CN110534396B - Composite mass spectrometry ion source device - Google Patents
Composite mass spectrometry ion source device Download PDFInfo
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- CN110534396B CN110534396B CN201910674782.XA CN201910674782A CN110534396B CN 110534396 B CN110534396 B CN 110534396B CN 201910674782 A CN201910674782 A CN 201910674782A CN 110534396 B CN110534396 B CN 110534396B
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- 239000002131 composite material Substances 0.000 title claims abstract description 16
- 238000004949 mass spectrometry Methods 0.000 title claims abstract description 9
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims abstract description 48
- 238000010438 heat treatment Methods 0.000 claims abstract description 29
- 150000002500 ions Chemical class 0.000 claims description 163
- 230000007935 neutral effect Effects 0.000 claims description 25
- 239000007921 spray Substances 0.000 claims description 16
- 239000002699 waste material Substances 0.000 claims description 12
- 238000009434 installation Methods 0.000 claims description 10
- 230000001105 regulatory effect Effects 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 7
- 230000008016 vaporization Effects 0.000 claims description 7
- 239000003595 mist Substances 0.000 claims description 6
- 238000005507 spraying Methods 0.000 claims description 6
- 238000000034 method Methods 0.000 abstract description 4
- 230000008569 process Effects 0.000 abstract description 3
- 238000001819 mass spectrum Methods 0.000 description 12
- 102000004310 Ion Channels Human genes 0.000 description 7
- 238000007599 discharging Methods 0.000 description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- 238000003780 insertion Methods 0.000 description 4
- 230000037431 insertion Effects 0.000 description 4
- 239000002912 waste gas Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 238000009834 vaporization Methods 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 150000002605 large molecules Chemical class 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Classifications
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/107—Arrangements for using several ion sources
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
- H01J49/165—Electrospray ionisation
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
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- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Plasma & Fusion (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Abstract
本发明公开了一种复合型质谱离子源装置，包括：离子源、辅助加热装置、离子源支架、调节装置及腔体；离子源支架安装于腔体上；离子源包括有电喷雾离子源及大气压化学电离源，电喷雾离子源及大气压化学电离源之间通过离子源支架相互替换安装于所述腔体上，辅助加热装置以及调节装置被安装于所述腔体上；腔体的内部中空，腔体的内部具有电离区域，离子源支架、辅助加热装置的朝向方向均朝向电离区域。本发明要解决的技术问题是，电喷雾离子源及大气压化学电离源能够同时兼容并相互替换安装在同一个腔体上，企业在设备采购过程中，只需采购一种设备，便能拥有电喷雾离子源及大气压化学电离源这两种功能，极大地减少了企业的购置成本。
The present invention discloses a composite mass spectrometry ion source device, comprising: an ion source, an auxiliary heating device, an ion source bracket, an adjusting device and a cavity; the ion source bracket is installed on the cavity; the ion source comprises an electrospray ion source and an atmospheric pressure chemical ionization source, the electrospray ion source and the atmospheric pressure chemical ionization source are installed on the cavity by replacing each other through the ion source bracket, and the auxiliary heating device and the adjusting device are installed on the cavity; the interior of the cavity is hollow, the interior of the cavity has an ionization region, and the ion source bracket and the auxiliary heating device are both oriented toward the ionization region. The technical problem to be solved by the present invention is that the electrospray ion source and the atmospheric pressure chemical ionization source can be compatible and installed on the same cavity by replacing each other. In the process of equipment procurement, enterprises only need to purchase one type of equipment to have the two functions of the electrospray ion source and the atmospheric pressure chemical ionization source, which greatly reduces the purchase cost of the enterprise.
Description
Technical Field
The invention belongs to the technical field of mass spectrometer equipment, and particularly relates to a composite mass spectrum ion source device.
Background
The triple quadrupole mass spectrum is a chemical analysis instrument with very large market demand, has the characteristics of high precision, high research and development manufacturing difficulty, wide market demand, high instrument value and import reliability, and is mainly applied to the fields of food, medicine and health, accurate medical treatment, judicial identification, industrial analysis and the like. In a triple quadrupole mass spectrometer, the ion source device has the function of converting a detection sample from neutral molecules into charged ions, and the ion source has great influence on the signal sensitivity and the signal stability of the mass spectrometer.
