CN110507406A - Cryoablation catheter and application thereof - Google Patents

Abstract

The present invention relates to a cryoablation catheter and its application. The cryoablation catheter includes an expandable member and a pipeline provided with a thermal insulation area and an ablation area, and the pipeline includes an air inlet pipeline and an Return air pipeline; the expandable member is provided with an expanded state and a contracted state, the freezing medium enters the expandable member from the intake pipe to make it into an expanded state, the heat insulation area isolates the cold transfer of the freezing medium, and the ablation area realizes the cold transfer. In cryoablation, the cryogenic medium is returned through the return gas line. The above-mentioned cryoablation catheter in the expanded state has a larger balloon for sufficient cold and heat exchange, so that the cryo-injury can penetrate the entire airway wall, and it provides an ablation and thermal insulation zone to minimize unnecessary tissue damage. Injury, the cryoablation catheter is especially suitable for pulmonary vagus nerve injury. It uses an endoscope combined with cryoablation method to effectively control the complications of the ablation method while achieving nerve injury.

Description

A cryoablation catheter and its application

technical field

The invention relates to the technical field of cryoablation, in particular to a cryoablation catheter and its application.

Background technique

Cryoablation is a treatment that destroys tissue in a controlled manner by freezing local tissue. When cryoablation is used in the airway, compared with thermal ablation, freezing is not easy to cause cartilage damage, and airway softening and collapse rarely occur, preventing secondary dynamic stenosis; cryotherapy is less likely to cause adhesion between the frozen part and surrounding tissues ; The cryotherapy with controllable depth is not easy to cause serious damage to the adjacent large blood vessels and trachea, it is not easy to cause perforation and bleeding, and it is conducive to tissue repair; cryoablation does not promote the proliferation of granulation tissue, and is not easy to produce scar tissue.

Obstructive pulmonary disease, including asthma, emphysema, or chronic bronchitis, affects more than 25 million people in the United States, and the total cost of these diseases is currently estimated at more than $20 billion. The incidence is increasing due to factors such as air pollution and smoking.

Chronic obstructive pulmonary disease (COPD) is a common preventable and treatable disease characterized by persistent airflow limitation, progressive development of airflow limitation, and airway and lung response to toxic particles or gases associated with an enhanced chronic inflammatory response. The hallmark of asthma is an acute attack of dyspnea caused by acute constriction of the smooth muscle lining the bronchi (the air passages of the lungs), reducing airway diameter and increasing airflow resistance. Bronchoconstriction in asthma is "reversible" in that acute constriction can be reversed by bronchodilator drugs or over time (after removal of the stimulus that caused the constriction). However, asthma is chronically manifested by inflammation, hypertrophy or hyperactivity of smooth muscle.

At present, the main treatment methods are drug therapy, rehabilitation therapy, lung volume reduction surgery, or surgical treatment (such as surgical removal of the pulmonary nerve, which can completely or partially invalidate the function of the nerve, which can improve asthma or emphysema). method, or the therapeutic effect is not obvious, or serious complications may occur.

Studies have shown that damage to the vagus nerve in the lungs can inhibit the release of acetylcholine and smooth muscle contraction, thereby improving the symptoms of asthma and COPD, and improving lung function. With the development and popularization of cryoablation technology, cryoablation provides new ideas and methods for the treatment of COPD. Due to the above characteristics and advantages of cryoablation, it is more suitable for airway tissue and more suitable for ablation and injury of pulmonary vagus nerve. Therefore, cryoablation is a suitable method for modeling of pulmonary vagus nerve injury.

