CN110583648A - Composite quaternary ammonium salt disinfectant and its preparation method - Google Patents
Composite quaternary ammonium salt disinfectant and its preparation method Download PDFInfo
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- CN110583648A CN110583648A CN201910792423.4A CN201910792423A CN110583648A CN 110583648 A CN110583648 A CN 110583648A CN 201910792423 A CN201910792423 A CN 201910792423A CN 110583648 A CN110583648 A CN 110583648A
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- quaternary ammonium
- ammonium salt
- disinfectant
- chloride
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 88
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 239000002131 composite material Substances 0.000 title claims description 31
- 150000003242 quaternary ammonium salts Chemical class 0.000 title description 13
- -1 compound quaternary ammonium salt Chemical class 0.000 claims abstract description 67
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 54
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims abstract description 42
- 239000001230 potassium iodate Substances 0.000 claims abstract description 36
- 229940093930 potassium iodate Drugs 0.000 claims abstract description 36
- 235000006666 potassium iodate Nutrition 0.000 claims abstract description 36
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims abstract description 28
- 229920002498 Beta-glucan Polymers 0.000 claims abstract description 28
- JMHWNJGXUIJPKG-UHFFFAOYSA-N CC(=O)O[SiH](CC=C)OC(C)=O Chemical compound CC(=O)O[SiH](CC=C)OC(C)=O JMHWNJGXUIJPKG-UHFFFAOYSA-N 0.000 claims abstract description 28
- 239000005714 Chitosan hydrochloride Substances 0.000 claims abstract description 28
- JBIROUFYLSSYDX-UHFFFAOYSA-M benzododecinium chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 JBIROUFYLSSYDX-UHFFFAOYSA-M 0.000 claims abstract description 28
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 claims abstract description 28
- FABPRXSRWADJSP-MEDUHNTESA-N moxifloxacin Chemical compound COC1=C(N2C[C@H]3NCCC[C@H]3C2)C(F)=CC(C(C(C(O)=O)=C2)=O)=C1N2C1CC1 FABPRXSRWADJSP-MEDUHNTESA-N 0.000 claims abstract description 28
- 229960003702 moxifloxacin Drugs 0.000 claims abstract description 28
- 229920000098 polyolefin Polymers 0.000 claims abstract description 28
- MENYRYNFSIBDQN-UHFFFAOYSA-N 5,5-dibromoimidazolidine-2,4-dione Chemical compound BrC1(Br)NC(=O)NC1=O MENYRYNFSIBDQN-UHFFFAOYSA-N 0.000 claims abstract description 27
- 229960000583 acetic acid Drugs 0.000 claims abstract description 27
- 239000012362 glacial acetic acid Substances 0.000 claims abstract description 27
- 229940048848 lauryl glucoside Drugs 0.000 claims abstract description 27
- PYIDGJJWBIBVIA-UYTYNIKBSA-N lauryl glucoside Chemical compound CCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O PYIDGJJWBIBVIA-UYTYNIKBSA-N 0.000 claims abstract description 27
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims abstract description 21
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims abstract description 21
- 239000004094 surface-active agent Substances 0.000 claims abstract description 21
- 229960004198 guanidine Drugs 0.000 claims abstract description 17
- 239000002994 raw material Substances 0.000 claims abstract description 15
- JLKDVMWYMMLWTI-UHFFFAOYSA-M potassium iodate Chemical compound [K+].[O-]I(=O)=O JLKDVMWYMMLWTI-UHFFFAOYSA-M 0.000 claims description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 26
- JDLKFOPOAOFWQN-VIFPVBQESA-N Allicin Natural products C=CCS[S@](=O)CC=C JDLKFOPOAOFWQN-VIFPVBQESA-N 0.000 claims description 25
- JDLKFOPOAOFWQN-UHFFFAOYSA-N allicin Chemical compound C=CCSS(=O)CC=C JDLKFOPOAOFWQN-UHFFFAOYSA-N 0.000 claims description 25
- 235000010081 allicin Nutrition 0.000 claims description 25
- 239000011259 mixed solution Substances 0.000 claims description 24
- 239000012528 membrane Substances 0.000 claims description 17
- 239000012153 distilled water Substances 0.000 claims description 16
- 238000003756 stirring Methods 0.000 claims description 16
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 15
- 239000011630 iodine Substances 0.000 claims description 15
- 229960002358 iodine Drugs 0.000 claims description 15
- 229910052740 iodine Inorganic materials 0.000 claims description 15
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 14
- 238000001728 nano-filtration Methods 0.000 claims description 14
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 claims description 9
- 229920000153 Povidone-iodine Polymers 0.000 claims description 9
- 229960001621 povidone-iodine Drugs 0.000 claims description 9
- 239000002033 PVDF binder Substances 0.000 claims description 8
- 229920002981 polyvinylidene fluoride Polymers 0.000 claims description 8
- 229920002413 Polyhexanide Polymers 0.000 claims description 7
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 7
- 239000004800 polyvinyl chloride Substances 0.000 claims description 7
- 239000002202 Polyethylene glycol Substances 0.000 claims description 5
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 claims description 5
- 229940070765 laurate Drugs 0.000 claims description 5
