systemic clinical manifestations are diagnosed in a certain animal clinic in Guangzhou region.

The premise is that the owner of the sick dog agrees to match with follow-up investigation. Washing with the antibacterial detergent of example 1 every week for 30 days; hypoallergenic food feeding is used to avoid possible food allergies. The therapeutic effect of the examined affected dogs was evaluated at 10d, 20d, and 30d from the start of treatment. An appointment with the owner of the sick dog is made, and the owner is invited to bring the sick dog to a pet clinic for examination. The treatment effect is divided into recovery, obvious effect, improvement and no effect. The evaluation criteria are shown in Table 3 below.

TABLE 3

The effective case number is the number of cure cases plus the number of obvious cases.

Skin samples were collected from the affected part of the affected dog at 10d, 20d, and 30d after the start of treatment. The collection method comprises the steps of gently scraping the skin scraps of the affected part by using a surgical blade, collecting the skin scraps into a clean EP tube, bringing the tube back to a laboratory for culture identification, and if the culture result of pathogenic bacteria is negative, judging that the tube turns negative, wherein the test result is shown in the following table 4.

TABLE 4

Time of day	Rate of recovery	High efficiency	Negative conversion rate
				10 days	73％	86.5％	61％
20 days	86.8％	100％	72％
				30 days	100％	100％	87.4％

Test results show that the pet antibacterial detergent of the embodiment 1 has a remarkable treatment effect on fungal dermatosis.

The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.

The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims

1. The antibacterial detergent is characterized by comprising the following raw material components in percentage by weight: 0.1-20% of miconazole nitrate, 0.1-20% of chlorhexidine gluconate, 0.1-5% of thymol, 0.005-5% of antioxidant, 1-50% of surfactant, 0.001-0.01% of preservative, 1-10% of conditioner, 1-50% of transdermal agent, 0-5% of pH regulator and 45-90% of diluent.

2. The antibacterial detergent according to claim 1, characterized in that the antibacterial detergent comprises the following raw material components in percentage by weight: 0.1-5% of miconazole nitrate, 0.1-5% of chlorhexidine gluconate, 0.1-2% of thymol, 0.005-0.5% of antioxidant, 1-30% of surfactant, 0.001-0.01% of preservative, 1-5% of conditioner, 1-15% of transdermal agent, 0.1-3% of pH regulator and 45-90% of diluent.

3. The antimicrobial detergent of claim 1, wherein said surfactant is selected from at least one of coconut diethanolamide, polyquaternium-7, sodium fatty alcohol polyoxyethylene ether sulfate, and cocamidopropyl betaine.

4. The antibacterial detergent according to claim 3, wherein the surfactant is a combination of coco fatty acid diethanolamide and cocamidopropyl betaine, and the weight ratio of coco fatty acid diethanolamide to cocamidopropyl betaine is (1-2): 1.

5. The antiseptic detergent of claim 1 wherein said antioxidant is selected from at least one of tocopherol, butylated hydroxyanisole, butylated hydroxytoluene, and tertiary butyl hydroquinone.

6. The antibacterial detergent according to claim 1, wherein said conditioning agent is at least one selected from the group consisting of methyl silicone oil, ethyl silicone oil, phenyl silicone oil, methyl hydrogen-containing silicone oil, methylphenyl silicone oil, methyl chlorophenyl silicone oil, methyl ethoxy silicone oil, methyl trifluoropropyl silicone oil, methyl hydroxy silicone oil, ethyl hydrogen-containing silicone oil, hydroxy hydrogen-containing silicone oil and cyanogen-containing silicone oil.

7. The antibacterial detergent according to claim 1, wherein the transdermal agent is selected from at least one of isopropyl myristate, dimethyl sulfoxide, decyl methyl sulfoxide, and laurocapram.

8. The antibacterial detergent according to claim 1, characterized in that the antibacterial detergent further comprises 0.1-2% of a thickening agent and/or 0.01-2% of essence by weight percentage.

9. The antibacterial detergent according to any one of claims 1 to 8, which comprises the following raw material components in percentage by weight: 1 to 3 percent of miconazole nitrate, 1 to 3 percent of chlorhexidine gluconate, 0.5 to 2 percent of thymol, 0.01 to 0.05 percent of dibutyl hydroxy toluene, 6 to 15 percent of cocamidopropyl betaine, 3 to 8 percent of coconut fatty acid diethanolamide, 2 to 6 percent of dimethyl sulfoxide, 2 to 6 percent of isopropyl myristate, 0.001 to 0.01 percent of methyl isothiazolinone, 1 to 4 percent of methyl silicone oil, 0.5 to 2 percent of citric acid, 0.1 to 0.5 percent of thickening agent, 0.1 to 0.5 percent of essence and the balance of water.

10. A method of preparing an antibacterial detergent according to any one of claims 1 to 9, comprising the steps of:

and (3) uniformly mixing the components according to the formula of the antibacterial detergent.