At present, most of the frozen parts of the existing cryoablation catheters are balloons or probes, and the entire contact part of the balloon or probe is its damage range. When using this method to target tissue, the entire frozen part will ablate and damage the tissue without distinction. It will cause greater unnecessary damage. For example, Chinese patent CN201710816284.5 discloses a cryoablation catheter with a thermal insulation capsule, which includes: a tube body and a freezing unit, and the tube body includes a cold source inlet cavity and a cold source return cavity extending along its axial direction and a filling chamber, the freezing unit is arranged on the distal part of the tube body, including a first bladder in fluid communication with the cold source inlet chamber and the cold source return air chamber and a first bladder communicating with the filling chamber The thermal insulation capsule, when the first capsule expands, fills the thermal insulation capsule with an insulating medium through the filling cavity, so that the area occupied by the thermal insulation capsule becomes an area that isolates energy transmission, thereby preventing the freezing unit from moving to The energy transfer in the space corresponding to the heat-insulating area, although the patent sets up a heat-insulating capsule for energy isolation, the first capsule used for ablation is still in the overall form, and there is still a large unnecessary damage caused by a large damage range. problem of damage.

Contents of the invention

In order to overcome the shortcomings and deficiencies in the prior art, the present invention provides a cryoablation catheter and its related applications. The cryoablation catheter is provided with an ablation area and a heat insulation area at the frozen site. The length is as short as possible and flattened (because there is a large cavity for sufficient heat exchange, the freezing depth can be guaranteed), forming flat damage in the radial direction, which can effectively reduce unnecessary tissue damage; the heat insulation area can prevent freezing medium The cold transfer can further reduce the damage to unnecessary tissues, and realize the complete ablation of the target tissue with as little damage as possible, especially suitable for the lung vagus nerve tissue.

To achieve the above object, the present invention adopts the following technical solutions:

The first aspect of the present invention is to provide a cryoablation catheter, which includes an expandable member and a pipeline connected to the expandable member. The expandable member is provided with a thermal insulation area and an ablation area, and the pipeline includes An air intake pipeline and a return air pipeline, both of which are in communication with the inner chamber of the expandable member.

Further, the expandable member is provided with an expanded state and a contracted state, the refrigerated medium enters the expandable member through the air inlet pipeline, making the expandable member enter the expanded state, and the thermal insulation area isolates the refrigerated medium The cold transfer in the ablation area realizes cold transfer for cryoablation to achieve the purpose of treatment, and the freezing medium flows back through the return air pipeline.

Further, the end of the air intake pipeline extends into the expandable member, and its distal end is fixedly and sealingly connected with the distal end of the expandable member, and at least one air intake pipeline is opened inside the expandable member. outlet,. Furthermore, at least two symmetrically distributed air outlets are opened on the same axial plane position of the air intake pipeline, or at least one air outlet is respectively opened on different axial plane positions of the air intake pipeline.

Further, the air return pipeline is sleeved outside the air intake pipeline or the air return pipeline (22) is arranged side by side with the air intake pipeline (21), and the far end of the air return pipeline (22) It is fixedly connected with the proximal end of the expandable member and communicates with the inner chamber of the expandable member.

Further, temperature sensors and/or pressure sensors are arranged on the expandable member along the circumferential direction. The type of temperature sensor and/or pressure sensor is any suitable sensor conventionally used in the art, wherein, temperature sensor is used for real-time monitoring the surface temperature of expandable member; Pressure sensor is used for real-time monitoring expandable member to airway wall pressure.

Further, at least one scale line is provided on the outer surface of the distal end of the pipeline. Furthermore, the scale lines are printed scale lines or engraved scale lines, and the above scale lines are used for measuring distances.

Further, the wall thickness of the thermal insulation area is greater than the wall thickness of the ablation area. Among them, the materials of the two areas can be the same or different. From the perspective of heat transfer, the heat transfer effect of the area with thicker wall thickness is worse than that of the area with thin wall thickness, that is, the heat insulation area can play a certain heat insulation effect.

Further, the wall thicknesses of the thermal insulation area and the ablation area are the same, the thermal insulation area uses a material with a low thermal conductivity, and the ablation area uses a material with a high thermal conductivity. It can be understood that the above-mentioned material can be any suitable material conventionally used in this field, for example, the material with low thermal conductivity is polyvinyl chloride, and its thermal conductivity: 0.14W/m×K; the material with high thermal conductivity is polyamide , Its thermal conductivity: 0.25W/m×K.