- 229920001223 polyethylene glycol Polymers 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 3
- 125000000373 fatty alcohol group Chemical group 0.000 claims description 3
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 3
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 3
- 238000000108 ultra-filtration Methods 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 24
- 230000000694 effects Effects 0.000 abstract description 13
- 241000222122 Candida albicans Species 0.000 abstract description 6
- 241000588724 Escherichia coli Species 0.000 abstract description 6
- 241000191967 Staphylococcus aureus Species 0.000 abstract description 6
- 229940095731 candida albicans Drugs 0.000 abstract description 6
- 230000000249 desinfective effect Effects 0.000 abstract description 6
- 230000006378 damage Effects 0.000 abstract description 5
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 abstract description 4
- 229910052751 metal Inorganic materials 0.000 abstract description 3
- 239000002184 metal Substances 0.000 abstract description 3
- 235000013675 iodine Nutrition 0.000 description 13
- 230000001954 sterilising effect Effects 0.000 description 11
- 230000007797 corrosion Effects 0.000 description 7
- 238000005260 corrosion Methods 0.000 description 7
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 5
- 229910052782 aluminium Inorganic materials 0.000 description 5
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 5
- 229910052802 copper Inorganic materials 0.000 description 5
- 239000010949 copper Substances 0.000 description 5
- 229910001220 stainless steel Inorganic materials 0.000 description 5
- 239000010935 stainless steel Substances 0.000 description 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 4
- 229960000789 guanidine hydrochloride Drugs 0.000 description 4
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 150000002191 fatty alcohols Chemical class 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- ZKQDCIXGCQPQNV-UHFFFAOYSA-N Calcium hypochlorite Chemical compound [Ca+2].Cl[O-].Cl[O-] ZKQDCIXGCQPQNV-UHFFFAOYSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- FTSSQIKWUOOEGC-RULYVFMPSA-N fructooligosaccharide Chemical compound OC[C@H]1O[C@@](CO)(OC[C@@]2(OC[C@@]3(OC[C@@]4(OC[C@@]5(OC[C@@]6(OC[C@@]7(OC[C@@]8(OC[C@@]9(OC[C@@]%10(OC[C@@]%11(O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%12O)O[C@H](CO)[C@@H](O)[C@@H]%11O)O[C@H](CO)[C@@H](O)[C@@H]%10O)O[C@H](CO)[C@@H](O)[C@@H]9O)O[C@H](CO)[C@@H](O)[C@@H]8O)O[C@H](CO)[C@@H](O)[C@@H]7O)O[C@H](CO)[C@@H](O)[C@@H]6O)O[C@H](CO)[C@@H](O)[C@@H]5O)O[C@H](CO)[C@@H](O)[C@@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H]1O FTSSQIKWUOOEGC-RULYVFMPSA-N 0.000 description 1
- 229940107187 fructooligosaccharide Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
- A01N25/10—Macromolecular compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N41/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
- A01N41/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/12—Iodine, e.g. iodophors; Compounds thereof
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Inorganic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention provides a compound quaternary ammonium salt disinfectant and a preparation method thereof, the compound quaternary ammonium salt disinfectant is prepared by taking dioctyldimethylammonium chloride, dodecyl dimethyl benzyl ammonium chloride, lauryl glucoside, glacial acetic acid, guanidine disinfectant, surfactant, compound potassium iodate, chitosan hydrochloride, dibromohydantoin, hydrogenated hyperbranched polyolefin, moxifloxacin, garlicin and beta-glucan palmitate as raw materials, can effectively inhibit and kill staphylococcus aureus, escherichia coli and candida albicans, can improve the killing efficiency of the compound quaternary ammonium salt disinfectant, and has high killing durability. In addition, the invention is used for disinfecting equipment, instruments, particularly medical instruments, the disinfection effect of the invention on the medical instruments can reach the disinfection effect of the glutaraldehyde disinfection product which is the mainstream product for disinfecting the medical instruments at present, and the invention does not damage the disinfected objects, has no pollution to the environment and does not corrode metal utensils and the like.
Description
Technical Field
The invention belongs to the field of disinfectants, and particularly relates to a compound quaternary ammonium salt disinfectant and a preparation method thereof.
Background
Medical instruments are concerned with the health of patients, and have higher requirements on disinfection and sterilization of the instruments. The existing medical instrument disinfectant is generally required to have the following characteristics: 1. the disinfectant has no corrosion to equipment and can be used for a long time; 2. the disinfection effect is good, and germs on the apparatus can be killed quickly; 3. the medicine is non-toxic and pollution-free, and does not cause physical damage to patients; 4. the disinfectant can not cause harm to operators.
