CN110519986A - Stable formulations of water sensitive actives - Google Patents

Abstract

The present invention relates to a stable agrochemical granule composition comprising: at least one first agrochemical active ingredient, wherein the first agrochemical active comprises at least one of a water soluble active ingredient or a water sensitive active ingredient; at least one thermally stable plasticizer, wherein the plasticizer has a melting point greater than 20 ℃ and less than 150 ℃; at least one agrochemically acceptable excipient; wherein the particulate composition has a wettability of less than 20 minutes. The invention also relates to a process for preparing the stabilized agrochemical granule composition. The present invention also relates to a method of applying the stabilized agrochemical granule composition.

Description

Stable formulation of water sensitive actives

1. Field of invention:

The present invention relates to a stable granular composition comprising at least one agrochemical active ingredient, wherein the agrochemical active comprises a water-soluble active ingredient or water for agrochemical use. One or more of the sensitive active ingredients. More specifically, the present invention relates to a stable agrochemical granular composition comprising at least one agrochemical active ingredient, wherein the agrochemical active comprises a water soluble active ingredient or a water sensitive active at least one thermally stable plasticizer, wherein the plasticizer has a melting point greater than 20°C and less than 150°C; and at least one agrochemically acceptable excipient . The granular composition has a wettability of less than 20 minutes.

The present invention also relates to processes for preparing stable agrochemical granular compositions comprising one or more of a water-soluble active ingredient or a water-sensitive active ingredient. Furthermore, the present invention relates to methods of treating plants or soil with stabilized agrochemical granular compositions comprising water-soluble active ingredients or water-sensitive active ingredients.

2. Description of related fields:

In describing embodiments of the invention, specific terminology is chosen for the sake of clarity. It is not intended, however, that the invention be limited to the specific terms so selected, and it is to be understood that each specific term includes all technical equivalents that operate in a similar manner to accomplish a similar purpose.

Granular agrochemical compositions have become very popular in recent years because they are safer and easier to handle than conventional agrochemical formulations such as wettable powders and emulsifiable concentrates. Various agrochemical actives are known to be developed in the form of water-dispersible granule formulations due to the advantages offered by such formulations. Most granulation methods in use today, generally referred to herein as wet granulation, require the introduction of water for granulation, and then a drying step to remove the water.

Unfortunately, certain active agents have the disadvantage of being highly sensitive and unstable in aqueous media and easily degraded or modified under the influence of water due to poor chemical stability. Typically, hydrolysis is the most common water-mediated degradation mechanism; however, such actives may also undergo oxidation, dehalogenation, bond cleavage, Beckmann rearrangement, and other forms of degradation upon contact with water. Actives tend to lose their activity or convert to another form when in contact with water. Such actives typically lose their activity over time, and this instability is detrimental to desired field efficacy, rendering them unusable to the soil or plant or desired target. Furthermore, some agrochemical actives cannot be formulated into stable water-dispersible granule formulations due to their water-soluble nature.

To overcome these disadvantages, such active agents have been formulated in anhydrous liquid media. However, such formulations do not allow the incorporation of hydrophilic active agents. Furthermore, to avoid exposure to water, these actives have generally been known to be formulated as emulsifiable concentrates, dusts, wettable powders, and the like. However, these formulations contain a large amount of organic solvents, such as toluene, xylene, etc., resulting in the emission of thousands of tons of organic solvents in nature every year, posing serious risks and threats to the environment and soil in terms of toxicity and pollution. Furthermore, these compositions need to be applied at very high application doses.

In particular, in paddy fields, such agrochemical formulations presuppose uneven dispersion. In recent years, labor saving for dispersing (applying) agricultural chemicals and reducing agricultural chemicals has become important, and improvements in formulation forms of agricultural chemicals are required.

Furthermore, commercially available formulations tend to settle or settle on the bottom in one place, or float, disperse on the water surface, without providing good dispersion or disintegration of the active, which in turn fails to achieve the desired dispersibility and Even distribution of components to the crop for ingestion. Furthermore, such granule formulations have very poor hardness, leading to premature decomposition of these compositions during the production, storage, handling and application of these granules or powders, leading to substantial loss of release control, phytotoxicity problems and excessive nutrient leaching , which in turn reduces their efficacy in field applications. Accordingly, such compositions are applied at significantly higher dosages, thereby also increasing the cost of application for the farmer. Prior art compositions comprising water sensitive active ingredients or water soluble active ingredients provide compositions that do not have good wettability and disintegration time properties. These prior art compositions also tend to float for long durations, and also do not reach the root zone of the plant or the desired target area, and thus tend to leach out, resulting in inadequate pest control, loss to the farmer and damage to the plant. damage of environment.

Therefore, the preparation of stable anhydrous agrochemical granular formulations with water-soluble active ingredients or water-sensitive active ingredients is a major challenge. Therefore, there is a need for compositions with water-soluble active ingredients or water-sensitive active ingredients that can provide good stability of formulations under cold and warm conditions, showing good resistance of the active agent to oxidation or hydrolysis. Receptivity, exhibiting good firmness during storage or handling while providing improved crop protection from pest attack at reduced application rates over extended periods of time.

It has now surprisingly been found that stable agrochemical granule compositions with one or more water-soluble or water-sensitive active ingredients provide superior efficacy, ease of application, compared to conventional formulations, All properties of the active are maintained, decomposition of the active is avoided, and it is friendly to farmers and the environment. Interestingly, it has been found that stable anhydrous granular compositions having water soluble actives or water sensitive actives with at least one thermally stable plasticizer work effectively at reduced dosages to provide broader crop protection As well as the control of various insects, weeds, mites and fungi, improving the growth and quality of crops/plants, and thus being highly cost-effective in nature, which not only exhibits enhanced wettability, but also shows Improved hardness and good disintegration in water, thus ensuring uniform application and usability over an extended period of time.

Summary of the invention

The present invention relates to stabilized agrochemical granular compositions having: at least one or more agrochemical active ingredients, wherein the agrochemical active comprises one or more water soluble actives ingredient or water-sensitive active ingredient; at least one thermally stable plasticizer having a melting point greater than 20°C and less than 150°C; and at least one agrochemically acceptable excipient; wherein The granular composition exhibits a wettability of less than 20 minutes.

The present invention also relates to a process for the preparation of stable granular compositions involving mixing and blending at least one agrochemical active ingredient selected from the group consisting of one or more of a water soluble active ingredient or a water sensitive active ingredient; heating and cooling the mixture to obtain a stable agrochemical granular composition; wherein the granular composition exhibits wettability for less than 20 minutes.

The present invention also relates to a method of protecting crops or improving their health or yield by treating at least one of plants, crops, plant propagation material, seeds, seedlings or surrounding soil with a stabilized granular composition; said stabilized granular composition The article has at least one agrochemical active ingredient selected from one or more of a water-soluble active ingredient or a water-sensitive active ingredient; at least one heat-stable plasticizer; and at least one agrochemically acceptable excipient; wherein the granular composition exhibits wettability for less than 20 minutes.

It has been surprisingly observed that the composition not only exhibits a wettability of less than 20 minutes, but also has a hardness of less than 5N, demonstrating reduced breakdown of the active, good physical properties of disintegration, dispersion and suspension, and beneficial to the overall Good release properties for the crop life cycle. Furthermore, the composition exhibits surprisingly higher field efficacy at significantly lower applied doses of the composition.

Description of the invention

In describing embodiments of the invention, specific terminology is resorted to for the sake of clarity. It is not intended, however, that the invention be limited to the specific terms so selected, and it is to be understood that each specific term includes all technical equivalents that operate in a similar manner to accomplish a similar purpose.

The present invention relates to stable agrochemical granular compositions comprising: at least one agrochemical active ingredient. The agrochemical active ingredients include one or more of water soluble active ingredients or water sensitive active ingredients. The composition also comprises at least one thermally stable plasticizer having a melting point greater than 20°C and less than 150°C; and at least one agrochemically acceptable excipient. The granular composition exhibits a wettability of less than 20 minutes.

According to the invention, the term "water-sensitive active ingredient" means a chemically and/or physically unstable active agent. The term "chemical instability" means especially the degradation of the active principle. Water-sensitive agrochemical active ingredients are those ingredients that undergo water-mediated degradation such as hydrolysis, oxidation, dehalogenation, bond cleavage, Beckmann rearrangement, and other forms of degradation when exposed to water.

As used herein, the term "degradation" means the loss of activity of a water-sensitive active ingredient upon contact with water. Degradation can be determined simply by measuring the amount of active ingredient present before and after contact with water.

The term "physical instability" means especially crystallization or precipitation of the active agent, or a change in its color in the composition.

The term "water soluble active ingredient" is an agrochemical active ingredient that is soluble in water to a small or even a large extent. According to an embodiment, the agrochemical active ingredient has a solubility in water of greater than 0.1 mg/liter at 20°C. According to an embodiment, the agrochemical active ingredient has a solubility in water of greater than 0.5 mg/liter at 20°C. According to an embodiment, the agrochemical active ingredient has a solubility in water of greater than 1 mg/liter at 20°C. According to an embodiment, the agrochemical active ingredient has a solubility in water of greater than 1 g/liter at 20°C.

According to an embodiment, the agrochemical active is at least one selected from the group consisting of antifoulants, attractants, insecticides, fungicides, herbicides, nematicides, pheromones, defoliants, acaricides Agents, plant growth regulators, algicides, antifeedants, avicides, bactericides, bird repellents, biological insecticides, biocides, chemical sterilants, safeners, insect attractants, insect repellents , Insect Growth Regulator, Mammal Repellent, Mating Destroyer, Desiccant, Disinfectant, Molluscicide, Antimicrobial, Acaricide, Ovicide, Fumigant, Plant Activator, Rodenticide, Synergist agents, viricides, repellants, microbial insecticides, plant-incorporated protectants, other miscellaneous pesticide actives, or salts, derivatives and mixtures thereof.

