CN110584796A - Tissue marking needle - Google Patents

Abstract

An embodiment of the present invention provides a tissue marking needle, which comprises a base and a hook body, wherein the base is provided with a luminescent coating, the hook body is arranged outside the base, and connects the base to the tissue to be marked. When in use, the tissue marking needle can be conveniently placed on the tissue to be marked through the biopsy channel of the colonoscope, which reduces the difficulty of the operation for the surgeon and reduces the pain of the patient.

Description

Tissue marker needle

technical field

The invention belongs to the technical field of tissue marking, and in particular relates to a tissue marking needle.

Background technique

With the increasing popularity of screening angiography programs, most tumors are detected as small, nonpalpable, or shallowly occult lesions. Accurate localization of such tumors is critical to allow surgical removal of the entire tumor with adequate margins. If not all of the tumor is removed, the patient will need to undergo additional surgery to remove any remaining cancerous tissue. Accurate positioning also helps avoid resection of excess normal tissue.

Nonpalpable lesions or abnormalities can be detected by routine or screening angiography. If the abnormality is not palpable, during diagnosis, a tissue biopsy is usually performed using a vacuum-assisted biopsy (VAB) needle or a core biopsy needle. After the biopsy, initial tissue markers are placed so that the site can be located during subsequent procedures. After the biopsy sample is analyzed, if the sample is benign, the tissue markers are kept in the patient long-term; if the biopsy reveals a cancerous tumor, the patient is surgically removed to remove the tumor.

Existing methods of tissue labeling suffer from the following problems: possible introduction of radioactive materials, some radioisotopes have short half-lives, limiting the time between drug administration and surgery; two types of markers need to be placed at the surgical site, first Tissue markers are placed after the biopsy to mark the biopsy site. Additional marking tools such as radiotracers or radioactive particles need to be placed at the same site later. This repeated operation increases the work of the surgical team and the radiology team, and also increases pain and risk for the patient.

In summary, a new tissue marker is still needed.

Contents of the invention

In order to solve the problems existing in the tissue markers used in surgery in the prior art, the embodiment of the present invention provides a tissue marking needle, which includes a base and a hook body, wherein the base is provided with a light-emitting Coating, the hook body is set outside the base, and the base is connected with the tissue to be marked. When in use, the tissue marking needle can be conveniently placed on the tissue to be marked through the biopsy channel of the colonoscope, reducing the need for surgery. The operation difficulty of the doctor also reduces the pain of the patient.

One of the embodiments of the present invention adopts the following technical solutions:

Tissue marker needles, including

a base, the base is provided with a luminescent coating;

The hook body is arranged outside the base and fixedly connected with the base.

In the tissue marking needle of the embodiment of the present invention, the base is provided with a luminescent coating, which on the one hand plays the role of marking, and can accurately locate and mark the tissue part of the biopsy; on the other hand, it is also convenient to find the mark again. The hook body can penetrate into the tissue and is used to fix the base on the tissue. When in use, the tissue marking needle can be conveniently placed on the tissue to be marked through the biopsy channel of the colonoscope, which reduces the difficulty of operation for the surgeon and reduces the pain of the patient.

Preferably, the material of the tissue marking needle is a degradable material.

The material of the tissue marking needle is a degradable material, so that the tissue marking needle can be completely degraded in the body, and there is no need to perform an operation again in order to take the tissue marking needle out of the body. It solves the problem in the prior art that the marker needs to be taken out through reoperation.

Further preferably, the degradable materials include polylactide (PLA), poly(lactide-co-glycolide) (PLGA), polyanhydrides, polyorthoesters, poly(N-(2-hydroxypropyl base) methacrylamide), poly(dl-lactide) (DLPLA), poly(l-lactide) (LPLA), polyglycolide (PGA), polydioxanone (PDO) , poly(glycolide-co-trimethylene carbonate) (PGA-TMC).

Still further preferably, the degradable material also includes poly(l-lactide-co-glycolide) (PGA-LPLA), poly(dl-lactide-co-glycolide) (PGA-DLPLA ), poly(l-lactide-co-dl-lactide) (LPLA-DLPLA), poly(glycolide-co-trimethylene carbonate-co-dioxanone) (PDO- One or more copolymers of PGA-TMC) and polyarginine.