At present, representative products for strong sterilization in the domestic disinfection product market mainly comprise the following products: 1. chlorine disinfectant: such as 84, bleaching powder and the like, the main effective components are organic chlorine, and the disinfectant has broad-spectrum and high-efficiency sterilization, strong irritation and strong corrosivity, is easily influenced by organic matters, pollutes the environment and can generate toxic and side effects on a human body. 2. A phenolic disinfectant: such as phenol, lesu, etc., has good sterilizing effect, strong irritation, heavy smell, is easily influenced by organic matters, has pollution to water and environment, and can generate toxic and side effects on human bodies. 3. Aldehyde disinfectant: such as glutaraldehyde, has good disinfection effect on medical instruments, but also has corrosion effect on the disinfected products. In the face of the urgent need of new environment-friendly and efficient disinfection products in various social fields, researchers develop various new products, wherein quaternary ammonium salt disinfectants are one of the disinfectants which are greatly expected. At present, quaternary ammonium salt disinfection products in the domestic disinfection product market are mostly single-component preparations or simple 'quaternary ammonium salt + quaternary ammonium salt' so-called compound products, and the sterilization effect is poor.
Disclosure of Invention
The invention provides a compound quaternary ammonium salt disinfectant and a preparation method thereof, which can effectively inhibit and kill staphylococcus aureus, escherichia coli and candida albicans, and can improve the killing efficiency of the compound quaternary ammonium salt disinfectant.
The technical scheme of the invention is realized as follows:
a compound quaternary ammonium salt disinfectant comprises the following raw materials in parts by weight:
20-30 parts of dioctyldimethylammonium chloride, 10-20 parts of dodecyldimethylbenzylammonium chloride, 2-4 parts of lauryl glucoside, 1-2 parts of glacial acetic acid, 3-5 parts of guanidine disinfectant, 20-40 parts of surfactant, 7-10 parts of potassium iodate, 3-5 parts of chitosan hydrochloride, 1-2 parts of dibromohydantoin, 1-2 parts of hydrogenated hyperbranched polyolefin, 1-2 parts of moxifloxacin, 2-3 parts of allicin, 1-2 parts of beta-glucan palmitate and 50-60 parts of distilled water.
Preferably, the feed comprises the following raw materials in parts by weight:
23-27 parts of dioctyldimethylammonium chloride, 15-20 parts of dodecyl dimethyl benzyl ammonium chloride, 2-3 parts of lauryl glucoside, 1-2 parts of glacial acetic acid, 3-4 parts of guanidine disinfectant, 25-35 parts of surfactant, 8-10 parts of potassium iodate complex, 4-5 parts of chitosan hydrochloride, 1.5-2 parts of dibromohydantoin, 1-1.5 parts of hydrogenated hyperbranched polyolefin, 1-2 parts of moxifloxacin, 2.5-3 parts of allicin, 1-1.5 parts of beta-glucan palmitate and 50-55 parts of distilled water.
Preferably, the feed comprises the following raw materials in parts by weight:
25 parts of dioctyldimethylammonium chloride, 15 parts of dodecyl dimethylbenzyl ammonium chloride, 3 parts of lauryl glucoside, 1 part of glacial acetic acid, 4 parts of guanidine disinfectant, 30 parts of surfactant, 8 parts of composite potassium iodate, 4 parts of chitosan hydrochloride, 2 parts of dibromohydantoin, 1 part of hydrogenated hyperbranched polyolefin, 2 parts of moxifloxacin, 3 parts of allicin, 1.5 parts of beta-glucan palmitate and 50 parts of distilled water.
Preferably, the guanidine disinfectant is polyhexamethylene biguanide hydrochloride, polyhexamethylene guanidine propionate or polyoxyalkyleneguanidine hydrochloride.
Preferably, the complex iodine comprises potassium iodate, iodine and povidone iodine.
Preferably, the surfactant is fatty alcohol polyvinyl chloride ether, alkylphenol polyoxyethylene ether or polyethylene glycol laurate.
The invention also provides a preparation method of the compound quaternary ammonium salt disinfectant, which comprises the following steps:
a) adding a surfactant into water, and uniformly stirring;
b) adding dioctyl dimethyl ammonium chloride and dodecyl dimethyl benzyl ammonium chloride into the mixed solution obtained in the step a), and uniformly stirring;
c) adding lauryl glucoside, glacial acetic acid, guanidine disinfectants, composite potassium iodate, chitosan hydrochloride, dibromohydantoin, hydrogenated hyperbranched polyolefin, moxifloxacin, allicin and beta-glucan palmitate into the mixed solution obtained in the step b), and uniformly mixing;
d) ultrafiltering the mixed solution obtained in the step c) by an ultrafiltration membrane to obtain the product.