The common triple quadrupole mass spectrum has two ion source devices, namely an electrospray ion source (ESI) device and an atmospheric pressure chemical ionization source (APCI) device, and an enterprise needs to purchase the electrospray ion source and the atmospheric pressure chemical ionization source ion source as two different split devices when purchasing the devices, so that the purchase cost of the enterprise is increased. The conventional ion source has a vertical orthogonal design of spray direction and interface, and the disadvantage of such a design is that the ion loss is more and the ratio of ion conversion to interface is lower.
Disclosure of Invention
The invention aims to solve the technical problems that an electrospray ion source and an atmospheric pressure chemical ionization source can be compatible and mutually replaced and installed on the same cavity, and an enterprise can have two functions of the electrospray ion source and the atmospheric pressure chemical ionization source only by purchasing one type of equipment in the equipment purchasing process, so that the purchasing cost of the enterprise is greatly reduced.
The technical scheme is as follows:
The composite mass spectrum ion source device comprises an ion source, an auxiliary heating device, an ion source bracket, an adjusting device and a cavity;
the ion source is used for ejecting neutral molecules of the liquid sample, releasing charges to the heated and vaporized neutral molecules, and converting the heated and vaporized neutral molecules into charged ions after carrying charges;
The auxiliary heating device is used for heating and vaporizing the ejected neutral molecules;
the ion source is arranged on the ion source bracket;
The adjusting device is used for adjusting the installation position and direction of the ion source bracket, and the ion source bracket is installed on the cavity;
The ion source comprises an electrospray ion source and an atmospheric pressure chemical ionization source, the electrospray ion source and the atmospheric pressure chemical ionization source are mutually arranged on the cavity in a replacement way through an ion source bracket, and the auxiliary heating device and the regulating device are arranged on the cavity;
the inside of the cavity is hollow, an ionization region is arranged in the cavity, and the direction of the ion source bracket and the direction of the auxiliary heating device face the ionization region.
Further, the electrospray ion source and the atmospheric pressure chemical ionization source are both provided with spray needles for spraying mist droplets, and the atmospheric pressure chemical ionization source is provided with high-voltage discharge needles for releasing charges.
Further, the cavity comprises a top and a bottom, the top and the bottom are opposite, the adjusting device is arranged on the top, and the ionization region is positioned above the bottom;
the bottom comprises a flat plate and two inclined plates, wherein the inclined plates are respectively positioned at two sides of the flat plate, the cross sections of the flat plate and the inclined plates in the vertical direction are gradually concave along the direction from the inclined plate to the flat plate, and the inclined plates are positioned above the flat plate.
Further, the auxiliary heating device comprises a first heater and a second heater, wherein the first heater is installed at the bottom of the cavity, and the second heater is installed on the ion source support.
Further, the top is provided with a jack, the ion source support is hinged to the jack through the adjusting device and penetrates through the jack, the flat plate and the inclined plate are provided with mounting holes, the number of the first heaters is two, and the two first heaters are matched with the mounting holes of the corresponding inclined plate respectively.
Further, the device also comprises a waste discharging device, and the waste discharging device is matched with the mounting hole of the flat plate.
Further, in the direction of the cross sections of the flat plate and the inclined plate, the two first heaters are symmetrical with each other with the longitudinal central axis perpendicular to the flat plate as a symmetry axis.
Further, the cavity further comprises a side plate, and the side plate is provided with an observation window which corresponds to the ionization region.
Further, the ion source support is mounted on the top in an inclined manner, the first heater is in inclined fit with the mounting hole, and the inclination direction of the second heater is consistent with that of the ion source support.
Further, the inclination direction of the ion source support is inclined downwards in the vertical direction, the orientation direction of the first heater is inclined upwards in the vertical direction, and the inclination directions of the ion source support and the first heater are both towards the ionization region
It should be noted that:
1. The English of the electrospray ion source is abbreviated as ESI, and the English of the atmospheric pressure chemical ionization source is abbreviated as APCI.
2. The auxiliary heating device sprays high-temperature hot air.
3. The foregoing "first and second" do not denote a particular quantity or order, but rather are used to distinguish one name from another.
4. The term "mounted" is to be understood broadly, and may be, for example, fixedly connected, detachably connected, integrally connected, directly connected, or indirectly connected via an intermediate medium. The specific meaning of the above terms in the present invention will be understood in specific cases by those of ordinary skill in the art.