According to the embodiment, the first agrochemical active substance or the second agrochemical active substance is at least one selected from but not limited to one or more of the following: abamectin, aminomethyl abamectin, Abscisic acid, ACC, acetophos, acequinocyl, acetamiprid, acethion, acetochlor, acetofenate, acetophos, acetoprole , acibenzolar, acifluorfen, aclofen, acetonitrile, acrep, bifenthrin, acrolein, acrylonitrile, acynonapyr, acypetacs, afidopyropen, afoxolaner, alachlor , naphthalene, aldicarb, albendazole, aldicarb, aldicarb sulfone, aldimorph, aldoxycarb, chlormethrin, allethrin, d-transallethrin, allicin , grass chlorpyrifos, alomycin, dioxam, allyl alcohol, dixacarb, alorac, α-bromadiolone, α-cypermethrin, α-endosulfan, cis-cypermethrin (alphamethrin), hexamethylmelamine, Aluminum phosphide, aluminum phosphide, pyraclostrobin, ametridione, ametryn, ametryne, ambuzin, Amifentrazone, amicarthiazol, amidithion, amidochlor, amidoflumet, sulfuron-methyl, methoxazone, chlorpromacil, chlorammonia Pyridinic acid, 4-aminopyridine, aminotriazole, amiprofos-methyl, amiprofos-methyl, amiprophos-methyl, indoxasulfame, amiprofos-methyl, bimethazine Amidine, Herbicide, Ammonium Sulfamate, Amobam, Amorphous Silica Gel, Amorphous Silica, Aminopropyl Phosphate, AMS, Promethaline, Cypromethanol, Antibacterial Aphrodisiac, sapylphos, anisuron, anthraquinone, antu, apholate, acetap, arprocarb, arsenic trioxide, thiram, aspirin, sulphon, moxa Athidathion, atrazine, atrazine, aureomycin, avermectin B1, AVG, aviglycine, penconazole, azadirachtin, azafenidin, pyridinphos, aphidicide Azidithion, rimsulfuron-methyl, azinphos-ethyl, azinphosethyl, azinphos-methyl, azinphos-methyl smethyl), aziprotryn, aziprotryne, thiram oxide, azobenzene, triazoltin, azothoate, azoxystrobin, bachmedesh, avenatine (barban), barbanate, barium hexafluorosilicate, barium polysulfide, barium fluorosilicate, pyrethrin, basic copper carbonate, basic copper chloride, basic copper sulfate, BCPC, fluorobutane Amamide, benalaxyl, benalaxyl-M, benalaxyl, bencarbazone, benclothiaz, bendaqingbingzhi, bentacarb, di Bendioxide, benefin, benfluralin, carbosulfan, furafosin, macaridin, benomyl, bemoxazor, benoxafos, chlorpyrifos Hydrazone, bensulfuron-methyl, difenfos, insecticide, bentaluron, thiazopyr, bentazone, benthiazil, thiathiocyanate, dicarbam, benclofen, amino acid Kill, benzalkonium chloride, benzamacril, benzamizole, benzamorf, benzene hexachloride, bisflumetrione, benzimine, benzachlor, benzobicyclo Ketones, endosulfan (benzoepin), metazazone, benzofluor, benzohydroxamic acid, benzmate, benzophosphate, benzothiadiazole, benzovindiflupyr , Benzoximate, Xinyanling, benzpyrimoxan, thiauron, benzyl adenine, benzyl benzoate, berberine, β-cyfluthrin, β-cypermethrin, bethoxazin, BHC, γ-BHC, bifenylphosphine, bicyclopyrone, bifenazate, carboxyfen, bifenthrin, κ-bifenthrin, bifenafosine (bilanafos), Le Acaricide, bingqingxiao, bio-allethrin, S-bio-allethrin, bioethrin, bio-permethrin, bio-resmethrin, biphenyl, bisazir, thiacumazole , Thiacumazole-copper, bisphenylmercury methylenedi (x-naphthalene-y-sulphonate) , bispyribac, bistrififluben, insecticide Bisultap, bisbenzotriazole, thiochlorophene, bixafen, blasticidin, borax, Bordeaux mixture, boric acid, pyryram, BPCMS, BP PS, brassinolide, ethyl brassinolide, bark beetle sex pheromone, brodifacoum, brofenprox, broflanilide, broflanilide, bromide Bifluthrin, diquam, bromadiolone, alpha-bromadiolone, dibromophos, bromethalin, bromethrin, bromfenvinfos, bromoacetamide, bran Bromobonil, bromobutyramide, bromociclen, bromophenacil, bromo-DDT, acetap, bromofos, methyl bromide, bromophos, Bromophos-ethyl, bromofen, bromothalonil, bromoxynil, bromoxychlor, bromocloconazole, bronopol, BRP, BTH, bucarpolate, synthetic Shacarb, buminafos, pyrimethrin, buprofezin, burgundy mixture, busulfan, busulphan, animal insects, Butachlor, fluprofen-methyl, butam, imafos, butane-fipronil, butathiofos, butachlor, butene-fipronil, permethrin Butethrin, Buthidazole, Buthidazole, Buthiuron, Butifos, Butanonecarb, Butylphos, Butopyronoxyl, Butansulfonecarb, Butyl, Leaf Rust special (butrizol), butazone, propargyl, butylamine, butachlor, butylchlorophos (butylchlorophos), butene-fipronil, cacodylic acid, sulfaphos, mefentrachlor, Calciferol, calcium arsenate, calcium chlorate, calcium cyanamide, calcium cyanide, calcium polysulfide, calvinphos, cambendichlor, toxaphene, camphor, d- Camphor, captafol, captan, carbam, morphancarb, chlormecarb, carbaril, carbaryl, carbasulam, carbathion, and more Carbendazim (carbendazim), carbendazol (carbendazol), bisamide, carbothion, carbufen, calcium disulfide, carbon tetrachloride, carbonyl sulfide, trithion, carbophos, carbosulfur Carboxazole, carboxazole, carbonyls, carboxazole, carboxazone, cyproamid, cartap, cartap hydrochloride, carvacrol, carvone, CAVP, CDAA, CDEA, CDEC, cypronil ( cellocidin), CEPC, ceralure, triclozone, cevadilla, cheshunt mixture, chinalphos, chinaphos-méthyl, chinomethionate, chiralaxyl, Chitosan, chlobenthiazone, methoxypyramid, chloralose, metropin, chloraminephosphorus, chloramphenicol, diamine, tetrachloro-p-benzoquinone, butyramid , chlorantraniliprole, chlorazifop, colazine, chlorbenside, chlorbenzuron, chlorbicyclen, chlorbromuron, chlorbufam , chlordane, chlordecone, chlordimeform, chlorempenthrin, chloretazate, chlorethephon, chlorethoxyfos, Chloreturon, chlorfenac, chlorfenapyr, chlorfenazole, chlorfenetol, chlorfenidim, chlorfenprop, chlorfenapyr Chlorfenson, chlorfensulphide, chlorfenvinphos, chlorfenvinphos-methyl, chlorfluazuron, chlorflurazole, chlorflurecol, Chlorfluren, chlorflurenol, chloridazon, chlorimuron, chlorinate, chlormephos, chlormequat , chlormesulone, chlormethoxynil, chlornidine, chlornitrofen, chloroacetic acid, chlorobenzilate, chlorodinitronaphthalene ), chl orofénizon, chloroform, α-chlorohydrin, chloromebuform, chloromethhiuron, chlorooneb, chlorophacinone, chlorophos, chlorophthalim, Chloropicrin, chloropon, chloroprallethrin, chloropropylate, chlorothalonil, chlorotoluron, chloroxifenidim, subtilon ( Chloroxuron, Chloroxynil, Chlorphonium, Chlorphoxim, Chlorphthalim, Chlorprazophos, Chlorprocarb , chlorpropham, chlorpyrifos, chlorpyrifos-methyl, chlorquinox, chlorsulfuron, chlorthal, chlorthiamid , chlorthiophos, chlortoluron, chlozolinate, cholecalciferol, choline chloride, chromafenozide, cicloheximide, Cimectacarb, cimetacarb, cinerin I, cinerin II, cinerin, cinidon-ethyl, cinmethylin , cinosulfuron, cintofen, ciobutide, cisanilide, cismethrin, clacyfos, cyclobenzazol Clefoxydim, clenpirin, clenpyrin, clethodim, climbazole, cliodinate, clodinafop, Cloethocarb, androcidal acid (clofencet), clofenotane, clofentezine, clofenvinfos, clofibric acid, clofop, clomazone, clomeprop ), clonitralid, cloprop, cloproxydim, clopyralid, cloquintocet, cloransulam, cyanamide Closantel, Clothianidin, Clotrimazole, Cloxyfonac, Cloxylacon, Clozylacon, CMA, CMMP, CMP, CMU, Dodecyl codlelure, colecalciferol, colophonate, copper acetate, copper acetoarsenite, copper arsenate, basic copper carbonate, copper hydroxide, copper naphthenate (copper naphthenate), copper oleate, copper oxychloride, copper 8-quinolinolate, copper silicate, copper sulfate, basic copper sulfate, copper zinc chromate ( copper zinc chromate), coumachlor, coumafène, coumafos, coumafuryl, coumaphos, coumatetralyl, caramel Coumethoxystrobin, coumithoate, coumoxystrobin, 4-CPA, 4-CPB, CPMC, CPMF, 4-CPP, CPPC, credazine, cresol , cresyl acid, crimidine, crotamiton, crotoxyfos, crotoxyphos, crufomate, cryolite, lycine (cue-lure), cufraneb, cumyleron, cumyluron, cuprobam, cuprous oxi de), curcumenol, CVMP, cyanamide, cyanatryn, cyanazine, cyanofenphos, cyanogen, cyanophos, fruit Cyanthoate, cyantraniliprole, cyanuric acid, cyazofamid, cybutryne, cyclafuramid, cypropamide ( cyclanilide), cyclaniliprole, cyclethrin, cycloate, cycloheximide, cycloprate, cycloprothrin, cyclo Cyclopyrimorate, cyclosulfamuron, cyclooxydim, cycluron, cyenopyrafen, cyflufenamid, cyflufenamid (cyflumetofen), cyfluthrin, beta-cyfluthrin, cyhalodiamide, cyhalofop, cyhalothrin, gamma-cyhalothrin, lambda - Cyhalothrin, cyhexatin, cymiazole, cymoxanil, cyometrinil, cypendazole, cypermethrin, α- Cypermethrin, β-cypermethrin, θ-cypermethrin, ζ-cypermethrin, cyperquat, cyphenothrin, cyprazine, cyprazole, cyproconazole ), cyprodinil, cyprofuram, cypromid, cyprosulfamide, cyromazine, cythioate, dodine ( cytrex), 1,3-D, 2,4-D, 3,4-DA, daimuron, dalapon, daminozide, dazomet, 2,4 -DB, 3,4-DB, DBCP , d-camphor (d-camphor), DCB, DCIP, DCPA (USA), DCPA (Japan), DCPTA, DCU, DDD, DDPP, DDT, ppTPAJa, DDVP, 2,4-DEB, debacarb , decafentin, deltamethrin, decarbofuran, DEET, dehydroacetic acid, deiquat, butachlor (delachlor), delnav, deltamethrin, demephion, demeton-O, demeton-S, demeton, demeton-methyl , Demeton-O, Demeton-O-methyl, Demeton-S, Demeton-S-methyl, Demeton-S-methyl demeton-S-methylsulphon, demeton-S-methyl sulphone, DEP, 2,4-DEP, depalléthrine, derris, 2, 4-DES, beet security (desmedipham), diquat (desmetryn), diquat (desmetryne), d-trans-proparthrin (d-fanshiluquebingjuzhi), diafenthiuron (diafenthiuron), phosphorus chloride ( dialifor), dialifos, di-allate, diallate, diamidophos, dianat, diatomaceous earth, diatomite ), diazinon, dibrom, 1,2-dibromoethane, dibutyl phthalate, dibutyl succinate, dicamba, dicapthon , dichlobenil, dichlobentiazox, dichlofenthion, dichlofluanid, dichlorone, dichloralurea, dichlorbenzuron, diuron ( dichlorfenidim), dichlorflurecol, dichlorflurenol, dichlo rmate), dichlormid, o-dichlorobenzene, ortho-dichlorobenzene, p-dichlorobenzene, para-dichlorobenzene ), 1,2-dichloroethane, dichloromethane, dichlorophen, 3,6-dichloropicolinic acid, 1,2-dichloropropane, 1,3-dichloropropene, 2,4-dipropane dichlorprop, dichlorprop-P, dichlorvos, dichlozoline, dichlorozoline, diclobutrazol, dichlorocyandiamide diclocymet, diclofop, diclomezine, dicloran, dicloromezotiaz, diclosulam, dicofol, dicophane, diclofenac Dicou-marol, dicresyl, dicrotophos, dicryl, dicumarol, dicyclanil, dicyclonon, dieldrin, Dienochlor, dietham-quat, acethachlor, diethion, diéthion, diethofencarb, synergistic phosphorus ( Dietholate, diéthon, diethylpyrocarbonate, di-ethyltoluamide, difenacoum, difenoconazole, dipropenazole ( difenopenten, difenoxuron, difenzoquat, difethialone, diflovidazin, diflubenzuron, diflufenican, diflufenican (diflufenicanil), diflufenzopyr, diflumetorim, dikegulac, dilor, dimatif, dimefluthrin, difluphos mefox), dimefuron, dimehypo, dimepiperate, dimetachlone, dimetan, dimethacarb, dimethachlone ), Dimethachlor, Dimethyn, Dimethenamid, Dimethenamid-P, Dimethipin, Dimethirimol, Le Dimethoate, Dimethomorph, Dimethrin, Dimethyl Carbate, Dimethyl Disulfide, Dimethyl Phthalate, Dimethylvinphos , Dimetilan, Dimexano, Dimidazon, Dimoxystrobin, Dimetilate, Dimuron, Difenol ( dinex), diniconazole, diniconazole-M, R-diniconazole, dinitramine, dinitrophenol, dinobuton , dinocap, dinocap-4, dinocap-6, dinocton, dinofenate, dinopenton, dinoprop, pentylnitrate Dinosam, dinoseb, dinosulfon, dinotefuran, dinoterb, dinoterbon, diofenolan, vegetable and fruit phosphorus ( dioxabenzofos, dioxacarb, dioxathion, dioxation, diphacin, diphacinone, diphenadione, diphenhydrazide (diphenamid), diphenamide, diphenylamine, diphenyl sulfone, diphenylsulphide, diprogulic acid, dipropalin, dibasin ( dipropetryn), trichlorfon (dipte rex), dipymetitrone, dipyrithione, diquat, disosultap, disparlure, disugran, disul, disulfiram ( Disulfiram), Disulfoton, Ditalimfos, Dithianon, Dithicrofos, Dithioether, Dithiométon, Fluorosulfur dithiopyr, diuron, dixanthogen, d-limonene, DMDS, DMPA, DNOC, dodemorph, dodicin , dodine, dofenapyn, doguadine, dominicalure, doramectin, 2,4-DP, 3,4-DP, DPC, hydrazine Drazoxolon, DSMA, d-trans-allethrin, d-trans-resmethrin, dufulin, sapuron ( dymron), EBEP, EBP, ebufos, α-ecdysone, β-ecdysterone, ecdysterone, echlomezol, EDB, EDC, EDDP, enemy edifenphos, eglinazine, emamectin, EMPC, empenthrin, enadenine, endosulfan, α-endosulfan, Endothal, endothall, endothion, endrin, enestroburin, enilconazole, enoxastrobin , ephirsulfonate, EPN, epocholeone, epofenonane, epoxiconazole, eprinomectin, epronaz, ε-trimethoprim epsilon-metofluthrin, epsilon-momfluoroth rin, EPTC, erbon, ergocalciferol, esdépalléthrine, esfenvalerate, ESP, esprocarb, etacelasil , Etaconazole, Etaphos, Etem, Ethaboxam, Ethachlor, Ethalfluralin, Ethamesulfuron, Methachlor (ethaprochlor), ethephon, ethidimuron, ethiofencarb, ethiolate, ethion, ethiozin, ethiprole (ethiprole), ethirimol, ethoate-methyl, ethobenzanid, ethofumesate, etohexadiol, ethoprop, Ethoprophos, ethoxyfen, (3-ethoxypropyl)mercuric bromide, ethoxyquin, ethoxysulfuron, ethychlozate , ethylan, ethyl-DDD, ethylene, dibromoethane, ethylene dichloride, ethylene oxide, ethyl formate, ethylicin, ethylmercury acetate, ethylmercury bromide (ethylmercury bromide), ethylmercury chloride, ethylmercury 2,3-dihydroxypropyl mercaptide, ethylmercury phosphate, N-( Ethylmercury)-p-toluenesulfonanilide, N-(ethylmercury)-p-toluenesulfonanilide, ethyl pyrophosphate, etinofen, ETM, etnipromid, etobenzanid ), etofenprox, etoxazole, etridiazole, etrimfos, étrimphos, eugenol, EXD, oxazole Ketone (famoxadone), amisulfon (fa mphur), fenac, fenamidone, fenaminosulf, fenaminstrobin, fenamiphos, fenapanil, pyrimidol (fenarimol), fenasulam, fenazaflor, fenazaquin, fenbuconazole, fenbutatinoxide, fenchlorazole, phosphophosphorus (fenchlorphos), fenclofos, fenclorim, fenethacarb, fenfluthrin, fenfuram, fenhexamid, Fenidin, fenitropan, fenitrothion, fénizon, fenjuntong, fenobucarb, fenolovo, 2,4,5-Fenoprop, fenothiocarb, fenoxacrim, fenoxanil, fenoxaprop, fenoxaprop-ethyl (fenoxaprop-P), fenoxasulfone, fenoxycarb, fenpiclonil, fenpicoxamid, fenpirithrin, fenpropathrin, fenpropidin , fenpropimorph, fenpyrazamine, fenpyroximate, fenquinotrione, fenridazon, fenson, fensulfothion, fen Fenteracol, Fenthiaprop, Fenthion, Fenthion-ethyl, Fentiaprop, Fentin, Tetrazole Fentrazamide, fentrifanil, fenuron, feuron-TCA, fenvalerate, ferbam, hydrazone (fe rimzone), ferric phosphate, ferrous sulfate, fipronil, flamprop, flamprop-M, flazasulfuron, flocoumafen, flometoquin, fluoride Flonicamid, florasulam, florpyrauxifen, fluacrypyrim, fluazaindolizine, fluazifop, fluorine fluazifop-P, fluazinam, fluazolate, fluazuron, flubendiamide, flubenzimine, bromfluthrin ( flubrocythrinate, flucarbazone, flucetosulfuron, fluchloralin, flucofuron, flucycloxuron, flucythrinate, fludiox Fludioxonil, fluénéethyl, fluenetil, fluensulfone, flufenacet, flufenerim, flufenican, Flufenoxuron, flufenoxystrobin, flufenprox, flufenpyr, flufenzine, flufiprole, fluhexafon, fluoride Fluindapyr, flumethrin, flumetover, flumetralin, flumetsulam, flumezin, acylidene Flumiclorac, flumioxazin, flumipropyn, flumorph, fluometuron, fluopicolide, fluopyril Fluopyram), Fluorbenside, Fluoridamid, Fluoroacetamide, Fluoroacetic Acid, Fluoxazone ( fluorochloridone), fluorodifen, fluoroglycofen, fluoroimide, fluoromide, fluoromidine, fluorofen ( Fluoronitrofen), Fluoroxypyr, Fluothiuron, Fluotrimazole, Fluoxastrobin, Flupoxam, Flupropacil , Flupropadine, Flupropanate, Flupyradifurone, Flupyrsulfuron, Fluquinconazole, Fluralaner, Jiecao Flurazole, flurecol, flurenol, fluridone, flurochloridone, fluromidine, fluroxypyr, furan Flurprimidol, flursulamid, flurtamone, flusilazole, flusulfamide, flutenzine, fluthiacet, fluthiazide Fluthiamide, flutianil, flutolanil, flutriafol, fluvalinate, tau-fluvalinate, fluxametamide, fluorine Fluxapyroxad, Fluxofenim, Folpel, Folpet, Fomesafen, Fonofos, Foramsulfuron, Forchlorfenuron ( forchlorfenuron), formaldehyde, formetanate, formothion, formparanate, fosamine, fosetyl, fosmethilan, fospirin Fospirate, fosthiazate, fosthietan, fron talin, fthalide, fuberidazole, fucaojing, fucaomi, fujunmanzhi, fulumi, and rodent ( fumarin), funaihecaoling, fuphenthiourea, furalane, furalaxyl, furamethrin, furamet ( furametpyr, furantebufenozide, furathiocarb, furcarbanil, furconazole, furconazole-cis, furethrin , furfural, furilazole, furmecyclox, furophanate, furyloxyfen, γ-BHC, γ-cyhalothrin, γ- HCH, genit, gibberellic acid, gibberellin A3, gibberellins, gliftor, glitor, glucochloralose, glufosinate Glufosinate, glufosinate-P, glyodin, glyoxime, glyphosate, glyphosine, sex attractant for pink bollworm gossyplure, grandlure, griseofulvin, guanoctine, guazatine, halacrinate, halauxifen ), halffenprox, halofenozide, halosafen, halosulfuron, haloxydine, haloxyfop, Haloxyfop-P, Haloxyfop-R, HCA, HCB, HCH, γ-HCH, hemel, hempa, HEOD, heptachlor, heptafluthrin , heptenophos, heptopargi l), herbimycin, herbimycin A, heterophos, hexachlor, hexachloran, hexachloroacetone, hexachlorobenzene, hexachlorobutadiene, hexachlorobutadiene, Chlorophenes, hexaconazole, hexaflumuron, hexafluoramin, hexafluorate, hexalure, hexamide, hexazinone, hexaphos (hexylthiofos), hexythiazox, HHDN, holosulf, homobrassinolide, huancaiwo, huanchongjing, huangcaoling, huanjunzuo , hydramethylnon, hydrargaphen, slaked lime, cyanamide, hydrogen cyanide, hydroprene, S-methoprene, hydroxyisoxazole, 4-hydroxy Phenylethyl alcohol, 8-hydroxyquinoline sulfate, hymexazol, hyquincarb, IAA, IBA, IBP, icaridin, imazalil , imazamethabenz, imazamox, imazapic, imazapyr, imazaquin, imazethapyr, imazosulfuron (imazosulfuron), imibenconazole, imicyafos, imidacloprid, imidaclothiz, iminoctadine, imiprothrin, inabenfide ), indanofan, indaziflam, indoxacarb, inezin, infusorial earth, iodobonil, iodine Iodocarb, iodofenphos, iodomethane, iodosulfuron, iofensulfuron, ioxynil, ipazine, IPBC, I PC, ipconazole, ipfencarbazone, ipfentrifluconazole, iprobenfos, iprodione, iprovalicarb , iprymidam, ipsdienol, ipsenol, IPSP, IPX, isamidofos, isazofos, isobenzan ), isocarbamide, isocarbamide, isocarbophos, isocil, isodrin, isofenphos, methalaphos, isofetamid, isoflucypram, isolan, isomethiozin, isonoruron, isopamphos, isopolinate, isoprocarb, Isoprocil, isopropalin, isopropazol, isoprothiolane, isoproturon, isopyrazam, isopyrimol ), isothioate, isotianil, isouron, isovaledione, isoxaben, isoxachlortole, bis Isoxadifen, isoxaflutole, isoxapyrifop, isoxathion, isuron, ivermectin, ixoxaben, Seed soaking phosphorus (izopamfos), soaking phosphorus (izopamphos), japonilure, japothrins, jasmolin I, jasmolin II, jasmonic acid, jiahuangchongzong , jiajizengxiaolin, jiaxiangjunzhi, jiecaowan, jiecaoxi, Jinganmycin A (Jinganmyci n A), iodothion (jodfenphos), juvenile hormone I, juvenile hormone II, juvenile hormone III, kadethrin, kappa-bifenthrin, kappa-septafluoro Kappa-tefluthrin, karbutilate, karetazan, kasugamycin, kejunlin, kelevan, ketospiradox , kieselguhr, kinetin, kinoprene, S-kinoprene, kiralaxyl, kresoxim-methyl, kuicaoxi ), lactofen, lambda-cyhalothrin, lancotrione, latilure, lead arsenate, lenacil, lepimectin , leptophos, lianbenjingzhi, lime sulfur, d-limonene, lindane, lineatin , linuron, lirimfos, litlure, looplure, lufenuron, cyantraniliprole, lüxiancaolin ), Chloroprexate (lvdingjunzhi), Chlorflufenthrin (lvfumijvzhi), chloroxyphosphine (lvxiancaolin), lythidathion (lythidathion), M-74, M-81, MAA, magnesium phosphide, Mala Malathion, maldison, maleic hydrazide, malonoben, maltodextrin, MAMA, mancopper, mancozeb ), mandestrobin, mandipropa-mid, maneb, matrine, mazidox, MCC, MCP, 1-MCP, MCPA, 2,4-MCPA, MCPA-thioethyl ester, MCPB, 2,4-MCPB, MCPP, o-amide (mebenil) , Mecarbam, mecarbinzid, mecarphon, 2-methyl-4-chloropropionic acid (mecoprop), refined 2-methyl-4-chloropropionic acid (mecoprop-P ), medimeform, medinoterb, medlure, mefenacet, mefenoxam, mefenpyr, chlorofluoroether Mefentrifluconazole, mefluidide, megatomoic acid, melissyl alcohol, melitoxin, MEMC, menazon, MEP, pyrimidine Mepanipyrim, meperfluthrin, mephenate, mephosfolan, mepiquat, mepronil, meptyldinocap, mercaptodimethur ), mercaptophos, mercaptophos thiol, mercaptothion, mercuric chloride, mercuric oxide, mercurous chloride, merphos, phosphite oxide , mesoprazine, mesosulfuron, mesotrione, mesulfen, mesulfenfos, mesulphen, mesoform Phenol, metaflumizone, metalaxyl, metalaxyl-M, R-metalaxyl, metalaldehyde, metam, oxazole Metamifop, metamitron, metaphos, metaxon, metazachlor, metazosulfuron, chloradrenone (metazoxolon), metcamifen, metconazole, metepa, metflurazon, methabenzthiazuron, methacrifos, methalpropalin , metham, methamidophos (meth amidophos), methasulfocarb, methazole, methfuroxam, methibenzuron, methidathion, methiobencarb, methionine Methiocarb, Methiopyrisulfuron, Methiotepa, Methiozolin, Methiuron, Methocrotophos, Metholcarb ), Metometon, Methomyl, Methoprene, S-Methoprene, Methoprotryn, Methoprotryne, Butylquinacrine ( methoquin-butyl), methothrin, methoxychlor, 2-methoxyethylmercuric chloride, methoxyfenozide, methoxyphenone, methyl Methyl apholate, methyl bromide, methyleugenol, methyl iodide, methamidophos, methyl isothiocyanate, methyl parathion, methyl ethyl phosphate ( methylacetophos), methylchloroform, 1-methylcyclopropene, methyldithiocarbamate, methyldymron, dichloromethane, methylmer-captophos, formazan Methylmercaptophos oxide, Methylmercury thiol, Methylmercury benzoate, Methylmercury dicyandiamide, Methylmercurypentachlorophenoxide, Methylneodecanamide (methylneodecanamide), methylnitrophos, methyltriazothion, metiozolin, metiram, metiram-zinc, metobenzuron , Metobromuron, Metofluthrin, ε-Metofluthrin, Iso Metolachlor, S-propachlor, metolcarb, metometuron, metominostrobin, metosulam, metoxadiazone , metoxuron, metrafenone, metriam, metribuzin, metrifonate, metriphonate, metsulfovax ), metsulfuron, mevinphos, mexacarbate, miechuwei, mieshuan, miewenjuzhi, acaridin ( milbemectin), milbemycin oxime, milneb, mimanan, mipafox, MIPC, mirex, MNAF, moguchun ), molinate, molosultap, monalide, heptanamide, momfluorothrin, epsilon-momfluorothrin, monisuron, monoamitraz, Monochloroacetic acid, monocrotophos, monolinuron, monomehypo, monosulfiram, monosulfuron, monosultap, imauron (monuron), imauron-TCA, morfamquat, moroxydine, morphothion, morzid, moxidectin, MPMC, MSMA, MTMC, α-multistriatin , muscalure, myclobutanil, myclozolin, myricylalcohol, NAA, NAAm, nabam, naftalofos, dibromophos (naled), naphthalene, naphthaleneacetamide, α-naphthaleneacetic acid, naphthalene dicarboxylic anhydride, naphthalophos, 1-naphthol, naphthoxyacid etic acid), naphthaleneacetic acid, naphthylindane-1,3-diones (naphthylindane-1,3-diones), naphthyloxyacetic acid, naproanilide, napropamide, napropamide- M, naptalam, natamycin, NBPOS, neburea, neburon, nendrin, neonicotine, nichlorfos, niclofen, niclosamide, nicobifen, nicosulfuron, nicotine, nicotine sulfate, nifluridide, nikkomycin , NIP, nipyraclofen, nipyralofen, nitenpyram, nithiazine, nitralin, nitrapyrin , nitrilacarb, nitrofen, nitrofluorfen, nitrostyrene, nitrothal-isopropyl, nobormide, nonanol, rattrane (norbormide), norea, nor-flurazon, nornicotine, noruron, novaluron, noviflumuron, NPA, Nuarimol, nuranone, OCH, octachlorodipropyl ether, octhilinone, 2-(octylthio)ethanol, o-dichlorobenzene, ofurace ), omethoate, orbencarb, orfralure, orthobencarb, orthodichlorobenzene, orthosulfamuron, oryctalure, orysastrobin , oryzalin, osthol, osthole, ostramone, ovatron, ovex, oxabetrinil, oxadiargyl, oxadiargyl Oxadiazon, oxadixyl, oxamate, oxamyl (oxamyl), oxapyrazon, oxapyrazone, oxasulfuron, oxathiapiprolin, oxaziclomefone, oxine- copper), quinoline-Cu, oxolinic acid, oxpoconazole, oxycarboxin, oxydemeton-methyl, oxydeprofos, sulfone Phosphorus (oxydisulfoton), oxyenadenine, oxyfluorfen, oxymatrine, oxytetracycline, oxythioquinox, PAC, paclobutrazol , paichongding, palléthrine, PAP, p-dichlorobenzene, parafluron, paraquat, parathion, parathion-methyl methyl), parinol, copper acetyl arsenite (Paris green), PCNB, PCP, PCP-Na, p-dichlorobenzene, PDJ, pebulate, pédinex, rice pefurazoate, pelargonic acid, penconazole, pencycuron, pendimethalin, penfenate, penflufen ), penfluron, penoxalin, penoxsulam, pentachlorophenol, pentachlorophenyl laurate, pentanochlor, penthiopyrad ( penthiopyrad), pentmethrin, pentoxazone, perchlordecone, perfluidone, permethrin, pethoxamid, PHC, phenamacril, ethyl cyanstrobin, phénaminosulf, phenazine oxide, phénétacarbe, phenisopham, phenthion nkapton), phenmedipham, ethyl betaining, phenobenzuron, phenothiol, phenothrin, phenproxide, phenthoate, 8-phenylmercurioxyquinoline, phenylmercuriurea, phenylmercuric acetate, phenylmercuric, phenylmercuric derivatives of catechol, phenylmercuric nitrate, phenylmercuric salicylate , 2-phenylphenol, phorate, phosacetim, phosalone, phosametine, phosazetim, phosazetin, Phoscyclotin, phosdiphen, phosethyl, phosfolan, methylthiocyclophos, phos-glycin, phosmet ), phosnichlor, phosphoramide, phosphamide, phosphine, phosphinothricin, phosphocarb, phosphorus, phostin, phoxim ( phoxim), methyl phoxim, phthalide, phthalophos, phthathrin, picarbutrazox, picaridin, picloram, pyrfluben Picolinafen, picoxystrobin, pimaricin, pindone, pinoxaden, piperalin, piperazine, butanoate (piperonyl butoxide), piperonyl cyclohexenone (piperonyl cyclonene), piperophos, piproctanly, piproctanyl, piprotal, pirimetaphos ), pirimicarb, piriminil, pirimioxyphos, pirimiphos-ethyl, pirimiphos-methyl, pivaloyl indanedione (pival), pivaldione, Triclosinate (plifenate), PMA, PMP, polybutene, polyurethane , polychlorcamphene, polyethoxyquinoline, polyoxin D, polyoxin, polyoxorim, polythialan, potassium arsenite, Potassium azide, potassium cyanate, potassium ethyl xanthate, potassium naphthenate, potassium polysulfide, potassium thiocyanate, pp'-DDT, prallethrin, precocene I , precolin II, precocious protein III, pretilachlor, primidophos, primisulfuron, probenazole, prochloraz, proclonol ), procyazine, procymidone, prodiamine, profenofos, profluazol, profluralin, profluralin Profluthrin, profoxydim, profurite-aminium, proglinazine, prohexadione, prohydrojasmon, fendicarb (promacyl), promecarb, prometon, prometryn, prometryne, promurit, pronamide, propachlor , propafos, propamidine, propamocarb, propanil, propaphos, propaquizafop, propargite, formazan Proparthrin, propazine, propetamphos, propham, propiconazole, propidine, propineb, propisochlor, propoxur, propoxycarbazone, propyl isome, propyrisulfuron, propyzamide, propoxyquin Proquinazid, prosulactone, prosulfalin, prosulfocarb, prosulfuron, prothidathion, prothiocarb, prothioconazole, prothion (prothiofos), prothoate, protrifenbute, proxan, prymidophos, prynachlor, psoralen, psoralene, pydanon, pydiflumetofen, pyflubumide, pymetrozine, pyracarbolid, pyraclofos, pyraclonil, pyraclostrobin, pyraflufen , fipronil (pyrafluprole), pyrimidinewei (pyramat), pyramethostrobin (pyrametostrobin), pyraoxystrobin (pyraoxystrobin), sulfonyl pyrazole (pyrasulfotole), pyrazole pyrimidine (pyraziflumid), pyrazolate (pyrazolate) ), pyrazolynate, pyrazon, pyrazophos, pyrazosulfuron, pyrazothion, pyrazoxyfen, pyresmethrin ), pyrethrin I, pyrethrin II, pyrethrins, pyribenz-isopropyl, pyribenz-propyl, pyribencarb, saflufenacil ( pyribenzoxim), pyributicarb, pyriclor, pyridaben, pyridafol, pyridalyl, pyridaphenthion, pyridazine Pyridaphenthione, pyridate, pyridinitril, pyrifenox, pyrifluquinazon, pyriftalid, pyrimétaphos , pyrimethanil, pyrimethanil ((pyrimicarbe), pyrimidifen, pyriminobac, pyriminostrobin, pyrimiphos-éethyl, pyrimiphos-méethyl, pyrimisulfan, pyrimitate, pyrinuron, pyriofenone, pyriprole, pyripropanol, pyriproxyfen, pyrisoxazole, pyrithiobac ), pyroxacarb (pyrolan), pyroquilon, pyroxasulfone, pyroxsulam, pyroxychlor, qincaosuan, qingkuling ), quassia, quinacetol, quinalphos, methyl quinathion, quinazamid, quinclorac, quinconazole, quinoxalic acid ( quinmerac), quinoclamine, quinofumelin, quinomethionate, quinonamid, quinothion, quinoxyfen, quintiofos, Quintozene, Quizalofop, Quizalofop-P, Quwenzhi, Quyingding, Rabenzazole, Rafoxet (rafoxanide), R-diniconazole, rebemide, reglone, renofluthrin, renriduron, rescalure, resmethrin, D-trans resmethrin, thiocyanate (rhodethanil), rhodojaponin-III, ribavirin, rimsulfuron, rizazole, R-metalaxyl ), thiocyanate (rodéthanil), ronnel, rotenone, ryan ia), sabadilla, saflufenacil, saijunmao, saisentong, salicylanilide, salifluofen, sanguinarine (sanguinarine), santonin, sarolaner, S-bioallethrin, schradan, scilliroside, sebutylazine, micaotong ( secbumeton), sedaxane, selamectin, semiamitraz, sesamex, sesamolin, sesone, sethoxydim ), carbaryl (sevin), S-methoprene (S-hydroprene), shuangjiaancaolin, shuangjianancaolin, siduron, perfluthrin (sifumijvzhi), siglure, silafluofen, silatrane, silica aerogel, silica gel, silthiofam, silthiofam ( silthiopham), silthiophan, silvex, simazine, simeconazole, simeton, simetryn, simethyn ( simetryne), androsin (sintofen), S-methoprene (S-kinoprene), slaked lime (slaked lime), SMA, S-methoprene (S-methoprene), S-propachlor (S- metolachlor), sodium arsenite, sodium azide, sodium chlorate, sodium cyanide, sodium fluoride, sodium fluoroacetate, sodium hexafluorosilicate, sodium naphthenate, sodium o-phenylphenate, sodium pentachlorophenolate , sodium pentachlorophenolate, sodium o-phenylphenate, sodium polysulfide, sodium fluorosilicate, disodium tetraborate, sodium tetrathiocarbonate, sodium thiocyanate, solan, sophamide , spinetoram, spinosad, spirodiclofen, spiromesifen, spirotetramat, spiroxamine, Stirofos, streptomycin, strychnine, sulcatol, sulcofuron, sulcotrione, sulfallate ), sulfentrazone, sulfiram, sulfluramid, sulfodiazole, sulfometuron, sulfosate, sulfosulfuron, moth control Phosphorus (sulfotep), sulfotepp, sulfoxaflor, sulfoxide, sulfoxime (thioxime ether), sulfur, sulfuric acid, sulfuryl fluoride, sulglycapin, sulfosulfur Sulphosate, sulprofos, sultropen, swep, 2,4,5-T, tau-fluvalinate, barnipene (tavron), tazimcarb, 2,4,5-TB, 2,3,6-TBA, TBTO, TBZ, TCA, TCBA, TCMTB, TCNB, TDE, tebuconazole, wormamide Tebufenozide, Tebufenpyrad, Tebufloquin, Tebupirimfos, Tebutam, Tebuthiuron, Tecloftalam, Tecnazene, Tecoram , tedion, teflubenzuron, tefluthrin, kappa-tefluthrin, tefuryltrione, tembotrione , temefos, temephos, tepa, TEPP, tepraloxydim, teproloxydim, terallethrin, special Terbacil, terbucarb, terbuchlor, terbufos, terbumeton, terbutylazine, terbutol, terbutryn, terbutryn (terbutryne), terraclor, terramicin, terramycin, tetcyclacis, tetrachloroethane, tetrachlorvinphos, tetraconazole, triclosan Tetradifon, tetradisul, tetrafluron, tetramethrin, tetramethylfluthrin, tetramine, tetranactin, cyanamide Tetraniliprole, tetrafluoropropionate, tetrasul, thallium sulfate, thallous sulfate, thenylchlor, theta-cypermethrin ), thiabendazole, thiacloprid, thiadiazine, thiadifluor, thiamethoxam, thiameturon, thiapronil , thiazafluron, thiazfluron, thiazone, thiazopyr, thicrofos, thicyofen, thiazimin ), thidiazuron, thiencarbazone, thifensulfuron, thifluzamide, thimerosal, thimet, thiobencarb, Thiocarboxime, thiochlorfenphim, thiochlorphenphime, thiocyanatodinitrobenzene, thiocyclam, thiodan, thiabylcopper ( thiodiazole-copper), thiodicarb, thiofanocarb, thiofanox, thiofluoximate, thiohempa, thiomersal, methyl ethyl Phosphorus (thiometon), thiometon (thiometon) onazin), thiophanate, thiophanate ethyl, thiophanate methyl, thiophos, thioquinox, thiosemicarbazide, thiosultap, Thiotepa, thioxamyl, thiram, thiuram, thuringiensin, tiabendazole, tiadinil, Fenner (tiafenacil, tiaojiean, TIBA, tifatol, tiocarbazil, tioclorim, tioxazafen, tioxymid, TMTD, tirpate, tolclofos-methyl, tolfenpyrad, tolprocarb, tolpyralate, tolyfluanid, tolylfluanid, tolylmercury acetate), tomarin, topramezone, toxaphene, 2,4,5-TP, 2,3,3-TPA, TPN, tralkoxydim , deltacythrin (tralocythrin), tetramethrin (tralomethrin), bromopyrrole nitrile (tralopyril), D-trans allethrin, D-trans resmethrin, transfluthrin (transfluthrin), trans Transpermethrin, tretamine, tri-allate, triacontanol, triadimefon, triadimenol, flucarbazone (triafamone), triallate, triamiphos, triapenthenol, triarathene, triarimol, triasulfuron, thiazocarb ( triazamate, triazbutil, triaziflam, triazophos, triazothion, triazoxide, tribasic copper chloride, tribasic sulfuric acid copper, Tribusulfuron, tribufos, tributyltin oxide, tricamba, trichlamide, triclopyr, trichlorfon , Trichlormetaphos-3, Trichloronat, Trichloronate, Trichlorotrinitrobenzene, Trichlorphon, Triclopyr, Chloridine Triclopyricarb, tricresol, tricyclazole, tricyclohexyl tin hydroxide, tridemorph, tridiphane, trietazine, snail morpholine ( trifenmorph), trifenofos, trifloxystrobin, trifluxysulfuron, trifludimoxazin, triflumezopyrim, triflumizole ), triflumuron, trifluralin, flusulfuron, trifop, trifopsime, triforine, trihydroxytriazine, 2,3 , 5-tri-iodobenzoic acid, 2,3,5-tri-iodobenzoic acid, trimedlure, trimethacarb, trimeturon, trinexapac, three Phenyltin, triprene, tripropindan, triptolide, tritac, trithialan, triticonazole, trifluoro Tritosulfuron, trunc-call, tuoyelin, uniconazole, uniconazole-P, urbacide, uredepa, Valerate, validamycin, validamycin A, valifenalate, valone, vamidothion, vangard, vaniliprole, imbab ( vernolate), vinclozolin (vin clozolin), vitamin D3, warfarin, xiaochongliulin, xinjunan, xiwojunan, xiwojunzhi, XMC, xylenechlor (xylachlor), xylenols, xylylcarb, xymiazole, yishijing, zarilamid, zeatin, zengxiaoan , zengxiaolin, zeta-cypermethrin, zinc naphthenate, zinc phosphide, zinc thiazole, zinc thiazole, zinc trichlorophenate, trichloro Zinc trichlorophenoxide, zineb, ziram, zolaprofos, zoocoumarin, zoxamide, zuoanjunzhi, Methazone (zuocaoan), pyraclostrobin (zuojunzhi), oxazone-methyl (zuomihuanglong), 1-MCP, 1-methylcyclopropene, 1-naphthol, 1,2-dichloropropane, 1,3- D, 1,3-dichloropropane, 2iP, 2-methoxyethylmercuric chloride, 2-(octylthio)ethanol, 2-phenylphenol, 2,3,3-TPA, 2,3 ,5-triiodobenzoic acid, 2,3,6-TBA, 2,4-D, 2,4-DB, 2,4-DEB, 2,4-DEP, 2,4-DES, 2,4- DP, 2,4-MCPA, 2,4-MCPB, 2,4,5-T, 2,4,5-TB, 2,4,5-TP, (3-ethoxypropyl)mercuric bromide , 3,4-DA, 3,4-DB, 3,4-DP, 3,6-dichloropicolinic acid, 4-aminopyridine, 4-CPA, 4-CPB, 4-CPP, 4-hydroxyphenethyl alcohol , 8-hydroxyquinoline sulfate, 8-phenylmercuryoxyquinoline, or salts, derivatives and mixtures thereof.