Preferably, the nanofiltration membrane is a PVDF nanofiltration membrane.
Preferably, the molecular weight cut-off of the nanofiltration membrane is 500-800D.
The invention provides a compound quaternary ammonium salt disinfectant and a preparation method thereof, the compound quaternary ammonium salt disinfectant is prepared by taking dioctyldimethylammonium chloride, dodecyl dimethyl benzyl ammonium chloride, lauryl glucoside, glacial acetic acid, guanidine disinfectant, surfactant, compound potassium iodate, chitosan hydrochloride, dibromohydantoin, hydrogenated hyperbranched polyolefin, moxifloxacin, garlicin and beta-glucan palmitate as raw materials, can effectively inhibit and kill staphylococcus aureus, escherichia coli and candida albicans, can improve the killing efficiency of the compound quaternary ammonium salt disinfectant, and enables the compound quaternary ammonium salt disinfectant to have high killing durability. In addition, the invention is used for disinfecting equipment, instruments, particularly medical instruments, the disinfection effect of the invention on the medical instruments can reach the disinfection effect of the glutaraldehyde disinfection product which is the mainstream product for disinfecting the medical instruments at present, and the invention does not damage the disinfected objects, has no pollution to the environment and does not corrode metal utensils and the like.
Detailed Description
The invention provides a compound quaternary ammonium salt disinfectant, which comprises the following raw materials in parts by weight:
20-30 parts of dioctyldimethylammonium chloride, 10-20 parts of dodecyldimethylbenzylammonium chloride, 2-4 parts of lauryl glucoside, 1-2 parts of glacial acetic acid, 3-5 parts of guanidine disinfectant, 20-40 parts of surfactant, 7-10 parts of potassium iodate, 3-5 parts of chitosan hydrochloride, 1-2 parts of dibromohydantoin, 1-2 parts of hydrogenated hyperbranched polyolefin, 1-2 parts of moxifloxacin, 2-3 parts of allicin, 1-2 parts of beta-glucan palmitate and 50-60 parts of distilled water.
According to the invention, the compound quaternary ammonium salt disinfectant prepared by taking the dioctyldimethylammonium chloride, the dodecyldimethylbenzylammonium chloride, the lauryl glucoside, the glacial acetic acid, the guanidine disinfectant, the surfactant, the compound potassium iodate, the chitosan hydrochloride, the dibromohydantoin, the hydrogenated hyperbranched polyolefin, the moxifloxacin, the allicin and the beta-glucan palmitate as raw materials can effectively inhibit and kill staphylococcus aureus, escherichia coli and candida albicans, can improve the killing efficiency of the compound quaternary ammonium salt disinfectant, and enables the compound quaternary ammonium salt disinfectant to have high killing durability. In addition, the invention is used for disinfecting equipment, instruments, particularly medical instruments, the disinfection effect of the invention on the medical instruments can reach the disinfection effect of the glutaraldehyde disinfection product which is the mainstream product for disinfecting the medical instruments at present, and the invention does not damage the disinfected objects, has no pollution to the environment and does not corrode metal utensils and the like.
The dioctyl dimethyl ammonium chloride, dodecyl dimethyl benzyl ammonium chloride and guanidine disinfectant generate synergistic effect, so that the composite quaternary ammonium salt disinfectant has high bactericidal capacity.
In the embodiment of the invention, the weight part of the dioctyldimethylammonium chloride is 20-30 parts; in a preferred embodiment, the weight part of the dioctyldimethylammonium chloride is 23-27 parts; in other embodiments, the weight portion of dioctyldimethylammonium chloride is 25 parts.
In the embodiment of the invention, the weight part of the dodecyl dimethyl benzyl ammonium chloride is 10-20 parts; in a preferred embodiment, the weight part of the dodecyl dimethyl benzyl ammonium chloride is 15-20 parts; in other embodiments, the parts by weight of dodecyl dimethyl benzyl ammonium chloride is 15 parts.
In the embodiment of the invention, the weight part of lauryl glucoside is 2-4 parts; in a preferred embodiment, the weight part of lauryl glucoside is 2-3 parts; in other embodiments, the parts by weight of lauryl glucoside is 3 parts.
In the embodiment of the invention, the weight part of the glacial acetic acid is 1-2 parts; in a preferred embodiment, the weight part of the glacial acetic acid is 1-2 parts; in other embodiments, the parts by weight of glacial acetic acid is 1 part.
In the embodiment of the present invention, the guanidine disinfectant is polyhexamethylene biguanide hydrochloride, polyhexamethylene guanidine propionate or polyoxyalkyleneguanidine hydrochloride
In the embodiment of the invention, the guanidine disinfectant is 3-5 parts by weight; in a preferred embodiment, the guanidine disinfectant is 3-4 parts by weight; in other embodiments, the guanidine disinfectant is present in an amount of 4 parts by weight.