Further, the heat insulation area uses a multi-layer structure in which the middle layer material is a heat insulation material with air holes. It can be understood that the above-mentioned thermal insulation material with air holes can be any suitable material conventionally used in this field. For example, most polymer materials used in thermal insulation materials are made porous, such as: high foaming polypropylene, foam Polystyrene, polyurethane foam, etc.

Further, the outer diameter of the ablation area is larger than the outer diameter of the thermal insulation area. Furthermore, the outer diameter of the ablation area is 1.05 to 1.5 times the outer diameter of the heat insulation area; more preferably, the outer wall of the ablation area is a hemispherical or approximately hemispherical structure protruding outward.

Further, there are one or more ablation areas, and the ablation areas are located in different planes along the axial direction, which separate the expandable member into ablation areas and heat insulation areas that are distributed in a radial direction.

The second aspect of the present invention is to provide a cryoablation device containing any one of the above-mentioned cryoablation catheters, wherein the cryoablation device includes a freezing medium delivery device commonly used in the art, which communicates with the air inlet pipeline, and It includes a freezing medium return device conventionally used in the field, which communicates with the air return pipeline; in addition, it also includes a guide device and a positioning device for a cryoablation catheter conventionally used in the field.

The third aspect of the present invention is to provide an application of any one of the above-mentioned cryoablation catheters in constructing a pulmonary vagus nerve injury model, wherein the pulmonary vagus nerve injury model is an isolated lung tissue vagus nerve injury model, and the isolated Lung tissue is derived from large animals, such as cattle, sheep, and pigs.

The fourth aspect of the present invention is a method for pulmonary vagus nerve injury using any one of the above-mentioned cryoablation catheters, which includes the following steps: determining the location of the target tissue; introducing the expandable member of the cryoablation device and pushing it to the target Tissue; Confirm that the ablation area of the expandable component coincides with the target tissue; Input the freezing medium to make the expandable component into an expanded state, start the cryoablation procedure, and perform cryoablation on the designated part to complete the injury of the vagus nerve in the lung.

Further, the above-mentioned target tissue is isolated lung tissue.

Further, the method for lung vagus nerve injury includes the following steps: determining the target position of the isolated lung tissue; introducing the cryoablation catheter under endoscopic monitoring, and the cryoablation catheter includes an expandable member and a tubing connected to a proximal end of the expandable member configured to have an expanded state and a contracted state, pushes the cryoablation catheter to target tissue, and extends the distal end of the cryoablation catheter distally beyond The distal part of the endoscope; confirm that the damaged part coincides with the target tissue; input the freezing medium, make the expandable member into an expanded state and start the cryoablation procedure, the cryoablation procedure includes a cryoablation process and a rewarming process, and the specified Cryoablation is performed on the site to achieve the purpose of damaging the vagus nerve of the lung.

Further, the target tissue may be a plurality of target tissues, which may be, but not limited to, the left main bronchus, the right main bronchus, or both the left and right main bronchus.

Further, the target tissue may be cryoablated all at once, or may be cryoablated several times.

Further, the step of introducing the endoscope may be combined with lung navigation technology.

Further, the step of introducing the cryoablation catheter may be introduced through the channel of the endoscope itself, or the cryoablation catheter may be introduced in parallel with the endoscope.

Further, the step of confirming that the surgical site matches the target tissue can be observed directly, or can be combined with various detection methods, such as X-ray machine.

Further, start the cryoablation procedure, the cryoablation procedure includes the cryoablation process and the rewarming process, and perform cryoablation on the designated part to achieve the purpose of injuring the lung vagus nerve, and the same target tissue can be repeatedly injured by cryoablation, so as to To achieve a better effect of cryoablation injury.

Further, the freezing medium is liquid nitrogen, or other suitable freezing medium.