The advantages and principles of the invention are described below:
The electrospray ion source and the atmospheric pressure chemical ionization source of the ion source bracket are mutually and alternately arranged on the cavity through the ion source bracket, when the electrospray ion source is required to be used, the electrospray ion source is arranged on the ion source bracket, and the ion source bracket is hinged and arranged on the cavity through the adjusting device, so that the electrospray ion source is sprayed in the cavity and converted into charged ions; when the atmospheric pressure chemical ionization source is needed, the electrospray ion source and the ion source support are detached from the cavity, and then the ion source support provided with the atmospheric pressure chemical ionization source is replaced and installed on the cavity, so that the electrospray ion source is sprayed in the cavity and converted into charged ions, and an enterprise can use two different functions by purchasing one ion source device when purchasing the device, and does not need to purchase two different devices at the same time, thereby greatly reducing the equipment investment cost of the enterprise.
Drawings
FIG. 1 is a schematic diagram of the physical structure of a composite mass spectrometry ion source device according to an embodiment of the present invention;
FIG. 2 is a cross-sectional view of a composite mass spectrometry ion source device according to an embodiment of the present invention;
FIG. 3 is a front view of a composite mass spectrometry ion source device according to an embodiment of the present invention;
FIG. 4 is a front view of an electrospray ion source of an embodiment of the present invention mounted on an ion source holder;
FIG. 5 is a partial cross-sectional view of FIG. 4;
Fig. 6 is a front view of an ion source holder according to an embodiment of the invention;
FIG. 7 is a front view of an electrospray ion source according to an embodiment of the present invention;
FIG. 8 is a front view of an atmospheric pressure chemical ionization source mounted on an ion source holder according to an embodiment of the present invention;
FIG. 9 is a front view of an atmospheric pressure chemical ionization source according to an embodiment of the present invention;
Reference numerals illustrate:
10. The device comprises a cavity, 11, an ionization region, 12, side plates, 13, an observation window, 20, a top, 21, an insertion hole, 30, a bottom, 31, a flat plate, 32, an inclined plate, 33, a mounting hole, 40, an ion source bracket, 41, an ion source, 42, an electrospray ion source, 43, an atmospheric pressure chemical ionization source, 44, a spray needle, 45, a discharge needle, 50, an auxiliary heating device, 51, a first heater, 52, a second heater, 60, a regulating device, 70, a waste discharging device, 80 and an ion channel.
Detailed Description
The following describes embodiments of the present invention in detail.
As shown in fig. 1 to 3, the composite mass spectrometry ion source device comprises an ion source 41, an auxiliary heating device 50, an ion source support 40, a regulating device 60 and a cavity 10, wherein the ion source 41 is used for ejecting neutral molecules of a liquid sample and discharging charges on the heated and vaporized neutral molecules to enable the heated and vaporized neutral molecules to be charged and converted into charged ions, the auxiliary heating device 50 is used for heating and vaporizing the ejected neutral molecules, the ion source support 40 is arranged on the ion source support 40, the regulating device 60 is used for regulating the installation position and direction of the ion source support 40, the ion source support 40 is arranged on the cavity 10, the ion source 41 comprises an electrospray ion source 42 and an atmospheric pressure chemical ionization source 43, the electrospray ion source 42 and the atmospheric pressure chemical ionization source 43 are mutually arranged on the cavity 10 in a replacement mode through the ion source support 40, the auxiliary heating device 50 and the regulating device 60 are arranged on the cavity 10, the inside of the cavity 10 is hollow, an ionization region 11 is arranged in the cavity 10, and the direction of the ion source support 40 and the auxiliary heating device 50 faces the region 11.
Referring to fig. 4 to 9, the electrospray ion source 42 and the atmospheric pressure chemical ionization source 43 are both provided with a spray needle 44 for spraying mist droplets, the atmospheric pressure chemical ionization source 43 is provided with a high voltage discharge needle 45 for discharging charges, the auxiliary heating device 50 comprises a first heater 51 and a second heater 52, the first heater 51 is mounted on the bottom 30 of the chamber 10, and the second heater 52 is mounted on the ion source support 40.