The above-mentioned degradable materials can be degraded in the body, and are safe and non-toxic.

Preferably, the shape of the base (10) is a cylinder, and the hook is fixedly arranged on the side of the cylinder.

The hook body is fixedly arranged on the side of the cylinder, which is convenient for fixing the tissue marking needle to the tissue to be marked.

Preferably, the upper bottom surface and/or the lower bottom surface of the cylinder is bullet-shaped.

The bullet-shaped design facilitates the advancement of the tissue marking needle in the biopsy channel of the colonoscope.

Preferably, the luminescent coating is a poly((bis(p-carboxyphenyl)succinate-comonosebacic anhydride) (P(p-dCPS:SA)) coating.

The above-mentioned luminescent coating can control the degradation rate of the coating between several days to several months by adjusting different salicylic acid (SA) ratios.

The above luminescent coating can emit blue fluorescence when excited by ultraviolet light (330-400nm), and emit green fluorescence when excited by visible light (450-490nm).

The luminescent coating enables the tissue marking pins to be quickly identified.

Preferably, the number of said hook bodies is at least 3.

When the number of hook bodies is 3, the 3 hook bodies are evenly distributed outside the base, so that the tissue marking needle has a tripod-shaped structure as a whole, and the base can be firmly fixed on the tissue.

Further preferably, the hook body includes a first hook body (110), a second hook body (120) and a third hook body (130).

Further preferably, the first hook body (110) is provided with a first barb (1110), the second hook body (120) is provided with a second barb (1210), and the third hook A third barb (1310) is disposed on the body (130).

The setting of the barb further strengthens the stability that the tissue marking needle is fixed on the tissue.

Preferably, the hook body material is water-swellable material.

Further preferably, the hook body material is gelatin.

Gelatin will swell when exposed to water or interstitial fluid, and the enlarged hook body will make the connection between the base and the tissue more firm.

Preferably, the hook body includes a straight hook and a curved hook.

The hook body is a straight hook, which is convenient for advancing and releasing the tissue marking needle.

The hook body is a curved hook, which facilitates a more stable connection between the base and the tissue.

Beneficial effects of the embodiments of the present invention

1. The embodiment of the present invention provides a tissue marking needle. The tissue marking needle includes a base and a hook body, wherein the base is provided with a luminous coating, and the hook body is arranged outside the base. The tissue is connected, and when in use, the tissue marking needle can be conveniently placed on the tissue to be marked through the biopsy channel of the colonoscope, which reduces the difficulty of the operation of the surgeon and the pain of the patient;

2. The material of the tissue marking needle in the embodiment of the present invention is a degradable material, so that the tissue marking needle can be completely degraded in the body, and there is no need to perform surgery again in order to take the tissue marking needle out of the body, which solves the problem in the prior art. Reoperation to remove the markers;

3. In the tissue marking needle of the embodiment of the present invention, the surface of the base is provided with a luminescent coating, and the luminescent coating is poly((bis(p-carboxyphenyl)succinate-co-sebacic anhydride)(P (p-dCPS: SA)) coating, the degradation rate of the coating can be controlled between a few days and a few months by adjusting different salicylic acid (SA) ratios, and excited by ultraviolet light (330-400nm) It can emit blue fluorescence under the excitation of visible light (450-490nm), and can emit green fluorescence, so that the tissue marker needle can be quickly identified and found, which solves the problem in the prior art. Additional marking tools such as radiotracers or radioactive particles need to be placed at the same site, and repeated operations add to the problems of the surgical and radiological teams.

Description of drawings

Fig. 1 is a schematic diagram of the tissue marking needle in embodiment 1.

Fig. 2 is a schematic diagram of the tissue marking needle in embodiment 2.

Detailed ways

The following are specific examples of the present invention, and further describe the technical solutions of the present invention in conjunction with the examples, but the present invention is not limited to these examples.

Example 1

This example provides a tissue marking needle, as shown in Figure 1, the tissue marking needle includes

A base 10, the base 10 is provided with a luminous coating;

The hook body, the hook body is arranged outside the base 10 and fixedly connected with the base 10 .