According to an embodiment, the first agrochemical active ingredient is a water sensitive active ingredient. According to embodiments, water-sensitive actives include, but are not limited to, one or more of the following: clodinafop-propargyl, acetamiprid, pinoxaden, tetrazolin Azimsulfuron, bensulfuron, chlorimuron, chlorsulfuron, ethersulfuron, cyprosulfuron, ethametsulfuron, ethoxysulfuron, pyrimuron-methyl, flupyrsulfuron, halosulfuron, imazosulfuron, iodosulfuron, methylsulfuron-methyl, metsulfuron-methyl, nicosulfuron-methyl, flumesulfuron-methyl, fluprosulfuron-methyl , pyrasulfuron-methyl, rimsulfuron-methyl, rimsulfuron-methyl, sulfsulfuron-methyl, thiasulfuron-methyl, trisulfuron-methyl, tribenuron-methyl, flusulfuron-methyl, trifloxysulfuron-methyl, trifluoromethylsulfuron-methyl, solution Cloquintocet-mexyl, thiamethoxam, mesotrione, cartap, cartap hydrochloride, acephate, acifluorfen, trifluorocarboxylate Acifluorfen-sodium, aldicarb, aminocarb, aminopyralid, asulam sodium, azamethiphos, bromoxynil ( bromoxynil), chloropicrin, trimethoprim, dicamba, flufenpyrazone, dimethenachlor, dimethenamid, bispyribac-sodium (bispyribac-sodium), high-efficiency dimethenamid, dimethenoate, dinotefuran, DNOC, dodine, indophos, ethephon, ethiprole, ethylene bisisothiocyanate sulphide, cyprofen, fosetyl-aluminium, thiazophos , glufosinate-ammonium, biguanide octyl salt, imazamethabenz-methyl, imazamox, imazethapyr, imazethapyr, imazaquin, imazethapyr, Ioxynil, butylamidine amide, MCPA, MCPB, 2-methyl-4-chloropropionic acid, metalaxyl, chlormetrione, metam-sodium, methamidophos, mecitrione, long-term Phytophos, oxacarb, rimsulfuron-methyl, oxymuron, picloram-dimethylammonium (picloram-dimethylammonium), picloram-trolamine (picloram-trolamine), pirimicarb, propensulfuron - sodium (propoxycarbazone-sodium), pufencao, pyrithiobac-sodium (pyrithiobac-sodium), pyroquiloquinone (pyroquilo ne), Methsulam, quinclorac-dimethylammonium (quinclorac-dimethylammonium), quinoxalic acid, algaquinone, pyrimidine sulfamide, sethoxydim, sulfuron-methyl, tembotrione, terbuthylazine , thiasulfuron-methyl, thiafluzamide, thiocyclam hydrogen oxalate, thiocyclam, monoclocarb, oxentrazone, tribenuron-methyl, trichlorfon , triclopyr, uniconazole, fipronil and their salts or derivatives.