Referring to fig. 2 and 3, the chamber 10 includes a top 20 and a bottom 30, the top 20 and the bottom 30 are opposite, an adjusting device 60 is mounted on the top 20, the ionization region 11 is located above the bottom 30, the bottom 30 includes a flat plate 31 and two inclined plates 32, the inclined plates 32 are respectively located at two sides of the flat plate 31, cross sections of the flat plate 31 and the inclined plates 32 in a vertical direction are gradually recessed along a direction from the inclined plates 32 to the flat plate 31, the inclined plates 32 are located above the flat plate 31, the top 20 is provided with an insertion hole 21, an ion source support 40 is hinged on the insertion hole 21 through the adjusting device 60, the ion source support 40 penetrates through the insertion hole 21, the flat plate 31 and the inclined plates 32 are respectively provided with mounting holes 33, the number of the first heaters 51 is two, the two first heaters 51 are respectively matched with the mounting holes 33 corresponding to the inclined plates 32, and the two first heaters 51 are mutually symmetrical with each other by taking a longitudinal central axis perpendicular to the flat plate 31 as a symmetry axis in the direction of the cross sections of the flat plate 31 and the inclined plates 32.
Referring to fig. 1, the composite mass spectrometry ion source device further includes a waste discharge device 70, the waste discharge device 70 is matched with the mounting hole 33 of the flat plate 31, the cavity 10 further includes a side plate 12, the side plate 12 is provided with an observation window 13, and the observation window 13 corresponds to the ionization region 11.
Referring to fig. 1,2 and 3, the electrospray ion source 42 and the atmospheric pressure chemical ionization source 43 are mounted on the top 20 in an inclined manner, the first heater 51 is mated with the mounting hole 33 in an inclined manner, the inclination direction of the second heater 52 is consistent with the inclination direction of the atmospheric pressure chemical ionization source 43, the inclination direction of the ion source support 40 is inclined downward in the vertical direction, the orientation direction of the first heater 51 is inclined upward in the vertical direction, the inclination directions of the ion source support 40 and the first heater 51 are both oriented to the ionization region 11, and in this embodiment, the temperature range of the high-temperature hot gas ejected by the auxiliary heating device 50 is 640-660 degrees.
The application method of the composite mass spectrum ion source comprises the following steps:
When the compound mass spectrum ion source device ionizes compound molecules with medium polarity to strong polarity, using electrospray ion source 42 equipment, installing an electrospray ion source 42 on an ion source bracket 40, installing the ion source bracket 40 on a jack 21, adjusting the installation position and the orientation direction of the electrospray ion source 42 on the jack 21 through an adjusting device 60, and fixing the electrospray ion source 42 after the adjustment to the designated position and the designated direction;
The composite mass spectrum ion source device is started, the electrospray ion source 42 sprays charged neutral molecules of a liquid sample to the ionization region 11 through the charged spray needle 44, the first heater 51 of the auxiliary heating device 50 sprays high-temperature hot gas to the ionization region 11, the high-temperature hot gas heats the neutral molecules in the ionization region 11 to vaporize the charged neutral molecules and generate charged ions, the generated charged ions enter the ion channel 80, and uncharged neutral ions or other impurities after the neutral molecules are heated can be pumped away with the high-temperature hot gas through the waste discharge device 70 and discharged;
When the compound mass spectrum ion source device ionizes large molecules with less charge or poorer polarity, the electro-spray ion source 42 and the ion source bracket 40 are detached from the jack 21 by using the atmospheric pressure chemical ionization source 43 equipment, then the ion source bracket 40 provided with the atmospheric pressure chemical ionization source 43 is replaced and arranged on the jack 21, the installation position and the orientation direction of the atmospheric pressure chemical ionization source 43 are adjusted by the adjusting device 60, the atmospheric pressure chemical ionization source 43 is fixed after the specified installation position and orientation direction are adjusted, the discharge needle 45 is rotated, and the discharge direction of the discharge needle 45 is oriented to the position direction of the spray needle 44;
The composite mass spectrum ion source device is started, the atmospheric pressure chemical ionization source 43 sprays neutral molecules of a liquid sample through the spray needle 44, the second heater 52 of the auxiliary heating device 50 sprays high-temperature hot air, the high-temperature hot air heats the neutral molecules in the atmospheric pressure chemical ionization source 43 to enable atomized small liquid drops in the atmospheric pressure chemical ionization source 43 to be vaporized, the vaporized neutral molecules are blown out from the inside of the atmospheric pressure chemical ionization source 43 to the ionization region 11 through the high-temperature hot air, the discharge needle 45 releases charges to enable nitrogen or oxygen in the ionization region 11 to be charged, the charged nitrogen or oxygen transfers charges to gaseous solvent molecules, the charged gaseous solvent molecules transfer charges to the vaporized neutral molecules, charged ions are generated, the generated charged ions enter the ion channel 80, and uncharged neutral ions or other impurities are pumped away and discharged through the waste discharge device 70 together with the high-temperature hot air.