In the tissue marking needle of the embodiment of the present invention, the base is provided with a luminescent coating, which on the one hand plays the role of marking, and can accurately locate and mark the tissue part of the biopsy; on the other hand, it is also convenient to find the mark again. The hook body can penetrate into the tissue and is used to fix the base on the tissue. When in use, the tissue marking needle can be conveniently placed on the tissue to be marked through the biopsy channel of the colonoscope, which reduces the difficulty of operation for the surgeon and reduces the pain of the patient.

The material of the tissue marking needle is a degradable material, so that the tissue marking needle can be completely degraded in the body, and there is no need to perform an operation again in order to take the tissue marking needle out of the body. It solves the problem in the prior art that the marker needs to be taken out through reoperation. Degradable materials include polylactide (PLA), poly(lactide-co-glycolide) (PLGA), polyanhydrides, polyorthoesters, poly(N-(2-hydroxypropyl)methacrylamide ), poly(dl-lactide) (DLPLA), poly(l-lactide) (LPLA), polyglycolide (PGA), polydioxanone (PDO), poly(glycolide -co-trimethylene carbonate) (PGA-TMC). Degradable materials also include poly(l-lactide-co-glycolide) (PGA-LPLA), poly(dl-lactide-co-glycolide) (PGA-DLPLA), poly(l-lactide-co-glycolide) Lactide-co-dl-lactide) (LPLA-DLPLA), poly(glycolide-co-trimethylene carbonate-co-dioxanone) (PDO-PGA-TMC) and polyfine One or several copolymers of amino acids.

The shape of the base 10 is a cylinder, and the hook is fixedly arranged on the side of the cylinder.

The upper bottom surface and/or the lower bottom surface of the cylinder is bullet-shaped.

The luminescent coating is a poly((bis(p-carboxyphenyl)succinate-co-sebacic anhydride) (P(p-dCPS:SA)) coating.

The number of hook body is at least 3. When the number of hook bodies is 3, the 3 hook bodies are evenly distributed outside the base, so that the tissue marking needle has a tripod-shaped structure as a whole, and the base can be firmly fixed on the tissue.

The hook body includes a first hook body 110 , a second hook body 120 and a third hook body 130 .

The first hook body 110 is provided with a first barb 1110 , the second hook body 120 is provided with a second barb 1210 , and the third hook body 130 is provided with a third barb 1310 . The setting of the barb further strengthens the stability that the tissue marking needle is fixed on the tissue. The material of the hook body is gelatin, and the gelatin will swell when exposed to water or interstitial fluid. After the hook body becomes larger, the connection between the base and the tissue becomes stronger.

In this example, the hook body is a straight hook.

Example 2

This example provides a tissue marking needle, as shown in Figure 1, the tissue marking needle includes

A base 10, the base 10 is provided with a luminescent coating;

The hook body, the hook body is arranged outside the base 10 and fixedly connected with the base 10 .

In the tissue marking needle of the embodiment of the present invention, the base is provided with a luminescent coating, which on the one hand plays the role of marking, and can accurately locate and mark the tissue part of the biopsy; on the other hand, it is also convenient to find the mark again. The hook body can penetrate into the tissue and is used to fix the base on the tissue. When in use, the tissue marking needle can be conveniently placed on the tissue to be marked through the biopsy channel of the colonoscope, which reduces the difficulty of operation for the surgeon and reduces the pain of the patient.

The material of the tissue marking needle is a degradable material, so that the tissue marking needle can be completely degraded in the body, and there is no need to perform an operation again in order to take the tissue marking needle out of the body. It solves the problem in the prior art that the marker needs to be taken out through reoperation. Degradable materials include polylactide (PLA), poly(lactide-co-glycolide) (PLGA), polyanhydrides, polyorthoesters, poly(N-(2-hydroxypropyl)methacrylamide ), poly(dl-lactide) (DLPLA), poly(l-lactide) (LPLA), polyglycolide (PGA), polydioxanone (PDO), poly(glycolide -co-trimethylene carbonate) (PGA-TMC). Degradable materials also include poly(l-lactide-co-glycolide) (PGA-LPLA), poly(dl-lactide-co-glycolide) (PGA-DLPLA), poly(l-lactide-co-glycolide) Lactide-co-dl-lactide) (LPLA-DLPLA), poly(glycolide-co-trimethylene carbonate-co-dioxanone) (PDO-PGA-TMC) and polyfine One or several copolymers of amino acids.