According to an embodiment, the first agrochemical active ingredient is a water soluble active. According to embodiments, water-soluble actives include, but are not limited to, one or more of the following: acephate, acetamiprid, acethion, acetic acid, acetochlor, acetochlor (acetoprole), S-methyl activated ester (acibenzolar-S-methyl), acifluorfen, acifluorfen sodium, aclonifen (aclonifen), acrolein, acrylonitrile, aciclopyrene ( afidopyropen), alachlor, alanycarb, aldicarb, aldimorph, aldoxycarb, allidochlor, alloxydim, allyl alcohol, pest control Carboxyl (allyxycarb), alorac, α-chloroethanol, α-endosulfan, α-hexachlorocyclohexane, α-naphthalenethiourea, ammonium aluminum sulfate, aluminum phosphide, aluminum silicate, ametoctradin , ametridione, ametrazine, ambuzin, amicarbazone, amidithion, metolachlor, amidosulfuron, fruit Phosphorus (amidothioate), methoxur, aminocyclopyrachlor, aminopyralid, amitrafos-methyl, amisulbrom, amiton, amitraz ), amitrole, ammonium acetate, ammonium carbonate, ammonium hydroxide, ammonium sulfamate, ammonium sulfate, ammonium thiocyanate, ampropylfos, ancymidol, enemy bacteria Anilazine, Anilofos, Souron, ANTU, Aramite, Arsenic trioxide, Asomate, Sodium Sulfate, Asulam, Ethidasone, Atraton, atrazine, azaconazole, fendin, pyridinate, rimsulfuron-methyl, azinphos-ethyl, azinphos-methyl , azide, azithiram oxide, azobenzene, azophosphorus, azobenzene oxide, azoxystrobin, oat spirit, barium carbonate, barium polysulfide, beflubutamid , benalaxyl, high-efficiency benalaxyl, benazolin ethyl, benazolin, bencarbazone, benclothiaz, bendiocarb, benfuracarb, benazolin nfuresate), benodanil, benomyl, benquinox, tribenuron-methyl, tolusulfuron-methyl, bensulide, bensultap, benzene Bentaluron, bentazone, benthiavalicarb-isopropyl, benthiazil, benzadox-ammonium, benzadox-ammonium, benzalkonium chloride, benzamacril isobutyl, benzamacril, benzamorf, benzfendizone, benzipram, benzofenap, fensulfonamide benzofluor, benzoic acid, benzovinfluconazole, benzoylprop, benzoylprop, benzoylprop, benzthiazuron, benzthiazuron, benzyl benzoate, beta-cypermethrin, benzoylprop Bethoxazin, flumetrazone, bifenazate, bifenox, binapacryl, bio allethrin, biopermethrin, biobenzfur Bioresmethrin, biphenyl, bis(2-chloroethyl) ether, bis(methylmercury) sulfate, bispyribac-sodium, bisthiosemi, bistrichloromethyl sulfone, bisphenyltriazole Bitertanol, bithionol, bixafen, bone oil, Bordeaux mixture, boric acid, boscalid, brassinolide, bromothrin ( brofluthrinate, bromacil, bromadiolone, bromfenate, bromobonil, bromobutide, bromocyclen, bromofenoxim , methyl bromide, bromthion, ethyl bromathion, bromopropylate, bromoxynil, brompyrazon, bromuconazole, bromuron, bronopol, hexacarb (bufencarb), fenclofen, bupirimate, buprofezin, butachlor, butafenacil, butamifos, Butanethiol, butathiofos, butenachlor, buthiazolone, buthiobate, buthiuron, butocarboxim, butonate , Deetone, butoxycarboxim, butralin, butroxydim, buturon, butylate, cacodylic acid , cadusafos, cafenstrole, calcidol, calcium acid methanesulfonate, calcium arsenate, calcium carbide, calcium carbonate, calcium chloride, calcium cyanamide ), calcium hydroxide, calcium phosphate, calcium phosphide, cambendichlor, camphechlor, captafol, captan, carbamorph, chlorine Carbanolate, carbaryl, carbasulam, carbendazim, carbetamide, carbofuran, carbon dioxide, carbon disulfide, carbon tetrachloride, phosphorus trithion ( carbophenothion), carbosulfan, carboxazole, carfenazol-sulfoxide, carfentrazone-ethyl, carpropamid, carfenicide Dan, cartap hydrochloride, chinomethionat, chlobenthiazone, chloromethoxyfen, chloralose, chloramben, chloraniformethan, Chloranil, chloranocryl, chlorantraniliprole, chlorazifop propargyl, chlorazifop, chlorazifop, chlorazifop, borneol, chlorobromone , Chloracopyl, Chlordane, Chlordecone, Chlordimeform, Yuxiongsha, Phosphorus Oxychloride, Chloreturon, Vazor, Chlorfenapyr, Chlorfenazole, Fofol , Methyl avenate, Fabate, Difenpyr, Toxapam, Chlorfluazole, Chlorfluren methy l), Chlorfluren, Methyl Chlorazadin, Chlorazadin, Chlorazin, Ethyl Chlorsulfuron-methyl, Chlormethylphos, Chlormequat Chloride, Phytoquat, Ethyl fofol, Itomin, Boron, Dimasan, Chloropicrin, Chloropicrin, Trichloropropionic acid, Propyl fofol, Chlorothalonil, Chlorotoluron, Subtilon, Chlorodimethyl Phenol, chlorpyrifos, chlorpyrifos, chlorpyrifos, chlorpyrifos, tetrachloroquinoxaline, chlorsulfuron, Chlortetracycline, dimethadon, triclosan, chlorthion, chlorthion, chlorthion, choline chloride, chromafenozide, cycloheptafen, etesulfuron , cyanobenamide (ciobutide), trimeuron, cis-permethrin, clethodim, mitrazone, iodochloridinate (cliodinate, clodinafop, clodinafop-propargyl, cetricarb, androszin acid, clofop, clomazone, clomazone, cloproxydim, cloproxydim, clopicralin monoethanolamine, clopicralin, methyl Sulfalamide, Clothianid, Clothianidin, Glycolic Acid, Cuprous Oxide(1), Copper Acetyl Arsenite, Copper Bis(3-Phenylsalicylate), Copper Acetate II, Chloride Copper II, Copper Hydroxide II, Copper Oxychloride, Copper Sulphate, COS-OGA, Warfarin Chloride, Kefafarin, Meclostrobin, Metystrobin, Phosphorus, Syringstrobin, Pyridaclofen, Ratsil, crotamiton, simethon, thiaril, benzuron, thiram copper chloride, cyanamide, cyanazurin, cyanazine, cypronil, nectarphos, cyantraniliprole (cyantraniliprole), Cyazofamid, Cybutryne, Cyclopropamide, Cyclaniliprole, Cyclothrin, Cyclobad, Cycloheximide, Cyclopyrimorate, Cypromethrin cyhalofop-butyl, cyhalofop-butyl, cyhalofop-butyl, tricyclic tin, acarid, cymoxanil, cyanide Bactendazim, benzalkine chloride, benzalkine, cyclazine, cyproconazole, cypromethazine, carboxylamine, cyclamide, cyprosulfonamide, cyromazine, dacetam, butyrhydrazide, Chalquat-sodium, palapaquat, DAEP, profencarb, decaphostin, defenuron, dehydroacetic acid, isobutachlor, telophos, telophos-O, telophos-S, demeton, formazan Isodemeton sulfone, Demeton methyl, Isodemeton methyl, Demeton methyl, Demeton methyl-S, benzyl ammonium benzoate amide, betaine, diquat, phosphorous chloride, oat enemy, Diamidaphos, diammonium ethylenebis (dithiocarbamate), diammonium hydrogen phosphate, diazinon, dibromochloropropane, dicamba, dichonil, demiphos, inhibitor Bactendazim, dichloronaphthoquinone, dichlorophen, 2,4-dipropionic acid, 2,4-dipropionic acid, dichlorvos, benzyl triaconazole, diclofenac, dichlorophen, Methylprop, Diclofenac, Nichloramine, Diclosulam, Dicofol, Dicrotophos, Dicyclopentene, Didodecyldimethylammonium Chloride, Oxychloromethylene Naphthalene , metolachlor ethyl, Difencarb, DEET, Ratac, difenoconazole, difenopenten ethyl, difenopenten, cumulon, avenate cumyl sulfate, avenate , Thiaclozoate, Flufenazine, Flupyrazohydrazone, Fluoximil, Difunon, Tufuric Acid, Tufuric Acid-Sodium, Mefluphos, Oxazolone, Dimethachlor, Dimethoxam Net, dimethenamid, high-efficiency dimethenamid, thimethene, pyrimol, dimethoate, dimethenamid, dimethyl disulfide, dimethyl (4-piperidine carbonyloxy-2, 5 -Methylbenzyl)sulfonium toluene-4-sulfonate, chlorpyramid-methyl, chlorpyrifos, dimidazon, xyloxystrobin, dimethicol, dinex-diclexine, alkene Diconazole, diniconazole-M, dichloramine, Xiaofentong, Xiaomaipu, Xiaofencarb, Dilet, Xiaomaiduo, Pentonitrophenol, Dicrophenol Acetate, Dimophen, Nitroxin Esters, dinotefuran, tylofen, phenoxyfen, dioxabenzophos, dioxacarb, dichlorphos, dimethazine, dibenzamide, diphenylamine, dilealine, dioxazone, dipyridine Thionium, diquat dibromide, diquat, disodium methanesulfonate (disodiummethanearsonate), disodium octaborate tetrahydrate (disodium octaborate tetrahydrate), disodium phosphonate, ditilate, disodium sodium (disul -sodium), sterilized phosphorus, dicyanoanthraquinone, dithiopyr, diuron, double xanthate, DNOC, dodecaline acetate, dodecaline, multifruit, dormant oil ( dormant oil), diazoxazolone, metafluon, difenfos, ethylglycyrrhizin, ethynethrin, endosulfan, endothrin, enoxastrobin, aldrin, enoxastrobin , epichlorohydrin, EPN, propionyl brassinolide, baobab, epoxiconazole, EPTC, Yizafon, pentazon, vinyl silicon, ecloconazole, etaphos, dyson Sulfur, ethaboxam, ethametsulfuron, ethametsulfuron, ethylamine, glyoxal, ethanethiol, ethephon, sulfonethiuron, ethylthiobencarb, ethion, ethametrione , ethiprole, pyrimethrimol, efurofazone, yiguo, fenfenphos, ethyl chlorofluorfen, chlorofluorfen, ethoxyquin, ethoxysulfuron, vinyl diisothiocyanate Sulphide, ethylene dichloride, ethylmercury bromide, nitrosol, tribendazim, pyrimion, imidazolidin, dexazone, fenoxastrobin, fenamiphos, imidaclonil, chlorobenzene Pyrimidinol, fenasulam (fenasulam), fenacazole, fenaxazole, carbenazole, ethylclofenazole, pisphos, penfluthrin, formazan Furanilide, fenhexamid, seed coat ester, fenitrothion, secbucarb, 2,4,5-nylpropionic acid, 2,4,5-nylpropionic acid butoxyethyl ester (fenoprop-butotyl ), fenthiocarb, cyanoxaprop-ethyl, fenoxaprop-ethyl, fenoxasulfone (fenoxasulfone), fenoxycarb, seed dressing, cypermethrin, fenprothrin Esters, fenpropidin, fenpropimorph, pyrafenone, fenquinotrione (fenquinotrione), pyridazinonic acid, fenfen, fonsofos, ethyl thiazoprop, thiazoprop, Fenthion, triphenyltin acetate, triphenyltin chloride, triphenyltin hydroxide, tetrazolamide, feuron, ferbam, iron phosphate, fipronil, wheat straw, high-efficiency wheat straw -Isopropyl, sulfuron-methyl, fludifafen, flonicamid, florasulam, pyrimidaben, fluroxypyr-butyl, fluroxypyr-butyl, fluazinam, fluroxymite Thiothiazide, flucarbazone sodium, flupisulfuron, flucarbazone, flucyvalerate, fludioxonil, biflumite, fluensulfone, flufenacet, flufenerin ), flufenapen, flupyridoxate ethyl, tetraprole, flufenapyr, flumiclorac-pentyl (flumiclorac-pentyl), flumechlor propargyl, propargyl, flumorph, Fluuron, Fluoxamid, Fluopyram, Fluoxal, Fluoracetamide, Acifluorfen, Fluoxyfen, Fenpyrid, Fluothiuron, Triflubenazole , fluoxastrobin, flufenoxazole, flupropacil, flupropadine hydrochloride, fluriatidine, sodium tetrafluoropropionate, flupyradifurone, flurizine flupyrsulfuron, fluroxypyrsulfuron sodium, fluquinazole, azadin, fluroxypyrone, fluroxypyrone, fluroxypyr, fluroxypyr-meptyl, fluroxypyr, furan Grassone, flusilazole, sulfazone, methoxazone, flutianil, flunamide, flufenazole, flufenapyramide, fluroxyxime, sterilin, fomesafen, and groundworm Phosphorus, foramsulfuron-methyl, forchlorfenuron, formaldehyde, acetamidine, ango, formparanate, woodphosphine, triethylphosphonic acid, aluminum triethylphosphonate, fenfos, fospyril , thiazophosphine, buthiophene, wheat suinging, furanfenozide (fufenozide), furfenthiourea, furaxyl, furaxyl-M, furamet, furantamcarb, furantazole, cis Fuconazole, furfural, fenoxazole, seed dressing amine, aflufen, glycofur, gliotoxin, glufosinate-ammonium, glufosinate-ammonium, glufosinate-ammonium, glutaraldehyde, pectin, glufosinate Glyphosate trimethyl sulfide, glyphosate, isopropylamine salt, glyphosate, glyphosate potassium, glyphosate, griseofulvin, biguanide octyl salt, quinoline acrylate, halauxifen methyl, fluchloropyridine Esters (halauxifen), chlorine Tebufenozide, flunitric acid sulfonamide, halosulfuron-methyl, halosulfuron-methyl, haloxyfop, haloxyfop-etyl, haloxyfop-ethyl, fluorine Pyroxyprop-methyl, heptafluthrin, heptamaloxyloglucan, heptenylphos, production-stimulating oxime, heterophos, hexachlorophene, hexaconazole, hexafluoride, hexazinone, hexaphos (hexylthiofos, hexythiazox, huanjunzuo, hydrogen peroxide, methoprene, hymexazol, quinocarb, icaridin, imazalil, imaza-methyl, imazaza-methyl , imazamox, imazethapyr, imazethapyr, imazaquin, imazethapyr, imazosulfuron, imidazole, imicyafos, imidacloprid, biguanide octyl triacetate, iminoctadine tris(albesilate), octylamine, imamethrin, tributazone, indenzazone, indaziflam, indoxacarb, benzapine, iodobonil, iodophos, iodomethane, iodine Sulfururon, iodosulfuron-methyl-sodium, iofensulfuron sodium, iofensulfuron, iodobenzonitrile lithium, iodosulfuron sodium, iodobenzonitrile sodium, Ioxynil, cloconazole, trifenazole, isopyridine, iprodione, iprocarbam, IPSP, ferric sulfate, isamidofos, flurafen, butamidine, water amine Thion, isogran, alanamiphos, anifos-methyl, isofetamid, isofetamid, ammazine, isapamuron, isopamphos, isopolinate, isoprocarb, Isopropraline, Inotropin, Isoproturon, Fenafenafil, Isopyrimol, Mephiphos, Isotianil, Isoxauron, Isoval, Clomazone, Isoclomazone , isoxaflutole, clomazone, soaking phosphorus, kaolin (kaolin), cardazolin, Kelevan (kelevan), methoprene, kresoxim-methyl, dipropen, cyclopyridine, p-bromo Phosphorus, lime sulfur, limestone, lindane, Liguron, perfluorooctane lithium perfluorooctane sulfonate, harmful phosphorus, magnesium phosphide, malathion, maleic hydrazide, cyanide, mancocopper, Mancozeb, mandestrobin, mandiprodil, maneb, azide, MCPA, MCPA-thioethyl ester, MCPB, m-cumylmethylcarbamate, ortho Amide, aphidphos, mecarbinzid, tetramethylphosphonate, 2-methyl-4-chloropropionic acid, refined 2-methyl-4-chloropropionic acid, medetomidine, dioxam Acetate, Delox, Benthiazamide, Fomesulam, Menadione, Mephidone, Azoxycycline, Diamidophos, mepiquat chloride, mepiquat, mepiquat, mepiquat, mercuric oxide, mercurous chloride, dephyllophos, methylsulfuron-methyl, methylsulfuron-methyl (mesosulfuron-methyl), mesotrione, mesulfenfos (mesulfenfos), metalaxyl, metalaxyl-ethyl, metaldehyde, mefenamide, promethenone, metamure-potassium , vebamur sodium, mezafen, metazosulfuron (metazosulfuron), metazoxolon (metazoxolon), metconazole, methyl diba, thiazolon, chrysanthemum fear, methamidophos, sulfonate Bacteriocarb, Promethazol, Furafenam, Methiopyrsulfon, Methiocarb, Methiopyrsulfuron, Methiopyrsulfuron, Methiozolin, Methiazolin, Methocrotophos ), methoprene, methoprene, methoxypropane, methoxychlor, methoxyfenozide, debumiazone, methyl isothiocyanate, methyl (((1-(5-(2- Chloro-4-(trifluoromethyl)phenoxy)-2-nitrophenyl)-2-methoxyethylidene)amino)oxy)acetate (fucaomi), methyl arsenic sulfide, formazan arsenic acid, methylsulfauron, methylenebisthiocyanate (methylenebisthiocyanate), disenlian, pyranuron, Xiugulong, metofluthrin, propachlor, amethocarb, Fenoxystrobin, sulfentrazone, methoxuron, metrafenone, mecitrione, metsulfovax, metsulfuron-methyl, metsulfuron-methyl, memethafos, Zikewei, fenamidophos, and Metamine, momfluorothrin, heptanamide, monocrotophos, chlorguron, monosodium methylarsonate (monosodium methylarsonate), monosulfuron-methyl, monosulfuron-methyl, mebab Chloron, Falquat Dichloride, Falquat, Thionfos, Mucochloric Anhydride, Myclobutanil, Triclozolin, N-(3-Chloro-2,6-Dimethylphenyl) -2-Methoxy-N-(tetrahydro-2-oxy-3-furyl)acetamide, Sodium dison, Phosphorus dibromide, Nanosilver pesticide, Naphthalene, Naphthalic anhydride , naproamide, napropamide, napropamide-M, naphthalene, oxabuturon, bis(dimethyldithiocarbamate) nickel, niclosamide, nicosulfuron, nitenpyram, Nithiazine, sulforaline, trichloromethylpyridine, nitrilacarb, fenpyroxyfen, phthastrobin, N-methylneodecanamide, N-nitrosodimethylamine, mouse Trane, Norflurazon, Protonicotine, Methron, Polyfluorourea, Fluoxetine, O, O-Dimethyl α-(2,4-Dichlorophenoxyethoxy) Ethyl phosphate, octhilone, mefuramide, oxygen Huamethoate, Bicaedan, Fyrisulfuron, Orysastrobin, Ansulphin, Oxapronil, Propylene-Oxadiazone, Oxadiazone, Oxafaxyl, Killiancarb, Methazone, oxapyrazon-dimolamine , Oxazone Sodium, Epoxysulfuron-methyl, Oxathiapiprolin, Oxazicone, Ossolinic Acid, Oxpoconazole Fumarate, Oxyprofen, Sulfonate , isosulfoxide phosphorus, sulfone mixed phosphorus, oxyfluorfen, paclobutrazol, paraffin oil (C11-C30) [4c], paraffin oil C15-C30) [4b], paraffin oil [3Not NEU], paraquat dichloride Compounds, paraquat, parathion, methyl parathion, methionine, penconazole, pendiclofen, pendimethalin, flufenapyridine, penoxsulam, pentachlorophenol, fenconazole , Penthiopyrad, Cycloxadiazone, Oryzaba, Permethrin, Peracetic Acid, Methochlor, Cotamine, Beetin, Daofengsan, Phenyl Mercuric Acetate, Benzene Nitrate Mercury (phenylmercury nitrate), phorate, tetramine, phosalon, phosametine, chlorpyrafos, thionate, thionate, imidophos, phosnichlor , phosphamide, phosphine, phoxim, tetrachlorophthalide, picarbutrazox, picloram, picloram-dimethylammonium, picloram-triethanolamine, picoxystrobin, rodentone, pinoxaden, Triclosan, diphenazofos, pizenazolin bromide, piperazolin, pirimicarb, pirimiphos-ethyl, pirimiphos-methyl, triclosinate, polybutene, potassium bicarbonate, potassium iodide, potassium phosphate , potassium thiocyanate, proparthrin, pretilachlor, flurisulfuron-methyl, flurisulfuron-methyl, prochloraz, procymidone, profenofos, flufentrazone, ciprofluran, propane Fluthrin, Cyclotrione, Ethyl Gampazine, Gampazine, Prohexadione, Calcium Prohexadione, Tickicarb, Mengshacarb, Prometon, Promethazine, Toxachlor, Propamocarb Hydrochloride , propamocarb, propanil, profenfos, oxaclo-methyl, clofenac, permetranet, aniline, propiconazole, zinc-methyl, propionic acid, propachlor, propoxur, propanesulfon Probensulfuron-methyl-sodium, propyrisulfuron, benzamide, propoxyquinoline, prothofen, fluprosulfuron-methyl, prothidathion, amiprocarb, prothioconazole, fago , cyprochlorin, proximpham (proximpham), propargyl chloramine, pymetrozine, pyraclofen, pyrazofos, pyraclocarb, pyraclostrobin, metazachlor, pyrimidinecarb, oxazolamide Strostrobin, pyraclostrobin, trifenfos, pyrasulfuron ethyl, pufencao, isopropyl fen, propyl fen, saflufenacil, pyridafenthion, pyridafol ), pyridafol-O-methyl (pyridafol-O-methyl), pyridafol, pyridoxine, pyrifluquinazon (pyrifluquinazon), pyridafen, Pyrimethanil, pyriminobac-methyl, pyriminostrobin, pyrimisulfan, pyriofenone, pyriproxyfen, pyridoxazole, pyriminobac-methyl, pyriminostrobin, sulfone Pyroxasulfone, Methosulam, QRD-460, Quartz sand, Quetiafos, quinclorac, quinclorac-dimethylammonium, quinoxalic acid, Algaquinone, Quinamide, Animal Ningphos (quinothion), quinafos, pentachloronitrobenzene, quizalofop-ethyl, quizalofop-ethyl, quizalofop-tefuryl (quizalofop-P-tefuryl), rimsulfuron-methyl, pyrimidinethio Amide, octamethylphosphine, other butylzine, micaton, sedaxane (sedaxane), sethoxydim, cyclofluron, silicon dioxide, thiosilicilamine, sodium thiosulfate, silver thiosulfate, Simazine, silfluazole, siclozine, androline, S-methoprene, S-propachlor, 5-nitroguaiacolate (sodium5-nitroguaiacolate), sodium aluminosilicate, Sodium arsenate, sodium carbonate, sodium chlorate, sodium chloride, bicarbonate, sodium hypochlorite, sodium o-nitrophenolate, sodium p-nitrophenolate, sodium tetraborate pentahydrate, spinosad, spirofen , spirotetramat, spirulina amine, toxaphene (strobane), sulcotrione, cloxazone, sulfentrazone, sulfluramid, methylsulfuron-methyl, sulfenylsulfuron-methyl, sulfosulfuron, Sulfamizone, sulfonyl fluoride, sulfur, sulfuric acid, thioprofos, TCA-sodium, tebuconazole, tebufenozide, tebufenpyrad, tebufloquin, pirimiphos-butyl, phosphatamine, Tethhiuron, Teclophthalein, Tetrachloronitrobenzene, Tefluthrin, Tefuryltrione, Tembotrione, Pyroxydone, Cyclopentalthrin, Tetradim, Tebutin Grass ammonium, terbufos, terbutazone, terbuthin, triflumezin, tetracyclazole, insecticide, tetrafluconazole, tetraethyl pyrophosphate, tetramethrin, perfluthrin, thiophene Methyl chloride, thiabendazole, thiacloprid, thiamethoxam, thiapropionil, thiaflon, thiazodine, thiabendonil, thiadiafenamide, thiencarbazone, thiencarbazone -methyl), thiasulfuron-methyl, thiasulfuron-methyl, thifluzamide, chlorpyramid, chormecarb, dimecycloxalate, diazocyclam, thiodicarb, monoclocarb, dithiocarb-methyl , thiophanate-methyl, thiophanate-methyl, thiosultap, thiosultap-disodium, thiosultap-monosodium, thiourea, thiram, thiazil, tiafenacil , Zhongcaodan, tioxazafen, tolclofos-methyl, tolylfluanid, tolylfluanid, oxazone, trimethylbenzotrione, deltacypermethrin, trans-permethrin, triadimefon, triadimenol , Mecamba, Carbafos, Imbadazole , benfenthiat, tribenuron-methyl, trimecarb, triazophos, pyraclostrobin, tribenuron-methyl, tribenuron-methyl, defoliate phosphorus, tributyltin oxide, salicylella Amines, trichlorfon, triclopyr, triclopyr-butotyl, triclopyr-triethylammonium, triclopyr, triclopyricarb, tricyclazole, Tridemorpholine, Promethazol, Trifenofos, Trifloxystrobin, Trifluxysulfuron, Trifluxysulfuron Sodium, Triflumezopyrim, Fluconazole, Trimetriuron, Triflumezopyrim Triflumezopyrim, fluconazole, trifluralin, triflusulfuron-methyl, triflusulfuron-methyl, triflusulfuron-methyl, triflusulfuron-methyl, triflumezopyrim, oxacarb, ethylclofenac Esters, paraformaldehyde, methoprene thioester, fendazole, trifluoromethylsulfuron, uniconazole, urea sulfate, urea, valifenalate, valinomycin, aphidol, synergyl ether (verbutin), mezabad, vinclozolin, warfarin, XMC, xylenechlor, methiocarb, zarilamid, zinc borate, zinc oxide, zinc zinc, thiram, benzoyl Bacteril or its salts or mixtures.