In the embodiment of the invention, the weight part of the surfactant is 20-40 parts; in a preferred embodiment, the weight part of the surfactant is 25-35 parts; in other embodiments, the weight fraction of surfactant is 30 parts.
In the embodiment of the invention, the surfactant is fatty alcohol polyvinyl chloride ether, alkylphenol polyoxyethylene ether or polyethylene glycol laurate. The surfactant can improve the cleaning and sterilizing effects of the compound quaternary ammonium salt disinfectant on medical instruments.
In the embodiment of the invention, the weight part of the composite potassium iodate is 7-10 parts; in a preferred embodiment, the weight part of the composite potassium iodate is 8-10 parts; in other embodiments, the weight portion of the potassium iodate complex is 8 parts.
Wherein the compound iodine comprises potassium iodate, iodine and povidone iodine; the mass ratio of the potassium iodate to the iodine to the povidone iodine is 1: (0.5-0.6): (2-3); the compound iodine can improve the sterilization effect of the compound quaternary ammonium salt disinfectant.
The chitosan hydrochloride and the beta-glucan palmitate can enable the compound quaternary ammonium salt disinfectant to be easy to form a film, and the compound quaternary ammonium salt disinfectant is beneficial to sterilizing medical supplies and improving the sterilization efficiency. In the embodiment of the invention, the weight part of the chitosan hydrochloride is 3-5 parts; in a preferred embodiment, the weight part of the chitosan hydrochloride is 3-4 parts; in other embodiments, the chitosan hydrochloride is 4 parts by weight.
In the embodiment of the invention, the weight part of the dibromohydantoin is 1-2 parts; in a preferred embodiment, the weight part of the dibromohydantoin is 1.5 to 2 parts; in other embodiments, the weight portion of dibromohydantoin is 2 parts.
The hydrogenated hyperbranched polyolefin can improve the killing stability of the compound quaternary ammonium salt disinfectant. In the embodiment of the invention, the weight part of the hydrogenated hyperbranched polyolefin is 1-2 parts; in a preferred embodiment, the weight part of the hydrogenated hyperbranched polyolefin is 1-1.5 parts; in other embodiments, the hydrogenated hyperbranched polyolefin is 1 part by weight.
The moxifloxacin increases the binding capacity of the compound quaternary ammonium salt disinfectant to bacteria and the penetrating power of cell membranes, and the antibacterial effect is strong and durable. In the embodiment of the invention, the weight part of the moxifloxacin is 1-2 parts; in a preferred embodiment, the weight part of the moxifloxacin is 1-2 parts; in other embodiments, the parts by weight of moxifloxacin is 2 parts.
In the embodiment of the invention, the weight part of the allicin is 2-3 parts; in a preferred embodiment, the weight part of the allicin is 2.5-3 parts; in other embodiments, the allicin is present in an amount of 3 parts by weight.
In the embodiment of the invention, the weight part of the beta-glucan palmitate is 1-2 parts; in a preferred embodiment, the weight part of the beta-glucan palmitate is 1-1.5 parts; in other embodiments, the weight fraction of β -glucan palmitate is 1.5 parts.
In the embodiment of the invention, the weight part of the distilled water is 50-60 parts; in a preferred embodiment, the weight part of the distilled water is 50-55 parts; in other embodiments, the distilled water is 50 parts by weight.
The invention also provides a preparation method of the compound quaternary ammonium salt disinfectant, which comprises the following steps:
a) adding a surfactant into water, and uniformly stirring;
b) adding dioctyl dimethyl ammonium chloride and dodecyl dimethyl benzyl ammonium chloride into the mixed solution obtained in the step a), and uniformly stirring;
c) adding lauryl glucoside, glacial acetic acid, guanidine disinfectants, composite potassium iodate, chitosan hydrochloride, dibromohydantoin, hydrogenated hyperbranched polyolefin, moxifloxacin, allicin and beta-glucan palmitate into the mixed solution obtained in the step b), and uniformly mixing;
d) ultrafiltering the mixed solution obtained in the step c) by an ultrafiltration membrane to obtain the product.
Among them, dioctyldimethylammonium chloride, dodecyldimethylbenzylammonium chloride, lauryl glucoside, glacial acetic acid, guanidine disinfectant, surfactant, potassium iodate complex, chitosan hydrochloride, dibromohydantoin, hydrogenated hyperbranched polyolefin, moxifloxacin, allicin, beta-glucan palmitate, and distilled water are the same as above, and are not described again here.
In an embodiment of the invention, the nanofiltration membrane is a PVDF nanofiltration membrane. Wherein the cut-off molecular weight of the nanofiltration membrane is 500-800D
In order to further illustrate the present invention, the following examples are provided to describe the method for preparing high purity fructo-oligosaccharide from sucrose in detail, but they should not be construed as limiting the scope of the present invention.