The present invention adopts above-mentioned technical scheme, has following technical effect:

1. Using the interventional method of endoscope combined with cryoablation, while achieving damage to the vagus nerve in the lungs, it achieves small trauma, short operation time, simple operation, high safety, and effectively controls surgical complications;

2. The expandable member is provided with a heat insulation area and an ablation area. Since the large lumen of the expandable member is used for sufficient heat exchange, the length of the ablation area in the axial direction can be shorter, which can realize the damage of the vagus nerve in the lungs. , and minimize unnecessary tissue damage;

3. The freezing device is equipped with a thermal insulation area, which isolates the transfer of cold energy during the ablation process and further protects unnecessary damaged tissues;

4. The central cross-section of the ablation area can be in different planes along the axial direction, that is, the discontinuous distribution along the axial direction forms intermittent damage in the axial direction (incomplete circumferential damage). The discontinuous damage can reduce the damage stimulation to the airway wall tissue, It is not easy to cause complications such as perforation and airway collapse, and at the same time, it can ensure the damage of the vagus nerve in the lungs and block nerve conduction.

Description of drawings

Fig. 1 is a schematic structural diagram of a cryoablation catheter in an embodiment of the present invention.

Fig. 2 is a cross-sectional view of the cryoablation catheter in an embodiment of the present invention.

Fig. 3 is an enlarged view at A of the cryoablation catheter shown in Fig. 2 .

Fig. 4 is a cross-sectional view of a cryoablation catheter in another embodiment of the present invention.

Fig. 5 is a cross-sectional view of a cryoablation catheter in another embodiment of the present invention.

Fig. 6 is a cross-sectional view of a cryoablation catheter in another embodiment of the present invention.

Fig. 7 is a cross-sectional view of a cryoablation catheter in another embodiment of the present invention.

Fig. 8 is a cross-sectional view of a cryoablation catheter in another embodiment of the present invention.

Wherein, reference sign is:

Expandable member 1 ; heat insulation area 11 ; ablation area 12 ; pipeline 2 ; air inlet pipeline 21 ; air return pipeline 22 ;

Detailed ways

The present invention relates to a cryoablation catheter, comprising an expandable member and a pipeline connected to the expandable member, a thermal insulation area and an ablation area are set on the expandable member, and the pipeline includes an air inlet pipeline and a return air pipe The air inlet pipeline and the air return pipeline are both in communication with the inner chamber of the expandable member. The present invention also relates to the application of the above-mentioned cryoablation catheter.

The specific implementation manners of the present invention will be further described below in conjunction with the drawings and examples. The following examples are only used to illustrate the technical solution of the present invention more clearly, but not to limit the protection scope of the present invention.

Example 1

This embodiment is a cryoablation catheter with a preferred structure. As shown in Figures 1 to 3, the cryoablation catheter described in this embodiment includes an expandable member 1 and a pipeline 2 connected to the proximal end of the expandable member 1. The expandable member 1 is provided with partitions on both sides. The thermal region 11 and the ablation region 12 located in the middle, the heat insulation region 11 and the ablation region 12 together constitute the expandable member 1, the main body of the expandable member 1 is in the form of a cylinder, and the two ends are respectively in the form of cones The sealing structure, the ablation area 12 is in the form of a 360° annular band, the number of the ablation area 12 is one, and its width is about 1/4 to 1/3 of the length of the main body of the expandable member 1; wherein, the The heat insulation area 11 and the ablation area 12 are made of the same material, specifically polyamide, but the wall thickness of the heat insulation area 11 is greater than the wall thickness of the ablation area 12, specifically about 2 to 4 times. From the perspective of heat transfer, the wall thickness The heat transfer effect of the thicker area is worse than that of the thinner area, that is, the heat insulation area 11 can play a certain heat insulation effect.

In this embodiment, the pipeline 2 includes an air inlet pipeline 21 and a gas return pipeline 22 respectively communicated with the inner chamber of the expandable member 1, the end of the air inlet pipeline 21 extends into the expandable member 1, and its distal end is connected to The distal end of the expandable member 1 is fixed and sealed, and two symmetrically distributed air outlets 211 are provided on the side wall of the air intake pipeline 21 located in the middle of the expandable member 1, and the return air pipeline 22 is sleeved on the air intake pipeline 21 The outer part, the distal end of which is fixedly connected with the proximal end of the expandable member, and the specific structure is that a sleeve extending from the conical end of the proximal end of the expandable member 1 is sealed and sleeved on the outside of the return air pipeline 22, and the return The distal end of the airway 22 communicates with the internal lumen of the expandable member 1 at its proximal end.