According to another embodiment, the agrochemical active is a pesticide active including, but not limited to, one or more of the classes of actives selected from the group consisting of neonicotinoid insecticides, oxy Phenoxylates, cyclohexanedione oxime herbicides, sulfonylurea and quinoxyacetic acid herbicide safeners, HPPD-inhibiting herbicides, phenylpyrazoles, nereistin analog insecticides and organophosphate insecticides agent.

According to an embodiment, the first agrochemical active ingredient is preferably selected from one or more of the following: Acequinocyl, acrolein, alachlor, molopyr, α-endosulfan, acequinone Granville, xylidine amidine, difenazol, pyridinate, azinphos-ethyl, oat spirit, carbofuran, benomyl, insecticide, bifenazate, methyl bromide, heptanoyl bromide ( bromoxynil heptanoate), bromoxynil octanoate, butansulfonecarb, captan, carbaryl, carbosulfan, pyrentrazone-ethyl, cartap, cartap hydrochloride , quitrafenone, indoxafen-methyl, clodinafop-propargyl, tetrafenazine, cyflumet-methyl, cymoxanil, dacemuron, beetan, bacteriostatic, dichlorvos, dicofol, dicyananthraquinone, and trifenfos , endosulfan, ethephon, ethylthiobencarb, oxaflumedone, oxacloxazone, enobucarb, triphenyltin acetate, ferbam, sulfuron-methyl, fluazinam, fluoride Oxalic acid-amyl, fluramid propargyl, fluroxyfen ethyl carboxy, fluridine sulfuron-methyl sodium, sterilizing mono, methamidine, Anguo, methyl chlorpyrazosulfuron, ethoxy flupyrrox Haloxyfop-etotyl, heptachlor, heptenyl, hydrazone, ioxynil octanoate, iprodione, isoxaflutole, malathion, mancozeb, Morin manganese, webam sodium, methamidophos, dysenlian, methamidophos, Zikewei, dibromophos, naphthachlor, trichloromethylpyridine, mefuramide, omethoate, oxamethoxam, Epoxysulfuron-methyl, oxidized carboxyl, beetin, phorate, chlorpyrafos, imidophos, phoxim, pinoxaden, fenidyl, zinc-methyl, pyrenza-ethyl Ether, pyridate, quizalofop-ethyl, quizalofop-tefuryl (quizalofop-P-tefuryl), rimsulfuron-methyl, spirotetramat, phosphonium, sulfonyl fluoride, tefuryl, tefuryl fenthion, tetraethyl pyrophosphate, dimecycloxal oxalate, dimecyclam, thiram, tolylfluanid, transfluthrin, zomicarb, tribenuron-methyl ), trichlorfon, triclopyr, triflusulfuron-methyl, valifenalate, valifenalate, vinclozolin, zinc, thiram, and benzamide.

According to another embodiment, the first agrochemical active ingredient is preferably selected from one or more of the following: Acequinocyl, acrolein, alachlor, xylidine amidine, avenatine, propionate Carbofuran, benomyl, insecticide, bifenazate, captan, carbosulfan, cartap, cartap hydrochloride, quintrazone, indoxafen, clodinafop-propargyl , tetrafenazine, cyflumetone, cymoxanil, damaron, beetan, dichlorvos, dicofol, dicyanoanthraquinone, ethephon, oxaflucone, triphenylacetate, ferbam, fluazinam, Fluoxalic acid-amyl, propargyl fluramid, sterilizing mono, methimidine, Anguo, ethoxypyroxyfop, heptachlor, iprodione, isoxaflutole, mancozeb, Maneb, Webam sodium, Methamidophos, Dysenlian, Zikewei, Dibromophos, Nafechlor, Mefuramide, Betainin, Phorate, Pinoxaden, Imophos, Zinc-methyl, pyridate, quizalofop-ethyl, sulfonyl fluoride, tetraethyl pyrophosphate, dimecycline, thiram, tolylfluanid, transfluthrin, thiramcarb , trichlorfon, pyrazine, vinclozolin and thiram.