The above embodiment has the following advantages:
1. In the composite mass spectrum ion source device, an electrospray ion source 42 and an atmospheric pressure chemical ionization source 43 of an ion source support 40 are mutually replaced and arranged on a cavity 10 through the ion source support 40, when the electrospray ion source 42 is needed to be used, the electrospray ion source 42 is arranged on the ion source support 40, the ion source support 40 is hinged and arranged on the cavity 10 through a regulating device 60, so that the electrospray ion source 42 sprays inside the cavity 10 and converts the electrospray ion source 42 into charged ions, when the atmospheric pressure chemical ionization source 43 is needed to be used, the electrospray ion source 42 and the ion source support 40 are detached from the cavity 10, and then the ion source support 40 provided with the atmospheric pressure chemical ionization source 43 is replaced and arranged on the cavity 10, so that the electrospray ion source 42 sprays inside the cavity 10 and converts the electrospray ion source 42 into the charged ions.
2. The adjusting device 60 can adjust the installation position and the orientation direction of the ion source bracket 40, the ion source bracket 40 with the adjusted installation position and orientation direction is provided with neutral molecules of the liquid sample sprayed by the ion source 41, the auxiliary heating device 50 heats and gasifies the neutral molecules and generates charged ions, and the heated and gasified waste gas is separated in the ionization region 11, so that most of the charged ions in the ionization region 11 enter the ion channel 80, and the waste gas and unconverted impurities are prevented from entering the ion channel 80, thereby not only improving the pollution resistance and durability of the mass spectrometer, but also improving the transmission efficiency of the charged ions, and ensuring the service performance of the composite mass spectrum ion source device in the mass spectrometer.
3. The arrangement of the angular positions of the flat plate 31 and the inclined plate 32 is used for fixing the installation positions and the orientation directions of the first heater 51 and the waste discharging device 70 when the first heater 51 and the waste discharging device 70 are installed, so that the vaporization effect of the first heater 51 on the sprayed mist droplets is better and more obvious, more charged ions can be converted, and the conversion rate of the charged ions is further improved.
4. The two first heaters 51 which are symmetrical to each other can jointly heat and vaporize the sprayed mist droplets, and further improve the efficiency of heating and vaporizing.
5. The electrospray ion source 42 and the atmospheric pressure chemical ionization source 43 are mutually replaced and installed on the jack 21 through the ion source bracket 40, two spraying modes of the electrospray ion source 42 equipment corresponding to the electrospray ion source 42 and the atmospheric pressure chemical ionization source 43 equipment corresponding to the atmospheric pressure chemical ionization source 43 are compatible and combined on the same cavity 10, the disassembly and replacement process is convenient and rapid, two different functions can be completed through one equipment, enterprises do not need to purchase two different equipment, and the equipment investment cost of the enterprises is greatly reduced.
6. The second heater 52 is different from the electrospray ion source 42 in the spraying mode on the atmospheric pressure chemical ionization source 43, when the ion source bracket 40 is assembled with the atmospheric pressure chemical ionization source 43 to work, the first heater 51 does not carry out heating vaporization treatment on mist droplets, and the second heater 52 carries out heating vaporization in the ion source bracket 40, so that the same cavity 10 can be well compatible with two spraying modes of the electrospray ion source 42 device of the first heater 51 and the atmospheric pressure chemical ionization source 43 device of the second heater 52.
7. The well-adjusted and fixed installation position and orientation direction of the ion source support 40 can enable the waste discharge device 7070 to accurately pump and discharge heated and atomized waste gas from the ionization region 11, so that the waste gas is separated from charged ions, the ion channel 80 is enabled to be charged with most of charged ions, the ion channel 80 is further prevented from blocking and polluting mass spectrometry instruments, and the service life of equipment is prolonged.
The above embodiments are only specific examples of the present invention, and the scope of the present invention is not limited thereto, and any substitutions and modifications made without departing from the spirit of the present invention are all within the scope of the present invention.