In this embodiment, at least one scale line 23 is provided on the outer surface of the distal end of the air return pipeline 22, and the scale line 23 is a printed scale line or an engraved scale line. sensor.

In this embodiment, the expandable member 1 is provided with an expanded state and a contracted state, and the refrigerated medium (such as liquid nitrogen) enters the expandable member 1 through the air outlet 211 provided on the side wall of the inlet pipeline 21, so that the expandable member 1 becomes In the expanded state, the thermal insulation area 11 isolates the cold energy transfer of the freezing medium, and the ablation area 12 realizes cold energy transfer for cryoablation to achieve the purpose of treatment, and the freezing medium flows back through the air return line 22 .

Example 2

This embodiment is another preferred structural form of the cryoablation catheter. As shown in Figure 4, the structure of the cryoablation catheter described in this embodiment is basically the same as that of Embodiment 1, the only difference is that the heat insulation area 11 and the ablation area 12 have the same wall thickness, but the materials used in both Differently, the heat insulation area 11 is made of a material with a low thermal conductivity, specifically polyvinyl chloride; the ablation area 12 is made of a material with a high thermal conductivity, specifically polyamide.

Example 3

This embodiment is another preferred structural form of the cryoablation catheter. As shown in Figure 5, the structure of the cryoablation catheter described in this embodiment is basically the same as that of Embodiment 1, the only difference is that the heat insulation area 11 and the ablation area 12 have the same wall thickness, and the materials used in both It can be the same or different. The outer diameter of the ablation area 12 is greater than the outer diameter of the heat insulation area 11. Specifically, the outer wall of the ablation area 12 is a hemispherical or approximately hemispherical structure that protrudes outward. The outer diameter of the ablation area 12 is 1.05 to 1.5 times the outer diameter of the hot zone 11 . In this embodiment, when the expandable member 1 is in the expanded state, since the outer diameter of the ablation region 12 is relatively large, it will preferentially contact the site to be damaged, thereby achieving the purpose of local cryoablation.

Example 4

This embodiment is another preferred structural form of the cryoablation catheter. As shown in Figure 6, the structure of the cryoablation catheter described in this embodiment is basically the same as that of Embodiment 1, the only difference is that the outer diameters of the thermal insulation area 11 and the ablation area 12 are the same, and have the same or different walls thickness, the materials used by the two can be the same or different, when the wall thickness is different, the wall thickness of the heat insulation area 11 is greater than the wall thickness of the ablation area 12; when the materials are different, the heat insulation area 11 uses a material with a low thermal conductivity, Specifically, it is made of polyvinyl chloride, and the material of the heat insulation area is a multi-layer structure with a heat insulation material with pores; the ablation area 12 is made of a material with high thermal conductivity, specifically polyamide material; in addition, the number of ablation areas 12 is Two of them are in the form of 360° annular bands. Two symmetrically distributed air outlets 211 are provided on the side wall of the intake pipeline 21 corresponding to each ablation area 12 . The ablation area 12 and the heat insulation area 11 are spaced apart.

Example 5

This embodiment is another preferred structural form of the cryoablation catheter. As shown in Figure 7, the structure of the cryoablation catheter described in this embodiment is basically the same as that of Embodiment 1, the only difference is that: the heat insulation area 11 and the ablation area 12 have the same or different wall thicknesses, and the two adopt The materials can be the same or different. When the wall thicknesses are different, the wall thickness of the heat insulation area 11 is greater than that of the ablation area 12; when the materials are different, the heat insulation area 11 uses a material with a low thermal conductivity, specifically polyvinyl chloride. The ablation area 12 is made of a material with a high thermal conductivity, specifically polyamide material; in addition, the number of ablation areas 12 is 2, which are all in the form of a 180° ring structure, and each ablation area 12 is located on a different plane along the axial direction. It divides the expandable member into ablation regions 12 and heat insulation regions 11 that are staggered in the radial direction. Specifically, the expandable member 1 is divided into two symmetrical parts up and down as shown in FIG. 7 , the first side of the upper part is the ablation area 12, the second side of the upper part is the thermal insulation area 11, the first side of the lower part corresponding to the first side of the upper part is the thermal insulation area 11, and the second side of the lower part corresponding to the second side of the upper part The side is the ablation area 12, and the side wall of the air intake pipeline 21 corresponding to each ablation area 12 is provided with one or more air outlets.