Example 1
The compound quaternary ammonium salt disinfectant comprises the following raw materials in parts by weight:
30 parts of dioctyldimethylammonium chloride, 10 parts of dodecyl dimethylbenzyl ammonium chloride, 3 parts of lauryl glucoside, 1 part of glacial acetic acid, 3 parts of polyhexamethylene biguanide hydrochloride, 20 parts of alkylphenol polyoxyethylene, 7 parts of composite potassium iodate, 3 parts of chitosan hydrochloride, 2 parts of dibromohydantoin, 1 part of hydrogenated hyperbranched polyolefin, 1 part of moxifloxacin, 2 parts of allicin, 1 part of beta-glucan palmitate and 50 parts of distilled water.
The composite iodine comprises the following components in percentage by mass: 0.5: potassium iodate, iodine, and povidone iodine.
The preparation method of the compound quaternary ammonium salt disinfectant comprises the following steps:
a) adding alkylphenol polyoxyethylene into water and stirring uniformly;
b) adding dioctyl dimethyl ammonium chloride and dodecyl dimethyl benzyl ammonium chloride into the mixed solution obtained in the step a), and uniformly stirring;
c) adding lauryl glucoside, glacial acetic acid, polyhexamethylene biguanide hydrochloride, composite potassium iodate, chitosan hydrochloride, dibromohydantoin, hydrogenated hyperbranched polyolefin, moxifloxacin, allicin and beta-glucan palmitate into the mixed solution obtained in the step b), and uniformly mixing;
d) and c) passing the mixed solution obtained in the step c) through a PVDF nanofiltration membrane with the molecular weight cutoff of 500D to obtain the compound quaternary ammonium salt disinfectant.
The stainless steel sheet, the copper sheet and the aluminum sheet are placed into the composite quaternary ammonium salt disinfectant prepared in the embodiment 1 and soaked for 10 days, and no corrosion phenomenon is caused.
Example 2
The compound quaternary ammonium salt disinfectant comprises the following raw materials in parts by weight:
27 parts of dioctyldimethylammonium chloride, 20 parts of dodecyl dimethylbenzyl ammonium chloride, 4 parts of lauryl glucoside, 2 parts of glacial acetic acid, 4 parts of polyoxy alkylene guanidine hydrochloride, 35 parts of fatty alcohol polyvinyl chloride ether, 8 parts of composite potassium iodate, 4 parts of chitosan hydrochloride, 1.5 parts of dibromohydantoin, 2 parts of hydrogenated hyperbranched polyolefin, 2 parts of moxifloxacin, 3 parts of allicin, 2 parts of beta-glucan palmitate and 55 parts of distilled water.
The composite iodine comprises the following components in percentage by mass: 0.6: potassium iodate, iodine, and povidone iodine.
The preparation method of the compound quaternary ammonium salt disinfectant comprises the following steps:
a) adding fatty alcohol-polyvinyl chloride ether into water and stirring uniformly;
b) adding dioctyl dimethyl ammonium chloride and dodecyl dimethyl benzyl ammonium chloride into the mixed solution obtained in the step a), and uniformly stirring;
c) adding lauryl glucoside, glacial acetic acid, polyoxy alkylene guanidine hydrochloride, composite potassium iodate, chitosan hydrochloride, dibromohydantoin, hydrogenated hyperbranched polyolefin, moxifloxacin, allicin and beta-glucan palmitate into the mixed solution obtained in the step b), and uniformly mixing;
d) and c) passing the mixed solution obtained in the step c) through a PVDF nanofiltration membrane with the molecular weight cutoff of 700D to obtain the compound quaternary ammonium salt disinfectant.
The stainless steel sheet, the copper sheet and the aluminum sheet are placed into the composite quaternary ammonium salt disinfectant prepared in the embodiment 2 and soaked for 10 days, and no corrosion phenomenon is caused.
Example 3
The compound quaternary ammonium salt disinfectant comprises the following raw materials in parts by weight:
23 parts of dioctyldimethylammonium chloride, 15 parts of dodecyldimethylbenzylammonium chloride, 2 parts of lauryl glucoside, 2 parts of glacial acetic acid, 5 parts of polyhexamethylene biguanide hydrochloride, 40 parts of polyethylene glycol laurate, 10 parts of composite potassium iodate, 5 parts of chitosan hydrochloride, 2 parts of dibromohydantoin, 1.5 parts of hydrogenated hyperbranched polyolefin, 1 part of moxifloxacin, 2.5 parts of allicin, 1.5 parts of beta-glucan palmitate and 65 parts of distilled water.
The composite iodine comprises the following components in percentage by mass: 0.6: potassium iodate, iodine, and povidone iodine.