According to another embodiment, the first agrochemical active ingredient is preferably selected from one or more of the following: alachlor, amitraz, chlorproparpyl, benomyl, sulphon, biphenyl Hydrazine ester, captan, carbosulfan, cartap, cartap hydrochloride, cyflufenate, dacemet, beetan, dicyanoanthraquinone, triphenyltin acetate, flucarbamate, propyl Flufenoxam, sterilizing mono, Anguo, Heptachlor, Isoxaflutole, Maneb, Dysenlian, Dibromophos, Mefuramide, Beetin, Imophos, Pinoxaden, Sulfuryl Fluoride, Tetraethyl Pyrophosphate, and Zirbane.

According to yet another embodiment, the agrochemical active substance may be any one of cartap, cartap hydrochloride, pinoxaden.

According to another embodiment, the second agrochemical active is fipronil.

According to an embodiment, the first agrochemical active or the second agrochemical active is present in a concentration range of at least 0.01% by weight of the total composition. According to an embodiment, the agrochemical active is present in a concentration range of at least 1% by weight of the total composition. According to an embodiment, the agrochemical active is present in a concentration range of at least 5% by weight of the total composition. According to an embodiment, the agrochemical active is present in a concentration range of at least 10% by weight of the total composition. According to an embodiment, the agrochemical active is present in a concentration range of at least 20% by weight of the total composition. According to an embodiment, the agrochemical active is present in a concentration range of at least 30% by weight of the total composition. According to an embodiment, the agrochemical active is present in a concentration range of at least 40% by weight of the total composition. According to an embodiment, the agrochemical active is present in a concentration range of at least 50% by weight of the total composition. According to an embodiment, the agrochemical active is present in a concentration range of at least 60% by weight of the total composition. According to an embodiment, the agrochemical active is present in a concentration range of at least 70% by weight of the total composition. According to an embodiment, the agrochemical active is present in a concentration range of at least 80% by weight of the total composition. According to an embodiment, the agrochemical active is present in a concentration range of at least 90% by weight of the total composition.

According to another embodiment, the agrochemical granules are selected from water dispersible granules, fine granules, micro granules, soluble granules, emulsifiable granules, dispersible granules, broadcast granules, disintegrable granules or extruded granules. According to yet another embodiment, the agrochemical granules are preferably large granules, disintegrable granules or extruded granules.

According to an embodiment, the particle composition comprises particles that are polygonal, spherical, elliptical, or any polyhedral particles without affecting the excellent properties observed. According to an embodiment, the agricultural particles are substantially spherical.

According to an embodiment, the particle composition is in the size range of 0.1 mm to 6 mm. According to another embodiment, the particle composition is in the size range of 0.1 mm to 3 mm. According to yet another embodiment, the particle composition is in the size range of 0.1 mm to 2 mm. According to still further embodiments, the particle composition is in the size range of 0.1 mm to 1 mm.

According to an embodiment, the particles formed have a particle size in the range of 0.1 microns to 100 microns. According to an embodiment, the particles formed have a particle size in the range of 0.1 microns to 60 microns. According to an embodiment, the particles formed have a particle size in the range of 0.1 microns to 30 microns. According to an embodiment, the particles formed have a particle size in the range of 0.1 microns to 20 microns.

According to another embodiment, the granule composition of the invention exhibits a reduced bulk density compared to known compositions, which facilitates faster disintegration of the granules and also prevents the composition from settling in water. The granular composition also exhibits improved hardness and wear resistance compared to known pellets or granules.

The granular composition surprisingly has good hardness. According to an embodiment, the hardness exhibited by the particulate composition is at least 1 Newton.

According to an embodiment, the particulate composition has a hardness of at least 3 Newtons. According to an embodiment, the particulate composition has a hardness of at least 5 Newtons. According to another embodiment, the particulate composition has a hardness of at least 10 Newtons. According to another embodiment, the particulate composition has a hardness of at least 20 Newtons. According to another embodiment, the particulate composition has a hardness of at least 30 Newtons.

According to another embodiment, the particulate composition has a hardness of at least 40 Newtons. According to another embodiment, the particulate composition has a hardness of at least 60 Newtons. The hardness exhibited by the particles is evaluated by a hardness tester such as those supplied by Shimadzu, Brinell Hardness (AKB-3000 model), Mecmesin, Agilent, Vinsyst, Ametek and Rockwell.

According to an embodiment, the granular composition has a disintegration time of less than 30 minutes. According to an embodiment, the granular composition has a disintegration time of less than 20 minutes. According to one embodiment, the granular composition has a disintegration time of less than 10 minutes. According to an embodiment, the granular composition has a disintegration time of less than 5 minutes. According to an embodiment, the granular composition has a disintegration time of less than 3 minutes. According to an embodiment, the granular composition has a disintegration time of less than 2 minutes. According to an embodiment, the granular composition has a disintegration time of less than 1 minute. According to an embodiment, the granular composition has a disintegration time of less than 30 seconds. The disintegration time was evaluated by disintegration test equipment such as those provided by Electrolab Edutec, Arentek and Shimadzu.

According to yet another embodiment, at least 99% of the granular composition disintegrates in less than 30 minutes. According to yet another embodiment, at least 50% of the granular composition disintegrates in less than 20 minutes. According to yet another embodiment, at least 30% of the granular composition disintegrates in less than 10 minutes. According to yet another embodiment, at least 20% of the granular composition disintegrates in less than 5 minutes. According to yet another embodiment, at least 10% of the granular composition disintegrates in less than 3 minutes. According to yet another embodiment, at least 5% of the granular composition disintegrates in less than 1 minute. According to still further embodiments, at least 2% of the granular composition disintegrates in less than 30 seconds.

According to an embodiment, the bulk density of the granular composition is less than 1.5 gms/ml. According to an embodiment, the bulk density of the granular composition is preferably less than 1.2 gms/ml. According to another embodiment, the bulk density of the granular composition is preferably less than 1.0 g/ml. According to another embodiment, the bulk density of the granular composition is preferably less than 0.9 g/ml.

According to another embodiment, the granular composition of the present invention exhibits improved floatability compared to known granules, which facilitates excellent availability of the composition to crops or plants, reducing leaching of actives. The composition exhibits reduced settling of the composition in water. The granular composition also exhibits improved disintegration, dispersion and suspension compared to known granules.

Floatability can be defined as the ability of a particulate composition to remain on the surface of a fluid without sinking. According to an embodiment, the floatability of the granular composition is less than 99%. According to another embodiment, the floatability of the granular composition is less than 90%. According to an embodiment, the floatability of the granular composition is less than 80%. According to an embodiment, the floatability of the granular composition is less than 70%. According to an embodiment, the floatability of the granular composition is less than 60%. According to an embodiment, the floatability of the particulate composition is less than 50%. According to an embodiment, the floatability of the granular composition is less than 40%. According to an embodiment, the floatability of the granular composition is less than 30%. According to embodiments, the agrochemical granular composition has a floatability of less than 25%. According to embodiments, the agrochemical granular composition has a floatability of less than 15%. According to embodiments, the agrochemical granular composition has a floatability of less than 10%. According to embodiments, the agrochemical granular composition has a floatability of less than 5%. According to an embodiment, the agrochemical granular composition has a floatability of less than 3%. According to embodiments, the agrochemical granular composition has a floatability of less than 1%. According to embodiments, the agrochemical granular composition has a floatability of less than 0.5%.

Abrasion resistance determines the resistance of a granular material to abrasion. The process for determining attrition resistance involves agitating the pellets by tumbling in a bucket to simulate a fluidized bed. After a period of time has elapsed, the material is sieved and weighed to determine the amount of material that has been reduced below a certain size (known as "fines"). According to an embodiment, the abrasion resistance of the particles is at least 30%. According to an embodiment, the abrasion resistance of the particles or pellets is at least 40%. According to an embodiment, the abrasion resistance exhibited by the particles is at least 50%. According to an embodiment, the abrasion resistance of the particles is at least 60%. According to an embodiment, the abrasion resistance of the particles is at least 70%. According to another embodiment, the particles exhibit at least 80% abrasion resistance. According to an embodiment, the particles exhibit at least 90% abrasion resistance. The details of the tests are defined by various standards as applicable for the purpose in question, such as those defined by ASTM, well known to those skilled in the art.

Dispersibility is defined as the ability of particles to disperse when added to a liquid such as water or a solvent. To determine the dispersibility of a granular composition according to standard CIPAC test MT 174, a known amount of the granular composition is added to a defined volume of water and mixed by stirring to form a suspension. After standing for a short period of time, the upper nine tenths were removed and the remaining tenth was dried and determined gravimetrically. This method is actually a shortened test of suspensibility and is suitable for determining the ease with which a particulate composition disperses uniformly in water. According to an embodiment, the granular composition has a dispersibility of at least 40%. According to an embodiment, the granular composition has a dispersibility of at least 50%. According to an embodiment, the granular composition has a dispersibility of at least 60%. According to an embodiment, the granular composition has a dispersibility of at least 70%. According to an embodiment, the granular composition has a dispersibility of at least 80%. According to an embodiment, the granular composition has a dispersibility of at least 90%.

Suspension is defined as the amount of active ingredient suspended in a liquid column of defined height after a given time, expressed as a percentage of the amount of active ingredient in the original suspension. In order to determine the suspendability of granular compositions (according to CIPAC MT-184), a suspension of a known concentration of granular compositions in CIPAC standard water is prepared and placed in a prescribed graduated cylinder at a constant temperature and allowed to remain unaffected. Interference lasts for a specified amount of time. The upper 9/10 is taken and the remaining 1/10 is then determined chemically, gravimetrically or by solvent extraction and the suspensibility is calculated.

According to an embodiment, the particulate composition has a suspendability of at least 10%. According to an embodiment, the particulate composition has a suspendability of at least 20%. According to an embodiment, the particulate composition has a suspendability of at least 30%. According to an embodiment, the particulate composition has a suspendability of at least 40%. According to an embodiment, the particulate composition has a suspendability of at least 50%.

According to an embodiment, the particulate composition has a suspendability of at least 60%.

According to an embodiment, the particulate composition has a suspendability of at least 70%.

Wettability is the condition or state of being wettable, and can be defined as the degree to which a solid is wetted by a liquid, as measured by the adhesive force between the solid and liquid phases. Wettability of granular compositions is measured using standard Cipac Test MT-53, which describes a procedure for determining the time to complete wetting of a wettable formulation. A weighed amount of the granular composition was dropped from a specified height onto the water in a beaker, and the time for complete wetting was determined. According to an embodiment, the granular composition has a wettability of less than 30 minutes. According to another embodiment, the granular composition has a wettability of less than 20 minutes. According to another embodiment, the granular composition has a wettability of less than 15 minutes. According to another embodiment, the granular composition has a wettability of less than 10 minutes. According to another embodiment, the granular composition has a wettability of less than 5 minutes. According to another embodiment, the granular composition has a wettability of less than 2 minutes. According to another embodiment, the granular composition has a wettability of less than 1 minute. According to another embodiment, the granular composition has a wettability of less than 30 seconds.

According to another embodiment, the agrochemical active is a solid active. According to further embodiments, the agrochemical active has a melting point greater than 35°C. According to further embodiments, the agrochemical active has a melting point greater than 40°C. According to further embodiments, the agrochemical active has a melting point greater than 45°C. According to further embodiments, the agrochemical active has a melting point greater than 50°C.

According to embodiments, the composition further comprises one or more of a fertilizer, a second pesticide active, a macronutrient and a micronutrient or a salt thereof.

According to another embodiment, the fertilizer includes, but is not limited to, one or more of the following: mononutrient fertilizers, multinutrient fertilizers, micronutrients, binary fertilizers, compound fertilizers, organic fertilizers, derivatives or mixtures thereof. Preferably, the fertilizer includes but not limited to at least one of nitrogen fertilizer, sulfur fertilizer, phosphorus fertilizer, potassium fertilizer or salts, derivatives and mixtures thereof. According to still other embodiments, nitrogen fertilizers may include urea, ammonium sulfate, ammonium nitrate, anhydrous ammonia, ammonium nitrate sulphate, diammonium phosphate, nitrogen solution, monoammonium phosphate, ammonium polyphosphate, triple superphosphate, Their derivatives, their oxides, salts and mixtures.

According to still other embodiments, the sulfur-based fertilizer may include elemental sulfur, ammonium thiosulfate, calcium sulfate, gypsum or derivatives thereof, oxides, salts, and mixtures.

According to another embodiment, macronutrients include, but are not limited to, one or more of carbohydrates, fats, and proteins, or salts, derivatives, and mixtures thereof.

According to another embodiment, micronutrients include, but are not limited to, one or more of: vitamins such as vitamin A, vitamin B, vitamin C, vitamin D, vitamin E, vitamin K, carotenoids; minerals such as boron , calcium, chloride, chromium, cobalt, copper, fluoride, iodine, iron, magnesium, manganese, molybdenum, phosphorus, potassium, selenium, sodium, zinc; and organic acids such as acetic acid, citric acid, lactic acid, malic acid, bile Alkali and taurine or its salts, derivatives and mixtures.

According to an embodiment, one or more of the fertilizer, the second pesticide active, the macronutrients and micronutrients or salts thereof are in a concentration range of 0.01% to 95% by weight of the total composition.

According to embodiments, thermally stable plasticizers include surfactants, polyethers, thermoplastics, resins, lubricants, protective colloids, water-soluble salts, nitrogen fertilizers, water-soluble polymers, water-soluble copolymers, complexing agents, carbohydrates One or more of the compounds or their derivatives and combinations.

According to an embodiment, the thermally stable plasticizer is selected from one or more of the following: polyoxyethylene oxide, vitamin E polyethylene glycol succinate, polyethylene glycol glycerol hydroxystearate, poly Ethylene glycol, poloxamer (block copolymer of polyoxyethylene-polyoxypropylene), polyoxyethylene-polyoxypropylene block copolymer, 1-phenyl-1,2-ethylene glycol, poly( Ethylene) adipate, ethylene oxide/propylene oxide block copolymer, ethylene-vinyl acetate copolymer, copovidone of vinylpyrrolidone and vinyl acetate, polyvinylcaprolactam-polyacetic acid Vinyl ester-polyethylene glycol graft copolymer, polyvinyl alcohol (PVA)-polyethylene glycol (PEG) graft copolymer, and hydroxypropyl cellulose.

According to another embodiment, the thermally stable plasticizer has a melting point of less than 250°C. According to further embodiments, the thermally stable plasticizer has a melting point of less than 200°C. According to further embodiments, the thermally stable plasticizer has a melting point of less than 150°C. According to further embodiments, the thermally stable plasticizer has a melting point of less than 100°C.

According to further embodiments, the thermally stable plasticizer has a melting point of less than 80°C. According to another embodiment, the thermally stable plasticizer has a melting point lower than the melting point of the agrochemical active ingredient.

According to an embodiment, the thermally stable plasticizer has a molecular weight of less than 100 gms/mol. According to an embodiment, the thermally stable plasticizer has a molecular weight of less than 500 gms/mol. According to an embodiment, the thermally stable plasticizer has a molecular weight of less than 1000 gms/mol. According to an embodiment, the thermally stable plasticizer has a molecular weight of less than 2000 gms/mol. According to another embodiment, the thermally stable plasticizer has a molecular weight of less than 5000 gms/mol. According to another embodiment, the thermally stable plasticizer has a molecular weight of less than 10,000 gms/mol. According to another embodiment, the thermally stable plasticizer has a molecular weight of less than 15,000 gms/mol. According to another embodiment, the thermally stable plasticizer has a molecular weight of less than 20,000 gms/mol. According to another embodiment, the thermally stable plasticizer has a molecular weight of less than 30,000 gms/mol. According to another embodiment, the thermally stable plasticizer has a molecular weight of less than 50,000 gms/mol. According to another embodiment, the thermally stable plasticizer has a molecular weight of less than 60,000 gms/mol. According to another embodiment, the thermally stable plasticizer has a molecular weight of less than 70,000 gms/mol. According to another embodiment, the thermally stable plasticizer has a molecular weight of less than 80,000 gms/mol. According to another embodiment, the thermally stable plasticizer has a molecular weight of less than 90,000 gms/mol. According to another embodiment, the thermally stable plasticizer has a molecular weight of less than 1,00,000 gms/mol. According to another embodiment, the thermally stable plasticizer has a molecular weight of less than 1,00,000 gms/mol. According to another embodiment, the thermally stable plasticizer has a molecular weight of less than 1,20,000 gms/mol. According to another embodiment, the thermally stable plasticizer has a molecular weight of less than 1,50,000 gms/mol. According to another embodiment, the thermally stable plasticizer has a molecular weight of less than 2,00,000 gms/mol.