The shape of the base 10 is a cylinder, and the hook is fixedly arranged on the side of the cylinder.

The upper bottom surface and/or the lower bottom surface of the cylinder is bullet-shaped.

The luminescent coating is a poly((bis(p-carboxyphenyl)succinate-co-sebacic anhydride) (P(p-dCPS:SA)) coating.

The number of hook body is at least 3. When the number of hook bodies is 3, the 3 hook bodies are evenly distributed outside the base, so that the tissue marking needle has a tripod-shaped structure as a whole, and the base can be firmly fixed on the tissue.

The hook body includes a first hook body 110 , a second hook body 120 and a third hook body 130 .

The first hook body 110 is provided with a first barb 1110 , the second hook body 120 is provided with a second barb 1210 , and the third hook body 130 is provided with a third barb 1310 . The setting of the barb further strengthens the stability that the tissue marking needle is fixed on the tissue. The material of the hook body is gelatin, and the gelatin will swell when exposed to water or interstitial fluid. After the hook body becomes larger, the connection between the base and the tissue becomes stronger.

In this example, the hook body is a crotch.

Example 3

This example provides the usage method of the tissue marking needle, specifically:

During use, the tissue marking needle is applied to the tissue site to be marked through the biopsy channel of the colonoscope.

The biopsy channel of the colonoscope is a common channel for operations such as biopsy tissue collection, drug injection, and electrical resection of polyps. Through this channel, the tissue marking needle can be conveniently placed on the tissue site that needs to be marked. The upper bottom surface of the tissue marking needle base, that is, the side connected to the biopsy channel of the colonoscope, can be directly designed to a size suitable for the biopsy hole, so as to facilitate the application of the tissue marking needle directly through the biopsy channel. In addition, an additional connector can also be designed, and the function of the connector is to connect the base on which the tissue marker is placed and the biopsy channel of the colonoscope, so as to facilitate the deployment of the tissue marker needle.

Claims (10)

1. A tissue marking needle, comprising

A base (10), wherein a luminous coating is arranged on the base (10);

the hook body is arranged outside the base (10) and fixedly connected with the base (10).

2. The tissue marking needle of claim 1, wherein the material of the tissue marking needle is a degradable material.

3. The tissue marking needle of claim 2, wherein the degradable material comprises Polylactide (PLA), poly (lactide-co-glycolide) (PLGA), polyanhydrides, polyorthoesters, poly (N- (2-hydroxypropyl) methacrylamide), poly (dl-lactide) (DLPLA), poly (l-lactide) (LPLA), Polyglycolide (PGA), Polydioxanone (PDO), poly (glycolide-co-trimethylene carbonate) (PGA-TMC).

4. The tissue marking needle of claim 3 wherein the degradable material further comprises a copolymer of one or more of poly (l-lactide-co-glycolide) (PGA-LPLA), poly (dl-lactide-co-glycolide) (PGA-DLPLA), poly (l-lactide-co-dl-lactide) (LPLA-DLPLA), poly (glycolide-co-trimethylene carbonate-co-dioxanone) (PDO-PGA-TMC) and polyarginine.

5. The tissue marking needle according to claim 1, characterized in that the base (10) is shaped as a cylinder, the hook being fixedly arranged on a side of the cylinder.

6. The tissue marking needle of claim 5 wherein the upper and/or lower bottom surface of the cylinder is bullet-shaped.

7. The tissue marking needle of claim 1 wherein the luminescent coating is a poly ((P-bis (P-carboxyphenyl) succinate-co-sebacic anhydride) (P (P-dCPS: SA)) coating.

8. The tissue marking needle according to claim 1, wherein the number of hooks is at least 3, the hooks comprising a first hook (110), a second hook (120) and a third hook (130).

9. The tissue marking needle of claim 8, wherein the first hook body (110) is provided with a first barb (1110), the second hook body (120) is provided with a second barb (1210), and the third hook body (130) is provided with a third barb (1310).

10. The tissue marking needle of claim 1, wherein the hook body comprises a straight hook and a curved hook.