Example 6

This embodiment is another preferred structural form of the cryoablation catheter. As shown in Figure 8, the structure of the cryoablation catheter described in this embodiment is basically the same as that of Embodiment 1, the only difference is that: the heat insulation area 11 and the ablation area 12 have the same or different wall thicknesses, and the two adopt The materials can be the same or different. When the wall thicknesses are different, the wall thickness of the heat insulation area 11 is greater than that of the ablation area 12; when the materials are different, the heat insulation area 11 uses a material with a low thermal conductivity, specifically polyvinyl chloride. ; The ablation area 12 is made of a material with high thermal conductivity, specifically polyamide material; and the number of ablation areas 12 is 2, which are all in the form of 180° annular bands, and the outer diameter of the ablation area 12 is larger than that of the heat insulation area 11 The outer diameter, specifically the outer wall of the ablation area 12 is a hemispherical or approximately hemispherical structure protruding outward, and each ablation area 12 is located in a different plane along the axial direction, which separates the expandable member into staggered ablation areas 12 and The thermal insulation area 11, specifically, the expandable member is divided into two symmetrical parts as shown in FIG. From top to bottom, it is divided into heat insulation area 11, ablation area 12 and heat insulation area 11, but the left and right ablation areas 12 are not on the same plane, and the side walls of the intake pipeline 21 corresponding to each ablation area 12 are opened with 1 an outlet.

Example 7

This embodiment is a method of using the cryoablation catheter described in any one of Embodiments 1 to 6 to injure the pulmonary vagus nerve, which includes the following steps: clarifying the target position of the isolated lung tissue; under endoscopic monitoring, Introducing a cryoablation catheter, the cryoablation catheter includes an expandable member and a pipeline connected to the proximal end of the expandable member, the expandable member is provided with an expanded state and a contracted state, pushing the cryoablation catheter to the target tissue, and making the cryoablation catheter The distal end of the endoscope extends farther than the distal part of the endoscope; confirm that the damaged part matches the target tissue; input the freezing medium to make the expandable member into an expanded state, and start the cryoablation procedure. The cryoablation procedure includes cryoablation process and recovery During the warm process, cryoablation is performed on the designated parts to achieve the purpose of damaging the vagus nerve in the lungs.

The above-mentioned target tissue can be the left main bronchus, the right main bronchus, or both the left and right main bronchus; the above-mentioned target tissue can be cryoablated all at once, or can be cryoablated several times; , can be combined with lung navigation technology; wherein, the step of introducing the cryoablation catheter can be introduced through the channel of the endoscope itself, or the cryoablation catheter can be introduced side by side with the endoscope; wherein, The step of confirming the coincidence of the surgical site with the target tissue can be observed directly, or can be combined with various detection methods, such as X-ray machines; among them, the cryoablation procedure includes the cryoablation process and the rewarming process, and cryoablation is performed on the designated site to achieve damage The purpose of the lung vagus nerve is to repeat the cryoablation injury to the same target tissue to achieve a better effect of cryoablation injury.