According to an embodiment, the thermally stable plasticizer is water soluble. The term "water-soluble reactive plasticizer" includes any plasticizer that is soluble in water. According to an embodiment, the thermally stable plasticizer has a solubility in water of greater than 0.1 mg/liter at 20°C. According to an embodiment, the thermally stable plasticizer has a solubility in water of greater than 0.5 mg/liter at 20°C. According to an embodiment, the thermally stable plasticizer has a solubility in water of greater than 1 mg/liter at 20°C. According to an embodiment, the thermally stable plasticizer has a solubility in water of greater than 1 g/liter at 20°C. According to an embodiment, the thermally stable plasticizer has a solubility in water of greater than 10 g/liter at 20°C. According to an embodiment, the thermally stable plasticizer has a solubility in water of greater than 25 g/liter at 20°C.

According to another embodiment, the thermally stable plasticizer is present in a concentration range of at least 0.01% by weight of the total composition. According to another embodiment, the thermally stable plasticizer is present in a concentration range of at least 0.1% by weight of the total composition. According to another embodiment, the thermally stable plasticizer is present in a concentration range of at least 1% by weight of the total composition. According to another embodiment, the thermally stable plasticizer is present in a concentration range of at least 5% by weight of the total composition. According to another embodiment, the thermally stable plasticizer is present in a concentration range of at least 10% by weight of the total composition. According to another embodiment, the thermally stable plasticizer is present in a concentration range of at least 20% by weight of the total composition. According to another embodiment, the thermally stable plasticizer is present in a concentration range of at least 30% by weight of the total composition. According to another embodiment, the thermally stable plasticizer is present in a concentration range of at least 40% by weight of the total composition. According to another embodiment, the thermally stable plasticizer is present in a concentration range of at least 50% by weight of the total composition. According to another embodiment, the thermally stable plasticizer is present in a concentration range of at least 60% by weight of the total composition.

According to embodiments, agrochemically acceptable excipients, adjuvants or additives include wetting agents, dispersants, emulsifiers, binders, biocides, viscose, disintegrants, fillers, diluents, Plasticizers, spreading agents, surfactants, solvents, coating agents, pigments, dyes, anti-caking agents, thixotropic agents, anti-drifting agents, colorants, buffers, pH regulators, adhesives , fragrances, evaporation inhibitors, fertilizers, micronutrients, macronutrients, protective colloids, defoamers, antimicrobials, complexing agents, neutralizing agents, flavor enhancers, viscosity regulators, thickeners, penetration aids, Processing additives, chelating agents, wetting agents, preservatives, polyethers, lubricants, protective colloids, solvents, coating agents, antioxidants and stabilizers or derivatives, mold inhibitors, foaming agents, aggregation inhibitors, waxes, Fats and oils such as, for example, carnauba wax, stearic acid, stearyl alcohol or castor oil, anti-caking agents and mixtures thereof. Surfactants may include one or more of nonionic surfactants, anionic surfactants, or derivatives and mixtures thereof. Agrochemically acceptable excipients are commercially manufactured and available through various companies. According to an embodiment, the agrochemically acceptable excipient is present in a concentration range of 0.01% to 99% by weight of the total composition. According to an embodiment, the agrochemically acceptable excipient is present in a concentration ranging from 0.01% to 80% by weight of the total composition. According to an embodiment, the agrochemically acceptable excipient is present in a concentration ranging from 0.01% to 60% by weight of the total composition.

According to embodiments, the disintegrants used in the granule composition include, but are not limited to, one or more of: sodium bicarbonate/sodium carbonate, potassium bicarbonate/potassium carbonate or their combination with acids such as citric acid and fumarate Acid mixtures or salts, XL-10 Polyacrylate salts of cross-linked polyvinylpyrrolidone, microcrystalline cellulose, croscarmellose sodium and methacrylates. According to an embodiment, the dispersant is present in a concentration ranging from 0.01% to 80% by weight of the total composition.

According to embodiments, the dispersant used in the granular composition includes, but is not limited to, one or more of the following: polyvinylpyrrolidone, polyvinyl alcohol, lignosulfonate, phenolnaphthalenesulfonate, ethoxylated Alkylphenols, ethoxylated fatty acids, alkoxylated linear alcohols, polyaromatic sulfonates, sodium alkylaryl sulfonates, glycerides, maleic anhydride copolymers, phosphate esters, aryl sulfonic acids and Condensation products of formaldehyde, condensation products of formaldehyde condensation products of arylsulfonic acid and urea formaldehyde with naphthalenesulfonic acid, addition products of ethylene oxide and fatty acid esters, addition products of ethylene oxide and fatty acid esters Salts, condensed naphthalene sulfonates, lignin derivatives, lignosulfonates, naphthalene formaldehyde condensates, sodium salts of isodecylsulfosuccinate half ester, polycarboxylates, sodium alkylbenzenesulfonates , sodium salt of sulfonated naphthalene, ammonium salt of sulfonated naphthalene, salt of polyacrylic acid, salt of phenolsulfonic acid and salt of naphthalenesulfonic acid, sodium and ammonium salt of maleic anhydride copolymer and condensed phenolsulfonic acid Sodium salt and naphthalenesulfonate-formaldehyde condensate or its salts and derivatives. Dispersants are commercially manufactured and available through various companies.

Dispersants such as but not limited to The trademark and brand name of lid lignocalcium sulfate D425 Naphthalene formaldehyde condensate sodium available from PW (emery 5353), AF Sodium Modified Kraft Lignin, Sodium Alkyl Naphthalene Sulfonate and Alkyl Carboxylate EFW mixtures are commercially available. According to an embodiment, the dispersant is present in a concentration ranging from 0.01% to 80% by weight of the total composition.

According to embodiments, the wetting agent used in the granular composition includes, but is not limited to, one or more of the following: phenol naphthalene sulfonate, alkyl naphthalene sulfonate, sodium alkyl naphthalene sulfonate, sulfonated alkanes Sodium salts of carboxylic acids, polyoxyalkylated ethylphenols, polyoxyethoxylated fatty alcohols, alkyl sulfosuccinates, polyoxyethoxylated fatty amines, lignin derivatives, lignin sulfonates salts, alkane sulfonates, taurates, alkylbenzene sulfonates, salts of polycarboxylic acids, salts of sulfosuccinates, alkylnaphthalene sulfonates, phosphate condensation products of formaldehyde, sulfonol Acid condensates, acetylene glycol and alkylphenol ethoxylates, methyl oleyl taurate, alkylbenzene sulfonates, alkyl polyglycol ether sulfonates, ethoxylated silicones, alkanes Alkyl ether phosphates, alkyl ether sulfates and alkyl sulfosuccinic acid monoesters or their salts or derivatives. Wetting agents are commercially manufactured and available through various companies. Some of them are available under, but not limited to, the following brand names: Ag-Special Sodium Alkyl Naphthalene Sulfonate, 280LP silicone surfactant, Sodium XC alkylnaphthalene sulfonate, DS-10 sodium dodecylbenzenesulfonate, 301-10F sodium alkyl α-olefin sulfonate, SN naphthalene sulfonate sodium formaldehyde condensate, C14-C19 olefin sulfonate sodium salt (e.g. (R)Hostapur OS) and Sodium salt (eg (R)Genapol LRO). According to an embodiment, the humectant is present in a concentration ranging from 0.01% to 80% by weight of the total composition.

According to embodiments, illustrative examples of binders used in the granular composition may be selected from, but are not limited to, at least one of: carbohydrates such as monosaccharides, disaccharides, oligosaccharides, and polysaccharides; proteins; lipids; sugars Lipids; Glycoproteins; Lipoproteins; and combinations and derivatives of these. The carbohydrate binder may include one or more of glucose, mannose, fructose, galactose, sucrose, lactose, maltose, xylose, arabinose, trehalose, and mixtures thereof. Binders may also include corn syrup; celluloses such as carboxymethylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxymethylethylcellulose, hydroxyethylpropylcellulose, methylhydroxyethylcellulose Cellulose, methylcellulose; starches such as amylose, seagel, starch acetate, starch hydroxyethyl ether, ionic starch, long-chain alkyl starch, dextrin, maltodextrin, corn starch , amine starch, phosphate starch and dialdehyde starch; vegetable starches such as corn starch and potato starch; other carbohydrates such as pectin, pullulan, xylan, xanthan gum, glycogen, agar, alginic acid, algin , chitin, gum arabic, guar gum, karaya gum, tragacanth gum and locust bean gum. Binders can also include complex organic substances such as phenylnaphthalenesulfonate, lignin, and nitrolignin; derivatives of lignin such as lignosulfonate, illustratively calcium lignosulfonate and lignosulfonate sodium nitrite, and complex carbohydrate-based compositions, such as molasses, containing organic and inorganic ingredients. Suitable protein binders may illustratively include soy extract, zein, protamine, collagen and casein. Functional adhesives can also include synthetic organic polymers such as ethylene oxide polymers or copolymers, propylene oxide copolymers, polyethylene glycols, polyethylene oxides, polyacrylamides, polyacrylates, poly Vinylpyrrolidone, polyalkylpyrrolidone, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl acrylate, hydrated inorganics such as sodium silicate, sorbitol or urea, polylactic acid, polyethoxylated fatty acids, polyethoxylated Fatty alcohols and latex. However, those skilled in the art will understand that different adhesives may be used without departing from the scope of the present invention. Adhesives are commercially manufactured and available through various companies.

According to an embodiment, the binder is present in a concentration ranging from 0.01% to 80% by weight of the total composition.

According to embodiments, fillers or carriers include, but are not limited to, one or more of the following: attapulgite, kaolin, clay, montmorillonite, montromolite, bauxite, hydrated alumina, pearl rock, calcined alumina, diatomaceous earth, chalk, Fuller's earth, dolomite, diatomaceous earth (kiesulguhr), loess, pyrophyllite (prophyllites), talc, Glauber's salt, starch, lactose, white carbon black, sericite, slaked lime, carbonic acid Sodium, sodium bicarbonate, volclay, vermiculite, limestone, natural and synthetic silicates, calcium and magnesium silicates, titanium dioxide, hydroxides of calcium, magnesium, aluminum and titanium, silicates, Carbonates and sulfates, oxides of aluminium, titanium, magnesium, calcium and zinc, calcium and magnesium carbonates, and charcoal, silica, mica, clay, expanding and non-expanding clays, synthetic and silicon Algal silica, ammonium sulfate, sodium sulfate, potassium sulfate, calcium sulfate and barium sulfate, sand, gypsum and inorganic water-soluble salts. Fillers are commercially manufactured and available through various companies.

Commercially available silicates are Aerosil brand, Sipemat brand such as 50S and CALFLO E and airgel Fa.Cabot, kaolin 1777, aluminosilicate, 50s.

Preferred carriers include, but are not limited to, one or more of the following: attapulgite, kaolin, clay, montmorillonite, montmorillonite, bauxite, hydrated alumina, perlite and its derivatives, calcined Alumina, diatomaceous earth, chalk, fuller's earth, dolomite, diatomaceous earth, loess, pyrophyllite, talc, vermiculite, limestone, natural and synthetic silicates, silica, mica.

Fillers are commercially available under the trademark, but not limited to. According to an embodiment, the filler or carrier is present in a concentration ranging from 0.01% to 90% by weight of the total composition.

According to an embodiment, the filler has an oil absorption capacity of at least 30%. According to further embodiments, the filler has an oil absorption capacity greater than 35%. According to further embodiments, the filler has an oil absorption capacity greater than 50%. According to further embodiments, the filler has an oil absorption capacity greater than 75%. According to further embodiments, the filler has an oil absorption capacity greater than 100%. According to another embodiment, the filler has an oil absorption capacity of up to 175%. According to further embodiments, the filler has an oil absorption capacity of up to 160%. According to further embodiments, the filler has an oil absorption capacity of up to 115%. According to an embodiment, the filler has an oil absorption capacity in the range of 30% to 175%.

According to an embodiment, the composition optionally comprises an anti-caking agent such as Soap L Sodium Stearate, 700 polyoxyethylene (100) stearyl ether, OT-B Dioctyl Sodium Sulfosuccinate, L-77 silicone-polyether copolymer, sodium phosphate and ammonium phosphate, sodium acetate, sodium metasilicate, magnesium sulfate, zinc sulfate and calcium sulfate, magnesium hydroxide, anhydrous calcium chloride, molecular sieve, alkyl sulfo Sodium succinate, calcium and barium oxides, sodium carbonate or bicarbonate.

According to embodiments, the emulsifier or surfactant includes one or more of an ionic surfactant, a nonionic surfactant, and an amphoteric surfactant. Ionic surfactants include, but are not limited to, one or more of the following: carboxylates, alkyl carboxylates, fatty acid salts, fluorocarboxylates, alkyl sulfates, alkyl ether sulfates, sulfonic acids Salt, alkylbenzene sulfonate, alpha-olefin sulfonate, aromatic hydrocarbon sulfonate, naphthalene sulfonate, fatty alcohol sulfate, monoalkyl sulfosuccinate, alkyl sulfosuccinate, naphthalene Sulfonates, docusate sulfonates, phosphate esters, alkyl aryl ether phosphates, alkyl ether phosphates, quaternary ammonium salts, quaternized amine ethoxylates. Nonionic surfactants include, but are not limited to, one or more of the following: polyol esters, polyol fatty acid esters, polyethoxylated esters, polyethoxylated alcohols, polyethylene glycol, and polypropylene glycol block copolymers, poloxamers, polysorbates, alkyl polysaccharides such as alkyl polyglycosides and blends thereof, amine ethoxylates, sorbitan fatty acid esters, ethylene glycol and glycerides, glucose Glycoside alkyl ethers, sorbitan alkyl esters, sodium tallowate, polyoxyethylene glycol sorbitan alkyl esters, sorbitan derivatives, fatty acid esters of sorbitan (Span) and Its ethoxylated derivatives (Tween) and sucrose esters of fatty acids. More specifically, nonionic emulsifiers include, but are not limited to, one or more of the following: polyethylene glycol, glyceryl laurate, lauryl glucoside, nonylphenol polyethoxyethanol, nonylphenol polyethoxylate Glycol ethers, castor oil ethoxylates, polyglycol ethers, polyadducts of ethylene oxide and propylene oxide, blocks of polyalkylene glycol ethers and hydroxystearic acid Copolymer, Ethylene Oxide Propylene Oxide Block Copolymer, Tributylphenoxypolyethoxyethanol, Octylphenoxypolyethoxyethanol, Ethoxypropoxylated Tristyrylphenol (ethopropoxylatedtristyrlphenols), ethoxylated alcohols, polyoxyethylene sorbitan, sorbitan fatty acid esters, glycerin fatty acid esters, fatty acid polyglycerol esters, fatty acid alcohol polyglycol ethers, acetylene glycol, acetylene alcohol, oxidation Polyethylene block polymer, polyoxyethylene alkyl ether, polyoxyethylene alkyl aryl ether, polyoxyethylene styryl aryl ether, polyoxyethylene glycol alkyl ether, polyethylene glycol, polyoxyethylene Fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene glycerol fatty acid esters, polyoxyethylene hydrogenated castor oil or polyoxypropylene fatty acid esters; and mixtures thereof.

Anionic surfactants include, but are not limited to, one or more of the following: fatty acid salts, benzoates, polycarboxylates, salts of alkyl sulfates, alkyl sulfates, alkyl aryl sulfates Salt, alkyl diglycol ether sulfate, salt of alcohol sulfate, alkylsulfonate, alkylarylsulfonate, arylsulfonate, lignosulfonate, alkyldiphenyl ether disulfonate salts, polystyrene sulfonates, salts of alkyl phosphates, alkyl aryl phosphates, styryl aryl phosphates, salts of polyoxyethylene alkyl ether sulfates, polyoxyethylene alkyl aryl Ether sulfates, salts of polyoxyethylene alkyl aryl ether sulfates, polyoxyethylene alkyl ether phosphates, salts of polyoxyethylene alkyl aryl phosphates, salts of polyoxyethylene aryl ether phosphates, and Salts of formaldehyde-condensed naphthalenesulfonic acids or alkylnaphthalenesulfonic acids condensed with formaldehyde and mixtures thereof.

Nonionic emulsifiers or surfactants commercially available under, but not limited to, the following trademarks may also be used: Atlas G5000 and TERMUL 5429, TERMUL 2510, 118、 X, OX-080, C 100, EL 200, Arlacel P135, Hypermer 8261, Hypermer B239, Hypermer B261, Hypermer B246sf, Solutol HS15, Promulgen ^TM D, Soprophor 7961P, Soprophor TSP/461, Soprophor TSP/724, Croduret 40, Etocas ON 200, CHEM, Etocas RIC2, Etocas RIC 29 OE-20, Triton ^TM N-101, Tween 20, Tween 40, Tween 60, Tween 65, Tween 80, Span20, Span40, Span60, Span80, Span83, Span85, Span120, Triton ^™ . The amphoteric surfactant may comprise one or more of betaine, imidazoline, amphoteric alkyl acetate and propionate, amphoteric (di)acetate, and dipropionate, lecithin kind. According to an embodiment, the surfactant or emulsifier is present in a concentration ranging from 0.01% to 90% by weight of the total composition.