The preparation method of the compound quaternary ammonium salt disinfectant comprises the following steps:
a) adding polyethylene glycol laurate into water and stirring uniformly;
b) adding dioctyl dimethyl ammonium chloride and dodecyl dimethyl benzyl ammonium chloride into the mixed solution obtained in the step a), and uniformly stirring;
c) adding lauryl glucoside, glacial acetic acid, polyhexamethylene biguanide hydrochloride, composite potassium iodate, chitosan hydrochloride, dibromohydantoin, hydrogenated hyperbranched polyolefin, moxifloxacin, allicin and beta-glucan palmitate into the mixed solution obtained in the step b), and uniformly mixing;
d) and c) passing the mixed solution obtained in the step c) through a PVDF nanofiltration membrane with the molecular weight cutoff of 600D to obtain the compound quaternary ammonium salt disinfectant.
The stainless steel sheet, the copper sheet and the aluminum sheet are placed into the composite quaternary ammonium salt disinfectant prepared in the embodiment 3 and soaked for 10 days, and no corrosion phenomenon is caused.
Example 4
The compound quaternary ammonium salt disinfectant comprises the following raw materials in parts by weight:
20 parts of dioctyldimethylammonium chloride, 15 parts of dodecyl dimethylbenzyl ammonium chloride, 3 parts of lauryl glucoside, 2 parts of glacial acetic acid, 4 parts of polyhexamethylene guanidine propionate, 25 parts of fatty alcohol polyvinyl chloride ether, 8 parts of composite potassium iodate, 4 parts of chitosan hydrochloride, 1 part of dibromohydantoin, 1 part of hydrogenated hyperbranched polyolefin, 2 parts of moxifloxacin, 3 parts of allicin, 1.5 parts of beta-glucan palmitate and 50 parts of distilled water.
The composite iodine comprises the following components in percentage by mass: 0.6: 2.5 Potassium iodate, iodine and Povidone iodine.
The preparation method of the compound quaternary ammonium salt disinfectant comprises the following steps:
a) adding the fatty alcohol-polyvinyl chloride ether into water and uniformly stirring;
b) adding dioctyl dimethyl ammonium chloride and dodecyl dimethyl benzyl ammonium chloride into the mixed solution obtained in the step a), and uniformly stirring;
c) adding lauryl glucoside, glacial acetic acid, polyhexamethylene guanidine propionate, composite potassium iodate, chitosan hydrochloride, dibromohydantoin, hydrogenated hyperbranched polyolefin, moxifloxacin, allicin and beta-glucan palmitate into the mixed solution obtained in the step b), and uniformly mixing;
d) and c) passing the mixed solution obtained in the step c) through a PVDF nanofiltration membrane with the molecular weight cutoff of 800D to obtain the compound quaternary ammonium salt disinfectant.
The stainless steel sheet, the copper sheet and the aluminum sheet are placed into the composite quaternary ammonium salt disinfectant prepared in the embodiment 4 and soaked for 10 days, and no corrosion phenomenon is caused.
Example 5
The compound quaternary ammonium salt disinfectant comprises the following raw materials in parts by weight:
25 parts of dioctyldimethylammonium chloride, 15 parts of dodecyl dimethylbenzyl ammonium chloride, 3 parts of lauryl glucoside, 1 part of glacial acetic acid, 4 parts of polyoxy alkylene guanidine hydrochloride, 30 parts of alkylphenol polyoxyethylene, 8 parts of composite potassium iodate, 4 parts of chitosan hydrochloride, 2 parts of dibromohydantoin, 1 part of hydrogenated hyperbranched polyolefin, 2 parts of moxifloxacin, 3 parts of allicin, 1.5 parts of beta-glucan palmitate and 50 parts of distilled water.
The composite iodine comprises the following components in percentage by mass: 0.55: 2.5 Potassium iodate, iodine and Povidone iodine.
The preparation method of the compound quaternary ammonium salt disinfectant comprises the following steps:
a) adding alkylphenol polyoxyethylene into water and stirring uniformly;
b) adding dioctyl dimethyl ammonium chloride and dodecyl dimethyl benzyl ammonium chloride into the mixed solution obtained in the step a), and uniformly stirring;
c) adding lauryl glucoside, glacial acetic acid, polyoxy alkylene guanidine hydrochloride, composite potassium iodate, chitosan hydrochloride, dibromohydantoin, hydrogenated hyperbranched polyolefin, moxifloxacin, allicin and beta-glucan palmitate into the mixed solution obtained in the step b), and uniformly mixing;
d) and c) passing the mixed solution obtained in the step c) through a PVDF nanofiltration membrane with the molecular weight cutoff of 500D to obtain the compound quaternary ammonium salt disinfectant.
The stainless steel sheet, the copper sheet and the aluminum sheet are placed into the composite quaternary ammonium salt disinfectant prepared in the example 5 and soaked for 10 days, and no corrosion phenomenon is caused.