It can be known from the above examples that the present invention uses an endoscope according to the lung airway structure, and has the advantages of less trauma, shorter operation time, and high safety; the application of cryoablation in the airway is safer than thermal ablation, and has the advantages of The damage to the airway wall structure is small, and it is not easy to cause complications such as airway stenosis; the use of endoscope and cryoablation method can effectively control the complications of the ablation method while damaging the nerve; the vagus nerve of the lung is located outside the airway wall, When the lung vagus nerve is injured by intervening cryoablation in the airway, in order to achieve the effect of nerve injury, the present invention adopts an ablation catheter with an expandable member at the end, which has a larger capsule (cavity) in the expanded state for Sufficient cold and heat exchange, so that cryo-injury penetrates the entire airway wall, ablation and thermal insulation zones are placed on the expandable member to minimize unnecessary tissue damage.

The specific embodiments of the present invention have been described in detail above, but they are only examples, and the present invention is not limited to the specific embodiments described above. For those skilled in the art, any equivalent modifications and substitutions to the present invention are also within the scope of the present invention. Therefore, equivalent changes and modifications made without departing from the spirit and scope of the present invention shall fall within the scope of the present invention.

Claims (13)

1. a kind of cryoablation conduit, including expandable members (1) and the pipeline (2) being connect with the expandable members (1), Be characterized in that, area of insulation (11) and ablation areas (12) be set on the expandable members (1), the pipeline (2) include into Air pipe (21) and return line (22), the air inlet pipeline (21), return line (22) with the expandable members (1) Inner cavity chamber's connection.

2. a kind of cryoablation conduit according to claim 1, which is characterized in that prolong the end (21) of the air inlet pipeline It protrudes into the expandable members (1), the distal end fixed seal connection of distal end and the expandable members (1) is expanded described It opens and opens up at least one gas outlet (211) on component (1) internal air inlet pipeline (21).

3. a kind of cryoablation conduit according to claim 2, which is characterized in that the return line (22) is sheathed on institute The outside or the return line (22) for stating air inlet pipeline (21) are arranged side by side with the air inlet pipeline (21), the return line (22) distal end is fixedly connected with the proximal end of the expandable members (1), and is connected with the inner cavity chamber of the expandable members (1) It is logical.

4. a kind of cryoablation conduit according to claim 1, which is characterized in that along circle on the expandable members (1) Temperature sensor and/or pressure sensor is arranged in circumferential direction.

5. a kind of cryoablation conduit according to claim 1, which is characterized in that the appearance of the distal end of the pipeline (2) At least 1 graduation mark (23) is arranged in face.

6. a kind of cryoablation conduit according to any one of claims 1 to 5, which is characterized in that the area of insulation (11) wall thickness is greater than the wall thickness of the ablation areas (12).

7. a kind of cryoablation conduit according to any one of claims 1 to 5, which is characterized in that the area of insulation (11) identical with the wall thickness of ablation areas, the area of insulation (11) material low using the coefficient of heat conduction, the ablation areas (12) material high using conduction-convection problem.

8. a kind of cryoablation conduit according to any one of claims 1 to 5, which is characterized in that the area of insulation It (11) the use of kinds of interlayer is the multilayered structure with the heat-insulated material of stomata.

9. a kind of cryoablation conduit according to any one of claims 1 to 5, which is characterized in that the ablation areas (12) outer diameter is greater than the outer diameter of the area of insulation (11).

10. a kind of cryoablation conduit according to any one of claims 1 to 5, which is characterized in that the ablation areas It (12) is one or more, the ablation areas (12) is in axial direction located at Different Plane, and expandable members (1) is separated For the ablation areas (12) and area of insulation (11) being interspersed in the radial direction.

11. a kind of freeze melting device containing cryoablation conduit according to any one of claims 1 to 5.

12. a kind of if cryoablation conduit according to any one of claims 1 to 5 is in building lung's vagus nerve injury model In application.

13. a kind of side for carrying out lung's vagus nerve injury using cryoablation conduit according to any one of claims 1 to 5 Method, which comprises the following steps: clear target tissue site；The expandable members (1) of introducing freeze melting device simultaneously will It pushes to target tissue；The ablation areas (12) and target tissue for confirming expandable members (1) are coincide；Refrigerant is inputted, institute is made Expandable members (1) are stated into expanded condition,；Cryoablation program is opened, cryoablation is carried out to appointed part, to complete damage lung Portion's vagus nerve.