According to an embodiment, the antioxidant may be selected from, but not limited to, one or more of the following: amino acids (such as glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles and imidazole derivatives ( e.g. urocanine), peptides such as D,L-carnosine, D-carnosine, L-carnosine and their derivatives (e.g. anserine), carotenoids, carotene (e.g. α-carotene, β-carotene, tomato erythrophyll) and its derivatives, lipoic acid and its derivatives (such as dihydrolipoic acid), aurothioglucose, propylthiouracil and additional thio compounds (such as thioglycerol, thiosorbitol, thio Glycolic acid, thioredoxin, glutathione, cysteine, cystine, cystamine and its sugars, N-acetyl, methyl, ethyl, propyl, pentyl, butyl, lauryl, palmitoyl, oleyl, γ-linoleyl, cholesteryl and glyceryl esters) and their salts, dilauryl thiodipropionate, distearyl thiodipropionate, sulfur Dipropionic acid and its derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts), and sulfoxides at very low tolerated doses (e.g. pmol/kg to pmol/kg) Amine compounds (e.g. buthionine sulfoximine, homocysteine sulfoximine, buthionine sulfone, pentathionine sulfoximine, hexathionine sulfoximine, hexathionine sulfoxide imines), but also metal chelators (e.g. alpha-hydroxy fatty acids, EDTA, EGTA, phytic acid, lactoferrin), alpha-hydroxy acids (e.g. citric acid, lactic acid, malic acid), humic acids, bile acids, Bile extract, gallates (such as propyl gallate, octyl gallate, and lauryl gallate), flavonoids, catechin, bilirubin, biliverdin and its derivatives, unsaturated Fatty acids and their derivatives (such as gamma-linolenic acid, linolenic acid, arachidonic acid, oleic acid), folic acid and its derivatives, hydroquinone and its derivatives (such as arbutin), ubiquinone and ubiquinol and their Derivatives, vitamin C and its derivatives (such as ascorbyl palmitate, ascorbyl stearate, ascorbyl dipalmitate, ascorbyl acetate, magnesium ascorbyl phosphate, sodium and magnesium ascorbate, disodium ascorbyl phosphate and ascorbyl sulfate Disodium, potassium ascorbyl tocopheryl phosphate, chitosan-ascorbyl ester), erythorbic acid and its derivatives, tocopherol and its derivatives (e.g. tocopheryl acetate, tocopheryl linoleate, tocopheryl oleate and tocopherol succinate, tocopherol-5, tocopherol-10, tocopherol-12, tocopherol-18, tocopherol-50, tocophersolan), vitamin A and derivatives (such as vitamin A palmitate), coniferyl benzoate of benzoin resin, rutin, rutinic acid and its derivatives, disodium rutin disulfate, cinnamic acid and its derivatives (such as ferulic acid, ethyl ferulate, caffeeic acid), kojic acid, chitosan glycolate and chitosan salicylate, butylated hydroxytoluene, butylated hydroxyanisole, nordihydroguaiaci cacid), nordihydroguaiaretic acid, trihydroxybutyrophenone, uric acid and its derivatives, mannose and its derivatives, selenium and selenium derivatives (such as selenomethionine ), stilbene and stilbene derivatives (eg stilbene oxide, trans-stilbene oxide). According to the invention, suitable derivatives (salts, esters, sugars, nucleotides, nucleosides, peptides and lipids) comprising these antioxidants together with these specific active ingredients or plant extracts (e.g. tea tree oil, Rosemary Extract and Rosmarinic Acid). Antioxidants are commercially manufactured and available through various companies.

According to an embodiment, the antioxidant is present in a concentration ranging from 0.01% to 60% by weight of the total composition.

According to embodiments, the composition may also comprise a pH adjusting agent or a buffer or neutralizing agent. pH buffering or neutralizing agents may include both acids and bases of organic or inorganic origin. According to embodiments, pH buffering or neutralizing agents include, but are not limited to, organic acids, inorganic acids, and alkali metal compounds or salts. The organic acid may include, but is not limited to, one or more of citric acid, malic acid, adipic acid, cinnamic acid, fumaric acid, maleic acid, succinic acid, and tartaric acid, or salts or derivatives thereof, and Monobasic, dibasic or tribasic salts of these acids or derivatives thereof. Suitable salts of these acids may be soluble or meltable salts and include those in which one or more acidic protons are replaced by cations such as sodium, potassium, calcium, magnesium and ammonium and mixtures thereof. Alkali metal compounds may include alkali metal hydroxides such as sodium hydroxide and potassium hydroxide, alkali metal carbonates such as sodium carbonate, magnesium carbonate and potassium carbonate, alkali metal bicarbonates such as sodium bicarbonate and alkali metal phosphoric acid Salts such as sodium phosphate and mixtures thereof. According to embodiments, salts of inorganic acids include, but are not limited to, one or more of the following: alkali metal salts such as lithium chloride, sodium chloride, potassium chloride, lithium nitrate, sodium nitrate, potassium nitrate, lithium sulfate, Sodium sulfate, potassium sulfate, sodium monohydrogen phosphate, potassium monohydrogen phosphate, sodium dihydrogen phosphate, potassium dihydrogen phosphate, etc.; alkaline earth metal salts such as magnesium chloride, calcium chloride, ammonium sulfate, ammonium monohydrogen phosphate, ammonium dihydrogen phosphate, etc. .

According to another embodiment, the present invention also relates to a process for preparing a stable granular composition. The process includes mixing and blending at least one agrochemical active ingredient with at least one thermally stable polymer to obtain a mixture, wherein the agrochemical active includes at least one of a water-soluble active ingredient or a water-sensitive active ingredient. A sort of. Blend pre-blended fillers and surfactants into the mixture. The overall mixture of active, plasticizer, filler and surfactant, disintegrant is then heated in an oil bath at a temperature suitable for melting the thermally stable polymer or plasticizer. The molten mixture is then extruded through a medium pressure extruder to give a stable agrochemical granular composition; such that the granular composition has a wettability of less than 20 minutes.

Careful management of process conditions is required in order to give a final granular product with the desired properties of disintegration time, wettability, dispersibility and floatation. One skilled in the art can use the appropriate amount of pressure during extrusion to provide the desired composition.

Example:

Preparation Examples:

The following examples illustrate the basic method and versatility of the compositions of the present invention.

1. Granular composition comprising 6% Cartap hydrochloride

Table 1:

Also, 65 parts by weight of cartap hydrochloride and 22 parts by weight of citric acid were thoroughly mixed to obtain mixture A. To this mixture was added 713 parts by weight of fillers including dolomite, diatomaceous earth, perlite, and Witconate ^™ (sodium alkylaryl sulfonate) and mixed well. An additional 200 parts by weight of PEG 4000 was added. The mixture was then heated and extruded and cooled to obtain a granular composition of 6.5% cartap hydrochloride.

2. Granular composition comprising 4% cartap hydrochloride and 72.5% sulfur

Table 2:

765 parts by weight of the sulfur active ingredient and 67 parts by weight of a delta filler comprising dolomite, diatomaceous earth, perlite and Witconate ^™ (sodium alkylaryl sulfonate) were thoroughly mixed to obtain Mixture A . 45 parts by weight of cartap hydrochloride were also mixed with 20 parts by weight of citric acid to obtain mixture B. Mixture A and Mixture B were then combined together, and 100 parts by weight of PEG 4000 were added to the combination. The mixture was then heated and extruded and cooled to obtain a granular composition of 76.5% sulfur and 4.5% cartap hydrochloride.

Comparison of physical properties:

Bioefficacy Results:

Example 1: Biological efficacy of cartap hydrochloride granules according to an embodiment of the present invention:

A field trial was conducted on rice in the Hissar district of Haryana, India, to evaluate the effectiveness of cartap hydrochloride granules prepared according to embodiments of the present invention, and sulfur-plus cartap hydrochloride granules according to embodiments of the present invention. Experiments were also performed using sulfur 90% WG alone and cartap hydrochloride 4% granules alone used as standards for comparison as well as untreated controls. The treatment also included a composition of sulfur 70% + cartap hydrochloride 4% WP prepared according to the embodiment of 251/MUM/2011. The treatment also includes compositions according to the embodiments of EP1882414, EP2460408 and US6703350B which disclose granular compositions of cartap.

Treatments were performed in a randomized block design and all agronomic practices were kept the same for all treatments. Treatments were applied when a large borer (Scirpophaga incertulas) Walker population per leaf was observed. All agronomic practices were adopted as recommended.

The larvae of the C. borer Walker cause cardiac death during the vegetative phase and white-eared heads during the reproductive phase. Rice plants can compensate if dead heart infection does not exceed 10%, however, white ear loss is irreparable. % of white ear head infection was observed, as well as 5 plant damage due to leaflets. Table 1A and Table 1B represent the observations regarding white ear infection and lobules, respectively.

The treatment was carried out by sowing the composition twice on the 30th day and the 60th day after rice transplantation. To avoid mixing of treatments, a pseudo-bank border of about 20 cm to 30 cm thick was prepared around the plot with granular insecticide treatment. Both its application and efficacy are evaluated.

The processing applied is shown in the table below:

Table 1A: About the efficacy of Baiertou

Note: DAT - days after transplantation

Note that compared to treatments 6 and 7 with granules of cartap 4%, cartap 6% and cartap 8% prepared according to the embodiments of EP1882414, EP 2460408 and US6703350 and applied at significantly higher applied doses Compared with the application of both treatment 1 and treatment 2 of 4% cartap hydrochloride granules and 6% cartap hydrochloride granules of the composition applied according to an embodiment of the present invention at a significantly reduced application dose, the effect on controlling white Excellent results have been achieved on the ear tips.

Furthermore, compared to treatment 5 with sulfur 50% + cartap hydrochloride 7.5% GR per hectare at 10000 + 1500 g.a.i. Much higher doses of sulfur and cartap alone were applied in treatment 8 vs treatment 9 at 7500 + 400 g.a.i. of sulfur per hectare 75% + cartap 4% GR at 75 days post transplant (treatment 3) And Sulfur 75% + Cartap 6% GR (Treatment 4) at 7500 + 600 g.a.i. per hectare provided better control of white ear infection.

Table 1B: Efficacy on leaflets

Note: DAT - days after transplantation

As can be observed from Table 1B, compared with the individual treatments with sulfur (treatment 9) and cartap (treatment 10), and with the preparation according to the embodiments of EP1882414, EP 2460408 and US6703350 and at significantly higher Application doses of cartap 4%, cartap 6% and cartap 8% granules compared to treatment 6, treatment 7 and treatment 8 for applications prepared with embodiments according to the present invention at significantly lower Treatment 1 (with 4% cartap hydrochloride granules), treatment 2 (with 6% cartap hydrochloride granules), treatment 3 (with sulfur 75% + cartap hydrochloride 4% granules) and treatment 4 (with sulfur 75% + cartap hydrochloride 6% granules), the control of plant damage due to small leaves was excellent.

In addition to the control of larvae and leaflets of pests of the genus Chilobarer, the combination products of sulfur + cartap hydrochloride at different concentrations according to the invention also showed valuable effects on physiological factors, such as improved rice leaves (green) and an increase in the number of tillers, which contributes to higher yields.

Below is a tabular presentation indicating the yield by tiller number at 60 DAT (days after transplantation).

Table 1B:

The maximum number of tillers was observed with treatment 2 application of 7500+600 g.a.i. per hectare of Sulfur 75% + Cartap 6% GR. Application of Treatment 1 with Sulfur 75% + Cartap 4% GR at 7500 + 400 g.a.i. per hectare also showed a significant increase in the number of tillers observed.

The crops also exhibited increased chlorophyll content due to the combined application of sulfur and cartap hydrochloride at different concentrations.

In fact, the above composition is aimed at simultaneously managing the damage caused by stem borers and leaf folds, as well as the need for sulfur fertilizers in the early stages of plant growth, thus making the combination It is more economical and beneficial to the end user.

The above composition also limits overloading of carriers such as sand, which is present at levels as high as 90% in cartap hydrochloride compositions alone, which is effectively a waste.

Therefore, it can be concluded that the water-dispersible granule compositions according to embodiments of the present invention show significantly enhanced bioefficacy even at reduced application At lower doses, the effect lasts for a longer duration.

In light of the foregoing, it will be observed that many modifications and variations can be made without departing from the true spirit and scope of the novel concept of the invention. It is to be understood that no limitation is intended or should be inferred with respect to the particular embodiments shown.

Claims (19)

1. a kind of stable agriculture chemistry particulate composition, includes:

I. at least one first agricultural chemical activity object ingredient, wherein the first agricultural chemical activity object includes water-soluble active At least one of object ingredient or water sensitivity active ingredient；

Ii. at least one heat-staple plasticizer, wherein the plasticizer, which has, is greater than 20 DEG C and the fusing point less than 150 DEG C；

Iii. acceptable excipient at least one agriculture chemistry；

Wherein the particulate composition has the wetability less than 20 minutes.

2. stable agriculture chemistry particulate composition as described in claim 1 is less than wherein the particulate composition has 99% floatability.

3. stable agriculture chemistry particulate composition as described in claim 1, wherein the particulate composition was at 10 minutes There is the floatability less than 99% in period.

4. stable agriculture chemistry particulate composition as described in claim 1, wherein the particulate composition has less than 30 The disintegration time of minute.

5. stable agriculture chemistry particulate composition as described in claim 1, wherein the composition, which has, is less than 1.5gms/ The bulk density of ml.

6. stable agriculture particulate composition as described in claim 1, wherein the composition at least 20% it is wear-resisting Property.

7. stable agriculture chemistry particulate composition as described in claim 1, wherein the water-soluble active ingredient is in water In have greater than every liter of water of 0.1mg solubility.

8. stable agriculture chemistry particulate composition as described in claim 1, wherein including in the particulate composition The decomposition of the active matter is under the conditions of accelerating storage less than 20%.

9. stable agriculture chemistry particulate composition as described in claim 1, wherein the heat-staple plasticizer be selected from by One of following or more the group of composition: surfactant, polyethers, thermoplastic material, resin, lubricant, protecting colloid, Water soluble salt, water-soluble polymer, nitrogenous fertilizer, water solubility copolymer, block polymer, polyethers, complexing agent, carbohydrate spread out Biology.

10. stable agriculture chemistry particulate composition as described in claim 1, wherein the heat-staple plasticizer be selected from One of lower or more: polyoxyethylene oxide, vitamin E polyethylene glycol succinic acid ester, polyethylene glycol glycerol hydroxyl are hard Resin acid ester, polyethylene glycol, poloxamer (block copolymer of PULLRONIC F68), PULLRONIC F68 block Copolymer, 1- phenyl -1,2- ethylene glycol, poly- (ethylene) adipate ester, ethylene oxide/propylene oxide block copolymer, ethylene-second The poly- acetic acid second of vinyl acetate copolymer, the copolyvidone of vinyl pyrrolidone and vinyl acetate, Vinylcaprolactam homopolymer- Enester-polyethyleneglycol-graft copolymer, polyvinyl alcohol (PVA)-polyethylene glycol (PEG) graft copolymer and hydroxypropyl cellulose.

11. stable agriculture chemistry particulate composition as described in claim 1, wherein the first agricultural chemical activity object at Be selected from one of following or more: insecticide, fungicide, herbicide, plant growth regulator, nematicide, Acaricide, insect growth regulator, IGR, safener, herbicide or other pesticide activity objects mixed.

12. stable agriculture chemistry particulate composition as described in claim 1, wherein the first agricultural chemical activity object at It is selected from one of following or more: anabasine insecticide, oxygroup phenoxy group acid esters, cyclohexanedione oxime herbicide, sulphur Sulfonylurea compound, cloquintocet herbicide-safener, HPPD inhibit herbicide, Phenylpyrazole, nereistoxin similar to object insecticidal Agent and organophosphorus ester insecticide.

13. stable agriculture chemistry particulate composition as described in claim 1, wherein the first agricultural chemical activity object at Dividing is one of hydrochloric acid cartap, cartap and pinoxaden or more.

14. stable agriculture chemistry particulate composition as described in claim 1, wherein the second agricultural chemical activity object at Dividing is Fipronil.

15. stable agriculture chemistry particulate composition as described in claim 1, wherein the composition also includes in following It is one or more of: fertilizer, the second pesticide activity object ingredient, macronutrient and micronutrient.

16. the purposes of agriculture chemistry particulate composition as described in claim 1, wherein the composition be in following at least It is a kind of: fertilizer composition, nutrition composition, crop production compositions, composition pesticide, plant hardening agent composition, soil Conditioner composition and yield enhancer compositions.

17. a kind of technique for preparing stable particulate composition, the technique include:

A. at least one agricultural chemical activity object ingredient and at least one heat stabilized polymer are mixed and blended to be mixed Object is closed, wherein the agricultural chemical activity object includes at least one in water-soluble active ingredient or water sensitivity active ingredient Kind；

B. it heats and the cooling mixture is to obtain stable agriculture chemistry particulate composition；

Wherein the particulate composition has the wetability less than 20 minutes.

18. technique as claimed in claim 26, wherein the step that is mixed and blended further includes by one or more of agriculturals Chemical excipient is added in the mixture.

19. a kind of cover crop or the method for improving its health or yield, the method includes at stable particulate composition Manage at least one of plant, crop, plant propagation material, seed, seedling or surrounding soil, the stable particulate composition Include:

I. at least one agricultural chemical activity object ingredient, wherein the agricultural chemical activity object include water-soluble active ingredient or One of water sensitivity active ingredient or more；

Ii. at least one heat-staple plasticizer；With,

Iii. acceptable excipient at least one agriculture chemistry；Wherein the particulate composition has the profit less than 20 minutes It is moist.