Claims (1)
1. A composite mass spectrometry ion source device comprising:
the ion source is used for ejecting neutral molecules of the liquid sample, releasing charges to the heated and vaporized neutral molecules, and converting the heated and vaporized neutral molecules into charged ions after carrying charges;
The auxiliary heating device is used for heating and vaporizing the ejected neutral molecules;
the ion source is arranged on the ion source bracket;
the ion source support is characterized by comprising an adjusting device and a cavity, wherein the adjusting device is used for adjusting the installation position and direction of the ion source support, and the ion source support is installed on the cavity;
The ion source comprises an electrospray ion source and an atmospheric pressure chemical ionization source, the electrospray ion source and the atmospheric pressure chemical ionization source are mutually arranged on the cavity in a replacement way through an ion source bracket, and the auxiliary heating device and the regulating device are arranged on the cavity;
The inside of the cavity is hollow, an ionization area is arranged in the cavity, and the direction of the ion source bracket and the direction of the auxiliary heating device face the ionization area;
The electrospray ion source and the atmospheric pressure chemical ionization source are both provided with spray needles for spraying mist droplets, and the atmospheric pressure chemical ionization source is provided with a high-voltage discharge needle for releasing charges;
The cavity comprises a top and a bottom, the top and the bottom are opposite, the regulating device is arranged on the top, and the ionization region is positioned above the bottom;
The bottom comprises a flat plate and two inclined plates, wherein the inclined plates are respectively positioned at two sides of the flat plate, the cross sections of the flat plate and the inclined plates in the vertical direction are gradually recessed along the direction from the inclined plates to the flat plate, and the inclined plates are positioned above the flat plate;
the auxiliary heating device comprises a first heater and a second heater, the first heater is arranged at the bottom of the cavity, and the second heater is arranged on the ion source bracket;
The top is provided with a jack, the ion source support is hinged on the jack through an adjusting device, and the ion source support penetrates through the jack; the flat plate and the sloping plate are provided with mounting holes, the number of the first heaters is two, and the two first heaters are respectively matched with the mounting holes of the corresponding sloping plate;
the device also comprises a waste discharge device, wherein the waste discharge device is matched with the mounting hole of the flat plate;
in the directions of the cross sections of the flat plate and the inclined plate, the two first heaters are symmetrical with each other by taking a longitudinal central axis perpendicular to the flat plate as a symmetry axis;
the cavity also comprises a side plate, wherein an observation window is arranged on the side plate, and the observation window corresponds to the ionization region;
the ion source support is obliquely arranged on the top, the first heater is obliquely matched with the mounting hole, and the oblique direction of the second heater is consistent with the oblique direction of the ion source support;
The inclination direction of the ion source support is downward in an inclined mode in the vertical direction, the orientation direction of the first heater is upward in an inclined mode in the vertical direction, and the inclination directions of the ion source support and the first heater are both toward the ionization region.
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| CN114113292B (en) * | 2021-10-21 | 2023-06-16 | 广州质谱技术有限公司 | Atmospheric pressure chemical ionization source |
| CN115513038A (en) * | 2022-10-21 | 2022-12-23 | 中元汇吉生物技术股份有限公司 | A kind of ion source device and mass spectrometer |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109979797A (en) * | 2019-04-29 | 2019-07-05 | 昆山禾信质谱技术有限公司 | One kind being used for mass spectrometric ion source device and its application method |
| CN210040124U (en) * | 2019-07-25 | 2020-02-07 | 广州汇弘科技有限公司 | Compound mass spectrum ion source device |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5668370A (en) * | 1993-06-30 | 1997-09-16 | Hitachi, Ltd. | Automatic ionization mass spectrometer with a plurality of atmospheric ionization sources |
| US6646257B1 (en) * | 2002-09-18 | 2003-11-11 | Agilent Technologies, Inc. | Multimode ionization source |
| JP5359926B2 (en) * | 2010-02-23 | 2013-12-04 | 株式会社島津製作所 | Mass spectrometer |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109979797A (en) * | 2019-04-29 | 2019-07-05 | 昆山禾信质谱技术有限公司 | One kind being used for mass spectrometric ion source device and its application method |
| CN210040124U (en) * | 2019-07-25 | 2020-02-07 | 广州汇弘科技有限公司 | Compound mass spectrum ion source device |
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| CN110534396A (en) | 2019-12-03 |
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