The composite quaternary ammonium salt disinfectants prepared in the embodiments 1 to 5 are respectively prepared into 0.25% aqueous solutions by using water, wherein a control group is obtained by using an iodophor disinfectant of rilokang, and staphylococcus aureus, escherichia coli and candida albicans are subjected to sterilization tests for different times (10min and 20min) by adopting a method of 2012 edition "medical institution sterilization technical specification", and the killing logarithm value is calculated, and the results are shown in table 1.
And the medical instruments sterilized for 20min were placed in the air for the test of the durability of killing, and the results are shown in table 2.
TABLE 1 kill rates for examples 1-5 and control
As can be seen from Table 1, the compound quaternary ammonium salt disinfectant prepared by the invention has good killing rate on staphylococcus aureus, escherichia coli and candida albicans, and the killing rate is higher than that of a control group.
TABLE 2 results of the test for the durability of killing of examples 1 to 5 and the control group
As can be seen from Table 2, the compound quaternary ammonium salt disinfectant prepared by the invention has good killing durability.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (9)
1. The compound quaternary ammonium salt disinfectant is characterized by comprising the following raw materials in parts by weight:
20-30 parts of dioctyldimethylammonium chloride, 10-20 parts of dodecyldimethylbenzylammonium chloride, 2-4 parts of lauryl glucoside, 1-2 parts of glacial acetic acid, 3-5 parts of guanidine disinfectant, 20-40 parts of surfactant, 7-10 parts of potassium iodate, 3-5 parts of chitosan hydrochloride, 1-2 parts of dibromohydantoin, 1-2 parts of hydrogenated hyperbranched polyolefin, 1-2 parts of moxifloxacin, 2-3 parts of allicin, 1-2 parts of beta-glucan palmitate and 50-60 parts of distilled water.
2. The compound quaternary ammonium salt disinfectant as claimed in claim 1, which is characterized by comprising the following raw materials in parts by weight:
23-27 parts of dioctyldimethylammonium chloride, 15-20 parts of dodecyl dimethyl benzyl ammonium chloride, 2-3 parts of lauryl glucoside, 1-2 parts of glacial acetic acid, 3-4 parts of guanidine disinfectant, 25-35 parts of surfactant, 8-10 parts of potassium iodate complex, 4-5 parts of chitosan hydrochloride, 1.5-2 parts of dibromohydantoin, 1-1.5 parts of hydrogenated hyperbranched polyolefin, 1-2 parts of moxifloxacin, 2.5-3 parts of allicin, 1-1.5 parts of beta-glucan palmitate and 50-55 parts of distilled water.
3. The compound quaternary ammonium salt disinfectant as claimed in claim 1, which is characterized by comprising the following raw materials in parts by weight:
25 parts of dioctyldimethylammonium chloride, 15 parts of dodecyl dimethylbenzyl ammonium chloride, 3 parts of lauryl glucoside, 1 part of glacial acetic acid, 4 parts of guanidine disinfectant, 30 parts of surfactant, 8 parts of composite potassium iodate, 4 parts of chitosan hydrochloride, 2 parts of dibromohydantoin, 1 part of hydrogenated hyperbranched polyolefin, 2 parts of moxifloxacin, 3 parts of allicin, 1.5 parts of beta-glucan palmitate and 50 parts of distilled water.
4. The compound quaternary ammonium salt disinfectant according to claim 1, wherein the guanidine disinfectant is polyhexamethylene biguanide hydrochloride, polyhexamethylene guanidine propionate or polyoxyalkyleneguanidine hydrochloride.
5. The compound quaternary ammonium salt disinfectant according to claim 1, wherein the compound iodine comprises potassium iodate, iodine and povidone-iodine.
6. The compound quaternary ammonium salt disinfectant as set forth in claim 1, wherein the surfactant is fatty alcohol polyvinyl chloride ether, alkylphenol polyoxyethylene ether or polyethylene glycol laurate.
7. The method for preparing the compound quaternary ammonium salt disinfectant according to claim 1, which is characterized by comprising the following steps:
a) adding a surfactant into water, and uniformly stirring;
b) adding dioctyl dimethyl ammonium chloride and dodecyl dimethyl benzyl ammonium chloride into the mixed solution obtained in the step a), and uniformly stirring;
c) adding lauryl glucoside, glacial acetic acid, guanidine disinfectants, composite potassium iodate, chitosan hydrochloride, dibromohydantoin, hydrogenated hyperbranched polyolefin, moxifloxacin, allicin and beta-glucan palmitate into the mixed solution obtained in the step b), and uniformly mixing;
d) ultrafiltering the mixed solution obtained in the step c) by an ultrafiltration membrane to obtain the product.
8. The method of claim 7, wherein the nanofiltration membrane is a PVDF nanofiltration membrane.
9. The preparation method of claim 7, wherein the nanofiltration membrane has a molecular weight cut-off of 500-800D.
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Application publication date: 20191220 |
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